Foredrags- & Posterkonkurrence Abstracts 2015-6

Transcription

Foredrags- & Posterkonkurrence
Abstracts
2015-6
Art: F = Foredrag, P = Poster
Art
Hjemsted
1
2
3
F
F
F
AAU
AU
DTU
Forfatter – kun
indsenderen er nævnt
Mads Jochumsen
Line Nørgaard Christensen
Shadi Chreiteh
4
F
AU
Philip Weng
5
F
AAU
Mathias Brønd Sørensen
6
F
Sundhedsinformation
Sjælland
m.fl.
Erik S. Poulsen
7
F
AU
Morten Jensen
8
F
AU
Ida Lindhardt Jensen
9
F
AU
Tommy Bechsgaard
10
F
AU
Søren Nielsen Skov
11
F
AU
Michael Væggemose
Magnetic resonance diffusion tensor imaging for
evaluation of Diabetic Polyneuropathy
12
P
AU
Troels Lading
In Vitro charachterization and comparison of the David
and the Yacoub aortic root repair techniques with and
without a supporting annular ring
13
P
DTU
Ali Hohebbi
14
15
P
P
DTU
AU
16
P
DTU
Sissel Bisgaard
Anders Esager
Caspar Aleksander Bang
Jespersen
17
P
SDU
Kathrine Holz
18
P
DTU
Alexander Neergaard Olesen
19
P
AU
Thomas Lindskow
Nr.
13.09.2015/POR
Titel
Decoding movement intensions from single-trial EEG
Individualised 3D printed brachytherapy applications
Vital signs monitorering at the sternum
Optimation og in vitro detection of mechanical heart
valve cavitation
Diagnosticering af knoglemetastaser hos patienter med
prostacancer
Considerations when starting a Medtech Company
Development of a new heart valve porsthesis concept for
pediatric cardiac surgery
In Vitro investigation of pulmonary valve prosthesis
constructed in CorMatrix in treatment of Tetralogy of
Fallot
Biomechanical description of aortic root repair
procedures,preliminary
Biomedical Features of a rigid remodeling Versus a fully
flexible Mitral Annuloplasty Ring
A brain computer interface for robust wheelchair control
application
Supportive algorithm for detection of REM
Cell sorter for isolation of insulin producing cells
Appnea: Novel Smartphone Based Application for Sleep
Apnea Detection
Evaluating the use of EEG for monitoring Patiens in the
neurointensive care unit
Nonparametric Bayesian Analysis of the Mouse Brain
Connectome
Assesment and comparision of stress distribution in the
aortic root:after aortic root repair using Davids or
Yacoubs technique
SKABELON
Foredragskonkurrence
Medicotekniske landsmøde
Forfatter/Kontakt person:
Adresse:
Tlf. nr.:
E-mail:
Mads Jochumsen
Fredrik Bajers Vej 7 D2-103, 9220 Aalborg Ø
40544421
mj@hst.aau.dk
Slet eksempel og skriv abstrakt i testruden: Alle forfattere skal anføres; foredragsholderen skal understreges, max 200 ord:
MADS JOCHUMSEN, ASTRID C. NØRGAARD, MADS N. STAUSHOLM,
REGITZE K. SKALS, SIMON C. DAHL & ERNEST N. KAMAVUAKO
Department of Health Science and Technology, Aalborg University
DECODING MOVEMENT INTENTIONS FROM SINGLE-TRIAL EEG
Intentions to move can be seen in the EEG ~2 s prior movements; this may be
exploited for reestablishing a disrupted motor control loop through braincomputer interfacing.
In this work, movement intentions associated with three grasp types (pinch,
palmar and lateral) were decoded from single-trial EEG. 14 healthy subjects
performed the three grasps 100 times while EEG from 25 channels was recorded over the contralateral sensorimotor cortex. The continuous EEG was divided
into epochs from the movement onset and 2 s prior this point and epochs containing background EEG (Fig. 1). To estimate movement detection, background
EEG vs. movement intention classification was performed using linear discriminant analysis. The movement intentions were classified as well. Temporal
(mean amplitudes) and spectral (power spectral densities) features were extracted from each channel. Dimensionality reduction was performed using Fisher’s
discriminant projection.
On average 89±5% (temporal features) of the movement intentions was correctly detected, and 56±11% (spectral features) was correctly classified according
to the grasp type. Combining temporal and spectral features did not improve the
performance. In conclusion, single-trial movement intentions can be decoded;
this may be used for brain-computer interface applications for motor recovery
or substitution.
Fig. 1: Averaged brain potentials associated with different grasps.
