Brian P. Hobbs - Quantitative Sciences

June 17, 2015
CURRICULUM VITAE
Brian P. Hobbs
CONTACT INFORMATION
Assistant Professor
Department of Biostatistics
The University of Texas MD Anderson Cancer Center
PO Box 301402, Unit 1411
1400 Pressler Street
Houston, TX 77230-1402
phone: (713) 794-4633; fax: (713) 563-4243
e-mail: bphobbs@mdanderson.org
EDUCATION
2004 BA, Anthropology
minor, Computer Science, with high distinction University of Iowa
2007 MS, Biostatistics
University of Minnesota
2010 PhD, Biostatistics
University of Minnesota
PROFESSIONAL EXPERIENCE
2011 –
Assistant Professor, Department of Biostatistics, The University of Texas MD Anderson Cancer Center
2010 – 2011
Postdoctoral Fellow, Department of Biostatistics, The University of Texas MD Anderson Cancer Center
EXTERNAL ADVISORY BOARDS
2013
Grant Proposal Reviewer, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
2015
Grant Proposal Reviewer, National Cancer Institute, NIH
INSTITUTIONAL COMMITTEE & REVIEW ACTIVITIES
MD Anderson Cancer Center
2013 –
Multidisciplinary Research Advisory Committee
2014 –
Data and Safety Monitoring Board
PEER REVIEWED PUBLICATIONS (*=corresponding author, **=my trainee)
1. Hobbs BP, Carlin BP (2008). Practical Bayesian design and analysis for drug and device clinical trials, J.
Biopharmaceutical Statistics, 18: 54–80.
2. Hobbs BP*, Carlin BP, Mandrekar S, Sargent DJ (2011). Hierarchical commensurate and power prior models for
adaptive incorporation of historical information in clinical trials, Biometrics, 67: 1047–1056.
3. Hobbs BP*, Sargent DJ, Carlin BP (2012). Commensurate priors for incorporating historical information in clinical
trials using general and generalized linear models, Bayesian Analysis, 7: 639–674.
4. Schellingerhout D, LeRoux LG, Hobbs BP, Bredow S (2012). Impairment of retrograde neuronal transport in
oxaliplatin-induced neuropathy demonstrated by molecular imaging, PLoS ONE, 7(9):e45776, 9/2012. e-Pub
9/20/2012. PMID: 23029238.
5. Hobbs BP*, Carlin BP, Sargent DJ (2013). Adaptive adjustment of the randomization ratio using historical control
data, Clinical Trials, 10: 430-440.
6. Nute JL, Rong J, Stevens DM, Darensbourg BJ, Cheng J, Wei W, Hobbs BP, Cody DD (2013). Evaluation of over 100
scanner-years of computed tomography daily quality control data, Medical Physics, 40(5):051908-1 to 051908-11.
Curriculum Vitae – Brian P. Hobbs, Ph.D.
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7. Ng CS, Hobbs BP, Chandler AG, Anderson EF, Herron DH, Charnsangavej C, Yao J (2013). Metastases to the liver from
neuroendocrine tumors: Effect of duration of scan acquisition on CT perfusion values, Radiology, 269(3): 758-767.
8. Rauch GM, Kuerer HM, Scoggins ME, Fox PS, Benveniste AP, Park YM, Lari SA, Hobbs BP, Krishnamurthy S, Yang WT
(2013). Clinicopathologic, mammographic, and sonographic features in 1187 patients with pure ductal carcinoma in
situ of the breast by estrogen receptor status, Breast Cancer Research and Treatment, 139(3): 639-647.
9. Viele K, Berry S, Neuenschwander B, Amzal B, Chen F, Enas N, Hobbs BP, Ibrahim JG, Kinnersley N, Lindborg S,
Micallef S, Roychoudhury S, Thompson L (2014). Use of historical control data for assessing treatment effects in
clinical trials, Pharmaceutical Statistics, 13: 41-54.
10. Murray TA, Hobbs BP, Lystig TC, Carlin BP (2014). Semiparametric Bayesian commensurate survival model for postmarket medical device surveillance with non-exchangeable historical data, Biometrics, 70: 185-91.
