POSTER SESSION II Thursday, May 28 16:00-18:00

POSTER SESSION II Thursday, May 28 16:00-18:00

POSTER SESSION II
Thursday, May 28 16:00-18:00
Imaging: Radiometals
099
Potential labeling strategies with NCA 197(m)Hg
Martin Walther (Helmholtz-Zentrum Dresden-Rossendorf, Germany)
101
p-NO2-Bn-bisDFO: A new high denticity chelator for 89Zr radiochemistry
Eric W. Price (Memorial Sloan Kettering Cancer Center, United States)
102
Nitroimidazole-containing acyclic chelates as potential PET imaging agents of hypoxia with 68Ga
Caterina F. Ramogida (University of British Columbia, Canada)
103
Simple, effective, and stable radioarsenic labeling of thiol-modified mesoporous silica nanoparticles
Paul Ellison (University of Wisconsin, United States)
104
First 111In-labeled activity-based probe for SPECT imaging of uPA activity: in vivo study in human cancer
xenografts
David Thomae (University of Antwerp, Belgium)
105
An attractive method for radiolabeling antibodies with Tc-99m
Gerd Wunderlich (TU Dresden, Germany)
106
Synthesis and evaluation of the first non-peptidic [99mTc]labeled ligand for the molecular imaging of
inflammatory processes using S100A9 as novel target
Andreas Faust (University Münster, Germany)
107
64
108
Radiolabeled PTK7 targeting aptamer: challenges and approaches
Victoria Calzada (Centro de Investigaciones Nucleares, Uruguay)
110
Exploration of 89Zr-Nano-Hydroxyapatite as a PET Tracer
Stacy Queern (Washington University of St. Louis, United States)
111
The application of metal free click-chemistry to imaging cancer targeting phage
María F. Garcia (Universidad de la República, Uruguay)
112
Labelling and preclinical evaluation of NOTA cyclo-RGD dimers labelled with Ga-68 for imaging of the
integrin receptors
Dana Niculae (National Institute for Physics and Nuclear Engineering, Romania)
113
Evaluation of In-House Manufactured 99mTc-ECDG in Baboons: Normal Biodistribution
Jan Rijn Zeevaart (Radiochemistry, Necsa, South Africa)
120
68
114
Ultrasmall radioiodinated αMSH-C dots for melanoma imaging and therapy
Xiuli Zhang (University of Missouri, United States)
115
A DOTA based bisphosphonate containing an albumin binding moiety for delayed body clearance in bone
targeting radiotherapy
Nina Pfannkuchen (Johannes Gutenberg-University, Germany)
116
Dual Indium-111 and Fluorescent Labeling of iRGD-Targeted Undecylenic-acid –modified Thermally
Hydrocarbonized Porous Silicon (UnTHCPSi) Particles for Drug Delivery System Evaluation In Vivo
Mirkka Sarparanta (University of Helsinki, Finland)
Cu-labelling and preclinical evaluation of NODAGA-cetuximab-F(ab’)2
Cheng-Bin Yim (University of Turku and Åbo Akademi University, Finland)
Ga-NOTA-UBI: A novel PET imaging probe detecting infection
Jan Rijn Zeevaart (Radiochemistry, Necsa, South Africa)
117
Synthesis and Evaluation of [2+1] Re(I)/99mTc(I) Complexes as Isostructural Luminescent Turn-on and
Nuclear Imaging Probe
Abdolreza Yazdani (McMaster University, Canada)
118
Radiolabeling DNA aptamers with 68Ga for molecular cancer imaging
Marlies Gijs (University of Liège, Belgium)
119
Design of a Trivalent 99mTc-Probe for High Avidity Receptor Targeting and Enhanced Target Uptake
Yuki Mizuno (Chiba University, Japan)
121
The revival of 111In leukocyte labeling?