Abstrakt sendes til: porasmus@post9.tele.dk
Forfatter/Kontakt person: Line Nørgaard Christensen
Adresse: Jerichausgade 15 St.Tv.
Tlf. nr.: 42423634
E-mail: Line.n.Christensen@gamil.com
SOFIE GUNHØJ MIKKELSEN, NITA VOLDER HANSEN &
LINE NØRGAARD CHRISTENSEN
Aarhus University School Of Engineering
INDIVIDUALISED 3D PRINTED BRACHYTHERAPY APPLICATORS
Worldwide, cervical cancer is the fourth most frequent cancer in women with
an estimated 530.000 new cases in 2012. Brachytherapy is a treatment offered
by Aarhus University Hospital, combining external radiation with internal localized radiation therapy. Fifty percent of all patients receive an intracavitary
treatment with an applicator, forty percent receives a combined
intracavitary/interstitial treatment with fixed needles in a tandem ring. The
remaining ten percent of patients require additional free needles to be inserted.
These are necessary when tumors are not positioned parallel to the applicator.
The aim of this project is to enable construction of individualized brachytherapy
applicators to fixate the free needles.
A software program will be created to transfer geometrical information about
the location of the tumor and applicator into CAD software, allowing individualized applicators to be designed and 3D printed with angled holes for the free
needles. This optimization will make it possible to fix the free needles and optimize the final position relative to the target, yielding an optimal dose distribution for the individualized treatment.
In addition to facilitating the technical transfer of information, the workflow
and quality assurance of the treatment will be examined and optimized.
Fig. 1.Cervical tumor with needles
Fig. 2: Old version of racyteraphy applicator in cervix
Adresse:
Tlf. nr.:
E-mail:
Shadi S. Chreiteh
DTU Nanotech, Ørsteds Plads,
28158184
shach@nanotech.dtu.dk
Bygning 345B, 2800 Kgs. Lyngby
SHADI S. CHREITEH1, BO BELHAGE2, KARSTEN HOPPE3 & ERIK V.
THOMSEN1
1
Department of Micro- and Nanotechnology, DTU
Bispebjerg Hospital
3
DELTA microelectronics
2
VITAL SIGNS MONITORING AT THE STERNUM
For critically ill patients, it is highly important to obtain reliable measures of
vital sign parameters, e.g. heart rate, respiration rate, and the oxygen saturation
of the blood. The respiratory rate is assessed by manual count of the chest
movements and pulse oximetry probes have previously been limited to the fingertip. These methods are documented to be time consuming or inaccurate
when monitoring patients with low blood flow or decreased perfusion at the
extremities (e.g. patients with COPD, diabetes, or heart failure).
In this project, we have developed an optical sensor that can monitor the respiratory rate and the oxygen saturation of the blood at the sternum, cf. Fig.1. On a
healthy group of subjects the respiratory rates were derived with a root mean
squared error (RMSE) of 1.2 breaths /min during spontaneous respiration. As
for the oxygen saturation it was derived with RMSE of 2 % during a hypoxia
study. Recently, a clinical experiment conducted on 30 respiratory affected
patients at Bispebjerg Hospital has showed that we were able to estimate the
respiratory rate with a RMSE of 1.5 breaths/min compared to traditional capnography. The oxygen saturation was estimated with a RMSE of 2 %.
These results indicates that, it is possible to design a unique device that can
provide vital information about the respiration rate, the heart rate, and the oxygen saturation while reducing the limitations of traditional pulse oximetry
probes. In the future, this new sensor is therefore expected to be able to provide
continuous, reliable, and wireless monitoring of important vital signs in critically ill patients.
Fig.1. Prototype of sternal reflectance photoplethysmographic sensor. The sensor is placed at the chest bone (sternum) using state of the art patch technology.
Abstrakt sendes til: por@dmts.dk
Adresse:
Tlf. nr.:
E-mail:
Philip Weng
Silkeborgvej 76 3. tv
40434069
philipbsweng@gmail.com
PHILIP WENG & PETER JOHANSEN
Department of Engineering, Faculty of Science and Technology, Aarhus University, Denmark
OPTIMIZATION OF IN VITRO DETECTION OF MECHANICAL HEART VALVE CAVITATION
An in vitro setup, based on a mechanical heart valve single shot model was developed to investigate valve-closing sounds under non-cavitating to high cavitating conditions, in order to refine
existing cavitation detection schemes. This was done, by placing the single shot model, including the pump, into a pressurized chamber. By also including the pump into the pressure chamber, cavitation was suppressed with unaltered valve closing velocity. As the pressure was increased, cavitation was gradually suppressed until completely suppressed. The occurrence of
cavitation was verified through high-speed images of the valve closure.
