PDF bestand VUmc Cancer Center Amsterdam (VUmc CCA)

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PDF bestand VUmc Cancer Center Amsterdam (VUmc CCA)
VUmc Cancer Center Amsterdam
VUmc CCA
Annual Report 2013
Appendices
Address
VUmc Cancer Center Amsterdam (VUmc CCA)
VU University Medical Center
PK 7 Z 182
De Boelelaan 1117
1081 HV Amsterdam
The Netherlands
phone: (31)20 4443113
e-mail: vumc-cca@vumc.nl
website : www.vumc.nl/afdelingen/CCA-V-ICI
Appendix Annual Report 2013 VUmc CCA - 1
List of contents
Appendices
1. Organization
3
2. Scientific input
7
3. Newly started PhD projects
18
4. Scientific output
20
5. Indicators of esteem
60
6. Societal impact
107
7. Ongoing projects
125
8. International collaboration
156
9. Scientific Research Committee
187
10. Evening lectures
199
Appendix Annual Report 2013 VUmc CCA – List of contents - 2
Appendix 1. Organization
Foundation
VUmc CCA
Management Board VUmc CCA
research, patient care, education, regionalization/collaboration, fundraising, communication
Patient care
immunology
Translational &
basic research
Patient care
cancer
Supporting staff
Management Board
Management Board (MB) members:
- G.C.P.M. Hoskens, finance & internal organization (till 1-09-2013)
- P.C. Huijgens, patient care and clinical research oncology, director of VUmc CCA (till 1-10-2013)
- G. Kazemier, PR, communication and fundraising (from 1-10-2013)
- E. van Kessel, finance & internal organization (from 1-09-2013)
- G. Kraal, research immunology, deputy director of VUmc CCA
- C.R. Leemans, education and training
- G.A. Meijer, research cancer (till October 2014)
- B.J. Slotman, regionalisation
- H.M.W. Verheul, PR, communication and fundraising (till 1-10-2013), patients care and clinical
research oncology, director (from 1-10-2013)
- A.E. Voskuijl, patient care and clinical research immunology (from 23-09-2013)
Supportive staff
- C. Addens (secretary)
J. van Diemen (board assistant)
- Y.M. Duiker (board assistant)
- E. van Kessel (project manager)
- M.A.J. Koelink (senior secretary)
- G.K. Kuipers (senior board assistant)
- H. Loeffen (communication advisor)
- E.M. Ruhé (senior board assistant)
- E. Takkenberg (fundraiser)
- B. Volman (project controller) (till 01-03-2013)
- J. Zweers (project controller)
Executive Board
The Executive Board (EB) of VUmc CCA consists of the program leaders. The EB meets every 2
months together with the MB, chaired by one of the MB directors. The EB advises the MB about:
- research projects
- long-term policy with respect to personnel and materials
- first money stream graduate students
- allocation of equipment for research of > € 12.000
- patient care projects
- clinical and translational research
- education
- fundraising for cancer research, care and education
Appendix Annual Report 2013 VUmc CCA – Organization - 3
- early diagnostics
- all matters concerning VUMC CCA whether on request or not.
The complete EB convenes regularly to discuss the long term policy of VUmc CCA.
Executive Board members:
Program 1: Oncogenesis:
- R.H. Brakenhoff
- P.J.F. Snijders
- J. de Winter (till 30-8-2013)
Program 2: Immunopathogenesis:
- R.H.J. Beelen
- T.D. de Gruijl
- E. Hooijberg
- Y. van Kooyk
- R. Mebius
Program 3: Disease profiling:
- G.A.M.S. van Dongen
- O.S. Hoekstra
- C. Jimenez
- C.L. Verweij
- T. Würdinger
Program 4: Innovative therapy:
- R. de Bree
- J. Janssen
- G.J. Peters
- S. Senan
- H. van der Vliet
Program 5: Quality of Life
- J. Dekker
- G.J.L. Kaspers
- B.D. Onwuteaka-Philipsen
- I.M. Verdonck-de Leeuw
- O. Visser
Internal Advisory Board
The members of the internal advisory board consist of 10 – 15 heads of departments involved in
cancer and immunology within the VUmc. The chairman is member of the MB. The board meets
twice a year.
Internal Advisory Board members:
- C.R. Leemans (chair)
- M.A. Blankenstein
- J. Bonjer
- C.D. Dijkstra
- J.J. Heimans
- O.S. Hoekstra
- G.C.P.M. Hoskens
- P.C. Huijgens
- G.G. Kenter
- G. Kraal
- D. de Kruif
- G.A. Meijer
- H. Meijers-Heijboer
- C.J.J. Mulder
- B. Slotman
- E.F. Smit
- H.M.W. Verheul
- A. Voskuyl (on behalf of the department of reumatology)
Appendix Annual Report 2013 VUmc CCA – Organization - 4
Scientific Research Committee (CWO)
The CWO is divided into a section that advises merely animal related protocols (CWO-DEC) and a
section that advises patient related protocols and other project proposals (CWO).
The CWO advises about the research policy and about the feasibility of new research projects upon
request of the MB. The CWO advises the MB specifically about the quality and the feasibility of all
research proposals that need permission of the ethical committees for patient related or animal
related research before they can be realized.
CWO for patient related protocols and other project proposals
Research proposals that are already approved by a Dutch METC outside VUmc are judged only on
local feasibility and if the research fits into the focus points of research. The CWO also advises on
other research proposals for which judgment by the CWO is desired. The CWO gives asked and
unasked advice to the MB about the quality of research within VUMC CCA. The VUMC Management
Regulations stipulate that the VUmc CCA CWO section for patients related protocols is composed of
five to nine members. In view of the institute’s size and in order to have sufficient expertise in the
different research fields, the CWO has been extended to a maximum of 15 members, of which at
least four clinicians (including a pathologist) and two fundamental researchers. Members are
appointed for three years, which can be extended with another three years. The CWO meets twice a
month.
Scientific Research Committee (CWO) members - Section for patient related protocols:
- A.A. van der Loosdrecht (chair)
- A.A. van Bodegraven (till december 2013)
- B.J.M. Braakhuis
- A.J.M. van den Eertwegh
- M. van Egmond
- N. Haasbeek
- N.H. Hendrikse
- D. de Jong
- M. Klein
- G.K. Kuipers (secretary)
- R.D.M. Steenbergen
- W.J.J. Unger
- Q. Waisfisz
CWO for animal related protocols
Animal related protocols that need approval of the animal ethical committee (DEC) of the VUmc are
first evaluated by the CWO DEC committee. The protocols are judged once a month. The CWO DEC is
composed of four to six members.
Scientific Research Committee (CWO) members - Section for animal related protocols:
- R.J. Scheper (chair)
- B.J. Appelmelk
- V.W. van Beusechem
- J.M.M. den Haan (from 03-12-2013)
- G. Kraal
- Y.M. Duiker (secretary)
Committee for Education & Training
The committee for Education and Training supervises and advices about all training and education
activities within VUmc CCA. These activities range from counselling of higher education students,
monitoring and coordinating oncology and immunology education at the (bio)medical Bachelor’s and
Master’s programmes at VU and VUmc, to coordinating graduate and postgraduate education.
The graduate training in oncology is organized within the Oncology Graduate School Amsterdam
(Onderzoekschool Oncologie Amsterdam - OOA).
The committee consists of at least five members, who are all members of VUmc CCA and involved in
educational activities on oncology or immunology. The committee consists of: the management
board member with portfolio ‘education and training’, director OOA, programme director Master’s
Appendix Annual Report 2013 VUmc CCA – Organization - 5
programme in Oncology, the coordinator of the specialisation ‘Immunology’ at FALW and the
education coordinator of bureau VUmc CCA. The committee meets at least four times a year. The
PhD student council (ProPhD) is invited to the meeting when for matters that concern them directly.
Members of the Committee for Education & Training:
- R.H.J. Beelen
- M.M. van Duist
- A.W. Griffioen
- C.R Leemans (chair)
- E.M. Ruhé-Hoogervorst (secretary)
- S. Zweegman
Subgroups:
Oncology profile committee members:
- E. Boven
- B.J.M. Braakhuis
- N.C.T. van Grieken
- A.A. van de Loosdrecht
- E.M. Ruhé-Hoogervorst (profile coordinator)
- F.B.J.M Thunnissen
Immunology and Infection committee members:
- B.J. Appelmelk
- H. Bontkes
- I.E.M. Bultink
- K.A. Gelderman
- I.M.W. van Hoogstraten
- G.K. Kuipers (profile coordinator)
Directorate OOA (Oncology Graduate School Amsterdam)
- A.W. Griffioen
- E.M. Ruhé-Hoogervorst, secretary (VUmc)
- H. te Riele (NKI)
- M. Spaargaren (AMC)
Funding by Stichting VUmc CCA
The Stichting VUmc CCA supports VUmc and VUmc CCA in their cancer research and care for
patients with cancer.
Appendix Annual Report 2013 VUmc CCA – Organization - 6
Appendix 2. Scientific input
Program 1: Oncogenesis
Department
Full professor
Oudejans CBM
de Winter JP
Joenje H
Meijers-Heijboer HE
te Riele H
Kenter GG
Bloemena E
Schulten EAJM
van der Waal I
Brakenhoff RH
Leemans CR
Meijer CJLM
Meijer CJLM
Meijer GA
Middeldorp JM
Mooi WJ
Peeper DS
Snijders PJF
Associate professor
Berkhof J
van de Wiel MA
Dorsman JC
Braakhuis BJM
Heideman DAM
Steenbergen RDM
Steenbergen RDM
van Kemenade F
Assistent professor
Menko FH
van Hest LP
Waisfisz Q
Forouzanfar T
Karagozoglu KH
Bleeker MCG
Carvalho B
Cillessen SAGM
de Jong D
Hooijberg E
Pegtel DM
Rozendaal L
Uyterlinde AM
van Criekinge WMR
Other tenured staff
Gille JJP
Heins YM
Holstege H
Poddighe J
Stoepker C
Oudgenoeg G
Lalic D
Scheffer GL
Total tenured staff
Non tenured staff
Ameziane N
de Lange J
Funding
FTE
Clinical Chemistry
Clinical Genetics
Clinical Genetics
Clinical Genetics
Clinical Genetics
Obstetrics and Gynaecology
Oral and Maxillofacial Surgery and Pathology
Oral and Maxillofacial Surgery and Pathology
Oral and Maxillofacial Surgery and Pathology
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
1
1
1
1
1
1
1
1
1
1
1
3
2
1
1
1
1
1
0,05
0,67
0,20
0,20
0,20
0,33
0,20
0,10
0,10
0,85
0,05
0,16
0,12
0,10
0,50
0,10
0,00
0,60
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Clinical Genetics
Otolaryngology/Head and Neck Surgery
Pathology
Pathology
Pathology
Pathology
1
2
1
1
1
1
2
1
0,70
0,50
0,40
0,85
0,50
0,50
0,04
0,02
Clinical Genetics
Clinical Genetics
Clinical Genetics
Oral and Maxillofacial Surgery and Pathology
Oral and Maxillofacial Surgery and Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
1
1
1
1
1
1
2
3
1
1
3
1
1
2
0,20
0,10
0,20
0,05
0,10
0,20
0,61
1,00
0,20
0,80
0,90
0,10
0,17
0,11
Clinical Genetics
Clinical Genetics
Clinical Genetics
Clinical Genetics
Clinical Genetics
Laboratory Medical Oncology
Pathology
Pathology
1
1
1
1
1
4
3
3
0,10
0,10
0,50
0,10
0,25
0,25
0,83
0,50
15,41
Clinical Genetics
Clinical Genetics
3
3
0,90
0,90
Appendix Annual Report 2013 Vumc CCA – Scientific input - 7
de Wit M
Pham TV
van Beynum JR
Jordanova ES
Nagel R
Stoepker C
Hesselink AT
Wilting SM
PhD students
Adank M
Bakker JL
Dommering CJ
Faramarz A
Haitjema A
Kooi EI
Massink M
Roohollahi K
de Leeuw DC
Neerincx M
Paulis YWJ
Ferns D
Brouns EREA
Dekker H
Dekker H
Ramawadh RS
de Boer DV
Graveland APJ
Hakim S
Martens-de Kemp SR
Martens-de Kemp SR
Rietbergen MM
van Harten AM
Bosch LJW
de Strooper LMA
Hiemstra AC
Hubers J
Luttmer R
Mendeville MS
Miok V
Mollers M
Novalic Z
Ramayanti O
Schütze DM
Snellenberg S
Uijterwaal MH
van Boerdonk R
van Zummeren M
Verhoef VMJ
Verlaat W
Verweij FJ
Haloua JP
Total non tenured staff
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Obstetrics and Gynaecology
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Pathology
Pathology
4
3
3
1
2
3
3
3
0,50
1,00
1,00
0,70
0,50
0,50
1,00
0,83
Clinical Genetics
Clinical Genetics
Clinical Genetics
Clinical Genetics
Clinical Genetics
Clinical Genetics
Clinical Genetics
Clinical Genetics
Laboratory Hematology
Laboratory Medical Oncology
Laboratory Medical Oncology
Obstetrics and Gynaecology
Oral and Maxillofacial Surgery and Pathology
Oral and Maxillofacial Surgery and Pathology
Oral and Maxillofacial Surgery and Pathology
Oral and Maxillofacial Surgery and Pathology
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Surgery
1
1
1
2
3
3
2
1
3
3
3
1
3
4
1
1
3
1
3
3
2
3
3
2
3
1
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
0,07
0,50
0,10
0,75
0,19
0,75
0,75
0,40
0,36
0,63
0,31
0,38
0,00
0,25
0,20
0,16
0,75
0,05
0,31
0,67
0,22
0,44
0,13
0,33
0,75
0,75
0,75
0,75
0,28
0,75
0,69
0,75
0,75
0,06
0,13
0,75
0,63
0,25
0,75
0,44
0,38
0,75
26,89
Total research staff
42,30
Program 2: Immunopathogenesis
Full professor
de Rie MA
Gibbs S
Department
Funding
FTE
Dermatology
Dermatology
1
1
0,01
0,25
Appendix Annual Report 2013 Vumc CCA – Scientific input - 8
Hoekzema R
Starink TM
Mulder CJJ
Bitter W
Vandenbroucke-Grauls CMJE
Beelen RHJ
Dijkstra CD
Kraal G
Mebius RE
van Kooyk Y
Scheper RJ
van den Elsen PJ
von Blomberg BME
Associate professor
de Gruijl TD
Appelmelk BJ
van Die IM
van Egmond M
van Egmond M
Assistent professor
Franken SM
Rustemeyer T
van Montfrans C
de Boer KHN
Felt-Bersma RJF
van Bodegraven AA
van Nieuwkerk CMJ
Ang W
Vainio SJ
van der Sar AM
van den Eertwegh AJM
den Haan JMM
Unger WWJ
Douma CE
Farhat K
Nurmohamed SA
van den Dungen FAM
Mulder MF
van der Kuip M
van der Plas RN
Other tenured staff
Commandeur S
Boks MA
Reijmers RM
van der Steen LPE
van Vliet SJ
Bakema JE
Greijer AE
van Hoogstraten IMW
Total tenured staff
Non tenured staff
Santegoets SJAM
Houben E
Houben E
Ambrosini M
Bakema JE
Garcia-Vallejo JJ
Gul N
Ilarregui JM
Koning JJ
Kuijk LM
Lenos KJ
van de Pavert SA
Dermatology
Dermatology
Gastroenterology
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Pathology
Pathology
Pathology
1
1
1
1
1
1
1
1
1
1
1
1
1
0,10
0,10
0,06
0,40
0,15
0,50
0,05
0,60
0,80
0,60
0,01
0,10
0,03
Laboratory Medical Oncology
Medical Microbiology and Infection Control
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Surgery
1
1
1
1
1
1,00
0,70
0,60
0,80
0,80
Dermatology
Dermatology
Dermatology
Gastroenterology
Gastroenterology
Gastroenterology
Gastroenterology
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Oncology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Nefrology
Nefrology
Nefrology
Neonatology
Paediatrics
Paediatrics
Paediatrics
1
1
1
1
1
1
1
1
1
1
1
2
2
3
3
1
2
1
1
1
0,30
0,30
0,10
0,10
0,20
0,20
0,20
0,10
0,01
0,70
0,05
0,60
1,00
0,10
0,20
0,15
0,20
0,10
0,02
0,00
Medical Microbiology and Infection Control
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Otolaryngology/Head and Neck Surgery
Pathology
Pathology
3
2
2
3
2
1
3
1
0,45
0,40
0,86
0,31
1,00
0,45
0,83
0,10
16,69
Laboratory Medical Oncology
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
2
2
1
3
2
2
3
2
2
3
3
2
0,29
0,35
0,23
1,00
0,45
0,75
0,80
0,78
1,00
0,83
0,67
0,25
Appendix Annual Report 2013 Vumc CCA – Scientific input - 9
Veninga H
Broers CJM
Bontkes HJ
Gelderman KA
PhD students
Kosten IJ
Ates LS
Boot H
van de Weerd R
van Winden VJC
Weerdenburg EM
Lam SW
Aleyd E
Bar-Ephraim J
Beijer MR
Braster R
da Silva Aresta Belo van Wijk AI
Fehres CM
Ferrantelli E
Foster TL
Goverse G
Grewal SK
Klaver EJ
Pires da Silva Baptista A
Stavenuiter AWD
Vila Cuenca M
Walraven M
van Leeuwen LM
Gross S
Rachmawati D
Turksma AW
Total non tenured staff
Molecular Celbiology and Immunology
Paediatrics
Pathology
Pathology
3
1
1
1
1,00
0,20
0,10
0,07
Dermatology
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Oncology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Molecular Celbiology and Immunology
Paediatrics
Pathology
Pathology
Pathology
1
1
3
2
1
1
3
1
1
2
1
3
3
2
2
2
2
1
2
3
3
2
3
3
3
3
0,75
0,75
0,75
0,75
0,19
0,13
0,75
0,75
0,75
0,75
0,75
0,40
0,75
0,75
0,56
0,75
0,75
0,75
0,75
0,75
0,06
0,75
0,14
0,47
0,00
0,34
23,81
Total research staff
40,50
Program 3: Disease profiling
Department
Full professor
Blankenstein MA
Mulder CJJ
Huijgens PC
Kluytmans J
Morré SA
Savelkoul PHM
Vandenbroucke-Grauls CMJE
Dijkstra CD
Heimans JJ
Boellaard R
Comans EFI
Hoekstra OS
Lammertsma AA
van Dongen GAMS
de Bree R
Leemans CR
Bloemena E
Meijer CJLM
Meijer CJLM
Meijer GA
Snijders PJF
van der Waal I
Clinical Chemistry
Gastroenterology
Hematology
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Molecular Celbiology and Immunology
Neurology
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Funding
FTE
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
3
2
1
1
1
0,05
0,06
0,10
0,20
0,40
0,15
0,15
0,05
0,06
0,30
0,05
0,30
0,15
0,75
0,10
0,05
0,20
0,17
0,12
0,10
0,20
0,00
Appendix Annual Report 2013 Vumc CCA – Scientific input - 10
Verweij CL
Verweij CL
Wesseling P
Ylstra B
Postmus PE
Smit EF
Castelijns JA
van Kuijk C
Lems WF
Bonjer HJ
Kazemier G
Associate professor
van de Wiel MA
Jimenez CR
van Beusechem VW
Molthoff CFM
Windhorst AD
Beliën JAM
Ylstra B
Marcus JT
van der Horst-Bruinsma IE
Assistent professor
Zijlstra JM
Budding A
Hekker TAM
Ossenkopp YJ
Smit AM
van der Pouw-Kraan CTM
Postma TJ
Reijneveld JC
Oprea D
Raijmakers PG
van Schie A
Visser GWM
Wang S
Flach GB
Tijink BM
Carvalho B
Fijneman RJA
Thunnissen FBJM
van Grieken NCT
Hendrikse NH
Bahce I
Becker A
Daniels JMA
de Langen AJ
Hashemi SMS
Sutedja TG
van Criekinge WMR
de Graaf P
Duvivier KM
Meijerink MR
van der Bos IC
van Waesberghe JHTM
Bultink IEM
van der Laken CJ
van Schaardenburg D
Voskuyl AE
Paul MA
te Velde EA
Other tenured staff
Crusius JBA
Kaiser AM
Pathology
Pathology
Pathology
Pathology
Pulmonology
Pulmonology
Radiology
Radiology
Reumatology
Surgery
Surgery
1
2
1
1
1
1
1
1
1
1
1
0,30
0,30
0,15
0,06
0,20
0,50
0,20
0,05
0,10
0,20
0,30
Clinical Epidemiology and Biostatistics
Laboratory Medical Oncology
Laboratory Medical Oncology
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Pathology
Pathology
Physics and Medical Technology
Reumatology
2
4
1
1
1
2
1
1
1
0,50
1,00
0,50
0,30
0,30
0,80
0,23
0,05
0,40
Hematology
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Molecular Celbiology and Immunology
Neurology
Neurology
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Pathology
Pathology
Pathology
Pathology
Pharmacy
Pulmonology
Pulmonology
Pulmonology
Pulmonology
Pulmonology
Pulmonology
Pathology
Radiology
Radiology
Radiology
Radiology
Radiology
Reumatology
Reumatology
Reumatology
Reumatology
Surgery
Surgery
1
2
1
1
1
1
1
1
1
1
3
1
4
1
3
2
2
1
1
1
1
1
1
1
1
1
2
1
1
1
1
1
1
4
1
1
1
1
0,20
0,50
0,01
0,01
0,01
0,90
0,10
0,10
0,12
0,05
0,10
0,10
0,75
0,02
0,10
0,31
0,90
0,10
0,20
0,30
0,50
0,10
0,30
0,20
0,20
0,00
0,11
0,03
0,05
0,10
0,10
0,05
0,10
0,20
0,05
0,10
0,10
0,20
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
1
1
0,75
0,05
Appendix Annual Report 2013 Vumc CCA – Scientific input - 11
Karimi O
Ouburg S
Pettersson Fernholm AM
van de Laar TJW
Huisman MC
Poot AJ
Waalboer DCJ
Yaqub MM
Waalboer DCJ
Bierkens M
Blonde W
Blonde W
de Bruijn FDB
Parlayan
Parlayan
Scheffer GL
Sie DLS
Sie DLS
Steegers C
van Denderen AC
Voorham QJM
Schook R
Total tenured staff
Non tenured staff
Verwer E
Vugts D
Poot AJ
Oostlander AE
Johannesma PC
PhD student
Obulkasim A
Obulkasim A
Obulkasim A
Obulkasim A
Vink A
Ben Larbi I
Nijeboer P
Eck Hauer A
Schepens MLM
van der Brand M
le Poole CY
Koekkoek J
van Dellen E
van Thuijl HF
Frings V
Hoyng LL
Makris N
Nissen IA
Oprea D
Rotteveel L
Verbeek J
van der Putten L
Donken R
van Elsland S
Blits M
Bosch LJW
Cordes M
de Groen FLM
de Jong T
de Ridder A
Goos JACM
Krijgsman O
Lubbers J
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Otolaryngology/Head and Neck Surgery
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pulmonology
1
1
1
1
1
4
4
1
4
2
3
2
3
2
1
3
1
1
3
2
2
1
0,01
0,70
0,01
0,02
0,20
0,25
0,81
0,15
0,50
1,00
0,27
0,06
0,40
0,50
0,50
0,50
0,42
0,02
1,00
0,90
1,00
0,46
28,00
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Otolaryngology/Head and Neck Surgery
Pathology
Pulmonology
2
4
2
2
2
1,00
0,90
0,56
0,20
0,42
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Gastroenterology
Gastroenterology
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Medical Microbiology and Infection Control
Nefrology
Neurology
Neurology
Neurology
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Nuclear Medicine and PET Research
Otolaryngology/Head and Neck Surgery
Paediatrics
Paediatrics
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
1
2
1
2
3
2
2
2
2
2
3
4
4
3
2
2
4
2
4
3
2
1
3
4
2
2
3
1
3
2
2
1
2
0,17
0,17
0,17
0,17
0,75
0,33
0,75
0,75
0,75
0,50
0,07
0,10
0,25
0,19
1,00
0,75
0,75
0,69
0,17
0,63
0,75
0,01
0,25
0,75
0,38
0,17
0,75
0,75
0,75
0,75
0,13
0,50
0,75
Appendix Annual Report 2013 Vumc CCA – Scientific input - 12
Ozturk S
Scheinin AI
Timmer LM
van den Broek E
van Thuijl HF
Vosslamber S
Johannesma PC
Kuiper JL
Mellema WW
Paff T
Schook R
Siebring-van Olst E
de Jong MC
Scheffer HJ
John MLB
John MLB
Abis GSA
Abis GSA
de Cuba E
Total non tenured staff
Pathology
Pathology
Pathology
Pathology
Pathology
Pathology
Pulmonology
Pulmonology
Pulmonology
Pulmonology
Pulmonology
Pulmonology
Radiology
Radiology
Reumatology
Reumatology
Surgery
Surgery
Surgery
3
2
3
1
3
3
2
3
3
3
3
1
4
3
1
3
3
1
1
Total research staff
0,30
0,75
0,69
0,75
0,56
0,75
0,44
0,56
0,75
0,75
0,05
0,60
0,75
0,75
0,12
0,12
0,38
0,37
0,56
28,88
56,88
Program 4: Innovative therapy
Department
Full professor
Zuurmond WWA
Boers M
Uyl-de Groot CA
Mulder CJJ
Huijgens PC
Ossenkoppele GJ
van de Loosdrecht AA
Zweegman S
Griffioen AW
Peters GJ
Boven E
Verheul H
Heimans JJ
Vandertop WP
Moll AC
de Bree R
Leemans CR
Scheper RJ
Kaspers GJL
van Furth AM
Senan S
Slotman BJ
Bijlsma JWJ
Boers M
Lems WF
Cuesta MA
Rauwerda JA
van Leeuwen PAM
Wisselink W
van Moorselaar RJA
Associate professor
Perez RSGM
van Agtmael MA
Schuurhuis GJ
Funding
FTE
Anesthesiology
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Gastroenterology
Hematology
Hematology
Hematology
Hematology
Laboratory Medical Oncology
Laboratory Medical Oncology
Medical Oncology
Medical Oncology
Neurology
Neurosurgery
Opthalmonology
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Pathology
Paediatric Oncology
Paediatrics
Radiation Oncology
Radiation Oncology
Reumatology
Reumatology
Reumatology
Surgery
Surgery
Surgery
Surgery
Urology
1
1
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
3
1
1
1
1
1
1
0,20
0,30
0,00
0,06
0,10
0,30
0,30
0,20
0,80
0,80
0,10
0,20
0,06
0,10
0,03
0,10
0,05
0,01
0,10
0,30
0,20
0,20
0,21
0,10
0,10
0,20
0,05
0,10
0,15
0,10
Anesthesiology
Internal Medicine
Laboratory Hematology
1
1
1
0,10
0,90
0,75
Appendix Annual Report 2013 Vumc CCA – Scientific input - 13
van Beusechem VW
Wurdinger T
Assistent professor
Coupe VMH
Menezes R
Menezes R
Chamuleau MED
Issa DE
Janssen JJWM
Meijer E
Thielen N
Visser O
Wondergem MJ
Peters EJG
Cloos J
Buter J
de Jong JM
Konings IRHM
Labots M
van den Eertwegh AJM
van der Houven van Oordt CW
van der Vliet JJ
van der Vorst MJDL
van Linde ME
van Zweeden AA
Voortman J
Postma TJ
Reijneveld JC
Baayen JC
de Witt Hamer PC
Feller RE
Noske DP
Peerdeman SM
van der Meij BS
Eerenstein SEJ
van Weert S
Abbink F
de Haas V
Klein K
Kors WA
Oeij NA
Wilhelm AJ
Dahele MR
Doornaert P
Griffioen GHMJ
Haasbeek CJ
Lagerwaard FJ
Sminia P
Bultink IEM
van Schaardenburg D
Voskuyl AE
Dickhoff C
Hartemink KJ
Meijerink WJ
Oosterhuis JW
Straatman J
van den Tol MP
van der Peet DL
Zonderhuis BM
Geldof AA
ter Haar R
Vis A
Other tenured staff
Laboratory Medical Oncology
Neurosurgery
1
1
0,50
1,00
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Hematology
Hematology
Hematology
Hematology
Hematology
Hematology
Hematology
Internal Medicine
Laboratory Hematology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Neurology
Neurology
Neurosurgery
Neurosurgery
Neurosurgery
Neurosurgery
Neurosurgery
Nutricion and dietics
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Paediatric Oncology
Paediatric Oncology
Paediatric Oncology
Paediatric Oncology
Paediatric Oncology
Pharmacy
Radiation Oncology
Radiation Oncology
Radiation Oncology
Radiation Oncology
Radiation Oncology
Radiation Oncology
Reumatology
Reumatology
Reumatology
Surgery
Surgery
Surgery
Surgery
Surgery
Surgery
Surgery
Surgery
Urology
Urology
Urology
1
1
1
1
4
1
1
4
1
1
1
1
1
3
1
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
0,90
1,00
1,00
0,30
0,40
0,30
0,10
0,40
0,20
0,10
0,10
0,67
0,05
0,04
0,10
0,50
0,05
0,05
0,20
0,17
0,20
0,08
0,20
0,10
0,10
0,05
0,30
0,00
0,30
0,10
0,06
0,02
0,02
0,00
0,00
0,00
0,00
0,00
0,10
0,05
0,05
0,10
0,05
0,05
0,40
0,10
0,05
0,10
0,15
0,40
0,20
0,05
0,07
0,20
0,30
0,05
0,30
0,07
0,10
Appendix Annual Report 2013 Vumc CCA – Scientific input - 14
Bogaards JA
Noordhuis P
Smit L
Smit MA
van Oostveen JW
Broxterman HJ
Galvani E
Giovannetti E
Huijbers EJM
Labots M
Piersma SR
Rovithi MN
van de Ven R
van Pul KM
Visser BM
Warmoes M
Rovithi MN
Berenguer de Felipe J
Langius JAE
Melis GC
Wierdsma NJ
von Mensdorff-Pouilly S
van Battum L
Senthi S
Thijssen VLJL
van Sörnsen de Koste JR
Verbakel WFAR
Al MCM
Jansen G
ter Wee MM
Bossenga J
Bundel EM
Total tenured staff
Non tenured staff
Demirel E
Peeters CFW
Veldhuijzen IK
Honeywell R
van der Stoop PM
Hulleman E
van Tuyl L
Bijnsdorp IV
PhD students
Bongers ML
Chaturvedi N
Greuter MJ
van der Meijde E
de Boer YS
de Koning H
Regelink JC
Wondergem MJ
Sikkens JJ
Cremers E
de Leeuw DC
Kerkhoff N
Niewerth D
Ruben JM
van Alphen C
Verhagen HJMP
Wojtuszkiewicz A
Wouters R
Zeijlemaker W
Avan A
Clinical Epidemiology and Biostatistics
Laboratory Hematology
Laboratory Hematology
Laboratory Hematology
Laboratory Hematology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Medical Oncology
Neurosurgery
Nutricion and dietics
Nutricion and dietics
Nutricion and dietics
Obstetrics and Gynaecology
Physics and Medical Technology
Radiation Oncology
Radiation Oncology
Radiation Oncology
Radiation Oncology
Reumatology
Reumatology
Reumatology
Urology
Urology
3
4
1
4
1
1
4
2
4
3
3
4
3
4
4
4
3
2
3
1
1
1
1
1
1
1
1
1
1
4
1
4
0,30
0,30
0,75
0,02
0,05
1,00
1,00
1,00
0,66
0,10
1,00
0,31
0,06
0,38
0,03
0,30
0,58
1,00
0,33
0,89
0,22
0,10
0,02
0,08
0,60
0,20
0,10
1,00
1,00
0,83
0,10
0,50
34,68
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Laboratory Medical Oncology
Neurosurgery
Paediatric Oncology
Reumatology
Urology
3
3
3
1
2
3
3
3
0,50
0,92
0,90
1,00
0,80
1,00
0,66
1,00
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Clinical Epidemiology and Biostatistics
Gastroenterology
Hematology
Hematology
Hematology
Internal Medicine
Laboratory Hematology
Laboratory Hematology
Laboratory Hematology
Laboratory Hematology
Laboratory Hematology
Laboratory Hematology
Laboratory Hematology
Laboratory Hematology
Laboratory Hematology
Laboratory Hematology
Laboratory Medical Oncology
3
3
3
3
2
4
4
1
3
4
3
3
3
3
3
3
4
3
1
4
0,75
0,75
0,75
0,25
0,75
0,75
0,40
0,07
0,30
0,50
0,37
0,75
0,75
0,06
0,75
0,75
0,75
0,75
0,40
0,75
Appendix Annual Report 2013 Vumc CCA – Scientific input - 15
de Bruin R
Gotink KJ
Hodzic J
Kleibeuker EA
Koster BD
Schulkens I
van der Mijn JC
Weiss A
Huijts L
Kruger DT
Lameris R
Neefjes ECW
Offringa R
Schneiders FL
Versteeg KS
Wentink MQ
Westgeest HM
Koekkoek J
van Dellen E
Hiddingh L
van Rijn S
Buskermolen S
Mourits DL
Klumpers DD
Schmitz MS
Schouten CS
Slobbe P
Blufpand HN
Gordijn MS
Jansen MHA
Janzen J
Sewing ACP
van Vuurden DG
van Vuurden DG
Veldhuijzen van Zanten SEM
Kleibeuker EA
Narayan RS
Tol J
Verstegen NE
Bruijnen STG
Chandrupatla DMSH
Gent YYJ
Konijn NPC
Krieckaert CLM
Rasch LA
Tsang-A-Sjoe MWP
Tsang-A-Sjoe MWP
Ankersmit M
Brinkmann SJH
Buijs N
Nielsen K
Visser M
Total non tenured staff
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Laboratory Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Medical Oncology
Neurology
Neurology
Neurosurgery
Neurosurgery
Nutricion and dietics
Opthalmonology
Orthopaedics
Orthopaedics
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Paediatric Oncology
Paediatric Oncology
Paediatric Oncology
Paediatric Oncology
Paediatric Oncology
Paediatric Oncology
Paediatric Oncology
Paediatric Oncology
Radiation Oncology
Radiation Oncology
Radiation Oncology
Radiation Oncology
Reumatology
Reumatology
Reumatology
Reumatology
Reumatology
Reumatology
Reumatology
Reumatology
Surgery
Surgery
Surgery
Surgery
Surgery
3
3
3
3
3
3
4
4
4
4
3
3
3
1
3
4
3
4
4
3
3
3
3
4
4
2
3
3
3
3
3
3
4
1
3
3
3
3
3
4
3
3
1
1
4
3
1
3
3
3
3
3
Total research staff
0,75
0,13
0,75
0,25
0,44
0,75
0,50
0,25
0,75
0,25
0,25
0,75
0,75
0,25
0,50
0,75
0,63
0,10
0,24
0,75
0,75
0,75
0,75
0,75
0,75
0,44
0,75
0,75
0,75
0,19
0,75
0,75
0,20
0,00
0,75
0,50
0,30
0,60
0,01
0,75
0,72
0,75
0,75
0,01
0,75
0,37
0,37
0,40
0,00
0,75
0,75
0,00
44,78
79,46
Program 5: Quality of life
Department
Full professor
Heimans JJ
Neurology
Funding
FTE
1
0,06
Appendix Annual Report 2013 Vumc CCA – Scientific input - 16
Taphoorn MJB
Festen JM
Leemans CR
Verdonck-de Leeuw IM
Kaspers GJL
Dekker J
Meuleman EJH
Associate professor
Klein M
Assistent professor
van der Linden MHM
van Dijk EM
Reijneveld JC
Rinkel RNPM
van Gogh CDL
Israels T
Veening MA
Other tenured staff
Dirven L
Lubberding S
van den Berg MH
van Litsenburg R
Total tenured staff
Non tenured staff
Mostert SM
van Dulmen-den Broeder E
PhD students
Schuurhuizen C
Boele F
Cnossen IC
Jansen F
Krebber AMH
van Nieuwenhuizen AJ
Braam KI
Al-Itejawi H
Total non tenured staff
Total research staff
Neurology
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Paediatric Oncology
Rehabilitation Medicine
Urology
4
1
1
1
1
1
1
0,01
0,03
0,05
0,60
0,10
0,10
0,10
Medical Psychology
1
0,40
Medical Psychology
Medical Psychology
Neurology
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Paediatric Oncology
Paediatric Oncology
3
3
1
1
1
4
1
0,10
0,30
0,10
0,05
0,02
0,30
0,00
Neurology
Otolaryngology/Head and Neck Surgery
Paediatric Oncology
Paediatric Oncology
1
2
3
4
1,00
0,05
0,60
0,35
4,26
Paediatric Oncology
Paediatric Oncology
4
4
0,60
0,80
Medical Oncology
Medical Psychology
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Otolaryngology/Head and Neck Surgery
Paediatric Oncology
Urology
3
3
3
2
2
3
3
3
0,09
0,24
0,50
0,16
0,61
0,75
0,75
0,25
4,75
9,01
Appendix Annual Report 2013 Vumc CCA – Scientific input - 17
Appendix 3. Newly started PhD projects
PhD student
Project leader
Department
Project
Program
Aleyd E
Van Egmond M
Molecular Celbiology
and Immunology
Immunoglobulin A Fc receptor (Fc-alpha-RI)induced inflammatory diseases
2
Al-Itejawi H
Van Moorselaar
RJA
Urology
De patient centraal bij de behandelkeuze voor
prostaatkanker
5
Chandrupatla
DMSH
Van der Laken CJ
Reumatology
Imaging and targeting of macrophage folate
receptor-beta in rheumatoid arthritis
4
Chondronasiou D
De Gruijl TD
Medical Oncology
Targeting solid tumors and their myeloid
infiltrate by specific nanobodies
4
Cremers E
Van de
Loosdrecht A
Hematology
Emerging role of Flow Cytometry in the
diagnosis of Cytopenias of undetermined
origin (ICUS) and Myelodysplactics Syndromes
4
Donken R
Meijer CJLM
Pathology
HAVANA-studie: HPV amongst vaccinated and
non-vaccinnated adolescents
3
Gootjes EC
Verheul HMW
Medical Oncology
A phase I study of SGI-110 combined with
irinotecan followed by a randomized phase II
study of SGI-110 combined with irinotecan
versus regorafenib in previously treated
metastatic colorectal cancer patients
(CORSICA)
4
Gootjes EC
Verheul HMW
Medical Oncology
A randomized multicenter clinical trial for
patients with multi-ORgan, Colorectal cancer
metastases comparing the combination of
cHEmotherapy and maximal tumor debulking
versuS chemoTheRapy Alone: ORCHESTRA.
4
Jansen F
Verdonck-de
Leeuw IM
Otolaryngology/Head
& Neck Surgery
Cost evaluation of supportive care in head and
neck cancer. Netherlands Quality of Life and
Biomedical Cohort Studies in Head and Neck
Cancer (NET-QUBIC_HNC)
5
Janzen J
Hulleman E
Paediatric Oncology
Growth factors as a target for the treatment of
diffuse intrinsic pontine glioma
4
Kleibeuker EA
Thijssen VLJL
Radiation Oncology
Study on the interaction between angiogenesis
inhibition and radiotherapy
4
Kruger DT
Boven E
Medical Oncology
PI3K pathway analysis in tumor tissue and
circulating DNA to obtain further insight in the
efficacy of evarolimus in combination with
exemestane in postmenopausal patients with
hormone receptor-positive advanced
metastatic breast cancer, who have progressed
on anastrozole or letrozole
3
Lameris R
De Gruijl TD
Medical Oncology
Targeting of CD1d in Multiple Myeloma
4
Masoumi
Kouhestani N
Middeldorp JM
Pathology
Circulating microvesicles containing
inflammatory viral RNA (EBER1) as indicators of
SLE activity and organ involvement
2
Mendeville M
De Jong D
Pathology
Molecular stratification for diffuse large B-cell
lymphoma as a guide for treatment choice.
1
Appendix Annual Report 2013 VUmc CCA – Newly started PhD projects – 18
Rovithi MN
Verheul HMW
Medical Oncology
Clinical evaluation of the underlying
mechanisms of targeted therapy related
toxicities
4
Schuurhuizen C
Verheul HMW
Medical Oncology
Screening and treatment of psychological
distress in colorectal cancer with metastasized
disease (TES)
5
Snoek BC
Snijders PJF
Pathology
Discover and validation of molecular triage
markers to stratify women with hrHPV positive
self-samples for colposcopy directed biopsy by
the gynaecologist
1
Straatman J
Cuesta MA
Surgery
The STOMACH trial: Surgical Technique: Open
versus minimally invasive gastrectomy after
chemotherapy
4
Van der Werf A
Verheul HMW
Nutricion and dietics
The effect of individualized NUTritional
counselling on muscle mass and treatment
outcome in patients with metastatic
COLOrectal cancer undergoing chemotherapy
(COLONUT)
5
Van Harten AM
Brakenhoff RH
Otolaryngology/Head
and Neck Surgery
Development of a personalized targeted
treatment of head and neck cancer
1
Van Helden EJ
Verheul HMW
Medical Oncology
Towards patient tailored cancer treatment
supported by molecular imaging IMPACT:
Imaging Patients for Cancer drug selecTion Metastatic Breast Cancer (IMPACT breast)
4
Van Helden EJ
Verheul HMW
Medical Oncology
Watchful waiting in patients with good and
intermediate risk metastatic renal cell
carcinoma; an imaging guided observational
approach
4
Van Leeuwen LM
Van Furth AM
Paediatrics
The role of the granulomaformation in
tuberculous meningitis in zebrafish
2
Van Thuijl HF
Reijneveld JC
Neurology
Prediction of progression in low-grade glioma
using chromosomal copy number alterations
3
Van Vuurden DG
Cloos J
Paediatric Oncology
Targeted therapy in pediatric brain tumors
4
Van Winden VJC
Bitter W
Medical Microbiology
and Infection Control
Protein secretion systems of M. tuberculosis as
novel target for drug development
2
Van Zummeren M
Verlaat W
Pathology
Snijders PJF
Vila Cuenca M
1
Pathology
Discover and validation of molecular triage
markers to stratify women with hrHPV positive
self-samples for colposcopy directed biopsy by
the gynaecologist
1
Molecular Celbiology
and Immunology
European Training and Research in Peritoneal
Dialysis (EuTRiPD)
2
Westgeest HM
Verheul HMW
Medical Oncology
Castration-resistant Prostate cancer RegIstry
(CAPRI): an observational study in the
Netherlands
4
Westgeest HM
Gerritsen WR
Medical Oncology
Patient Reported Outcomes in the CAstrationresistant Prostate cancer RegIstry: PRO-CAPRI
4
Appendix Annual Report 2013 VUmc CCA – Newly started PhD projects – 19
Appendix 4. Scientific output
Abbreviations:
(x /y):
1:
2:
3:
4:
5:
(Cat.A):
(Cat.B):
(Cat.C):
(Cat.D):
After publications, x: quartile score (1-5), y: Impact Factor of journal
Quartile score: SCI journal from lowest quarter, publications in peer-reviewed journals without an Impact Factor
Quartile score: SCI journal from the second quarter (>25th and < 50th percentile)
Quartile score: SCI journal from the third quarter (>50th and < 75th percentile)
Quartile score: SCI journal belonging to the highest quarter 75th-90th percentile
Quartile score: SCI journal belonging to > 90th percentile
Dissertations prepared and defended at VUmc
Dissertations prepared elsewhere and defended at VUmc
Dissertations prepared at VUmc and defended elsewhere
Dissertations prepared and defended elsewhere
Program 1: Oncogenesis
Scientific papers refereed
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
Adank MA, Verhoef S, Oldenburg RA, Schmidt MK, Hooning MJ, Martens JWM, Broeks A, Rookus M, Waisfisz Q, Witte BI,
Jonker MA, Meijers-Heijboer H. Excess breast cancer risk in first degree relatives of CHEK2*1100delC positive familial
breast cancer cases. Eur J Cancer 2013; 49: 1993-1999 (4/5.061)
Baalbergen A, Smedts F, Ewing P, Snijders PJF, Meijer CJLM, Helmerhorst TJM. HPV-type has no impact on survival of
patients with adenocarcinoma of the uterine cervix. Gynecol Oncol 2013; 128: 530-534 (5/3.929)
Backes DM, Snijders PJF, Hudgens MG, Bailey RC, Bogaarts M, Agot K, Agingu W, Moses S, Meijer CJLM, Smith JS. Sexual
behaviour and less frequent bathing are associated with higher human papillomavirus incidence in a cohort study of
uncircumcised Kenyan men. Sex Transm Infect 2013; 89: 148-155 (3/2.611)
Bakker JL, van Mil SE, Crossan G, Sabbaghian N, De Leeneer K, Poppe B, Adank M, Gille H, Verheul H, Meijers-Heijboer H,
de Winter JP, Claes K, Tischkowitz M, Waisfisz Q. Analysis of the Novel Fanconi Anemia Gene SLX4/FANCP in Familial
Breast Cancer Cases. Hum Mutat 2013; 34: 70-73 (4/5.213)
Bakker ST, de Winter JP, te Riele H. Learning from a paradox: recent insights into Fanconi anaemia through studying
mouse models. Disease Models and Mechanisms 2013; 6: 40-47 (5/4.959)
Berkhof J, Bogaards JA, Demirel E, Diaz M, Sharma M, Kim JJ. Cost-Effectiveness of Cervical Cancer Prevention in Central
and Eastern Europe and Central Asia. Vaccine 2013; 31: H71-H79 (3/3.492)
Bierkens M, Hesselink AT, Meijer CJLM, Heideman DAM, Wisman GB, van der Zee AGJ, Snijders PJF, Steenbergen RDM.
CADM1 and MAL promoter methylation levels in hrHPV-positive cervical scrapes increase proportional to degree and
duration of underlying cervical disease. Int J Cancer 2013; 133: 1293-1299 (4/6.198)
Bierkens M, Krijgsman O, Wilting SM, Bosch LJW, Jaspers A, Meijer GA, Meijer CJLM, Snijders PJF, Ylstra B, Steenbergen
RDM. Focal aberrations indicate EYA2 and hsa-miR-375 as oncogene and tumor suppressor in cervical carcinogenesis.
Gene Chromosom Canc 2013; 52: 56-68 (3/3.546)
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Banos R, Rio P, Knies K, Zuniga S, Benitez J, Bueren JA, Jaspers NGJ, Scharer OD, de Winter JP, Schindler D, Surralles J.
Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi Anemia. Am J Hum Genet 2013; 92:
800-806 (5/11.202)
Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, Hillman
KM, Mai PL, Lawrenson K, Stutz MD, Lu Y, Karevan R, Woods N, Johnstonw RL, French JD, Chen XQ, Weischer M, Nielsen
SF, Maranian MJ, Ghoussaini M, Ahmed S, Baynes C, Bolla MK, Wang Q, Dennis J, McGuffog L, Barrowdale D, Lee A, Healey
S, Lush M, Tessier DC, Vincent D, Bacot F, Vergote I, Lambrechts S, Despierre E, Risch HA, Gonzaalez-Neira A, Rossing
MA, Pita G, Doherty JA, Alvarez N, Larson MC, Fridley BL, Schoof N, Chang-Claude J, Cicek MS, Peto J, Kalli KR, Broeks A,
Armasu SM, Schmidt MK, Braaf LM, Winterhoff B, Nevanlinna H, Konecny GE, Lambrechts D, Rogmann L, Guenel P,
Teoman A, Milne RL, Garcia JJ, Cox A, Shridhar V, Burwinkel B, Marme F, Hein R, Sawyer EJ, Haiman CA, Wang-Gohrke S,
Andrulis IL, Moysich KB, Hopper JL, Odunsi K, Lindblom A, Giles GG, Brenner H, Simard J, Lurie G, Fasching PA, Carney
ME, Radice P, Wilkens LR, Swerdlow A, Goodman MT, Brauch H, Garcia-Closas M, Hillemanns P, Winqvist R, Durst M,
Devilee P, Runnebaum I, Jakubowska A, Lubinski J, Mannermaa A, Meijers-Heijboer EJ, Chenevix-Trench G, Dunning AM.
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian
cancer. Nat Genet 2013; 45: 371-384 (5/35.209)
Bosch FX, Broker TR, Forman D, Moscicki AB, Gillison ML, Doorbar J, Stern PL, Stanley M, Arbyn M, Poljak M, Cuzick J,
Castle PE, Schiller JT, Markowitz LE, Fisher WA, Canfell K, Denny LA, Franco EL, Steben M, Kane MA, Schiffman M, Meijer
CJLM, Sankaranarayanan R, Castellsague X, Kim JJ, Brotons M, Alemany L, Albero G, Diaz M, de Sanjose S. Comprehensive
control of human papillomavirus infections and related diseases. Vaccine 2013; 31: H1-H31 (3/3.492)
Brakenhoff RH. Potentially novel options for treatment of HPV-attributable head and neck cancer. Cell Cycle 2013; 12:
1020-1021 (4/5.243)
Brouns EREA, Baart JA, Bloemena E, Karagozoglu KH, van der Waal I. The relevance of uniform reporting in oral
leukoplakia: Definition, certainty factor and staging based on experience with 275 patients. Med Oral Patol Oral Cir Bucal
2013; 18: E19-E26 (2/1.017)
Couch FJ, Wang XS, McGuffog L, Lee A, Olswold C, Kuchenbaecker KB, Soucy P, Fredericksen Z, Barrowdale D, Dennis J,
Gaudet MM, Dicks E, Kosel M, Healey S, Sinilnikova OM, Bacot F, Vincent D, Hogervorst FBL, Peock S, Stoppa-Lyonnet D,
Jakubowska A, Radice P, Schmutzler RK, Domchek SM, Piedmonte M, Singer CF, Friedman E, Thomassen M, Hansen TVO,
Neuhausen SL, Szabo CI, Blanco I, Greene MH, Karlan BY, Garber J, Phelan CM, Weitzel JN, Montagna M, Olah E, Andrulis
IL, Godwin AK, Yannoukakos D, Goldgar DE, Caldes T, Nevanlinna H, Osorio A, Terry MB, Daly MB, van Rensburg EJ,
Appendix Annual Report 2013 Vumc CCA – Scientific input - 20
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Tischkowitz M, Janavicius R, John EM, Kwong A, Diez O, Balmana J, Barkardottir RB, Arun BK, Rennert G, Teo SH, Ganz PA,
Campbell I, van der Hout AH, van Deurzen CHM, Seynaeve C, Garcia EBG, van Leeuwen FE, Meijers-Heijboer HEJ, Gille JJP,
Ausems MGEM, Blok MJ, Ligtenberg MJL, Rookus MA, Devilee P, Verhoef S, van Os TAM, Wijnen JT, Frost D, Ellis S,
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risk of (pre)malignant cervical lesions in female partners: a retrospective cohort analysis. BJU int 2013; 112: 905-908
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de Kemp SR, Dalm SU, Wijnolts FMJ, van den Brink A, Honeywell RJ, Peters GJ, Braakhuis BJM, Brakenhoff RH. DNA-Bound
Platinum Is the Major Determinant of Cisplatin Sensitivity in Head and Neck Squamous Carcinoma Cells. PLoS One 2013;
8: e61555 (4/3.73)
de Kemp SR, Nagel CR, Stigter-van Walsum M, van der Meulen IH, van Beusechem VW, Braakhuis BJM, Brakenhoff RH.
Functional Genetic Screens Identify Genes Essential for Tumor Cell Survival in Head and Neck and Lung Cancer. Clin
Cancer Res 2013; 19: 1994-2003 (5/7.837)
de Vuyst H, Chung MH, Baussano I, Mugo NR, Tenet V, van Kemenade FJ, Rana FS, Sakr SR, Meijer CJLM, Snijders PJF,
Franceschi S. Comparison of HPV DNA testing in cervical exfoliated cells and tissue biopsies among HIV-positive women
in Kenya. Int J Cancer 2013; 133: 1441-1446 (4/6.198)
den Bakker MA, Thunnissen FBJM. Neuroendocrine tumours-challenges in the diagnosis and classification of pulmonary
neuroendocrine tumours. J Clin Pathol 2013; 66: 862-869 (3/2.439)
Dijkstra JR, Heideman DAM, Meijer GA, Boers JE, 't Hart NA, Diebold J, Hirschmann A, Hoefler G, Winter G, MiltenbergerMiltenyi G, Pereira SV, Richman SD, Quirke P, Rouleau EL, Guinebretiere JM, Tejpar S, Biesmans B, van Krieken JHJM. KRAS
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Garcia-Closas M, Couch FJ, Lindstrom S, Michailidouo K, Schmidt MK, Brook MN, Orr N, Rhie SK, Riboli E, Feigelson HS, Le
Marchand L, Buring JE, Eccles D, Miron P, Fasching PA, Brauch H, Chang-Claude J, Carpenter J, Godwin AK, Nevanlinna H,
Giles GG, Cox A, Hopper JL, Bolla MK, Wang Q, Dennis J, Dicks E, Howat WJ, Schoof N, Bojesen SE, Lambrechts D, Broeks
A, Andrulis IL, Guenel P, Burwinkel B, Sawyer EJ, Hollestelle A, Fletcher O, Winqvist R, Brenner H, Mannermaa A, Hamann
U, Meindl A, Lindblom A, Zheng W, Devillee P, Goldberg MS, Lubinski J, Kristensen V, Swerdlow A, nton-Culver H, Doerk
T, Muir K, Matsuo K, Wu AH, Radice P, Teo SH, Shu XO, Blot W, Kang D, Hartman M, Sangrajrang S, Shen CY, Southey MC,
Park DJ, Hammet F, Stone J, van 't Veer LJ, Rutgers EJ, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Peto J,
Schrauder MG, Ekici AB, Beckmann MW, Silva ID, Johnson N, Warren H, Tomlins I, Kerin MJ, Miller N, Marme F,
Schneeweiss A, Sohn C, Truong T, Laurent-Puig P, Kerbrat P, Nordestgaard BG, Nielsen SF, Flyger H, Milne RL, Perez JIA,
Menendez P, Muller H, Arndt V, Stegmaier C, Lichtner P, Lochmann M, Waisfisz Q, Meijers-Heijboer EJ, Haiman CA, Kraft
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Geraets DT, van Baars R, Alonso I, Ordi J, Torne A, Melchers WJG, Meijer CJLM, Quint WGV. Clinical evaluation of high-risk
HPV detection on self-samples using the indicating FTA-elute solid-carrier cartridge. J Clin Virol 2013; 57: 125-129
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Godinez JM, Heideman DAM, Gheit T, Alemany L, Snijders PJF, Tommasino M, Meijer CJLM, de Sanjose S, Bosch FX, Bravo
IG. Differential presence of Papillomavirus variants in cervical cancer: An analysis for HPV33, HPV45 and HPV58. Infect
Genet Evol 2013; 13: 96-104 (3/2.768)
Graveland AP, Bremmer JF, de Maaker M, Brink A, Cobussen P, Zwart M, Braakhuis BJM, Bloemena E, van der Waal I,
Leemans CR, Brakenhoff RH. Molecular screening of oral precancer. Oral Oncol 2013; 49: 1129-1135 (4/2.695)
Haitjema A, Brandt BW, Ameziane N, May P, Heringa J, de Winter JP, Joenje H, Dorsman JC. A Protein Prioritization
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Heideman DAM, Hesselink AT, van Kemenade FJ, Iftner T, Berkhof J, Topal F, Agard D, Meijer CJLM, Snijders PJF. The
Aptima HPV Assay Fulfills the Cross-Sectional Clinical and Reproducibility Criteria of International Guidelines for Human
Papillomavirus Test Requirements for Cervical Screening. J Clin Microbiol 2013; 51: 3653-3657 (4/4.068)
Hesselink AT, Meijer CJLM, Poljak M, Berkhof J, van Kemenade FJ, van der Salm ML, Bogaarts M, Snijders PJF, Heideman
DAM. Clinical Validation of the Abbott RealTime High Risk HPV Assay According to the Guidelines for Human
Papillomavirus DNA Test Requirements for Cervical Screening. J Clin Microbiol 2013; 51: 2409-2410 (4/4.068)
Hoebe EK, Le Large TYS, Greijer AE, Middeldorp JM. BamHI-A rightward frame 1, an Epstein-Barr virus-encoded oncogene
and immune modulator. Rev Med Virol 2013; 23: 367-383 (5/7.615)
Hoogendam JP, Zaal A, Rutten EGGM, Heijnen CJ, Kenter GG, Veldhuis WB, Verheijen RH, Zweemer RP. Detection of
cervical cancer recurrence during follow-up: A multivariable comparison of 9 frequently investigated serum biomarkers.