11. Ng CS, Chandler AG, Yao J, Herron DH, Anderson EF, Charnsangavej C, Hobbs BP (2014). Effect of pre-enhancement
set-point on CT perfusion values in normal liver and metastases to the liver from neuroendocrine tumors, Journal of
Computer Assisted Tomography, 38(4): 526-34.
12. Castillo S, Castillo R, Balter P, Pan T, Ibbott G, Hobbs B, Yuan Y, Guerrero T (2014). Assessment of a quantitative
metric for 4D CT artifact evaluation by observer consensus, Journal of Applied Clinical Medical Physics, 15(3): 190201.
13. Amini B, Madewell J, Chuang H, Haygood T, Hobbs B, Fox P, Bassett R, Costelloe C (2014). Differentiation of benign
fluid collections from soft-tissue sarcomas on FDG-PET/CT, Journal of Cancer, 5(5): 328-335.
14. Castillo R, Pham N, Ansari S, Meshkov D, Castillo SJ, Li M, Olanrewaju AM, Hobbs BP, Castillo E, Guerrero T (2014).
Pre-Radiotherapy FDG PET predicts radiation pneumonitis in lung cancer, Radiation Oncology, 9 (74).
15. Caudle A, Yang W, Mittendorf E, Black D, Hwang R, Hobbs B, Hunt K, Krishnamurthy S, Kuerer H (2015). Selective
surgical localization of axillary lymph nodes containing metastases in patients with breast cancer: a prospective
feasibility trial. JAMA Surgery, 150(2):137-43.
16. Castillo R, Pham N, Castillo E, Gonzalez SA, Ansari S, Hobbs B, Palacio D, Skinner H, Guerrero T (2015). PreRadiotherapy FDG PET identifies esophageal cancer patients at high-risk for radiation pneumonitis, Radiology, in
press, doi:10.1148/radiol.14140457.
17. Tan CH, Hobbs BP, Wei W, Kundra V (2015). Dynamic contrast enhanced MRI for the detection of prostate cancer:
meta-analysis, American Journal of Roentgenology, Apr;204(4):W439-48.
18. Castillo SJ, Castillo R, Castillo E, Balter P, Pan T, Ibbott G, Hobbs B, Guerrero T (2015). Evaluation of 4D CT acquisition
methods designed to reduce artifacts, Journal of Applied Clinical Medical Physics, 16(2).
19. Ng CS, Hobbs BP, Wei W, Anderson E, Herron DH, Yao JC, Chandler AG. Effect of sampling frequency on perfusion
values in CT perfusion of liver tumors and normal liver, Journal of Computer Assisted Tomography, in press.
20. Ma J**, Hobbs BP, Stingo FC. Statistical methods for establishing personalized treatment rules in oncology, BioMed
Research International, Article ID 670691, in press (invited submission).
21. Wang Y**, Hobbs BP*, Hu J, Ng C, Do KA. Predictive classification of correlated targets with application to detection
of metastatic cancer using functional CT imaging, Biometrics, in press.
Curriculum Vitae – Brian P. Hobbs, Ph.D.
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22. Hobbs BP*, Ng CS. Inferring stable acquisition durations for applications of perfusion imaging in oncology, Cancer
Informatics, in press (invited submission).
23. Murray TA, Hobbs BP, Carlin BP. Combining nonexchangeable functional or survival data sources in oncology using
generalized mixture commensurate priors, Annals of Applied Statistics, in press.
24. Murray TA, Hobbs BP, Sargent DJ, Carlin BP. Flexible Bayesian survival modeling with semiparametric timedependent and shape-restricted covariate effects, Bayesian Analysis, in press.
25. Wang Y**, Hobbs BP*, Ng C. CT perfusion characteristics identify metastatic sites in liver, BioMed Research
International, in press (invited submission).
26. Ravoori M, Nishimura M, Singh S, Lu C, Han L, Hobbs BP, Pradeep S, Choi HJ, Bankson J, Sood A, Kundra V. Tumor T1
relaxation time for assessing response to bevacizumab anti-angiogenic therapy in a mouse ovarian cancer model,
PLoS ONE, in press.