Dataset acquired at non-cavitating and highly cavitating conditions were initially used to identify and derive algorithms for detection and quantification of cavitation.
Fig. 1 shows the result of the most successful method developed based on analysis of large
negative pressure transients, which was identified within the valve closing sound signature
during the cavitation conditions. At gauge pressures up to 0.8 bar, cavitation demonstrated a
very stochastic behavior, which is illustrated by the large variance and box size. This was also
expected, as the occurrence of cavitation is thought to be stochastic. At pressures above 0.8 bar,
the measurements shows a linear descending pattern, representing the suppression of cavitation.
Fig. 1: Boxplot of all datasets at each surrounding pressure. The dataset at fully suppressed
cavitation is used as a reference to determine the grade of cavitation.
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Mathias Brønd Sørensen
Borgergade 21, 3 tv. 9000 Aalborg
26399128
mbsa12@student.aau.dk
Aida Hejlskov Poulsen, Kasper Kunz Leerskov, Mathias Brønd Sørensen &
Rosa Hansen - Sundhedsteknologi-studerende på Aalborg Universitet
Vejledere: Ole Kæseler Andersen, AAU & Thomas Bohsen Schmidt, AAUH
DIAGNOSTICERING AF KNOGLEMETASTASER HOS PATIENTER MED
PROSTATACANCER
Prostatacancer er den hyppigste cancersygdom hos mænd med circa 4.000 tilfælde og op mod 1.200 dødsfald årligt. De fleste dødsfald er forårsaget af
spredning, der hos prostatacancer patienter oftest forekommer i knoglerne.
Scanning for knoglemetastaser foregår i dag med SPECT/CT-teknologi, ved en
knogleskintigrafi, men nye tiltag giver anledning til revurdering af den gængse
scanningsmetode.
Med udgangspunkt i den tilgængelige videnskabelige litteratur og med MTVtilgang sammenlignes knogleskintigrafi og 18F-NaF PET/CT inden for fire
væsentlige perspektiver i sygehusregi; teknologi, organisation, økonomi og
patient.
Under litteraturstudiet er det fundet, at 18F-NaF PET/CT er mere sensitiv end
knogleskintigrafi både med og uden SPECT. Blandt andet på grund af en bedre
spatiel opløsning, hvilket betyder, at knoglemetastaser kan detekteres tidligere
med PET/CT-teknologien. Den tidligere detektering er forbundet med større
livskvalitet og færre senkomplikationer for patienten.
På Aalborg Universitetshospitalet udføres først en planar knogleskintigrafi, der
ved tvivl-tilfælde suppleres med en SPECT/CT af et eller flere områder af patienten. Ved at supplere med en SPECT/CT tager undersøgelsen længere tid,
også længere tid end at udføre en 18F-NaF PET/CT-scanning, hvilket bevirker,
at 18F-NaF PET/CT kan være mere scanningstids-effektiv såfremt de knogleskintigrafier, der suppleres med SPECT/CT udgør mere end 36 % af samtlige
udførte knogleskintigrafier, da er en 18F-NaF PET/CT-scanning mere tidseffektiv.
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Erik S. Poulsen, MD, MSc
Hovmestervej 3 st. th., DK-2400 København NV
25825835
eriksp@gmail.com
ERIK S. POULSEN, HEINE SKOV.
In collaboration with Sundhedsinnovation Sjælland, Næstved Hospital,
Bispebjerg Hospital, and Cortrium ApS.
CONSIDERATIONS WHEN STARTING A MEDTECH COMPANY
The aim of this talk is to discuss the Danish healthcare system’s ability to adopt
novel technologies and mobile health innovations (mHealth) in general. Common key considerations and challenges when introducing novel medical technologies into medical markets and will be discussed. These range from business
aspects, hard-, and software design, through legislative requirements. Further,
Danish medical device startup company, Cortrium will also be briefly introduced. Cortrium has developed a simple and inexpensive vital sign monitoring
system. During the talk, this system will be live-demonstrated. Finally, preliminary results from clinical pilot studies will be presented and discussed.
Fig. 1:The complete back-bone of Cortrium’s medical device vital sign
monitoring system displayed. This includes a hardware sensor, iOS application,
cloud service, and a frontend web administrations module.
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Morten Bjørn Jensen
Elmegade 10, 8200 Aarhus N
51927057
mortenbjoernjensen@gmail.com
MORTEN H. SMERUP, PETER JOHANSEN & MORTEN B. JENSEN.
Department of Engineering, Aarhus University
DEVELOPMENT OF A NEW HEART VALVE PROSTHESIS CONCEPT FOR
PEDIATRIC CARDIAC SURGERY
In infant heart valve surgery only few therapeutic options exist
and there exist no off-the-shelf valve substitute. Therefore, it
would be a great advantage if a heart valve substitute could be
individually constructed during surgery that exactly suits the need
of the specific patients.