Gynecol Oncol 2013; 131: 655-660 (5/3.929)
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Lammers JW, Nackaerts K, van Rosmalen J, Oudkerk M, Koning HJ. Volumetric computed tomography screening for lung
cancer: three rounds of the NELSON trial. Eur Respir J 2013; 42: 1659-1667 (5/6.355)
Huang J, Liu S, Bellani MA, Thazhathveetil AK, Ling C, de Winter JP, Wang YS, Wang WD, Seidman MM. The DNA
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GB, Steenbergen RDM, Lyng H. Identification of eight candidate target genes of the recurrent 3p12-p14 loss in cervical
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Thunnissen E, Ladanyi M. Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine
Kinase Inhibitors Guideline from the College of American Pathologists, International Association for the Study of Lung
Cancer, and Association for Molecular Pathology. J Thoracic Oncol 2013; 8: 823-859 (4/4.473)
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MK, Wang Q, Dicks E, Lee A, Turnbull C, Rahman N, Fletcher O, Peto J, Gibson L, Silva ID, Nevanlinna H, Muranen TA,
Aittomaki K, Blomqvist C, Czene K, Irwanto A, Liu JJ, Waisfisz Q, Meijers-Heijboer H, Adank M, van der Luijt RB, Hein R,
Dahmen N, Beckman L, Meindl A, Schmutzler RK, Muller-Myhsok B, Lichtner P, Hopper JL, Southey MC, Makalic E, Schmidt
DF, Uitterlinden AG, Hofman A, Hunter DJ, Chanock SJ, Vincent D, Bacot F, Tessier DC, Canisius S, Wessels LFA, Haiman
CA, Shah M, Luben R, Brown J, Luccarini C, Schoof N, Humphreys K, Li JM, Nordestgaard BG, Nielsen SF, Flyger H, Couch
FJ, Wang XS, Vachon C, Stevens KN, Lambrechts D, Moisse M, Paridaens R, Christiaens MR, Rudolph A, Nickels S, FleschJanys D, Johnson N, Aitken Z, Aaltonen K, Heikkinen T, Broeks A, van 't Veer LJ, van der Schoot CE, Guenel P, Truong T,
Laurent-Puig P, Menegaux F, Marme F, Schneeweiss A, Sohn C, Burwinke B, Zamora MP, Perez JIA, Pita G, Alonso MR, Cox
A, Brock IW, Cross SS, Reed MWR, Sawyer EJ, Tomlinson I, Kerin MJ, Miller Nao. Large-scale genotyping identifies 41 new
loci associated with breast cancer risk. Nat Genet 2013; 45: 353-361 (5/35.209)
Mollers M, Boot HJ, Vriend HJ, King AJ, Van Den Broek IVF, Van Bergen JEA, Brink AAT, Wolffs PFG, Hoebe CJP, Meijer
CJLM, van der Sande MAB, de Melker HE. Prevalence, incidence and persistence of genital HPV infections in a large cohort
of sexually active young women in the Netherlands. Vaccine 2013; 31: 394-401 (3/3.492)
Mollers M, Vossen JM, Scherpenisse M, van der Klis FRM, Meijer CJLM, de Melker HE. Review: Current knowledge on the
role of HPV antibodies after natural infection and vaccination: Implications for monitoring an HPV vaccination
programme. J Med Virol 2013; 85: 1379-1385 (2/2.373)
Mooij SH, Boot HJ, Speksnijder AGCL, Stolte IG, Meijer CJLM, Snijders PJF, Verhagen DW, King AJ, de Vries HJ, Quint WGV,
van der Sande MAB, van der Loeff MFS. Oral human papillomavirus infection in HIV-negative and HIV-infected MSM. AIDS
2013; 27: 2117-2128 (5/6.407)
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Neerincx M, Buffart TE, Mulder CJJ, Meijer GA, Verheul HMW. The future of colorectal cancer: implications of screening.
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Renier W, Schieving J, Niculescu-Duvaz I, Springer CJ, Kusters B, Wesseling P, Blokx WAM, Marais R. Primary Melanoma of
the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes. Cancer discovery 2013; 3:
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Peng M, Bakker JL, Dicioccio RA, Gille JJ, Zhao H, Odunsi K, Sucheston L, Jaafar L, Mivechi NF, Waisfisz Q, Ko L.
Inactivating Mutations in GT198 in Familial and Early-Onset Breast and Ovarian Cancers. Genes, Chromosomes & Cancer
2013; 4: 15-25 (3/3.546)
Rietbergen MM, Brakenhoff RH, Bloemena E, Witte BI, Snijders PJF, Heideman DAM, Boon D, Koljenovic S, Baatenburg-de
Jong RJ, Leemans CR. Human papillomavirus detection and comorbidity: critical issues in selection of patients with
oropharyngeal cancer for treatment De-escalation trials. Ann Oncol 2013; 24: 2740-2745 (5/7.384)
Rietbergen MM, Leemans CR, Bloemena E, Heideman DAM, Braakhuis BJM, Hesselink AT, Witte BI, de Jong RJB, Meijer
CJLM, Snijders PJF, Brakenhoff RH. Increasing prevalence rates of HPV attributable oropharyngeal squamous cell
carcinomas in the Netherlands as assessed by a validated test algorithm. Int J Cancer 2013; 132: 1565-1571 (4/6.198)
Ruschoff J, Kerr KM, Grote HJ, Middel P, von Heydebreck A, Alves VA, Baldus SE, Buttner R, Carvalho L, Fink L, Jochum W,
Lo AWI, Lopez-Rios F, Marx A, Molina TJ, Olszewski WT, Rieker RJ, Volante M, Thunnissen E, Wrba F, Celik I, Storkel S.
Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung
cancer: round robin test. Arch Pathol Lab Med 2013; 137: 1255-1261 (4/2.781)
Rushlow DE, Mol BM, Kennett JY, Yee S, Pajovic S, Theriault BL, Prigoda-Lee NL, Spencer C, Dimaras H, Corson TW, Pang
R, Massey C, Godbout R, Jiang Z, Zacksenhaus E, Paton K, Moll AC, Houdayer C, Raizis A, Halliday W, Lam WL, Boutros PC,
Lohmann D, Dorsman JC, Gallie BL. Characterisation of retinoblastomas without RB1 mutations: genomic, gene
expression, and clinical studies. Lancet Oncol 2013; 14: 327-334 (5/25.117)
Scherpenisse M, Mollers M, Schepp RM, Meijer CJLM, de Melker HE, Berbers GAM, van der Klis FRM. Detection of systemic
and mucosal HPV-specific IgG and IgA antibodies in adolescent girls one and two years after HPV vaccination. Human
Vaccines & Immunotherapeutics 2013; 9: 314-321 (3/3.136)
Scherpenisse M, Schepp RM, Mollers M, Meijer CJLM, Berbers GAM, van der Klis FRM. Characteristics of HPV-Specific
Antibody Responses Induced by Infection and Vaccination: Cross-Reactivity, Neutralizing Activity, Avidity and IgG
Subclasses. PLoS One 2013; : 8 (4/3.73)
Scherpenisse M, Schepp RM, Mollers M, Mooij SH, Meijer CJLM, Berbers GAM, van der Klis FRM. Comparison of Different
Assays To Assess Human Papillomavirus (HPV) Type 16- and 18-Specific Antibodies after HPV Infection and Vaccination.
Clinical and Vaccine Immunology 2013; 20: 1329-1332 (3/2.598)
Schmeink CE, Massuger LFAG, Lenselink CH, Quint WGV, Witte BI, Berkhof J, Melchers WJG, Bekkers RLM. Prospective
follow-up of 2,065 young unscreened women to study human papillomavirus incidence and clearance. Int J Cancer 2013;
133: 172-181 (4/6.198)
Scholl SM, Kamal M, De KL, Kereszt A, Jordanova ES, Ungureanu S, Berns E, Sastre X. HPV pathway profiling: HPV related
cervical dysplasia and carcinoma studies. Curr Pharm Desigh 2013; 19: 1379-1394 (3/3.311)
Schuster B, Knies K, Stoepker C, Velleuer E, Friedl R, Gottwald-Muhlhauser B, de Winter JP, Schindler D. Whole Exome
Sequencing Reveals Uncommon Mutations in the Recently Identified Fanconi Anemia Gene SLX4/FANCP. Hum Mutat
2013; 34: 93-96 (4/5.213)
Snijders PJF, Verhoef VMJ, Arbyn M, Ogilvie G, Minozzi S, Banzi R, van Kemenade FJ, Heideman DAM, Meijer CJLM. Highrisk HPV testing on self-sampled versus clinician-collected specimens: A review on the clinical accuracy and impact on
population attendance in cervical cancer screening. Int J Cancer 2013; 132: 2223-2236 (4/6.198)
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58. Steenbergen RDM, Ongenaert M, Snellenberg S, Trooskens G, van der Meide WF, Pandey D, Bloushtain-Qimron N, Polyak
K, Meijer CJLM, Snijders PJF, Van Criekinge W. Methylation-specific digital karyotyping of HPV16E6E7-expressing human
keratinocytes identifies novel methylation events in cervical carcinogenesis. J Pathol 2013; 231: 53-62 (5/7.585)
59. Steens A, Wielders CCH, Bogaards JA, Boshuizen HC, de Greeff SC, de Melker HE. Association between human
papillomavirus vaccine uptake and cervical cancer screening in the Netherlands: Implications for future impact on
prevention. Int J Cancer 2013; 132: 932-943 (4/6.198)
60. Swarts DRA, Van Neste L, Henfling MER, Eijkenboom I, Eijk PP, van Velthuysen ML, Vink A, Volante M, Ylstra B, Van
Criekinge W, van Engeland M, Ramaekers FCS, Speel EJ. An exploration of pathways involved in lung carcinoid
progression using gene expression profiling. Carcinogenesis 2013; 34: 2726-2737 (4/5.635)
61. Thunnissen E, Belien JAM, Kerr KM, Chung JH, Flieder DB, Noguchi M, Yatabe Y, Hwang DM, Lelij RJ, Hartemink KJ, MeijerJorna LB, Tsao MS. In compressed lung tissue microscopic sections of adenocarcinoma in situ may mimic papillary
adenocarcinoma. Arch Pathol Lab Med 2013; 137: 1792-1797 (4/2.781)
62. Tome S, Simard JP, Slean MM, Holt I, Morris GE, Wojciechowicz K, te Riele H, Pearson CE. Tissue-specific mismatch repair
protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. DNA Repair 2013; 12: 46-52 (4/4.274)
63. Vaccarella S, de Vuyst H, Mugo NR, Sakr SR, Plummer M, Heideman DAM, Franceschi S, Chung M. Clustering patterns of
human papillomavirus infections among HIV-positive women in Kenya. Infectious Agents and Cancer 2013; 8: (1/0)
64. van Boerdonk RAA, Brokx HAP, Lee P, Kooi C, Postmus PE, Snijders PJF, Grünberg K, Thunnissen E, Sutedja GT, Daniels
JMA, Heideman DAM. Can quantifying free-circulating DNA in plasma be used to identify subjects with high-grade preinvasive endobronchial lesions?. Oncology letters 2013; 5: 1591-1594 (1/0.237)
65. van Boerdonk RAA, Daniels JMA, Bloemena E, Krijgsman O, Steenbergen RDM, Brakenhoff RH, Grünberg K, Ylstra B,
Meijer CJLM, Smit EF, Snijders PJF, Heideman DAM. High-Risk Human Papillomavirus-Positive Lung Cancer Molecular
Evidence for a Pattern of Pulmonary Metastasis. J Thoracic Oncol 2013; 8: 711-718 (4/4.473)
66. van der Groep P, van Diest PJ, Smolders YHCM, Ausems MGEM, van der Luijt RB, Menko FH, Bart J, de Vries EGE, van der
Wall E. HIF-1 alpha Overexpression in Ductal Carcinoma In Situ of the Breast in BRCA1 and BRCA2 Mutation Carriers. PLoS
One 2013; 8: e56055 (4/3.73)
67. van der Putten L, Bloemena E, Merkus P, Hensen EF. Schneiderian papilloma of the temporal bone. BMJ Case Reports
2013; 2013: (1/0)
68. van der Rhee JI, Boonk SE, Putter H, Cannegieter SC, Flinterman LE, Hes FJ, De Snoo FA, Mooi WJ, Gruis NA, Vasen HFA,
Kukutsch NA, Bergman W. Surveillance of Second-Degree Relatives from Melanoma Families with a CDKN2A Germline
Mutation. Cancer Epidem Biomar 2013; 22: 1771-1777 (5/4.559)
69. van Meurs HS, Bleeker MCG, van der Velden J, Overbeek LIH, Kenter GG, Buist MR. The incidence of endometrial
hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a populationbased cohort study. Int J Gynecol Cancer 2013; 23: 1417-1422 (3/1.941)
70. van Wieringen WN, Ros BP, Wilting SM. Modeling the DNA copy number aberration patterns in observational highthroughput cancer data. Stat Appl Genet Mol 2013; 12: 143-174 (4/1.717)
71. van Zeeburg HJT, Graveland AP, Brink A, Nguyen M, Leemans CR, Bloemena E, Braakhuis BJM, Brakenhoff RH. Generation
of precursor cell lines from preneoplastic fields surrounding head and neck cancers. Head Neck-J Sci Spec 2013; 35: 568574 (5/2.833)
72. Vencken PMLH, Reitsma W, Kriege M, Mourits MJE, de Bock GH, de Hullu JA, van Altena AM, Gaarenstroom KN, Vasen
HFA, Adank MA, Schmidt MK, van Beurden M, Zweemer RP, Rijcken F, Slangen BFM, Burger CW, Seynaeve C. Outcome of
BRCA1- compared with BRCA2-associated ovarian cancer: a nationwide study in the Netherlands. Ann Oncol 2013; 24:
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73. Verhoef VMJ, Dijkstra MG, Bosgraaf RP, Hesselink AT, Melchers WJG, Bekkers RLM, Berkhof J, van Kemenade FJ. A second
generation cervico-vaginal lavage device shows similar performance as its preceding version with respect to DNA yield
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74. Vernooij-van Langen AMM, Loeber JG, Elvers B, Triepels RH, Roefs J, Gille JJ, Reijntjens S, Dompeling E, nkert-Roelse JE.
The influence of sex, gestational age, birth weight, blood transfusion, and timing of the heel prick on the pancreatitisassociated protein concentration in newborn screening for cystic fibrosis. J Inherit Metab Dis 2013; 36: 147-154 (4/4.07)
75. Vink MA, Bogaards JA, van Kemenade FJ, de Melker HE, Meijer CJLM, Berkhof J. Clinical progression of high-grade cervical
intraepithelial neoplasia: estimating the time to preclinical cervical cancer from doubly censored national registry data.
Am J Epidemiol 2013; 178: 1161-1169 (5/4.78)
76. Vlenterie M, Flucke U, Hofbauer LC, Timmers HJ, Gastmeier J, Aust DE, van der Graaf WT, Wesseling P, Eisenhofer G,
Lenders JWM. Pheochromocytoma and gastrointestinal stromal tumors in patients with neurofibromatosis type I. Am J
Med 2013; : (5/4.768)
77. Voorham QJM, Janssen J, Tijssen M, Snellenberg S, Mongera S, van Grieken NCT, Grabsch H, Kliment M, Rembacken BJ,
Mulder CJJ, van Engeland M, Meijer GA, Steenbergen RDM, Carvalho B. Promoter methylation of Wnt-antagonists in
polypoid and nonpolypoid colorectal adenomas. BMC Cancer 2013; 2013: (3/3.333)
78. Vriend HJ, Bogaards JA, van der Klis FRM, Scherpenisse M, Boot HJ, King AJ, van der Sande MAB. Patterns of Human
Papillomavirus DNA and Antibody Positivity in Young Males and Females, Suggesting a Site-Specific Natural Course of
Infection. PLoS One 2013; : 8 (4/3.73)
79. Weemaes CMR, van Tol MJD, Wang J, Dam M, van Eggermond MCJA, Thijssen PE, Aytekin C, Brunetti-Pierri N, van der Burg
M, Graham Davies E, Ferster A, Furthner D, Gimelli G, Gennery A, Kloeckener-Gruissem B, Meyn S, Powell C, Reisli I,
Schuetz C, Schulz A, Shugar A, van den Elsen PJ, van der Maarel SM. Heterogeneous clinical presentation in ICF
syndrome: correlation with underlying gene defects. Eur J Hum Genet 2013; 21: 1219-1225 (4/4.319)
80. Wielders EA, Houlleberghs H, Isik G, te Riele H. Functional analysis in mouse embryonic stem cells reveals wild-type
activity for three MSH6 variants found in suspected Lynch syndrome patients. PLoS One 2013; 8: e74766 (4/3.73)
81. Wilting SM, Snijders PJF, Verlaat W, Jaspers A, van de Wiel MA, van Wieringen WN, Meijer GA, Kenter GG, Yi Y, le Sage C,
Agami R, Meijer CJLM, Steenbergen RDM. Altered microRNA expression associated with chromosomal changes
contributes to cervical carcinogenesis. Oncogene 2013; 32: 106-116 (5/7.357)
82. Wilting SM, Verlaat W, Jaspers A, Makazaji NA, Agami R, Meijer CJLM, Snijders PJF, Steenbergen RDM. Methylationmediated transcriptional repression of microRNAs during cervical carcinogenesis. Epigenetics 2013; 8: 220-228 (4/4.92)
Professional publications
1.
Ang CW, Wolfs TFW. Diagnostiek van lymeborreliose bij kinderen. Tijdschr Kindergeneeskd 2013; 81: 126-134.
Appendix Annual Report 2013 Vumc CCA – Scientific input - 23
Dissertations
1.
2.
3.
4.
5.
6.
7.
8.
9.
Adank MA. Clinical impact of breast cancer genes. 11/22/2013. (Co-)promotores: Meijers-Heijboer EJ, Waisfisz Q (cat A)
Bierkens M. Understanding the heterogeneity of high-grade CIN lesions. Chromosomal and epigenetic analysis. Vrije
Universiteit Amsterdam, 1/22/2013. (Co-)promotores: Snijders PJF, Meijer CJLM, Steenbergen RDM (cat A)
Brohet RM. Cancer risks and hormonal modifiers of risks in BRCA1 and BRCA2 mutation carriers. Knowing the genes,
what are the risks? 2/27/2013. (Co-)promotores: van Leeuwen FE, van 't Veer LJ, Rookus MA (cat B)
Cornet I. Studies on mucosal and cutaneous HPV types: the role of genotypes and natural variants in determining their
potential oncogenicity. , 3/14/2013. (Co-)promotores: Snijders PJF, Tommasino M (cat B)
Oort FA. Survival of the FI-Test: Past, present and future of Fecal Inmmunochemical Tests in colorectal cancer screening.
10/28/2013. (Co-)promotores: Mulder CJJ, Meijer GA, van der Hulst RW (cat A)
Rijkaart DC. Impact of HPV testing on cervical cancer screening. 3/1/2013. (Co-)promotores: Meijer CJLM, Snijders PJF,
Heideman DAM, Berkhof J (cat A)
Scherpenisse M. The humoral immune responses after HPV infection and prophylactic vaccination: Importance of
serology. 10/17/2013. (Co-)promotores: Meijer CJLM, van der Klis FRM, Berbers GAM, Noske DP (cat A)
van Harn T. Loss of Rb proteins: Consequences for cell cycle control and genome integrity. 5/17/2013. (Co-)promotores:
te Riele HPJ (cat B)
Zander SAL. Resistance to topoisomerase inhibitors in BRCA1-deficient mouse mammary tumors. Vrije Universiteit
Amsterdam, 1/25/2013. (Co-)promotores: te Riele HPJ, Rotterberg S, Borst P (cat B)
Program 2: Immunopathogenesis
Scientific papers refereed
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
Adriaanse MPM, Tack GJ, Passos VL, Damoiseaux JGMC, Schreurs MWJ, van Wijck K, Riedl RG, Masclee AAM, Buurman WA,
Mulder CJJ, Vreugdenhil ACE. Serum I-FABP as marker for enterocyte damage in coeliac disease and its relation to villous
atrophy and circulating autoantibodies. Aliment Pharm Therap 2013; 37: 482-490 (4/4.548)
Ammerlaan HSM, Harbarth S, Buiting AGM, Crook DW, Fitzpatrick F, Hanberger H, Herwaldt LA, van Keulen PHJ,
Kluijtmans JAJW, Kola A, Kuchenbecker RS, Lingaas E, Meessen N, Morris-Downes MM, Pottinger JM, Rohner P, dos Santos
RP, Seifert H, Wisplinghoff H, Ziesing S, Walker AS, Bonten MJM. Secular Trends in Nosocomial Bloodstream Infections:
Antibiotic-Resistant Bacteria Increase the Total Burden of Infection. Clin Infect Dis 2013; 56: 798-805 (5/9.374)
Andeweg CS, Mulder IM, Felt-Bersma RJF, Verbon A, van der Wilt GJ, van Goor H, Lange JF, Stoker J, Boermeester MA,
Bleichrodt RP. Guidelines of Diagnostics and Treatment of Acute Left-Sided Colonic Diverticulitis. Digestive Surgery 2013;
30: 278-229 (3/1.472)
Arranz E, Pena AS, Bernardo D. Mediators of Inflammation and Immune Responses in the Human Gastrointestinal Tract.
Mediat Inflamm 2013; : 865638 (3/3.882)
az-Gallo LM, Simeon CP, Broen JC, Ortego-Centeno N, Beretta L, Vonk MC, Carreira PE, Vargas S, Roman-Ivorra JA,
Gonzalez-Gay MA, Tolosa C, Lopez-Longo FJ, Espinosa G, Vicente EF, Hesselstrand R, Riemekasten G, Witte T, Distler JHW,
Voskuyl AE, Schuerwegh AJ, Shiels PG, Nordin A, Padyukov L, Hoffmann-Vold AM, Scorza R, Lunardi C, Airo P, van Laar
JM, Hunzelmann N, Gathof BS, Kreuter A, Herrick A, Worthington J, Denton CP, Zhou XD, Arnett FC, Fonseca C, Koeleman
BPC, Assasi S, Radstake TRDJ, Mayes MD, Martin J. Implication of IL-2/IL-21 region in systemic sclerosis genetic
susceptibility. Ann Rheum Dis 2013; 72: 1233-1238 (5/9.111)
Bakker SF, Tushuizen ME, Stokvis-Brantsma WH, Aanstoot HJ, Winterdijk P, van Setten PA, von Blomberg BME, Mulder CJ,
Simsek S. Frequent delay of coeliac disease diagnosis in symptomatic patients with type 1 diabetes mellitus: Clinical and
genetic characteristics. Eur J Intern Med 2013; 24: 456-460 (1/0)
Baptista AP, Olivier BJ, Goverse G, Greuter M, Knippenberg M, Kusser K, Domingues RG, Veiga-Fernandes H, Luster AD,
Lugering A, Randall TD, Cupedo T, Mebius RE. Colonic patch and colonic SILT development are independent and
differentially regulated events. Mucosal Immunology 2013; 6: 511-521 (4/7)
Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, Deane A, Keely S, Horvat JC, Yang M, Oliver BG, van
Rooijen N, Inman MD, Adachi R, Soberman RJ, Hamadi S, Wark PA, Foster PS, Hansbro PM. A new short-term mouse
model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. J Allergy Clin
Immun 2013; 131: 752-762 (5/12.047)
Beijer MR, Molenaar R, Goverse G, Mebius RE, Kraal G, den Haan JMM. A crucial role for retinoic acid in the development
of Notch-dependent murine splenic CD8(-)CD4(-) and CD4(+) dendritic cells. Eur J Immunol 2013; 43: 1608-1616 (4/4.97)
Belo AI, van der Sar AM, Tefsen B, van Die I. Galectin-4 Reduces Migration and Metastasis Formation of Pancreatic Cancer
Cells. PLoS One 2013; 8: e65957 (4/3.73)
Bloem K, Garcia Vallejo JJ, Vuist IM, Cobb BA, van Vliet SJ, van Kooijk Y. Interaction of the Capsular Polysaccharide A from
Bacteroides fragilis with DC-SIGN on Human Dendritic Cells is Necessary for Its Processing and Presentation to T Cells.
Frontiers in Immunology 2013; : 4 (1/0)
Bloem K, Vuist IM, van den Berk M, Klaver EJ, van Die IM, Knippels LM, Garssen J, Garcia Vallejo JJ, van Vliet SJ, van Kooijk
Y. DCIR interacts with ligands from both endogenous and pathogenic origin. Immunol Lett 2013; 158: 33-41 (2/2.337)
Bloem K, Vuist IM, van der Plas AJ, Knippels LMJ, Garssen J, Garcia Vallejo JJ, van Vliet SJ, van Kooijk Y. Ligand Binding and
Signaling of Dendritic Cell Immunoreceptor (DCIR) Is Modulated by the Glycosylation of the Carbohydrate Recognition
Domain. PLoS One 2013; 8: e66266 (4/3.73)
Bom RJM, Matser A, Bruisten SM, van Rooijen MS, Heijman T, Morré SA, de vries HJC, van der Loeff MFS. Multilocus
Sequence Typing of Chlamydia trachomatis Among Men Who Have Sex With Men Reveals Cocirculating Strains Not
Associated With Specific Subpopulations. J Infect Dis 2013; 208: 969-977 (5/5.848)
Boross P, Lohse S, Nederend M, Jansen JHM, van Tetering G, Dechant M, Peipp M, Royle L, Liew LP, Boon L, van Rooijen N,
Bleeker WK, Parren PWHI, Winkel JGJ, Valerius T, Leusen JHW. IgA EGFR antibodies mediate tumour killing in vivo. Embo
Molecular Medicine 2013; 5: 1213-1226 (5/7.795)
Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M,
Zhao ZJ, Bergman A, Merad M, Frenette PS. CD169(+) macrophages provide a niche promoting erythropoiesis under
homeostasis and stress. Nat Med 2013; 19: 429-436 (5/22.864)
Appendix Annual Report 2013 Vumc CCA – Scientific input - 24
17. Conrady CD, Zheng M, Mandal NA, van Rooijen N, Carr DJJ. IFN-alpha-driven CCL2 production recruits inflammatory
monocytes to infection site in mice. Mucosal Immunology 2013; 6: 45-55 (4/7)
18. Conrady CD, Zheng M, van Rooijen N, Drevets DA, Royer D, Alleman A, Carr DJJ. Microglia and a Functional Type I IFN
Pathway Are Required To Counter HSV-1-Driven Brain Lateral Ventricle Enlargement and Encephalitis. J Immunol 2013;
190: 2807-2817 (4/5.52)
19. Cote CH, Bouchard P, van Rooijen N, Marsolais D, Duchesne E. Monocyte depletion increases local proliferation of
macrophage subsets after skeletal muscle injury. BMC Musculoskel Dis 2013; 14: (3/1.875)
20. De Filippo K, Dudeck A, Hasenberg M, Nye E, van Rooijen N, Hartmann K, Gunzer M, Roers A, Hogg N. Mast cell and
macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation.
Blood 2013; 121: 4930-4937 (5/9,06)
21. de Geus ED, Tefsen B, van Haarlem DA, van Eden W, van Die I, Vervelde L. Glycans from avian influenza virus are
recognized by chicken dendritic cells and are targets for the humoral immune response in chicken. Mol Immunol 2013;
56: 452-462 (2/2.645)
22. de Kivita S, Kraneveld AD, Knippels LMJ, van Kooijk Y, Garssen J, Willemsen LEM. Intestinal Epithelium-Derived Galectin-9
Is Involved in the Immunomodulating Effects of Nondigestible Oligosaccharides. J Innate Immunity 2013; 5: 625-638
(4/4.458)
23. de Meij TGJ, Budding AE, Grasman ME, Kneepkens CMF, Savelkoul PHM, Mearin ML. Composition and diversity of the
duodenal mucosa-associated microbiome in children with untreated coeliac disease. Scand J Gastroentero 2013; 48: 530536 (2/2.156)
24. de Meij TGJ, Jharap B, Kneepkens CMF, van Bodegraven AA, de Boer KHN. Long-term follow-up of children exposed
intrauterine to maternal thiopurine therapy during pregnancy in females with inflammatory bowel disease. Aliment
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25. Debels H, Galea L, Han XL, Palmer J, van Rooijen N, Morrison W, Abberton K. Macrophages Play a Key Role in
Angiogenesis and Adipogenesis in a Mouse Tissue Engineering Model. Tissue Engineering Part A 2013; 19: 2615-2625
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26. Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen FX, Jun K, van Rooijen N, Gressens P, Young WL, Su H. Bone Fracture
Exacerbates Murine Ischemic Cerebral Injury. Anesthesiology 2013; 118: 1362-1372 (5/5.163)
27. Degos V, Vacas S, Han ZY, van Rooijen N, Gressens P, Su H, Young WL, Maze M. Depletion of Bone Marrow-derived
Macrophages Perturbs the Innate Immune Response to Surgery and Reduces Postoperative Memory Dysfunction.
Anesthesiology 2013; 118: 527-536 (5/5.163)
28. den Haan JMM, Martinez-Pomares L. Macrophage heterogeneity in lymphoid tissues. Seminars Immunopath 2013; 35:
541-552 (5/5.379)
29. Deppong CM, Bricker TL, Rannals BD, van Rooijen N, Hsieh CS, Green JM. CTLA4Ig Inhibits Effector T Cells through
Regulatory T Cells and TGF-beta. J Immunol 2013; 191: 3082-3089 (4/5.52)
30. Duwaerts CC, Sun EP, Cheng CW, van Rooijen N, Gregory SH. Cross-Activating Invariant NKT Cells and Kupffer Cells
Suppress Cholestatic Liver Injury in a Mouse Model of Biliary Obstruction. PLoS One 2013; : 8 (4/3.73)
31. Eggenhofer E, Popp FC, Mendicino M, Silber P, Hof W, Renner P, Hoogduijn MJ, Pinxteren J, van Rooijen N, Geissler EK,
Deans R, Schlitt HJ, Dahlke MH. Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be
Retransplanted to Secondary Hosts With No Immunosuppression. Stem Cells Translational Medicine 2013; 2: 595-606
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32. Fehres CM, Garcia Vallejo JJ, Unger WWJ, van Kooijk Y. Skin-resident antigen-presenting cells: instruction manual for
vaccine development. Frontiers in Immunology 2013; 4: 157 (1/0)
33. fonso-Barroso A, Clark SO, Williams A, Rosa GT, Nobrega C, Silva-Gomes S, Vale-Costa S, Ummels R, Stoker N,
Movahedzadeh F, van der Ley P, Sloots A, Cot M, Appelmelk BJ, Puzo G, Nigou J, Geurtsen JJG, Appelberg R.
Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in
experimental animal models of infection and have minimal impact on in vitro inflammatory responses. Cell Microbiol
2013; 15: 660-674 (4/4.811)
34. Garcia Vallejo JJ, Ambrosini M, Overbeek A, van Riel WE, Bloem K, Unger WWJ, Chiodo F, Bolscher JG, Nazmi K, Kalay H,
van Kooijk Y. Multivalent glycopeptide dendrimers for the targeted delivery of antigens to dendritic cells. Mol Immunol
2013; 53: 387-397 (2/2.645)
35. Garcia Vallejo JJ, Koning N, Ambrosini M, Kalay H, Vuist I, Sarrami-Forooshani R, Geijtenbeek TBH, van Kooijk Y.
Glycodendrimers prevent HIV transmission via DC-SIGN on dendritic cells. Int Immunol 2013; 25: 221-233 (3/3.135)
36. Garcia Vallejo JJ, Unger WWJ, Kalay H, van Kooijk Y. Glycan-based DC-SIGN targeting to enhance antigen crosspresentation in anticancer vaccines. Oncoimmunol 2013; 2: e23040 (1/0)
37. Garcia Vallejo JJ, van Kooijk Y. The physiological role of DC-SIGN: A tale of mice and men. Trends Immunol 2013; 34:
482-486 (5/9.486)
38. Germano G, Frapolli R, Belgiovine C, Anselmo A, Pesce S, Liguori M, Erba E, Uboldi S, Zucchetti M, Pasqualini F, Nebuloni
M, van Rooijen N, Mortarini R, Beltrame L, Marchini S, Nerini IF, Sanfilippo R, Casali PG, Pilotti S, Galmarini CM, Anichini
A, Mantovani A, D'Incalci M, Allavena P. Role of Macrophage Targeting in the Antitumor Activity of Trabectedin. Cancer
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39. Ghazarian LN, Diana J, Beaudoin L, Larsson PG, Puri RK, van Rooijen N, Flodstrom-Tullberg M, Lehuen A. Protection
Against Type 1 Diabetes Upon Coxsackievirus B4 Infection and iNKT-Cell Stimulation. Diabetes 2013; 62: 3785-3796
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40. Glim JE, Niessen FB, Everts V, van Egmond M, Beelen RHJ. Platelet derived growth factor-CC secreted by M2 macrophages
induces alpha-smooth muscle actin expression by dermal and gingival fibroblasts. Immunobiology 2013; 218: 924-929
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41. Gross S, van Wanrooij RLJ, Nijeboer P, Gelderman KA, Cillessen SAGM, Meijer GA, Mulder CJJ, Bouma G, von Blomberg
BME, Bontkes HJ. Differential IL-13 Production by Small Intestinal Leukocytes in Active Coeliac Disease versus Refractory
Coeliac Disease. Mediat Inflamm 2013; : (3/3.882)
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Scientific publications (books, book chapters, proceedings)
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Cromeyer M, Zaldivar K, Crusius JBA, Pena AS. La enfernedad celiaca en El Salvador; in Rodrigo L, Pena AS, (eds):
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Felt-Bersma R. Een patiënt met rectaal bloedverlies. In: Probleemgeoriënteerd denken bij levensbedreigende situaties.
Een patiënt met rectaal bloedverlies. In: Probleemgeoriënteerd denken bij levensbedreigende situaties. 2013; :
Koning N, Ilarregui JM, Garcia Vallejo JJ, van Kooijk Y. Antigen-Presenting Cells in the Central Nervous System; in
Yamamura T, Gran B, (eds): Multiple Sclerosis Immunology. 2013; : 71-94
Appendix Annual Report 2013 Vumc CCA – Scientific input - 28
6.
7.
van Bodegraven AA, Muris JWM. Idiopathische chronische darmontstekingen; in Mathus-Vliegen EMH, Numans ME, (eds):
Het gastro-enterologie formularium 2013. 2013; 9
van Vliet SJ, van Kooijk Y. How mucins shape antigen-presenting cells to modify immune responses; Mucins and Cancer.
2013; : 108-122
Professional publications
1.
2.
3.
4.
Ang CW, Wolfs TFW. Diagnostiek van lymeborreliose bij kinderen. Tijdschr Kindergeneeskd 2013; 81: 126-134
Baas JDM, Brand HS. Remming van het immuunsysteem door tumoren in het hoofd-halsgebied. Ned Tijdschr Tandheelkd
2013; 120: 143-146
Gelderman KA, Bontkes HJ, Reijm M, de Meij TGJ, Kneepkens CMF, von Blomberg BME, van Hoogstraten IMW.
Confirmation of high levels of transglutaminase-2 antibodies by deamidated gliadin antibodies in the diagnosis of celiac
disease in children: a laboratory perspective. Ned Tijdschr Klin Chem Labgeneeskd 2013; 2013: 193-195
Nijeboer P, Mulder CJJ, Bouma G. Glutensensitiviteit: hype of nieuwe epidemie?. Ned Tijdschr Geneeskd 2013; : 157
Dissertations
1.
2.
3.
4.
5.
6.
7.
8.
9.
Bloem K. C-type lectins and their role in the immune system: New insights into the characteristics of DCIR and DC-SIGN.
11/26/2013. (Co-)promotores: van Kooyk Y, Garssen J, van Vliets SJ, Garcia Vallejo JJ (cat A)
Hiemstra IH. Microbial control of the mucosal barrier function: Implications for local and systemic immune homeostasis.
10/25/2013. (Co-)promotores: Kraal G, den Haan JMM, Bouma G (cat A)
Koning JJ. Mesenchymal stem cells in lymph node development and disease. 1/9/2013. (Co-)promotores: Mebius RE (cat
A)
Pires da Silva Baptista A. Lymphoid Tissue: from Ontogeny to Function. 9/19/2013. (Co-)promotores: Mebius RE (cat A)
Sanders MS. Host genetic variants in susceptibility, severity and outcome of bacterial meningitis. 2/27/2013. (Co)promotores: van Furth AM, Morré SA, Ouburg S (cat A)
Stoop EJM. Mycobacterial factors involved in granuloma formation. 3/22/2013. (Co-)promotores: Bitter W,
Vandenbroucke-Grauls CMJE, van der Sar AM (cat A)
van de Stadt LA. Development of Rheumatoid Arthritis. Preclinical Biomarkers and Prediction. 4/24/2013. (Co-)
promotores: Dijkmans BAC, Aarden LA, van Schaardenburg D (cat B)
van der Woude AD. LOSt and found across the mycobacterial cell envelope. 4/19/2013. (Co-)promotores: Bitter W,
Houber ENG, Luirink J (cat D)
van Hout MWM. FcaRI and neutrophils: Caught in the act. The role of IgA in mucosal immunity. 11/8/2013. (Co-)
promotores: Beelen RHJ, van Egmond M (cat A)
Program 3: Disease profiling
Scientific papers refereed
1.
Aalbers AM, Calado RT, Young NS, Zwaan CM, Kajigaya S, Baruchel A, Geleijns K, de Haas V, Kaspers GJL, Reinhardt D,
Trka J, Kuijpers TW, Pieters R, van der Velden VHJ, van den Heuvel-Eibrink MM. Absence of SBDS mutations in sporadic
paediatric acute myeloid leukaemia. Brit J Haematol 2013; 160: 559-561 (4/4.942)
2. Aalbers AM, Calado RT, Young NS, Zwaan CM, Wu C, Kajigaya S, Coenen EA, Baruchel A, Geleijns K, de Haas V, Kaspers
GJL, Kuijpers TW, Reinhardt D, Trka J, Zimmermann M, Pieters R, van der Velden VHJ, van den Heuvel-Eibrink MM.
Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia. Leukemia 2013; 27: 1786-1789
(5/10.164)
3. Aalbers AM, van den Heuvel-Eibrink MM, de Haas V, te Marvelde JG, de Jong AX, van der Burg M, Dworzak M, Hasle H,
Locatelli F, De Moerloose B, Schmugge M, Stary J, Zecca M, Zwaan CM, van de Loosdrecht AA, van Dongen JJM, Niemeyer
CM, van der Velden VHJ. Applicability of a reproducible flow cytometry scoring system in the diagnosis of refractory
cytopenia of childhood. Leukemia 2013; 27: 1923-1925 (5/10.164)
4. Ades F, de Azambuja E, Daugaard G, Ameye L, Moulin C, Paesmans M, de Jong D, Decoster L, van Greve J, Ismael G,
Moller AK, Piccart M, Awada A. Comparison of a gene expression profiling strategy to standard clinical work-up for
determination of tumour origin in cancer of unknown primary (CUP). J Chemother 2013; 25: 239-246 (1/0.825)
5. Adham M, Greijer AE, Verkuijlen SAWM, Juwana H, Fleig S, Rachmadi L, Malik O, Kurniawan AN, Roezin A, Gondhowiardjo
S, Atmakusumah D, Stevens SJ, Hermani B, Tan IB, Middeldorp JM. Epstein-Barr Virus DNA Load in Nasopharyngeal
Brushings and Whole Blood in Nasopharyngeal Carcinoma Patients before and after Treatment. Clin Cancer Res 2013; 19:
2175-2186 (5/7.837)
6. Albrethsen J, Agner J, Piersma SR, Hojrup P, Pham TV, Weldingh K, Jimenez CR, Andersen P, Rosenkrands I. Proteomic
Profiling of Mycobacterium tuberculosis Identifies Nutrient-starvation-responsive Toxin-antitoxin Systems. Mol Cell
Proteomics 2013; 12: 1180-1191 (5/7.251)
7. Alexiusdottir KK, Snaebjornsson P, Tryggvadottir L, Jonasson L, Olafsdottir EJ, Bjornsson ES, Moller PH, Jonasson JG.
Colon cancer: association of histopathological parameters and patients' survival with clinical presentation. APMIS Acta
pathologica, microbiologica et immunologica Scandinavica 2013; 121: 901-907 (3/2.068)
8. Arnold M, Wildeman MA, Visser O, Karim-Kos HE, Middeldorp JM, Fles R, Tan IB, Coebergh JW. Lower mortality from
nasopharyngeal cancer in The Netherlands since 1970 with differential incidence trends in histopathology. Oral Oncol
2013; 49: 237-243 (4/2.695)
9. Bahce I, Smit EF, Lubberink JM, van der Veldt AAM, Yaqub MM, Windhorst AD, Schuit RC, Thunnissen E, Heideman DAM,
Postmus PE, Lammertsma AA, Hendrikse NH. Development of [C-11]erlotinib Positron Emission Tomography for In Vivo
Evaluation of EGF Receptor Mutational Status. Clin Cancer Res 2013; 19: 183-193 (5/7.837)
10. Bailey DL, Barthel H, Beyer T, Boellaard R, Guckel B, Hellwig D, Herzog H, Pichler BJ, Quick HH, Sabri O, Scheffler K,
Schlemmer HP, Schwenzer NF, Wehrl HF. Summary Report of the First International Workshop on PET/MR Imaging, March
19-23, 2012, Tubingen, Germany. Mol Imaging Biol 2013; 15: 361-371 (4/3.095)
11. Barcelos A, Giovannetti E, de Jonge R, Maftouh M, Griffioen P, Hanauske AR, Peters GJ. Polymorphisms correlated with the
clinical outcome of locally advanced or metastatic colorectal cancer patients treated with ALIRI vs. FOLFIRI. Pteridines
2013; 24: 69-79 (1/0.52)
Appendix Annual Report 2013 Vumc CCA – Scientific input - 29
12. Barwari K, Kummerlin IP, ten Kate FJ, Algaba F, Trias I, Wijkstra H, de la Rosette JJ, Laguna P. What is the added value of
combined core biopsy and fine needle aspiration in the diagnostic process of renal tumours?. World J Urol 2013; 31: 823827 (4/2.888)
13. Bijnsdorp IV, Geldof AA, Lavaei M, Piersma SR, van Moorselaar RJ, Jimenez CR. Exosomal ITGA3 interferes with noncancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. J Extracell
Vesicles 2013; : (1/0)
14. Birgand G, Lepelletier D, Baron G, Barrett S, Breier AC, Buke C, Markovic-Denic L, Gastmeier P, Kluijtmans JAJW,
Lyytikainen O, Sheridan E, Szilagyi E, Tacconelli E, Troillet N, Ravaud P, Lucet JC. Agreement among healthcare
professionals in ten European countries in diagnosing case-vignettes of surgical-site infections. PLoS One 2013; 8:
e68618 (4/3.73)
15. Bleker SM, Bipat S, Spijkerboer AM, van d, V, Stoker J, Kenter GG. The negative predictive value of clinical examination
with or without anesthesia versus magnetic resonance imaging for parametrial infiltration in cervical cancer stages IB1 to
IIA. Int J Gynecol Cancer 2013; 23: 193-198 (3/1.941)
16. Blits M, Jansen G, Assaraf YG, van de Wiel M, Lems WF, Nurmohamed MT, van Schaardenburg D, Voskuyl AE, Wolbink GJ,
Vosslamber S, Verweij CL. Methotrexate Normalizes Up-Regulated Folate Pathway Genes in Rheumatoid Arthritis. Arth
Rheum/Ar C Res 2013; 65: 2791-2802 (4/7.477)
17. Boellaard R. Optimisation and harmonisation: two sides of the same coin?. Eur J Nucl Med Mol I 2013; 40: 982-984
(5/5.114)
18. Boots-Sprenger SHE, Sijben A, Rijntjes J, Tops BBJ, Idema AJ, Rivera AL, Bleeker FE, Gijtenbeek AM, Diefes K, Heathcock L,
Aldape KD, Jeuken JWM, Wesseling P. Significance of complete 1p/19q co-deletion, IDH1 mutation and MGMT promoter
methylation in gliomas: use with caution. Modern Pathol 2013; 26: 922-929 (5/5.253)
19. Bosch T, Verkade E, van Luit M, Pot B, Vauterin P, Burggrave R, Savelkoul PHM, Kluijtmans JAJW, Schouls L. High
Resolution Typing by Whole Genome Mapping Enables Discrimination of LA-MRSA (CC398) Strains and Identification of
Transmission Events. PLoS One 2013; 8: e66493 (4/3.73)
20. Bossini-Castillo L, Martin JE, Broen J, Simeon CP, Beretta L, Gorlova OY, Vonk MC, Ortego-Centeno N, Espinosa G, Carreira
P, de la Pena PG, Oreiro N, Roman-Ivorra JA, Castillo MJ, Gonzalez-Gay MA, Saez-Comet L, Castellvi I, Schuerwegh AJ,
Voskuyl AE, Hoffmann-Vold AM, Hesselstrand R, Nordin A, Lunardi C, Scorza R, van Laar JM, Shiels PG, Herrick A,
Worthington J, Fonseca C, Denton C, Tan FK, Arnett FC, Assassi S, Koeleman BP, Mayes MD, Radstake TRDJ, Martin J.
Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication
study. Ann Rheum Dis 2013; 72: 602-607 (5/9.111)
21. Bovenberg MSS, Degeling MH, Hejazi S, Amante RJ, Keulen M, Jeuken JWM, Akbaripanahi S, Vleggeert-Lankamp CLA,
Tannous M, Wesseling P, Wurdinger T, Tannous BA. Multiplex Blood Reporters for Simultaneous Monitoring of Cellular
Processes. Anal Chem 2013; 85: 10205-10210 (5/5.695)
22. Braakhuis BJM, Graveland AP, Dijk F, Ylstra B, van Wieringen WN, Leemans CR, Brakenhoff RH. Expression signature in
peripheral blood cells for molecular diagnosis of head and neck squamous cell carcinoma. Oral Dis 2013; 19: 452-455
(4/2.377)
23. Buiter HJC, Windhorst AD, Huisman MC, De Maeyer JH, Schuurkes JAJ, Lammertsma AA, Leysen JE. Radiosynthesis and
preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor. EJNMMI research
2013; 3: 24 (5/5.114)
24. Buiter HJC, Windhorst AD, Huisman MC, Yaqub MM, Knol DL, Fisher A, Lammertsma AA, Leysen JE. [11C]AF150(S), an
agonist PET ligand for M1 muscarinic acetylcholine receptors. EJNMMI research 2013; 3: 19 (5/5.114)
25. Buttler RM, Kruit A, Blankenstein MA, Heijboer AC. Measurement of dehydroepiandrosterone sulphate (DHEAS): A
comparison of Isotope-Dilution Liquid Chromatography Tandem Mass Spectrometry (ID-LC-MS/MS) and seven currently
available immunoassays. Clin Chim ACTA 2013; 424: 22-26 (4/2.85)
26. Caponi S, Funel N, Frampton AE, Mosca F, Santarpia L, van der Velde AG, Jiao LR, De Lio N, Falcone A, Kazemier G, Meijer
GA, Verheul HMW, Vasile E, Peters GJ, Boggi U, Giovannetti E. The good, the bad and the ugly: a tale of miR-101, miR-21
and miR-155 in pancreatic intraductal papillary mucinous neoplasms. Ann Oncol 2013; 24: 734-741 (5/7.384)
27. Carmona FD, Cenit MC, az-Gallo LM, Broen JCA, Simeon CP, Carreira PE, Callejas-Rubio JL, Fonollosa V, Lopez-Longo FJ,
Gonzalez-Gay MA, Hunzelmann N, Riemekasten G, Witte T, Kreuter A, Distler JHW, Madhok R, Shiels P, van Laar JM,
Schuerwegh AJ, Vonk MC, Voskuyl AE, Fonseca C, Denton CP, Herrick A, Worthington J, Arnett FC, Tan FK, Assassi S,
Radstake TRDJ, Mayes MD, Martin J. New insight on the Xq28 association with systemic sclerosis. Ann Rheum Dis 2013;
72: 2032-2038 (5/9.111)
28. Carmona FD, Martin JE, Beretta L, Simeon CP, Carreira PE, Callejas JL, Fernandez-Castro M, Saez-Comet L, Beltran E,
Camps MT, Egurbide MV, Airo P, Scorza R, Lunardi C, Hunzelmann N, Riemekasten G, Witte T, Kreuter A, Distler JHW,
Madhok R, Shiels P, van Laar JM, Fonseca C, Denton C, Herrick A, Worthington J, Schuerwegh AJ, Vonk MC, Voskuyl AE,
Radstake TRDJ, Martin J. The Systemic Lupus Erythematosus IRF5 Risk Haplotype Is Associated with Systemic Sclerosis.
PLoS One 2013; 8: e54419 (4/3.73)
29. Carvalho B, Bosch LJW, van Engeland M, Meijer GA. Molecular markers and the future of colorectal cancer screening.
Colorectal Cancer 2013; 2: 95-97 (1/0)
30. Cavaletti G, Cornblath DR, Merkies ISJ, Postma TJ, Rossi E, Frigeni B, Alberti P, Bruna J, Velasco R, Argyriou AA, Kalofonos
HP, Psimaras D, Ricard D, Pace A, Galie E, Briani C, la Torre C, Faber CG, Lalisang RI, Boogerd W, Brandsma D, Koeppen S,
Hense J, Storey D, Kerrigan S, Schenone A, Fabbri S, Valsecchi MG. The chemotherapy-induced peripheral neuropathy
outcome measures standardization study: from consensus to the first validity and reliability findings. Ann Oncol 2013;
24: 454-462 (5/7.384)
31. Chahbouni A, Sinjewel A, den Burger JCG, Vos RM, Wilhelm AJ, Veldkamp AI, Swart EL. Rapid Quantification of
Gabapentin, Pregabalin, and Vigabatrin in Human Serum by Ultraperformance Liquid Chromatography With MassSpectrometric Detection. Ther Drug Monit 2013; 35: 48-53 (3/2.234)
32. Chang C, Middeldorp JM, Yu KJ, Juwana H, Hsu WL, Lou PJ, Wang CP, Chen JY, Liu MY, Pfeiffer RM, Chen CJ, Hildesheim A.
Characterization of ELISA detection of broad-spectrum anti-Epstein-Barr virus antibodies associated with nasopharyngeal
carcinoma. J Med Virol 2013; 85: 524-529 (2/2.373)
33. Chiodo F, Marradi M, Tefsen B, Snippe H, van Die I, Penades S. High Sensitive Detection of Carbohydrate Binding Proteins
in an ELISA-Solid Phase Assay Based on Multivalent Glyconanoparticles. PLoS One 2013; 8: e73027 (4/3.73)
34. Cleynen I, Gonzalez JR, Figueroa C, Franke A, McGovern D, Bortlik M, Crusius JBA, Vecchi M, Artieda M, Szczypiorska M,
Bethge J, Arteta D, Ayala E, Danese S, van Hogezand RA, Panes J, Pena AS, Lukas M, Jewell DP, Schreiber S, Vermeire S,
Appendix Annual Report 2013 Vumc CCA – Scientific input - 30
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42.
43.
44.
45.
46.
47.
48.
49.
50.
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55.
56.
Sans M. Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease
phenotype: results from the IBDchip European Project. Gut 2013; 62: 1556-1565 (5/10.732)
Cohen R, Vugts DJ, Stigter-van Walsum M, Visser GWM, van Dongen GAMS. Inert coupling of IRDye800CW and zirconium89 to monoclonal antibodies for single- or dual-mode fluorescence and PET imaging. Nat Protoc 2013; 8: 1010-1018
(5/7.96)
Corso G, Carvalho J, Marrelli D, Vindigni C, Carvalho B, Seruca R, Roviello F, Oliveira C. Somatic Mutations and Deletions
of the E-Cadherin Gene Predict Poor Survival of Patients With Gastric Cancer. J Clin Oncol 2013; 31: 868-875 (5/18.038)
Cortes A, Hadler J, Pointon JP, Robinson PC, Karaderi T, Leo P, Cremin K, Pryce K, Harris J, Lee S, Joo KB, Shim SC,
Weisman M, Ward M, Zhou XD, Garchon HJ, Chiocchia G, Nossent J, Lie BA, Forre O, Tuomilehto J, Laiho K, Jiang L, Liu Y,
Wu X, Bradbury LA, Elewaut D, Burgos-Vargas R, Stebbings S, Appleton L, Farrah C, Lau J, Kenna TJ, Haroon N, Ferreira
MA, Yang J, Mulero J, Fernandez-Sueiro JL, Gonzalez-Gay MA, Lopez-Larrea C, Deloukas P, Donnelly P, Bowness P, Gafney
K, Gaston H, Gladman DD, Rahman P, Maksymowych WP, Xu HJ, Crusius JBA, van der Horst-Bruinsma IE, Chou CT, ValleOnate R, Romero-Sanchez C, Hansen IM, Pimentel-Santos FM, Inman RD, Videm V, Martin J, Breban M, Reveille JD, Evans
DM, Kim TH, Wordsworth BP, Brown MA. Identification of multiple risk variants for ankylosing spondylitis through highdensity genotyping of immune-related loci. Nat Genet 2013; 45: 730-738 (5/35.209)
Dall'Angelo S, Bandaranayaka N, Windhorst AD, Vugts DJ, van der Born D, Onega M, Schweiger LF, Zanda M, O'Hagan D.
Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[F-18]fluoro-5-deoxyribose as a novel
tracer. Nucl Med Biol 2013; 40: 464-470 (3/2.517)
de Crom SCM, Obihara CC, de Moor RA, Veldkamp EJM, van Furth AM, Rossen JWA. Prospective comparison of the
detection rates of human enterovirus and parechovirus RT-qPCR and viral culture in different pediatric specimens. J Clin
Virol 2013; 58: 449-454 (3/3.287)
de Goede B, Klitsie PJ, van Kempen BJH, Timmermans L, Jeekel J, Kazemier G, Lange JF. Meta-analysis of glue versus
sutured mesh fixation for Lichtenstein inguinal hernia repair. Brit J Surg 2013; 100: 735-742 (5/4.839)
de Goede B, van Kempen BJH, Polak WG, de Knegt RJ, Schouten JNL, Lange JF, Tilanus HW, Metselaar HJ, Kazemier G.
Umbilical hernia management during liver transplantation. Hernia 2013; 17: 515-519 (3/1.693)
de Groot EH, Post N, Boellaard R, Wagenaar NR, Willemsen AT, van Dalen JA. Optimized dose regimen for whole-body
FDG-PET imaging. EJNMMI research 2013; 3: 63 (5/5.114)
De Keersmaecker K, Atak ZK, Li N, Vicente C, Patchett S, Girardi T, Gianfelici V, Geerdens E, Clappier E, Porcu M,
Lahortiga I, Luca R, Yan JK, Hulselmans G, Vranckx H, Vandepoel R, Sweron B, Jacobs K, Mentens N, Wlodarska I,
Cauwelier B, Cloos J, Soulier J, Uyttebroeck A, Bagni C, Hassan BA, Vandenberghe P, Johnson AW, Aerts S, Cools J. Exome
sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.
Nat Genet 2013; 45: 186-190 (5/35.209)
de Kemp SR, Brink A, Stigter-van Walsum M, Damen JMA, Rustenburg F, Wu T, van Wieringen WN, Schuurhuis GJ,
Braakhuis BJM, Slijper M, Brakenhoff RH. CD98 marks a subpopulation of head and neck squamous cell carcinoma cells
with stem cell properties. Stem Cell Res 2013; 10: 477-488 (4/4.467)
de Laat JM, Pieterman CRC, Weijmans M, Hermus AR, Dekkers OM, de Herder WW, van der Horst-Schrivers A, Drent ML,
Bisschop PH, Havekes B, Vriens MR, Valk GD. Low Accuracy of Tumor Markers for Diagnosing Pancreatic Neuroendocrine
Tumors in Multiple Endocrine Neoplasia Type 1 Patients. J Clin Endocr Metab 2013; 98: 4143-4151 (4/6.43)
de Leeuw DC, van den Ancker W, Denkers F, Menezes R, Westers TM, Ossenkoppele GJ, van de Loosdrecht AA, Smit L.