Svend B. Jensen (Aalborg Universitets hospital, Denmark)
122
64
123
Development and evaluation of a new bifunctional chelator (DOTAPyr) for multimodal molecular imaging
via PET, SPECT, NIR and MRI
Sebastian Görres (Hannover Medical School, Germany)
124
Optimization of labeling PSMAHBED with 68Ga and its quality control systems
Elisabeth Eppard (University Hospital Bonn, Germany)
125
Authentically radiolabelled Mn(II) complexes as bimodal PET/MR tracers
Johannes Ermert (Institut für Neurowissenschaften und Medizin, Germany)
Cu-labeled human serum albumin for tumor imaging
Hyunjung Kim (Samsung Medical Center, Korea)
PET: F-18
187
A fully automated, one-step and one Curie level radiosynthesis of nca [18F]UCB-H, a radiotracer for the PET
imaging of SV2A
Corentin Warnier (University of Liege, Belgium)
188
Preclinical characterization of [18F]THK-5117 enantiomers as a PET probe for tau pathology in Alzheimer’s
disease
Tetsuro Tago (Tohoku University, Japan)
189
Radiosynthesis and in vitro evaluation of N-aryl-18F-fluorodeoxyglycoylamines as prodrugs for imaging the
acidic interstitial microenvironment
Robert R. Flavell (University of California, United States)
190
Iodonium Ylide Mediated Radiofluorination: Expanded Substrate Scope and Validation of a
Radiopharmaceutical for Human Use
Steven H. Liang (MGH/Harvard, United States)
191
Structure activity relationships of 18F-labeled 7α-alkyl-estradiol derivatives
Jun Toyohara (Tokyo Metropolitan Institute of Gerontology, Japan)
192
Radiosyntheis of [18F]RAGER, the First Small-Molecule PET Radioligand for In Vivo RAGE Quantification
Peter J. Scott (University of Michigan, United States)
238
Mechanistic Studies on Forming [18F]Trifluoromethyl Groups from Gem-difluoroenol Ethers
Peter J. Scott (University of Michigan, United States)
193
Evaluating the Metabolism Profile of the Novel AT1R Radioligand, [18F]FPyKYNE-Losartan, in Rat Kidney
and Pig Plasma
Jean DaSilva (Université de Montréal, Montréal, Canada)
194
The development of new amino acid derivatives using click reaction and simple SPE purification method
Cheol-min Yook (Asan medical center, Korea)
195
[18F]FLT prodrug strategy for in vivo detection of H 2O2 using PET
Valerie N. Carroll (University of California San Francisco, United States)
196
Phase-transfer catalytic,nucleophilic, asymmetric synthesis of 6-[18F]-L-DOPA with simplified cleavage of the
protective group
Roger Schibli (Villigen-PSI, Switzerland)
197
Synthesis of [18F]IDO5L: a novel potential PET probe for imaging of IDO-1 expression
Xuan Huang (H. Lee Moffitt Cancer Center and Research Institute, United States)
198
Synthesis of a New Thiol Reactive Bifunctional Agent [ 18F]FPyAM using Microfluidic System
David W. Blevins (The University of Tennessee Medical Center, United States)
214
Synthesis of N-[4-(2'-[18F]fluoroethyloxybenzoyl)]pyrrolidin-2-one, a Potential New Brain Imaging Agent
David W. Blevins (University of Tennessee Medical Center, United States)
199
Improved production of [18F]PF-05270430 for clinical imaging of PDE2A in brain
Thomas Morley (New Haven, United States)
200
Automated Production of 18F-labeled Acyl Fluorides as 18F-fluorination Synthons
Timothy R. DeGrado (Jiang Mayo Clinic, United States)
201
Synthesis of PET tracers via SN2 radiofluorination under "minimalist" conditions
Bernd Neumaier (University Clinic Cologne, Germany)
202
Preparation of [18F]fluorodopamine ([18F]FDA), [18F]-m-tyrosine ([18F]FMT) and 6-[18F]fluoro-(3,4dihydroxyphenyl)alanine ([18F]FDOPA) via nickel-mediated fluorination with [18F]fluoride
Bernd Neumaier (University Clinic Cologne, Germany)
203
Development of peptidic fluorine-18 labeled PET tracers for in vivo determination of tissue transglutaminase
activity
Berend van der Wildt (VU University Medical Center, Netherlands)
204
Targeting lysyl oxidase for molecular imaging in breast cancer
Reik Löser (Helmholtz-Zentrum Dresden-Rossendorf, Germany)
205
Synthesis, 18F-labeling and radiopharmacological characterization of a claudin-targeting peptide
Reik Löser (Helmholtz-Zentrum Dresden-Rossendorf, Germany)
206
New strategy of a two-step radiosynthesis of [18F]fluoropyridine-based maleimide-containing prosthetic
groups for labelling of peptides and proteins
Melanie Cavani (Institut für Neurowissenschaften und Medizin, Germany)
207
A new method for the two-step synthesis of n.c.a. 6-[18F]fluorotryptophan
Dominique C. Schäfer (Institut für Neurowissenschaften und Medizin, Germany)
208
Radiosynthesis and preclinical evaluation of [18F]6-fluoro-marsanidine – potential α2A-adrenoceptor tracer.