A newly developed technique may be able to present such a novel
therapeutic solution in pediatric cardiac surgery. By means of preoperative echocardiographic measurements and intraoperative
assessment of key anatomical dimensions, the surgeon will be able
to create an artificial heart valve made of fixated autologous pericardium during surgery.
Five upscaled heart valves with varying leaflet length were tested
in a pulsatile left heart in vitro model with constant pressure and
heart rate and varying cardiac output. Geometric and effective
orifice area, mean and peak pressure gradient, regurgitant fraction,
backflow, opening and closing velocity and coaptation length were
assessed through pressure and flow recordings, high speed imaging and ultrasonography.
The infant valve showed good hemodynamic performance with
pressure gradients comparable to gradients found for other bioprosthesis. The initial in vitro testing proofed the concept of the
infant valve and showed that the hemodynamic properties varied
with the geometry and have led to further development of the design concepts.
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Ida Lindhardt Jensen
de Mezas vej 15, 2. Tv.
28772329
idalindhardt@gmail.com
Ida Lindhardt1, Ditte Bruus1, Jonas Rasmussen2, Marcell Tjørnild2, Tommy
Bechsgaard1,2, Vibeke E. Hjortdahl2, Peter Johansen1,2
1
Cardiovascular Experimental Laboratory, Aarhus University, Department of Engineering
2
Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital.
In vitro investigation of pulmonary valve prosthesis constructed in CorMatrix in treatment of Tetralogy of Fallot
Tetralogy of Fallot is a congenital heart disease with pulmonary stenosis being
one of the major malformations. The surgical treatment of this condition is
effective, but often requires multiple surgeries with pulmonary valve replacement, in order to avoid heart failure and arrhythmia in adulthood.
The aim of this present study is to evaluate in a functional perspective the geometry of a pulmonary valve prosthesis designed and manufactured in the
CorMatrix material. The pulmonary valve prostheses are installed in a pulsatile
in vitro flow loop and the hemodynamic characteristics of the valves are investigated based on a number of measurements conducted under the physiological
conditions present in the right side of the heart in a human adult. The in vitro
model is equipped with transit time flowmeters, microtip pressure catheters, and
the valve operation is captured through high-speed imaging. Hence, the valve is
evaluated in means of the pressure drop during systole, the valve opening area
over time, the valve leaflet coaptation height and the valve leakage (during
diastole).
Figure 1 shows five selected high-speed images illustrating the movements of
the leaflets from valve closure to valve opening during a single heart cycle.
Figure 1. High-speed images of CorMatrix valve.
The overall conclusion of the in vitro part is that a feasible platform has been
developed that can test and evaluate various designs with different geometrical
details. Hereby, a unique setup has been made available for experimental validation of various design optimization approaches. The following step is for the
valves to be tested in vivo through animal experimental studies.
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Tommy Bechsgaard
Finlandsgade 22, 8200 Aarhus N
22558010
tombech84@gmail.com
Biomechanical description of aortic root repair procedures, preliminary
results
T Bechsgaard1,2, T Lindskow2, TL Sørensen2, JL Hønge2, H Nygaard2, SL Nielsen2, P Johansen1,2
1
Department of Engineering, Faculty of Science and Technology, Aarhus University, Denmark
2
Department of Cardiothoracic & Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark
Objectives: Patients with aortic regurgitation secondary to ascending aortic dilation or
aneurism can be treated with valve sparing techniques such as the David reimplantation
or the Yacoub remodeling technique. In order to quantify the physiological impact of
these two repair procedures, new force transducers have been developed and tested.
Materials and Methods: New force transducers were developed, manufactured and
calibrated to assess the force distribution of the aortic root repair procedures. The transducers were developed using rapid prototyping in plastic material. Miniature strain
gauges were meticulously mounted on the transducer. Both transducers were calibrated
under static conditions. Fresh porcine aortic roots were collected from a local slaughterhouse and installed in an in vitro model along with the force transducers. Forces from the
annulus and at the commissural points of the aortic root were collected, along with blood
pressure and flow, 2D echocardiography and high- speed imaging.
Results and Discussion:
The static calibration of the force transducers revealed a linear r2 coefficient > 0.99. The
forces reported were collected at a systolic pressure of 110 mmHg with a flow of 5l/min.
In the systolic phase, the preliminary forces for the native, David repair and Yacoub
repair were 1.1N, 0.6N, 0.7N respectively.