MicroRNA Profiling Can Classify Acute Leukemias of Ambiguous Lineage as Either Acute Myeloid Leukemia or Acute
Lymphoid Leukemia. Clin Cancer Res 2013; 19: 2187-2196 (5/7.837)
de Wit M, Belt EJTH, is-van Diemen PM, Carvalho B, Coupé VMH, Stockmann HBAC, Bril H, Belien JAM, Fijneman RJA, Meijer
GA. Lumican and Versican Are Associated with Good Outcome in Stage II and III Colon Cancer. Ann Surg Oncol 2013; 20:
S348-S359 (5/4.12)
de Wit M, Fijneman RJA, Verheul HMW, Meijer GA, Jimenez CR. Proteomics in colorectal cancer translational research:
Biomarker discovery for clinical applications. Clin Biochem 2013; 46: 466-479 (3/2.45)
Derksen JW, Visser O, de la Riviere GB, Meuleman EJ, Heldeweg EA, Lagerveld BW. Primary urethral carcinoma in females:
an epidemiologic study on demographical factors, histological types, tumour stage and survival. World J Urol 2013; 31:
147-153 (4/2.888)
Dorado-Garcia A, Bos ME, Graveland H, van Cleef BA, Verstappen KM, Kluijtmans JAJW, Wagenaar JA, Heederik DJ. Risk
factors for persistence of livestock-associated MRSA and environmental exposure in veal calf farmers and their family
members: an observational longitudinal study. BMJ open 2013; 3: e003272 (3/1.583)
Douw L, de Groot M, van Dellen E, Aronica E, Heimans JJ, Klein M, Stam CJ, Reijneveld JC, Hillebrand A. Local MEG
networks: The missing link between protein expression and epilepsy in glioma patients?. Neuroimage 2013; 75: 195-203
(5/6.252)
Dukers-Muijrers NHTM, Speksnijder AGCL, Morré SA, Wolffs PFG, van der Sande MAB, Brink AATP, Van Den Broek IVF,
Werner MILS, Hoebe CJPA. Detection of Anorectal and Cervicovaginal Chlamydia Trachomatis Infections following
Azithromycin Treatment: Prospective Cohort Study with Multiple Time-Sequential Measures of rRNA, DNA, Quantitative
Load and Symptoms. PLoS One 2013; : 8 (4/3.73)
Emmink BL, Verheem A, Van Houdt WJ, Steller EJA, Govaert KM, Pham TV, Piersma SR, Rinkes IHMB, Jimenez CR,
Kranenburg O. The secretome of colon cancer stem cells contains drug-metabolizing enzymes. J Proteomics 2013; 91:
84-96 (4/4.088)
Erdem-Eraslan L, Gravendeel LA, de Rooi J, Eilers PHC, Idbaih A, Spliet WGM, den Dunnen WFA, Teepen JL, Wesseling P,
Smitt PAES, Kros JM, Gorlia T, van den Bent MJ, French PJ. Intrinsic Molecular Subtypes of Glioma Are Prognostic and
Predict Benefit From Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Combination With Other
Prognostic Factors in Anaplastic Oligodendroglial Brain Tumors: A Report From EORTC Study 26951. J Clin Oncol 2013;
31: 328-336 (5/18.038)
Farid WRR, de Jonge J, Zondervan PE, Demirkiran A, Metselaar HJ, Tilanus HW, de Bruin RWF, van der Laan LJW, Kazemier
G. Relationship Between the Histological Appearance of the Portal Vein and Development of Ischemic-Type Biliary Lesions
after Liver Transplantation. Liver Transpl 2013; 19: 1088-1098 (5/3.944)
Feller N, van der Velden VHJ, Brooimans RA, Boeckx N, Preijers F, Kelder A, de Greef I, Westra G, te Marvelde JG, Aerts P,
Wind H, Leenders M, Gratama JW, Schuurhuis GJ. Defining consensus leukemia-associated immunophenotypes for
detection of minimal residual disease in acute myeloid leukemia in a multicenter setting. Blood Cancer Journal 2013; 3:
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Appendix Annual Report 2013 Vumc CCA – Scientific input - 31
57. Frampton AE, Gall TMH, Giovannetti E, Stebbing J, Castellano L, Jiao LR, Krell J. Distinct miRNA profiles are associated
with malignant transformation of pancreatic cystic tumors revealing potential biomarkers for clinical use. Expert Review
of Molecular Diagnostics 2013; 13: 325-329 (4/4.089)
58. Frampton AE, Krell J, Kazemier G, Giovannetti E. Serum miR-1290 as a Marker of Pancreatic Cancer-Letter. Clin Cancer
Res 2013; 19: 5250-5251 (5/7.837)
59. Gautschi O, Dingemans AM, Crowe S, Peters S, Roder H, Grigorieva J, Roder J, Zappa F, Pless M, Brutsche M, Baty F,
Bubendorf L, Schmitz SFH, Na KJ, Carbone D, Stahel R, Smit E. VeriStrat (R) has a prognostic value for patients with
advanced non-small cell lung cancer treated with erlotinib and bevacizumab in the first line: Pooled analysis of
SAKK19/05 and NTR528. Lung Cancer 2013; 79: 59-64 (4/3.392)
60. Geelen TH, Rossen JW, Beerens AM, Poort L, Morré SA, Ritmeester WS, van Kruchten HE, van de Pas MM, Savelkoul PHM.
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Scientific papers non-refereed
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Scientific publications (books, book chapters, proceedings)
1.
2.
3.
Tan IB, Haryana SM, de Gast G, Middeldorp JM. Twelve years of KWF (Dutch Cancer Society) funded head and neck cancer
care and research in Indonesia; in Margrath I, (ed): Global health dynamics limited in official association with the
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Verweij CL, Vosslamber S. The interferon system in multiple sclerosis; Towards a personalized medicine approach for
IFNBeta therapy; in Yao Y, (ed): Type I interferon in autoimmune diseases and its clinical applications. Nova Biomedical
Publishers. 2013: 9
Professional publications
1.
Moelans CB, de Groot JS, Steenbergen RDM, Bosch LJW, Carvalho B, van der Wall E, van Diest PJ. Methylering, een
veelbelovende biomarker voor het opsporenvan tumoren in lichaamsvloeistoffen. Kanker Breed 2013; 5: 24-27
Appendix Annual Report 2013 Vumc CCA – Scientific input - 37
2.
3.
4.
5.
Oprea D, Lofgren J, Raijmakers PG, Law I, van Berckel BNM, van der Laken J, van den Bos IC, Kjaer A. Towards
multiparametric medical imaging with PET/MRI: current clinical status. Tijdschr Nucl Geneeskd 2013; 35: 1160-1171
van Dongen GAMS, Hoekstra OS, Lammertsma AA, Vugts DJ, Hendrikse NH, Windhorst AD. PET-beeldvorming in
geneesmiddelenontwikkeling en toepassing. Ned Tijdschr Oncol 2013; 10: 182
Voeten S, Nederhoed JH, bets-Ossenkopp YJ, Zuidema WP. Smartphone draagt ziekten over. Med Contact 2013; 2013:
2510-2511
Yaqub MM, Oprea D, Hofman MBM, Boellaard R. Methodological aspects of PET/MR imaging. Tijdschr Nucl Geneeskd
2013; 35: 1153-1159
Dissertations
1.
2.
3.
4.
Bosch LJW. Molecular markers for colorectal cancer screening and prediction of response to therapy. 4/25/2013. (Co-)
promotores: Meijer GA, van Engeland M, Carvalho B (cat A)
de Wit M. Protein biomarkers for clinical application in colorectal cancer. 10/4/2013. (Co-)promotores: Meijer GA,
Fijneman RJA, Jimenez CR (cat A)
Huijsmans CJJ. Nucleotide variations in the human genome: Suitable markers for tissue identification and allelic
instability testing. 10/22/2013. (Co-)promotores: Savelkoul RHM (cat B)
Voorham QJM. Molecular Characterization of Nonpolypoid Colorectal Adenomas. 9/12/2013. (Co-)promotores: Meijer
GA, Mulder CJJ, Carvalho B, van Engeland M (cat A)
Program 4: Innovative therapy
Scientific papers refereed
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2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
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Decontamination of the Digestive Tract in Gastrointestinal Surgery: Useful in Infection Prevention? A Systematic Review. J
Gastrointest Surg 2013; 17: 2172-2178 (4/2.361)
Abouyahya I, Alhan C, Westers TM, te Boekhorst PA, Kappers-Klunne MC, Coenen JL, Heyning FH, Huls GA, de Wolf JT,
Imholz AL, Koene HR, Veth G, de Kruijf EJFM, Muus P, Planken EV, Segeren CM, Vasmel WL, van der Velden AM, Velders
GA, Koedam J, Ossenkoppele GJ, van de Loosdrecht AA. Treatment with lenalidomide in myelodysplastic syndromes with
deletion 5q: results from the Dutch named patient program. Leukemia Lymphoma 2013; 54: 874-877 (2/2.301)
Aerts JG, Codrington H, Lankheet NAG, Burgers S, Biesma B, Dingemans AMC, Vincent AD, Dalesio O, Groen HJM, Smit EF.
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Jacobs MAJM, Mulder CJJ. Designing an Endoscopy unit. South African Gastroenterology Review 2013; 11: 2
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van der Waal I, Leemans CR. Aandoeningen van de mondholte; in de Vries N, van de Heyning PH, Leemans CR, (eds):
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Boot J, Rump BO, Boucher CAB, Op de Coul ELM, van Agtmael MA, van de Vijver DAMC, Burger DM, Fanoy EB. Preexpositieprofylaxe van seksuele hiv-transmissie; nieuwe preventiestrategie met tenofovir/emtricitabine. Ned Tijdschr
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de Bree R. Positronemissietomografie als voorspeller van de behandeluitkomst bij hoofd-halskanker. Ned Tijdschr Oncol
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Moghimi M, Forouzanfar T, Karagozoglu KH, Schulten EAJM. Een fulminant beloop van een dentogene ontsteking. Ned
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Morré SA, Ouburg S. Chlamydia trachomatis infections and subfertility: activities of the EpiGenChlamydia Consortium and
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33. Wilhelm AJ, van Erp NP, Janssen JJWM. Therapeutic Drug Monitoring van tyrosinekinaseremmers bij chronische myeloide
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Jacobs J, Bultink IEM, Voskuyl AE. SLE en botontkalking: Resultaten van langetermijnonderzoek naar botontkalking bij
SLE-patiënten. NVLE venster 2013; 33: 6-7
van Montfrans C. Kweekhuid tegen chronisch open wonden. 2013
van Montfrans C. Huidvervanging bij chronische open wonden. 2013
van Montfrans C. Levende pleister als booster voor de slecht genezende wond. Ned Tijdschr Wondverzorging 2013; 4
Wiericx A, Ouburg S, Morré SA. Heb jij een werkend anti-soa eiwit? 2013
Dissertations
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de Groot M. Epilepsy in brain tumor patients: towards improved and personalized treatment. 2/8/2013. (Co-)promotores:
Heimans JJ, Reijneveld JC, Aronica E (cat A)
de Jonge RCJ. Predicting the long-term outcome of bacterial meningitis in childhood. 9/30/2013. (Co-)promotores: van
Furth AM, Gemke RJBJ, Terwee CB (cat A)
de Leest HTJI. Helicobacter pylori and non-steroidal anti-flammatory drugs in patients with rheumatic diseases.
4/21/2013. (Co-)promotores: Lems WF, Dijkmans BAC, Boers M (cat A)
de Vries MK. New insights into anti-TNF treatment of ankylosing spondylitis. 2/1/2013. (Co-)promotores: Dijkmans BAC,
van der Horst-Bruinsma (cat A)
Gordijn MS. Neuroendocrine and Psychosocial Consequences of Childhood Acute Lymphoblastic Leukemia and
Lymphoma. 12/2/2013. (Co-)promotores: Kaspers GJL, Gemke RJBJ, Rotteveel J (cat A)
Heusschen R. The role of galectins in the vasculature. 11/11/2013. (Co-)promotores: Griffioen AW, Thijssen VLJL (cat A)
Jamnitski A. Rheumatoid arthritis and psoriatic arthritis: Important aspects for daily clinical practice. 11/8/2013. (Co-)
promotores: Dijkmans BAC, Lems WF, Nurmohamed MT, Wolbink GJ (cat B)
Klarenbeek NB. Targeted treatment in early rheumaoid arthritis. 3/21/2013. (Co-)promotores: Huizinga TWJ, Lems WF
(cat D)
Krekel NMA. Advances in breast cancer surgery: The decisive role of intra-operative ultrasound. Vrije Universiteit
Amsterdam, 1/18/2013. (Co-)promotores: Meijer S, van den Tol MP, Winters HAH (cat A)
Krieckaert CLM. Pharmacokinetics and immunogenicity of TNF-inhibitors, towards optimised treatment of rheumatoid
arthritis. 9/25/2013. (Co-)promotores: Lems WF (cat B)
Phernambucq ECJ. Combined Modality Treatment for Locally-Advanced Non-Small-Cell Lung Cancer: The ongoing search
for optimal management. 7/1/2013. (Co-)promotores: Smit EF, Senan S (cat A)
Raterman HG. Rheumatoid Arthritis: The link between thyroid dysfunction, cardiovascular disease and B cell targeting.
9/16/2013. (Co-)promotores: Dijkmans BAC (cat A)
Rodrigues G. Novel radiotherapy approaches and prognostic models in brain metastases. 10/2/2013. (Co-)promotores:
Senan S, Lagerwaard FJ (cat B)
Terwijn M. Minimal Residual Disease and Leukemic Stem Cell Detection in Acute Myeloid Leukemia: New Approaches for
Clinical Decision Making. 4/12/2013. (Co-)promotores: Ossenkoppele GJ, Schuurhuis GJ (cat A)
Turksma AW. Preclinical studies on immunotherapeutic approaches for the treatment of solid tumors. 11/21/2013. (Co-)
promotores: Meijer CJLM, Leemans CR, Hooijberg E, Bloemena E (cat A)
van Dellen E. Lesions in the connected brain. A network perspective on brain tumors and lesional epilepsy. 6/4/2013.
(Co-)promotores: Stam CJ, Heimans JJ, Reijneveld JC, Douw L (cat A)
van den Ancker W. Immunodiagnostics and immune surveillance in an era of evolving immunotherapeutic strategies in
AML. 11/29/2013. (Co-)promotores: Ossenkoppele GJ, van de Loosdrecht AA, de Gruijl TD, Westers TM (cat A)
van den Boezem PB. Implementation of single-port surgery and notes in clinical practice. 2/5/2013. (Co-)promotores:
Cuesta MA, Sietses C (cat B)
van den Broek M. Treat to target in rheumatoid arthritis: opportunities and outcomes. 9/24/2013. (Co-)promotores:
Huizinga TWJ, Lems WF (cat D)
Visser O. Hematopoietic stem cell transplantation in B- and T-cell lymphoma. 3/28/2013. (Co-)promotores: Huijgens PC,
Mulder CJJ, van Dongen GAMS, Zijlstra-Baalbergen JM (cat A)
Program 5: Quality of life
Scientific papers refereed
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6.
Andersson J, Angenete E, Gellerstedt M, Angeras U, Jess P, Rosenberg J, Furst A, Bonjer HJ, Haglind E. Health-related
quality of life after laparoscopic and open surgery for rectal cancer in a randomized trial. Brit J Surg 2013; 100: 941-949
(5/4.839)
Bakker SF, Pouwer F, Tushuizen ME, Hoogma RP, Mulder CJ, Simsek S. Compromised quality of life in patients with both
Type1 diabetes mellitus and coeliac disease. Diabetic Med 2013; 30: 835-839 (3/3.241)
Boele FW, Douw L, de Groot M, van Thuijl HF, Cleijne W, Heimans JJ, Taphoorn MJB, Reijneveld JC, Klein M. The effect of
modafinil on fatigue, cognitive functioning, and mood in primary brain tumor patients: a multicenter randomized
controlled trial. Neuro-oncology 2013; 15: 1420-1428 (5/6.18)
Boele FW, Heimans JJ, Aaronson NK, Taphoorn MJB, Postma TJ, Reijneveld JC, Klein M. Health-related quality of life of
significant others of patients with malignant CNS versus non-CNS tumors: a comparative study. J Neuro-Oncol 2013; 115:
87-94 (3/3.115)
Boele FW, Hoeben W, Hilverda K, Lenting J, Calis AL, Sizoo EM, Collette EH, Heimans JJ, Taphoorn MJB, Reijneveld JC, Klein
M. Enhancing quality of life and mastery of informal caregivers of high-grade glioma patients: a randomized controlled
trial. J Neuro-Oncol 2013; 111: 303-311 (3/3.115)
Boers M, Buttgereit F. A simple model that suggests possible cost savings when modified-release prednisone 5 mg/day is
added to current treatment in patients with active rheumatoid arthritis. Rheumatology 2013; 52: 1435-1437 (4/4.212)
Appendix Annual Report 2013 Vumc CCA – Scientific input - 56
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31.
Boers-Doets CB, Gelderblom H, Lacouture ME, Bredle JM, Epstein JB, Schrama NAWP, Gall HE, Ouwerkerk J, Brakenhoff
JAC, Nortier JWR, Kaptein AA. Translation and linguistic validation of the FACT-EGFRI-18 quality of life instrument from
English into Dutch. Eur J Oncol Nurs 2013; 17: 802-807 (4/1.685)
Braam KI, van der Torre P, Takken T, Veening MA, den Broeder E, Kaspers GJL. Physical exercise training interventions for
children and young adults during and after treatment for childhood cancer. Cochrane Database Syst Rev 2013; :
CD008796 (5/5.7031)
Buffart LM, Kalter J, Chinapaw MJM, Heijmans MW, Aaronson NK, Courney KS, Jacobsen PB, Newton RU, Verdonck-de
Leeuw IM, Brug J. Predicting Optimal cancer rehabilitation and supportive care(POLARIS); Rationale and design for metaanalyses of individual patient data of randomized controlled trials evaluating the effect of exercise and psychosocial
interventions on health-related quality of life in cancer survivors. Systematic Reviews 2013; 2: (1/0)
Davies A, Buchanan A, Zeppetella G, Porta-Sales J, Likar R, Weismayr W, Slama O, Korhonen T, Filbet M, Poulain P,
Mystakidou K, Ardavanis A, O'Brien T, Wilkinson P, Caraceni A, Zucco F, Zuurmond W, Andersen S, Damkier A, Vejlgaard
T, Nauck F, Radbruch L, Sjolund KF, Stenberg M. Breakthrough Cancer Pain: An Observational Study of 1000 European
Oncology Patients. J Pain Symptom Manag 2013; 46: 619-628 (4/2.601)
de Bruijn MJ, Rinkel RN, Cnossen IC, Witte BI, Langendijk JA, Leemans CR, Verdonck-de Leeuw IM. Associations between
voice quality and swallowing function in patients treated for oral or oropharyngeal cancer. Support Care Cancer 2013;
21: 2025-2032 (5/2.649)
de Groot M, Douw L, Sizoo EM, Bosma I, Froklage FE, Heimans JJ, Postma TJ, Klein M, Reijneveld JC. Levetiracetam
improves verbal memory in high-grade glioma patients. Neuro-oncology 2013; 15: 216-223 (5/6.18)
de Vos J, Menko FH, Oosterwijk JC, van Asperen CJ, Stiggelbout AM, Tibben A. Genetic counseling does not fulfill the
counselees' need for certainty in hereditary breast/ovarian cancer families: an explorative assessment. Psycho-Oncol
2013; 22: 1167-1176 (5/3.506)
de Vos J, van Asperen CJ, Oosterwijk JC, Menko FH, Collee MJ, Garcia EG, Tibben A. The counselees' self-reported request
for psychological help in genetic counseling for hereditary breast/ovarian cancer: not only psychopathology matters.
Psycho-Oncol 2013; 22: 902-910 (5/3.506)
de Vries MC, Bresters D, Kaspers GJL, Houtlosser M, Wit JM, Engberts DP, van Leeuwen E. What constitutes the best
interest of a child? Views of parents, children, and physicians in a pediatric oncology setting. AJOB Primary Research
2013; 4 (2): 1-10 (1/0)
Deganello A, Gitti G, Struijs B, Paiar F, Gallo O. Palliative combined treatment for unresectable cutaneous basosquamous
cell carcinoma of the head and neck. Acta Otorhinolaryngol Ital 2013; 33: 353-356 (1/0.786)
Dekker J, Beekman ATF, Boenink AD, Bomhof-Roordink H, Braamse AM, Collette EH, Huijgens PC, van der Linden MHM,
van Meijel B, Snoek FJ, Visser O, Verheul HM. Comment on 'Psychological distress in patients with cancer: is screening
the effective solution?'. Brit J Cancer 2013; 108: 2628-2630 (4/5.082)
Demirdas S, Maurice-Stam H, Boelen CCA, Hofstede FC, Janssen MCH, Langendonk JG, Mulder MF, Rubio-Gozalbo ME, van
Spronsen FJ, de Vries M, Grootenhuis MA, Bosch AM. Evaluation of quality of life in PKU before and after introducing
tetrahydrobiopterin (BH4), a prospective multi-center cohort study. Mol Genet Metab 2013; 110: S49-S56 (3/2.834)
Dirven L, Reijneveld JC, Aaronson NK, Bottomley A, Uitdehaag BMJ, Taphoorn MJB. Health-related Quality of Life in
Patients with Brain Tumors: Limitations and Additional Outcome Measures. Current Neurology and neuroscience reports
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Ediebah DE, Coens C, Maringwa JT, Quinten C, Zikos E, Ringash J, King M, Gotay C, Flechtner HH, von Koch JS, Weis J,
Smit EF, Kohne CH, Bottomley A. Effect of completion-time windows in the analysis of health-related quality of life
outcomes in cancer patients. Ann Oncol 2013; 24: 231-237 (5/7.384)
Eeltink CM, Incrocci L, Witte BI, Meurs S, Visser O, Huijgens PC, Verdonck-de Leeuw IM. Fertility and sexual function in
female Hodgkin lymphoma survivors of reproductive age. J Clin Nursing 2013; 22: 3513-3521 (4/1.316)
Flechl B, Ackerl M, Sax C, Oberndorfer S, Calabek B, Sizoo E, Reijneveld J, Crevenna R, Keilani M, Gaiger A, Dieckmann K,
Preusser M, Taphoorn MJB, Marosi C. The caregivers' perspective on the end-of-life phase of glioblastoma patients. J
Neuro-Oncol 2013; 112: 403-411 (3/3.115)
Garssen B, Boomsma MF, Meezenbroek ED, Porsild T, Berkhof J, Berbee M, Visser A, Meijer S, Beelen RHJ. Stress
management training for breast cancer surgery patients. Psycho-Oncol 2013; 22: 572-580 (5/3.506)
Gordijn MS, Gemke RJBJ, Bierings MB, Hoogerbrugge PM, Tersteeg-Kamperman MDJ, Heijnen CJ, Rotteveel J, Kaspers GJL.
Adequate endocrine and cardiovascular response to social stress in survivors of childhood acute lymphoblastic leukemia.
Psychoneuroendocrino 2013; 38: 3145-3149 (5/5.137)
Gordijn MS, van Litsenburg RRL, Gemke RJ, Huisman J, Bierings MB, Hoogerbrugge PM, Kaspers GJL. Sleep, fatigue,
depression, and quality of life in survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2013; 60:
479-485 (4/2.353)
Gorter RR, Vos CG, Halmans J, Hartemink KJ, Paul MA, Oosterhuis JWA. Evaluation of arm function and quality of life after
trimodality treatment for superior sulcus tumours. Interactive Cardiovascular and Thoracic Surgery 2013; 16: 44-48 (1/0)
Haverman L, van Rossum MAJ, van Veenendaal M, ten Berg JM, Dolman KM, Swart JF, Kuijpers TW, Grootenhuis MA.
Effectiveness of a Web-Based Application to Monitor Health-Related Quality of Life. Pediatrics 2013; 131: E533-E543
(5/5.119)
Henneman L, Oosterwijk JC, van Asperen CJ, Menko FH, Ockhuysen-Vermey CF, Kostense PJ, Claassen L, Timmermans
DRM. The effectiveness of a graphical presentation in addition to a frequency format in the context of familial breast
cancer risk communication: a multicenter controlled trial. BMC Medical Informatics and Decision Making 2013; : 13
(2/1.603)
Hensgens TB, Bloemer E, Schouten-van Meeteren AYN, Zwaan CM, Bos C, Huyser C, Kaspers GJL. Psychiatric symptoms
causing delay in diagnosing childhood cancer: two case reports and literature review. Eur Child Adoles Psy 2013; 22:
443-450 (5/3.699)
Hiligsmann M, Cooper C, Arden N, Boers M, Branco JC, Brandi ML, Bruyere O, Guillemin F, Hochberg MC, Hunter DJ, Kanis
JA, Kvien TK, Laslop A, Pelletier JP, Pinto D, Reiter-Niesert S, Rizzoli R, Rovati LC, Severens JLH, Silverman S, Tsouderos Y,
Tugwell P, Reginster JY. Health economics in the field of osteoarthritis: An Expert's consensus paper from the European
Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheu 2013; 43:
303-313 (3/3.806)
Jans SMPJ, Henneman L, de Jonge J, van El CG, van Tuyl LH, Cornel MC, Lagro-Janssen ALM. A morass of considerations:
exploring attitudes towards ethnicity-based haemoglobinopathy-carrier screening in primary care. Fam Pract 2013; 30:
604-610 (4/1.828)
Appendix Annual Report 2013 Vumc CCA – Scientific input - 57
32. Keyzer-Dekker CMG, de VJ, Mertens MC, Roukema JA, van der Steeg AFW. Cancer or no cancer: the influence of trait
anxiety and diagnosis on quality of life with breast cancer and benign disease: a prospective, longitudinal study. World J
Surg 2013; 37: 2140-2147 (3/2.228)
33. Knijnenburg SL, Kremer LC, Versluys AB, Braam KI, Mud MS, van der Pal HJ, Caron HN, Jaspers MW. Evaluation of a patient
information website for childhood cancer survivors. Support Care Cancer 2013; 21: 919-926 (5/2.649)
34. Langius JAE, Bakker S, Rietveld DHF, Kruizenga HM, Langendijk JA, Weijs PJM, Leemans CR. Critical weight loss is a major
prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy. Brit J
Cancer 2013; 109: 1093-1099 (4/5.082)
35. Langius JAE, van Dijk AM, Doornaert PAH, Kruizenga HM, Langendijk JA, Leemans CR, Weijs PJM, Verdonck-de Leeuw IM.
More than 10% weight loss in head and neck cancer patients during radiotherapy is independently associated with
deterioration in quality of life. Nutr Cancer 2013; 65: 76-83 (3/2.695)
36. Langius JAE, Zandbergen MC, Eerenstein SEJ, van Tulder MW, Leemans CR, Kramer MHH, Weijs PJM. Effect of nutritional
interventions on nutritional status, quality of life and mortality in patients with head and neck cancer receiving (chemo)
radiotherapy: a systematic review. Clin Nutr 2013; 32: 671-678 (3/3.298)
37. Leistra E, Langius JAE, van Bokhorst-de van der Schueren, Visser M, de Vet HCW, Kruizenga HM. Validity of nutritional
screening with MUST and SNAQ in hospital outpatients. Eur J Clin Nutr 2013; 67: 738-742 (3/2.756)
38. Ligthart-Melis GC, Weijs PJM, te Boveldt ND, Buskermolen S, Earthman CP, Verheul HMW, de Lange-de Klerk ESM, van
Weyenberg SJB, van der Peet DL. Dietician-delivered intensive nutritional support is associated with a decrease in severe
postoperative complications after surgery in patients with esophageal cancer. Dis Esophagus 2013; 26: 587-593
(2/1.642)
39. Mellema WW, Dingemans AMC, Thunnissen E, Snijders PJF, Derks J, Heideman DAM, van Suylen R, Smit EF. KRAS
Mutations in Advanced Nonsquamous Non-Small-Cell Lung Cancer Patients Treated with First-Line Platinum-Based
Chemotherapy Have No Predictive Value. J Thoracic Oncol 2013; 8: 1190-1195 (4/4.473)
40. Neefjes ECW, van der Vorst MJDL, Blauwhoff-Buskermolen S, Verheul HMW. Aiming for a Better Understanding and
Management of Cancer-Related Fatigue. Oncologist 2013; 18: 1135-1143 (3/4.095)
41. Oerlemans S, Mols F, Issa DE, Pruijt JHFM, Peters WG, Lybeert M, Zijlstra W, Coebergh JWW, van de Poll-Franse L. A high
level of fatigue among long-term survivors of non-Hodgkin's lymphoma: results from the longitudinal population-based
PROFILES registry in the south of the Netherlands. Haematol-Hematol J 2013; 98: 479-486 (4/5.935)
42. Oskam IM, Verdonck-de Leeuw IM, Aaronson NK, Witte BI, de Bree R, Doornaert P, Langendijk JA, Leemans CR.
Prospective evaluation of health-related quality of life in long-term oral and oropharyngeal cancer survivors and the
perceived need for supportive care. Oral Oncol 2013; 49: 443-448 (4/2.695)
43. Overbeek A, van den Berg MH, Hukkelhoven CWPM, Kremer LC, van den Heuvel-Eibrink MM, Tissing WJE, Loonen JJ,
Versluys AB, Bresters D, Kaspers GJL, Lambalk CB, van Leeuwen FE, den Broeder E. Validity of self-reported data on
pregnancies for childhood cancer survivors: a comparison with data from a nationwide population-based registry. Hum
Reprod 2013; 28: 819-827 (5/4.67)
44. Petersen MA, Aaronson NK, Arraras JI, Chie WC, Conroy T, Costantini A, Giesinger JM, Holzner B, King MT, Singer S,
Velikova G, Verdonck-de Leeuw IM, Young T, Groenvold M. The EORTC computer-adaptive tests measuring physical
functioning and fatigue exhibited high levels of measurement precision and efficiency. J Clin Epidemiol 2013; 66: 330339 (5/5.332)
45. Petersen MA, Giesinger JM, Holzner B, Arraras JI, Conroy T, Gamper EM, King MT, Verdonck-de Leeuw IM, Young T,
Groenvold M. Psychometric evaluation of the EORTC computerized adaptive test (CAT) fatigue item pool. Qual Life Res
2013; 22: 2443-2454 (4/2.412)
46. Pieterse QD, Kenter GG, Maas CP, de Kroon CD, Creutzberg CL, Trimbos JB, ter Kuile MM. Self-reported sexual, bowel and
bladder function in cervical cancer patients following different treatment modalities: longitudinal prospective cohort
study. Int J Gynecol Cancer 2013; 23: 1717-1725 (3/1.941)
47. Pistilli B, Bellettini G, Giovannetti E, Codacci-Pisanelli G, Azim HA, Benedetti G, Sarno MA, Peccatori FA. Chemotherapy,
targeted agents, antiemetics and growth-factors in human milk: How should we counsel cancer patients about
breastfeeding?. Cancer Treat Rev 2013; 39: 207-211 (4/6.024)
48. Schook RM, Linssen C, Festen JM, Schramel FMNH, Lammers E, Zaanen P, Postmus PE. Website visitors asking questions
online to lung cancer specialists: what do they want to know?. Interactive Journal of Medical Research 2013; 2: e15 (1/0)
49. Singer S, Arraras JI, Baumann I, Boehm A, Chie WC, Galalae R, Langendijk JA, Guntinas-Lichius O, Hammerlid E, Pinto M,
Nicolatou-Galitis O, Schmalz C, Sen M, Sherman AC, Spiegel K, Verdonck-de Leeuw IM, Yarom N, Zotti P, Hofmeister D.
Quality of life in patients with head and neck cancer receiving targeted or multimodal therapy - Update of the EORTC
QLQ-H & N35, Phase I. Head Neck-J Sci Spec 2013; 35: 1331-1338 (5/2.833)
50. Singer S, Arraras JI, Chie WC, Fisher SE, Galalae R, Hammerlid E, Nicolatou-Galitis O, Schmalz C, Verdonck-de Leeuw IM,
Gamper E, Keszte J, Hofmeister D. Performance of the EORTC questionnaire for the assessment of quality of life in head
and neck cancer patients EORTC QLQ-H&N35: a methodological review. Qual Life Res 2013; 22: 1927-1941 (4/2.412)
51. Sitaresmi MN, Mostert S, Gundy CM, Ismail D, Veerman AJP. A medication diary-book for pediatric patients with acute
lymphoblastic leukemia in Indonesia. Pediatr Blood Cancer 2013; 60: 1593-1597 (4/2.353)
52. Sizoo EM, Taphoorn MJB, Uitdehaag BMJ, Heimans JJ, Deliens L, Reijneveld JC, Pasman HRW. The End-of-Life Phase of
High-Grade Glioma Patients: Dying With Dignity?. Oncologist 2013; 18: 198-203 (3/4.095)
53. Slee-Valentijn MS, Maier AB. Comprehensive Geriatric Assessment and Adjustment of Cancer Treatment. Oncologist
2013; 18: 1330 (3/4.095)
54. Tong WH, van der Sluis IM, Alleman CJM, van Litsenburg RRL, Kaspers GJL, Pieters R, Uyl-de Groot CA. Cost-analysis of
treatment of childhood acute lymphoblastic leukemia with asparaginase preparations: the impact of expensive
chemotherapy. Haematol-Hematol J 2013; 98: 753-759 (4/5.935)
55. Uden-Kraan CF, Chinapaw MJM, Drossaert CH, Verdonck-de Leeuw IM, Buffart LM. Cancer patients' experiences with and
perceived outcomes of yoga: results from focus groups. Support Care Cancer 2013; 21: 1861-1870 (5/2.649)
56. van Bruinessen IR, van Weel-Baumgarten EM, Gouw H, Zijlstra JM, Albada A, van Dulmen S. Barriers and facilitators to
effective communication experienced by patients with malignant lymphoma at all stages after diagnosis. Psycho-Oncol
2013; 22: 2807-2814 (5/3.506)
57. van der Meij BS, de Graaf P, Wierdsma NJ, Langius JAE, Janssen JJWM, van Leeuwen PAM, Visser OJ. Nutritional support in
patients with GVHD of the digestive tract: state of the art. Bone Marrow Transpl 2013; 48: 474-482 (3/3.541)
Appendix Annual Report 2013 Vumc CCA – Scientific input - 58
58. van der Meij BS, Schoonbeek CP, Smit EF, Muscaritoli M, van Leeuwen PAM, Langius JAE. Pre-cachexia and cachexia at
diagnosis of stage III non-small-cell lung carcinoma: an exploratory study comparing two consensus-based frameworks.
Brit J Nutr 2013; 109: 2231-2239 (4/3.302)
59. van der Spek N, Vos J, Uden-Kraan CF, Breitbart W, Tollenaar RAEM, Cuijpers P, Verdonck-de Leeuw IM. Meaning making
in cancer survivors: a focus group study. PLoS One 2013; 8: (4/3.73)
60. van El CG, Cornel MC, Borry P, Hastings RJ, Fellmann F, Hodgson SV, Howard HC, Cambon-Thomsen A, Knoppers BM,
Meijers-Heijboer H, Scheffer H, Tranebjaerg L, Dondorp W, De Wert GMWR. Whole-genome sequencing in health care
Recommendations of the European Society of Human Genetics. Eur J Hum Genet 2013; 21: 580-584 (4/4.319)
61. van Exel E, Jacobs J, Korswagen LA, Voskuyl AE, Stek ML, Dekker J, Bultink IEM. Depression in systemic lupus
erythematosus, dependent on or independent of severity of disease. Lupus 2013; 22: 1462-1469 (3/2.783)
62. van Gils RF, Bosmans JE, Boot CRL, Rustemeyer T, van Mechelen W, Valk PGM, Anema JR. Economic evaluation of an
integrated care programme for patients with hand dermatitis. Contact Dermatitis 2013; 69: 144-152 (4/2.925)
63. van Litsenburg RRL, Huisman J, Raat H, Kaspers GJL, Gemke RJBJ. Health-related quality of life and utility scores in shortterm survivors of pediatric acute lymphoblastic leukemia. Qual Life Res 2013; 22: 677-681 (4/2.412)
64. van Nieuwenhuizen D, Ambachtsheer N, Heimans JJ, Reijneveld JC, Peerdeman SM, Klein M. Neurocognitive functioning
and health-related quality of life in patients with radiologically suspected meningiomas. J Neuro-Oncol 2013; 113: 433440 (3/3.115)
65. Vermaete NVH, Wolter P, Verhoef GEG, Kollen BJ, Kwakkel G, Schepers L, Gosselink R. Physical Activity and Risk of
Lymphoma: A Meta-Analysis. Cancer Epidem Biomar 2013; 22: 1173-1184 (5/4.559)
66. Wesseling J, Welsing PMJ, Bierma-Zeinstra SMA, Dekker J, Gorter KJ, Kloppenburg M, Roorda LD, Bijlsma JWJ. Impact of
self-reported comorbidity on physical and mental health status in early symptomatic osteoarthritis: the CHECK (Cohort
Hip and Cohort Knee) study. Rheumatology 2013; 52: 180-188 (4/4.212)
67. Zwinkels H, Dorr J, van der Kloet F, Taphoorn MJB, Vecht CJ. Pregnancy in women with gliomas: a case-series and review
of the literature. J Neuro-Oncol 2013; 115: 293-301 (3/3.115)
Scientific publications (books, book chapters, proceedings)
1.
2.
Dirven L, Sizoo EM, Taphoorn MJ. Anaplastic gliomas: End of life care recommendations; in van den Bent MJ, (ed): Grade II
and III loligodendroglioma and oligoastrocytoma. London, Future Science Group. 2013
Taphoorn MJB. Quality of Life in Low-Grade Gliomas; in Duffau H, (ed): Diffuse Low-Grade Gliomas in Adults. Springer.
2013; : 205-217
Professional publications
1.
2.
3.
4.
5.
6.
7.
Boele FW, Hoeben W, Hilverda K, Lenting J, Calis AL, Sizoo EM, Collette EH, Aaronson NK, Taphoorn MJ, Postma TJ,
Reijneveld J, Heimans JJ, Klein M. Kwaliteit van leven bij naasten van patiënten met een primaire hersentumor. Tijdschr
Neuropsych 2013; 8: 97-106
Brand A, Morré SA. Public health genomics - public health goed personalized. TSG 2013; 91: 86-87
Gordijn MS, van Litsenburg RRL, Gemke RJBJ, Bierings MB, Hoogerbrugge PM, van de Ven PM, Rotteveel J, Kaspers GJL.
Hypothalamus-hypofyse-bijnieras-functie in overlevers van acute lymfatische leukemia op de kinderleeftijd en in gezonde
controles. Tijdschr Kindergeneeskd 2013; 81: 7-14
Jansen F, Uden-Kraan CF, Verdonck-de Leeuw IM. Kwaliteit van leven van stomadragers; De Nederlandse
Stomavereniging. 2013
Langius JAE, Leistra E, van Bokhorst-de van der Schueren, Kruizenga HM. Screenen van ondervoeding op de polikliniek
noodzaak. NTVD 2013; 68: 20-22
Overbeeke N, Delsink P, Langius JAE. Verbeteren van de eiwitinname op dag 4: regie loont!. NTVD 2013; 68: 22-24
van der Meij BS, Langius JAE, Spreeuwenberg MD, Slootmaker SM, Paul MA, Smit EF, van Leeuwen PAM. Drinkvoeding
verrijkt met n-3 vetzuren beinvloedt de kwaliteit van leven en functionele status bij patienten met longkanker tijdens
chemoradiotherapie: een RCT. NTVD 2013; 68: S1-S8
Popular publications
1.
2.
Verdonck-de Leeuw IM. Kankerpatiënt ontevreden over informatie nazorg. 2013
Verdonck-de Leeuw IM. Grootschalige studie naar kwaliteit van leven bij hoofd-halskanker. 2013; 5-8
Dissertations
1.
2.
de Bruijn MJ. Speech quality in oral oropharyngeal cancer patients. The development and evaluation of objective speech
assessment methods. 6/10/2013. (Co-)promotores: Verdonck-de Leeuw IM, Leemans CR, Langendijk JA, ten Bosch L (cat
A)
van der Meij BS. The impact of fish oil on clinical parameters and quality of life in patients with cancer. 3/21/2013. (Co-)
promotores: van Leeuwen PAM, van Bokhorst-van der Schueren (cat A)
Appendix Annual Report 2013 Vumc CCA – Scientific input - 59
Appendix 5: Indicators of esteem
Memberships of editorial boards
Associate
Book / journal
Ang, CW
 Nederlands Tijdschrift voor Geneeskunde
 Nederlands Tijdschrift voor Medische Microbiologie
Appelmelk, BJ
 Innate Immunity
Beelen RHJ
 PDI
Bitter, W
 FEMS Microbiology/reviews
 Microbiology Open
Bloemena, E






Boellaard, R
 EJNMMI Physics
Boers, M





Braakhuis, BJM
 Oral Oncology
 Open Pathology Journal
Brakenhoff, RH
 Clincal Cancer Research
 Oral Oncology
 Reports of Practical Oncology and Radiotherapy
Chamuleau, M
 Immunotherapie in de interne geneeskunde
 NTVH
de Bree, R
 European Archives of Otorhinolaryngology
 Oral Oncology
 Nederlands Tijdschrift voor Oncologie
de Gruijl, TD
 Cancer Immunology Research
de Rie, MA




Dekker, J
 International Journal of Behavioral Medicine
Giovannetti, E
 European Journal of Surgical Oncology
 World Journal of Pharmacology
Grunberg, K
 NVVP newsletter and website
Hoekstra, OS
 The Oncologist
Jimenez, CR
 Molecular and Cellular Proteomics
 Journal of Proteomics
 Proteomics
Joenje, H
 Anemia; Cellular Oncology; Familial Cancer; The Open Genomics Journal; Open
Genetics Reviews
Kaspers, GJL




Kluytmans, JAJW
 Plos One
 Infection
World J Gastroenterology
ISRN Gastroenterology
Scandinavian Journal of Gastroenterology
World Journal of Gastrointestinal Oncology
ISRN Gastroenterology
Scandinavian Journal of Gastroenterology
Arthritis and Rheumatism
Letter to the Editor in Rheumatology
Journal for Clinical Epidemiology
Annals of Rheumatic Diseases
Journal of Rheumatology
Dermatology and Therapy
Dermatology
Case Reports in Dermatology
Latin American Journal of Psoriasis and Psoriatic Arthritis
Journal of Oncology
Expert Reviews of Anticancer Therapy
Therapy
Pediatric hematology/oncology and immunopathology
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 60
Associate
Book / journal
 Antimicrobial Resistance and Infection
Lammertsma, AA











Leemans, CR
 Hoofd-hals Journaal (Head and Neck Journal of the NWHHT)
 Nederlands Tijdschrift voor Keel-Neus-oorheelkunde (Netherlands Journal of
Otorhinolaryngology)
 European Archives of Oto-Rhino-Laryngology Head and Neck
 Oral Oncology
 Head and Neck
 Oral Diseases
 Surgical Oncology
 Italian Journal of Maxillofacial Surgery
 Acta Otorrinolaringología Espanola
 Acta Otorhinolaryngoiatrica Italica
 Reports of Practical Oncology and Radiotherapy
 Keel-Neus-Oorheelkunde en hoofd-halschirurgie
 Schwartz's Principles of Surgery
 Oxford Textbook of Oncology
Meijer, CJLM
 Journal of Clinical Virology
 International Journal of Oncology
Meijer, GA
 World Journal of Gastrointestinal Oncology (WJGO)
 Oncology-up-to-date
 Oncology news international
Menko, FH
 Familial Cancer
Middeldorp, JM
 J. Clinical Virology
Mooi, WJ
 Advances in Anatomical Pathology
 Pathology Research International
Morré, SA
 Public Health Genomics
 World Journal of Gastroenterology
 Drugs of Today
Ossenkoppele, GJ
 Duth journal of hematology
Pegtel, M
 Journal of Extracellular Vesicles
 Biology of the Cell
Peters, GJ



















International Journal of Molecular Imaging
Nuklearmedizin
Molecular Imaging and Biology
Journal of Cerebral Blood Flow and Metabolism
European Journal of Nuclear Medicine and Molecular Imaging
Frontiers in Brain Imaging Methods
American Journal of Nuclear Medicine and Molecular Imaging
Clinical and Translational Imaging
OA Medical Physics and Law
OA Molecular Oncology
Journal of Radiology Research and Practice
American Journal of Cancer research
Amino Acids
Annals of Oncology
Applied Scientific Reports
Cancer Chemotherapy and Pharmacology
Cancer Therapy
Chemotherapy Research and Practice
Chinese Journal of Clinicians
Clinical Colorectal Cancer
Current Drug Resistance
European Journal of Cancer
Experimental Hematology and Oncology
Expert Opinion on Drug Metabolism and Toxicology
Gastrointestinal Cancer Reviews
International Journal of Oncology
Journal of Cancer Research and Treatment
Journal of Chemotherapy
Journal of Chinese Clinical Medicine
Journal of Epithelial Biology and Pharmacology
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 61
Associate
Book / journal











Journal of Pharmacology and Toxicology
Journal of Tumor
Journal of Zhejiang University-SCIENCE B (JZUS-B)
Nucleosides, Nucleotides and Nucleic Acids
Oncology Discovery
Pteridines
The Open Lung Cancer Journal
World Journal of Clinical Oncology
World Journal of Gastrointestinal Oncology
World Journal of Gastrointestinal Pharmacology and Therapeutics
World Journal of Pharmacology
Reijneveld, JC
 Neuro-Oncol Practice
Rustemeyer, T
 Contact Dermatitis
 Journal Dermatologie in Beruf und Umwelt
 main reference textbook “Kanerva’s Occupational Skin Diseases”, Springer
Verlag, 2nd edition, 3 parts
 European Surveillance System on Contact Allergens
Savelkoul, PHM
 Editorial Board Clinical Microbiology and Infection (CMI)
Schuurhuis, GJ
 Open Journal of Hematology
 ISRN Hematology
 Dataset Papers in Medicine August 2012
Snijders, PJF
 Journal of Clinical Virology
 International Journal of Oncology
Steenbergen, R
 BMC Cancer
Taphoorn, MJB
 Neuro-oncology
 Neuro-oncology Practice
 Expert Review of Pharmacoeconomics and Outcomes Research
van Beusechem, VW
 Human Gene Therapy
 Genetics Research International
van de Wiel, M
 STAT
van den Elsen, PJ
 Immunogenetics
 Frontiers in Molecular Innate Immunity
van der Waal, I









van Furth, AM
 BMC Infectious Diseases
 "Purple pages" Pediatric Infectious Diseases Journal
van Schaardenburg, D
 Arthrits and Rheumatology
Vandenbroucke-Grauls, CMJE
 Frontiers in Public Health, Section Infectious Diseases
Verdonck-de Leeuw, IM






Cancer
Psycho-Oncology
Folia Phoniatrica Logopedica
Oral Oncology
World Journal of Clinical Oncology
Supportive Care in Cancer
Verweij, CL







The Open Rheumatology Journal
Genes and Immunity
Frontiers in immunology
Frontiers in innate immunology
Arthritis
Recent Patents and Biomarkers
Arthritis Research and Therapy
ACTA StomatologicaCroatica
European Journal of Cancer
Medicina Oral
Minerva Stomatologica
NederlandsTijdschriftvoorGeneeskunde
Oral and Maxillofacial Surgery (OMS)
Oral Health & Preventive Dentistry
Oral Oncology
Revista de Odontologia da Universidade de São Paolo (Journal of Dentistry,
University of São Paolo),
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 62
Associate
Book / journal
Vis, AN




Wesseling, P
 Acta Neuropathologica
 Neuro-Oncology
 Brain Pathology
Windhorst, AD
 Journal of radiolabeled compounds and radiopharmaceuticals
 Nuclear Medicine and Biology
 Current Radiopharmaceuticals
Ylstra, B
 Cellular Ooncology
Zweegman, S
 NTvH
 Leerboek hematologie
Tijdschrift voor Urologie
J Urol
Eur Urol
Int J Cancer
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 63
International functions
Associate
Position / function
Name society / organisation
Abbink, FCH
Member
DCOG protocol Committee CML
DCOG Committee supportive care
Nederlandse Vereniging voor kindergeneeskunde
Nederlandse Vereniging voor Oncologie
Ang, CW
Chair
Committe of "Knowledge sharing" Dutch Society for
Medical Microbiology
Avan, A
Associate memer
American Association for Cancer Research
Bakema, JE
Member
NVVI (nederlandse vereniging van Immunology)
Beelen RHJ
Advisor
Nierstichting Nederland
Coordinator
EuTRiPD 287813
Faculty member
NBIC
Member
Dutch Society of Pattern Recognition and Image
Processing (NVPHBV)
National Committee Proof of Concept Implementation of
Colorectal Cancer Screening, RIVM
service providing (“Dienstverlening”) committee St.
PALGA
SURFnet/academy: Programmacommissie: Seminars De
uitdaging van het delen van medische onderzoeksdata
Dutch Society of Microscopy (NVVM)
Blauwhoff-Bustermolen, S
Member
European Society of Parenteral and Enteral Nutrition
Bleeker, MCG
Member
NVVP
Beliën, JAM
GPA panel
Werkgroep dermatopathologie
Bloemena, E
Boellaard, R
Chairman
Wetenschappelijke Raad PALGA
Landelijke werkgroep leverpathologie
Member
Cie Kwaliteit en Beroepsuitoefening NVVP
Cie Kwaliteit en Capaciteit BVO darmkankerscreening
Cie Kwaliteitseisen Pathologie ihk van het BVO
Darmkankerscreening
Nederlandse Vereniging voor Pathologie
Nederlandse Vereniging voor Immunologie
Nederlandse Vereniging voor Gastroenterologie
Nederlandse Vereniging voor Hepatologie
AACR
European Society of Pathology
ESP Working Group Head and Neck Pathologie
European Salivary gland Society
SFOPOM
Autoimmuun hepatitis werkgroep Nederland
Nederlandse werkgroep Hoofd-Hals Tumoren
Richtlijncie Hepatocellulair Carcinoom
Richtlijncie Hoofd Hals Kanker
Board Member
Netherlands Society Nuclear Medicine
Secretary of educational committee
medical imaging
Netherlands Society Clinical Physics
Chair
EANM Physics Committee
Member and chair of PET
technology committee
EORTC imaging working group
Member, coordinator of PET/CT
accreditation program
EARL Scientific Advisory Board
Advisor
SCM CTN Image Reconstruction WG
Member
HOVON Imaging group
QIBA FDG PET/CT working group
UPICT FDG PET/CT WG
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 64
Associate
Position / function
Name society / organisation
Boers, M
Ambassador
for
rheumatological conditions
non- OMERACT
Co-chairman
EULAR Committee on conduct and reporting of long-term
extension studies in rheumatology
Chair
Trial Steering Committee: ZIPP (zoledronate in prevetion
of Paget) trial. P.I. S Ralston, Edinburgh, UK
Member
EULAR Committee on monitoring of glucocorticoid
therapy in rheumatoid arthritis.
EULAR Committee on guidelines for treatment of
rheumatoid arthritis
OMERACT Task Force on imaging in rheumatoid arthritis
ASAS, international consensus group on guidelines for
outcome measures in ankylosing spondylitis
COMET Steering Group. International initiative to create
measurement core sets for trials across diseases
Vaste Commissie Wetenschap (VCW)
Centrale data safety monitoring board (DSMB)
(Founding) Member
International Academy of Oral Oncology
Member
American Association for Cancer Research
Nederlandse Vereniging voor Oncologie
Nederlandse Vereniging voor Keel-Neus-Oorheelkunde
en Heelkunde van het Hoofd-Halsgebied
Vice-chairman
Vumc CCA Scientific review commitee
Member
NW0
Dutch Society of Cell Biology
Dutch Society of Oncology
Dutch Society of Otolaryngology/head-neck surgery
AACR
Reviewer
AIRC Direzione Scientifica
Bultink, IEM
Member
Nederlandse Vereniging voor Reumatologie
American Society for bone and mineral research
Dutch SLE working party
Interdisciplinary Working Party on Osteoporosis
International Osteoporosis Foundation
Carvalho, B
Member
AACR (American Association for Cancer research)
ISCO (International Society for Cellular Oncology)
PathSoc (Pathological Society of Great Britain & Ireland)
NVGE (Dutch Society of Gastroenterology)
SPGH (Portuguese Society of Human Genetics)
Chamuleau, M
Secretary
HOVON lymphoma working party
HOVON CLL working party
Treasurer
HOVON LLPC working party
Cloos, J
Active member
American Association of Cancer Research
de Bree, R
Board member
Research steering committe NWHHT
Member
Nederlandse Vereniging voor Keel-, Neus- en
Oorheelkunde en Heelkunde van het Hoofd-Halsgebied
Nederlandse Werkgroep Hoofd-HalsTumoren (NWHHT)
Nederlandse Vereniging voor Oncologie
European Head and Neck Society
International Academy of Oral Oncology
American Head and Neck Society
Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum
Chair executive board
Dutch Tumor Immunology Working Party
Active member
American Association for Cancer Research
Lifetime member
Society for Dendritic Cell & Vaccine Science
Member
Society for Immunotherapy of Cancer (SITC)
World Immunotherapy Council (WIC)
Cancer Immunotherapy Consortium
Dutch Association for Immunology (NVVI)
Braakhuis, BJM
Brakenhoff, RH
de Gruijl, TD
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 65
Associate
Position / function
Name society / organisation
Dutch Association for Oncology (NVVO)
Grant Review Board member
Melanoma Research Alliance (MRA)
Committee member
SITC website committee
Scientific Advisory Board member
DCPrime BV
Member
Ned Ver Dermatologie en Venereologie
Eur Acad Dermatology Venereology
Am. Acad Dermatology
Councilor
International Psoriasis Foundation
Board member
Rene Touraine Foundation
President
International Society of Behavioral Medicine
Member
Society of Behavioral Medicine
Academy of Behavioral Medicine Research
Netherlands Institute of Psychologists
Board member
Netherlands Behavioral Medicine Federation
Chair
Netherlands Health Professionals in Rheumatology
(NHPR)
den Haan, JMM
Member
NWO ZONMW VIDI commissie
Dirven, L
Active member
EORTC Quality of Life Group
Member
European Association of Neuro-Oncology
Individual member
EBMT
Individual member
MASCC
Individual member
Nederlandse Vereniging van Seksuologie
Member research sub committee
EBMT Nurses Group
Member working party
EBMT Complications and Quality of Life
Corresponding member
American Head and Neck society
Member of board /representative
for Vumc
Dutch Head Neck society
Member
European Head and Neck Society
Dutch ENT society
Organizing committee
EHNS Make Sense-campaign organizing team The
Netherlands
Fijneman, RJA
Member
American Association for Cancer Research (AACR)
International Society for Cellular Oncology (ISCO)
Dutch Society for Gastroenterology (NVGE)
Franken, S
Member
Nederlandse Vereniging voor Dermatologie en
Venereologie
Gibbs, S
PI within angeogenesis group
NIRM
Member
Nederlandse Vereniging voor experimentele
dermatologie (NVED)
European research group for experimental contact
dermatitis (ERGECD)
Active member
American Association for Cancer Research (AACR)
Member of the Steering Committee
of the EORTC-PAMM
European Organisation for Research and Treatment of
Cancer (EORTC)
Member of the Abstract Selection
Committee
European Pancreatic Club (EPC)
Member
Italian Society for the Study of the Pancreas
Italian Society of Pharmacology
American Pancreas Club Inc
Grant Reviewer
British Lung Foundation
Barts and The London Charity
Hungarian Scientific Research Fund (OTKA)
de Rie, MA
Dekker, J
Eeltink, C
Eerenstein, SEJ
Giovannetti, E
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 66
Associate
Position / function
Name society / organisation
Koningin Wilhelmina Fonds (KWF), Netherlands
Research Foundation Flanders (FWO), Belgium
Grunberg, K
Secretary executive board
NVVP
Scientific advisory board
Dutch Lung Association (longfonds)
Dutch National Tissue Portal
Board member
Workgroup Molecular Diagnostics in Pathology, Dutch
Society for Pathology (WMDP NVVP)
Foundation for Quality Medical Laboratory Diagnostics
(Stichting Kwaliteitsbewaking Medische
Laboratoriumdiagnostiek, SKML) - section Pathology
Chairmen
Committee Quality Control of WMDP-NVVP (QC
committee WMDP NVVP)
External auditor
CCKL/RvA
Member
AACR: American Association for Cancer Research
IASLC: International Association for the Study of Lung
Cancer
NVGE: Dutch Society for Gastroenterology (Nederlandse
Vereniging voor Gastroenterologie)
NVVP Dutch Society for Pathology (Nederlandse
Vereniging voor Pathologie)
VMDG: Society Molecular Diagnostics in Health Care
(Vereniging tot Moleculaire Diagnostiek in de
Gezondheidszorg)
LNVH: National Network of Female Professors (Landelijk
Netwerk Vrouwelijke Hoogleraren)
Member
Society Nuclear Medicine
Eur Assocation of Nuclear Medicine
Quantitative Imaging biomarker alliance
RECIST committee
Ned Veren v Nucl Geneeskunde
EORTC Imaging group
Commissielid
ZON-MW doelmatigheidsonderzoek
ZON-MW translationeel onderzoek
Board member
SNM Centre of Excellence
Lid update commissie namens
NVNG
CBO melanoom richtlijn
CBO KNO richtlijn
Member
International Society of Pediatric Oncology
Member and co-founder
European DIPG Network
Member discipline group Molecular
Research
DCOG
Member
SKION groep “Outreach”
VU Medisch Centrum Outreach Programma afdeling
kinderoncologie
Project Committee World Child Cancer
Medical Trustee
Board World Child Cancer, UK
Co-chair
SIOP Pediatric Oncology in Developing Countries (PODC)
Coordinator
Collaborative Wilms Tumour Africa Project
Twinning Programma met College of Medicine, Blantyre,
Malawi
Jansen, MHA
Member
European DIPG network
Jimenez, CR
Founder and member steering
committee
Netherlands Proteomics Platform
General council member
European Proteomics Association
Member board of directors
Human Proteome Organisation
Chair
Vumc Onderzoek Naar Kinderkanker (VONK)
Ziekte commissie Myeloide Maligniteiten, SKION
Protocol Commissie "Relapsed AML 1999/2001" en
Heideman, DAM
Hoekstra, OS
Hulleman, E
Israels, T
Kaspers, GJL
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 67
Associate
Position / function
Name society / organisation
"Pediatric APL", SKION
Protocol commissie initiele AML, NOPHO-DBH- AML-2012
Taakgroep "shared care", DCOG
"International Outreach Program", SKION
AML Relapse Working Group, International BFM Study
Group
Kors, A
Lammertsma, AA
Programma co-leider
"Quality of Life" van VUmc CCA, VU medisch centrum
Co-voorzitter
IKNL - Werkgroep kindertumoren Amsterdam
Member
Raad van Toezicht SKION
Protocol Commissie ALL-10 en AML2007 (DB-AML01),
SKION
Onderzoekscommissie, SKION
LAD, NVK, NVvO, KNMG, AACR, ASH, EHA, SIOP
Bestuurslid
"Stichting Vumc Kinderstad" 2011 onwards
Bestuurslid, wnd voorzitter per
december 2013
Stichting Ronald MC Donald huis VUmc
Hoofd onderzoeker
DIPG VUmc 01
DIPG PET study
Principal investigator
I-BFM-SG Phase III studies "Relapsed AML 2001/01" and
"Relapsed AML 2010/01"
I-BFM-SG and ITCC study 021 "Bortezomib in childhood
relapsed and refractory ALL"
International coodinator
Phase III study on Pediatric APL (ICC APL 01)
Member
Landelijke werkgroep hemoglobinopathie behandelaren
Werkgroep benigne hematologie van de sectie
kinderoncologie-hematologie van de NVK
Adviescommissie neonatale screening (ANS SIKK) NVK
Werkgroep sikkelcelanemie-netwerk kindergeneeskunde
regio Amsterdam
Protocol commissie aplastische anemie van de
ziektecommissie beenmerkfalen DCOG
IKA stamcelwerkgroep
Landelijke pediatrische werkgroep trombose en stroke
Taakgroep oncogenetica DCOG
Nederlandse vereniging hemofilie behandelaren
European Hematology Association
European Workgroup of the Thalassemia International
Federation
Voorzitter
Protocol Commissie Retinoblastoom van de
ziektecommissie CZS DCOG (Dutch Childhood Oncology
Group)
Member management committee
PET-MRI COST action
Member college van beroep
Stichting Opleiding Klinisch Fysicus
Member scientific advisory board
Center for Integrated Oncology Köln Bonn
Member steering committee
Roche Dutch Imaging Hub
Philips/VUmc collaboration
VUmc/CHDR Clinical Research Unit
Board member
Netherlands Commission on Radiation Dosimetry
Member
International Society of Cerebral Blood Flow and
Metabolism
Society of Nuclear Medicine
European Association of Nuclear Medicine
Society of Nuclear Imaging in Drug Development
Academy for Molecular Imaging
European Society of Molecular Imaging
European Society of Neuropsychopharmacology
Dutch Society of Nuclear Medicine
Dutch Society of Clinical Physics
Dutch Society of Biophysics
New York Academy of Sciences
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 68
Associate
Position / function
Name society / organisation
Langius, JAE
Member
European Society for Clinical Nutrition and Metabolism
(ESPEN)
Dutch Dietetic Association (NVD)
Netherlands Society for Parenteral and Enteral Nutrition
(NESPEN)
Leemans, CR
General board member
Dutch Head and Neck Oncology Cooperative Group
(NWHHT)
Chair subcommittee Surgery
Head and Neck Cancer Cooperative Group of the
European Organization for Research and Treatment of
Cancer (EORTC)
Secretary
Working Party Head and Neck Surgery of the Netherlands
Society for Otorhinolaryungology and Cervico-Facial
Surgery
Founding board member
European Head and Neck Society
Founding fellow
International Academy of Oral Oncology
Member
Netherlands Society for Otorhinolaryngology and
Cervico-Facial Surgery
Netherlands Society of Oncology
American Head and Neck Society
American Academy of Otolaryngology-Head and Neck
Surgery
Concilium Oto-rhino-laryngologicum in the Netherlands
Britisch Association of Head and Neck Oncologists
European Rhinological Society
Collegium Oto-rhino-laryngologicum Amicitiae Sacrum
(CORLAS)
European Salivary Gland Society (ESGS)
Spanish Society of Otorhinolaryngology-Head and Neck
Surgery (Sociedad Espanola de Otorrinolaringologia y
Pathologia Cérvico-Facial; SEORL-PCF)
Lems, WF
Member
Scientific Board EULAR, 2013-2015
Mebius, R
Incoming president/ president
Dutch society for immunology
Meijer, CJLM
Advisory member
Commissie Baamoederhalskanker (Gezondheidsraad)
Member
Signaleringscie kanker KWF/NKB
Commissie ombudsman Vumc
Ned. Vereniging voor pathologie
Ned. Vereniging voor oncologie
Pathological Society of Great Britain and Ireland
British Division of the International Academy of
Pathology
European Association of Haematopathology
Ned. Vereniging voor Rheumatologie
Member
National Committee for Implementation of Colorectal
Cancer Screening, RIVM
Member of the Scientific Board and
Chairman of the Committee for
Translational Research
Dutch Cancer Society (KWF)
Member Scientific Advisory
Committee Colorectal Cancer
Maag, Lever, Darmstichting
Member Scientific Advisory Board
Etriks
Officer
International EBV Association
Member
European Society for Clinical Virology
Netherlands Society for Immunology
Netherlands Society for Medical MicrobiologyMember
Netherlands Society for Biochemistry and Molecular
Biology
Member
Nederlandse Vereniging voor Pathologie
Meijer, GA
Middeldorp, JM
Mooi, WJ
Nederlandse Vereniging voor Oncologie
Tumorfocusgroep melanoom
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 69
Associate
Position / function
Name society / organisation
Commissie herziening landelijke richtlijn melanoom
Morré, SA
Member, scientific advisory
committee
Stichting KIKA
Honorary member
British Society for Dermatopathology
Member
Dutch Society for Biochemistry and Molecular Biology
Royal Dutch Society for Chemistry
Dutch Biotechnological Society
Royal Dutch Society for Medical Microbiology
European Foundation of Immunogenetics
Mostert, S
Member
Siop PODC Abandonment of Treatment Working Group
Ossenkoppele, GJ
Board member
Dutch Society of Hematology
HOVON
European leukemia Net Foundation
European Hematology Association
Chair AML Working party
European leukemia Net
Member edicational Committee
European Hematology Association
Chair review Board Conten learning
Center
European Hematology Association
Chair AML Scientific Working Party
European Hematology Association
Member
European Organization for Research and treatment of
Cancer
Peters, GJ
EORTC General Assembly
EORTC Pharmacology and Molecular Mechanisms Group
EORTC-Translational Research Advisory Committee
(TRAC)
American Association for Cancer Research
Review Committee UICC for Translational Cancer
Research Funds
(TRCF) and ACSBI (1998-)
Postma, TJ
Reijneveld, JC
Chair (2009-)
EORTC Drug Discovery Committee NCI compounds task
force
Secretary/treasurer
Purine and Pyrimidine Society (PPS)
Advisory boards
Steering Committee IMBRAIN, an EU funded program for
Outermost Regions
of the EU, Canary Islands, Spain (2012-)
Kucera Pharmaceuticals, Winston-Salem, NC, USA
Salzburg Therapeutics, Winston-Salem, NC, USA
Taiho Pharmaceuticals, Tsukuba, Japan
Lid Expert panel Medisch
Onderzoek; Med4 (“Cancer Therapy
and biology”).