27. Hobbs BP*. On nonparametric hazard estimation, Journal of Biometrics & Biostatistics, in press.
28. Raghav KPS, Mahajan S , Yao JC, Hobbs BP, Berry DA, Pentz RD, Tam A, Hong WK, Ellis LM, Abbruzzese J, Overman
MJ. From protocols to publications: a study in selective reporting of outcomes in randomized trials in oncology,
Journal of Clinical Oncology, in press.
29. Hobbs BP*, Thall PF, Lin SH. Bayesian group sequential clinical trial design using total toxicity burden and
progression-free survival, Journal of the Royal Statistical Society: Series C, in press.
BOOK CHAPTERS
1. Hobbs BP, Lee JJ (2012). Adaptive Trial Design, In Handbook of Statistics in Clinical Oncology, 3rd ed., Ed(s) Crowley J,
Hoering A, Ankerst DP, Chapman and Hall/CRC Press: Boca Raton, FL.
SUBMITTED FOR PUBLICATION
1. Kamali F, Wang W-L, Guadagnolo A, Fox PS, Lewis VO, Lazar AJ, Conley AP, Toliyat M, Ladha HS, Hobbs BP, Amini B.
MRI can be used as a prognostic indicator in patients with desmoid fibromatosis.
2. Hobbs BP*, Chen N, Lee JJ. Controlled multi-arm platform design using predictive probability.
3. Yao D, Hazle JD, Mohamed ASR, Frank SJ, Hobbs BP, Colen RR, Gunn GG, Wang J, Garden AS, Lai SY, Rosenthal DI,
Fuller CD. Intravoxel incoherent motion imaging kinetics during chemoradiotherapy for human-papilloma virus
associated squamous cell carcinomas of the oropharynx: preliminary results from a prospective pilot study.
4. Koopmeiners JS, Hobbs BP. Detecting and accounting for violations of the constancy assumption in non-inferiority
clinical trials.
5. Ma J**, Stingo FC, Hobbs BP*. Bayesian predictive modeling for genomic based personalized treatment selection.
6. Rauch GM, Hobbs BP, Kuerer HM, Scoggins ME, Benveniste AP, Park YM, Lari SA, Fox PS, Smith BD, Adrada BE,
Krishnamurthy S, Yang WT. Microcalcifications in 1,657 patients with pure ductal carcinoma in situ of the breast:
mammographic findings with clinical, histopathologic, biologic correlation and analysis of local recurrence.
7. Rohren EM, Etchebehere EC, Araujo JC, Hobbs BP, Swanston NM, Everding M, Moody T, Macapinlac HA.
Determination of skeletal tumor burden on 18F-Fluoride-PET/CT.
Curriculum Vitae – Brian P. Hobbs, Ph.D.
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8. Azadeh S, Hobbs BP, Ma L, Nielsen D, Moeller FG, Baladandayuthapani V. Integrative Bayesian Analysis of
Neuroimaging-Genetic Data with Application to Cocaine Dependence.
GRANT SUPPORT
1. Co-Investigator, 15%, Spatially Accurate Deformable Image Registration for Thoracic CT Applications, 1 DP2
OD007044, NIH/NIGMS, PI - Thomas Guerrero, 9/30/2010 – 6/30/2015, $7,500,000 ($1,500,000/year).
2. Collaborator, 1.8%, Personalizing Nanoparticle Therapy, 5 R01 CA159042 02, NIH/NCI, PI – Vikas Kundra, 3/1/2011 –
2/29/2016, $1,147,665 ($228,187/year).
3. Co-Investigator (subcontract), 6%, Multimode Laser Optoacoustic Tomography System for Breast Cancer Care, 1 R01
CA167446-01, NIH/NCI, Prime - TomoWaves Laboratory, PI - Alexander Oraevsky, 5/1/2012 – 3/31/2017, $566,415
($70,738/year).
4. Principal Investigator (subcontract), 20%, Statistical Methods and Software for More Efficient, Ethical, and
Affordable Clinical Trials, 1 R01 CA157458 01 A1, NIH/NCI, Prime - Univ. of Minnesota, PI - Bradley Carlin, 6/1/2012 –
5/31/2015, $130,557 ($43,519/year).