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Søren Nielsen Skov
Grønnegade 55, 2. Lej 13 – 8000 Aarhus C
40186364
soeren.skov@clin.au.dk
Biomechanical Features of a Rigid Remodeling Versus a Fully Flexible Mitral Annuloplasty Ring
Søren Nielsen Skov1,2,3, Diana Mathilde Røpcke1,2, Christine Ilkjær1,2, Jonas Rasmussen1,2 , Marcell Juan
Tjørnild1,2, Hans Nygaard1,2, Morten Olgaard Jensen3,4 and Sten Lyager Nielsen1,2
1
Dept. of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark
Dept. of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
3
Dept. of Engineering, Faculty of Science and Technology, Aarhus University, Aarhus, Denmark
4
Dept. of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, USA
2
Different mitral valve pathologies may require different remodelling properties of annuloplasty rings. The aim
of this study was to conduct a comprehensive biomechanical assessment of the remodelling effects of a rigid
versus a fully flexible mitral annuloplasty ring in-vivo.
The characterization of mitral annuloplasty rings was performed in-vivo in an 80 kg porcine model. 21 animals
were divided into three groups: A no ring group, a rigid ring group and a flexible ring group. Mitral annular
deformational forces were measured with a novel annular force transducer optimized for simultaneous force
measurements in- and out of the mitral annulus plane. Geometry was measured with a sonomicrometry ultrasound technique (11 crystals).
Annular motion was significantly decreased with a rigid ring compared to the no ring and flexible ring group.
Accordingly, restrictive annular motion resulted in significantly lower deformational forces measured in the
rigid ring.
The study is the first to demonstrate significant differences of cyclic deformation and deformational forces of
rigid remodelling versus fully flexible mitral annuloplasty rings. Remodelling may act intentionally for mitral
valve repair, however reduction of deformational reflects forces accumulation in the ring construction and suture attachment that potentially may lead to ring dehiscence and repair failure.
No Ring (n=7)
Parameter
Rigid Ring (n=7)
Flexible Ring (n=7)
Max
Min
Difference
Max
Min
Difference
Max
Min
Difference
Mitral annular area [mm2]
760 ± 114
613 ± 114
147 ± 64
685 ± 101
645 ± 92
40 ± 22*
756 ± 150
658 ± 164
98 ± 63#
Mitral annular circum. [mm]
112 ± 14
100 ± 16
11 ± 5
107 ± 7
104 ± 7
3 ± 1*
107 ± 10
99 ± 10
7 ± 3#
Septal-lateral distance [mm]
33 ± 2
29 ± 3
4±2
29 ± 5
28 ± 6
2 ± 2*
33 ± 4
29 ± 4
4 ± 2#
Commissural distance [mm]
30 ± 4
27 ± 3
3±2
32 ± 5
30 ± 5
2±1
35 ± 4
30 ± 4
4 ± 1#
Table 1: Difference (Max-Min) between *: Ring vs. no ring group; #Rigid vs. flexible ring - (p<0.05)
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Michael Væggemose
Aarhus Universitetshospital
20 68 50 41
mivegg@clin.au.dk
M. Væggemose, M. Pham, S. Ringgaard, H. Tankisi, N. Ejskjaer, P. L. Poulsen,
H. Andersen
Magnetic resonance diffusion tensor imaging for evaluation of
Diabetic Polyneuropathy
Aim
To evaluate the use of magnetic resonance (MR) diffusion tensor imaging (DTI)
to demonstrate nerve lesions in patients with type 1 diabetes.
Methods
Ten type 1 diabetic patients with polyneuropathy (+PNP), 10 type 1 diabetic
patients without polyneuropathy (-PNP) and 10 healthy controls (HC) were
included. Diffusion tensor images were acquired to evaluate the extent of focal
lesions in the sciatic and tibial nerve using a 3 Tesla scanner. DTI fractional
anisotropy (FA) and apparent diffusion coefficients (ADC) were calculated. The
MR scans consisted of 16 axial slices of the sciatic nerve and the tibial nerve.
The presence of PNP was determined based on nerve conduction studies, vibratory perception thresholds and clinical neurological examination.
Results
FA values of the sciatic nerve were significantly lower in diabetic patients with
PNP compared to controls and diabetic patients without PNP, (+PNP: 0.39
(0.25-0.43), -PNP: 0.47 (0.41-0.52), HC: 0.48 (0.41-0.59)) (median, range) (p <
0.01). Furthermore, there was a difference in the ADC between the groups,
(+PNP: 1611 (1382-2220), -PNP: 1489 (1389-1599), HC: 1420 (1250-1608)) (p
< 0.01). Results from the tibial nerve where equivalent.