Fonds Wetenschappelijk Onderzoek (FWO) Vlaanderen
(2013-)
Panel member La Marato de TV3
call on Cancer (2013-)
Agency for health Quality and Assessment of Catalonia
(Cahta Research)
Member steering commitee
PERINOMS outcome measure study
Member
SNO
EANO
LWNO
Member
Society for Neuro-oncology (SNO)
European Association for Neuro-Oncology (EANO)
Chair
Dutch Society for Neuro-Oncology (LWNO)
Member Steering Committee
EORTC Brain Tumour Group
Member Executive Committee
EORTC Quality of Life Group
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 70
Associate
Position / function
Name society / organisation
Rinkel RNPM
Member
European Laryngological Society
Rozendaal, L
Counsellor nationwide retrieval
research data
Stichting Palga
Rustemeyer, T
Member
Working party Allergologic Occupational Disorders
Dutch Association of Dermatology and Venereology
Expert group of Allergology and Contact Dermatitis of
the Dutch Association of Dermatology and Venereology
European Surveillance System on Contact Allergens
Guideline “Lichen sclerosus” of the Dutch Association of
Dermatology and Venereology
Board member
European Environmental and Contact Dermatitis
Research Group
European Surveillance System on Contact Allergens
European Prevention of Occupational Skin Diseases
Continuum Dermatologica
Scientific advisor and member
CESES program of the Department of Public Health
Chair person
PMS cosmetica
Hallmark of Skin Foundation
Guideline "Atopic Dermatitis of the Dutch Association of
Dermatology and Venerology
Member
Nederlands Vereniging voor Medische Microbiologie
Member Nederlands Vereniging voor Microbiologie
(NvvM)
European Society for Clinical Microbiology and Infectious
Diseases (ESCMID)
Member American Society for Microbiology (ASM),
European Society of Clinical Virology (ESCV)
Chairman
ESCMID European Study Group on Molecular Diagnostics
(ESGMD),
Sectie Microbiële Typeringen, NvvM
Member
Nederlandse Vereniging voor Immunologie
American Association for Cancer Research
Eur Exp Contact Dermatitis Res Group
Eur Environm and Industr Cont Derm Group
Bestuurslid
Stichting Milieu- en Arbeidsdermatologie
Alg directeur
A-Skin BV, Amsterdam (Vumc spin-off)
Schuurhuis, GJ
Chair
AML-MRD working party
Sminia, S
Councillor
International Association of Radiation Research
Board member
Dutch Commission on Radiation Dosimetry (NCS)
Member
European Radiation Research Society (ERRS)
Neuro-Oncology group Integral Cancer Center
Netherlands
European Society for Therapeutic Radiology and
Oncology (ESTRO)
European Association of Neuro Oncology (EANO)
International Association of Radiopathology (IAR)
Dutch Society for Radiotherapy and Oncology (NVRO)
Dutch Society for Radiobiology (NVRB)
Member evaluation committee
Swiss Cancer League
Yorkshire Cancer Research Foundation
Member evaluation committee
Nederlandse Vereniging voor Oncologie / Rene Vogels
Stichting
Smit, L
Active Member
AACR
Snijders, PJF
Member
Nederlandse Vereniging voor Pathology
Member executive board
International Papillomavirus Society
Member
AACR: American Association for Cancer Research
ASM: American Society Microbiology
Member scientific board
IPV:International Papillomavirus Society
Savelkoul, PHM
Scheper, RJ
Steenbergen, R
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 71
Associate
Position / function
Name society / organisation
Taphoorn, MJB
Member
Cancer Research UK Clinical Trials Awards and Advisory
Committee
Samantha Dickson Brain Tumour Trust Grant Review and
Monitoring Committee
The National Brain Tumor Society Steering Committee on
Clinical Trials Endpoints
Member scientific advisory board
Stichting STOPhersentumoren
Member Commissie GBBS
Gezondheidsraad
Board member
Simonsfonds
Unger, W
Member
NVVI
CWO
van Asseldonk, D
Member executive board
Young initiative on Crohns and Colitis
Pharmacology committee NVMDL
van Beusechem, VW
Board member (treasurer)
Netherlands Society of Gene and Cell Therapy
Chair, science committee
Netherlands Society of Gene and Cell Therapy
Member
American Society of Gene and Cell Therapy
American Association for Cancer Research
RNAi Global Initiative
van den Elsen, PJ
Member
Dutch Society for Pathology
Dutch Society for Immunology
Van der Horst-Bruinsma, IE
Executive Board member
ASAS (Assessment of SpondyloArthritis International
Society, worldwide organisation of researchers in
Ankylosing Spondylitis)
(Vice-) chair
mDagelijks Bestuur Stafconvent VUmc
Chair
NVR-werkgroep landelijke richtlijn Spondyloartrtritis
Board member
GENetica Research (GENRA) Amsterdam
Member
Managementteam Reumatologie
Stuurgroep ziekenhuisverplaatste zorg VUmc
Stuurgroep verwijzers VUmc
Commissie wetenschappelijke stages VICI
Werkgroepen zorgpad ontwikkeling ziekte van Bechterew
en artritis psoriatica VUmc-Reade/JBI
Committee member
National working group imaging in Rheumatology (IRON)
(Rheumatology Ultrasound)
Member
European working group of risk factors for rheumatoid
arthritis
Van der Waal, I
Member of Scientific Committee
STOMA
van Die, I
Member editorial board
Glycoconjugate Journal
van Dulmen-den Broeder, E
Executive Board member
Dutch Childhood Oncology Group-LATER Taskgroup
Member and work group leader
within Female Fertility Guideline
International Guideline Harmonisation Group
Member
Advisory commitee Royal Tropical Institute
NVK wetenschapscommissie
Interne Auditcommissie (IAC)
Voorzitter
Commissie wetenschappelijk onderzoek Vumc
Kindergeneeskunde
Secretary
Dutch Gastric Cancer Group (DGCG)
Member
Dutch clinical guideline on Esophageal cancer
Scientific Committee Dutch Upper GI Audit (DUCA)
Werkgroep Erfelijke Maagtumoren
European Union Network of Excellence on Gastric cancer.
Scientific Committee Parelsnoer Erfelijke darmkanker
Member scientific committee
International Immunology meeting Milan
Board member
Dutch Society of Immunology (NVVI)
te Riel, H
Van der Laken, J
van Furth, AM
van Grieken, NCT
van Kooyk, Y
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 72
Associate
van Montfrans, C
Position / function
Name society / organisation
Scientific board member
KWF
Vice-president
NVDV
Board member
EADV
Member
Scientific programming committee EADV 2014
WIN-O
President
PR committee NVDV
van Sörnsen de Koste, JR
Member councel board
Trainee programe of VU medical students
Van Vliet SJ
Participating investigator
Consortium for Functional Glycomics
Member
Club Francophone des Cellules dendritiques (CFCD,
French Dendritic Cell Society)
Ducth Society for Immunology (NVVI)
Dutch Society for Glycobiology
Chairman
European DIPG network
DCOG protocol committee DIPG
Member
DCOG protocol Committee Medulloblastoom
DCOG protocol Committee High Grade Glioma
DCOG Committee Research new medicines
AACR
Society for Neuro-Oncology
Vandenbroucke-Grauls, CMJE
Fellow
Royal College of Physicians (UK)
Veening, M
Member
Adviescommissie Neonatale Screening (ANS SIKK) NVK
Landelijke werkgroep hemoglobinopathie behandelaren
Landelijke pediatrische werkgroep trombose en stroke
Nederlandse Vereniging voor Hemofilie behandelaren
Nederlandse Vereniging voor kindergeneeskunde
Werkgroep benigne hematologie van de sectie
kinderoncologie-hematologie van NVK
DCOG protocol Committee ALL-11
DCOG committee LATER
DCOG Euronet-PHL-C2 committee (Hodgkin)
Dutch network fertility preservation
Verdonck-de Leeuw, IM
Member Executive Committee
EORTC Quality of Life Group
Chair
MASCC Study Group on Cancer Survivorship and
Rehabilitation
CCA and EMGO Research Program Quality of Life in
Cancer
Member Advisory Board
NIVEL patient panel Living with Cancer
Program leader
V-ICI VUMC, program 3: Disease profiling
Member advisory committee
BioScience Biomarker summit symposium
Member of the abstract selection
committee and session chairman
European Workshop for Rheumatology Research
Member of the organizing
committee and session chair
Annual Dutch Arthritis Symposium
Member
Dutch Society for Rheumatology (NVR)
Dutch Society for Immunology (NVVI)
Dutch Inflammation Network (NIN)
International Society for Translational Medicine (ISTM)
European Association for Predictie and Personalised
Medicine (EPMA)
Vis, AN
Member
EAU
ERUS
NVU
NVEC
Waisfisz, Q
Member
Scientific Research Committee CWO, VUmc CCA
Wesseling, P
Member
International Society of Neuropathology (ISN)
American Association of Neuropathologists (AANP)
European Confederation of Neuropathol. Societies
van Vuurden, DG
Verweij, CL
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 73
Associate
Position / function
Name society / organisation
(EURO-CNS)
Society for Neuro-Oncology (SNO)
European Association of Neuro-Oncology (EANO)
EORTC Brain Tumor Group
Nederlandse Vereniging voor Pathologie (NVVP)
Nederlandsse Vereniging voor Neuropathologie (NVvNP)
Landelijke Werkgroep voor Neuro-Oncologie (LWNO)
Central reviewing pathologist
EORTC CATNON Study
president
Society of Radiopharmaceutical Sciences
member
European Association Nuclear Medicine, Drug
Development committee
member of the board
Nederlandse Klinische Radiochemici Vereniging
Wintzen, M
Member
Ned Ver Dermatol Venerol
Ned Ver Allergologie
Ned Ver Psychodermaology
Consilium Dermatologicum
Plenaire visitatiecommissie dermatologie
Ylstra, B
Chair
International Society of Cellular Oncology (ISCO)
Member
American Association of Cancer Research (AACR)
Nederlandse Vereniging voor Oncologie (NVvO)
3-year member apointment FWO
Expertpanalist Med4: Cancer
Research
Research Foundation Flanders (FWO)
Chair
HOVON Imaging working group
Member
HOVON Lymphoma group
Vice chairman
HOVON Myeloma Working Group
Member executive board
European Myeloma Network
Member
Cie Klinische Studies KWF
The Myeloproliferative Neoplasms Quality of Life (MPNQOL) International Study Group
American Society of Hematology
European Hematology Association
Commissie Organisatie en Financiering Nederlandse
vereniging voor Hematologie
Windhorst, AD
Zijlstra, JM
Zweegman, S
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 74
Invited lectures
Associate
Title / topic lecture
Meeting
URL meeting /
program
Appelmelk, BJ
COST and the mycobacterial alphaglucan capsule
COST1003 Progress meeting, IT,
Aci Trezza, 10-11-2013
www.costbm1003.info/
Mycobacterium tuberculosis
Invited symposium at BOKU, AT,
Vienna, 26-4-2013
Glycolipids and host-pathogen
interaction
COST1-bm1003 Training School,
SP, Madrid, 29/1-1/2-2013
www.costbm1003.info/activitie
s.html
BCG glycolipid mutants as vaccines
TBVI-NEW TBVAC, CH, les
Diablorets, 29/1-1/2-2013
www.tbvi.eu/newsagenda/events.html
Baart, JA
Non-neoplastic salivary gland
disorders: diagnosis and
management
European Meeting on Oral
Diseases, NL, Amsterdam, 4/6-92013
Bakema, JE
Pathogen recognizing receptors
and antibody binding Fc receptors
synergize their inflammatory
responses
15th International Congress of
Immunology (based on abstract
submission) , IT, Milaan, 22/278-2013
Beelen RHJ
Anti-inflammatory drugs
Summerschool EuTRiPD, AT,
Vienna, 19-6-2013
Overview EuTRiPD
Winterschool EuTRiPD, NL,
Maastricht, 15-10-2013
Bridging the generation gap in PD
research
EuRoPD, NL, Maastricht, 13-102013
Overview EuTRiPD
PD initiatives, NL, Hengelo, 20-92013
Beliën, JAM
Translational Research IT (TraIT):
TraIT and OpenClinica: partners in
translational research
OpenClinica Global conference
meeting 2013, USA, Boston, 216-2013
community.openclini
ca.com/conference
Bitter, W
The type VII secretion systems of
pathogenic mycobacteria: how do
they work and what is their role in
virulence?
LSTHM seminar, GB, Londen, 311-2013
www.lshtm.ac.GB/ne
wsevents/events/201
3/01/the-type-viisecretion-systems-ofpathogenicmycobacteria-howdo-they-work-andwhat-is-their-role-invirulence
Bloemena, E
Cytology of salivary gland tumors
NVML Vakbeurs, NL, The Hague,
26-3-2013
www.nvml.nl/Opleidi
ng__registratie/47/3
71/NVMLNascholing,_Congres
sen__Symposia.html
Basale Oncologie
NMT congres, NL, Zeist, 14-62013
www.nmtjaarcongres.
nl/2013/
Cytology and histopathology of
neoplastic and non-neoplastic
salivary gland lesions
Eur Meeting on Oral Diseases, NL
, Amsterdam, 5-9-2013
www.benns.nl/agend
a/274/europeanmeeting-on-oraldiseases-diagnosisand-management
Kwaliteitscriteria in het kader van
het BVO Darmkankerscreening
WHT thema dag, NL, Den Dolder,
5-11-2013
Cytology and histopathology of
neoplastic and non-neoplastic
salivary gland lesions
European Meeting on Oral
Diseases, NL, Amsterdam, 4/6-92013
Cytology of salivary gland tumors
NVML Vakbeurs, NL, Den Haag,
26-3-2013
NMT congres
Basale Oncologie, NL, Zeist, 14-62013
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 75
Associate
Boellaard, R
Title / topic lecture
Meeting
WHT themadag
Kwaliteitscriteria Pathologie in
het kader van het BVO
Darmkankerscreening, NL, Den
Dolder, 5-11-2013
Wat doet een patholoog?
Opleiding tot oncologisch, NL,
Amsterdam, 12-112013verpleegkundige
Histology of head and neck
squamous cell carcinoma
OOA Course, NL, Amsterdam, 311-2013
Cytology of salivary gland tumors
AIOS course, AMC, NL,
Amsterdam, 29-1-2013
Wat is kanker?
PAOT cursus voor tandartsen,
ACTA, NL, Amsterdam, 5-4-2013
PET/MR: possible clinical
applications, opportunities and
challenges
Dag van de Biofysica, NL,
Amsterdam, 22-11-2013
Het belang van standaardisatie van
PET(CT) voor Multi-center studies
DLCRG (Dutch Lung Cancer
Research Group), NL, Amersfoort,
15-3-2013
Impact of Partial Volume Effects on
Image Quantification and Review of
PVE Correction Methods
Precongres symposium
"Quantitative Imaging and
Dosimetry: Steps towards
Personalised Nuclear Medicine
Treatments", FR, Lyon, 19-102013
URL meeting /
program
www.biopm.nl
www.eanm.org
The EARL FDG-PET/CT
EARL session at EANM
Accreditation Programme &
(Eur.Association of Nuclear
Guideline Developments: Results of Medicine, FR, Lyon, 20-10-2013
First 55 Successfully Accredited
Sites and Future Perspectives
www.eanm.org
CTE 4: Reconstructions: TrueX
+TOF, PSF, OSEM
CTE session at EANM
(Eur.Association of Nuclear
Medicine) , FR, Lyon, 20-10-2013
www.eanm.org
Optimization of PET/CT acquisition
protocols
Eur.Fed.Of Med.Physics
summerschool, CZ, Prague, 7-42013
www.efomp.org
Standardization of 18F-FDG PET/CT Eur.Fed.Of Med.Physics
for treatment response
summerschool, CZ, Prague, 7-5assessments
2013
www.efomp.org
Correlative imaging: methods and
software for PET/CT image fusion
with other imaging modalities
Eur.Fed.Of Med.Physics
summerschool, CZ, Prague, 7-62013
www.efomp.org
What could nuclear medicine offer
for dose painting?
ESTRO-EANM-ICIS course"Molecular imaging and dose
painting in Radiation, CH,
Geneva, 19-4-2013
Symposium: PET quantification
ESTRO-FORUM, CH, Geneva, 204-2013
PET kwantificatie; er is meer dan
SUV alleen
Fontys themadag:Kwantificering
binnen de nucleaire
geneeskunde, NL, Eindhoven, 1111-2-13
“Opportunities and challenges of
PET/MR brain imaging
Micro Symposium on Multimodal
Imaging, NL, Amsterdam, 1-102013
PET/MR: methodologische
aspecten en eerste resultaten
Ned.Ver, Klinische Fysica,
jaarcongres, NL, De Lutte, 10-32013
PET/MR evaluation and
standardisation3
PET/MR Workshop Tuebingen,
DE, Tuebingen, 4-10-201
www.nvkf.nl
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 76
Associate
Title / topic lecture
Meeting
Boers, M
Core sets of measures for clinical
trials: concepts and structures
Meeting on Psoriasis Outcome
Measures.,USA, Boston
Core sets of measures for clinical
trials: concepts and structures
Meeting on core set development
for GB’s InBank, US, Bristol
90 minute workshop on scientific
graphs
EULAR annual conference, SP,
Madrid
Sing literature to solve clinical
problems
EULAR annual conferen ce, SP,
Madrid
COBRA therapy in RA: two decades
of experience
5th International Conference on
Neuroendocrine Immunology in
Rheumatic Diseases (NEIRD) , IT,
Genova
Brakenhoff, RH
URL meeting /
program
6th International Symposium on
Metastasis in Head and Neck
Cancer, DE, Marburg, 24/27-12013
International Conference on
Innovative Approaches in Head
and Neck Oncology, SP,
Barcelona, 7/9-2-2013
25th Annual Fanconi Anemia
Research Fund Scientific
Symposium, USA, Houston,
Texas, 24/27-10-2013
European Head and Neck Course,
NL, Amsterdam, 18/20-9-2013
FA-familiedag, NL, Leersum, 289-2013
EUROGIN 2013, IT, Florence, 3/711-2013
Bultink, IEM
Fractures in systemic lupus
erythematosus
European Calcified Tissue Society
2013, 40th annual congress, PT,
Lisbon, 18-5-2013
www.ectscongress.or
g
Sporten met reuma
Symposium Aangepast
(top)sporten: wetenschap en de
sportpraktijk, NL, Amsterdam,
11-10-2013
www.reade.nl/casa.sy
mposium
Fracturen bij systemische lupus
erythematosus
Interdisciplinary Working party
on Osteoporosis, NL, Zwolle
30-11-2013
www.stichtingiwo.nl
Carvalho, B
Molecular markers for early
detection of colorectal cancer in
stool
3rd International Symposium on
Translational Medicine, BRl,
Barretos, 29-08-2013
Chamuleau, M
DLBCL
NHC, NL, Papendal, 23-1-2014
DLBCL and Burkitt
Lyfe symposium, NL, Amsterdam,
10-4-2013
Assessment of response after
induction chemotherapy in head
and neck squamous cell carcinoma
European Cancer Congress, NL,
Amsterdam, 28-9-2013
FDG-PET in head and neck cancer
Wonnie Goedhart Symposium,
SR, Paramaribo, 10-10-2013
Welk klinisch follow-up schema na
behandeling hoofd-halstumoren?
Scientific meeting VWHHT, BE,
Brugge, 27-4-2013
ECT versus other local treatments
of head and neck cancer
Electrochemotherapy. 2nd
International Users’ Meeting, IT
Bologna, 1-3-2013
Immune biomarkers in prostate
Society for Translational
de Bree, R
de Gruijl, TD
www.vumc.nl/afdelin
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 77
Associate
URL meeting /
program
Title / topic lecture
Meeting
cancer
Oncology Annual Meeting 2013,
NL, Amsterdam,
1-10-2013
genthemas/88610/7694
662/STO_Meeting_VU
mc_CCA_1_oct_1.pdf
Chemoimmunotherapy approaches
Cancer Vaccine Institute 1st Intl
Symposium on Immunotherapy,
GB, London, 11-10-2013
www.cvi.org.GB/spea
ker/dr-tanja-degruijl/
de Lange, J
Synthetic lethality between DDX11
and ESCO2
Fourth Informal Meeting on
Cohesin Biology and the
Cohesinopathies, 12-07-2013
de Rie, MA
New developments in the nonsurgical treatment of skin cancer
Untitled, CH, University of Bern,
29-1-2013
New developments in the nonsurgical treatment of skin cancer
Charles Rodolphe Brupbacher
Symposium, CH, Zurich, 30-12013
Th17: the bridge between
infections and psoriasis
Third Surinam / Dutch
Conference on Tropical
Dermatology, SR, Paramaribo
14-4-2013
Th 17 and IL23
Eilanddagen, NL,
Schiermonnikoog, 23-6-2013
Th17: the bridge between
infections and psoriasis
Bruggedagen, NL, Santpoort,
29-8-2013
Overview of pathways in the
treatment of psoriasis
EADV Novartis satelite
symposium, TR, Istanbul, 3-102013
Screening for psychological
distress: is screening the effective
solution?
Society of Behavioral Medicine.
USA, San Fransico, 1-3-2013
Psychological distress in patients
with cancer: is screening the
effective solution?
International Psycho-Oncology
Society, NL, Rotterdam, 1-102013
Psychological distress in patients
with cancer: is screening the
effective solution?
Psychological distress in patients
with cancer: is screening the
effective solution? CL, Santiago,
1-11-2013
Up-regulation of E2F3 target genes
is a common denominator in
primary Rbs which overall display a
highly variable genome instability
Third International Rb meeting,
USA, Monterey, 07-10-2013
Up-regulation of E2F3 target genes
is a common denominator in
primary Rbs which overall display a
highly variable genome instability
Third International Rb meeting
(Monterey, CA, United States) ,
USA, California, 7-10-2013
High-resolution SNP array profiling
identifies variability in
retinoblastoma genome stability
International Society for Genetic
Eye Diseases & Retinoblastoma
(ISGEDR) meeting (Ghent,
Belgium) , BE, Ghent, 24-8-2013
Characterization of
retinoblastomas without RB1
mutations: genomic, gene
expression and clinical studies
NOG 2013 (Groningen,
Netherlands) , NL, Groningen, 213-2013
Dekker, J
Dorsman, JC
Eerenstein, SEJ
Critical weightloss before and
4th International congress Head
during (adjuvant) radiotherapy:
Neck Oncology (ICHNO) , SP,
major prognostic factors for overall Barcelona, 7-2-2013
adn disease specific survival in
head and neck cancer patients
Voice rehabilitation in
laryngectomized patients
6th European Head and Neck
course, NL, Amsterdam, 20-92013
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 78
Associate
Title / topic lecture
Meeting
Panel salivary glands
6th European Head and Neck
course, NL, Amsterdam, 19-92013
Panel larynx
6th European Head and Neck
course, NL, Amsterdam, 20-92013
Critical weight loss during
(chemo)radiotherapy has a
significant impact on quality of life
and disease specific survival in
head and neck cancer patients
4th Trends in Head and Neck
Oncology (THNO) , HR,
Dubrovnik, 7-11-2013
Faramarz, A
Role of ESCO1 and ESCO2 in:
Establishment of sister chromatid
cohesion, and DNA repair
Fourth Informal Meeting on
Cohesin Biology and the
Cohesinopathies, 12-07-2013
Fijneman, RJA
Translational research
Life science e-infrastructure, IT,
NL, Amsterdam, 10-10-2013
Translational research
CTMM annual meeting, IT, NL,
Utrecht, 9-12-2013
Forouzanfar, T
Oral cancer and the role of the
dentist
QP Dental Education, NL,
Amsterdam, 2-2-2013
Gibbs, S
Skin models and DC migration
Eurotox, CH, Interlaken, 1/4-092013
Giovannetti, E
Prognostic and biological role of
MiR-101, MiR-155 and MiR-21 in
Pancreatic Intraductal Papillary
Mucinous Neoplasms
American Pancreas Club Meeting
2013. USA, Orlando, 17-05-2013
High-throughput microRNA
(miRNAs) arrays unravel the
prognostic role of miR-211 in
pancreatic cancer, and functional
analyses suggest its role in the
modulation of gemcitabine activity
and invasive behaviour
Joint British Association for
Cancer Research (BACR) European Organization for
Research and Treatment of
Cancer (EORTC) Meeting, GB,
Cardiff, 25-01-2013
Invited lecture “Genetic factors
determining therapy response”
45th Annual Meeting of the of
the European Pancreatic Club
(EPC-2013), CH
Zurich, 26-06-2013
Invited lecture “Pharmacogenetics
of non-small-cell-lung cancer
Congress “Lung cancer”, IT,
Parma, 20-09-2013
Comprehensive arrays for
expression profiling identify key
microRNA to distinguish short and
long survivors among resected
pancreatic cancers patients
ESMO-ECCO 2013, NL,
Amsterdam, 01-10-2013
CYB5A emerges as a novel
prognostic factor in pancreatic
cancer, and is involved in the
modulation of autophagy and
oncogenic phenotypes
Erasmus University Medical
Center, Rotterdam, The
Netherlands, Department of
Gastroenterology & Hepatology
Meetings, NL, Rotterdam, 21-102013
Tissue procurement for molecular
diagnostics in lung cancer
CCLO Meeting, CA, Vancouver
BC, 8/10-2-2013
Diagnostic yield of bronchoscopy
School of respirology, NL,
Amsterdam, 10-10-2013
Grunberg, K
Heideman, DAM
Title: Molecular Tools for Pathology 20th International Molecular
Diagnostics: Requirements in
Medicine Tri-Conference. USA
Terms of Turnaround Time,
San Francisco, 2-2013
URL meeting /
program
www.eurotox2013.co
m/fileadmin/user_up
load/programme/45
24EUROTOX_Program
_Booklet_2013_LR.pd
f
www.tfri.ca./home.as
p
-
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 79
Associate
Title / topic lecture
Meeting
URL meeting /
program
Specimens, and Quality Assurance.
Diagnostics and Cancer Channel:
Cancer Molecular Markers –
Advancing Personalized Medicine.
Session: FFPE samples
Title: The Use of Molecular HPV
testing in Cervical Cancer
Screening Programs and The
Validation of The Aptima HPV Test
according to the NVVP/WMDP
Guidelines
Post Summer Masterclass on
Diagnostics, , NL, Utrecht, 18-92013
Title: Self-sampling for nonattendees of screening in the
Netherlans. Session: SS7: New
trends of vaginal self-sampling
Eurogin. IT
Florence, 11-2013
Title: Cervical HPV screening:
medical professionalsampling and
self-sampling – High income
countries. Session: SS17: Screening
Eurogin. IT, Florence, 11-2013
Title: Molecular Tools for Pathology 20th International Molecular
Diagnostics: Requirements in
Medicine Tri-Conference. USA,
Terms of Turnaround Time,
San Francisco, 2-2013
Specimens, and Quality Assurance.
Diagnostics and Cancer Channel:
Cancer Molecular Markers –
Advancing Personalized Medicine.
Session: FFPE samples
Hoekstra, OS
Huisman, M
-
Title: The Use of Molecular HPV
testing in Cervical Cancer
Screening Programs and The
Validation of The Aptima HPV Test
according to the NVVP/WMDP
Guidelines
Post Summer Masterclass on
Diagnostics, NL, Utrecht, 18-92013
Title: Self-sampling for nonattendees of screening in the
Netherlans. Session: SS7: New
trends of vaginal self-sampling
Eurogin. IT
Florence, 11-2013
Title: Cervical HPV screening:
medical professionalsampling and
self-sampling – High income
countries. Session: SS17: Screening
Eurogin. IT, Florence, 11-2013
Oxford debate on PET scanning
ECCO, NL, Amsterdam, 29-92013
on the contribution of PET
technology to drug development
and clinical practice
state of the art in diffuse intrinsic www.knaw.nl/en/new
pontine glioma, NL, Amsterdam, s/calendar/akademie
8-3-2013
-colloquium-state-ofthe-art-in-diffuse-en
Image derived input functions
World molecular imaging
conference , USA, Savannah, 1809-2013
Israels, T
ECCO 2013 website
www.wmis.org/meeti
ngs/
Meeting steering committee
Collaborative Wilms Tumour
Africa Project; 3 dagen, MW,
Blantyre, 1-3-2013
SIOP Annual scientific congress
Hong Kong. Coordinator
Programma SIOP Pediatric
Oncology in Developing
Countries (PODC), HK, China, 19-2013
Jager, DHJ
Tanderosie
Tandheelkunde op to date 2013,
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 80
Associate
Title / topic lecture
Meeting
URL meeting /
program
NL, Maastricht, 12/14-9-2013
Comfortable Solutions in Times of
demographic Changes
3M ESPE Espertise™ symposium,
NL, 21/22-11-2013
Jansen, MHA
DIPG: Finding the right target in
the right patient
Tom Voute Award, NL, Utrecht,
6-2-2013
Jimenez, CR
Cancer Proteomics
7th European Summerschool
Advanced proteomics , IT,
Brixen, 9-8-2013
Proteomics of Exosomes Secreted
by Cancer Cell lines and Primary
Cells Reveals Oncogenic Signaling
and Biomarker Potential
International Society of
Extracllular Vesicles (ISEV)
meeting, USA, Boston, 18-4-2013
Label-free proteomics for
biomarker discovery and validation
in proximal fluids
Annual meeting Human
Proteome Organisation HUPO
2013, JP, Yokohama, 9-2013
Cancer Proteomics: Novel
biomarkers for colon cancer
screening and BRCA1 deficient
breast cancer
Netherlands Proteomics Center
10-year anniversary meeting, NL,
Utrecht, 11-2-2013
From peptidomics to proteomics, a
personal view of 25 years of labelfree mass spectrometry
PAC Imagine symposium, NL,
Amsterdam, 7-3-2013
Karagozoglu, KH
Management of oral cancer
European Meeting on Oral
Diseases, NL, Amsterdam, 4/6-92013
Kaspers, GJL
Hodgkin lymphoma
4th Workshop on Pediatric
Oncology, KE, Eldoret, 15-1-2013
Oncologic emergencies
4th Workshop on Pediatric
Oncology, KE, Eldoret, 15-1-2013
Abdominal mass
4th Workshop on Pediatric
Oncology, KE, Eldoret, 16-1-2013
Shared care
SKION dagen, NL, Utrecht , 7-22013
Myeloide Maligniteiten
SKION dagen, NL, Utrecht, 7-22013
Outreach
SKION dagen, NL, Utrecht , 8-22013
Master
Masterclass Kindergeneeskunde,
NL, Amsterdam, 28-2-2013
Pediatric APL
St. Jude VIVA preforum meeting,
SG, Singapore, 6-3-2013
Progress in Diagnosis and
Treatment of Pediatric AML
St. Jude-VIVA Forum, SG,
Singapore, 8-3-2013
ATRA, Arsenic and Emergency
St. Jude-VIVA Forum expert
Managemen of acute promyelocytic meetings, SG, Singapore, 8-3leGBemia in developing countries
2013
Progress on ITCC study 021,
bortezomib in relapsed ALL
Annual I-BFM-SG meeting, DE,
Kiel, 16-5-2013,
Pediatric APL
Annual I-BFM-SG meeting, DE,
Kiel, 17-5-2013
Study Relapsed AML 2010/01
Annual I-BFM-SG meeting, DE,
Kiel, 17-5-2013
Chairman
Annual I-BFM-SG meeting, DE,
Kiel, 17-5-2013
Differences in treatment of
pediatric and adult APL
4th international meeting on
LeGBemia, Lymphoma and
Myeloma, TR, Istanbul, 24-5Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 81
Associate
Title / topic lecture
Meeting
URL meeting /
program
2013
Kluytmans, JAJW
Acute LeGBemias
Grand Round Dr. Sardjito
Hospital, ID, Yogyakarta, 30-72013
Kinderoncologie
jaarlijkse cursus Oncologie IKNL,
NL, Amsterdam, 30-9-2013
Pediatric acute promyelocytic
leGBemia
Annual SIOP meeting, keynote
lectures, CN, Hong Kong, 28-92013
International Ped AML Study 01
Steering committee International
Pediatric AML Group meeting
2013, NL, Amsterdam, 2/3-102013
Shared care
Landelijke SKION dag shared
care, NL, Amsterdam, 15-112013
Is it possible to achieve a target
"zero"MRSA and SSI in "real life"?
ECCMID. DE, Berlin, 27-4-2013
Guidelines and formulary
positioning of anti-staphylococcal
antibiotics
ECCMID, DE, Berlin, 27-4-2013
Antibiotic-resistant
microorganisms in meat, vegetable
and soil: social and political Impact
ECCMID, DE, Berlin, 27-4-2013
Prevention of surgical site
infections (SSIs): health economics
impact
ICPIC, CH, Geneva, 25/28-062013
Resistentie in de dagelijkse praktijk Congres bacteriën onder de loep,
van cure en care
NL, Utrecht, 22-5-2013
Lammertsma, AA
Antimicrobial Resistance: A new
zoönosis?
HAI, FR, Annecy, 23-6-2013
An overview of resistance and
animals
ICPIC, CH, Geneva, 25 t/m 28-062013
What we published is not what we
do; science versus real-life practice
ICPIC, CH, Geneva, 25 t/m 28-062013
Basic principles and kinetic
modelling
NVKF thema-middag
“Ontwikkelingen in PET, NL,
Eindhoven, 15-3-2013
Non-invasive assessment of the
Blood-Brain Barrier using Positron
Emission Tomography
BBBNedwork meeting, NL,
Leiden, 22-3-2013
Quantification in PET imaging
U930 symposium “PET image
processing” , FR, Tours, 27-32013
Quantification versus simplification
BrainPET 2013, Shanghai, 20-52013
College Delft, NL, Delft, 12-62013
Plasma input and reference tissue
compartment models
World Molecular Imaging
Congress 2013,
Savannah, 18-9-2013
Positron emission tomography:
principles and future directions,
Targeted Network Meeting
Obsessive Compulsive and Related
Disorders (OCRN)
European College of
Neuropsychopharmacology, SP,
Barcelona, 4-10-2013
Forward to the past
Philips meeting, EANM 2014, FR,
Lyon, 21-10-2013
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 82
Associate
Title / topic lecture
Meeting
Langius, JAE
Malnutrition and oropharyngeal
cancer
Symposium NESPEN-NVGE, NL,
Veldhoven, 22-3-2013
Leemans, CR
10-Year Results of The Two EORTC
Larynx Preservation Trials (EORTC
24891 and 24954)
4th International conference on
Innovative Approaches in Head
and Neck Oncology (ICHNO) , SP,
Barcelona, 7-2-2013
Human Papilloma Virus: Clinical
and Biologiscal Aspects
Mediterranean Alps Cancer
Conference - from Bed to Bench:
Biological-clinical interactive
exchanges and therapeutic
progress in head and neck
cancer and burning issures in
medical oncology, IT, Cuneo, 143-2013
Surgical salvage for head and neck
tumors after organ preservation
strategies
The 30th Alexandria
International Combined ORL
Congress, EG, Alexandria, 10-42013
Adenoid cystic carcinoma of the
head and neck: The Amsterdam
Experience
The 30th Alexandria
International Combined ORL
Congress, EG, Alexandria, 10-42013
Panel: Unusual presentation of
head and neck masses
The 30th Alexandria
International Combined ORL
Congress, EG, Alexandria, 10-42013
Management of parapharyngeal
tumors
The 30th Alexandria
International Combined ORL
Congress, EG, Alexandria, 10-42013
Advanced oropharyngeal cancer:
What's new?
The 30th Alexandria
International Combined ORL
Congress, EG, Alexandria, 10-42031
EHNS-AlexORL conjoint panel:
Controversy in the management of
cancer larynx
The 30th Alexandria
International Combined ORL
Congress, EG, Alexandria, 10-42013
Improving Head and Neck Cancer
outcome - a European perspective:
The Make Sense Campaign
4th World Congress of the
International Academy of Oral
Oncology. GR, Rhodos, 15-52013
Quality of Life in Head and Neck
Cancer: How Should it Be Best
Used?
20th World Congress of the
International Federation of OtoRhino-Laryngological Societies
(IFOS) Collegium Oto-RhinoLaryngologicum Amicitiae
Sacrum: Regeneration,
Restoration and Rehabilitation in
Otorhinolaryngology, KO, Seoul,
1-6-2013
Surgical Management of Squamous
Cell Cancer of the Oral Cavity
EHNS-ESMO-ESTRO Teaching
Course on Multidisciplinary
Management of Head and Neck
Oncology, HU, Budapest, 30-62013
Surgical Management of Squamous
Cell Cancer of the Oropharynx
EHNS-ESMO-ESTRO Teaching
Course on Multidisciplinary
Management of Head and Neck
Oncology, HU, Budapest, 30-62013
Morbidity after Surgery
EHNS-ESMO-ESTRO Teaching
Course on Multidisciplinary
URL meeting /
program
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 83
Associate
Title / topic lecture
Meeting
URL meeting /
program
Management of Head and Neck
Oncology, Hungary, Budapest,
30-6-2013
Management of Recurrent Tumours EHNS-ESMO-ESTRO Teaching
Course on Multidisciplinary
Management of Head and Neck
Oncology, HU, Budapest, 30-62013
Lems, WF
Management of Salivary Gland
Tumors
European Meeting on Oral
Diseases; Diagnosis and
Management, NL , Amsterdam, 49-2013
Case Discussion on the Neck
6th European Head and Neck
Course, NL , Amsterdam, 18-92013
Oral Cancer
6th European Head and Neck
Course, NL , Amsterdam, 18-92013
Case Discussion on Oral and
Oropharyngeal Cancer
6th European Head and Neck
Course, NL , Amsterdam, 18-92013
Parapharyngeal Space Tumours
6th European Head and Neck
Course, NL , Amsterdam, 18-92013
Salvage Following Chemoradiation
6th European Head and Neck
Course, NL , Amsterdam, 18-92013
The Role of Biological Imaging in
the Assessment in Head and Neck
Cancer
17th ECCO - 38th ESMO - 32nd
ESTRO European Cancer
Congress (ECC2013) , NL ,
Amsterdam, 27-9-2013
Surgical Management of Squamous
Cell Cancer of the Oral Cavity
EHNS-ESMO-ESTRO Teaching
Course on Multidisciplinary
Management of Head and Neck
Oncology, IN, Indore, 27-10-2013
Debate: This house believes that
neck dissection shoud take place
regardless of response to
(chemo)radiation
4th Trends in Head and Neck
Oncology, HR, Dubrovnik, 7-112013
Role of surgery in organ
preservation
4th Trends in Head and Neck
Oncology, HR, Dubrovnik, 7-112013
Clinical Cases
4th Trends in Head and Neck
Oncology, HR, Dubrovnik, 7-112013
Advanced oropharyngeal cancer:
What's new?
Fifth Head and Neck Cancer
Update, IN, Guwahati, 30-112013
Surgical salvage for head and neck
tumors after organ preservation
strategies
Fifth Head and Neck Cancer
Update, IN, Guwahati, 30-112013
Treat to target in RA, and
Osteoartritis/Osteoporosis, what is
new?
SA, Damman, 12/13-2-2013,
Biologicals and Bone in rheumatoid
arthritis
ECTS 2013, PT, Lisbon, 18-52013
The value of the fracture outpatient EULAR, SP, Madrid, 6-2013
clinic?
The BeSt study – focus on
contribution of Glucocorticoids
Steroids in NeuroEndocrinology,
Immunology and Treatment in
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 84
Associate
Title / topic lecture
Meeting
URL meeting /
program
Reumatic Diseases, IT, Genoa, 310-2013
Mebius, R
Meijer, CJLM
The relationship between joint
space narrowing and erosions in
RA
International Congress on Bone
Involvement in Arthritis, IT,
Genoa, 15-10-2013
Crucial interactions between
stromal and immune cells
BTCure workshop Amsterdam,
NL, Amsterdam, 18/19-3-2013
Control of mucosal immune
responses by vitamin A
International congress of
Immunology, IT, Milan, 22/2708-2013
Microenvironemntal control of the
immune system
3rd International lymphoid tissue
meeting, NL, Rotterdam,
15/17-09-2013
Microenvironemntal control of the
immune system
Lymphoid tissue workshop, BE,
Gent, 10-10-2013
2-dose HPV vaccination schedule
GSK scientific advisory Board
meeting, GB, London, 4-4-2013
Review of RCT in primary cervical
screening comparing cytology and
HPV screening
HPV workshop, CZ, Prague, 124-2013
chairman PA panel
Cotane lymfoompanel, NL, 5-62013
HPV DNA typing: is there a role for
it in cervical cancer screening
18th International Congress of
Cytology, FR, Paris, 26/30-52013
Longitudinal studies with p16
based cytology in cervical cancer
screening
18th International Congress of
Cytology, FR, Paris, 26/30-52013
HPV diagnostics in high and low
income countries
Key Opinion leader summit,
Women’s Health and STI
Workshop, Qiagen, CA, Niagara
on the Lake, Ontario, 19-9-2013
HPV in Women's Health
Key Opinion leader summit,
Women’s Health and STI
Workshop, Qiagen, CA, Niagara
on the Lake, Ontario, 19-9-2013
HPV for decision making in
screening and management
Eurogin, IT, Florence, 3/6-112013
Prevention strategies for HPV;
Implementation policies and
priority
Eurogin, IT, Florence, 3/6-112013
Molecular based strategies for
primary screening of cervical
cancer; risk-based screening
strategies
Eurogin ,IT ,Florence, 3/6-112013
Controversies in cervical cancer
screening and prevention/ priority
setting for cervical cancer control:
developed vs developing countries;
cytology versus HPV testing – high
income countries (HIC)
Eurogin, IT, Florence, 3/6-112013
5.Management options for women
with HPV positive screening
results; cytology
Eurogin. IT, Florence, 3/6-112013
From cytology to full molecular
screening
Evolving Views: New perspectives
in breast and
Gynaecopathology,Postgraduate
course Menarini, FR, Nice, 28/3011-2013
www.ici2013.org/ho
me/
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 85
Associate
Meijer, GA
Title / topic lecture
Meeting
Current and future perspectives in
HPV testing in self-collected
specimen
Symposium cervical cancer
screening, TH, Bangkok, 15/1701-2013
Molecular Screening for Coloractal
Cancer in the Faeces
Pathological society Winter
Meeting, NL, Utrecht, 9-1-2013
Applied molecular biology of
colorectal cancer, from screening
to therapy selection
LIMM Seminar, GB, Leeds, 21-22013
Translational research
TranSMART foundation F2F
meeting, IT, USA, Ann Arbor, 122-2013
TraIT & TranSMART
Bio-IT World Pre-conference
workshop, USA, Boston, 9-4-2013
The charity perspective on
translational research
Inaugural EATRIS meeting, NL,
Amsterdam, 4-6-2013
URL meeting /
program
Introductionary speech; Pathologist TranSMART developer and user
Avatar Vision
meeting, NL, Amsterdam, 17-62013
Translational research
BioMedBridges/TranSMART
meeting on IT solutions for
handling personalized Medicine
data, IT, DE, Dusseldorf, 11-92013
Molecular high-risk hallmarks of
colonic polyps
WEO Colorectal Cancer Screening
Meeting, DE, Berlin, 11-10-2013
EBV and Parkinson Disease
4th European EBV meeting, NL,
Amsterdam, 17-6-2013
www.ebv2013.org
Epstein-Barr virus markers in
Nasopharyngeal carcinoma
diagnosis and monitoring
6th International Symposium on
Nasopharyngeal Carcinoma, TR,
Istanbul, 20-6-2013
www.npc2013.org/
Mol, BM
High-resolution SNP array profiling
identifies variability in
retinoblastoma genome stability
International Society for Genetic
Eye Diseases & Retinoblastoma
(ISGEDR) meeting, BE, Ghent, 2408-2013
Moll, A
LeGBocoria: retinoblastoma?
European Paediatric
Ophthalmological Society, NL,
Leiden, 12-10-2013
Retinoblastoma and Pseudotumors
Congress Intraoculair tumors, IT,
Siena, 7-12-2013
Characterization of
retinoblastomas without RB1
mutations: genomic, gene
expression and clinical studies
NOG 2013, NL, Groningen, 2103-2013
Neil Smith Lecture: Lentiginous
Melanoma
93rd Annual Meeting of the
British Association of
dermatologists, GB, Liverpool, 97-2013
Neil Smith Lecture: Lentiginous
Melanoma
93rd Annual Meeting of the
British Association of
dermatologists, GB, Liverpool, 97-2013
Case presentations
British Society for
Dermatopathology, GB,
Liverpool, 8-7-2013
Update on Melanocytic Lesions
Pathological Society of Great
Britain and Ireland, joint meeting
with the British Division of the
International Association of
Pathologists, GB, Edinburgh, 216-2013
Middeldorp, JM
Mooi, WJ
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 86
Associate
Morré, SA
Title / topic lecture
Meeting
Case presentations
Pathological Society of Great
Britain and Ireland, joint meeting
with the British Division of the
International Association of
Pathologists, GB, Edinburgh, 216-2013
Squamous Cell Carcinoma, Basal
Cell Carcinoma and Its Differential
Diagnosis
Seminar, Workshop and
masterclass: Dermatopathology,
GE, Tbilisi, 14-11-2013
Melanoma, Molecular Pathology
Seminar, Workshop and
masterclass: Dermatopathology,
GE, Tbilisi, 14-11-2013
Melanoma, Molecular Pathology
Seminar, Workshop and
masterclass: Dermatopathology,
GE, Tbilisi, 14-11-2013
Pathogenesis of cancer
Tbilisi State University, GE,
Tbilisui, 18-11-2013
Melanocytic Consultation Cases:
How to Approach Them
Manchester Pathology Update
Course 2013, GB
Manchester, 31-10-2013
Case presentations
Manchester Pathology Update
Course 2013, GB, Manchester,
31-10-2013
Melanoma: Pathological Dilemmas
EuMEET Amsterdam 2013, NL,
Amsterdam, 10-12-2013
Chlamydia immunogenetics
MINC, NL, Maastricht
Chlamydia detection
ISSTDR, AT, Vienna
Chlamydia detection
Roche Geneva, CH, Geneva
Mostert, S
Influence of Health-Insurance
Access and Hospital Retention
Policies on Childhood Cancer
Treatment in Kenya
SIOP congress, CN, Hongkong,
26-9-13
Ossenkoppele, GJ
AML in the elderly is it a different
disease?
Acute leGBemia Conference, DE,
Munchen, 26-2-2013
new treatment modalities in AML
7th Dutch hematology congre,
NL, Arnhem, 24-1-2013
1. MRD as a predictor of survival in
AML, 2.A randomized, open-label,
phase II multicentre study with a
safety run-in to assess the
tolerability and efficacy of the
addition of oral lenalidomide to
standard induction therapy in AML
and RAEB ≥ 66 years and very
poor-risk AML ≥ 18 years (HOVON
103/SAKK428
Celgene 5th investigator
meeting), BE, Brussels, 9-3-2013
The importance of MRD
FDA Workshop on MRD, USA,
Washington, 4-3-2013
LeGBemic niche and potential
markers of malignancy
European CML Expert Summit,
GR, Athens, 24-5-2013
Applying MRD to outcomes and
follow-up: prognostic and
predictive
AML discovery Working group
meeting, NL, Lijnden, 28-6-2013
AML a glimpse into the future
University of Oslo leGBemia
symposium, NO, Oslo, 24-102013
Evaluation of therapeutic response
in hematology
Czech Society of hematology, CZ,
Prague, 10-10-2013
Hematology Training in Europe:
Italian Society of hematology, IT,
URL meeting /
program
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 87
Associate
Pegtel, M
Peters, GJ
Reijneveld, JC
URL meeting /
program
Title / topic lecture
Meeting
Different models towards a single
CV passport
Verona, 20-10-2013
Standard risk AML – should
transplant decisions be made on
MRD assessment
GB hematology Forum, GB,
London, 11-11-2013
Tumor Exosomes Biology
Prof. Ingemar Enberg, Karolinska
Institute, SE, Stockholm,
Karolinska, 2013
Exosome & EBV infection
Infection and Immunity
symposium 2013, NL, Utrecht,
2013
Tumor Exosomes carry RNA
biomarkers
Molecular medicine, Select
Biosciences, DE, Frankfurt, 2013
Exosomes in Autoimmunity
American Association of Cell
Biology, USA, San Fransisco,
2013
Exosomes in Viral Infection
Medical Immunology Meeting,
NL, Santpoort, 2013
Understanding the mechanism of
drug resistance
Department of Genetics - Basque
University, SP, Bilbao, 29-1-2013
The role of transport in drug
resistance
Department of Genetics - Basque
University, SP, Bilbao, 29-1-2013
Novel developments in the use of
antimetabolites in the treatment of
cancer
International Symposium on
Purine and Pyrimidine
Metabolism, SP, Madrid, 6-62013
www.ppsociety.org
Discussion on treatment of
Pancreatic ductal adenocarcinoma
(PDAC),
ECCO - Proffered paper session
Gastroinitestinal Malignancies Noncolorectal cancer, NL,
Amsterdam, 1-10-2013
eccamsterdam2013.e
cco-org.eu/ScientificProgramme/Searchab
leProgramme.aspx#anc
horScpr
Drug transporters in tumor
resistance, their roles in
personalized chemotherapy
Seminar at University of
Barcelona - Institute of
Biomedicine and Oncology
Programm, SP, Barcelona, 2-102013
Determinants of the efficacy of
tyrosine kinase inhibitors: uptake,
metabolism, the target?
The European Society for
Translational Medicine (EUSTM)
Annual conference EUSTM-2013,
LU, Luxembourg, 14/16-10-2013
www.eutranslational
medicine.org/prelimi
nary-agenda-2
Cytidine deaminase and
gemcitabine, SE, Lund, 20-12-2013
Mini symposium on metabolism
of Nucleic Acid Precursors
www4.lu.se/o.o.i.s?id
=22418&list_mode=i
d&calendar_id=1283
2
Intraparenchymateuze
hersentumoren; aanvullende
behandelingen
Cursorisch onderwijs
Nederlandse Vereniging voor
Neurochirurgie Assistenten. NL,
Bergen aan Zee, 23-5-2013
Damage to CNS and PNS from old
and new antineoplastic agents
23rd annual meeting European
Neurological Society. SP ,
Barcelona, 11-6-2013
www.congrexswitzerland.com/ens
2013.html
Report on workshop on Cancer
Survivorship
EORTC Quality of Life Group Fall
2013 Meeting, GB, Canterbury,
13-9-2013
groups.eortc.be/qol/
Quality of life as primary outcome
in brain metastases trials?
EORTC Brain Metastases Platform
Meeting, FR
Marseille, 20-9-2013
brain-mets.com/
Incorporation of quality of life and
neurocognitive function testing in
Central Nervous System
malignancies conference. AT,
www.seronosymposia
.org/en/oncology/liv
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 88
Associate
Rustemeyer, T
Savelkoul, PHM
URL meeting /
program
Title / topic lecture
Meeting
brain tumor studies
Vienna, 26-10-2013.
eevents/symposia/20
13-central-nervoussystem-cnsmalignancies.html
Pitfalls and solutions in HRQOL
measurement of patients in brain
tumor clinical trials
4th quadrennial meeting of the
World Federation of NeuroOncology (WFNO) , USA, San
Francisco, 21-11-2013
www.soc-neuroonc.org/2013annual-meeting/
QOL monitoring and intervention
at a multidisciplinary neurooncology outpatient’s clinic'
4th quadrennial meeting of the
World Federation of NeuroOncology , USA, San Francisco,
22-11-2013 (WFNO)
www.soc-neuroonc.org/2013annual-meeting/
allergische contact dermatitis de
rol van epicutaan onderzoek
, NL, Utrecht, 17-1-2013
contact allergie
Nederlandse Vereniging voor
Allergologie, NL, BreGBelen, 153-2013
Voedsel-intolerantie en- allergie.