Anna Krzyczmonik (University of Turku, Finland)
209
A fluorine-18 labeled prodrug targeting excitatory amino acid transporters: development of nucleophilic and
electrophilic radiosynthetic approaches
Henry F. Van Brocklin (University of California San Francisco, United States)
210
One-Step Regioselective Diaryl Iodonium Salt Preparation From a Koser Reagent and an Electron Rich
Arene
Sung Hoon Kim (University of Illinois, United States)
211
[18F]Tau911, a candidate for PET imaging of the THK site in neurofibrillary tangles
Lisheng Cai (National Institute of Mental Health, United States)
212
18
F-PARPi-FL as novel potential dual modality PET/Optical probe for PARP1 imaging
Giuseppe Carlucci (Memorial Sloan Kettering Cancer Center, United States)
215
Conversion of Pyridine N-Oxides to Trialkylammonium Precursors of 2-Fluoropyridines and Its Application
to the Radiosynthesis of [18F]AV-1451
Hui Xiong (Avid Radiopharmaceuticals, United States)
216
Improved synthesis and purification of meta-[18F]fluorobenzylguanidine (mFBG) for clinical use
Amy L. Vavere (St. Jude Children's Research Hospital, United States)
218
The development and imaging with human osteocalcin in female mice; [F-18] FB-Osteocalcin (FBO)
Patrick Carberry (Columbia University Medical Center, United States)
219
Radiosynthesis of fluorinated a7 ligands and their evaluation by biodistribution and µPET studies
Johnny Vercouillie (CERRP, France)
220
One-pot radiosynthesis of [18F]FEDAC as a clinically applicable PET ligand for imaging TSPO.
Kazunori Kawamura (National Institute of Radiological Sciences, Japan)
221
Novel 18F-labelled triazine derivatives for PET imaging of phosphodiesterase 2A
Susann Schröder (Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany)
222
Synthesis and evaluation of a novel 18F-labelled radiotracer for cyclooxygenase-2 (COX-2) imaging
Ole Tietz (University of Alberta, Canada)
223
Synthesis and [18F]labeling of a fluoropyridinyl analogue of the TSPO ligand SSR180575, modified at the
N,N-dimethylacetamide position
Fanny Cacheux (Service Hospitalier Frédéric Joliot, France)
224
Strategies for Green Fluorine-18 Radiochemistry
Megan N. Stewart (The University of Michigan, United States)
225
In Vivo Albumin Labeling with 18F-AlF-NEB for Lymph Node Imaging
Xiaoyuan Chen (National Institutes of Health, United States)
230
Automation of [18F]VAT Using the Eckert and Ziegler Modular-Lab, GE TRACERlab FX-N Module
Xuyi Yue (Washington University, United States)
231
{Al18F}2+ approach: Studies of new chelators for radiolabelling biomolecules at mild conditions
Joan Lecina (KU Leuven, Belgium)
232
Optimized Microwave Assisted 18F-DOPA Synthesis Using a Diaryliodonium Salt Precursor
Alejandro Amor-Coarasa (Weill Cornell Medical College, United States)
233
Photoactivated F-18 Fluorination on a Novel BODIPY Derivative
Alan B. Packard (Boston Children's Hospital/Harvard Medical School, United States)
234
Development of a Continuous Flow Microwave Reactor and Its Application to the Radiochemistry
Hiroyuki Kimura (Kyoto University, Japan)
PET: C-11 and Other
301
[11C]MADAM used as a model for understanding the metabolism of diphenyl sulfide positron emission
tomography radioligands.