Conclusion
Diffusion tensor imaging of the sciatic and tibial nerve showed lower FA values
and higher ADC values in diabetic patients with PNP as compared to healthy
controls and non-neuropathic patients. Lower FA values and higher ADC may
reflect less constriction of flow along the nerve indicating demyelination and
axonal loss PNP.
Fig. 1- Fibertract of sciatic nerve
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Troels Lading
Fuglesangs Alle 28, st. 108. 8210 Aarhus V
51966830
troels.lading@gmail.com
In vitro charachterization and comparison of the David and the
Yacoub aortic root repair techniques with and without a supporting annular ring
Lading TS1, Røpcke DM1, Lindskov T, Bechsgaard T2, Johansen P2,
Nygaard H2, Hasenkam JM1, Nielsen SL1
1
Department of Cardiothoracic & Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark
2
Department of Engineering, Faculty of Science and Technology,
Aarhus University, Denmark
Corresponding author: troels.lading @gmail.com
Objectives: The aim of this study is to compare the aortic remodeling techniques, with and without a supporting ring, in vitro, comparing biomechanics of the native aortic root and valve to the root and valve after a Yacoub
and a David repair technique. In total five groups will be analyzed and
compared; Native aortic root as reference, native aortic roots with a supporting annular ring, Davids reimplantation technique, Yacoubs remodeling
technique and Yacoubs remodeling technique with a supporting annular
ring. The measurements used for comparison are leaflet dynamics, annular
and aortic force distribution and hemodynamics.
Materials and Methods: Twenty-five porcine aortic roots (100 kg) will be
prepared and randomized to either no aortic remodeling (n=5), no aortic
remodeling with addiotional supporting annular ring (n=5), or to a David
(n=5), or to a Yacoub (n=5) repair technique or to a Yacoub repair technique with addiotional supporting annular ring (n=5), which will be performed ex vivo before mounting the aortic root in the in vitro model.Two
circular force transducers will be placed in the aortic annulus and at the
sinotubular junction, respectively, These transducers will measure annular
contraction and dilation of the root. The annulus transducer consists of six
strain gauges allowing individual force measuremets at each strain gauge
point of the ring. The forces at each commisure of the aortic valce will be
measured by attachment of three strain gauges mounted on the transducer
ring at the sinotubular junction. Microtip pressure catheters will be used for
pressure measurements, and a highspeed camera will be used for digital
imaging of the leaflet motion and -dynamics throughout heart cycle.
Results: Pending
Discussion: Biomechanical and hemodynamic analysis of the aortic root
remodeling techniques, with and without a supporting ring, will hopefully
provide increased insight in the remodeling technique and provide
knowledge for optimizing surgical procedures for aortic root repair in the
relevant patient groups.
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Ali Mohebbi
Søborg Hovedgade 72A, 3 tv. 2860 Søborg
+4552764078
ali.m92@hotmail.com
Ali Mohebbi, Signe K.D. Engelsholm, Sadasivan Puthusserypady, Troels W. Kjaer, Carsten E.
Thomsen, Helge B.D. Sorensen
Technical University of Denmark, Department of Electrical Engineering
A Brain Computer Interface for Robust Wheelchair Control Application
Based on Pseudorandom Code Modulated Visual Evoked Potential
In this pilot study, a novel and minimalistic Brain Computer Interface (BCI)
based wheelchair control application was developed. In this context, a LEGO
Mindstorm robot was used as a miniature version of a real wheelchair.
By presenting visual stimuli to the eye, desired visual evoked potentials (VEPs)
can be provoked and detected in the electroencephalogram (EEG, one channel).
One useful method for generating detectable EEG patterns (c-VEP) is by coding
the stimulus in repetitive pseudorandom binary sequences. The visual stimuli in
the scheme were generated based on the Gold code, and the VEPs were recognized and classified using subject-specific algorithms.
The intention of the user is identified by comparing recorded real-time EEG
sequences with 4 predefined templates, one for each option provided on the
stimulus display. The options were presented as directional targets indicating
forward, backward, left and right.
When a target was identified by the c-VEP based BCI system, the robot was
controlled corresponding to the directional command. Ten healthy subjects were
evaluated in testing the system where an average accuracy of 97% was
achieved. The promising results illustrate the potential of this approach when
considering a real wheelchair application.
Figure 1 BCI Flow Diagram
Figure 2 Classification Algorithm
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Sissel Bisgaard
Grønningen 9, 4th
28990599
sissel.bisgaars@gmail.com
Authors: Sissel Bisgaard, Bolette Duun-Christensen, Lykke Kempfner, Helge
B.D. Sorensen and Poul Jennum.