Mechanismen, kliniek en
diagnostiek
Annual Dutch-Tropical
Dermatology meeting, SR,
Paramaribo, 22/24-04-2013
Contact Urticarieel Syndroom
(CUS), SR, Paramaribo
Annual Dutch-Tropical
Dermatology meeting, 22/24-042014
Richtlijn Contacteczeem - een
samenvatting voor de praktijk
Dermatologendagen, NL,
Papendaal, 12-04-2013
Palladium allergy
Experimental European Contact
Dermatitis Research Group, DK,
Odense , 19/20-04-2013
Work and Consumer Exposure
Occupational and Environmental
Exposure of Skin to Chemicals
(OEESC) , NL, Amsterdam, 3-062013
Current situation in the
Netherlands
Current scientific challenges of
occupational skin diseases (OSD)
in Europe, DE, Berlin , 18/20-092013
immunologischen Grundlagen der
Kontaktallergologie
Swiss Dermato-Allergological
course, CH, Basel, 18-09-2013
Palladium allergy
Experimental European Contact
Dermatitis Research Group, CH,
Basel, 19/20-4-2013
European Baseline Series
Experimental European Contact
Dermatitis Research Group, CH,
Basel, 19/20-4-2014
Innovative model to predict and
detect contact allergy
Stichting Nederlandstalige
nascholing voor dermatologie en
venereologie, NL, Amsterdam,
07-11-2013
Over bacteriën en de rol van
typeren
Bvf symposium, NL, Maastricht,
14-3-2013
Van proef naar product
symposium "Van idee naar METC;
samen vooruit in wetenschap",
NL, Alkmaar, 19-4-2013
Infectious diseases in the 21st
century
Mosa Conference, NL, Maastricht, www.mosa12-6-2013
conference.nl/work/
mosa-conference2013-2/
Nieuwste ontwikkelingen in de
microbiologie
Symposium "Vernieuwbouw in de
microbiologie" , NL, Izore
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 89
Associate
Title / topic lecture
Meeting
URL meeting /
program
laboratorium, 8-6-2013
Gezondheid
Oratie Paul Savelkoul, NL,
Maastricht, 13-9-2013
Bugs and chronic diarrhea in the
Western world: an overview
Falk Benelux Symposium Chronic
Diarrhae in adults, NL
Eindhoven, 12-12-2013
Scheper, RJ
Immunopathogenesis of Allergic
Contact Dermatitis
12th Asia-Pacific Environmental
and Occupational Dermatology
Group Symposium (APEODS) , IN,
Yogyakarta, 24 October 2013
Schulten, EAJM
Management of odontogenic cysts
and tumours
European Meeting of Oral
Diseases. Amsterdam, NL,
Amsterdam, 4/6-9-2013
Management of odontogenic
tumours
European Head and Neck Course,
NL, Amsterdam, 19-9-2013
MRD in AML: Results in a
prospective multicenter clinical
study (HOVON/SAKK). Future
Perspectives),
European LeGBemiaNet (ELN)
Mannheim (Germany). DE,
Mannheim, 5-2-2013
MRD and leGBemia stem cells in
AML,
Berlin Frankfurt Munich (BFM)
meeting DE, Kile, 16-5-2013.
Flowcytometric definition of the
leGBemia stem cell in acute
myeloid leGBemia
European Society for Clinical Cell
Analysis (ESCCA) , LU,
Luxemburg, 13-11-2013
Radiobiological aspects
VMAT/RAPIDARC - advantages,
implementation, tips and tricks ,
NL, Amsterdam , 13-09-2013
Radiobiological considerations
IMRT hands-on-course, NL,
Haarlem , 11-5-2013
Smit, L
Reunion Hans Clevers
Breakthrough Symposium, NL,
Amsterdam, 7-9-2013
Snijders, PJF
The future of molecular screening;
Making screening easier and more
objective
Symposium ‘HPV primary
screening: belangrijke besluiten
en kritische consequencties’, NL,
Utrecht, 6-3-2013
Current and future perspectives of
HPV testing
Annual meeting Thai Gynecologic
Cancer Society: Future direction
of Gynecologic Oncology, TH,
Pattaya, 11-8-2013
Een unieke test voor
baarmoederhalskanker screening:
vrouwvriendelijk en kosteneffectief
Health&Technology meeting
2013, NL, Papendal (Arnhem),
18-9-2013
HPV DNA strategies in screening
for detection of precursor lesions
of cervical cancer
XIII Argentine Congress of
Microbiology, AR, Buenos Aires,
26-9-2013
HPV and cervical cancer
epidemiology
V International Seminar
'Screening programs based on
HPV Test: tools for an effective
implementation', AR, Tucuman,
30-9-2013
HPV Test introduction in
Netherlands: how and why?
V International Seminar
'Screening programs based on
HPV Test: tools for an effective
implementation',AR, Tucuman,
30-9-2013
Translational research pipeline
leading to a molecular screening
test for cervical cancer : the
experience of 25 years
EATRIS biomarker platform
meeting, SP, Madrid, 18-10-2013
Schuurhuis, GJ
Sminia, S
www.minc.eu/oratie/
page3.html
expired
www.hat-event.com
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 90
Title / topic lecture
Meeting
URL meeting /
program
HPV screening: current and future
perspectives
EUROGIN 2013, IT, Florence, 311-2013
www.eurogin.com/20
13/
New biomarkers in HPV screening
EUROGIN 2013, IT, Florence, 411-2013
www.eurogin.com/20
13/
Testing for HPV oropharyngeal
cancer – pearls, pitfalls and
progress
EUROGIN 2013, IT, Florence, 411-2013
www.eurogin.com/20
13/
The rationale for clinical validation
of high-risk HPV tests
Abbott Molecular Satellite
Symposium at EUROGIN 2013, IT,
Florence, 4-11-2013
The value of HPV genotyping in
self-samples of screening nonattendees
EUROGIN 2013, IT, Florence, 511-2013
Steenbergen, R
DNA methylation markers
Eurogin, IT, Florence, 5-11-2013
Taphoorn, MJB
Quality of Life in Gliomas
New trends for the treatment of
CNS tumors, IT, Bologna, 8-112013,
te Riele, H
A novel mouse model to study
prevention strategies for intestinal
cancer in Lynch syndrome
Nederlandse Vereniging voor
Gastroenterology, NL, Veldhoven,
04-10-2013
Oligonucleotide directed gene
targeting: evading mismatch repair
Seventh workshop on innovative
mouse models, NL, Leiden, 1406-2013
Retinoblastoma: a genomic
instability syndrome?
UMCG Seminar Series, Groningen
University, NL, Groningen, 24-012013
Superior and long-term tumor
control by combining DC-SIGN
targeting vaccines with transient
inhibition of regulatory T cells
43rd Annual Meeting. German
Society for Immunology, DE,
Mainz, 13-09-2013.
domains.conventus.d
e/fileadmin/media/2
013/dgfi/Programm/
DGfI_2013_Program
mheft.PDF
Uptake of sialylated antigens
induces tolerogenic function on
dendritic cells promoting
regulatory T cell
Wintermeeting Nederlandse
Vereniging voor Immunologie,
NL, Noordwijkerhout, 18-122013
www.dutchsocietyim
munology.nl/agenda
/nvvi-annualmeeting2013/4396_nvviannual-meeting-2013
ShrinkBayes: Bayesian analysis of
high-dimensional data using
multiple shrinkage priors
Journee de Statistique, FR,
Toulouse, 30-5-2013
jds2013.sfds.asso.fr/
?lang=en
ShrinkBayes: Bayesian analysis of
high-dimensional data using
multiple shrinkage priors
European BioConductor meeting,
GB, Cambridge, 12-9-2013
sites.google.com/site
/eurobioc2013/timet
able
ShrinkBayes: Bayesian inference for
(zero-inflated) count-based
sequencing data in complex study,
designs
Symposium Statistical analysis of
RNAseq data, Institute Pasteur,
FR, Paris, 26-11-2013
www.pasteur.fr/ip/re
source/filecenter/doc
ument/01s-00004s01p/programme-pf226-11-13-fin.pdf
ShrinkBayes: Bayesian differential
expression analysis of RNA
sequencing data, plus extensions
to networks
IBS channel network conference,
GB, St. Andrews, 7-4-2013
bir.biometricsociety.o
rg/events/channelnet
workconference
Data Integration: from Nice Figures
to Real Conclusions
CMSB meeting, NL, Leiden, 1510-2013
www.cmsb.nl/events/
2-cmsb-10th-annualsymposium/
Research in AS
British /Dutch Arthritis
foundation, GB, Manchester, 1411-2013
lectures on Uveitis in
Spondylarthopathy, psoriasis in
ASAS international Educational
Courses, TR, Istanbul, 26/28-11-
Associate
Unger, W
van de Wiel, M
Van der Horst-Bruinsma, IE
www.eurogin.com/20
13/
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 91
Associate
Van der Laken, J
Title / topic lecture
Meeting
SpA, Treatment of SpA, Diagnosis
of SpA
2013
The role of Physiotherapy in AS
Symposium prof van der Linden,
NL, Maastricht, 13-12-2013
Overview of presentations and new
developments
American Conference of
Rheumatology, NL, Ameland, 112013
Imaging van inflammatoire
reumatische ziekten
National Rheumatology
Education and Learning (REAL)
symposium, 1-2013
Positron Emission Tomography of
inflammatory rheumatic diseases
Society of Nuclear Medicine, BE,
Brussels, 3-2013
van der Sar, AM
Modeling tuberculous meningitis in Zebrafish Disease Models 6, SP,
the zebrafish-Mycobacterium
Murcia, 17-07-2013
marinum infection model
Van der Waal I
Maligne en premaligne afwijkingen
Openingssymposium afdeling
MKA Bronovo, NL, Den Haag, 1311-2013 ziekenhuis
Oral leGBoplakia; an update; the
nonsquamous cell oral cancers
Spanish Association of Oral
Medicine, SP, Santiago de
Compostela, 17-5-2013
URL meeting /
program
www.zdm6.imib.es/
Current concepts of oral potentially 1st International Symposium of
malignant disorders; diagnosis and the Oral Diseases Group of
management
Thailand, TH, Bangkok, 4-112013
van Die, I
van Dulmen-den Broeder, E
van Egmond, M
Lichen planus and lichenoid
lesions; leGBoplakia;
histopathology of odontogenic
cysts and tumors
European Meeting of Oral
Diseases, NL, Amsterdam, 5-92013
Mondkanker in de tandartspraktijk:
dat mag je niet missen Hoe kan
mondkanker eerder worden
opgespoord?
Mondkanker dat mag je niet
missen, NL, Rotterdam, 22-32013
Orale leGBoplakie; diagnostiek en
behandeling
2e Dermatologen-inopleidingdagen, NL, Amersfoort,
23-3-2013
Ulceraties van het mondslijmvlies;
een uitdaging voor de tandarts.
Klinisch-röntgenologische diaquiz;
bespreking van 10 casussen
NMT Jaarcongres 2013, NL, Zeist,
14-06-2013
De mond als spiegel van de
gezondheid
Afscheidssymposium A.G.
Dumans, NL, Rotterdam, 1-112013
Immunomodulation by Trichuris
suis: what are the M&M's
Hydra conference on Helminth
Immunomodulators, GR, Hydra,
28-08-2013 tot 01-09-2013
hydrathemes.bio.ed.ac.GB/
home
Glycans and galectins in metastasis 24th Joint Glycobiology Meeting,
of pancreatic cancer,
DE, Wittenberg, 24-11-2013 tot
26-11-2013
www.glycobiology20
13.net/
Infertility and premature
menopause
Focus on Rare diseases-Cancer
Survivorship Care, IT, Bergamo,
14/16-11-2013
www.hpg23.it/img/u
pload/files/247_Men
arini_programma_16
_ottobre_2013.pdf
De SKION-LATER VEVO Studie
SKION Prinses Maxima Research
Retraite, NL, De Bilt, 18/19-112013
Immunoglobulin A and FcaRI in
mucosal immunity revisited
Invited lecture University of
Liverpool, GB, Liverpool, 9-42013
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 92
Associate
van Furth, AM
URL meeting /
program
Title / topic lecture
Meeting
Immunoglobulin A and FcaRI in
mucosal immunity revisited
Invited lecture University of
Wageningen. NL, Wageningen,
26-09-2013
Macrophages prevent surgeryinduced liver metastasis
development after mAb therapy
Invited lecture Institut Pasteur.
FR, Paris, 30-10-2013
Keeping the balance between
protection and inflammation in the
gut; The role of the human IgA Fc
receptor FcaRI
Invited lecture University of
Connecticut Health Center. . USA,
Farmington
14-11-2013
Modeling Tuberculosis meningitis
in the zebrafish-Mycobacterium
Marinum infection model
Amsterdam Kindersymposium,
NL, Amsterdam, 21-2-2013
Development from an
Interdisciplinary Viewpoint
NL, Amsterdam,
14-1-2013
Multi-Level and ethod evaluation of
pediatric home-based care:
knowledge to action for health
Sustainable Rural Health
Research Day, SA , Worcester, 32013
A human prospective analysis of
the clinical spectrum of different
subtypes Enterovirus and Human
Parechovirus
ESPID, IT, Milan, 28/31-5-2013
www2.kenes.com/es
pid2013
Development of a rapid mulplex
polymerase chain reaction (PCR)
assay for accurate diagnosis of
neonatal sepsis. Going deeper,
simpler, faster and real micro:
molecular methods in diagnostic
bacteriology
ECCMID, DE , Berlin, 27/30-42013
www.congrexswitzerland.com/ecc
mid2013.html
Motorische ontwikkeling van
kinderen na een humaan
Enterovirus of Parechovirus
centraal zenuwstelsel infectie: een
prospectieve multicenter cohort
studie
Nederlandse Vereniging voor
Kindergeneeskunde (NVK) 35ste
congres, NL, Veldhoven, 6/8-112013
www.kinderartsenwet
enschap.nl
Ontwikkeling van een multiplex
PCR voor de diagnostiek van late
onset sepsis bij prematuren;
resultaten van de INFANT-studie
Nederlandse Vereniging voor
Kindergeneeskunde (NVK) 35ste
congres, NL, Veldhoven, 6/8-112013
www.kinderartsenwet
enschap.nl
amsterdamkindersym
posium.nl/
Development of a rapid multiplex
NL, Scheveningen
PCR assay for accurate diagnosis of
neonatal sepsis
van Grieken, NCT
van Kooyk, Y
The benefit of two PCR based
assays for the accelerated
diagnosis of tuberculous
meningitis
57 th Tygerberg Annual
Academic Day, SA, Cape Town,
14/15-8-2013
sun025.sun.ac.za/po
rtal/page/portal/Heal
th_Sciences/English/
Annual_Academic_Da
y
Managing Change at multiple
levels to make the transition from
in-hospital treatment to home
based care: lessons from South
Africa
57 th Tygerberg Annual
Academic Day, SA, Cape Town,
14/15-8-2013
sun025.sun.ac.za/po
rtal/page/portal/Heal
th_Sciences/English/
Annual_Academic_Da
y
Dutch Upper GI Audit
DICA congres, NL, Amsterdam,
24-6-2013
www.clinicalaudit.nl/
Gastric cancer histology: Does it
matter?
Gastric cancer treatment. Anno
2013 and beyond. NL, Utrecht,
10-4-2013
dgcg.nl/dgcg/sympo
sium-gastric-cancertreatment-201328dgcg29-flyer.pdf
Glycans for improving skin
vaccination strategies
100years the American Association
of Immunologists AAI Annual
Meeting, USA, Honololu, 3-52013
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 93
Associate
URL meeting /
program
Title / topic lecture
Meeting
Sugars and Lectins in
autoimmunity
Annual European Congress of
Rheumatology (EULAR2013) , SP,
Madrid, 12-6-2013
Skin vaccines to treat cancer
5th Twincore Symposium Mucosal
infection and Immunity, DE,
Hannover, 5-9-2013
Inhibitory and stimulatory glycans
that alter Dendritic cell induced
immune responses
Annual meeting of the Society for
Glycobiology (SfG), , USA, St
Petersburg, 17-11-2013
How Glycobiology meets
Immunology
15th International Congress of
Immunology, IT, Milan, 22-82013
Immune inhibitiory and
stimulatiory carbohydares that
affect dendritic cell function
12th international Workshop on
Carcinoma-associated Mucins,
GB, Cambridge, 27-7-2013
How discovery based
immunological research leads to
cancer treatment in the clinic
7th VU University Medical Center
Science Exchange Day, NL,
Amsterdam, 8-3-2013
nanoparticles targeting Dendritic
cells for anti-tumor vaccines
Drug delivery meeting NNI, NL,
Utrecht, 18-6-2013
DC targeting vaccines to improve
anti-cancer immunity
Invitation to the Ludwig Institute
for Cancer Research, CH,
Lausanne, 12-11-2013
Ulcus cruris venosum update
richtlijn
Eilanddagen dermatologie, NL,
Schiermonnikoog, 27/29-062013
www.peonline.org/public/
Nieuwe middelen tegen
gemetastaseerd melanoom
Themadag
Geneesmiddelenreacties
Stichting Nederlandstalige
Nascholing voor Dermatologie en
Venereologie, BE, ,Hasselt, 20-42013
www.snndv.nl/thema
dag2013/
Update dutch guideline venous
ulcers
Flebologie á la carte, NL,
Rotterdam, 24-9-2013
Differential diagnosis of the leg
ulcer
European Academy of
Dermatology and Venereology,
TR, Istanbul, 3-10-2013
Importance of dermatologist in
new era of melanoma treatment
European Melanoma experience
exchange focus on therapy, NL,
Amsterdam, 10/11-12-2013
van Schaardenburg, D
Prediction of future onset of
arthritis in individuals without
current arthritis
Annual Congress American
College of Rheumatology, USA,
San Diego, 26-10-2013
rheumatology.org
van Sörnsen de Koste, JR
Digital Tomosynthesis for verifying
lung tumor position
American Society for Radiation
Oncology, USA, Atlanta, 25-92013
www.softconference.
com/astro/am.asp
Van Vliet SJ
Tumor-associated glycans trigger
the C-type lectin MGL on dendritic
cells and dampen anti-tumor
immunity
Annual Meeting of the European
Macrophage and Dendritic Cell
Society (EMDS) , DE, Erlangen,
10/11/12-10-2013
www.emds2013.eu/
Tumor-associated glycans trigger
the C-type lectin MGL on dendritic
cells and dampen anti-tumor
immunity
Annual meeting of the Dutch
Society for Immunology (NVVI) ,
NL, Noordwijkerhout, 18/19-122013
www.dutchsocietyim
munology.nl/agenda
/nvvi-annualmeeting2013/4396_nvviannual-meeting-2013
Terug naar de toekomst
VHIG congres, NL, Egmond aan
Zee, 10-4-2013
van Montfrans, C
Vandenbroucke-Grauls,
CMJE
istanbul2013.eadv.or
g/
ECCMID, DE, Berlin, 29/30-42013
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 94
Associate
Verbakel, WFAR
Verdonck-de Leeuw, IM
Verweij, CL
Vis, AN
Wesseling, P
Title / topic lecture
Meeting
Lecture ESBL in The Netherlands
JPEMS, FR, Angers, 1/2-10-2013
Fundamentals of VMAT
XIV. National Medical Physics
Congress 2013, TR, Antalya, 2110-2013
VMAT treatment of head and neck
XIV. National Medical Physics
Congress 2013, TR, Antalya, 2110-2013
Daily setup errors and IGRT,
XIV. National Medical Physics
Congress 2013 TR, Antalya, 2210-2013
Collaborative Knowledge Modeling
and Integration for Radiation
Therapy Planning
AAPM 55th Annual Meeting &
Exhibition 2013, USA,
Indianapolis, 8-8-2013
Living with cancer
Clinical Psychology, NL,
Amsterdam, 16-9-2013
Quality of life in head and neck
cancer survivors
EORTC Meeting, GB, Canterbury,
11-9-2013
Distress: to screen or not screen
CCA evening lecture, NL,
Amsterdam, 9-5-2013
Psychosocial cancer care
Pittsburgh Department of
Psychiaty, USA, Pittsburgh, 14-52013
Living with cancer: innovative care
programs and eHealth
Clinical Oncology and
Hematology Grand Rounds, USA,
Pittsburgh, 15-5-2013
Netherlands Quality of Life and
Biomedical Cohort Studies in ,
Cancer
NWHHT meeting, NL, Rotterdam,
14-3-2013
Type I interferon in autoimmunity
European Federation of
Immunological Societies (EFIS) ,
FR, Paris, 7-2-2013
Tertiary lymphoid structures in
autoimmunity
the European League against
Rheumatism (EULAR, SP, Madrid,
14-06-2013
The type I interferon system to
predict therapy response and very
early diagnosis of disease
Seminar Program Karolinksa, SE,
Stockholm, 4-2-2013
Testosterone and prostate cancer:
myths and paradigms,
State of the art (SOTA),NL,
Weesheuvel, 1-2-2014
Testosterone and prostate cancer:
myths and paradigms
State of the art (SOTA) , NL, 1-102013
Result of 318 RALP in the VUmc,
pathology, operative outcome, and
functional and oncological
outcome
Refereeravond VUmc/ AMC, NL
Radium-223 en CRPC, de visie van
de uroloog
Meeting IKNL, NL
Botgezondheid en prostaatkanker
Refereeravond VUmc/ AMC, NL
“Diffuse Intrinsic Pontine Glioma;
Towards Improved Understanding
and Classification”
DIPG Conference, sponsored by
the Royal Dutch Academy for
Arts and Sciences, NL,
Amsterdam, 8/9-03-2013
“Glioma Growth, a Guerilla War;
Lessons Learned from a
Neuropathology Practice”
Glioma Invasion Forum, NO,
Bergen, 5/6/7-06-2013
“Gliomas; Don’t Be Fooled”, in
Symposium “Gliomas, Let’s Try To
Make Them Easy”
European Congress of Pathology,
PT, Lisbon, 2/3/4-09-2013
URL meeting /
program
www.medikalfizik201
3.org
www.aapm.org/meeti
ngs/2013AM/
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 95
Associate
URL meeting /
program
Title / topic lecture
Meeting
"Anti-angiogenic Therapy of Glial
Brain Tumors; Lessons Learned
from Human Glioma Xenograft
Models”,
11th European Congress of
Toxicologic Pathology BE, Gent,
10/11/12/13-09-2013
“Diffuse Glioma Growth; A Guerilla
War” (Key note lecture)
Educational Neurosciences
Symposium of the International
Society of Neuropathology, SA,
Johannesburg, 22/23-09-2013
“CNS Tumours in Adults – Recent
Developments Including Genetics
and Molecular Biology”, SA,
Johannesburg, 22/23-09-2013
Educational Neurosciences
Symposium of the International
Society of Neuropathology
"Important determinants of the
pathological diagnosis"
Educational Neurosciences
Symposium of the International
Society of Neuropathology, SA,
Johannesburg, 22/23-09-2013
“Diffuse Glioma Growth; A Guerilla
War”
National Spanish
Multidisciplinary Neuro-Oncology
Meeting, SP, Pamplona, 9/10/1110-2013
“Morphological and Molecular
Pathology of Gliomas”
VIth Evidence Based
Multidisciplinary NeuroOncology
Symposium, TR, Istanbul
1/2-11-2013
"Intratumoral heterogeneity in glial
tumors; a pathologist's ,
erspective"
National Working Group for
Neuro-Oncol. Investigators, NL,
Netherlands, 12-9-2013
PET imaging to support targeted
drug therapy
International Workshop on
Innovative Personalized
Radioimmunotherapy, FR,
Nantes, 9/12-7-2013
PET/SPECT imaging biomarker
development
9th annual conference in Imaging www.slideshare.net/
in cancer drug development, GB, CemTuna/smis-9thLondon, 13/14-9-2013
annual-imaging-incancer-drugdevelopment-event
Wondergem, MJ
AML case and discussion
ELN frontiers, CH, Prague, 11-102013
Ylstra, B
NGS for the detection of mutations
and copy number aberrations in
DNA isolated from FFPE solid
tumor specimens
NEXT GENERATION SEQUENCING, www.ecsaude.uminh
approaches and applications , PT, o.pt/Default.aspx?tab
Braga, 17-6-2013
id=8&pageid=943&la
ng=pt-PT
Intratumoral heterogeneity in lowgrade gliomas by shallow whole
genome sequencing
EMBO - 10th Golden Helix
Pharmacogenomics Day, NL,
Amsterdam (RAI), 23-9-2013
Intratumoral heterogeneity in lowgrade gliomas by shallow whole
genome sequencing
1st International workshop on
www.paoheyendael.nl
Cancer Genetic & Cytogenetic
/nl/bij-enDiagnostics, NL, Nijmegen , 22-3- nascholing/aanbod/
2013
Implementing NGS on FFPE
Tumour-Derived DNA for Mutation
Analysis in Routine Diagnostic
Pathology
Joint Meeting of the Pathological
Society of Great Britain & Ireland
and the Dutch Pathological
Society (NVVP) , NL, Utrecht, 8-12013
pathsoc.org/files/me
etings/scientificMeeti
ngs/utrecht2012/67
73%20PreN(Wint13Utrecht)%20v10%20[
web150].pdf
Intratumoral heterogeneity in lowgrade gliomas by shallow whole
genome sequencing
Symposium on Innovative
diagnostic and therapeutic
approaches in oncology, NL,
Maastricht, 19-12-2013
www.grow-um.nl/
Subclonal copy number aberrations
with prognostic value in diffuse
low-grade gliomas
Jaarvergadering; De Nederlandse
Vereniging voor Neurologie, NL,
Utrecht, 15-9-2013
www.neurologie.nl/p
ubliek/nvn/werkgroe
pen/neuro-
Windhorst, AD
www.emn.fr/zsubatech/wipr-2013/
www.goldenhelix.org
/index.php/news/lat
est-news
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 96
Associate
Title / topic lecture
Meeting
Zijlstra, JM
How to treat advanced stage
Hodgkin lymphoma
7th Dutch Hematology Congress,
NL, Papendal, 25-1-2013
Imaging of malignant lymphoma
Educational course Nuclear
medicine physicians, NL, UMCU
Utrecht, 8-3-2013
PET reponse monitoring in NHL
Jaarsymposium Hematologie, NL,
Utrecht, 19-9-2013
Treatment of the elderly Multiple
Myeloma patients – state of the art
Dutch Hematology Congress, NL,
Arnhem, 24-1-2013
What’s new for elderly patients
Multiple Myeloma Debate
meeting, DE, Berlin, 31-1-2013
URL meeting /
program
oncologie/
Zweegman, S
Randomized phase 3 trial in elderly International Myeloma Workshop,
NDMM comparing MPT followed by JP, Kyoto ,6-4-2013
T maintenance versus MPR
followed by R maintenance
The role of maintenance therapy
for patients with newly diagnosed
multiple myeloma, Satellite
symposium; Current and future
therapeutic strategies for multiple
myeloma
European Hematology
Association, SE, Stockholm, 13-62013
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 97
Awards
Associate
Name award
Awarded by, place, date
Avan, A
Chris Meijer Award
VUmc, Amsterdam, 02-09-2013
Beelen RHJ
Mid term award excellent
Brussel, Maastricht, 15-10-2013
Blauwhoff-Bustermolen, S
NVO Travelgrant
Nederlands Voedingsteam Overleg, Utrecht,
12-03-2013
Blufpand, H
Masterclass Amsterdam
Kindersymposium 2013, Amsterdam, 29-022013
de Gruijl, TD
Fenna Diemer Lindeboom Chair
FDL Program, 01-08-2013
Dekker, J
Distinguished International Affiliate
Division 38, American Psychological
Association
Special Contribution to China Behavioral
Medicine
Chinese Society of Behavioral Medicine, Xi'an,
01-08-2013
Gibbs, S
Fenna Diemer Lindeboom Chair
VUMC / ACTA, Amsterdam, 08-03-2013
Giovannetti, E
Berlucchi Award for Young Italian Researchers
Berlucchi Foundation, Brescia, Italy, 26-062013
Heideman, DAM
Klinisch moleculair bioloog in de pathologie
(KMBP)
NVVP, 2013
University Teaching Qualification (UTQ) (Basis
Kwalificatie Onderwijs (BKO)
2013
Klinisch moleculair bioloog in de pathologie
(KMBP)
NVVP, 2013
University Teaching Qualification (UTQ) (Basis
Kwalificatie Onderwijs (BKO)
2013
Meijer, GA
Eatris national co-director
Ministerie van OCW, 01-11-2013
Mooi, WJ
Dr Neil Smith Medal for outstanding
contributions to dermatopathology
The British Association of Dermatologists and
the British Society for Dermatopathology,
Liverpool, GB, 09-07-2013
Lifetime Honorary Membership Award
The British Society for Dermatopathology,
Liverpool, GB, 09-07-2013
Nielsen, K
Kanker in Beeld award
SVBBK, VUmc
Ossenkoppele, GJ
Prof Neuwirth Award
Czech Society of hematology, Prague, 10-102013
van Furth, AM
Associate professor extraordinary: paediatrics
and child health
Stellenbosch University, Tygerberg, South
Africa, Tygerberg, South Africa, 01-01-2013
van der Waal,I
Honorary membership
Spanish Association of Oral Medicine,
Santiago de Compostela, 17 May 2013
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 98
Obtained research funds, grants and contracts
Type of funding,
grant, contract
Project leader(s)
Title project
Budget
Bakema JE, Brakenhoff R, Braakhuis
B, Leemans CR
Het veranderen van de immunologische
omgeving van hoofd-halstumoren
waardoor patiënten beter reageren op
Cetuximab behandeling.
Fjoer stichting
€ 10.000
Bakema JE, Van Egmond M, van de
Loosdrecht AA, van der Steen L
TrisomAb-20, the more the merrier
CCA V-ICI 2013
€ 150.000
Bleeker MCG, Steenbergen R, van
Beurden M
Carcinogenisis vulvar cancer
ECC
Boellaard R, NAN
Establishing a multimodality preclinical
imaging facility for fundamental research
and efficient drug development
NWO Middelgroot
€ 1.2 M
Quantitative PET/MR: improving MR based
attenuation correction
Quantivision (IMDI)
€ 250 k
Bökenkamp A, Kaspers GJL
Nierfunctie meten bij kinderen
Fonds NutsOhra
Brakenhoff RH, Leemans CR,
Braakhuis BJM
Development of a personalized targeted
treatment for head and neck cancer
University funding
VUmc-CCA
Brakenhoff RH, Schaapveld R
MiRacle, Novel tumor-selective lethal
miRNAs for the treatment of head and
neck cancer
FP7-SME-2013-606486
Brakenhoff, RH, T Poli
OraMod, VPH based predictive model for
oral cancer reoccurrence in the clinical
practice
FP7-ICT-2013-10611425
Bultink IEM, Voskuyl AE, Bijlsma
JWJ, Tsang-A-Sjoe MWP
Landelijke implementatie van een
registratie voor SLE
Stichting
Kwaliteitsgelden
Medisch Specialisten
(VWS/Orde van
medisch specialisten)
€ 60.000
Cloos J
Splicing alterations as novel mechanism of
drug resistance
Stichting VUMC/CCA
€ 297.053
Application of bortezomib in pediatric
acute lymphoblastic leukemia
Stichting Kinderen
KankerVrij (KIKA)
€ 228.566
Ontrafelen van resistentie-mechanismen
tegen bortezomib bij multipel myeloom
Fonds Stimulans
Cloos J, Giovanetti E, Zweegman S,
Sciarrillo R
Splicing alterations as novel mechanism of
drug resistance
Stichting VUMC/CCA
€ 297.053
Cloos J, Kaspers GJL, Jansen G,
Niewerth D
Application of bortezomib in pediatric
acute lymphoblastic leukemia
Stichting Kinderen
KankerVrij (KIKA)
€ 228.566
Cloos J, Zweegman S, Jansen G
Unraveling bortezomib resistance
Grant from “Fonds
Stimulans” from the
Dutch Patient Multiple
Myeloma association
€ 30.000
Ontrafelen van resistentie-mechanismen
tegen bortezomib bij multipel myeloom
Fonds Stimulans
€ 30.000
Cloos J, Zweegman S, Sciarillo R
Splicing alterations as novel mechanism of
drug resistance
Co-PI CCA grant 2013
€ 290.000
de Jong D, Ylstra B
Molecular stratification for diffuse large Bcell lymphoma as a guide for treatment
choice.
VUmc
€ 250.000
den Haan JMM, Molthoff C
Roche study 5
Roche B.V.
den Haan JMM, van Kooyk Y
Development of a rapid and effective
prime-boost vaccination strategy for
melanoma
Dutch Cancer Society
€ 540.000
Douw L
Linking neurons to behavior through multi- Branco Weiss
scale brain networks
Fellowship (Society in
Science, managed by
€ 400.000
€ 85 000
€ 65.000
€ 30.000
€ 14.000
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 99
Project leader(s)
Type of funding,
grant, contract
Title project
Budget
ETH Zurich,
Switzerland)
€ 250.000
The molecules of behavior: how brain
tumors link cellular biology to large-scale
brain networks and cognition
NWO Veni
Fijneman RJA, Jimenez CR, Meijer
GA
Tumor-specific protein biomarkers for
early detection of colorectal cancer
project grant KWF
VU2013-6025
Forouzanfar T
Klinische inventarisatie van implantologie
bij Sjögrenpatiënten in Nederland
NUTS OHRA
Giovannetti E
Targeting key microRNA to combat
pancreas cancer ”
PI of the 5-months
extensionMarieCurie/A
IRC grant 2011
€ 8.000
Giovannetti E, La Laguna University,
Peters GJ, Leon LG, Padron JM
IMBRAIN grant n° 4319786
Participant European
Union FP7-REGPOT-Cal
€ 11.199.702
Grunberg K, Willems S (UMCU),
Willems, Nagtegaal, von der
Thusen, Hofhuis
Variation in grading of colon adenomas
Dutch Cancer Society
(KWF)
Heideman DAM
Improved molecular pathology diagnostics
for precision medicine (Verbeterde
moleculaire pathologie diagnostiek die
bijdraagt aan een zorg waar ‘therapie op
maat’ centraal staat).
Industrial grant
€5k
Hillebrand A, Reijneveld JC, Nissen
I
Identifying the epileptogenic zone in the
absence of epileptiform discharges; biasfree network analysis applied to interictal
MEG recordings
Dutch Epilepsy
Foundation
(Epilepsiefonds)
€ 203.000
Hulleman E
Groeifactoren als aangrijpingspunt voor de
behandeling van diffuus intrinsiek
ponsglioom
Zeldzame Ziekte Fonds
€ 100,000
Israels T
Collaborative Wilms tumour Africa Project
SIOP
€ 560K
€ 150.000
€ 67.500
t.b.d.
Janssen JJWM
Side studies to the CML NordDutch 009
study
Novartis
€ 650.000
Janssen JJWM, van Agtmael M,
Kramer M, de Jonge N
Early discontinuation vs. extended
treatment with imipenem for unexplained
fever during neutropenia in hematology
patients receiving antimicrobial
prophylaxis: a randomized non-inferiority
trial.
ZonMW GGG
€ 238.000
Jenster G, Ylstra B, Fijneman R,
Meijer GA
NGS ProToCol
CTMM NGS-ProToCol
€ 900.000
Jimenez CR, Jonkers J, van Diest PJ
Discovery and clinical validation of novel
protein biomarkers for homologous
recombination deficient breast cancer
project grant KWF
VU2013-6020
Jimenez CR, Verheul HMW, Boven E
In-depth quantitative (phospho)proteomics
in tumors to detect proteins indicative for
everolimus sensitivity or resistance
pharmaceutical
research (side study
Novartis)
€ 55K
Jimenez CR, Verheul HMW,
Eerthwegh F
Phosphoproteomics for vemurafenib
response prediction in melanoma
pharmaceutical
research (side study)
€ 100K
Jordanova ES, Kenter GG, de Gruijl
TD, Heeren M
Translating immune characteristics of
metastatic tumour cells into therapeutic
targets for cervical cancer
KWF/NKB research
grant
€ 440,000
Kaatsch P (overall coordinator),
Byrne J (research coordinator), van
Dulmen-den Broeder E
PanCare Studies in Fertility and Ototoxicity
to Improve Quality of Life after Cancer
during Childhood, Adolescence and Young
Adulthood
PanCareLIFE (WP3
leader)
€ 599.162
Kaspers GJ, van den Berg MH,
Abbink F
Reducing vincristine-induced peripheral
neuropathy in children with acute
lymphoblastic leukemia by one-hour
infusions instead of bolus
ZonMw Goed Gebruik
Geneesmiddelen
€ 317.616
€ 560K
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 100
Project leader(s)
Type of funding,
grant, contract
Title project
Budget
injectionsReducing vincristine-induced
peripheral neuropathy in children with
acute lymphoblastic leukemia by one-hour
infusions instead of bolus injections
Kaspers GJL
Mebius RE
€ 317.616
Reducing vincristine-induced peripheral
neuropathy in children with acute
lymphoblastic leukemia by one-hour
infusions instead of bolus injections
ZonMw (programma
Goed Gebruik
Geneesmiddelen
Compliance with childhood cancer
treatment in Manado
SMALL Foundation
High resolution 3D imaging of large
fluorescently stained tissues
Research grant for
equipment, ZonMW
middelgroot
€ 270.000
The role of retinoic acid in lymphatic
vasculature development
Research grant, ALW
program
€ 253.465
University Research
Fellow program
€ 40.000
Meijer C
€ 3.328
€ 1.634.848
Meijer C, Berkhof J
Comparing health services intervention for
the prevention of HPV related cancer
COHEAR, FP7,HealthF3-2013-603019
Meijer C, Berkhof J, Polman N
Comparing health services interventions
for the prevention of HPV-related cancer
FP7-HEALTH-2013INNOVATION
Meijer GA, Carvalho B, Jimenez CR
CRC bioscreen
CTMM
€ 315.000
Middeldorp JM, de Boer JP, Greijer
AE, Novalic Z
Trial support: New therapy for Epstein-Barr
virus driven tumours by targeting the virus
itself.
KWF-VU-2012-4555
€ 250.000
Middeldorp JM, Woulfe J
EBV and Parkinson Disease
Univ. Ottawa
Morré S, Lanjouw E (PSI)
Chlamydia screening
RIVM Chlamydia
Reference Lab
€ 120.000
Morris M, Kramer G, v.d. Eertwegh,
Lammertsma, Moorselaar
FDHT project
research project grant
€ 374,706
Mostert S
Compliance with childhood cancer
treatment in Manado
SMALL Foundation
€ 750.000
€ 30.000
€ 3.328
Niessen FB, Butzelaar L
NBS
€ 100.000
Pegtel DM, de Jong, Zijlstra
CCA-VICI
€ 150.000
Pegtel DM, Middeldorp JM, Voskuyl
Rheumafonds
€ 230.000
€ 150.000
Pegtel M, Zijlstra JM, de Jong D
Circulating microvesicles for non-invasive
remission monitoring in Hodgkins
Lymphoma
CCA V-ICI
Peters GJ, Galvani E
Novel EGFR inhibitors
FIRC Fondazione
Italiana per la ricerca
sul cancro
Post-Doc
Reijneveld JC, Verheul HW,
Würdinger T, Sol N
Monitoring of response to EGFRvIIItargeted treatment in patients with
glioblastoma through blood profiling
Dutch Cancer Society
(KWF
Kankerbestrijding)
€ 539.000
Schuurhuis GJ
I. development of biomarker panel for
identification of AML stem cells with
emphasis on detection of leukemia stem
cell subsets in teh bone marrow; II.
Assessment of AML-MRD in peripheral
blood (PBMC)
Industry
Schuurhuis GJ, Ossenkoppele G
In vitro activity of Z4681A-IGNs in primary
AML
ImmunoGen, Inc
€ 54.713
In vitro activity of AMG330 in primary AML
Amgen, Inc
€ 71.726
The radiosensitizing effect of PI3K/mTOR
inhibition in human glioma is
circumvented via the MAPK pathway
Dutch Society for
Oncology / Rene
Vogels Foundation;
Dutch Cancer Society;
Sminia P, Haas-Kogan D, Stalpers
LJA, Franken NAP, Narayan RS
133.380 USD
€ 8.112
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 101
Project leader(s)
Type of funding,
grant, contract
Title project
Budget
dr. Hendrik Muller's
Vaderlandsch Fonds;
Stichting de Fundatie
van de Vrijvrouwe van
Renswoude
€ 105.000
Smit L, Ossenkoppele FG,
Schuurhuis GJ, Cloos J
Targeting leukemic (stem) cell growth in
acute myeloid leukemia by a small
molecule inhibitor against Porcupine,
LKG974
Novartis/Pharmaceutic
al research
te Riele H, Brakenhoff RH, van
Beusechem VW
Compensatory survival mechanisms in
head and neck cancer cells from Fanconi
anemia patients: novel targets for cancer
therapy
NKB VU 2013-5983
Tito Poli (Uni Parma), Brakenhoff
RH, van de Wiel M
OraMod
EC-FP7
van Beusechem VW, Leurs R,
Würdinger T, de Esch I
Towards novel anti-cancer drugs directed
against G-protein coupled receptors to
improve treatment of prostate, lung and
brain tumors
Stichting VUmc CCA
€ 221.801
van der Vliet HJ, de Gruijl TD,
Verheul HMW, Chondronasiou D
VHH based therapies for cancer
VUmc-CCA research
grant
€ 240,000
van der Vliet HJ, de Gruijl TD,
Zweegman S, Lameris R
Targeting of CD1d in Multiple Myeloma
AICR research grant
€ 210,000
van Die I
Modulation of inflammatory responses by
helminth glyans
NIH
€ 250.000
van Egmond M, van de Loosdrecht
AA, Bakema J
The more the merrier: Combining the
strengths of IgG monoclonal antibodies
(mAbs) and FcaRI targeting to improve
anti-CD20 therapy of B cell malignancies
Stichting CCA
van Elsland S, van Furth AM
Home-based adherence of tuberculous
meningitis treatment
Mr Willem Bakhuys
Roozeboom Stichting
€ 25.000
van Kooyk Y
GlycoTreat-Novel vaccine generation fot
the treatment of cancer
ERC Advanced339977
€ 2500K
van Schaardenburg D
Statins to prevent RA
Dutch Arthritis
Association
Verbakel WFAR, Dahele M, Sörnsen
de Koste J, van der Weide-Berkelaar
L
DTS
Varian Master
Research Agreement
€ 87.000
Verbakel WFAR, Dahele M, Tol J
Knowledge based planning
Varian Master
Research Agreement
€ 100.000
Verdonck-de Leeuw IM, Leemans
CR, van Nieuwenhuizen A, Jansen F
Netherlands Quality of Life and Biomedical
Cohort Studies _ Head and Neck Cancer
Grant
Vervloet MG, Nerodova
€ 1.2Me
€ 150
€ 230.000
€ 2.999.500
Innovation grant
nierstichting (NSN)
€ 100.000
Verweij CL
Personalized medicine in the treatment of
rheumatoid arthritis
Dutch Arthritis
Foundation
€ 500.000
Vis AN
Testosterone measurement at low ranges
Astellas
€ 200.000
Keuzehulp prostaatkanker: ontwikkeling
Ipsen
Keuzehulp prostaatkanker: implementatie
en effectiviteit
CZ zorgverzekeraar
Wesseling P, Ylstra B, van Thuijl H
Identification of clinically relevant genetic
aberrations in pediatric glioneuronal
tumors (GNTs).
Edli Foundation (CCA)
Witing S, Steenbergen R, Meijer C
Construction of a discriminatory,
Research grant KWF
€ 25.000
€ 100.000
€ 50.000
€ 471.000
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 102
Project leader(s)
Type of funding,
grant, contract
Budget
Confidential, not specified
Hubrecht Institute
€ 5.000
Bladder Ca NGS FFPE copy number
aberrations
Centro Nacional de
Investigaciones
Oncológicas: CNIO (ES)
€ 20.000
HNSCC NGS FFPE copy number
aberrations
University of California
- San Francisco UC-SF
(USA)
€ 78.000
Ovarian Ca NGS FFPE copy number
aberrations
Cambridge Research
Institute (UK)
NGS soil organisms
Vrije Universiteit (VU),
Dept. Ecology
Title project
biologically relevant miRNA marker panel
for triage in hrHPV-based cervical cancer
screening
Ylstra B
Determine copy number aberrations in RET Universidade do Minho
syndrome patients
(PT)
€ 5.000
€ 20.000
€ 5.000
Neuroblastoma NGS FFPE copy number
aberrations
Academisch Medisch
centrum: AMC (NL)
€ 15.300
Salivary gland tumors FFPE arrayCGH
University of
Campinas: UNICAMP
(Brazil)
€ 15.000
NGS, Chromatin Structures
University of Edinburg
(UK)
€ 16.000
Ylstra B, Sie D
NGS translocations
Cergentis (NL)
€ 30.000
Zijlstra J, Zweegman S, van Dongen
G, Hoekstra O
Individualized therapy guided by immunopositron emission tomography.
a 3 year-Dutch Cancer
Society
grant
for
residents (KWF)
€ 270.000
Zijlstra JM, Jauw Y, van Dongen
GAMS, Hoekstra OS
Immuno-PET in obinutuzumb
Roche
€ 336.750
KWF grant
€ 400.000
Zweegman S
€ 1.600.000
Zweegman S, Abildgaard N
the trial “Randomized phase II trial in
newly diagnosed patients not eligible for
autologous stem cell transplantation,
comparing MLN9708 maintenance therapy
with placebo following induction with
MLN9708 – Thalidomide – low dose
dexamethasone” and for correlative
biological and imaging studies
Support
for
investigator initiated
study, Industrie
Zweegman S, Sonneveld P, van de
Donk N
the trial “ Feasibility and efficacy of dose
adjusted Melphalan – Prednisone –
Bortezomib (MPV) in elderly patients ≥ 75
years with newly diagnosed Multiple
Myeloma; a non-randomised phase II
study” and for correlative biological and
imaging studies
Support for
investigator initiated
study, Industry
€ 950.000
Zweegman S, Zijlstra JM, Jauw Y,
van Dongen GAMS, Hoekstra OS
Individualized therapy guided by immunoPET
KWF
€ 268.408
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 103
Meeting organization
Associate
Meeting
Place / date
Abbink, FCH
Landelijke SKION dag shared care
Amsterdam, NL, 15-11-2013
(Na)-scholing kinderoncologie, verpleging (shared care)
Amsterdam, NL, 11/13-32013
Ang, CW
2nd Course Infectious Disease Serology “The Hidden
Gold” (het verborgen goud)
Amsterdam, NL, 12/14-112013
Beelen RHJ
euRoPD
Maastricht, NL, 13-10-2013
Beliën, JAM
Seminar De uitdaging van het delen van medische
onderzoeksdata (3)
Utrecht, NL ,15-5-2013
Boellaard, R
Precongress Symposium EANM
Lyon, FR, 19-10-2013
Boers, M
12th OMERACT International consensus conference
Budapest, HU, 5-2013
Carvalho, B
OOA course on Early detection of cancer – Molecular
tools and new developments.
Amsterdam, NL, 9/10-122013
de Bree, R
Electrochemotherapy: A potential solution for
challenging situations in melanoma, breast cancer, and
head and neck cancer, Amsterdam
Amsterdam, NL, 1-2-2013
6th European Head & Neck Course, Amsterdam
Amsterdam, NL, 18/20-92013
de Gruijl, TD
Dutch Tumor Immunology Meeting
Breukelen, NL, 6/7-06-2013
Eerenstein, SEJ
6th European Head and neck course
Amsterdam, NL, 18-9-2013
1st European Head Neck Society "Make Sense" campaign Amsterdam, NL, 23-9-2013
Fijneman, RJA
Proteome analysis in translational research
Amsterdam, NL, 10-4-2013
Forouzanfar, T; Schulten, EAJM;
Baart, JA; Karagozoglu, KH
NVMKA voorjaarsvergadering
Amsterdam, NL, 31-5-2013
Wintersymposium Oral and Maxillofacial Surgery
Amsterdam, NL, 13-12-2013
Giovannetti, E
Chairman, Session “Pancreatic Development”, 45th
Annual Meeting of the of the European Pancreatic Club
(EPC-2013)
Zurich, CH ,28-06-2013
Chairman, Session “New Cancer Drug Targets”, Joint
34th EORTC-PAMM - BACR Winter Meeting
Cardiff, UK, 23-01-2013
Grunberg, K
OOA course
Amsterdam, NL, 30/31-12013
Heideman, DAM
Symposium ‘Moleculaire diagnostiek is vooruitzien’.
Utrecht, NL, 8-2-2013
OOA course "Early detection of cancer: molecular tools
and new developments"
Amsterdam, NL, 9/10-122013
Symposium ‘Moleculaire diagnostiek is vooruitzien’.
Utrecht, NL, 8-2-2013
OOA course "Early detection of cancer: molecular tools
and new developments"
Amsterdam, NL, 9/10-122013
Hulleman, E
KNAW symposium: "State of the art in diffuse intrinsic
pontine glioma"
Amsterdam, NL, 7/8/9-3-2013
Kaspers, GJL
Fourth Workshop on Pediatric Oncology
Eldoret, KE, 15/16-1-2013
KNAW symposium: "State of the art in diffuse intrinsic
pontine glioma"
Amsterdam, NL, 7/9-3-2013
Second Meeting European Pediatric AML Study Group
Amsterdam, NL, 2/3-10-2013
ESCMID-SHEA Course in Hospital Epidemiology
Potsdam, GE
Infectiepreventie voor AIOS medische microbiologu
Oisterwijk, NL
Leemans, CR
6th European Head and Neck Course
Amsterdam, NL, 18-9-2013
Meijer, CJLM
EEC Prehdict meeting
Amsterdam, NL, 10/11-42013
Eurogin (member scientific committee and chairman
session)
Florence, IT, 3/6-11-2013
Kluytmans, JAJW
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 104
Associate
Meeting
Place / date
EEC COHEAR kick-off meeting
Amsterdam, NL ,15/16-122013
4th European EBV Meeting
Amsterdam, NL, 17-6-2013
6th International Symposium on Nasopharyngeal
Carcinoma
Istanbul, TR, 20-6-2013
ECCMID 2011/2012/2013/2014
Barcelona, ES, 2011-2014
1st-9th AACM
Amsterdam, NL, 2005-2014
Chlamydia and HPV Screening
Vilnius, LT, 2011-
European Chlamydiae Meeting
Amsterdam, NL ,2012-
Nielsen, K
NanoKnife meeting
Amsterdam, NL, 24-10-2013
Peters, GJ
International Symposia on Purine and Pyrimidine
Metabolism in Man" (PPMM)
Madrid, ES, 6-2013
Middeldorp, JM
Morré, SA
European Organization for Research and Treatment of
Cancer (EORTC)
Winter EORTC-PAMM meeting
Cardiff, GB, 1-2013
25th EORTC-NCI-AACR congress on New Drug
Development
Boston, USA
EORTC Quality of Life Group Spring 2013 Meeting
Amsterdam, NL, 10/12-042013
EORTC Quality of Life Group Fall 2013 Workshop
Survivorship
Canterbury, GB, 11-9-2013
ESCD _immunology course
Amsterdam, NL, 13/15-32013
Dermatologendagen
Papendaal, NL, 11/12-4-2013
EECDRG
Odense, DK, 19/20-4-2013
Occupational and Environmental Exposure of Skin to
Chemicals (OEESC)
Amsterdam, NL, 2/5-6-2013
Refereeravond VUmc-AMC
Amsterdam, NL, 29-10-2013
MetaReview Dermatology 2013
Maarssen, NL, 31-10-2013
Contiunuum Dermatologica
Utrecht, NL, 12-12-2013
van Asseldonk, D
YICC
Utrecht, NL, 15-11-2013
van de Wiel, M
International Workshop on Statistical methods for (post) Genomics Data
Amsterdam, NL, 24/25-012013
Reijneveld, JC
Rustemeyer, T
van der Waal, I, Schulten, EAJM, European Meeting on Oral Diseases; diagnosis and
Brouns, EREA; van Steenbergen, management
TJM
Amsterdam, NL, 4/6-9-2013
Van der Waal, I
Mondpathologie. Een nascholingscursus voor de KNOartsen en dermatologen
Amsterdam, NL, 1-2-2013
van Grieken, NCT
Gastric cancer treatment. Anno 2013 and beyond.
Utrecht, NL, 10-4-2013
van Montfrans, C
Themadag Geneesmiddelenreacties Stichting
Nederlandstalige Nascholing voor Dermatologie en
Venereologie
Hasselt, BE, 20-4-2013
van Vuurden, DG
Internationale congres hooggradige Glioom
Amsterdam, NL, 5/6-3-2013
SIOP YC-MB HR meeting Amsterdam
Amsterdam, NL, 5-9-2013
HR Medulloblastoma Meeting
Amsterdam, NL, 5/6-11-2013
Vandenbroucke-Grauls, CMJE
Antibiotic resistance. An ecological perspective.
Amsterdam, NL, 5-3-2013
Verdonck-de Leeuw, IM
15th World Congress of Psyhco-Oncology and
Psychosocial Academy
Rottedam, NL, 4/8-11-2013
European Organisation for Research and Treatment of
Cancer, Quality of Life Group
Amsterdam, NL, 11/12-42013
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 105
Associate
Meeting
Place / date
Vis, AN
AMC - VUMC Urology Live
Amsterdam, NL, 1-1-2013
Wesseling, P
National Neuropathology Course for Residents in
Neurology
Utrecht, NL, Spring 2013
Neuropathology Course Eur. Soc. Pathology Meeting
2013
Lisboa, PT, 9-2013
EANM, CME "PET in oncology drug development"
Lyon, FR, 19-10-2013
ISRS, workshop Regulation of radiopharmaceuticals for
research use
Jeju, Korea, 12-5-2013
Zijlstra, JM
7th Dutch Hematology Congress
Papendal, NL, 23/25-01-2013
Zweegman, S
Chairman of the organizing committee of the fourth
Amsterdam Symposium Hematology - Intgraal
Kankercentrum Amsterdam
Amsterdam, NL, 1-11-2013
Windhorst, AD
Appendix Annual Report 2013 VUmc CCA – Indicators of esteem - 106
Appendix 6. Societal impact
Contributions, based on research, to post initial education
Associate
Topic
Audience
Date
Ang, CW
Lyme borreliose
2e Landelijke afweer en infectiedag
14-6-2013
Blauwhoff-Buskermolen, W
Undernutrition in cancer: Sarcopenia,
Cachexia and Wasting
Paramedics
13-6-2013
Bloemena, E
Cytology of salivary gland tumors
Aios Pathologie
29-1-2013
Wat is kanker
Tandartsen en mondzorgkundigen
5-4-2013
PET Pharmacokinetic course
NEURO/ONCO
Medical physicists / PET
researchers
11/13-9-2013
PET Pharmacokinetic course INMIND
Neuro PET researchers
25/27-11-2013
Eur.Fed.Of Med.Physics
summerschool
Medical physicists / PET
researchers
4/6-7-2013
ESTRO-EANM-ICIS course-"Molecular
imaging and dose painting in
Radiation
Radiation oncologists and
physicists
19-4-2013
Fontys themadag:Kwantificering
binnen de nucleaire geneeskunde
Nuclear medicine technologists
11-11-2-13
CTE session at EANM (Eur.Association
of Nuclear Medicine)
Nuclear medicine technologists
20-10-2013
Precongres symposium "Quantitative
Imaging and Dosimetry: Steps
towards Personalised Nuclear
Medicine Treatments"
Physicists, dosimetrists
19-10-2013
de Gruijl, TD
Tumor Immunology/immunotherapy
Research Nurses, Amstel
Academie, A'dam
21-1-2013
Grunberg, K
OOA course (organiser)
PhD students (VU/NKI/AMC)
30/31-1-2013
Heideman, DAM
Working group Lung Oncology,
NVALT (Dutch Association of Chest
Physicians), Lecture entitled
‘Molecular diagnostics: basic
principles.’
Chest physicians
March,
Terschelling, NL
OOA course "Early detection of
cancer: molecular tools and new
developments"
PhD students
9/10-12-2013
Symposium ‘Moleculaire diagnostiek
is vooruitzien’
Pathologist, residents in pathology,
KMBP(io), medical oncologists,
chest physicians
2-13, Utrecht, NL
Working group Lung Oncology,
NVALT (Dutch Association of Chest
Physicians), Lecture entitled
‘Molecular diagnostics: basic
principles.’