Fabienne Gourand (GIP Cyceron, France)
302
Microdose study of 11C radiolabeled Donecopride, a multi-target-directed ligand for Alzheimer’s disease
treatment.
Fabienne Gourand (GIP Cyceron, France)
303
Single valve module for production and efficient transfer of [ 11C]carbon monoxide to a disposable reaction
vial
Jonas Eriksson (Uppsala University Hospital, Sweden)
304
[11C] Carbonylation via Conversion of [11C]CO2 → [11C]CO Mediated by [11C]Silane Derivatives
Carlotta Taddei (King's College London, United Kingdom)
305
Synthesis and biological evaluation of 2-amino-2-[11C]methyl-butanoic acid as a potential PET probe for
tumor imaging
Chie Suzuki (National Institute of Radiological Sciences, Japan)
306
Radiosynthesis of [11C]S44121, a first-in-class drug targeting the ryanodine receptor calcium release channel
Frédéric Dollé1 (Service hospitalier Frédéric Joliot, France)
289
Carbon-11-labelling of two novel indole-2-carboxamides targeting the TSPO
Frédéric Dollé (Service Hospitalier Frédéric Joliot, France)
307
Radiosynthesis and pharmacokinetic comparison of 1-N-[11C]methyl]-L- and -D-tryptophan
Ming-Rong Zhang (National Institute of Radiological Sciences, Japan)
309
Development of electronegative LDL mimotope peptide based tracers for atherosclerosis PET imaging
Soraya M. Kazuma (Washington University in St. Louis, United States)
310
Cu-64-ATSM PET scanning predicts degree and location of tumor hypoxia in dogs for hypoxia-directed
therapy
Jeffrey N. Bryan (University of Missouri, United States)
311
Syntheses and Evaluation of Carbon-11- and Fluorine-18-Radiolabeled pan-Tropomyosin Receptor Kinases
(Trk) Inhibitors for PET imaging.
Frank Wuest (University of Alberta, Canada)
312
Synthesis of a candidate brain-penetrant COX-2 PET radioligand as a potential probe for neuroinflammation
Michelle Cortes (NIH, United States)
313
A Microscale Radiosynthesis of [C-11]-Rosuvastatin
Jeanne M. Link (Oregon Health & Science University, United States)
Estimation of the unbound brain to plasma ratio for CNS drug candidates – comparing results obtained with
PET microdosing and microdialysis in non-human primates
Peter Johnström (Karolinska Institutet, Sweden)
314
315
Preclinical evaluation of the NET-PET-tracer [11C]Me@APPI
Christina Rami-Mark (Medical University of Vienna, Austria)
316
On the search for novel PET tracers for the Norepinephrine Transporter
Christina Rami-Mark (Medical University of Vienna, Austria)
317
Efficient [13N]nitrate reduction catalyzed by Aspergillus niger nitrate reductase immobilized on positively
charged carrier
Eunice Sofia da Silva Fernandes (San Sebastian / Donostia, Spain)
318
Transition Metal Mediated Kumada Cross Coupling of [11C]CH3I and Aryl Grignard
Johan H. Dam (Odense University Hospital, Denmark)
320
Synthesis of Symmetrical Ureas via the Direct Incorporation of [11C]CO2
Abdul Karim Haji Dheere (King's College London, United Kingdom)
291
Improved Radiosynthesis of the P-glycoprotein Tracer (R)-[11C]Verapamil Using A New HPLC Purification
Method
Ya-Yao Huang (National Taiwan University Hospital, Taiwan)
340
Radionuclide imaging of metastatic melanoma using 68Ga-glyco-click-conjugates.