Abstract:The purpose of this pilot study was to develop a supportive algorithm
for the detection of idiopathic Rapid Eye-Movement (REM) sleep Behaviour
Disorder (iRBD) from EEG recordings. iRBD is defined as REM sleep without
atonia with no current sign of neurodegenerative disease, and is one of the
earliest known biomarkers of Parkinson's Disease (PD). It is currently
diagnosed by polysomnography (PSG), primarily based on EMG recordings
during REM sleep. The algorithm was developed using data collected from 42
control subjects and 34 iRBD subjects. A feature was developed to represent
high amplitude contents of the EEG and a semi-automatic signal reduction
method was introduced. The reduced feature set was used for a subject-based
classification. With a subject specific re-scaling of the feature set and the use of
an outlier detection classifier the algorithm reached an accuracy of 0.78. The
result shows that EEG recordings contain valid information for a supportive
algorithm for the detection of iRBD. Further investigation could lead to
promising application of EEG recordings as a supportive source for the
detection of iRBD.
SKABELON
Forfatter/Kontakt person: Anders Esager
Adresse: Grønnegade 77 St Th, 8000 Aarhus C
Tlf. nr.: 42524404
E-mail: andersesager@post.au.dk
Anders Esager, Anders Toft Andersen
Aarhus University School of Engineering
CELL SORTER FOR ISOLATION OF INSULIN PRODUCING CELLS
Insulin is a hormone essential for regulating the absorption of glucose. A decrease in insulin production by smaller/fewer pancreatic Langerhans islets may
lead to life-threatening disease, such as diabetes mellitus.
To investigate this disease further, and improve understanding of the
insulin regulation, many pharmaceutical companies perform experiments where
islets are isolated from rats. This is done by surgically removing the pancreas,
dissolving the pancreatic tissue with collagenase treatment and manually picking the islets from the suspension. This procedure is both cumbersome and
time-intensive hence new ways are warranted.
A robotic device was previously developed to pick the islets from the
suspension in a petri dish but the accuracy was inadequate partly due to movements of the pipette in the fluid.
This project aims to develop a novel system for pancreatic islet isolation. First
the pancreas will be dissolved and sucked into a tube. A software program will
be developed to process images taken by a microscope camera. If the islets are
detected a valve mechanism will isolate the islets from the remaining fluid.
This system will help reduce the cost of isolating islets and further reduce variation and damage of the cells.
Fig 1.: System overview
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Mads Olsen; Caspar Aleksander Bang Jespersen
Vesterbrogade X 146B 4tv, 1620; Rosenvængets Alle 27D 3tv, 2100
26180559; 31490999
s101850@student.dtu.dk; s113308@student.dtu.dk
MADS OLSEN & CASPAR ALEKSANDER BANG JESPERSEN
Institute for Biomedical Engineering, Technical University of Denmark
APPNEA: NOVEL SMARTPHONE BASED
APPLICATION FOR SLEEP APNEA DETECTION
This study was a proof of concept for a low cost smart phone based system for
pre-categorization of potential sleep apnea patients is shown. The objective of
the study was to show how the smartphone built-in accelerometer and a bone
conducting microphone can effectively be used to extract features usable in
sleep apnea diagnosis. The results were very promising and certainly prove the
concept. There is however still work to do before a sleep apnea detection application is ready to ship - but this study has laid the foundation.
Poster-konkurrence
Adresse:
Tlf. nr.:
E-mail:
Kathrine Holtz
Svendborgvej 107, st. 5260 Odense M
27585525
kahol09@student.sdu.dk
KATHRINE HOLTZ, LAURA MØLLER HANSEN, HANS HØGENHAVEN,
LARS THOMSEN, STEFFEN HOLMGAARD OG MORTEN
ØSTERGAARD ANDERSEN
The Maersk Mc-Kinney Moller Institute, University of Southern Denmark
EVALUATING THE USE OF EEG FOR MONITORING PATIENTS IN THE
NEUROINTENSIVE CARE UNIT
No one would question the importance of ECG-monitoring of heart patients, but
why are patients with a devastating disease in the brain not EEG-monitored in
the neurointensive care unit (NIA)? This project aimed at identifying the barriers for EEG-monitoring of patients at Odense University Hospital (OUH), suffering from Subarachnoidal hemorrhages (SAH). This was investigated through
interviews with doctors from NIA that were in possession of unused EEG
equipment. The second part of the project was to evaluate the possible use of
this equipment by reviewing literature.
The main barrier was uncertainty of how to interpret the EEG data from the
equipment. Other barriers included staff training and challenges in including
EEG in routine monitoring.
The review uncovered conceptual confusion of SAH complications, but it appears that there is correlation between relative alpha variability of the EEG and
vasospasms, and decreased alpha/delta ratio and delayed cerebral ischemia. We
developed a method for extracting this ratio from clinical EEG data.