Chest physicians
March,
Terschelling, NL
OOA course "Early detection of
cancer: molecular tools and new
developments"
PhD students
9/10-12-2013
Symposium ‘Moleculaire diagnostiek
is vooruitzien’
Pathologist, residents in pathology,
KMBP(io), medical oncologists,
chest physicians
2-2013, Utrecht,
NL
Huisman, M
PET/CT user meeting
Clinical physicists
11-7-2013
Lammertsma, AA
Course organizer & tutor
INMiND Course PET Tracer
Pharmacokinitics and Data Analysis
Procedures
25/27-11-13,
Amsterdam, NL
Tutor
PET Pharmacokinitic Course
17/19-5-2013,
Boellaard, R
Appendix Annual Report 2013 Vumc CCA – Societal impact - 108
Associate
Topic
Audience
Date
Tutor
PET Farmacokinetiek 2013
11/13-9-2013,
Amsterdam, NL
Tutor
PRIMA IV workshop “Quantitative
Image analysis & application
specific imaging”,
22/26-9-2013,
Savannah
Tutor
INMiND Course PET and SPECT
Radiopharmaceuticals Preparation:
Design, Radiolabelling Strategy,
Radiosynthesis and Drug
Development
28/31-9-2013,
Amsterdam, NL
Radiobiological aspects Rapid Arc
Radiation Therapists
22-04-2013; 2504-2013; 05-062013
Tumor Radiobiology
Radiation Oncologists in training
7-10-2013
Radiobiology
MNW Bachelor students
18-06-2013; 1906-2013
Radiation and Chemical
Carcinogenesis
BMW Bachelor students
5-6-2013
Radiobiological aspects of VMAT
Oncology Scientists
22-11-2013
5Rs of Radiobiology and treatment
improvement
Master Oncology students
12-5-2013
Course grant writing
Medical Students
6-2013
Course Hematology
Medical Students
6- 2013
Shanghai
Sminia, S
Smit, L
Supervising Internships
Biomedical Science students
During the year
Steenbergen, R
Educational course on epigenetics
Teachers VWO Biology
4-4-2013
van der Laken, J
National MRI education
Rheumatologists
van der Sar, AM
Past, Present and Wish list for
Korvatunturi
Animal models II, 2013 part of
Infection and Immunity research
master, September 5
Summer master course,
international master students,
Erasmus, Rotterdam
9-3-2013
Mastercourse: Biomedical Systems
Biology, October
Master course, UVA, Amsterdam
16-10-2013
Mondziekten
Een nascholingscursus voor
mondhygiënisten NVM. Breukelen
15-3-2013
Oncologie voor de tandarts
Dentists
5-4-2013
Oncologie voor de mondhygiënist
Dental hygienists, NVM. Almere
4-10-2013
Diseases of the oral mucosa
Dental education ACTA, Dental
hygienists form Russia
3-5-2013
Histologie van gastrointestinale
poliepen
Pathologists
30-10-2013
Histopathologische respons op
therapie bij oesophaguscarcinoom
Chirurgen
4-7-2013
van Kooyk, Y
Tijdschrift IMMUUN
Voorzitter redactieraad
van Montfrans, C
Het ulcus cruris
Huisartsen en specialisten
ouderengeneeskunde
16-05-2013
Verbakel, WFAR
Introducing safely advanced
radiotherapy in Nepal
Oncologists, radiation oncologists
and medical physicists in Nepal
23-10-2013
Advanced radiotherapy imaging
radiation oncologists, medical
physicists in India
21-10-2013
Advanced radiotherapy imaging
Medical oncologists and radiation
oncologists in Liverpool, UK
26-6-2013
Van der Waal, I
van Grieken, NCT
Appendix Annual Report 2013 Vumc CCA – Societal impact - 109
Associate
Topic
Audience
Date
Yaqub, M
PET Pharmacokinetic course
NEURO/ONCO
Medical physicists / PET
researchers
11/13-9-2013
PET Pharmacokinetic course INMIND
Neuro PET researchers
25/27-11-2013
Replication Stress and Chromosomal
Instability (OOA course)
PhD students OOA
20-12-2013
Ylstra, B
Appendix Annual Report 2013 Vumc CCA – Societal impact - 110
Lectures for health care professionals, general public and patients
(non-scientific audience)
Associate
Topic
Audience
Date
Braamse, A
Psychosociale nazorg na
stamceltransplantatie
Oncologiedagen 2013: Vooruitzien
en grenzen verleggen
20-11-2013
Bultink, IEM
Systemische Lupus
Erythematosus
Patients
23-3-2013
Sports and rheumatic diseases
Health care professionals
11-10-2013
Ontwikkeling van een
moleculaire test voor de
detectie van colorectaal
kanker: ontlastingstest
MLDS
10-8-2013
Chromosome 20q
Amplification in Colorectal
Adenoma to Carcinoma
progression
Kreatech
3-8-2010
Carvalho, B
Dikke darmkanker:'Voorkomen Avanti
is beter dan genezen'
29-10-2009
My research at the VUmc, and
how to survive as a foreigner
in Amsterdam
Top Talent Program
19-05-2010; 19-052008
Chamuleau, M
M. Waldenstrom
Patientenvereniging
1-2-2013
Cloos, J
De rol van leukemische
stamcellen voor de
behandeling van acute
myeloide leukemie
Donateurs CCA
11-6-2013
VUmc Onderzoek naar
Kinderkanker; laboratorium
onderzoek
Donateurs VONK
30-5-2013
VUmc Onderzoek naar
Kinderkanker; laboratorium
onderzoek
Lions club
9-4-2013
de Gruijl, TD
Breast cancer research
Patients, A Sister's Hope
19-9-2013
Eeltink, C
Questionnaire for assessing
chemotherapy induced
neuropathy
EBMT nurses
8-4-2013
Quality of Life and the Monitor
Clinical Profile
Oncology nurses
19-11-2013
Sexual function in later life
Oncology nurses
19-11-2013
pathology of the salivary
glands
3rd year Bachelors Medicine Vumc
25-1-2013
Multimodal treatment in HNcancer
2nd year Bachelors Medicine Vumc
8-5-2013
Surgical treatment in HNcancer
Members of "samen leven met
kanker"group VUmc12-03-2013
Commando-resections in HN
cancer
Medical operation personel VUmc
3-6-2013
Fijneman, RJA
Colorectal cancer screening
Friends of the Cancer Center
Amsterdam
once or twice a year
Grunberg, K
Tissue procurement for
molecular diagnostics in lung
cancer
VAP postgraduate teaching
(Veldhuyzen) course
22-11-2013
CCLO Vancouver
Pulmonary physicians, physician
assistants, nurses
9-2-2013
Lung cancer
Residents pulmonary medicine
3-2013
Eerenstein, SEJ
Appendix Annual Report 2013 Vumc CCA – Societal impact - 111
Associate
Topic
Audience
Date
Mooi, WJ
E-learning Event 2013
General, ICT professionals,
teachers
16-4-2013
Oprea-Lager, DE
Performances of Ingenuity TF
PET/MRI
Health care professionals
(Radiologists, NM physicians,
Physicists)
27-5-2013
The case of the month
Health care professionals (Nuclear
medicine Physicians, Physicists)
14-10-2013
Imaging prostate cancer with
choline
Health care professionals
(Urologists and Oncologists)
5-2-2013
18F-choline PET/CT in
prostate cancer
Health care professionals
(Radiologists)
12-2-2013
PET/CT and PET/MRI in
prostate cancerHealth care
professionals (Urologists,
radiologists, NM physicians
and Oncologists)
Health care professionals
(Urologists and Oncologists)
4-6-2013
Postma, TJ
neuro-oncology
Data management, general public';
IKNL
27 09 2013
Reijneveld, JC
Samenwerking tussen
disciplines in een neurooncologisch zorgpad.
Congres 'Organisatie van
oncologische zorg', UMC Utrecht
(health care professionals)
23-5-2013
Neuro-oncologie
(dagvoorzitter)
Publieksdag Hersentumoren,
Maarssen (patiënten en naasten)
16-3-2013
Scheper, RJ
Contact allergy from a dental
perspective
Dentists, trainees; Jember,
Indonesia
11-10-2013
Smit, L
Beroepenmarkt/Barleas
Gymnasium
Scholieren Gymnasium 3-6
28-1-2013
Snijders, PJF
De rol van
methyleringsmarkers in het
bevolkingsonderzoek
baarmoederhalskanker
Werkgroep Cervix uteri, Utrecht
(health care professionals)
24-6-2013
Early detection/screening of
cancer
Master students Amsterdam
University College
21-10-2013
Cervical cancer screening
program: towards full
molecular screening
AIOs (OOA course 'Early detection
of cancer – Molecular tools and
new developments')
9-12-2013
Taphoorn, MJB
Cognitieve gevolgen van het
glioom
Landelijke nascholing Nederlandse
Vereniging Neurochirurgie
Assistenten
24-5-2013
van Dulmen-den Broeder, E
En Later? Over vruchtbaarheid
childhood cancer survivors and
their families
9-3-2013
En Later? Over vruchtbaarheid
Childhood cancer survivors and
their families
12-10-2013
van Egmond, M
New insights in the pathology
of Dermatitis Herpetiformis’
Belgian Celiac Disease Day
(Keerbergen; patients)
3-9-2013
Verdonck-de Leeuw, IM
Quality of life and
psychosocial care
Nurses
19-11-2013
eHealth and oncology
Health care professionals
3-10-2013
Depression and cancer
Psychologists and other
professionals
26-9-2013
Quality of ife
Patient society testis cancer
25-9-2013
Care innovation
(Health care) profesionals
20-9-2013
Quality of life, eHealth
General public
9-3-2013
Progress in Brain Tumor
Research
National information day for brain
cancer patients and their relatives;
Maarssen/Utrecht
Spring 2013
Wesseling, P
Appendix Annual Report 2013 Vumc CCA – Societal impact - 112
Associate
Topic
Audience
Date
Wintzen, M
Huidafwijkingen bij ouderen
Verpleeghuisartsen i.o.
13-3-2013
Ylstra, B
Oratie: Kanker is een ziekte
van het genoom: wat anders!?
General public
27-11-2013
Wetenschappelijk focus
onderwijs (WFO)
Health care professionals
10-6-2013
Zijlstra, JM
Wait and see policies in
lymphoma
Patients
2-3-2013
Zweegman, S
Highlights of ASH
Myeloma Patients Europe
31-1-2014
Appendix Annual Report 2013 Vumc CCA – Societal impact - 113
Memberships of an advice council in the public/commercial field
Associate
Name advice council
Position/function
Public/commercial
Beelen RHJ
Zytoprotec council
Advisor
Commercial
Bitter, W
NVMM
Member scientific committee
Public
Bultink, IEM
Medical Advice Council of the
'Nationale Vereniging voor lupus,
sclerodermie en MCTD patienten'
(NVLE)
Member
Public
Local patient department of the
Dutch Arthritis Foundation (Reuma
patientenvereniging Amstelland en
omstreken)
Medical advisor
Public
Dutch network for Patient Research
Partners in Rheumatology
Member of steering committee
Public
CBG
Advisor
Public
Roche
Advisor
Commercial
de Gruijl, TD
DCPrime BV Scientific Advisory
Board
Member
Commercial
Eeltink, C
Lymfoom Vereninging Nederland
Member
Public
Grunberg, K
Dutch Lung Association (longfonds)
Scientific advisory board
Public
Kluytmans, JAJW
Amphia Ziekenhuis
Breda/Oosterhout
Consultant Microbiologist and
Head of the Dep. Of Inf. Control
Commercial
St. Elisabeth Ziekenhuis Tilburg
Consultant Microbiologist and
supervisor education medical
microbiology
Commercial
TweeSteden Ziekenhui Tilburg
Consultant Microbiologist
Commercial
Vumc
Prof. of Medical Microbiology
and Infectioncontrol
Public
National Working Party on Infection
Control (WIP)
Chairman
Public
Infection Control Committee
Amphia Ziekenhuis,
Breda/Oosterhout
Chairman
Public
Nederlandse Vereniging voor
Medische Microbiologie
Chairman
Public
NVMM guideline committee:
detection of Highly Resistant
Chairman
Public
Verpleeghuis Elisabeth, Breda
Member Infection Control
Committee
Public
Amphia Ziekenhuis
Breda/Oosterhout
Member Committee promoting
science
Public
Concilium Microbiologicum Medical
Microbiology
Member
Public
Publications Committee SHEA
Member
Public
European Advisory Board 3FM
Member
Public
Int. Steering Committee
Staphyloccus aureus vaccine Pfizer
Member
Public
ZIEN
Founder and member
Public
European Course on Hospital
Epidemiology and Infection Control
Chairman and member faculty
Public
Chamuleau, M
ASM conference Emerging
CO-organizer
Technologies of Medical Importance
for the Diagnosis of Infectious
Diseases and the Detection of
Public
Appendix Annual Report 2013 Vumc CCA – Societal impact - 114
Associate
Name advice council
Position/function
Public/commercial
Society for Healtcare Epidemiology
of America (SHEA)
Fellow
Public
Fellow
The Royal College of Physicians
of Edinburgh (RCPE)
Public
Genalice BV
Member Advisory Board
Commercial
Merck Serono
Member Scientific Advisory
Board mCRC
Commercial
MDXHealth
Member Scientific Advisory
Board
Commercial
ACHMEA
Member expertpanel moleculaire
diagnostiek
Public
Cyto-Barr BV
Founder and CEO
Commercial
Argen-X
Consultant
Commercial
CSI
Advisory Board member
Public
ECCMID
Review Board
Public
Scheper, RJ
Scientific Board DC-Prime BV,
Leiden
member
commercial
Snijders, PJF
Sub-committee HPV of the
Member
Workgroup Molecular Diagnostics in
Pathology (WMDP)
Public
van Beusechem, VW
Medicines Evaluation Board expert
group on Advanced Therapy
Medicinal Products
Member
Public
Vandenbroucke-Grauls,
CMJE
Adviescommissie Centrum voor
Infectieziektenbestrijding van het
RIVM
Chairman
Public
Programmacommissie
Infectieziektenbestrijding van
ZonMw
Member
Public
TOP commissie ZonMw
Member
Public
Registratiecommissie ISIS, Centrum
voor Infectieziektenbestrijding van
het RIVM
Chairman
Public
Programmacommissie
Antimicrobiële Resistentie van
ZonMW
Member
Public
NWO, |TOP commissie
Member
Public
Bestuur Nederlandse Vereniging
voor Medische Microbiologie
Member
Public
Antonie van Leeuwenhoekstichting
Member
Public
Commissie Wetenschap Sint Lucas
Andreas Ziekenhuis
Member
Public
European Comission, FP7-HEALTH2011-single-stage
Evaluator
Public
Verbakel, WFAR
Knowledge Based Planning
Council member
Commercial
Vis, AN
Abbvie
Commercial
GSK
Commercial
Pathogenic Microbes
Meijer, GA
Middeldorp, JM
Morré, SA
Wesseling, P
Wintzen, M
STOPbraintumors Foundation
Member Scientific Advisory
Board
Public
Koppie-AU Foundation
Member Scientific Advisory
Board
Public
College ter Beoordeling van
Consultant
Public
Appendix Annual Report 2013 Vumc CCA – Societal impact - 115
Associate
Name advice council
Position/function
Public/commercial
Medische Advies Raad Hematon
patientenvereniging
Member
Public
Advisory boards of Celgene,
Millennium, Janssen, Novartis
Member
Commercial
Geneesmiddelen
Zweegman, S
Appendix Annual Report 2013 Vumc CCA – Societal impact - 116
Perceptible impact on public informing and/or authoritative websites
Associate
Website
Description
Beelen RHJ
www.eutripd.eu
Website eutripd
Beliën, JAM
www.ctmm-trait.nl
Website dedicated to Sustainable
infrastructure for medical
research projects
de Gruijl, TD
Tumor
Immunology/immunotherapy
Research Nurses, Amstel
Academie, A'dam
Eerenstein, SEJ
www.makesensecampaign.eu
Dutch webpages for
international website on head
neck cancer
www.hoofd-halskanker.nl
Dutch website on risk
factors/treatment HNcancer
Type of information
Collaborating partners
www.hoofd-halskanker.com
http://www.vumc.nl/afdelinge
n/themakanker/soorten_kanker/soort/
hoofdhalstumoren-alg
Grunberg, K
www.pathology.nl
Dutch Scientific Society for
Pathology (NVVP)
Collaborating partners
Moll A
www.retinoblastoom.nl
the Dutch retinoblastoma center
website
Health information
Mooi, WJ
www.melanocyticpathology.co
m
Educative website (postgraduate)
Morré, SA
www.immunogenetics.nl
Laboratory of Immunogenetics
Collaborating partners
www.GRaPHInt.org
Public Health Genomics
Health information
www.EpiGenChlamydia.com
EU FP project based website
Collaborating partners
http://a-skin.nl/
Texts on novel skin ulcer
treatments
Health information
http://www.dcprime.nl/
Texts on novel tumor vaccines
Health information
http://www.vumc.nl/afdelinge
n/kinderoncologiehematologie/onderzoek/lateeffecten-onderzoek/VEVOonderzoek/
Provides information about the
background, aims and progress
of the DCOG-LATER VEVO Study
on reproductive function and
risk of premature menopause in
female childhood cancer
survivors
Research project
https://www.skion.nl/voorpatienten-en-ouders/lateeffecten/530/zorg/
Provides information for patients
and their parents on the late
effects of childhood cancer
Health information
http://www.skionlaterstudie.nl
/
Provides information about
currently ongoing large scale
nationwide DCOG-LATER Study
www.samenlevenmetkanker.nl
Provides information on research Collaborating partners
of the research group "Living
with cancer"
www.triple-ehealth.nl
Information on eHealth projects
VU, Vumc, GGZ Ingeest
Collaborating partners
www. Oncokompas.nl
Public website on the
OncoKompas
Collaborating partners
www.polaris-study.org
Information on POLARIS project
Collaborating partners
www.kubusproject.nl
Information on NET-QUBIC
project
Collaborating partners
www.halszaken-vumc.nl
Intervention targeting exercises,
head and neck cancer patients
Health information
Scheper, RJ
van Dulmen-den Broeder, E
Verdonck-de Leeuw, IM
Appendix Annual Report 2013 Vumc CCA – Societal impact - 117
Associate
Ylstra, B
Zijlstra, JM
Website
Description
Type of information
www.hoofdzaken-vumc.nl
Intervention targeting
psychological distress in head
and neck cancer patients
Health information
www.verderzonderstembanden Intervention targeting
.nl
laryngectomized patients
Health information
http://www.sciencepalooza.nl/ Public informing
author/terry/?s=
Research project
http://www.diagned.nl/nieuws
-endocumentatie/nieuws/berichte
n/kankermedicijn-wordtmaatwerk.html
Public informing
Health information
www.hovon.nl
Information concerning
treatment lymphoma
Health information
Appendix Annual Report 2013 Vumc CCA – Societal impact - 118
Patent applications, spin-off and start-ups
Author(s)
Name
Number
Date assigned
Bosch LJW, de Wit M, Pinto
Morais de Carvalho B,
Fijneman RJA, Meijer GA,
Jimenez CR, Piersma SR,
Pham VT, Oudgenoeg G
Biomarkers - Protein biomarkers for
CRC early detection
WO/2013/162368
26-4-2013
Houthoff, HJ, van Dongen
GAMS, Kok RJ, Waalboer
DCJ, Buwalda SJ, Sijbrandi
NJ
Method for preparing cell targeting
complexes, and the complexes
obtained
WO2013103301 A3
4-1-2013
Schuurhuis GJ, Zeijlemaker
W, Ossenkoppele GJ
Leukemic stem cell markers description of one tube containing
antibody-fluorochrome
combinations that allow to assess
leukemia stem cells in AML
2011904
6-12-2013
van Wetering S, de Gruijl
TD, Kruisbeek AM, van de
Ven R, Scheper RJ
Method for inducing and
accelerating cells
US8,470,789B2
25-6-2013
Appendix Annual Report 2013 Vumc CCA – Societal impact - 119
Contributions a directive, protocol, or policy note
Author(s)/name researcher(s)
Title/topic
Committee
Blaauwgeers, Grunberg
NVVP beleidsplan 2014-2018
Board Dutch scientific society for
pathology (NVVP)
Boellaard, R
Aanbevelingen nucleaire geneeskunde,
hoofdstuk apparatuur, pet/ct
NVNG kwaliteitscommissie
Brakenhoff, RH
Website Fanconia anemie
Brandsma D et al
National Guideline meningiomas
Bromberg J et al
National Guideline CNS germ cell tumors Member of LWNO committee
in adults
de Man, RA, Bloemena E, van den
Bosch MA, van Delden OM, v Erpecum
K, Eskens F, Jansen PLM, de Jong KP,
Klümpen H, Kleijwegt T, Koerts G,
Mendez Romero A, Verheij J, Verhoef
C.
Landelijke richtlijn hepatocellulair
carcinoom
Landelijke werkgroep Gastrointestinale
tumoren
Gijtenbeek JM et al
National Guidelines Quality Criteria in
Clinical Neuro-Oncology
Member of LWNO committee
Member of LWNO committee
Hastings, R.; R. Vanni; N. Bown; D.
Best Practice Tumour Guidelines
Betts; S. Chatters; S. Heim; Z. Zuzana;
E van den Berg-de Ruiter; B. Espinet; M.
Biletti; A. Bernheim; N. van Roy; B.
Ylstra; M. Salido Galeote; P. Roberts;
M. Teixeir; M. Stevens-Kroef; J.
Schoumans-Pouw; A. Simons; G.
Cheryl; B. Carleer; V. van Spauwen; B.
Dewaele
EU: EuroGentest
Hulleman, E
Discipline group molecular research
SKION commissies
Leemans, CR, Bloemena E, Langendijk
J, Pameijer F, van Erpen C, et al
Landelijke richtlijn hoofd hals carcinoom NWHHT
Maessen-Visch, MB , K. van der Wegen- Diagnostiek en behandeling van het
Franken , H.A.M. Neumann , A.B. Halk, ulcus cruris venosum
C. Eggen,. J.J.E. van Everdingen, C. van
Montfrans, P. van Neer, K. Munte, L.
Huisman, A. Krasznai, P. Buis, M.W.F.
van Leen, E.J.M. Kuijper-Kuip, S.
Amesz, Y. Siebers, T. Jongerius, I.
Sissingh, C. von Meijenfeldt
Dutch guideline working group venous
leg ulcer
Minnema, M, UMCU, Marijke Eurelings,
Spaarne ziekenhuis, Corien Eeltink,
Vumc
A web-based medical device , Monitor
Clinical Profile
Minnema, MC, Hazenberg BP,
Croockewit A, Zweegman S, Kersten
MJ, Sonneveld P, von dem Borne PA,
Bos G, van de Waal E, Vellenga E,
Lokhorst HM
De behandeling van AL amyloidose in
Nederland
MWG HOVON
Morré, SA
Chlamydia Screening
RIVM
Chlamydia Screening
European CDC
Mostert, S
Abandonment of Treatment Working
Group
SIOP PODC
Siersema P, …, van Grieken, et al
Dutch clinical guideline on Esophageal
cancer
IKNL
Van de Beek, van Furth AM et al
Bacteriele meningitis
CBO richtlijn
van Dorp, W, van Dulmen-den Broeder
E., van den Berg M., van den HeuvelEibrink M.M., Dilorgio N., Levine J,
Mulder R., Kremer L.C.M., Hudson M.,
Haupt R.,Wallace W.H. (order to be
Female Guideline on female
gonadotoxicity surveillance
International Guidelines Harmonisation
Group
31 item Chemotherapy Induced
Peripheral Neuropathy Questionnaire
Appendix Annual Report 2013 Vumc CCA – Societal impact - 120
Author(s)/name researcher(s)
Title/topic
Committee
van Veldhuizen, H, van Wieren M, Olde
Reuver of Briel A, Nagtegaal I, Kliffen
M, Bloemena E, Brouwer E
Kwaliteitseisen Pathologie in het kader
van het Bevolkingsonderzoek
Darmkankerscreening
RIVM
Vos, JM, Minnema MC, Wijermans PW,
Croockewit S, Chamuleau ME, Pals ST,
Klein SK, Delforge M, van Imhoff GW,
Kersten MJ; HOVON Multiple Myeloma
Working Party; HOVON Lymphoma
Working Party
Guideline for diagnosis and treatment of Neth J Med. 2013 Mar;71(2):54-62.
Waldenström's macroglobulinaemia
Zweegman, S et al
Richtlijn behandeling Multipel Myeloom
determined, in preparation)
MWG HOVON
Appendix Annual Report 2013 Vumc CCA – Societal impact - 121
Media attention
Associate
Topic
Medium
Name source
URL
Braakhuis, BJM
Interview- Researcher of
the week+
Other online sources
(weblog, newsfeed,
newsletter)
KWF face book-page, 1012-2013
https://www.facebook.
com/KWFKankerbestrij
ding?hq_e=el&hq_m=5
7612&hq_l=16&hq_v=
2c85fcd58a
Bultink, IEM
Paget's disease
Magazine
RondReuma magazine,
March 2013
http://www.reumafond
s.nl/
Osteoporosis
Magazine
RondReuma magazine,
June 2013
http://www.reumafond
s.nl/
Juvenile idiopathic
arthritis
Magazine
RondReuma magazine, 1- http://www.reumafond
9-2013
s.nl/
Sarcoidosis
Magazine
RondReuma magazine, 1- http://www.reumafond
12-2013
s.nl/
Chamuleau, M
Burkitt lymfoom
Magazine (online/print)
Hematology News
De Gruijl, T
Een nieuw vaccin tegen
leukemie
Magazine (online/print)
Mediator (NWO), 1-122013
http://mediator.zonm
w.nl/mediator-3december2013/vaccin-in-demaak-tegen-acuteleukemie/
Douw, L
Paper in NeuroImage
Other online sources
(weblog, newsfeed,
newsletter)
EANO website, 6-1-2013
www.eano.eu
Paper in Radiology
Other online sources
(weblog, newsfeed,
newsletter)
Martinos center website,
19-11-2013
http://www.nmr.mgh.
harvard.edu/news/131
119/epilepsy-patientsexhibit-altered-brainconnections
Paper in NeuroOncology
Newspaper (online)
News Daily, 9-6-2013
http://www.newsdaily.
com/health/8f4adb97
afc5a4e21c2d89da203
95db7/modafinil-failsto-ease-brain-tumorrelated-symptoms
Paper in NeuroOncology
Other online sources
(weblog, newsfeed,
newsletter)
The Doctors Channel, 94-2013
http://www.thedoctors
channel.com/view/mo
dafinil-fails-to-easebrain-tumor-relatedsymptoms/collection/r
euters/
Inspiring women election
Magazine (online/print)
Viva, 10-1-2013
http://www.viva.nl/ste
m-wedstrijdonderdeel/linda-douw
Gibbs, S
Tegen die tijd zullen we
zeker in staat zijn om
zweren, beenwonden en
doorligplekken te
genezen die nu soms
jarenlang openblijven of
zelfs helemaal niet
herstellen
Newspaper
Trouw, 11 maart
Giovannetti, E
Buitengaats' (rubriek over Magazine (online/print)
onderzoekers over de
grens) Dr. Elisa
Giovannetti
Mediator (Magazine
ZonMw), 8-1-2013
Heideman, DAM
Interview Heideman
DAM. Snelle test
beschikbaar om tumoren
mee te karakteriseren.
Tracer, December 2013
Tracer
http://mediator.zonm
w.nl/mediator-1augustus-2013/innederland-is-allesgoed-georganiseerd/
Appendix Annual Report 2013 Vumc CCA – Societal impact - 122
Associate
Topic
Medium
Name source
Heidemans,
DAM and
Snijders, PJF
Pathologen specialiseren
zich in moleculaire
biologie
Tracer
Tracer, September 2013
Horrevoets, A
In elk chromosoom zitten Radio
telomeren ingebouwd, en
naarmate je ouder wordt
worden die steeds korter.
Op een gegeven moment
zijn ze zo kort dat dat
ervoor zorgt dat het DNA
niet meer goed
functioneert en zo’n cel
een soort
geprogrammeerde
celdood ingaat
Labyrint, VPRO, Radio 1
(24-2-2013)
Huijgens, PC
Je moet een patiënt met
kanker blijven zien als
een mens met alles wat
daarbij hoort; een hart,
longen en weet ik wat
meer. En niet als een
kanker waar een patiënt
omheen zit
Magazine
Medisch Contact, May
2013
Je moet een heel goed
team hebben dat een
patiënt echt door de
ziekte sleept, door de
infecties en de
bloedingen. Er lopen
hier veertig
verpleegkundigen rond,
tien hematologen, we
hebben de bloedbank,
het laboratorium. Er zit
hier een hele club en die
patiënt zit als het ware
ingepakt in een cocon –
zo trekken we hem
erdoor
Magazine
Elsevier, September 2013
Ik vind het onzinnig als
wordt gezegd:
‘gezondheidszorg kost
veel geld’. Nee, we geven
er geld aan uit, net als
aan huisvesting,
onderwijs of
infrastructuur
Newspaper (print)
Parool, 15-10-2013
Proteomics voor vroege
detectie darmkanker
Magazine (online/print)
Oncologie Up-to-date, vol
4: 6, December 2013
Jimenez, CR
Kaspers, GJL
Tandem-MS brengt ziekte Magazine (online/print)
in kaart: Met
geavanceerde MStechnieken zoekt het
Amsterdamse
OncoProteomics
Laboratory naar
biomarkers
C2W Life Sciences, 26-42013
Cancer
Television
Sta op tegen Kanker,
March 2013
Het
overlevingspercentage
onder kinderen die voor
de tweede keer AML
krijgen, is in 20 jaar
gestegen van 16 naar 36
procent. Daardoor
Internet
NOS journaal
URL
nos.nl
Appendix Annual Report 2013 Vumc CCA – Societal impact - 123
Associate
Topic
Medium
Name source
URL
overleven in Europa
jaarlijks tientallen
kinderen meer
Kluytmans, J
Wie in aanraking komt
met ESBL wordt niet
direct ziek, maar de
bacterie kan zich wel in
het lichaam nestelen en
grote schade
veroorzaken. De bacterie
kan bijvoorbeeld voor
een blaasontsteking
zorgen en antibiotica
helpen dan niet
Newspaper
De Telegraaf, 24-5-2013
Krekel, N
Het gaat om de categorie
voelbare tumoren in de
borst. Chirurgen
opereren dan meestal op
gevoel en halen vaak een
behoorlijk stuk weg, ook
gezond weefsel. … Bij
gebruik van de echo was
de hoeveelheid
verwijderd weefsel
precies goed
Newspaper (print)
De Telegraaf
Waar met de traditionele
methode 1 op de 5
tumoren er niet in een
keer uit was, waardoor
die vrouwen opnieuw
behandeld moeten
worden, daarbij is dat bij
echogeleide
borstchirurgie maar 1 op
de 30. Dus dat is een
enorme verbetering
Television
De Wereld leert door (62-2013)
Momenteel is dat nog 30
procent, maar orale seks
kan weleens de grootste
veroorzaker van
keelkanker worden
Television
RTL Editie NL (4-2-2013)
Make Sense Campaign
Newspaper (print)
De Telegraaf, 1-9-2013
Make Sense Campaign
Newspaper (print)
Financieel Dagblad
(bijlage), 1-9-2013
Make Sense Campaign
Newspaper (online)
De Telegraaf, 27-9-2013
Mebius, R
Een directe link tussen
ziekteverwekkende
bacteriestammen en
ziekten is niet eenvoudig
te leggen, maar het lijkt
er wel sterk op dat een
gevarieerd
samengestelde darmflora
beschermt tegen het
innestelen van
schimmels, bacteriën en
virussen. Voeding is dus
belangrijk voor het
immuunsysteem en de
gezondheid in het
algemeen
Magazine
Immuun, June 2013
Meijer, CJLM
HPV vaccination
Radio
NOS journaal, 11- 5-2013 http://nos.nl/video/50
5697-wat-doe-ik-haaraan.html
Nieuwe vorm BVO
Television
RTL nieuws, 18-10-2013
Leemans, CR
http://www.hebikietsg
Appendix Annual Report 2013 Vumc CCA – Societal impact - 124
Associate
Topic
Medium
Name source
baarmoederhalskanker
dmv HPV zelfafnametest
Meijer, GA
Mulder, C
URL
emist.nl/aflevering/16
8040/rtl-4/rtlnieuws/19-30-uur.html
Wie van de drie,
Baarmoederhals
screening
Magazine
Elsevier, 14-10-2013
DNA test beschermt
beter dan het uitstrijkje
Newspaper
Volkskrant, 3-11-2013
HPV test voorkomt fors
meer kanker dan het
uitstrijkje
Newspaper
NRC, 4-11-2013
DNA test beter dan het
uitstrijkje
Newspaper
Gooi en eemlander, Leids
dagblad, 4-11-2013
DNA test beter dan het
uitstrijkje
Newspaper
Telegraaf, 4-11-2013
Bevolkingsonderzoek
Darmkanker
Magazine (online/print)
ZonMW Nieuwsbrief, 273-2013
Bevolkingsonderzoek
Darmkanker
Magazine (online/print)
Nieuwsbrief Vumc CCA,
1-3-2013
Epigenetic Marker as
Companion Diagnostic….
Other online sources
(weblog, newsfeed,
newsletter)
Persbericht MdXHealth,
3-6-2013
Maintaining close
relationships
Magazine (online/print)
Inter Faces, 1-4-2013
Vroege opsporing
darmkanker
Magazine (online/print)
Leaflet MLDS, 1-11-2013
Moleculaire
karakterisering van nonpolypoide colorectale
adenomen
Magazine (online/print)
Oncology news
international, 22-122013
In Nederland kregen
mensen in 1998
gemiddeld 13 gram
gluten per dag binnen.
Nu is dat 18 gram. Er
moet wel een relatie zijn
met het feit dat het
aantal mensen met
coeliakie toeneemt. Maar
hoe het precies zit,
weten we niet
Newspaper (print)
NRC, 9-11-2013
Er zijn steeds meer
patiënten die na testen
geen coeliakie blijken te
hebben, maar toch geen
gluten verdragen
(buikpijn, moe). Bij 8 à 9
van de 10 mensen met
non-coeliac gluten
sensitivity vinden we
geen oorzaak
Newspaper (print)
NRC Next, 14-11-2013
Penninx, B
Stress heeft zeker effect
Television
op ons immuunsysteem.
Dat zien wij ook in ons
eigen onderzoek waarin
we kijken naar depressieen angstpatiënten. Die
ervaren chronische stress
en daarbij zien wij ook
dat het immuunsysteem
overgeactiveerd is
Labyrint, VPRO/NTR,
Nederland 2, 14-4-2013
Reijneveld, JC
Memory problems in
Medisch Contact, 18-12-
Magazine (online/print)
http://medischcontact.
Appendix Annual Report 2013 Vumc CCA – Societal impact - 125
Associate
Topic
Medium
brain tumour patients
Name source
URL
2013
artsennet.nl/home.ht
m
Rietbergen, M
Ongeveer 550 mensen
krijgen jaarlijks
keelkanker en het komt
bij mannen driemaal
zoveel voor
Magazine (print)
Spits, 4-4-2013
Scherpenisse, M
Tussen 1996 en 2007
steeg het aantal HPVinfecties van 20 naar 23
procent van de
onderzochte personen
Newpaper (print)
Reformatorisch Dagblad,
18-10-2013
Slotman, B
We hebben tegen elkaar
gezegd: als we het
samen doen, is het
vrijwel zeker – door alle
expertise die we
bundelen – dat we het
kunnen opzetten
Newspaper (print)
Parool, 6-7-2013
We verwachten dat we
sommige patiënten een
hogere stralingsdosis
kunnen geven, omdat de
bijwerkingen minder
zijn. Dat betekent dat de
kansen op genezing
kunnen stijgen
Newspaper (print)
Trouw, 2-8-2013
KMBP
Other online sources
(weblog, newsfeed,
newsletter)
Tracer (number 19) , 199-2013
http://issuu.com/vum
c/docs/tracer_19__low
res_?e=2286190/4899
672
Citations HPV papers
Other online sources
(weblog, newsfeed,
newsletter)
Tracer (number 25), 1212-2013
http://issuu.com/vum
c/docs/tracer_25_lowr
es?e=2286190/59812
16
Stoop, E
Door een voor een
factoren uit te schakelen
in de bacterie, hebben
we onderzocht welke
factoren belangrijk zijn
voor het ziekteproces.
Dit heeft geleid tot de
identifi catie van 23
factoren die de bacterie
nodig heeft om de ziekte
te veroorzaken
Newspaper
Nederlands Dagblad (233-2013)
VandenbrouckeGrauls, C
Elke huisarts dringt erop
aan: “maak een
antibioticakuur af”. De
achterliggende gedachte
is dat ziekmakende
bacteriën resistent
worden als zij een (te
korte) antibioticakuur
overleven. Dat is
pertinent niet waar
Newspaper
Noordhollands Dagblad,
13-3-2013
Van Dongen,
GAMS
Als we zien dat een
medicijn een tumor niet
bereikt, kunnen we
meteen een ander
proberen. Daarnaast
kunnen we sneller zien
of een behandeling
aanslaat en ook de
dosering van de
Magazine (print)
Esta (January)
Snijders, PJF
Appendix Annual Report 2013 Vumc CCA – Societal impact - 126
Associate
Topic
Medium
Name source
URL
Magazine (online/print)
Arts en Auto Student, 198-2013
http://www.artsenauto
.nl/beroep-onder-deloep-klinischpatholoog/
medicatie op de persoon
afstemmen. Behalve
tijd scheelt dat voor
patiënten een hoop nare
bijwerkingen
van Grieken,
NCT
Beroep onder de loep:
klinisch patholoog
Van Kooyk, Y
Radiotherapie,
Newspaper (print)
chemotherapie en
operatief verwijderen zijn
de meest gangbare
therapieën tegen kanker
op dit moment. In de
onderzoekswereld is men
vooral bezig met de
diagnostiek. Hoe eerder
je erbij bent, hoe beter
een patiënt geholpen kan
worden. Door meer over
kanker te weten, kan een
tumor beter bestreden
worden. Er wordt veel
onderzoek gedaan naar
de genetische
afwijkingen van
kankercellen. Ook naar
het immuunsysteem is
altijd onderzoek gedaan,
maar pas sinds kort zijn
er bewijzen dat het
afweersysteem ingezet
kan worden bij de
bestrijding van kanker
Parool, 30-8-2013
Verheul, HMW
Wat we hier binnen VUmc Television
CCA doen is het
wetenschappelijk
onderzoek heel dicht bij
de patiënt brengen, door
nieuwe vindingen zo
spoedig mogelijk te
implementeren in de
zorg
RTV Noord Holland, 2010-2013
Het zou natuurlijk
fantastisch zijn als we
met de inzet van speciaal
getrainde honden een
hogere mate van
sensitiviteit en
nauwkeurigheid in de
opsporing van
darmkanker kunnen
behalen
Newspaper (print)
De Telegraaf, 9-12-2013
Verdonck-de
Leeuw, IM
Interview
Radio
Knooppunt Kranenbarg,
6-6-2013
Verweij, CL
Test voorspelt uitkomst
RA-behandeling met
rituximab
Rheum. News. Intern
4-4-2013
Interview voor
reumapatienten blad "In
beweging"
In beweging
4-4-2013
Wesseling, P
Award presentation
Television
Koffietijd' (national TV)
Würdinger, T
We willen begrijpen
waarom die stamcellen
Magazine
Ad Valvas, 26-8-2013
Appendix Annual Report 2013 Vumc CCA – Societal impact - 127
Associate
Topic
Medium
Name source
URL
Kankermedicijn wordt
Maatwerk
Newspaper (print)
Parool, 27-11-2013
http://www.parool.nl/
parool/nl/224/BINNEN
LAND/article/detail/35
52248/2013/11/27/K
ankermedicijn-wordtmaatwerk.dhtml
Kankermedicijn wordt
Maatwerk
Newspaper (print)
Algemeen Dagblad, 2711-2013
Kankermedicijn wordt
Maatwerk
Newspaper (print)
Nieuwsblad van het
Noorden, 27-11-2013
Designchemo
Magazine (online/print)
ZIN-magazine, 1-3-2013
Kankermedicijn wordt
Maatwerk
Newspaper (print)
Trouw, 27-11-2013
Meer kennis van
resistentiemechanismen
en het ontwikkelen van
nieuwe strategieën om
deze te omzeilen, kan de
overlevingskans van
patiënten aanzienlijk
verbeteren. Ook kan
beter worden voorspeld
hoe een tumor op een
bepaalde therapie zal
reageren
Magazine
Zorg- en ziekenhuiskrant
(January 25)
helemaal naar de
hersenen op reis gaan.
Want als we dat snappen
kunnen we het proces
misschien vertragen of
stoppen
Ylstra, B
Zander, S
http://www.ddock.nl/
wp-system/wpcontent/uploads/CCA
msterdam_Zin_septem
ber2013.pdf
Appendix Annual Report 2013 Vumc CCA – Societal impact - 128
Appendix 7. Ongoing projects
Program 1
Breast cancer
1. Genomic profiles for inherited breast cancer
M. Massink, S. van Mil, J.P. de Winter, Q. Waisfisz, H. Meijers-Heijboer
Department of Clinical Genetics, VU University Medical Center, Amsterdam
NWO VIDI Meijers-Heijboer
2. Towards targeted treatment of (familial) breast cancer
J.L. Bakker1, S. van Mil1, A.B. Oostra1, H.M.W. Verheul2, H. Meijers-Heijboer1, Q. Waisfisz1, J.P. de Winter1
1Department of Clinical Genetics and 2Department of Medical Oncology, VU University Medical Center
VUmc CCA
Cervical cancer
3. CINtec PLUS studie, p16 analyse van afwijken uitstrijken
C.J.L.M. Meijer
Department of Pathology, VU University Medical Center Amsterdam
Ventana Medical
4. Molecular Self Screening for Cervical Cancer Prevention
C.J.L.M. Meijer
Department of Pathology, VU University Medical Center, Amsterdam
EU ERC advan
Colorectal cancer
5. Clinical and biological relevance of focal deletions in colorectal cancer
O. Krijgsman1, G.A. Meijer1, B. Carvalho1, R.D. Steenbergen1, B. Ylstra1
Department of Pathology, VU University Medical Center, Amsterdam
Stichting Avanti STR
6. CRCbioscreen
B. Carvalho, R. Fijneman, C. Jimenez, G.A. Meijer
Department of Pathology and Medical Oncology, VU University Medical Center, Amsterdam
CTMM
7. Datamanagement voor moleculaire vroegdiagnostiek en therapieselectie bij darmkanker
J. Beliën, G.A. Meijer
Department Of Pathology, VU University Medical Center, Amsterdam
Stichting Avanti STR
8. Development of an improved molecular test for population-wide colorectal cancer screening
A.C. Hiemstra, B. Carvalho, R.J.A. Fijneman, C.R. Jimenez, C.J. Mulder, G.A. Meijer
Department of Pathology, Medical Oncology and Gastroenterology, VU University Medical Center, Amsterdam
Vrienden van het CCA
9. Development of screening tests for early detection of CRC
L. Bosch1, B. Carvalho1, M. van der Wiel1, V. Coupé1, M. van Engeland4 Y. van der Burgt5, W. van Criekinge6, C.R.
Jimenez2, R. Fijneman1, C.J. Mulder3, G.A. Meijer1
1Department Of Pathology, 2Department Medical Oncology (OncoProteomics Laboratory), 3Department
Gastroenterology, VU University Medical Center, 4MUMC, 5LUMC, MdXHEalth, 6Univ Gent
CTMM
10. Early detection of colorectal cancer by faeces derived microRNA testing
L. Timmer1, B. Diosdado1, E. Cuppen2, G.A. Meijer1
Department Of Pathology1, VU University Medical Center, Amsterdam, Hubrecht Laboratorium Utrecht2
KWF VU 2009-4276
11. Identification of novel oncogenes/oncomirs located at 13q involved in the progression of colorectal adenoma to
carcinoma
F.L.M. de Groen, R.D.M. Steenbergen, G.A. Meijer, B. Carvalho
Department Of Pathology, VU University Medical Center, Amsterdam
VUmc Cancer Center Amsterdam
12. Structural chromosomal rearrangements in colorectal cancer
E. van den Broek, R.J.A. Fijneman, G.A. Meijer
Department Of Pathology, VU University Medical Center, Amsterdam
VUmc Cancer Center Amsterdam
Head and neck cancer
13. Clinical and genetic aspects of hereditary paragangliomas
J.A. Rijken, E.F. Hensen, C.R. Leemans
Department of Otolaryngology and Head-Neck Surgery VU University Medical Center
14. Clinical significance of human papillomavirus infection in oropharyngeal squamous cell carcinoma
M. Rietbergen1, C.R. Leemans1, P.J.F. Snijders2, B. Witte3, R.J. Baatenburg de Jong4, B.J.M. Braakhuis1, E. Bloemena2,
R.H. Brakenhoff1
Departments of 1Otolaryngology - Head and Neck Surgery, 2Pathology, 3Epidemiology and Biostatistics, VU University
Medical Center, Amsterdam, 4Otolaryngology – Head and Neck Surgery, Erasmus Medical Center, Rotterdam
KWF VU 2009-4531
15. Determinants of radio and EGFR-mediated therapy sensitivity
C.R. Nagel, C.R. Leemans, B.J.M.Braakhuis, R.H. Brakenhoff
Department of Otolaryngology and Head-Neck Surgery, VU University Medical Center, Amsterdam
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -125
CTMM
16. Development of a personalized targeted treatment of head and neck cancer
A. van Harten, B.J.M. Braakhuis, C.R. Leemans, R.H. Brakenhoff
Department Otolaryngology and Head-Neck Surgery, VU University Medical Center, VU University Medical Center,
Amsterdam
VUmc Cancer Center Amsterdam
17. Early detection of primary and recurrent nasopharyngeal carcinoma (NPC) using (anti-) EBV based tumor markers and
options for using photodynamic therapy (PDT) in the treatment of local disease
I.B. Tan, S.M. Haryana, J.M. Middeldorp
Department of Pathology, VU University Medical Center Amsterdam, AKI-AvL, Amsterdam, UGM, Yoguakarta, Indonesia
KWF
18. Fanconi anemia: course of disease in rthe Dutch patient cohort and early recognition of cancer
S. Smetsers1,2, A. Brink1, R.H. Brakenhoff1
Departments of 1Otolaryngology - Head and Neck Surgery VU University Medical Center, Amsterdam, 2Paediatrics,
University Medical Center Utrecht
Kika
19. Identification of oncogenic microRNAs and cancer genes involved in head and neck squamous cell carcinoma by a
functional genomics approach
M. Lindenbergh-van der Plas, B.J.M. Braakhuis, C.R. Leemans, R.H. Brakenhoff
Section Tumor Biology, Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam
VUmc Cancer Center Amsterdam
20. Improving molecular staging of surgically treated head and neck cancer patients: towards rationalized adjuvant
treatment
A.P. Graveland1, M. de Maaker1, E. Bloemena2, B.J.M. Braakhuis1, C.R. Leemans1, R.H. Brakenhoff1
Departments. 1Otolaryngology/Head-Neck Surgery and 2Pathology, VU University Medical Center, Amsterdam, University
Utrecht
NKB/KWF 2005-3285 en 2006-3694
21. Molecular diagnosis of head and neck squamous cell carcinoma
B.J.M. Braakhuis1, W. van Wieringen2, B. Ylstra3, O. Krijgsman3, Q. Voorham3, C.R. Leemans1, R.H. Brakenhoff1
Departments 1Otolaryngology - Head and Neck Surgery, 2Epidemiology and Biostatistics, 3Pathology, VU University
Medical Center, Amsterdam
22. Novel tumor-selective lethal miRNAs for the treatment of head and neck cancer ("MIRacle")
S. Martens-de Kemp, M. Buijze, R.H. Brakenhoff
Department of Otolaryngology and Head-Neck Surgery VU University Medical Center, Amsterdam
EU-FP7-SME 2013-606486
23. Targeted therapy of precancerous fields in head and neck mucosa
D.V. de Boer1, M. Stigter-van Walsum1, B.J.M. Braakhuis1, V.W. van Beusechem2, R.H. Brakenhoff1
Department of 1Otolaryngology - Head and Neck Surgery, 2Medical Oncology, VU University Medical Center, Amsterdam
VUmc Cancer Center Amsterdam
24. Targeted treatment of oral cancer and precancer in FA
S. Martens-de Kemp1, V.W. van Beusechem2, R.H. Brakenhoff1
Department of 1Otolaryngology - Head and Neck Surgery, 2Medical Oncology, VU University Medical Center, Amsterdam
Fanconi Anemia Research Fund
25. The Fanconi anemial/BRCA pathway in head and neck squamous cell carcinomas
C. Stoepker1, N. Ameziane1, P. van de Lelij1, J.A. Balk1, A.B. Oostra1, M.A. Rooimans1, J. Steltenpool1, S. Martens-de
Kemp2, R.H. Brakenhoff2, H. Joenje1, J.P. de Winter1
1Department of Clinical genetics and 2Department of Otolaryngology/Head and Neck Surgery, VU University Medical
Center, 3Department of Oncology, University of Oxford
VUmc CCA
HPV-induced tumors
26. Clinical evaluation of methylation markers for risk assessment of high-risk HPV-positive women for cervical cancer and
its high grade precursors
L. de Strooper, C.J.L.M. Meijer, P.J.F. Snijders, D.A.M. Heideman
Department Of Pathology, VU University Medical Center Amsterdam
KWF 2009-4522
27. Comprehensive analysis of the long-term oncogenic capacity and in vitro transforming property of the 15 high-risk
human papillomavirus types
D.M. Schütze, R. van Baars, J. van der Marel, P.J.F. Snijders, R.D.M. Steenbergen, W. Quint, C.J.L.M. Meijer
Department of Pathology, VU University Medical Center, Amsterdam
HUMAVAC
28. Comprehensive molecular characterisation of a longitudinal in vitro model of high-risk HPV-mediated transformation
V. Miok1, S.M. Wilting1, R.D.M. Steenbergen1, W.N. van Wieringen2, P.J.F. Snijders1
Department Pathology1 and Epidemiology & Biostatistics2, VU University Medical Center Amsterdam
St. VUmc CCA
29. Discover and validation of molecular triage markers to stratify women with hrHPV positive self-samples for colposcopy
directed biopsy by the gynaecologist
B.C. Snoek, R.D.M. Steenbergen, D.A.M. Heideman, C.J.L.M. Meijer, P.J.F. Snijders
Department of Pathology, VU University Medical Center Amsterdam
30. Discover and validation of molecular triage markers to stratify women with hrHPV positive self-samples for colposcopy
directed biopsy by the gynaecologist
W. Verlaat, R.D.M. Steenbergen, D.A.M. Heideman, C.J.L.M. Meijer, P.J.F. Snijders
Department of Pathology, VU University Medical Center Amsterdam
31. Health-economic modelling of prevention strategies for HPV-related diseases in European countries
H. Berkhof, C.J.L.M. Meijer
Department of Pathology and Biostatistiek&Epidemiologie, VU University Medical Center, Amsterdam
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -126
EU en ZonMw
32. HPV vaccination
M. Mollers, M. Scherpenisse, C.J.L.M. Meijer
Department Of Pathology, VU University Medical Center, Amsterdam
RIVM
33. Identification and clinical validation of methylation markers for cervical adenocarcinomas and their precursor lesions
S. Snellenberg, C.J.L.M. Meijer, P.J.F. Snijders, R.D.M. Steenbergen
Department of Pathology, VU University Medical Center, Amsterdam
KWF 2007-3771
34. Identification of miRNAs and other ncRNAs as biomarkers for cervical cancer and assessment of their potential
functional relevance in HPV-mediated transformation
S.Wilting , P.J.F. Snijders, R.D.M. Steenbergen
Department of Pathology, VU University Medical Center, Amsterdam
Stichting Avanti STR
35. Improving detection-efficiency of CIN2/3+ in non responder-women that test positive for hrHPV in a self-collected
sample: design of PROTHECT 3 trial (Schadelastreductie baarmoederhalskanker door vernieuwend beleid ten aanzien van
niet-deelnemers BVO-BMHK)
V. Verhoef, F. van Kemenade1, D.A.M. Heideman1, P.J.F. Snijders1, M. van Baal2, L. Masuger3, R. Bekkers3, W.
Melchers4, R. Hol5
Department Of Pathology1 and Gynaecology2, VU University Medical Center Amsterdam, Department Gynaecology,
UMCN3, Mol. Diagnostics, UMCN4, Delphi Biosciences5
St. Bevolkingsonderzoek midden-west/Achmea Gezondheidszorg
36. Improving detection-efficiency of CIN3+ in non responder-women that test positive for hrHPV in a self-collected sample:
design of PROTHECT 3 trial
F. van Kemenade1, D.A.M. Heideman1, P.J.F. Snijders1, M. van Baal2, L. Masuger3, R. Bekkers3, W. Melchers4, R. Hol5
Department Of Pathology1 and Gynaecology2, VU University Medical Center Amsterdam, Department Gynaecology,
UMCN3, Mol. Diagnostics, UMCN4, Delphi Biosciences5
St. Bevolkingsonderzoek midden-west
37. Profiling of aberrant microRNA methylation events that are functionally relevant during cervical carcinogenesis
S.M. Wilting, R.D.M. Steenbergen, P.J.F. Snijders
Department Of Pathology, VU University Medical Center
KWF 2010-4668
38. Simplified monitoring post-treatment CIN 2/3 women by molecular testing for hrHPV and methylation markers
M. Uijterwaal1, C.J.L.M. Meijer1, Th.J.M Helmerhorst2, R.D.M. Steenbergen1
1VU University Medical Center, Amsterdam, 2Erasmus University Medical Center, Rotterdam
KWF 2009-4413
Immunotherapy
39. Physiological role of EBV-LMP1 in MHC-II+exosomes for tumor immune escape across the immunological synaps:
Implications for prognosis and immunotherapy
F. Verweij, E. Hooijberg, J.J.C. Neefjes, J.M. Middeldorp, D.M. Pegtel
Department of Pathology, VU University Medical Center
KWF 2007-3775
Lung cancer
40. Evaluation of molecular sputum test diagnostic for lung cancer
A.J. Hubers, D.A.M. Heideman, E.F. Smit, F.B.J.M. Thunnissen
Department of Pathology1 and Pulmonology2, VU University Medical Center, Amsterdam
KWF VU 2008-4220
41. Genomic profiling for risk assessment of preneoplastic endobronchial lesions
R.A.A. van Boerdonk, P.J.F. Snijders, E.F. Smit, D.A.M. Heideman,
Department of Pathology1 and Pulmonology2, VU University Medical Center, Amsterdam
KWF VU 2008-3898
Retinoblastoma
42. Genomics to improve diagnostics and care of retinoblastoma patients
E.I. Kooi1,5, B.M. Mol1, T. van Harn2, A.C. Moll3, J. Cloos4,5, G.J.L. Kaspers5, H. te Riele1,2, J.C. Dorsman1
Departments of 1Clinical Genetics, 3Opthalmology, 4Hematology, 5Pediatric Oncology/ Hematology, VU University
Medical Center, Amsterdam, The Netherlands. 2Division of Molecular Biology, The Netherlands Cancer Institute,
Amsterdam
Stichting KIKA Kinderen Kankervrij
43. The molecular carcinogenesis of retinoblastoma
B.M. Mol1, E.I. Kooi1, A.C. Moll2, D.A.P. Rockx1, W.A Kors3, M.I. Bosscha2, C. Dommering1, H. Joenje1, H. te Riele1,5, J.
Cloos3,4, J.C. Dorsman1
Departments. of 1Clinical Genetics, 2Ophthalmology, 3Pediatric Oncology/Hematology, 4Hematology VU University
Medical Center, Amsterdam and 5Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
VUmc CCA Stichting Avantie STR (round 2008)
Other
44. A quantitative proteome progression model for squamous cell cancer
M. Rietbergen, E. Bloemena
Department of Pathology, VU University Medical Center Amsterdam
Nat Prot. Center
45. Role of the soluble viral BARF1 oncoprotein in Epstein-Barr virus-driven carcinogenesis and its functional inhibition by
antibodies
E.K. Hoebe, J.M. Middeldorp
Department of Pathology, VU University Medical Center, Amsterdam
KWF VU2007-3776
46. Towards improved melanoma treatment: gene identification, in vivo modeling and drug target discovery
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -127
D. Peeper, W.J. Mooi
Department Of Pathology, VU University Medical Center, Amsterdam
KWF
Program 2
Cancer
1. Antibody based therapeutic intervention in Head and Neck Squamous Cell Carcinoma
J.E.Bakema1, S.H.Ganzevles1, B.J.M. Braakhuis1, C.R. Leemans1, R.H. Brakenhoff1, C.Tuk2, M.van Egmond2, L. P.E. van
der Steen2 ,W.Unger2, A.A. van de Loosdrecht3, G.Vidarsson 4, T.Valerius5, and E. Breij6.
1Department Otolaryngology – Head and Neck Surgery, 2 Department of Molecular Cell biology and Immunology, 3
Department of Haematology, VU University Medical Center, Amsterdam, the Netherlands. 4Department of Experimental
Immunohematology, Sanquin Blood Supply Foundation, Amsterdam, the Netherlands. 5 Christian-Albrechts-Universität
zu Kiel, Kiel, Schleswig-Holstein, Germany. 6Genmab B.V., Utrecht, The Netherlands
2. Exploring the sweet spot in colon cancer mutations
K. Lenos 1, R.J. Fijneman 2, Y. van Kooyk 1, S.J. van Vliet 2
Department of Molecular Cell Biology1 and Pathology 2 VU University Medical Center
VUmc Cancer Center Amsterdam
3. Glycosylation of the Prostate Antigen PSA as predictive marker for prostate cancer
M. van den Berk, S.J. van Vliet, Y. van Kooyk
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
Eurostars
4. iNKT and Vγ9Vδ2-T cell based immunotherapies for solid tumors
R.C. de Bruijn1, F.L. Schneiders1, R. Lameris, R.J. Scheper2, A.J.M. van den Eertwegh1, G.A.M.S. van Dongen3, R.C.