5. Statistician, 10%, Cancer Center Support Grant - Biostatistics Shared Resource (PPSR-21), 5 P30 CA016672 36,
NIH/NCI, PI - Ronald Depinho, 6/1/2012 – 5/31/2013, $13,006,702 ($611,160/year).
6. Co-Investigator, 5%, A New Radiopharmaceutical for the Treatment of Metastatic Bone Cancer, 2 R44 CA15060102A1, PI – Jim Simon, Iso Therapeutics Group, LLC, 7/1/2013−6/30/2015, $58,520 ($28,018/year).
7. Co-Investigator, 10%, Statistical Methods for Complex Cancer Trials, 5 R01 CA083932, NIH/NCI, PI – Peter Thall,
1/1/2014 – 4/30/2018, $775,000 ($155,000/year).
8. Co-Investigator, 2%, Tumor mutation status will predict metabolic response to metformin in NSCLC, 1 R21
CA182964-01A1, NIH/NCI, PI – Thomas Guerrero; Heath Skinner, 7/1/2014 – 6/30/2016.
ABSTRACTS (2012 - 2014 only)
1. MacLellan C, Hobbs BP, Chasen B, Murthy R, Mahvash A, Kappadath SC (2012). Absorbed dose differences in 90Y
microsphere therapy between pre-treatment 99m Tc-MAA and post- treatment 90Y scans, Journal of Nuclear
Medicine, 53 (Supplement 1):1494.
2. MacLellan C, Hobbs BP, Chasen B, Murthy R, Mahvash A, Kappadath SC (2012). Absorbed dose differences in 90Y
microsphere therapy between pre-treatment 99m Tc-MAA and post- treatment 90Y scans, Australian and New
Zealand Society of Nuclear Medicine.
3. Rauch GM, Kuerer HM, Scoggins ME, Benveniste AP, Fox PS, Yang WT, Park YM, Lari SA, Hobbs BP, Krishnamurthy S
(2012). Biologic subtype and imaging correlates of 1,187 patients with pure ductal carcinoma in situ of the breast,
Radiological Society of North America, #SSM02-04.
4. Martaindale S, Hobbs BP, Yang WT, Albarez R, Krishnamurthy S, Le-Petross HC (2012). Assessment of residual
disease using mammography (MG), sonography (US), and magnetic resonance imaging (MRI) in patients (pts) with
inflammatory breast cancer (IBC) who received neoadjuvant chemotherapy (NAC), Radiological Society of North
America, #LL-BRS-SU5A.
Curriculum Vitae – Brian P. Hobbs, Ph.D.
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5. Meshkov D, Castillo R, Castillo E, Li M, Pham N, Pollard J, Fuentes D, Olanrewaju A, Hobbs B, Guerrero T (2013). Preradiotherapy FDG PET predicts radiation pneumonitis in non-small cell lung cancer patients, Society of Nuclear
Medicine and Molecular Imaging
6. Meshkov D, Castillo R, Castillo E, Fuentes D, Pham N, Li M, Olanrewaju A, Pollard J, Hobbs B, Guerrero T (2013).
Clinical symptoms of radiation pneumonitis correlate with pulmonary metabolic radiation dose-response in lung
cancer patients, NCI Joint Workshop: Technology for Innovation in Radiation Oncology
7. Bathala T, Rauch GM, Bass M, Borst D, Hobbs B, Bedi DG (2013). Diagnostic performance of conventional
ultrasonography combined with US Strain Elastography for differentiation between benign and malignant
subcutaneous soft tissue mass lesions, Radiological Society of North America, #13020161.
8. Rauch GM, Hobbs B, Kuerer HM, Scoggins ME, Lari S, Yang WT, Benveniste AP, Park YM, Adrada B, Fox P,
Krishnamurthy S (2013). Microcalcifications in 1,658 patients with pure ductal carcinoma in situ of the breast:
imaging findings with clinical, histopathologic and biologic correlation, Radiological Society of North America,
#13020375.
9. Caudle AS, Yang W, Krishnamurthy S, Hobbs BP, Mittendorf EA, Black D, Hwang R, Hunt KK, Kuerer HM (2014).
Targeted axillary dissection for node positive breast cancer: a feasibility trial for selective resection of axillary lymph
node metastases, Society of Surgical Oncologists.