Izabela Tworowska (RadioMedix Inc., United States)
Radiopharmacy
355
New quantification method of radiochemical purity using Cerenkov radiation
Yeong Su Ha (National University School of Medicine, Korea)
356
Two Novel Nanosized Radiolabeled Analogues of Somatostatin for Neuroendocrine Tumor Imaging
Blanca E. Ocampo-García (Instituto Nacional de Investigaciones Nucleares, Mexico)
358
Good manufacturing practice compliant production of a 68Ga-labelled Affibody agent for breast cancer
imaging: first-in-human
Irina Velikyan (Uppsala University Hospital, Sweden)
259
Melanoma targeting with [99mTcN(PNP3)]-labeled α-MSH peptide analogs: Preliminary studies
Feng Gao (Institute of Radiopharmaceutical Cancer Research, Germany)
360
Evaluation of various bifunctional chelators for the synthesis of radiometal-labeled CNS tracers
Anett Schulz (Johannes-Gutenberg Universität, Germany)
362
Preparation of [F-18]FLT using an ABT compact cyclotron and continuous flow microfluidics
Lee Collier (R&D, Advion Inc., United States)
364
Facile synthesis of 6-[18F]FDOPA using electrophilic substitution reaction
Yong-Hyun Cho (Seoul National University Hospital, Korea)
365
Preparation and Characterization of Dendrimer-Encapsulated Ytterbium Nanoparticles to produce a New
Nano- Radio Pharmaceutical
Navideh Aghaei Amirkhizi (Islamic Azad University, Iran)
366
Preparation of 99mTc-BDTC complexes and evaluation as tumor marker
Fabio L. Navarro Marques (University of São Paulo, Brazil)
367
Studying the Biological Potential of [99mTc(CO)3]-Dextran-Cysteine-Cysteine-Mannose (DCCM) as a feasible
Molecular Radiopharmaceutical for Sentinel Node Detection
Irfan U. Khan (Institute of Nuclear Medicine and Oncology (INMOL), Pakistan)
368
Synthesis and preclinical evaluation of the 99mTc-Bombesin-Folate heterobivalent peptide for simultaneous
imaging of folate and gastrin-releasing peptide receptors
Liliana Aranda Lara (Instituto Nacional de Investigaciones Nucleares, Mexico)
372
11
373
Using anti CEA antibody [123I]HB8747 for luminal targeting of colorectal cancer
Joost Verbeek (Philips Research Europe, Netherlands)
413
Diphenoxyalkane Derivatives with More Flexible Scaffold as Probes for β-Amyloid Plaques
H. Jia (Beijing Normal University, China)
C-labeling and evaluation of E55888, a 5-HT7R agonistic PET tracer
Matthias Herth (University of Copenhagen, Denmark)
Targetry, Production and Separations
396
68
Ge quantification in eluate and after 68Ga-DOTA-peptide labelling for clinical application
Erik de Blois (Erasmus MC, Netherlands)
397
Production of Platinum Radioisotopes at Brookhaven Linac Isotope Producer (BLIP)
Suzanne V. Smith (Brookhaven National Laboratory, United States)
398
Automated and monitored liquid target transfer system
Milan Vuckovic (BC Cancer Agency, Canada)
399
Development of a separation for the purification of Actinium-225 from bulk Thorium
Jonathan Fitzsimmons (Brookhaven National Lab, United States)
400
Solid phase synthesis of 62Cu-bis(thiosemicarbazonato) via transmetalation based on a new 62Cu/62Zn
generator
Zilin Yu (King's College London, United Kingdom)
392
A simplified conventional manual C18 Light Sep-Pak system for purification and reformulation of carbon-11
PET tracers
Qi-Huang Zheng (Indiana University, United States)
384
Multiple Bacteriophage Selection Strategies for Improved Affinity of a Peptide Targeting ERBB2
Susan L. Deutscher (Harry S. Truman Veterans Memorial Hospital, United States)