Roovers4, P.M. van Bergen en Henegouwen5, H.M.W. Verheul1, T.D. de Gruijl,1 H.J. van der Vliet1.
Departments of 1Medical Oncology, 2Pathology, and 3Otolaryngology/Head and Neck Surgery, VU University Medical
Center, Amsterdam and 4 Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, and 5Cell Biology,
Department of Biology, Utrecht University, Utrecht, The Netherlands
ZonMw Clinical Fellowship, KWF Clinical Cancer Research Fellowship
5. Macrophages and tumour development
R. Braster1, M. Bögels1,2, R.H.J. Beelen2, M. van Egmond1,2
Departments. of 1Surgery and, 2Molecular Cell Biology and Immunology, VU University Medical Center
Eerste geldstroom via MCBI r
6. Macrophages as effector cells for monoclonal antibody therapy of cancer
N. Gül1, R. Braster1, M. van Egmond1,2
Departments of 1Molecular Cell Biology and Immunology and 2Surgery VU University Medical Center
Eerste geldstroom via MCBI and KWF
7. Notch-signaling in tumor-specific T cells to improve anti-tumor immunity
L.Kuijk, MI Verstege, T.de Gruijl, E. Hooijberg, Y. van Kooyk, WWJ Unger
Department Mol Cell biol and Immunol , Pathology and Medical Oncology, VU University Medical Center, Amsterdam
VUmc Cancer Center Amsterdam CCA2011-5-01
8. Novel strategies for antibody therapy of cancer
L. van der Steen1,2, C. Tuk2, A. van de Loosdrecht3, J. Bakema4, M. van Egmond1,2
Departments of 1Surgery, 2Molecular Cell Biology and Immunology, 3Hematology and 4Otolaryngology/Head-Neck
Surgery, VU University Medical Center
Stichting VUmc CCA
9. Promoting antitumor immunity by specific tumor-targeting of iNKT cells
J.J. van der Vliet1, T.D. de Gruijl1, G.A.M.S. van Dongen2
1Department Of Medical Oncology and 2Otolaryngology/Head-Neck Surgery, VU University Medical Center, Amsterdam
ZonMw
10. Proteasome inhibitors and effects on immune effector cells in autoimmunity and cancer
G. Jansen, T.D. de Gruijl, R.J. Scheper, B. Dijkmans
Department of Reumatology, Medical Oncology and Pathology, VU University Medical Center Amsterdam
11. Specific tumor-targeting of iNKT cells and VγVδ2 T cells using nanobody technology
T.D. de Gruijl1, H.M.W. Verheul1, R.J. Scheper2, J.J. van der Vliet1
1Department Of Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam
KWF fellowship
12. Surgery induced development of liver metastases
S. Grewal1,2, N. Gül1, R.H.J. Beelen1, J. Bonjer2, M. van Egmond1,2
Departments. of 1Molecular Cell Biology and Immunology, and 2Surgery, VU University Medical Center
NWO, Mozaiek
13. Targeting solid tumors and their myeloid infiltrate by specific nanobodies
D. Chondronasiou, J.J. van der Vliet, H.M.W. Verheul, T.D. de Gruijl
Department of Medical Oncology, VU University Medical Center Amsterdam
14. The role of galectin-4 in progression of pancreatic cancer
A. Belo1, Mina Maftouh2, E. Giovannetti2, I.M. van Die1
1Department of Molecular Cell Biology and Immunology and 2Dept of Medical Oncology, VU University Medical Center,
VUmc, Amsterdam
Portuguese FCT to A. Belo
Cancer - Dendritic cells
15. Antigen-specific inhibition of encephalitogenic T cells by selective targeting of corticosteroid/antigen-loaded liposomes
to cervical lymph node dendritic cells
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -128
I. Streng-Ouwehand; M.I. Verstege, M.Litjens, Y. van Kooyk, W.W.J. Unger
Dept. of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam
16. Dendritic cell targeting using nanovesicles to improve anti-cancer therapy
W.W.J. Unger, M. Verstege, S. Engels Y. van Kooyk
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
SENTERNOVEM, NanoNext Initiative
17. Dendritic cell-targeted in vivo tumor vaccination: towards optimised prime-boost protocols
B.N. Hangalapura1, D. Oosterhoff1, van de Ven1, J. van Moorselaar2, A.G.M. Stam3, R. E. Hooijberg3, V.W. van
Beusechem1, W.R. Gerritsen1, A.J.M. van den Eertwegh1, R.J. Scheper3, Y. van Kooyk4, T.D. de Gruijl1
Departments. of 1Medical Oncology, 2Urology, 3Pathology, and 4Molecular Cell Biology and Immunology, VU University
Medical Center, Amsterdam
KWF-VU / Stichting CCA 2005-3284
18. In situ targeting and modulation of dendritic cells for immunotherapy: reversal of suppression
R. van de Ven1, J.J. Lindenberg1, D. Oosterhoff1, S.M. Lougheed1, V.W. van Beusechem1, R.J. Scheper2, P. van den Tol3,
D.T. Curiel4, A.J.M. van den Eertwegh1, T.D. de Gruijl1
Depts. of 1Medical Oncology, 2Pathology, and 3Surgical Oncology,VU University Medical Center, Amsterdam and Division
of Human Gene Therapy, UAB, Birmingham, Alabama
NWO VIDI 917.56.321
19. Interactions between CD169+ macrophages and dendritic cells
H. Veninga, E. Borg, H. Kalay, Y. van Kooyk, G. Kraal, J.M.M. den Haan
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
KWF VU2009-4504
20. Targeting dendritic cells with glycosylated liposomes in defense against prostate cancer
A.J. van Beelen1, B. Hangalapura2, T.D. de Gruijl2, Y. van Kooyk1
Departments. of 1Molecular Cell Biology and Immunology, VU University Medical Center, and 2Medical Oncology, VU
University Medical Center
VUmc Cancer Center Amsterdam
Dermatology
21. Keloid
S. Gibbs, F. Niessen, R.J. Scheper
Department of Pathology and Dermatology, VU University Medical Center, Amsterdam
Agentschap NL
22. Novel in vitro assays for detection of sensitizers
S.W. Spiekstra1, T. Rustemeyer1, S. Gibbs1
Departments of 1Dermatology, VU University Medical Centre
23. Novel saliva-derived peptides for state-of-the-art clinical wound-healing applications
S. Gibbs, E. Veerman, R.J. Scheper
Department of Pathology and Dermatology, ACTA, VU University Medical Center, Amsterdam
STW
24. Prevalidation of a two-tiered approach to determine the skin sensitising capacity and potency of chemicals
J. Reijnders1, S.W. Spiekstra,1 , E. Corsini2 , R. Roggen3 , R. Pieters4, S. Casati5. C. Krul6, S. Gibbs1
1Dermatology, VU University Medical Centre, 2 University of Milan, Milan, 3 Novozymes, Denmark, 4 Hoge School,
Utrecht, 5 ECVAM, Ispra, 6 TNO, Utrecht
ZON-MW PAD grant 40-40100-94-09015
25. Skin and mucosal allergies to dental metals
D Rachmawati, J. Muris1) von Blomberg BME, R.J. Scheper, .M.W. van Hoogstraten
Department Of Pathology, VU University Medical Center, Amsterdam; 1) Department dental materials Science, ACTA,
Amsterdam, Department Nat. Educ. Indon., Directorat General of Higher Degree education
Dept. Nat. Educ. Indon., Directorat General of Higher Degree education
26. The development of immuno-competent human skin and oral mucosa equivalents and their use in determining factors
involved in T cell skewing and imprinting
I. Kosten1, S.W. Spiekstra1, B.M.E. von Blomberg2, T. Rustemeyer1, R.J. Scheper2, T.J. De Gruijl2, S. Gibbs1
Departments of 1Dermatology and 2Pathology, VU University Medical Center
VUmc CCA OIO
27. Vascular growth in skin equivalents
S. Gibbs, V. van Hinsbergh, R.J. Scheper
Department of Pathology and Dermatology, VU University Medical Center, Amsterdam
Neth Inst Regenerative Med Ministerie
Gastroenterology
28. Exploration of novel therapeutic options for refactory CD (RCD) and EATL
S. Cillessen, M. von Blomberg, H.J. Bontkes, G. Bouma, C. Mulder
Department Of Pathology and Gastroenterology, VU University Medical Center, Amsterdam
Celiac Disease Consortium (CDC/NGI)
29. HLA-DQ genotype distribution in Type 1 Diabetes Mellitus patients with concomitant Celiac Disease
S.F. Bakker1, M.E. Tushuizen1, J.B.A. Crusius 2, S Simsek3 , C.J.J. Mulder1, B.M.E. von Blomberg4
1 Department of Gastroenterology and Hepatology, VU University Medical Center, The Netherlands, 2 Laboratory of
Immunogenetics,Department of Medical Mirobiology and Infection Control, VU University Medical Center, Amsterdam,
The Netherlands, 3 Department of Internal Medicine, Medical Center Alkmaar, The Netherlands, 4 Department of
Medical Immunology, VU University Medical Center, The Netherlands Coeliac Disease Consortium
30. Prognostic and diagnostic marker analysis in (refractory) celiac disease
S. Gross, B. M.E. von Blomberg, H.J. Bontkes, I.M.W. van Hoogstraten, K.A.G. Gelderman, G. Bouma, S. Cillessen, C.J.
Mulder, F. Koning
Department Of Pathology and Gastroenterology, VU University Medical Center Amsterdam, LU University Medical Center
Leiden
Celiac Disease Consortium (NGI)
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -129
31. Protection against inflammatory bowel diseases by glycan antigens
E.J. Klaver1, G. Bouma2, G. Kraal1, I.M. van Die1
1Department of Molecular Cell Biology & Immunology, VUmc, Amsterdam; 2Department Gastroenterology, VU University
Medical Center, Amsterdam
the Broad Medical Research Program of the Broad Foundation (USA)
32. The influence of vitamin A metabolism on immune cell differentiation in the gut
Y. Bar-Ephraïm, G. Goverse, K. Lakeman, R.E. Mebius
Department Of 1Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam
CCA
Host pathogen interaction
33. EBV-MicroRNA containing exosomes: Trojan vesicles carrying hostile message
D.M. Pegtel, D.A. Thorley-Lawson, J.M. Middeldorp
Department of Pathology, VU University Medical Center and Tufts University, Boston, USA
NWO-Veni, ZonMW2008 OZ05PAT110038
34. Enteroviral infections in children
S. de Crom 1, Dr. Ch. Obihara 1, M. Peeters 2, S.A. Morré 3 , A. M. van Furth 4
1Department of Pediatrics, St. Elisabeth Ziekenhuis, Tilburg; 2 Department of Medical Microbiology , St. Elisabeth
Ziekenhuis, Tilburg; 3Laboratory of Immunogenetica, Department of Medical Mirobiology and Infection Control,VUmc,
Amsterdam; 4Department of Pediatric Infectious Diseases, Immunology, and Rheumatology, VUmc, Amsterdam
35. Genetic profiling in bacterial meningitis
O. El Tahir, S. Ouburg1 , S.A. Morré1 , A.M. van Furth2
1Laboratory of Immunogenetica, Department of Medical Mirobiology and Infection Control,VUmc, Amsterdam;
2Department of Pediatric Infectious Diseases, Immunology, and Rheumatology, VUmc, Amsterdam
36. Immunogenetic, pharmacological and neurodevelopmental aspects of nosocomial sepsis and meningitis in preterm AGA
and SGA infants
F. van den Dungen1 , S.A. Morré2, P. Savelkoul3, M. M. van Weissenbruch1, A.M. van Furth4
1Department of Neonatology, VUmc, Amsterdam 2 Laboratory of Immunogenetica, Department of Medical
Mirobiology and Infection Control,VUmc, Amsterdam; 3Department of Medical Microbiology, VUmc, Amsterdam,
4Department of Pediatric Infectious Diseases, Immunology, and Rheumatology, VUmc, Amsterdam
37. Immunogenetics and environmental factors in infectious diseases
S. Ouburg1, Y. Pannekoek3, J. Lyons1, S. Verweij, M. Sanders, G. van Well, V. Smelov, J. Land5, C. Bruggeman6, C.
Hoebe6, A. Catsburg8, P.H. Savelkoul8, C.M.J.E. Vandenbroucke-Grauls8, M. van Agtmael9, M. van Furth 10, J.B.A.
Crusius1, A.S. Peña1, S.A. Morré1
1Laboratory Immunogenetics, Department of Medical Mirobiology and Infection Control,, 2GGD Amsterdam, 3AMC Med
Microbiol, 5AZM, Department Gynecol, 6AZM, Department Med Microbiol, 7Department Basic Dental Sci, 8Med Microbiol
Infect Prev, 9Int Med, 10 Pediatrics, VUmc, NL
38. Immunoglobulin A and neutrophil immunoglobulin A Fc receptor (Fc-alpha-RI) in mucosal infections
M.W.M. van Hout1, L. van der Steen1, J.E. Bakema1,2, M. van Egmond1,2
Departments. of 1Molecular Cell Biology and Immunology, and 2Surgery, VU University Medical Center
NWO
39. Improving early diagnosis of tuberculous meningitis in children
R. Solomons1, J. Schoeman1, A.M. van Furth2
Departments. of 1Tijgerberg Hospital, Cape Town, SA; 2Pediatric Infectiology, Immunology and Rheumatology, VU
University Medical Center, Amsterdam, The Netherlands
40. Inflammatory host defense in children with Down syndrome
C.J.M. Broers1, M.E.Wijerman1,2 ; R.J.B.J. Gemke1 , A.M. van Furth3,4
1Department of Pediatrics, VU medical center, 2Department of Pediatrics, Diaconesseziekenhuis, Leiden; 3 Department
of Pediatric Infectious Diseases-Immunology and Rheumatology, VU University Medical Center, Amsterdam; 4Laboratory
of Experimental Internal Medicine, Academical Medical Center, Amsterdam
41. Metabolomics Study of Tuberculous Meningitis in Children
S. Mason1, R.Solomons2, J.Schoeman2,R.Wevers3, C.Reinecke1, A.M. van Furth4
Departments. of 1Centre for Human Metabolomics, Potchefstroom, SA; 2 Tijgerberg Hospital, Cape Town, SA; 3 Clinical
Chemistry, UMC, Nijmegen; 4Pediatric Infectiology, Immunology and Rheumatology, VU University Medical Center,
Amsterdam, The Netherlands
42. Microbial control of the mucosal barrier function
I. Hiemstra, K. Vrijland, G. Bouma, G. Kraal, J.M.M. den Haan
Depts of Molecular Cellular Biology and Immunology and Gastroenterology, VU University Medical Center, Amsterdam
1e geldstroom
43. Predict TB: Model-based preclinical development of anti-tuberculosis drug combinations
M. Boot, S. Commandeur, A.M. van der Sar, W. Bitter
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam
EU-IMI
44. Predictionmodels in bacterial meningitis
O. El Tahir, S.A. Morré, A.M. van Furth
Department of Paediatrics and Medical Microbiology, VU University Medical Center, Amsterdam
Host pathogen interaction
45. Protein secretion systems of M. tuberculosis as novel target for drug development
V. van Winden, E.N.G. Houben, W. Bitter
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam
46. The effect of HIV infection and AZT-3TC-NVP/EVF therapy on vascular and metabolic changes in patienst with HIV
T.Msoka1, Y.Smulders2, M.van Agtmael2, J.Bartlett3, A.M. van Furth4
Departments. of 1Centre for Human Metabolomics, Potchefstroom, SA; 2 VUmc, Amsterdam, The Netherlands; 3 John
Hopkins, Baltimore, USA; 4Pediatric Infectiology, Immunology and Rheumatology, VU University Medical Center,
Amsterdam, The Netherlands
47. The host immune response to tuberculous meningitis
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -130
D. Visser 1 , R.Solomons2, J.Schoeman2, A.M. van Furth1
Departments. of 1Pediatric Infectiology, Immunology and Rheumatology, VU University Medical Center, Amsterdam, The
Netherlands; 2 Tijgerberg Hospital, Cape Town, SA
48. The rich focus in tuberculous meningitis: from pathology to mathematics
M. van der Kuip1, M. El-Kebir1, D. Kirschner2, A.M. van Furth1
Departments. of 1Pediatric Infectiology, Immunology and Rheumatology, VU University Medical Center, Amsterdam, The
Netherlands and 2Microbiology and Immunology, The University of Michigan Medical School, Ann Arbor, MI, USA
European Society for Paediatric Infectious Diseases / Wyeth (to MvdK) and the National Institutes of Health HL092853-01
(to DK)
49. Immune modulation by ESX-5 secreted proteins of mycobacteria
E.M. Weerdenburg, W. Bitter, B.J. Appelmelk
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam
V-ICI
50. Live mycobacterium bovis BCG bacteria as a platform for the induction of enhanced tumor-antigen-specific immunity
L.S. Ates, B. Appelmelk, J. Geurtsen, W. Bitter
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam
51. Mysteries beyond the mycomembrane:biogenesis of the mycobacterial capsule and its role in the host-pathogen
interaction
R. van de Weert, B. Appelmelk, C. Vandenbroucke-Grauls, J.J.G. Geurtsen
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam
NWO/ALW VENI
52. The role of the granulomaformation in tuberculous meningitis in zebrafish
L. van Leeuwen, M. van der Kuip, A. van der Sar, W. Bitter, A.M. van Furth
Department of Paediatrics and Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam
53. Unraveling a novel bacterial protein transport system: characterization of mycobacterial secretion system ESX-5
E.N.G. Houben, W. Bitter
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam
Immunology - Dendritic cells
54. Signaling pathways in homeostasis and function of dendritic cells
M. Beijer, G. Goverse, R.E. Mebius, G. Kraal and J.M.M. den Haan
Department of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
NWO-ALW Meervoud to J.M.M. den Haan
55. Targeting mMGL-1 and mMGL-2 on murine DCs to modulate immune responses
I. Ouwehand, E. Saeland, Y. van Kooyk
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
VUmc Research Institute: CCA/V-ICI
56. The design of glyco-peptide dendrimers to improve DC targeted antigen presentation
M. Ambrosini, M. Perdicchio, H. Kalay, J.J. Garcia Vallejo, Y. van Kooyk
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
Carmusys FP7 EU Marie Curie Network
57. Variations in T cell glycosylation direct the interaction with dendritic cells
S.J. van Vliet and Y. van Kooyk
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
Mizutani Foundation for Glycosciences
Immunology - General
58. Identification of differentialy glycosylated glycoproteins in human milk and their effects on DCs
N. Koning, E. Saeland, K. Bloem, S.J. van Vliet, Y. van Kooyk
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
TIPharma
Rheumatology
59. A phase 0 single dose study to evaluate the pharmacokinetics/-dynamics and specific targeting properties of 124-IF8IL10 in patients with active rheumatoid arthritis
Y. Gent1, M. Tsang a Sjoe1, O.S. Hoekstra2, G.A.M.S. van Dongen2, D. Vugts2, L. Giovanonni3, D. Neri4, C.J. van der
Laken1
Depts of 1Rheumatology, 2Radiology and Nuclear Medicine, VU University Medical Center, 3PHILOGEN S.p.A. , Sovicille
(SI), Italy, 4ETH, Zurich, Switzerland
FP7 Health program
60. Biomarkers in systemic lupus erythematosus
J. Jacobs, M.W.P. Tsang-A-Sjoe, L-A. Korswagen, B.A.C. Dijkmans, I.E.M. Bultink, A.E. Voskuyl
Department of Rheumatology, VU University Medical Center
61. Circulating microvesicles containing inflammatory viral RNA (EBER1) as indicators of SLE activity and organ involvement
N. Masoumi Kouhestani, M. Pegtel, A. Voskuyl, J. Middeldorp
Department of Pathology and Rheumatology, VU University Medical Center Amsterdam
62. Cross-talk between MGL and galectin-1 in the regulation of tolerogenic responses in multiple sclerosis
J.M. Ilarregui, G.A.Rabinovich1 and Y. van Kooyk
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam, 1IBYME;CONICET,
Buenos Aires, Argentina
Dutch Foundation MS Research
63. Immunoglobulin A Fc receptor (Fc-alpha-RI)-induced inflammatory diseases
E. Aleyd1, L. van der Steen1, R. Korthouwer1, S. Pouw1, S. Ganzevles1, J.E. Bakema1, M. van Egmond1,2
Departments. of Molecular Cell Biology and Immunology, and Surgery, VU University Medical Center
NWO, Agentschap NL, MaagLeverDarmStichting
64. MOG glycosylation and the induction of anti-inflammatory responses in Multiple Sclerosis
I. Vuist, J.J. Garcia-Vallejo, B. ‘t Hart1, Y. van Kooyk
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -131
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam, 1Department
Immunobiology, BPRC, Rijswijk
Dutch Foundation MS Research
Other
65. Control of chemokine signaling by stromal cell-associated heparan sulfate proteoglycans
R. Reijmers, R.E. Mebius
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
NWO
66. Development of a novel wound healing formulation for advanced wound management
S. Gibbs, R.J. Scheper
Department of Pathology and Dermatology, VU University Medical Center, Amsterdam
EuroTransBio Agentschap NL
67. Effect evaluation of home treatment program TBM, Cape Town, South Africa
S. van Elsland1; P. Springer2; J. Schoeman2; A.M. van Furth1
Departments. of 1Pediatric Infectiology, Immunology and Rheumatology, VU University Medical Center, Amsterdam, The
Netherlands; 2 Tijgerberg Hospital, Cape Town, SA
68. Glycan specificity of C-type lectins
K. Bloem, S. van Vliet, N. Koning, Y. van Kooyk
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
TIPharma
69. Helminth glycoproteins: a new therapeutic option to prevent or ameliorate MS?
G. Kooij, L. Laan, C.D. Dijkstra, I. van Die
Department of Molecular Cell Biology & Immunology, VUmc, Amsterdam
the Dutch Foundation MS Research
70. Large scale generation and analysis of glycovariants of Derp1 that down modulate the immune response in allergic
asthma
J.J. Garcia Vallejo1, J.M. Ilarregui1, H. Kalay1, I. Heijink2, Y. van Kooyk1
Departments. of 1Molecular Cell Biology & Immunology, VU University Medical Center, and 2Laboratory of Allergology
and Pulmonary Diseases, Department of Pathology and Medical Biology, University Medical Center Groningen, ,
Groningen
Astma Fonds 3.2.10.040
71. Mechanisms of mesenchymal cell differentiation towards stromal lymph node cells
J.J. Koning, G. Goverse, T. Konijn, R.E. Mebius
Department Mol. Cell Biology and Immunology, VU University Medical Center
NWO VICI grant 918.56.612
72. Regulation of functional differences between cord blood versus adult periperhal blood innate cells
Y. Bar-Ephraïm, K. Lakeman, A. Baptista, R.E. Mebius
Department Mol. Cell Biology and Immunology, VU University Medical Center
LSBR (Landsteiner Foundation for Blood Transfusion Research)
73. Retinoic acid mediates macrophage differentiation towards a separate lineage
G. Goverse, T. Konijn, R.E. Mebius
Department Mol. Cell Biology and Immunology, VU University Medical Center
NWO
74. Screening of new carbohydrate components that prevent pathogen binding to DC-SIGN
M. Perdicchio, M. Ambrosini, W. Unger, Y. van Kooyk
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
Carmusys FP7 EU Marie Curie Network
75. Spatial dynamics of lectin-carbohydrate interactions
S.J. van Vliet and Y. van Kooyk
Department of Molecular Cellular Biology and Immunology, VU University Medical Center Amsterdam
VENI NWO
76. Synergistic effects of TLR ligands and oligosaccharides
Y. van Kooyk, M. Boks
Department Mol Cell biol and Immunol, VU University Medical Center, Amsterdam
Tipharma
77. The generation of tolerance inducing vaccines
J.B. Vos, K. Vrijland, G. Kraal
Departments of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
Eurostar
Program 3
Brain cancer
1. Advanced glioma and correlation with histological and molecular characteristics
P. de Witt Hamer1, O. Hoekstra2, R. Boellaard2, F. Barkhof2, P. Wesseling3, J.C. Reijneveld4
Department of 1Neurosurgery, 2Radiology & Nuclear Medicine, 3Pathology, 4Neurology, VU University Medical Center
Amsterdam
VUmc Cancer Center Amsterdam
2. Anti-angiogenic treatment of gliomas
W. Leenders, W. van der Graaf, P. Wesseling
Department of Pathology, VU University Medical Center Amsterdam
RUNMC
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -132
3.
Expression of HER2 and other biomarkers in meningiomas: prediction of biological behaviour and potential targets for
therapy
V. ter Wengel, S.M. Peerdeman, W.P. Vandertop
Deparment of Neurosurgery, VU University Medical Center, Amsterdam
4. Identification of clinically relevant genetic aberrations in pediatric glioneuronal tumors
B. Ylstra1, P. Wesseling1, E. Aronica2, Schouten2
Department Of Pathology, 1VU University Medical Center Amsterdam, 2Amsterdam Medical Center
Edli Foundation
5. Immunotherapy of gliomas
G. Adema, P. Wesseling
Department of Pathology, VU University Medical Center Amsterdam
St. Stop Hersentumoren
6. Ontwikkeling celtherapie voor kinderen met wittestofziektes
S. Dooves1,2, J. Wortel1, C. van der Meer1, L. Thoolen1, T. Lagerweij3, C. Molthoff4, I. de Greeuw4, M. Verlaan4, V.
Heine1,2
Departments of 1Pediatrics and 2CNCR, 3Neuro-oncology Research Group, 4 Radiology & Nuclear Medicine, Vumc,
Amsterdam
NWO
7. Overcoming Temozolomide (TMZ) resistance in glioma
T. Würdinger1, P. Wesseling2
Department Of Neurosurgery1 and Pathology2, VU University Medical Center, Amsterdam
St. Stop Hersentumoren
8. Pediatric meningiomas in the Netherlands. Biomarkers as predictors for biological behaviour
N. Thuijs, S.M. Peerdeman, W.P. Vandertop
Deparment of Neurosurgery, VU University Medical Center, Amsterdam
9. Pilot study on the determination of tumor concentrations of protein kinase inhibitors in patients with newly diagnosed
high-grade glioma
M. van Linde1, K.E. Hovinga, P.C. de Witt Hamer2, T. Wurdinger2, M. Labots1, J. Buter1, G.J. Peters1, R. Honeywell1, C.R.
Jimenez1, J.C. Reijneveld3, P. Wesseling4, F.J. Lagerwaard5, J. Berkhof6, WP Vandertop2, H.M.W. Verheul1
Department of 1Medical Oncology, 2Neurosurgery, 3Neurology, 4Pathology, 5Radiotherapy, 6Epidemiology and
Biostatistics, VU University Medical Center Amsterdam
10. Prediction of progression in low-grade glioma using chromosomal copy number alterations
H.F. van Thuijl1,2, J.J. Heimans1, P. van der Valk2, B. Ylstra2, P. Wesseling2, J.C. Reijneveld1,3
Departments of 1Neurology and 2Pathology, VU University Medical Center, Amsterdam, Department of 3 Neurology,
Academic Medical Center, Amsterdam
KWF Kankerbestrijding VU 2009-4470
11. Promising drug combinations in the treatment of high-grade glioma
T. Wurdinger, P. Wesseling
Departments of Neurosurgery and Pathology, VU University Medical Center, Amsterdam
St. Stop Hersentumoren
12. Radiological aspects in meningioma surgery
M. Slot, S.M. Peerdeman, W.P. Vandertop
Deparment of Neurosurgery, VU University Medical Center, Amsterdam
13. Radiosensitizing invasive glioblastoma cells
P.M. van der Stoop, T. Wurdinger, P. Wesseling
Departments of Neurosurgery and Pathology, VU University Medical Center, Amsterdam
St. Stop Hersentumoren
14. Role of protein-tyrosine phosphatases in the biology of gliomas
W.J. Hendriks, W. Leenders, P. Wesseling
Department of Pathology, VU University Medical Center Amsterdam
RUNMC
15. The molecules of behavior: how brain tumors link cellular biology to large-scale brain networks and cognition
L. Douw12
1Department of Anatomy and Neuroscience, VUmc Amsterdam, 2Department of Radiology, Martinos Center for
Biomedical Imaging / MGH, Boston (USA).
NWO Veni
16. Towards effective immunotherapy of gliobastomas
G. Adema, P. Wesseling
Department of Pathology, VU University Medical Center Amsterdam
RUNMC
Cervical cancer
17. Cervix-care: biomarkers-based triage diagnosics for HPV positive women to detect cervical cancer
C.J.L.M. Meijer
Department of Pathology, VU University Medical Center Amsterdam
Eurostrats
Colorectal cancer
18. Building data bridges and services between biological and medical infrastructures in Europe
R. Voorham, J. van Denderen, J. Beliën, J.W. Boiten, G.A. Meijer
Department of Pathology, VU University Medical Center Amsterdam
EU-KP7
19. Laboratory tests in primary colorectal cancer
B. Carvalho1, M. van Engeland2, W. Corver3, B. Janssen4, W. van Criekinge5, G.A. Meijer1
Department Of 1Pathology, VU University Medical Center, Amsterdam, 2MUMC, 3LUMC, 4ServiceXS, MDXHEalth, Univ.
Gent
CTMM
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -133
20. Molecular imaging of early stage disease colorectal cancer
M. de Wit,2, R. Fijneman2, J. Verbeek1, A.D. Windhorst1, R. Lamerichs 3,4, C. Sio3, K. Donato3, J. Stoker4, G.A. Meijer2
Departments of 1Radiology & Nuclear medicine, 2Pathology, Vumc, 3 department of biomolecular imaging philips
research, 4department of radiology AMC
CTMM, DeCoDe
21. Peritoneal metastases from colorectal carcinoma; Diagnostic markers to identify patients that will benefit from radical
surgical resection
E. de Cuba1, H.J. Bonjer1, G.A. Meijer2, E.A. te Velde1
Department Of 1Surgery and 2Pathology, VU University Medical Center, Amsterdam
22. Personalized therapy in recurrent colorectal cancer
J. Goos1, R. Fijneman1, A.A. Geldof2, O.S. Hoekstra2, L. Perk3, G.A. Meijer1
Department of 1Pathology, 2Nuclear Medicine & PET reserach, VU University Medical Center, Amsterdam, 3BV Cyclotron
CTMM
23. Reducing CRC death in stage II carcinomas by identifying high/risk stage II cancer patients who could benefit from
adjuvant chemotherapy
B. Diosdado, R.Q.J. Schaapveld1, G.A. Meijer
Department of Pathology, VU University Medical Center Amsterdam, 1InteRNA Technologies BV
inteRNA
Genetic profiling
24. Development of a methodology to characterize the genome content of Livestock-associated MRSA
P.H.M. Savelkoul, C.M.J.E. Vandenbroucke-Grauls, J.A.J.W. Kluytmans
Department Medical Microbiology and Infection Control, VU University Medical Center Amsterdam
Agentschap.nl
25. DNAseq/RNAseq prostate and CRC
R.J.A. Fijneman, Ylstra B, Meijer GA
Department Of Pathology, VU University Medical Center Amsterdam
CTMM
26. Involvement of miRNAs in gastric cancer
G.A. Meijer
Department of Pathology, VU University Medical Center Amsterdam
FCT
27. Metastatic colorectal molecular laboratory tests
B. Ylstra1, B. Carvalho1, M. van Engeland2, W. Corver3, B. Janssen4, W. van Criekinge5, G.A. Meijer1
Department Of 1Pathology, VU University Medical Center, Amsterdam, 2MUMC, 3LUMC, 4ServiceXS, MDXHEalth, Univ.
Gent
CTMM
28. Predictive genomic biomarker methods for combination Bevacizumab (Avastin) therapy in metastatic colorectal cancer
B. Ylstra
Department of Pathology, VU University Medical Center Amsterdam
EU
29. TRACER Genomic biomarkers to predict development of RA (VERA, ERA), and therapy responsiveness (ESRA) (WP5)
J. Lübbers, E. Mantel, A.E. Voskuyl, R. Out, C. Verweij
Dept. of Pathology, Dept. of Rheumatology, Flexgen
CTMM
Head and neck cancer
30. FALCON - Intra-operative fluorescent parathyroid glands localization
A.F. Engelsman1, C.F.M. Molthoff2, A.D. Windhorst2, I. de Greeuw2, W.A. Adamzek2, M. Verlaan2, G.A.M.S. van Dongen2
1Dept. of Surgery, AMC medical center and 2Dept. of Radiology&Nuclear Medicine, Vumc Amsterdam
AMC
31. Improvement of the diagnosis of head and neck squamous cell carcinoma (HNSCC)
R. de Bree1, G. Flach1 , D.A. Heuveling1, S. Faraj-Hakim1, C.S. Schouten, L. van der Putten1, I. van der Waal2,, H.
Karakazoglu2, E.F.I. Comans3, A. Van Schie3, O.S. Hoekstra3, J.A. Castelijns3, P. de Graaf 3, E. Bloemena4, C.R.
Leemans1
Depts. of 1Otolaryngology-Head and Neck Surgery, 2Oral and Maxillofacial Surgery, 3Radiology and Nuclear Medicine,
and 4Pathology, VU University Medical Center, Amsterdam
ZonMw
32. Peri-implantitis, implant loss and radio-osteonecrosis in head and neck tumor patients
H. Dekker, R. Ramawadh, E. Bloemena
Department of Pathology, VU University Medical Center Amsterdam
ACTA IOT, Straumann, MKA
Hematology
33. EBV markers in CLL cases from Spain
De Sanjose, J.M. Middeldorp
Department Of Pathology, VU University Medical Center Amsterdam
Imaging
34. Design and production of anti-body drug conjugates (ADC), anti-body tracer conjugates (ATC) and other disease-targeted
devices
D. Waalboer, G.A.M.S. van Dongen
Department of Otolaryngology/Head-Neck Surgery, Radiology & Nuclear Medicine, VU University Medical Center
LinXis
35. FLT- and FDG-PET imaging to support dose-finding for the CD-44 (RO5429083) program in pre- clinical xenograft studies
C.F.M. Molthoff1, I. de Greeuw1, M.Verlaan1, R. Bergstra1, A.A. Lammertsma1
Department of 1Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam
Roche Diagnostics, Germany
36. FLT PET and DW MRI as markers of proliferation: technical validation
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -134
1V Frings, 1IC Pieters-van den Bos, 2JPA Kuijer, 1OS Hoekstra, 2EF Smit, 3CW Menke-van den Houven v Oordt, 1R
Boellaard
Departments of 1Radiology & Nuclear Medicine, 2Physics & Medical Technology, 3Pulmonology, 4Medical Oncology,
VUmc
EU IMI project Quic-Concept
37. In vivo imaging of Epstein Barr Virus Activation by cytolytic antiviral therapy in nasopharyngeal carcinoma cell lines and
xenograft models
Z. Novalic1, M. Verlaan2, J. Eersels2, C.F.M. Molthoff2, A.E. Greijer1, J.M. Middeldorp1
Depts. of 1Pathology and 2Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam
ZonMW, KWF
38. Measurement of tumor kinase inhibitor concentrations using PET imaging in patients with advanced solid malignancies
(PIKTURE)
L. Mammatas, C. Menke,A.A. Lammertsma, A.D. Windhorst, N.H. Hendriks, H.M.W. Verheul
Department of Medical Oncology and Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam
39. Multimodal imaging of orthotopic tumors: validation study
C.F.M. Molthoff1, A. Avan2, E. Giovanetti2, T. Lagerweij3, R. Bergstra1, I. de Greeuw1, G.J. Peters2, T. Würdinger3, D.
Fuchs4, P. Trochet4, J. Jose4
Departments. of 1Radiology & Nuclear Medicine, 2Medical Oncology, 3Neuro-oncology Research Group, VU University
Medical Center, Amsterdam and 4VisualSonics Europe, Amsterdam
40. PET studies in female C57Bl/6 WT mice after single treatment of GA504-mIL2 (CEA IgG-IL2v)
C.F.M. Molthoff1, I. de Greeuw1, M.Verlaan1, R. Bergstra1, E. Borg, J.J.M. den Haan2
Department of 1Radiology & Nuclear Medicine and 2Molecular Cell Biology and Immunology, VU University Medical
Center, Amsterdam
Roche Diagnostics, Germany
41. Quantitative imaging in cancer: connecting cellular processes with therapy: Data and Image Analysis (WP4)
L.L. Hoyng, M. Yaqub, F. van Velden, R. Boellaard
Department Of Radiology & Nuclear Medicine, Vu University Medical Center, Amsterdam
IMI EU project QuicConcept (EORTC, CR-UK, EFPIA)
42. Technical validation of DW-MRI, FLT and ICMT-PET as read-outs of proliferation and apoptosis in drug development
V. Frings1, L. Hoyng1, JPA Kuijer2, IC Pieters1, R Boellaard1, EF Smit3, W Menke-van den Houven v Oordt4, OS Hoekstra1
Department of 1Radiology & Nuclear Medicine, 2Physics & Medical Technology, 3Pulmonary Oncology, 4Medical
Oncology, VU University Medical Center, Amsterdam
IMI EU project QuicConcept (EORTC, CR-UK, EFPIA)
43. The development of radiolabeled tyrosine kinase inhibitors for PET imaging
P. Slobbe, G.A.M.S. van Dongen
Department of Otolaryngology/Head-Neck Surgery, Radiology & Nuclear Medinie, VU University Medical Center,
Amsterdam
VUmc Cancer Center Amsterdam
44. Towards targeted therapy: quantitative imaging with PET and long lived isotopes
N. Makris, R. Boellaard, M.C. Huisman, A.A. Lammertsma
Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam
Philips Healthcare
Imaging - Antibodies
45. Antibody derivatives as molecular agents for neoplastic targeting
D. Vugts1,2, G.W.M. Visser2, A. Vervoort2, G.A.M.S. van Dongen1,2
Department of 1Otolaryngology - Head and Neck Surgery, and 2Radiology & Nuclear Medicine, VU University Medical
Center, Amsterdam
Roche
46. Imaging of cell surface antigen with radiolabeled antibodies
D. Vugts, G.A.M.S. van Dongen
Department of Otolaryngology/Head and Neck Surgery and Radiology & Nuclear Medicine, VU University Medical Center
Roche
47. Pharmacokinetic modelling of PET tracers in oncology
E Verwer, AA Lammertsma, EF Smit, OS Hoekstra, R Boellaard
Departments of Pulmonology, Radiology & Nuclear Medicine, VUmc
CTMM AiRForce
48. Profiling responders in antibody therapies
vacature, L. van der Laken, G.A.M.S. van Dongen
Department of Otolaryngology/Head-Neck Surgery, Radiology & Nuclear Medicine, VU University Medical Center
European Community 7th Framework Project
49. SelecTive aRmed Antibodies as Drugs Against cancer
vacature, G.A.M.S. van Dongen
Department of Otolaryngology/Head-Neck Surgery,Radiology & Nuclear Medicine, VU University Medical Center
European Communitu Collaborative project
50. The selective targeting of angiogenesis and of tumour stroma
R. Cohen1, R. de Bree1, M. Stigter-van Walsum1, G.W.M. Visser2, D. Neri3, C.R. Leemans1, G.A.M.S. van Dongen1,2
Department 1Otolaryngology/Head and Neck Surgery, 2Radiology & Nuclear Medicine, VU University Medical Center,
Amsterdam, 3Swiss Federal Institute of Technology,Zürich, Switzerland
European commision FP6-LSHC-CT-2003-503233
Imaging - Brain tumours
51. Assessment of blood-brain barrier function in pharmacoresistant patients with tumor-related epilepsy
F. Froklage1, R.A. Voskuyl7, J.J. Heimans1, N.H.M. Hendrikse3,4, J.C. Baayen2, R.M.C. Debets6, D. Velis5, A.A.
Lammertsma3, J.C. Reijneveld1,5,
Departments of 1Neurology, 2Neurosurgery and 3Radiology & Nuclear Medicine, 4. Clinical Pharmacology and Pharmacy,
VU University Medical Center, Department of 5Neurology, Academic Medical Center, Amsterdam, Departments of
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -135
5Neurology and 6Clinical Neurophysiology, Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, and
7Department of Pharmacology, Leiden/Amsterdam Center for Human Drug Research (L/A CHDR), Leiden
Europese Unie Framework Program 7 (FP7 EURIPIDES project)
52. The effect of dexamethasone on the biodistribution of [3-N-11C-methyl]temozolomide in glioblastoma multiforme
patients; a pilot study
M. van Linde1, H.M.W. Verheul1, B.N.M. van Berckel, M.Yaqub2, J.Eriksson, C.H. Polman3, A.A. Lammertsma2, J.J.
Heimans3, N.H. Hendrikse4, E.A.M Froklage2, J.C. Reijneveld3
Department of 1Medical Oncology, 2Radiology and Nuclear Medicine, 3Neurology, 4Pharmacy, VU University Medical
Centerl Amsterdam
Imaging - Colorectal cancer
53. Development validation of predictive PET tracers in patients with colorectal cancer liver metastases
J.A.C.M. Goos1,2, R. Fijneman2, J. Verbeek1, M.P. van den Tol3, H.M.W. Verheul4, A.D. Windhorst1, A.A. Geldof1, O.S.
Hoekstra1, G.A. Meijer2
Departments of 1Radiology & Nuclear medicine, 2Pathology, 3Surgery, 4Medical Oncology, Vumc
CTMM DeCoDe
Imaging - Head and neck cancer
54. Detection of residual neck disease after chemoradiation by PET-CT
S. Hakim1, O.S. Hoekstra2, R. de Bree1
Department of 1Otolaryngology/Head-Neck Surgery, and 2Radiology & Nuclear Medicine, VU University Medical Center,
Amsterdam
55. Evaluation and prediction of response
C.S. Schouten1, O.S. Hoekstra2, J.A. Castelijns2, C.R. Leemans1, R. de Bree1
Departments. of 1Otolaryngology/Head and Neck Surgery, 2Radiology & Nuclear Medicine, 3Oral and Maxillofacial
Surgery, 4Pathology, VU University Medical Center
ZonMw and CCA 945-04-311, 80-82305-98-08106
56. FDG-PET for avoidance of futile direct laryngoscopies under general anasthesia with taking op biopsies in patiens with
suspicion on recurrent laryngeal carcinoma after radiotherapy
L. van der Putten1, I. van der Waal3, O.S. Hoekstra2, E. Bloemena4, C.R. Leemans1, R. de Bree
Depts. of 1Otolaryngology - Head and Neck Surgery, 2Radiology & Nuclear Medicine 3Oral and Maxillofacial Surgery,
4Pathology, VU University Medical Center, Amsterdam
ZonMw and CCA
57. Improvement of the sentinel node procedure in head and neck cancer by PET-CT lymfoscintigraphy, optical techniques
and minimal invasive surgery. Molecular targeting of intracellular proteins in cancer
D.H. Heuveling1, G.A.M.S. van Dongen1,2, A. van Schie2, O.S. Hoekstra2, C.R. Leemans1, R. de Bree1
Department 1Otolaryngology/Head and Neck Surgery, 2Radiology & Nuclear Medicine, VU University Medical Center,
Amsterdam
VUmc Cancer Center Amsterdam
58. Molecular targeting of intracellular proteins in cancer
D.H. Heuveling1, G.A.M.S. van Dongen1,2, C.R. Leemans1, R. de Bree1
Department of 1Otolaryngology/Head and Neck Surgery, 2Radiology & Nuclear Medicine, VU University Medical Center,
Amsterdam
59. PET tracers for (chemo)radiation of lung and head and neck cancer
A. Poot1, N.H. Hendrikse2,3, G.A.M.S. van Dongen1,2
Departments. of 1Otolaryngology/Head-Neck Surgery, 2Radiology & Nuclear Medicine and 3Clinical Pharmacology and
Pharmacy, VU University Medical Center,
CTMM Air Force
60. Response evaluation after chemoradiation for advanced oropharyngeal cancer using PET-CT and MRI
C.S. Schouten1, J.A. Castelijns2, O.S. Hoekstra2, R. de Bree1
Department of 1Otolaryngology/Head and Neck Surgery, 2Radiology & Nuclear Medicine, VU University Medical Center,
Amsterdam
ZonMw 171201005
61. Screening for distant metastases and second primary tumors with FDG-PET (The school study)
A. Senft1, J.A. Castelijns2, R. de Bree1, O.S. Hoekstra2, C.R. Leemans1
Depts. of 1Otolaryngology/Head and Neck Surgery, 2Radiology & Nuclear Medicine, VU University Medical Center,
Amsterdam
ZonMw Doelmatigheidsonderzoek 945-11-014
62. The predictive value of PET-DW-MRI early during chemoradiotherapy for locoregional control of advanced stage head and
neck cancer
D. Noij, C.S. Schouten, P. de Graaf, T. Marcus, J.Kuijer, M.Yaqub, R.Boellaard, O.Hoekstra, R. de Bree, J.A.Castelijns
Departments of Radiology & Nuclear Medicine, Otolaryngology/Head and Neck Surgery, VUmc, Amsterdam
63. Ultrasound guided fine needle aspiration cytology and sentinel node biopsy in the detection of occult lymph node
metastases of early oral and oropharyngeal cancer
G.B. Flach, I.J. den Toom, J. Castelijns, O.S. Hoekstra, A. van Schie, E. Bloemena, G.A.M.S. van Dongen, I. van der Waal,
C.R. Leemans, R. de Bree
Department Otolaryngology/Head and Neck Surgery, Radiology & Nuclear Medicine, VU University Medical Center,
Amsterdam
ZonMw 80-82305-98-08106
Imaging - Lung cancer
64. Quantification and tumor delineation with PET
I. Nissen1, FH van Velden1, M Yaqub1, OS Hoekstra1, EF Smit2, R Boellaard1
Departments of 1Radiology & Nuclear Medicine & 2Pulmonology, VU University Medical Center
CTMM AirForce
65. Validation of 112C-Erlotinib PETto personalize NSCLC therapy
I Bahce1, EF Smit1, Yaqub M2, AA Lammertsma2, NH Hendrikse2,3
Departments of 1Pulmonology, 2Radiology & Nuclear Medicine, 3Clinical Pharmacology and Pharmacy, VUmc
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -136
KWF
Imaging - Paediatric tumours
66. Development of pediatric brain tumor. Diffuse intrinxic pontine glioma (DIPG) models for improvement of imaging and
therapy
P. Wesseling1, T. Würdinger2, E. Hulleman3, G.J. Kaspers3
Departments of 1Pathology, 2Neurooncology Research Group, 3Pediatric Oncology/ Hematology, VU University Medical
Center, 4VU University RNC, 5Massachusetts General Hospital and Harvard Medical School, Boston, MA
Stichting Kika
Imaging - Retinoblastoma
67. Diagnosis, staging and follow-up of (trilateral) retinoblastoma
M. de Jong1, P. de Graaf1, H.J. Brisse MD2, P. Galluzzi3, S. Göricke4, Ph. Maeder5, A.C. Moll6, J.A. Castelijns1
1Dept. of Radiology, VU University Medical Center, Amsterdam,2Dept. of Radiology, Institut Curie, Paris, France, 3 Dept.
of Neuroimaging and Neurointerventional (NINT), Azienda Ospedaliera e Universitaria Santa Maria alle Scotte Siena, Italy ,
4Dept. of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany, 5 Dept. of
Radiology, University Hospital, Lausanne, Switzerland, 6Dept. of Ophtalmology, VU University Medical Center,
Amsterdam
68. Imaging of retinoblastoma: advanced MRI techniques and associated abnormalities
F. Rodjan1, P. de Graaf1, A.C. Moll2, P.J.W. Pouwels3, J.A. Castelijns1
1Department of Radiology & Nuclear Medicine, 2 Department of Ophthalmology, 3 Physics & Medical Technology, VU
University Medical Center, Amsterdam, The Netherlands
ODAS Foundation
Imaging - Rheumatoid diseases
69. Detection of subclinical synovitis with (R)-11C-PK11195 positron emission tomography in treated Rheumatoid Arthritis
patients without clinical synovitis
Y.Y.J. Gent, N. Ahmadi2, A.E. Voskuyl1, N.Hoetjes2, C. van Kuijk2, K. Bristsemmer3, F. Turkstra3, M. Boers4, O.S.
Hoekstra2, C.J. van der Lakenl1
Depts of 1Rheumatology, 2Radiology and Nuclear Medicine, and 4Clinical Epidemiology & Biostatistics, Amsterdam VU
University Medical Center, 3Department of Rheumatology, Jan van Breemen Research Institute Institute | Reade,
Amsterdam
70. Development of imaging markers, using PET(-CT), for early detection of RA and therapy monitoring
Y.Y.J. Gent1, K. Weijers1, I. de Greeuw2, M. Verlaan2, B. Windhorst2, A.A. Lammertsma2, O.S. Hoekstra2, B.A.C.
Dijkmans1, G. Jansen1, C.F.M. Molthoff2, C.J. van der Laken1
Departments. of 1Rheumatology, 2Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam
Proteomics - Brain tumours
71. Phosphoproteomics of glioblastoma cells: ΔEGFR targets and erlotinib effects
J.C. van der Mijn1*, R. Piersma2*, Thang V. Pham3, Tom Wurdinger3, H.M.W. Verheul1*, and Connie R. Jimenez2*
1Angiogenisis Laboratory, 2OncoProteomics Laboratory, Department of Medical Oncology, 3Department Neurosurgery,
VU University Medical Center, Amsterdam, the Netherlands. *Equal contribution.
VUmc Cancer Center Amsterdam and the Moller Foundation
Proteomics - Breast cancer
72. Immunohistochemical validation in human breast cancer of selected protein members of the mouse 45 protein BRCA1
deficiency signature
P. van der Groep1,2, M. Warmoes3, J. Lam3, Y. Smolders2, E. Boven3, S. Rottenburg4, J. Jonkers4, E. van der Wall1, P.
van Diest2, C. Jimenez3
1Division of Internal Medicine and Dermatology and 2Department of Pathology, University Medical Center Utrecht,
Utrecht, 3Oncoproteomics Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam,
4Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
73. PI3K pathway analysis in tumor tissue and circulating DNA to obtain further insight in the efficacy of evarolimus in
combination with exemestane in postmenopausal patients with hormone receptor-positive advanced metastatic breast
cancer, who have progressed on anastrozole or letrozole
D.T. Kruger1, S. Linn2, S. Sleijfer3, C. Jimenez4, E. Boven1. In cooperation with Dutch Breast Cancer Trialists' Group,
Amsterdam
1Dept of Medical Oncology, VU University Medical Center. 2NKI-AvL, Amsterdam. 3Erasmus Medical Center, Rotterdam.
4Head of OncoProteomics Laboratory, VU University Medical Center
74. Proteomics of mouse BRCA1-deficient and proficient mammary cell line secretomes reveals candidate biomarkers for
non-invasive testing
M. Warmoes¹*, S.W. Lam1*, T.V. Pham1, S.R. Piersma1, S. Rottenberg2, E. Boven1, P. van der Groep3, P.J. van Diest3, P.
Nederlof2, J. Jonkers2, C.R. Jimenez1
1 Oncoproteomics Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, The
Netherlands; 2 Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands;
3Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands. *Equal contribution.
VUmc Cancer Center Amsterdam
Proteomics - Colorectal cancer
75. Chromatin-associated proteins in colorectal adenoma and carcinoma tissues
J.C. Knol1, J. Albrethsen1, T.V. Pham1, S.R. Piersma1, S. Mongera2, B. Carvalho2, M. de Wit2, R.J.A. Fijneman2, G.A.
Meijer2, and C.R. Jimenez1
1OncoProteomics Laboratory, Department Medical Oncology, 2Department Pathology, VU University Medical Center,
Amsterdam. The Netherlands
VUmc-Cancer Center Amsterdam
76. Colorectal cancer tissue spheroids: an in-depth proteomics analysis
U. Rajcevic1, J.C. Knol2, S. Piersma2, S. Bougnaud1, T.V. Pham2, E. Sundlisaeter3, P. Enger3, R. Bjerkvig1,3, S.P. Niclou1
and C.R. Jimenez2
1NorLux Neuro-Oncology, CRP-Santé, Luxembourg, 2OncoProteomics Laboratory, Department Medical Oncology, VU
University Medical Center, Amsterdam; 3Department of Biomedicine, University of Bergen, Bergen, Norway
Fonds National de la Recherche (FNR) of Luxembourg and the VUmc Cancer Center Amsterdam
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -137
77. Deciphering signaling pathways in a panel of colorectal cancer cell lines by label-free titanium-oxide-based
phosphoproteomics
B.K. Sampadi1, S.R. Piersma1, M. Labots2, J.A.C.M. Goos3, B. Carvalho3, G.A. Meijer3, R.J.A. Fijneman3, H.M.W. Verheul2,
C.R. Jimenez1
1Oncoproteomics Laboratory, Dept. Medical Oncology, 2Angiogenesis laboratory, Dept. Medical Oncology; 3Tumor
Profiling Unit, Dept. Pathology, VU University Medical Center, Amsterdam, The Netherlands
VUmc Cancer Center Amsterdam
78. Proteome profiling of proximal fluids from human colon cancer tissue reveals novel candidate biomarkers for early
diagnosis
M. de Wit1,2, H. Kant2, S. Piersma2, T. Pham2, S. Mongera1, M.P.A. van Berkel2, E. Boven2, G.A. Meijer1, R.J.A.
Fijneman1**, C.R. Jimenez2***Shared corresponding authors
1Department of Pathology (Tumor Profiling Unit), 2Department of Medical Oncology, VU University Medical Center,
Amsterdam, the Netherlands.*Shared last author
Aegon International Scholarship in Oncology, VUmc-Cancer Center Amsterdam
79. Proteomics of colorectal metastase tissue: high expression of serpinB5 (Maspin) is associated with poor survival in stage
III and IV colorectal cancer
Snoeren N1*, Emmink BL1*, Goos JA3, Piersma SR2, de Wit M3, Pham TV2, Belt EJ4, Bril H5, Stockmann HB6, Fijneman
RJ3, Meijer GA3, Jimenez CR2, Kranenburg O1, Borel Rinkes IHM1
1 Department of Surgery, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands, 2
Department of Medical Oncology VU University Medical Center, De Boelelaan 1117, 1081HV, The Netherlands, 3
Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands, 4
Department of Surgery, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands, 5
Department of Pathology, Kennemer Gasthuis, Boerhaavelaan 22, 2035 RC Haarlem, The Netherlands, 6 Department of
Surgery, Kennemer Gasthuis, Boerhaavelaan 22, 2035 RC Haarlem, The Netherlands
80. Proteomics of exosomes secreted by cancer cell lines and primary cells reveals oncogenic signaling and biomarker
potential
M. de Wit1, R.J.A. Fijneman2 , M. Lavaei1, H. de Wit3, J. van de Wetering3, J.C. Knol1, S.R. Piersma1, T.V. Pham1, R.
Steenbergen2, G.A. Meijer2, H.M.W. Verheul1, M. Pegtel2, C.R. Jimenez1
1Dept. Pathology, 2Dept. Medical Oncology, 3NCA-VU, VU University Medical Center
VUmc-Cancer Center Amsterdam
Proteomics - Colorectal cancer
81. Stool proteomics reveals novel candidate biomarkers for colorectal cancer screening
L.J.W. Bosch1*, M. de Wit2*, G. Oudgenoeg2, A.C. Hiemstra1, S. Mongera1, S.R. Piersma2, T.V. Pham2, J.S. Terhaar sive
Droste3, F.A. Oort3, S.T. van Turenhout3, I. Ben Larbi3, C.J.J. Mulder3, B. Carvalho1, C.R. Jimenez2, R.J.A. Fijneman1,
G.A. Meijer1 *These authors have contributed equally to this work.
1Department of Pathology, 2Medical Oncology and 3Gastroenterology and Hepatology, VU University Medical Center,
Amsterdam, The Netherlands
VUmc Cancer Center Amsterdam and CTMM-DeCoDe
Proteomics - Generic
82. Label-free phosphoproteomics: evaluation of workflow performance at normal and low protein input levels
M. Labots1, K. van der Mijn1, S. Piersma2, R. de Haas1, I. de Reus2, J. Knol2, T. Pham2, N. van Grieken3, G. Meijer3,
H.M.W. Verheul1, C. Jiménez2
1Department of Medical Oncology, VU University Medical Center, 2OncoProteomics Laboratory, Department of Medical
Oncology, VU University Medical Center, 3Department of Pathology, VU University Medical Center
VUmc Cancer Center Amsterdam
83. Pilot study on the determination of intratumoral concentrations of kinase inhibitors in patients with advanced solid
malignancies (ICK)
M. Labots, M. Neerincx, J. van der Mijn, G. Peters, H.M.W. Verheul et al
Department of Medical Oncology, VU University Medical Center Amsterdam
Proteomics - Hematology
84. Phosphoproteomics for personalized treatment of acute myeloid leukemia with kinase inhibitors
J.J.W.M. Janssen*, C. van Alphen, J. Cloos, G.J. Schuurhuis, G.J. Ossenkoppele, H.M.W. Verheul, C.R. Jimenez*
Department of Hematology and Medical Oncology, VU University Medical Center
Stichting VUmc CCA
85. Phosphoproteomics for personalized treatment of acute myeloid leukemia with kinase inhibitors
C. van Alphen1, J. Cloos1, G. Ossenkoppele1, G.J. Schuurhuis1, H.M.W. Verheul2, C. Jimenez2*, J. Janssen1*.
1.Dept. Hematology; 2. Dept. Medical Oncology of the VU University Medical Center. *shared senior authors
VUmc Cancer Center Amsterdam
86. Protein Composition of exosomes yields new insights into the endosomal-exosomal pathway of B cells during infection
and malignant transformation
D. Koppers-Lalic1, J. Knol2, T.V. Pham2, F. Verweij1, S. Piersma2, J. Middeldorp1, C.R. Jimenez2*, M. Pegtel1* *Shared
corresponding authors
1Dept. of Pathology, VUmc, 2OncoProteomics Laboratory, Dept. Medical Oncology, VU University Medical Center
VUmc Cancer Center Amsterdam
87. Transfer of regulatory protein networks via extracellular vesicles as a possible mechanism of AML resistance to apoptosis
A. Wojtuszkiewicz1,2, F. Kessler2, S. Zweegman2, G.J. Schuurhuis2, G. Jansen3, S. Piersma4, J. Knol4, Y.G. Assaraf5,
G.J.L. Kaspers1, J. Cloos1,2, C.R. Jimenez4
1Dept of Pediatric Oncology/Hematology, 2Dept. of Hematology, 3Dept. of Rheumatology, 4Dept. of Medical Oncology
VU University Medical Center, The Netherlands, 5Dept. of Biology, Technion-Israel Institute of Technology, Haifa, Israel
VUmc Cancer Center Amsterdam
Proteomics - Lung cancer
88. Novel candidate biomarkers for cisplatin response prediction and monitoring in NSCLC
T.B.M. Schaaij-Visser1, N. Proost2, R. Nagel3, S.R. Piersma1, T.V. Pham1, R.H. Brakenhoff3, F.B.J.M. Thunissen4, E.F.