10. Pham N, Castillo R, Fox P, Castillo E, Ansari S, Castillo E, Hobbs B, Guerrero T (2014). Higher doses to smaller volumes
explain higher proton therapy radiation pneumonitis rates found, American Society for Radiation Oncology.
11. Castillo S, Castillo R, Castillo R, Pan T, Ibbott G, Balter P, Hobbs B, Dai J, Guerrero T (2014). Improved Cine FourDimensional Computed Tomography (4D CT) Acquisition and Processing Method, American Association of Physicists
in Medicine, #TH-E-17A-7.
12. Kamali F, Wang W, Guadagnolo A, Fox PS, Lewis VO, Lazar AJ, Conley AP, Toliyat M, Ladha HS, Hobbs BP, Amini B
(2014). MRI can be used to risk stratify patients with extra-abdominal desmoid fibromatosis, Musculoskeletal Tumor
Society, 10/11/2014
13. Caudle AS, Yang W, Mittendorf EA, Black DM, Gilcrease M, Bedrosian I, Hobbs BP, Candelaria RP, Babiera GV, Dogan
BE, Lim MJ, Santiago L, Hunt KK, Krishnamurthy S, Kuerer HM (2015). Targeted axillary dissection improves axillary
evaluation following neoadjuvant chemotherapy in node positive patients, Society of Surgical Oncologists, abstract
id: 2093551.
COURSE INSTRUCTION
The University of Texas Graduate School of Biomedical Sciences & Rice University
2014 Topics in Clinical Trials
Guest Lecture
University of Minnesota
2007 Introduction to Bayesian Analysis
2008 Biostatistics I
2009 Introduction to Bayesian Analysis
Rice University
2012 Topics in Clinical Trials
DOCTORAL STUDENT THESIS ADVISORY
Rice University Department of Statistics
1. Katherine Shoemaker (in progress)
Curriculum Vitae – Brian P. Hobbs, Ph.D.
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The University of Texas School of Public Health Department of Biostatistics
1. Caimiao Wei, “Bayesian modeling of combined endpoints for sequentially adaptive design and confirmatory trial
planning,” May 2015.
2. Shabnam Azadeh, (in progress) co-advised with Dr. Veera Baladandayuthapani
3. Meilin Huang (in progress)
DOCTORAL STUDENT ADVISORY COMMITTEE
The University of Texas Graduate School of Biomedical Sciences
1. Sarah Castillo, Medical Physics, 2013 – 2014
2. Hannah Lee, Medical Physics, 2013 –
POSTDOCTORAL FELLOWS
The University of Texas MD Anderson Cancer Center
1. Yuan Wang, 2013 – (joint with Kim-Anh Do)
2. Junsheng Ma, 2013 – (joint with Francesco Stingo)
SHORT COURSES
1. One-day short course, “Recent Advances in Bayesian Adaptive Clinical Trial Design”, Joint Statistical Meetings,
Montreal, QC, CA. Taught jointly with P. Thall, August 4, 2013.
2. One-day short course, “Recent Advances in Bayesian Adaptive Clinical Trial Design”, International Chinese Statistical
Association & Korean International Statistical Society Joint Applied Statistics Symposium, Portland, OR. Taught
jointly with P. Thall, June 15, 2014.