Hopefully future research will give clear guidelines on how to monitor the neurointensive patients to predict complications, and give doctors time to react
before deteriorations become irreversible.
Fig. 1: Repeated calibration curves using a steel wire. Note that a small amount
of harmonic content is included at this test velocity.
TILMELDING
Posterkonkurrence
Medicoteknisk landsmøde
Forfatter/kontaktperson:
Adresse:
Tlf. nr.:
E-mail:
Alexander Neergaard Olesen
Nøddebogade 4, 5tv
+45 29840968
alexander.neergaard@gmail.com
ASTRID ENGBERG1, ALEXANDER NEERGAARD OLESEN1 & MORTEN
MØRUP2
1
Department of Electrical Engineering, Technical University of Denmark
Department of Applied Mathematics and Computer Science, Technical University of Denmark
2
NONPARAMETRIC BAYESIAN ANALYSIS OF THE MOUSE BRAIN CONNECTOME
Comprehensive knowledge of brain wiring is essential for a thorough understanding of nervous system functionality. A mesocale connectome
for the murine brain has recently been presented along with a linear model describing the connection strengths between various brain regions. We present an approach for modeling the mouse brain using a directed, unipartite and
weighted network model based on an extended infinite relational model (IRM)
framework where the inter-regional connection strengths are represented using
a Gamma distribution. Statistical inference is carried out using Markov Chain
Monte Carlo methods to determine cluster partitions in the network, thereby
enabling model evaluation through predictive capabilities and normalized mutual information (NMI). The extended IRM is able to extract clusters corresponding to anatomical brain regions (NMI = 0.607±0.014 compared to NMI=
0.277±0.011 for random) using only data. The extended IRM also shows comparable performance to the standard IRM with respect to link prediction (AUC
= 0.885±0.027), and enabled prediction of connection densities between brain
regions (R2 = 0.736). These results indicate that brain connectivity in mice can
be well modeled using a nonparametric Bayesian framework.
SKABELON
Adresse:
Tlf. nr.:
E-mail:
Thomas Lindskow
Nørregade 8, 3.th
25303986
T.lindskow@gmail.com Slet eksempel og skriv abstrakt i testruden: Alle forfattere skal anføres; foredragsholderen skal understreges, max 200 ord: Assessment and comparison of stress distribution in the aortic root:
After aortic root repair using Davids or Yacoubs technique.
- a clinical porcine experimental study
Lindskow T1,3, Tjørnild MJ1,3, Bechsgaard T2,3, Røpcke DM1,3, Lading
TS1,3, Nielsen SL1,3
1
Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital
2
Department of Biomedical Engineering, Aarhus University 3
Clinical Institute of Medicine, Aarhus University Hospital .
Objectives: Recent years of research has showed that aortic valve repair is
superior to valve substitution in patients with aortic regurgitation due to aortic
dilatation if the valve cusps themselves are normal. The aim of this study is to
assess and compare stress distribution in the aortic root after aortic root repair
using two of the most commonly accepted techniques developed by Dr Tirone
E. David (The David valve re-implantation procedure) and Sir Magdi Yacoub
(The Yacoub re-modelling procedure), respectively.
Materials and methods: Fifteen pigs (90 kg) will be randomized to either a
David repair (n=5), a Yocoub repair (n=5) or no repair at all (n=5). A median
sternotomy will be performed and cardiopulmonary bypass will be established
followed by cardioplegia and resection of the aortic root including freedissection of the coronary buttons. Hereafter a force transducer will be sutured to the
aortic annulus just below the valve. This will enable measuring of stress distribution both in plane (annulus dilation/contraction) and out of plane (annulus
bending). Fifteen piezoelectric crystals for sonomicrometric measurements will
be implanted at four levels around the circumference of the aortic root (three at
the annular level, three at each commissure tip, three at the sinotubular junction,
three in the ascending aorta, and one on each free edge of the three aortic
cusps). The sonomicrometric crystals will display 3D geometry of the changes
in the aortic root. Two microtip pressure catheters will be inserted in the left
ventricle and atrium for direct pressure measurements. After weaning from
cardiopulmonary bypass and hemodynamic stabilization, data will be collected
over 10 cardiac cycles.
Force distribution and 3D configuration/behavior of the aortic root will be described and compared between groups.
Results: Results are pending.
Conclusion: With this study we hope to gain more knowledge about the normal
aortic root and also gain insight into different repair techniques, hopefully enabling surgeons to choose the right repair technique for each patient, depending
on pathology and aortic root anatomy.

Foredrags- & Posterkonkurrence Abstracts 2015-6

Transcription

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