SESSION CHAIR & ORGANIZATION
2015 Chair of invited session, “Novel Designs and Applications of Adaptive Randomization in Medical Research,”
International Chinese Statistical Association Joint Applied Statistics Symposium
2015 Organized contributed session, “Response-Adaptive Randomization: Recent Developments and Controversies,”
National Joint Statistical Meetings/American Statistical Association
2015 Chair of invited session, “Bayes and Nonparametric Bayes Methods in Medical Studies,” National Joint Statistical
Meetings/American Statistical Association
OTHER PRESENTATIONS
Invited Department Seminars
2010 Department of Health Studies, University of Chicago
2010 Department of Preventive Medicine, Northwestern University
2010 Federal Drug Administration, Center for Devices and Radiological Health
2010 Department of Biostatistics, The University of Texas MD Anderson Cancer Center
2010 Department of Biostatistics, University of Iowa
2010 Eli Lilly Research Laboratories
2011 Division of Biostatistics and Human Genetics Center, The University of Texas Health Science Center at Houston
2011 Department of Biostatistics, The University of Texas MD Anderson Cancer Center
2011 Division of Biostatistics, University of Minnesota
2012 Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
2012 Department of Statistics, Rice University
2013 Department of Epidemiology, Biostatistics and Occupational Health, McGill University
2013 Division of Biostatistics and Human Genetics Center, The University of Texas Health Science Center at Houston
2013 Center for Clinical and Translational Sciences, The University of Texas Health Science Center at Houston
2015 Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
Conference Presentations
2009 Invited paper, Bayesian Biostatistics Conference, The University of Texas MD Anderson Cancer Center
Curriculum Vitae – Brian P. Hobbs, Ph.D.
2010
2011
2011
2011
2011
2011
2012
2012
2013
2013
2013
2013
2014
2015
2015
2015
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Poster, Bayesian Biostatistics Conference, The University of Texas MD Anderson Cancer Center
Contributed paper, Eastern North American Regional International Biometric Society Meeting
Poster, Joint International Society for Bayesian Analysis/Institute of Mathematical Statistics Meeting
Poster, Bayesian Biostatistics Conference, The University of Texas MD Anderson Cancer Center
Contributed paper, National Joint Statistical Meetings/American Statistical Association
Invited paper, International Conference on Health Policy Statistics
Contributed paper, Eastern North American Regional International Biometric Society Meeting
Contributed paper, National Joint Statistical Meetings/American Statistical Association
Invited paper, Eastern North American Regional International Biometric Society Meeting
Invited paper, The Conference of Texas Statisticians
Contributed paper, National Society for Clinical Trials Meeting
Contributed paper, National Joint Statistical Meetings/American Statistical Association
Invited paper, National Society for Clinical Trials Meeting
Invited paper, National Joint Statistical Meetings/American Statistical Association
Invited paper, International Chinese Statistical Association Applied Statistics Symposium
Invited paper, Workshop on Statistical Imaging/American Statistical Association
AWARDS & HONORS
2004 Phi Beta Kappa Academic Honor Society
2007 Jim Boen Award for Outstanding Student Achievement, Division of Biostatistics, University of Minnesota
2008 Outstanding Teaching Assistant Award, Division of Biostatistics, University of Minnesota
2008 Student Travel Award, Bayesian Biostatistics Conference, The University of Texas MD Anderson Cancer Center
2010 Student Travel Award, Bayesian Biostatistics Conference, The University of Texas MD Anderson Cancer Center
2010 Jacob E. Bearman Student Achievement Award, Division of Biostatistics, University of Minnesota
2010 John Van Ryzin Award, Eastern North American Region of International Biometric Society
2011 Poster Award, International Society for Bayesian Analysis/Institute of Mathematical Statistics Meeting
OTHER APPOINTMENTS/RESPONSIBILITIES
- Statistical Mentor, NIDA Pre-doctoral and Post-doctoral fellowships in Statistical Genetics of Addiction, Houston, TX,
8/2013-present
PROFESSIONAL ACTIVITIES
Memberships
2006 – Eastern North American Region/International Biometric Society (ENAR/IBS)
2009 – American Statistical Association (ASA)
2011 – Society for Clinical Trials (SCT)
2012 – International Society for Bayesian Analysis (ISBA)
2012 – American Association for Cancer Research (AACR)
2012 – Drug Information Association, Bayesian Scientific Working Group (DIA)
Manuscript referee
2007 Journal of Biopharmaceutical Statistics
2010 Biometrics
2012 Clinical Cancer Research
2013 Statistics in Medicine
2013 Clinical Trials
2013 Biometrics
2013 Bayesian Analysis
2014 Biometrics
2014 Statistics in Medicine
2014 Biometrics
Curriculum Vitae – Brian P. Hobbs, Ph.D.
2014
2014
2014
2014
2015
2015
Biostatistics
Bayesian Analysis
Annals of Applied Statistics
Annals of Applied Statistics
Statistics in Medicine
Statistics in Medicine
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