Smit5, A. Berns2, C.R. Jimenez1
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -138
1OncoProteomics Laboratory, Department of Medical Oncology, 2Division of Molecular Genetics and Centre for
Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands; 3Department of
Otolaryngology/Head and Neck Surgery, 4Department Pathology, 5Department Pulmonology, VU University Medical
Center, Amsterdam, The Netherlands
CTMM Airforce
Proteomics - Prostate cancer
89. From prostate cancer cell exosome proteomics to urine-based biomarkers
I.V. Bijnsdorp1*, A.A. Geldof1, M. Lavaei2, S.R. Piersma2, R.J.A. van Moorselaar1, C.R. Jimenez2
1. Department of Urology;2. OncoProteomics Laboratory, Department of Medical Oncology, VU University Medical Center,
Amsterdam, The Netherlands
VUmc Cancer Center Amsterdam
Rheumatology
90. Acceleration, synchronisation and validation of experimental spondyloarthritis in HLA-B27+huB2m++ transgenic rats
L. van Duivenvoorde1, I. de Greeuw2, M. Verlaan2, R. Bergstra2, J. van der Laken3, C.F.M. Molthoff2
1Dept. of Reumatology, AMC medical center, 2Dept. of Radiology&Nuclear Medicine and 3Reumaotology, VUmc
Amsterdam
AMC
91. B cells in the preclinical phase of rheumatoid arthritis
S. Ozturk, C.L. Verweij
Department of Pathology, VU University Medical Center Amsterdam
Reumafonds
92. Cross-regulation between TNF and IFN in rheumatidc arthritis
T.D. de Jong1, S. de Ridder1, J. Beliën1, P. Welsing2, J. Luime3. C. Verweij1
1Department of Pathology, 2UMCU, 3Emc
CTMM Reumafonds
93. Development of Tools (and prediction rules) to time and select therapy in treatment of pre-clinical, early, and established
Rheumatoid Arthritis: Creating Enhanced Remedy (TRACER)
J. Lübbers1, C. Verweij
1Department Of Pathology, VU University Medical Center, Amsterdam
94. Gene signatures in autoimmunity
M. Blits, M. Pegtel. C.L. Verweij
Department of Pathology, VU University Medical Center Amsterdam
95. Personalized Medicine in the treatment of rheumatoid arthritis
C.L. Verweij
Department of Pathology, VU University Medical Center Amsterdam
VUmc Cancer Center Amsterdam
96. TRACER Protein arrays and metabolite biomarkers to predict development of RA and response to therapy (WP8)
J. Wesseling, A.E. Voskuyl, P. van der Putte, C. Verweij
Dept. of Pathology, Dept. of Rheumatology, Flexgen
CTMM
97. Understanding the molecular basis of the differential INFB response in relapsing remitting MS
S. Vosslamber, C.T.M. van der Pouw Kraan, M. Pegtel, A.E. Voskuyl, C.L. Verweij
Department of 1Pathology, 2 Neurology, VU University Medical Center Amsterdam
MS stichting
Other
98. Assessing the need for isolation in a single room of patients colonized with highly resistant microorganisms
C.M.J.E. Vandenbroucke-Grauls, J.A.J.W. Kluytmans
Department of Medical Microbiology and Infection Control, VU University Medical Center
ZonMw
99. Carbapenemase-producing Enterobacteriaceae in The Netherlands: development of phenotypical and molecular assays
for detection and evaluation of the prevalence, risk factors and molecular epidemiology
J.A.J.W. Kluytmans, C.M.J.E. Vandenbroucke-Grauls
Department of Medical Microbiology and Infection Control, VU University Medical Center
ZonMw
100. Crypton I: A genome-based generalized strategy to activate cryptic antibiotic biosynthesis gene clusters in
Actinomycetales
C.M.J.E. Vandenbroucke-Grauls, W. Bitter
Department of Medical Microbiology and Infection Control, VU University Medical Center (samenwerking met RUG)
STW Genbiotics grant
101. Crypton II: Continuation of Crypton I A genome-based generalized strategy to activate cryptic antibiotic biosynthesis
gene clusters in Actinomycetales
C.M.J.E. Vandenbroucke-Grauls, W. Bitter
Department of Medical Microbiology and Infection Control, VU University Medical Center (samenwerking met RUG)
STW Genbiotics grant (continuation of Crypton I)
102. CTMM algemeen
M. van Engeland1, C.J.H. van de Velde2, G.A. Meijer2
Department of Pathology, MUMC1, VU University Medical Center Amsterdam2
CTMM
103. Diagnostic monitoring of NPC and building a second center of expertise in Indonesia
Gondowiyardjo S1, L. Adham1, A.N. Kurniawan1, J.M. Middeldorp2
1Univ Indonesia, Jakarta, 2Department of Pathology, VU University Medical Center, Amsterdam
KWF
104. ICT and data analysis
J. Beliën, G.A. Meijer
Department Of Pathology, VU University Medical Center, Amsterdam
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -139
CTMM
105. Identifying the epileptogenic zone in the absence of epileptiform discharges: bias-free network analysis applied to
interictal MEG recordings
I. Nissen1,2, E. van Dellen1, L. Douw1, J.J. Heimans1, J.C. Baayen4, P.C. de Witta Hamer3, G. Visser5, C.J. Stam2, J.C.
Reijneveld1,4 A. Hillebrand2
Departments of 1Neurology, 2Clinical Neurophysiology, 3Neurosurgery, VU University Medical Center, 4Department of
Neurology, Academic Medical Center, Amsterdam, 5Department of Clinical Neurophysiology, Stichting Epilepsie
Instellingen Nederland (SEIN), Heemstede
Epilepsie Fonds NEF 14-16
106. Leukoplakie, histopathological, epidemiological and clinical analysis
E. Brouns, E. Bloemena
Department Of Pathology, VU University Medical Center
MKZ
107. Medical technology assessment
C. Uyl, V. Coupé, G.A. Meijer
Department Of Pathology, VU University Medical Center, Amsterdam
CTMM
108. Multiplex NPC families in Taiwan
A. Hildesheim2, J.M. Middeldorp1
1Department Of Pathology, VU University Medical Center Amsterdam, 2 NCI-NIH, USA
RTI, USA
109. Pathogen Trace
P. Savelkoul
Department Medical Microbiology and Infection Control, VU University Medical Center Amsterdam
EU-FP7
110. TRACER ICT
S. de Ridder, J. Beliën, C. Verweij
Department of Pathology and Reumatology, VU University Medical Center Amsterdam
111. Validation of citrulline as a marker of small intestine absorption capacity: a pilot study
J.H.C. Peters1, N.J. Wierdsma2, C.J.J. Mulder1, P.A.M. van Leeuwen3 and A.A. van Bodegraven1
1Department of Gastroenterology, Small Bowel Disease Unit, 2Department of Nutrition and Dietetics, 3Department of
Experimental Surgery, VU University medical center, Amsterdam, the Netherlands
Program 4
Angiogenesis
1. Exploring the role of endothelial galectins in tumor angiogenesis
I. Schulkens1, A.W. Griffioen1, V.L.J.L. Thijssen1,2
Departments. of 1Medical Oncology, VU University Medical Center, 2Radiotherapy, VU University Medical Center
KWF 2009-4358
Brain cancer
2. Cross-talk in the brain tumor micro-environment: microRNAs and microvesicles
M. Smits1,2, S. van Rijn1,2 , P. van der Stoop1,2, J. Berenguer1,2, W.P. Vandertop1,2, D.P. Noske1,2, T Wurdinger1,2,3
Departments. of 1Neurosurgery, 2Neuro-oncology Research Group, VU University Medical Center, Amsterdam.
3Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA
NWO-VIDI, Van Reekum/van Moorselaar stichting, CCA/STR, Swedish Research Council
3. Developing in vitro and in vivo models of diffuse intrinsic pontine glioma (DIPG) and pre-clinical testing of novel
therapies
A.C.P. Sewing1,4, T. Lagerweij 4, D Biesmans 4, SEM Veldhuijzen van Zanten1, D Noske 2.4, P. Wesseling 3,4, D.G. van
Vuurden1,4, T. Wurdinger, G.J.L. Kaspers1, E. Hulleman 1,4
Departments of 1Pediatric oncology, 2Neurosurgery, 3Pathology 4Neuro-oncology Research Group Cancer Center
Amsterdam, VU University Medical Center Amsterdam
KiKa
4. Development of novel treatment options targeting invasive malignant glioma cells
P. van der Stoop, V.W. van Beusechem, T. Wurdinger, D. Noske
Department of Neurosurgery and Medical Oncology, VU University Medical Center, Amsterdam
VIDI grant Tom Wurdinger
5. Drug distribution and local drug delivery in diffuse intrinsic pontine glioma
S.E.M. Veldhuijzen van Zanten, D.G. van Vuurden, M.H.A. Jansen, W.P. Vandertop, G.J.L. Kaspers
1Pediatric Oncology/ Hematology, VU University Medical Center, Amsterdam, The Netherlands; 2 Neurosurgical Center
Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
Stichting Semmy
6. Gemcitabine and PI3Kinase-Akt pathway inhibition to enhance radiotherapy in human glioblastoma multiforme (GBM)
M El-Naggar, C Fedrigo, P. Sminia, GJ Peters
Department Of Medical Oncology and Radiation Oncology, VU University Medical Center, Amsterdam
7. Growth factors as a target for the treatment of diffuse intrinsic pontine glioma
J. Janzen1,2, D.G. van Vuurden1,2, G.J.L. Kaspers1, E. Hulleman1,2
Department of 1Pediatric oncology / 2Neuro-oncology Research Group Cancer Center Amsterdam, VU University Medical
Center Amsterdam
Stichting Semmy
8. Monitoring of treatment response to EGFRvIII-targeted treatment in patients with glioblastoma through blood profiling
N. Sol1,2, T. Würdinger2, H.M.W. Verheul3, J.J. Heimans1, B. Ylstra4, P. Wesseling4, J.C. Reijneveld1,3
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -140
Departments of 1Neurology, 2Neurosurgery, 3Medical Oncology and 4Pathology, VU University Medical Center,
Amsterdam, Department of 5 Neurology, Academic Medical Center, Amsterdam
KWF Kankerbestrijding VU 2013-5751
9. Prediction of response to radiotherapy with concomitant and adjuvant Temozolomide in glioblastoma patients with
serum proteomics
M.E. Van Linde1, J.C. van der Mijn1, T.V. Pham1, J.C. Knol1, L.E. Wedekind3, J. Buter1, T. Wurdinger3, C.R. Jimenez1, J.C.
Reijneveld2, H.M.W. Verheul1
Departments. of 1Medical Oncology, 2Neurology and 3Neurosurgery of the VU University Medical Center Amsterdam
10. Targeted therapy in pediatric brain tumors
D.G. van Vuurden1,4, E. Hulleman2,4, P. van der Stoop2,4, T. Wurdinger2,4, M. Irandoust1,3, G.J.L. Kaspers1, J. Cloos1,3
Departments of 1Pediatric Oncology/ Hematology, 2Neurosurgery, 3Hematology and 4Neuro-Oncology Research Group,
VU University Medical Center, Amsterdam
VONK
11. Treatment strategies and new diagnostic tools for malignant pontine gliomas
M.H.A. Jansen1, D.G. van Vuurden1, W.P. Vandertop2, G.A.M.S. van Dongen3,4, O.S. Hoekstra4, G.J.L. Kaspers1
1Department Pediatrics, Pediatric Oncology/-Hematology, 2Department Neurosurgery, 3Department
Otolaryngology/Head and Neck Surgery and 4Radiology & Nuclear Medicine, 4Department Nuclear Medicine, VU
University Medical Center, Amsterdam
Semmy Foundation
12. Unravelling diffuse pontine glioma
E. Hulleman1,2, P.J. van der Spek3, G.J.L. Kaspers1
Department of 1Pediatric oncology / 2Neuro-oncology Research Group Cancer Center Amsterdam, VU University Medical
Center Amsterdam, 3 Bioinformatics Center ErasmusMC, Rotterdam
Complete Genomics
Colorectal cancer
13. A phase I study of SGI-110 combined with irinotecan followed by a randomized phase II study of SGI-110 combined with
irinotecan versus regorafenib in previously treated metastatic colorectal cancer patients (CORSICA)
E. Gootjes, N. Ahuja, I. Browner, D. Cosgrove, L. Diaz, A. de Jesus Acosta, R. Donehower, D. Laheru, D. Le, K. McIntyre, E.
Petito, Z. Rasheed, L. Zheng, A. el-Khoueiry, H.M.W. Verheul, N. Azad
Department of Medical Oncology, VU University Medical Center, Amsterdam
14. Individualized treatment of patients with advanced colorectal cancer based on miRNA expression profiling
M. Neerincx, D. Poel, T. Buffart, G.A. Meijer, B. Ylstra, M. v.d. Wiel, D. Sie, H.M.W. Verheul
Department of Medical Oncology VU University Medical Center Amsterdam
15. Innovations in local treatment and imaging of colorectal liver metastases
K. Nielsen1, H.J. Scheffer2, M.P. van den Tol1, E.F.I. Comans2, M.R. Meijerink2, S. Meijer1
Departments of 1Surgery, 2Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam
Donation
16. Radiosensitization by TAS-102 in colorectal cancer
M. El-Naggar1,4, J. van den Berg 2, I. Bijnsdorp3, P. Sminia2, G.J. Peters4
1Assiut University Hospital, Egypt; Departments of 2Radiation Oncology and 3 Urology 4Medical Oncology, VU
UniversityMedicalCenter, Amsterdam, The Netherlands
17. Treatment optimization of cetuximab in patients with metastatic colorectal cancer based on tumor uptake of 89Zrlabeled cetuximab assessed by PET
C. Menke, E. Gootjes, E. van Helden, G.A.M.S. van Dongen, O.S. Hoekstra, H.M.W. Verheul
Department of Medical Oncology and Radiology and Nuclear Medicine, VU University Medical Center Amsterdam
Gastroenterology
18. Absorptiometry in health and disease
N.J. Wierdsma1, M.A.E. van Bokhorst-van der Schueren1, C.J.J. Mulder2, A.A. van Bodegraven2
1Department of Nutrition and Dietetcs and 2Department of Gastroenterology, Small Bowel Disease Unit, VU University
Medical Center, Amsterdam
19. Immunogenetic and therapeutic aspects of autoimmune hepatitis
N.M.F. van Gerven1, B.J. Verwer1, Y.S. de Boer1, C.J.J. Mulder1, E. Bloemena2, G. Kraal3, C.M.J. van Nieuwkerk1, G.
Bouma1
1. Department of Gastroenterology and Hepatology, VU University Medical Center, 2. Department of Pathology, VU
University Medical Center, 3. Department of Molecular Cell Biology and Immunology, VU University Medical Center
Head and neck cancer
20. Detection of tumour recurrence in H&N cancer patients who are treated with chemoradiotherapy: comparison of PET and
MRI
V.Jagesar , P. de Graaf, O.Hoekstra, R. de Bree, J.A.Castelijns
Departments of Radiology & Nuclear Medicine, Otolaryngology/Head and Neck Surgery, VUmc
21. Electrochemotherapy
D.H. Heuveling, C.R. Leemans, R. de Bree
Department of Otolaryngology/Head and Neck Surgery VU University Medical Center, Amsterdam
IGEA
22. Epstein barr virus activation and cytolytic antivirual therapy in nasopharyngeal patients
O. Ramayanti1, A.E. Greijer1, I.B. Tan2, J. Kurnianda3, J.M. Middeldorp1
1Department of Pathology, VU University Medical Center, 2Department Of Head and Neck Surgery & Medical Oncology,
NKI, Amsterdam, 3Department Medicine, Gadjah Mada University
KWF VU 2010-4809
23. Hypothyroidism after treatment for laryngeal cancer
A.M. Lo Galbo, R. de Bree, C.R. Leemans
Department Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam
24. Improvement of treatment of head and neck cancer. General aspects
R. de Bree1, D.A. Heuveling1, S. Hakim1, C.S. Schouten1, S. van Weert1, P. Doornaert2, K.H. Karagozoglul3, J. Buter4 ,
O.S. Hoekstra5, J.A. Castelijns5, C.R. Leemans1
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -141
Depts. of 1Otolaryngology-Head and Neck Surgery, 2Radiation Oncology, 3Oral and Maxillofacial Surgery, 4 Medical
Oncology, 5 Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam
ZonMw
25. MRI characteristics of Whartin tumours
F.Alberts , R.Ljumanovic, P. de Graaf, O.Hoekstra, R. de Bree, J.A.Castelijns
Departments of Radiology & Nuclear Medicine, Otolaryngology/Head and Neck Surgery, VUmc
26. New therapy for Epstein-Barr virus driven tumours by targeting the virus itself
Z. Novalic1, A.E. Greijer1, I.B. Tan2, J.P. de Boer2, J.M. Middeldorp1
1Department of Pathology, VU University Medical Center, 2Department Of Head and Neck Surgery & Medical Oncology,
NKI, Amsterdam
ZonMw
27. Salvage treatment after (chemo)radiation
L. van der Putten, C.R. Leemans, R. de Bree
Department of Otolaryngology/Head and Neck Surgery VU University Medical Center, Amsterdam
Hematology
28. Application of bortezomib in pediatric acute lymphoblastic leukemia
D. Niewerth1,2, J. van Meerloo1, S. Zweegman2, G.J.L. Kaspers1, G. Jansen3, J. Cloos1,2
Departments. of 1Pediatric Oncology/Hematology, 2Hematology and 3Rheumatology, VU University Medical Center,
Amsterdam
Stichting KIKA
Hematology
29. Characterization of relapsed acute myeloid leukemia
C. Bachas1,2, Z.J. Kwidama1,2, G.J. Schuurhuis2, G.J.L. Kaspers1 J. Cloos1,2.
Departments. of 1Pediatric Oncology/ Hematology and 2Hematology, VU University Medical Center, Amsterdam
KWF KWF 2005-3666
30. Clonal evolution of acute myeloid leukemia stem cells
R. Wouters1,2, C. Bachas1,2, Z.J. Kwidama1,2, E. Sonneveld3, L. Smit2, G.J. Ossenkoppele2, G.J.L. Kaspers1 G.J.
Schuurhuis2, J. Cloos1,2.
Departments. of 1Pediatric Oncology/ Hematology and 2Hematology, VU University Medical Center, Amsterdam, 3Dutch
Childhood Oncology Group, The Hague
VONK
31. Drug resistance in childhood leukemia
N.E. Franke1, J. van Meerloo1,2, D Niewerth1,2, S.E. Verbrugge3, R.X. de Menezes4, W.J. Chng6, B.A.C. Dijkmans3, Y.G.
Assaraf7, G.J.L. Kaspers1, G. Jansen3, J. Cloos1,2
Depts. of 1Pediatric Oncology/Hematology, 2Hematology, 3Rheumatology and 4Epidemiology and Biostatistics , VU
University Medical Center, Amsterdam, 4Dept. of Medicine, National University of Singapore, 7Dept of Biology, TechnionIsrael Institute of Technology, Haifa, Israel
Stichting Translation Research and ZonMw PV06/08 CCA
32. EUTOS project: (European Treatment and Outcome Study)
N. Thielen, J.J.W.M. Janssen, G.J. Ossenkoppele
Department of Hematology, VU University Medical Center
33. Identification of targeted therapies for anaplastic large cell lymphoma based on apoptosis expression profiles
C.J.L.M. Meijer, G.J. Ossenkoppele, S. Cillessen
Department of Pathology en Hematology, VU University Medical Center, Amsterdam
KWF 2010-4704
34. Improvement of diagnosis and treatment of childhood leukemia in Indonesia
P.H. Widjajanto1, E. Supriyadi1, J. Cloos2,3, Y. Nency4, S. Gunawan5, S. Mostert2, M.N. Sitaresmi1, G.J.L. Kaspers2,
Sutaryo1, A.J.P. Veerman2
1Department of Pediatrics, Dr Sardjito Hospital, Gadjah Mada University, Yogyakarta, Indonesia; 2Departments of
Pediatric Oncology/Hematology and 3Hematology, VU University Medical Center, Amsterdam, 4Department Pediatrics, dr
Kariadi Hospital, Un. Diponegoro, Semarang, 5Department of Pediatrics dr Kandou Hospital, Un Sam Ratulangi, Manado
Dutch Cancer Society grant IN 2006-22
35. Improvement of diagnosis of childhood leukemia in the Yogyakarta special region in Indonesia
E. Supriyadi1, A.J.P. Veerman2, Purwanto1, P.H. Widjajanto1, S. Mostert2, M.N. Sitaresmi1, Sutaryo1, J. Cloos2,3.
1Department of Pediatrics, Dr Sardjito Hospital, Gadjah Mada University, Yogyakarta, Indonesia; 2Departments of
Pediatric Oncology/Hematology and 3Hematology, VU University Medical Center, Amsterdam
KWF IN-2006-22
36. PET-CT of biodistribution of rituximab in relation to therapeutic outcome and histological response of lymphoid tissue in
rheumatoid arthritis patients
S.T. Bruijnen1, A.E. Voskuyl1, G. Jansen1, G.A.M.S. van Dongen2, M.C. Huisman2, O.S. Hoekstra2, A.A. Lammertsma2,
P.P. Tak3, Boumans J.H.M., C.J. van der Laken1.
Departments of 1Rheumatology, 2Radiology & Nuclear Medicine, VU University Medical Center, Department of
Rheumatology & Immunology3, Academic Medical Center, Amsterdam
37. Prediction of achievement of deep molecular responses to combination treatment with nilotinib and pegylated interferonalpha in chronic myeloid leukemia
J.J.W.M. Janssen, M. Koppes, G.J. Schuurhuis, G.J. Ossenkoppele
Department of Hematology, VU University Medical Center
Novartis Netherlands
38. Predictive value of stem cell enumeration for the response to nilotinib in newly diagnosed CML patients
N. Thielen, A. Zevenbergen, B. van Kuijk, W. Pouwels, G.J. Schuurhuis, G.J. Ossenkoppele, J.J.W.M. Janssen
Department of Hematology, VU University Medical Center
Novartis
39. Target identification specific for leukemic stem cells of acute myeloid leukemia
H. Verhagen1, D. de Leeuw1, F. Denkers1, P. Celie2, R. Kerkhoven3, I. de Rink3, M. Terwijn1, A. Rutten1, W. Pouwels1, B.
Ylstra4, R. Menezes5, G. Ossenkoppele1, G.J. Schuurhuis1 and L. Smit1
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -142
1Department of Hematology, 4Department of Pathology, 5Department of Biostatistics, Cancer Center Amsterdam, VU
University Medical Center, Amsterdam, The Netherlands.2Protein facility, 3Genomics Core Facility, The Netherlands
Cancer Institute, Amsterdam, The Netherlands
VUmc Cancer Center Amsterdam
40. The identification of microRNAs specific for leukemic stem cells in acute myeloid leukemia
D. de Leeuw1, F. Denkers1, K. A. Rutten1, W. Pouwels1, R.Kerkhoven2, I de Rink2, P. de Palma3, P. Valk4, R. Menezes5,
C. Jimenez6, G.J. Schuurhuis1, G. Ossenkoppele1, L. Smit1
1Department of Hematology, 5Department of Biostatistics, 6Proteomic Facility, Cancer Center Amsterdam, VU University
Medical Center, Amsterdam, The Netherlands. 2Genomics Core Facility, The Netherlands Cancer Institute, Amsterdam,
The Netherlands, 3Institut Suisse de RechercheExperimentalesur le Cancer ( ISREC), Lausanne, Swiss. 4Department of
Hematology, Erasmus University, Rotterdam, The Netherlands
AICR and Interna
41. The role of impaired FPGS splicing in methotrexate response in childhood acute lymphoblastic leukemia
A.M. Wojtuszkiewicz1,2, G.J. Peters3, G. Jansen4, Y.G. Assaraf5, G.J.L. Kaspers1, J. Cloos1,2
2Depts. of 1Pediatric Oncology/Hematology, 2Hematology, 3Medical Oncology and 4Rheumatology, VU University
Medical Center, Amsterdam, 5Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel
Stichting KIKA (kinderen kankervrij)
42. The role of minimal residual disease, and leukemic stem cells herein, in clinical decision making
W. Zeijlemaker, G.J. Ossenkoppele, GJ. Schuurhuis
Department Of Hematology, VU University Medical Center, Amsterdam
Hematology Foundation
43. The therapeutic potential of IGF1R inhibition and IGFBP7 in the specific eradication of leukemic stem cells in acute
myeloid leukemia
H. Verhagen1, D. de Leeuw1, F. Denkers1, P. Celie2, R. Kerkhoven3, I. de Rink3, M. Terwijn1, A. Rutten1, W. Pouwels1, B.
Ylstra4, R. Menezes5, G. Ossenkoppele1, G.J. Schuurhuis1 and L. Smit1
1Department of Hematology, 4Department of Pathology, 5Department of Biostatistics, Cancer Center Amsterdam, VU
University Medical Center, Amsterdam, The Netherlands.2Protein facility, 3Genomics Core Facility, The Netherlands
Cancer Institute, Amsterdam, The Netherlands
VUmc Cancer Center Amsterdam
44. Therapeutic targeting of EVI-1 positive acute myeloid leukemia stem cells
B. Venniker-Punt, H. Verhagen, D. de Leeuw, A. Rutten, P. Merle, G. Ossenkoppele, G.J. Schuurhuis, L. Smit
Department of Hematology University Medical Center, Amsterdam, The Netherlands
St. Vu Steunfonds Hematologie
45. Treatment and survival of indolent and aggressive NHL patients; population based studies in the Netherlands
D.E. Issa, M. Wondergem, O. Visser, J.M. Zijlstra, M.E.D. Chamuleau, P.C. Huijgens, S. Zweegman
Department of Hematology, VU University Medical Center
Immunotherapy
46. A phase I open-label clinical trial, evaluating the therapeutic vaccine hVEGF-trunc/PEP-A10 in patients with advanced solid
tumors
M.Q. Wentink, A.W. Griffioen, T.D. de Gruijl, P.Timmerman, J.J van der Vliet, H.M.W. Verheul
Department of Medical Oncology, VU University Medical Center Amsterdam
47. Development of DCOne and novel AML-derived cell lines for DC-based allogeneic tumor vaccination
J.M. Ruben1, N. Kerkhoff1, W. Van den Ancker1, S.J.A.M. Santegoets2, M. Koppes1, P.J.G.T.B. Wijnands3, A. Reurs3, M.
Meerendonk3, J. Kaspers3, S. van Wetering3, A.J.M. van den Eertwegh2, Rik J. Scheper2,4, G.J. Ossenkoppele1, A.M.
Kruisbeek3, A.A. van de Loosdrecht1, T.D. de Gruijl2
Departments of 1Hematology, 2Medical Oncology, 3DC Prime BV, and the Department of 4Pathology, VU University
Medical Center, Amsterdam, The Netherlands
ZonMW Translationeel Research Grant, DCPrime BV 40-41200-98-9106
48. Immune correlates of clinical response and survival in castration resistant prostate cancer patients treated with Prostate
GVAX and anti-CTLA4 immunotherapy
S.J.A.M. Santegoets2, A.J.M. van den Eertwegh1, A.G.M. Stam2, S.M. Lougheed1, H. Gall1, P.E.T. Scholten2, B.M.E. von
Blomberg2, E. Hooijberg2, K. Jooss4, N. Sacks4, K. Hege4, I. Lowy5, R.J. Scheper2, W.R. Gerritsen1, T.D. de Gruijl1
Departments of 1Medical Oncology and 2Pathology of the VU University medical center, Amsterdam, The Netherlands;
3Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA; 4Cell Genesys Inc.,South San
Francisco, CA; 5Medarex, Bloomsbury, NJ
Prostate Cancer Foundation Research Award, Dutch Cancer Society KWF-VU 2006-3697
49. Immunomodulation of the sentinel lymph node
K.M. van Pul1, R. van de Ven1, B.D. Koster1, M.F.C.M. van den Hout2, B.J.R. Sluijter3, S.M. Lougheed1, S.J.A.M.
Santegoets1, H.B.A.C. Stockmann4, P.A.M. van Leeuwen3, S. Meijer3, R.J. Scheper2, R.J.C.L.M. Vuylsteke4, P. van den
Tol3, A.J.M. van den Eertwegh1, T.D. de Gruijl1
Departments of 1Surgical Oncology, 2Medical Oncology, and 3Pathology, VU University Medical Center, Amsterdam, The
Netherlands and 4Department of Surgery, Kennemergasthuis, Haarlem, The Netherlands.
Harry J. Lloyd Charitable Trust, Heelkundefonds
50. Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell cancer
C.M. Huijts1, S.J.A.M. Santegoets1, A.J.M. van den Eertwegh1, L.S. Pijpers1, J.B. Haanen2, T.D. de Gruijl1, H.M.W.
Verheul1, H.J. van der Vliet1
Department of 1Medical Oncology, VU University Medical Center, Amsterdam; 2 Division of Immunology, The
Netherlands Cancer Institute, Amsterdam
Lung cancer
51. Activity of Novel Irreversible Inhibitors of Epidermal Growth Factor Receptor in Non Small Cell Lung Cancer
E. Galvani,a,b C. Carmi,c F. Vacondio,c A. Cavazzoni,a R.R. Alfieri,a E. Giovannetti,b M. Mor,c P.G. Petronini,a G.J.
Peters.b
a University of Parma, Department of Experimental Medicine, Italy;
bVU University Medical Center, Department of Medical Oncology, Amsterdam, The Netherlands;
c University of Parma, Pharmaceutical Department, Italy
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -143
AIRC (Italian Association for Cancer Research)
52. Evaluation of DTS for spine position monitoring and lung tumour position verification
J. van Sörnsen de Koste, M. Dahele, L. van der Weide-Berkelaar, S. Senan, B.J. Slotman, W.F.A.R. Verbakel
Department of Radiation Oncology, VU University Medical Center, Amsterdam
Varian Medical Systems, Palo Alto, USA
53. Stereotactic ablative radiotherapy for early-stage lung cancer
S. Senan, W.F.A.R. Verbakel, F.J. Lagerwaard, D.A. Palma2, C.J. Haasbeek, C.L. Ong, A.V. Louie, D. Rodrigues, N.E.
Verstegen, J.P. Cuijpers, A.V. Louie2, J.T.Annema3, B.J., Slotman
1.Departments of Radiation Oncology, VU University Medical Center, Amsterdam, 2Department of Radiation Oncology,
London Regional Cancer Program, London, Ontario, Canada, and 3Department of Epidemiology and Biostatistics,
Erasmus MC, Rotterdam, Netherlands, 3 Department of Pulmonology, Academic Medical Centre, Amsterdam, The
Netherlands
Canadian Association of Radiation Oncology Elekta Research fellowship; Resident Research Career Development Award
from the University of Western Ontario; Detweiler Travelling Fellowship from the Royal College of Canadian Physicians
and Surgeons of Canada
54. The molecular mechanisms underlying bortezomib sensitization to rhTRAIL differ among individual Non-Small Cell Lung
Cancer Cells
L.H.A.M. de Wilt1*, J.H. Stegehuis2*, M. Klok2,E.G.E de Vries2, G. Jansen3, S. de Jong2, G.J. Peters1, F.A.E. Kruyt2
1Department of Medical Oncology, VU University Medical Center, Amsterdam, the Netherlands, 2Department of Medical
Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands, 3Department of
Rheumatology, VU UniversityMedicalCenter, Amsterdam, the Netherlands
55. The novel thymidylate synthase inhibitorTrifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung
cancer cells
K. Azijli1,2, I. van Roosmalen1, J. Smit2, S. Yuvaraj1, M. Fukushima3,S. de Jong1,I.V. Bijnsdorp2,4, and G.J. Peters2,
F.A.E. Kruyt1*
1. Department of Medical Oncology, University of Groningen, UniversityMedicalCenterGroningen, Groningen, the
Netherlands; 2. Department of Medical Oncology, VU UniversityMedicalCenter, Amsterdam, the Netherlands; 3.
Tokushima Research Center, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan; 4. Department of Urology, VU
UniversityMedicalCenter, Amsterdam, the Netherlands
Oncolytic adenovirus
56. Enhancement of the oncolytic potency of conditionally replicative adenoviruses
W. Dong1, K.Y. Au1, A. Gros2, J.W.G. van Ginkel1, M. Cascallo2, W.R. Gerritsen3, R. Alemany2, J.J.M. Meulenberg1, V.W.
van Beusechem1,3
1ORCA Therapeutics, Amsterdam, The Netherlands; 2Translational Research Laboratory, IDIBELL-Institut Català
d’Oncologia, Barcelona, Spain; and 3Department of Medical Oncology, VU University Medical Center, Amsterdam, The
Netherlands
57. Exploiting miRNA to enhance oncolytic adenovirus potency
V.W. van Beusechem1,2, J. Hodzic1, T. Gupta1, H. Kristyanto1, A. Vermeulen3, J. Karpilow3, J.J.M. Meulenberg2
1Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands; 2ORCA Therapeutics,
Amsterdam, The Netherlands; 3Thermo Fisher Scientific, Dharmacon RNAi Technologies, Lafayette, CO, USA
58. Virotherapy of glioblastoma multiforme using an infectivity-enhanced selectively replication-competent adenovirus
V.W. van Beusechem1, M.L.M. Lamfers2, J.M. Amado de Azevedo1, I.H. van der Meulen-Muileman1, S. Idema3, W.R.
Gerritsen1, W.P. Vandertop3, D.P. Noske3, C.M.F. Dirven2
Departments. of 1Medical Oncology and 3Neurosurgery, VU University Medical Center, Amsterdam; 2Department
Neurosurgery, Erasmus MC, Rotterdam
ZonMw Translationeel Gentherapeutisch Onderzoek 43200003
Pancreatic cancer
59. Crizotinib inhibits metabolic inactivation of gemcitabine in ortothopic pancreatic tumors from primary cells with c-Met
overexpression
A. Avan1*, V. Caretti2,3*, N. Funel4,*, E. Galvani1, M. Maftouh1, R.J. Honeywell1, T. Lagerweij3, O. Van Tellingen5, D.
Campani4, D. Fuchs6, H.M.W. Verheul1, G.J. Schuurhuis7, U. Boggi4, G.J. Peters1, T. Würdinger3,8, E. Giovannetti1,#
1Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands; 2Department of
Neurology & Neurological Sciences, Stanford University Hospital, Stanford, California, US; 3Neuro-oncology Research
Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam,
The Netherlands; 4Department of Surgery, University of Pisa, Pisa, Italy; 5Diagnostic Oncology Division, Netherlands
Cancer Institute, Amsterdam, The Netherlands; 6VisualSonics, Amsterdam, The Netherlands; 7Department of
Hematology, VU University Medical Center, Amsterdam, The Netherlands; 8Molecular Neurogenetics Unit, Department of
Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, Massachusetts,
US
60. CYB5A role in pancreatic cancer prognosis and autophagy modulation
E. Giovannetti1, Q. Wang7, A. Avan1, N. Funel4, E. Galvani1, T. Lagerweij2, D. Chiasserini1, J.-H. Lee7, V. Caretti2,5, A.
van der Velde3, U.Boggi4, Y. Wang7, E. Vasile4, G.J. Peters1, T. Wurdinger2,6, G. Giaccone7
1Dept. Medical Oncology, 2Dept. Neurosurgery, VU University Medical Center, and 3Centre for Integrative Bioinformatics,
VU University, 1081HV, Amsterdam, The Netherlands; 4Dept. RicercaTraslazionale e delleNuoveTecnologie in Medicina e
Chirurgia, University of Pisa, 56100 Pisa, Italy; 5Dept. Neurology, Stanford University, Stanford, CA 94305-5461, US,
6Dept. Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA
02129, US; 7Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 208921906, US
61. Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A (DZNeP) with
gemcitabine in pancreatic cancer cells
A. Avan1,* F. Crea2,* E. Paolicchi2,* N. Funel3, E. Galvani1, V.E. Marquez4, R. Honeywell1, R. Danesi2, G.J. Peters1,# E.
Giovannetti1
1Department of Medical Oncology, VU University Medical Center, Amsterdam, 2Department of Internal Medicine,
University of Pisa, Italy; 3Department of Surgery, University of Pisa, Italy; 4NIH, Frederick, MD, US
CCA Foundation
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -144
62. Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of the novel Akt inhibitor
perifosine with gemcitabine in pancreatic cancer
Mina Maftouh1,*, Amir Avan1,3,* Abolfazl Avan1, Anne van Krieken1, Nicole van Grieken2, RajivRaktoe1, Niccola Funel4,
Sara Caponi5, Ugo Boggi6, Leticia L. Leon7, B. Aicher8, Godefridus J. Peters1,# Elisa Giovannetti1
Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam, De Boelelaan 1117, 1081
HV Amsterdam, The Netherlands, 3Biochemistry of Nutrition Research Center, and Department of New Sciences and
Technology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Departments of 4Pathological
Surgery, 5Oncology, and 6General Surgery and Transplants University of Pisa, via Roma 55, 56100 Pisa, Italy; 7Center for
Biomedical Research of the Canary Islands, Instituto de TecnologiasBiomedicas, University of La Laguna, La Laguna,
Spain, 8Æterna Zentaris GmbH, Weismuellerstrasse 50, 60314 Frankfurt am Main, Germany
63. Phosphoproteomics and the prediction of outcome and treatment of pancreatic cancer
T.Y.S. Le Large, E. Giovannetti, M. Bijlsma, C. Jimenez, H.M.W. Verheul
Department of Medical Oncology, VU University Medical Center Amsterdam
64. The Good, the Bad and the Ugly: a Tale of MiR-101, MiR-21 and MiR-155 in Pancreatic Intraductal Papillary Mucinous
Neoplasms
Giovannetti E1, Caponi S,2 Funel N,3 Frampton AE,4 Santarpia L,6 Van der Velde A,7 L.R. Jiao,4 Falcone A,2 Kazemier G,8
Meijer GA,9 Vasile E,2 Boggi U,5 Verheul HMW,1 Peters GJ1
1Department of Medical Oncology, VU University Medical Center, 2Unit Medical Oncology-2, Pisa, Italy; 3Department of
Surgical Pathology, Pisa University, Pisa, Italy; 4HPB Surgical Unit, Department of Surgery, Imperial College, London, UK;
5Department of Oncology, Division of Surgery, Pisa University Pisa, Italy; 6Department of Oncology, Translational
Research Unit, Hospital of Prato, Prato, Italy; 7Centre for Integrative Bioinformatics, VU University; 8Department of
Surgery, VU University Medical Center; 9Department of Pathology, VU University Medical Center
NWO-Veni grant
65. Unraveling the role of CYB5A in pancreatic ductal adenocarcinoma (PDAC): correlation with clinical outcome and
functional characterization in the modulation of autophagy and oncogenic phenotypes
E. Giovannetti,1,* Q. Wang,5,* A. Avan,1 N. Funel,4 T. Lagerweij,2 J.-H. Lee,5 V. Caretti,2 M. Masini,4 U. Boggi,4 Y.
Wang,5 E. Vasile,4 H.M.W. Verheul,1 T. Wurdinger,2,4 G. Giaccone5, G.J. Peters,1
1Dept. MedicalOncology, and 2Dept. Neuro-Oncology, VU University Medical Center, Amsterdam, The Netherlands;
3Dipartimento di RicercaTraslazionale e delleNuoveTecnologie in Medicina e Chirurgia, University of Pisa, Pisa, Italy;
4Department of Neurology, Massachusetts General HospitalandHarvardMedical School, Boston, MA, USA; 5Medical
OncologyBranch, National Cancer Institute, Bethesda, MD, USA
NWO - Veni grant to Elisa Giovannetti
66. A formula based on cystatin C for individual carboplatin dosing in children
H.N. Blufpand1, G.J.L. Kaspers1, F.C.H. Abbink1, A.J. Wilhelm2, R.J. Honeywell3, G.J. Peters3, B. Stoffel-Wagner5, A.
Bökenkamp4
Department of 1Pediatric Oncology/Hematology, 2Clinical Pharmacology and Pharmacy, 3Medical Oncology, 4Pediatric
Nephrology all VU University Medical Center, Amsterdam, The Netherlands. 5Clinical Chemistry and Clinical
Pharmacology, University of Bonn - Medical Center, Bonn, Germany
VUmc Research on Childhood Cancer - VONK and Fonds NutsOhra
67. A medication diary-book for childhood cancer patients in Kenya
G. Olbara1, F. Njuguna1, P.M. van de Ven2, J. Skiles3 , G.J.L. Kaspers4 , S. Mostert4
1 Department of Pediatrics, Moi Teaching and Referral Hospital, Eldoret, Kenya, 2 Department of Epidemiology and
Biostatistics, VU University Medical Center, Amsterdam, the Netherlands, 3 Department of Hematology-Oncology and
Academic Model Providing Access to Healthcare (AMPATH) program, Indiana University School of Medicine, Indianapolis,
United States of America, 4 Department of Pediatric Oncology-Hematology and Doctor 2 Doctor program, VU University
Medical Center, Amsterdam, the Netherlands
68. Compliance with childhood cancer treatment in Kenya
F. Njuguna1, P.M. van de Ven2, J. Skiles3 ,G.J.L. Kaspers4, S. Mostert4
1 Department of Pediatrics, Moi Teaching and Referral Hospital, Eldoret, Kenya, 2 Department of Epidemiology and
Biostatistics, VU University Medical Center, Amsterdam, the Netherlands, 3 Department of Hematology-Oncology and
Academic Model Providing Access to Healthcare (AMPATH) program, Indiana University School of Medicine, Indianapolis,
United States of America
4 Department of Pediatric Oncology-Hematology and Doctor 2 Doctor program, VU University Medical Center,
Amsterdam, the Netherlands
SIOP International Fellowship
69. Elucidation and interference of resistance to temozolomide in pediatric and adult gliomas
L. Hiddingh1,2,3, D.P. Noske1,3, W.P. Vandertop1, P. Wesseling4,5 G.J.L. Kaspers2, T. Wurdinger1,3,6
Departments of 1Neurosurgery and 2Pediatric oncology / 3Neuro-oncology Research Group, Cancer Center Amsterdam,
Department of 4Pathology, VU University Medical Center Amsterdam, Department of 5Pathology, Radboud University
Nijmegen Medical Center, Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard Medical School,
Boston, MA6
KiKa, Stichting Stophersentumoren.nl
70. In vitro drug response and efflux transporters associated with drug resistance in pediatric high grade glioma and diffuse
intrinsic pontineglioma
S.J. Veringa, D. Biesmans, D.G. van Vuurden M.H. Jansen, L.E. Wedekind, I. Horsman, P. Wesseling, W.P. Vandertop, D.P.
Noske, G.J. Kaspers, E. Hulleman
Departments of Pediatric Oncology/Hematology, Pathology and Neurosurgery, VU University Medical Center, Amsterdam
71. Parents’ and Health-Care Providers’ Perspectives on Side-Effects of Childhood Cancer Treatment in Manado, Indonesia
S. Gunawan1, E.E. Wolters2, J.A.P. van Dongen2, P.M. van de Ven3, M.N. Sitaresmi4, A.J.P. Veerman2, M.F.J. Mantik1,
G.J.L. Kaspers2, S. Mostert2
1Department of Pediatric Oncology-Hematology, Prof Dr RD Kandou Hospital, Manado, Indonesia, 2Department of
Pediatric Oncology-Hematology, VU University Medical Center, Amsterdam, the Netherlands, 3 Epidemiology and
Biostatistics, VU University Medical Center, Amsterdam, the Netherlands, 4 Department of Pediatrics, Dr Sardjito
Hospital, Gadjah Mada University, Yogyakarta, Indonesia
72. The role of epigenetics in the treatment of pediatric brain tumors
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -145
S.E. Mir1, E. Hulleman1,2, D. Biesman1, M. Smits2, S. Pons4, T. Wurdinger2, D. Noske2, G.J.L. Kaspers1, J. Cloos1,3
Departments of 1Pediatric Oncology/ Hematology, 2Neurosurgery, and 3Hematology, VU University Medical Center,
Amsterdam, 4Department of Cell Death and Proliferation, Institute for Biomedical Research of Barcelona
Mozaiek, KWF fellowship
Personalized medicine
73. A randomized multicenter clinical trial for patients with multi-ORgan, Colorectal cancer metastases comparing the
combination of cHEmotherapy and maximal tumor debulking versuS chemoTheRapy Alone: ORCHESTRA.
E. Gootjes, D. Poel, J. Voortman, M. Neerincx, T. Buffart, E.van Meerten, P. van den Tol, J.W.A Burger, M.R. Meijerink, N.
Haasbeek, J.J. Nuyttens, P. van de Ven, C.R. Jimenez, A.J. Ten Tije, L. te Velde, S. Dwarkasing, O.S. Hoekstra, G.A. Meijer,
K. Biermann, D. W. Albeda, C. Verhoef, H.M.W. Verheul
Department of Medical Oncology, Pathology and Radiology & Nuclear Medicine, VU University Medical Center Amsterdam
74. Adaptation of a human gut epithelial model in relation to the assessment of clinical pharmacokinetic parameters for
selected tyrosine kinase inhibitors
R.J. Honeywell, C. Fatmawati, I. Kathman, G.J. Peters
Dept. of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
75. Clinical evaluation of the underlying mechanisms of targeted therapy related toxicities
M. Rovithi1, H. Berkhof2, T.D. de Gruijl1, C.R. Jimenez1, M.Labots1, G.A. Meijer3, G.J. Peters1, S.Santegoets1, A.A. van
Bodegraven4, N.C.T van Grieken3, C. van Montfrans5, A.J.M van den Eertwegh1, H.M.W. Verheul1
Departments of 1Medical Oncology, 2Biostatistics, 3 Pathology, 4 Gastroenterology and 5 Dermatology of the VU
University Medical Center
76. Design and synthesis of Quinazolinone Tagged Acridones as Cytotoxic Agents and their EGFR Tyrosine Kinase Inhibition
Studies
V.V.S. Rajendra Prasad3,4, Y. Rajesh Babu 1, M. Bhagavanraju1, G. Deepak Reddy2, G.J. Peters4
1Department of Pharmaceutical Chemistry, Gland Institute of Pharmaceutical Sciences,
Narsapur, India. 2Medicinal
Chemistry Research Division, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, India. 3Department
of Pharmaceutical Chemistry, Sitha Institute of Pharmaceutical Sciences, Bachupally, Hyderabad, India. 4Department of
Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
77. Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360)
G.J. Peters1, K. Smid1, L. Vecchi1, I. Kathmann1, D. Sarkisjan1, R.J. Honeywell, N. Losekoot1, O. Ohne2, A. Orbach2, E.
Blaugrund2, L. Shin Jeong3, Y. Bok Lee4, C.H. Ahn4, D. Kim4.
1Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands;
2Teva Pharmaceutical Industries Ltd., Innovative Global Branded Products, P.O.BOX 8077, Hatrufa St. , Poleg Industrial
Zone, Netanya 42504, Israel; 3College of Pharmacy, Ewha Woman's University, Seoul, Korea, 4Rexahn Pharmaceuticals,
Inc., Rockville, Maryland, USA
78. Prediction of response to kinase inhibitors based on protein phosphorylation profiles in tumor tissue from advanced
renal cell cancer patients (PRESPECT)
J. van der Mijn, M. Labots, G.J. Peters, A.J.M. van den Eertwegh, T.D. de Gruijl, C.R. Jimenez, T. Pham, S. Piersma, G.A.
Meijer, D.L. van der Peet, M.R. Meijerink, J.Berkhof, H.M.W. Verheul
Department of Medical Oncology, Surgery, Epidemiology and Biostatistics and Pathology, VU University Medical Center
Amsterdam
79. Selection of the best blood compartment to measure cytidine deaminase activity to stratify for optimal gemcitabine or
cytarabine treatment
M. Maulandi1,2, R.J. Honeywell1, E. Giovannetti1, N. Losekoot1, M.C. Etienne-Grimaldi3, G. Milano3, C. Serdjebi2, J.
Ciccolini2, G.J. Peters1, for the EORTC-Pharmacology and Molecular Mechanism Group
1Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. ²
Transfer Oncology Laboratory, Aix-Marseille University, Marseille, France.³ Laboratoired'Oncopharmacologie, Centre
Antoine Lacassagne, Nice, France
80. Stereotactic ablative radiotherapy for lung cancer and comparative effectivess research
S. Senan, D.A. Palma2, W.F.A.R. Verbakel, F.J. Lagerwaard, C.J. Haasbeek, C.L. Ong, A.V. Louie, D. Rodrigues, N.E.
Verstegen, J.P. Cuijpers, A.V. Louie2, B.J. Slotman
Departments of Radiation Oncology, VU University Medical Center, Amsterdam and 2Department of Radiation Oncology,
London Regional Cancer Program, London, Ontario, Canada
81. The STOMACH trial: Surgical Technique: Open versus minimally invasive gastrectomy after chemotherapy
J. Straatman, D.L. van der Peet, M.A. Cuesta
Department of Surgery, VU University Medical Center Amsterdam
82. Towards novel anti-cancer drugs directed against G-protein coupled receptors to improve treatment of prostate, lung and
brain tumors
T. Wurdinger2, R. Leurs3, I de Esch3, V.W. van Beusechem1
Department of 1Medical Oncology, 2 Neurosurgery, VU University Medical Center, Amsterdam and 3Division of Medicinal
Chemistry, faculty of Science VU University Amsterdam
CCA
83. Towards patient tailored cancer treatment supported by molecular imaging IMPACT: Imaging Patients for Cancer drug
selecTion - Metastatic Breast Cancer (IMPACT breast)
E. van Helden, C. Menke, F. Bensch, G.A.P. Hospers, J.A. Gietema, E. Boven, O. Hoekstra, M. Huisman, D. Vugts, G. van
Dongen, H. Hendrikse, C. van Herpen, I. Desar, C.P. Schroder, W.T.A van der Graaf, H.M.W. Verheul, E.G.E de Vries
Department of Medical Oncology and Radiology and Nuclear Medicine, VU University Medical Center Amsterdam
84. USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy
I. García-Santisteban1, G. J. Peters2, E. Giovannetti2 and J. A. Rodríguez1*
1Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU,
Leioa, Spain. 2Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
85. Watchful waiting in patients with good and intermediate risk metastatic renal cell carcinoma; an imaging guided
observational approach
E. van Helden, C.Menke, H.M.W. Verheul, E.G.E. de Vries, I.M.E. Desar, W.T.A van der Graaf
Department of Medical Oncology, VU University Medical Center, Amsterdam
Prostate cancer
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -146
86. A phase I/II trial of Cabazitaxel +/- Rhenium-188 HEDP in patients with metastatic castration resistant prostate cancer
who progressed on or after a docetaxel containing treatment (ReCab)
J. van Dodewaard-de Jong, H. Bloemendal, J. De Klerk, A. van den Eertwegh, A. ten Tije, O. Hoekstra, H.M.W. Verheul et al
Department of Medical Oncology, VU University Medical Center Amsterdam
87. A Randomised, Phase II, Study of Repeated Rhenium-188 HEDP combined with Docetaxel versus Docetaxel alone in
Castration Resistant Prostate Cancer (CRPC) Metastatic to Bone (TAXIUM II)
J. van Dodewaard-de Jong, H. Bloemendal, J.M.H De Klerk, A.J.M van den Eertwegh, J. O'Sullivan, B. van Bezooijen, O.
Hoekstra, H.M.W. Verheul
Department of Medical Oncology, VU University Medical Center, Amsterdam
Radiotherapy
88. Development of advanced planning strategies
J. Tol, M. Dahele, B.J. Slotman, W.F.A.R. Verbakel
Department of Radiation Oncology, VU University Medical Center, Amsterdam
Varian Medical Systems, Palo Alto, USA
89. Diagnosis, cost-effectiveness of local therapies for early-stage non-small celllungcancer
A.V. Louie, FJ.Lagerwaard, D.A. Palma2, G. Rodrigues2, M.G. Hunink3, B.J. Slotman, S. Senan.
Departments of Radiation Oncology, VU University Medical Center, Amsterdam, 2Department of Radiation Oncology,
London Regional Cancer Program, London, Ontario, Canada, and 3Department of Epidemiology and Biostatistics,
Erasmus MC, Rotterdam, Netherlands
CARO-Elekta Research Fellowship (2013), Detweiler Travelling Fellowship of the Royal College of Physicians and Surgeons
of Canada (2014)
90. Distinguishing between local recurrence and fibrotic changes following SABR
S. Senthi, K Huang2, DA Palma2, CJA Haasbeek, AD Ward2, S Mattonen, BJ Slotman, FJ Lagerwaard, M Dahele, S Senan
Departments of Radiation Oncology, VU University Medical Center, Amsterdam, 2Department of Radiation Oncology,
London Regional Cancer Program, London, Ontario, Canada
91. Image-guided radiotherapy (IGRT)
S. Senan, W.F.A.R. Verbakel, M. Dahele, J.R. van Sörnsen de Koste, P. Doornaert, J.P. Cuijpers, F.J. Lagerwaard, C.L. Ong,
C.J. Haasbeek, F.O.B. Spoelstra, B.J. Slotman
Departments of Radiation Oncology, VU University Medical Center, Amsterdam
92. Innovative techniques for intracranial stereotactic radiotherapy
Lagerwaard FJ, Meijer OWM, Haasbeek CJA, Vandertop WP, Baaijen JC, van den Berg R, Postma TJ, Leemans CR, Slotman BJ
Departments. of Radiation Oncology, Neurosurgery, Radiology & Nuclear Medicine, Otolaryngology/Head and Neck
Surgery and Neurology, VU University Medical Center, Amsterdam
Varian - RapidArc
93. Stereotactic ablative ratiotherapy (SABR) for oligometastases
M. Dahele, C.J.A. Haasbeek, W.F.A.R. Verbakel, D.A. Palma2, B.J. Slotman, S. Senan
Departments of Radiation Oncology, VU University Medical Center, Amsterdam, 2 1Department of Radiation Oncology,
London Regional Cancer Program, London, Ontario, Canada
94. Study on the interaction between angiogenesis inhibition and radiotherapy
E.A. Kleibeuker1, K. Castricum1, A.W. Griffioen2, H.M.W. Verheul2, B. Slotman1, S. Senan1, V.L.J.L. Thijssen1,2
Departments. of 1Radiation Oncology, VU University Medical Center, and 2Medical Oncology, VU University Medical
Center (Stichting VUmc Cancer Center Amsterdam
Stichting VUmc Cancer Center Amsterdam CCA2011-1-03
Resistance to therapy
95. Identification of genes involved in resistance of lung cancer cells to cisplatin
E. Siebring-van Olst1, R.X. de Menezes2, E.F. Smit1, V.W. van Beusechem3
Departments. of 1Pulmonary Diseases, 2Epidemiology and Biostatistics, and 3Medical Oncology, VU University Medical
Center, Amsterdam
Stichting CCA / Walter Bruckerhoff Stiftung
96. Identification of genes involved in resistance of prostate cancer cells to irradiation
J. Hodzic1, B. van Triest2, A. Geldof3, R.X. de Menezes4, W.R. Gerritsen1, M. Verheij2, V.W. van Beusechem1,5
Departments of 1Medical Oncology, 3Urology, 4Epidemiology and Biostatistics and 5RNA Interference Functional
Oncogenomics Laboratory, VU University Medical Center, Amsterdam; 2Department of Radiotherapy, The Netherlands
Cancer Institute, Amsterdam
Stichting CCA
97. NF-κB drives acquired resistance to a novel T790M-mutant selective EGFR inhibitor
E. Galvani1, J. Sun2, L.G. Leon3, R. TjinTham Sjin4,H.J. Haringsma5,A. van der Velde6, D.A.M. Heideman7, A.D.
Simmons5, T.C. Hardings5, P. Giorgio Petronini8, R. Bernards9, E.F. Smit10, W. Pao2, G.J. Peters1, E. Giovannetti1,*
1Department Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The
Netherlands, 2Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, US, 3Instituto de TecnologiasBiomedicas, Center
for Biomedical Research of the Canary Islands, University of La Laguna, Spain, 4CelgeneAvilomics Research, Bedford, MA
01730, US, 5Clovis Oncology Inc., San Francisco, CA 94158, US, 6Boston University, Boston, MA, US, 7Department of
Pathology, VU University Medical Center, Amsterdam, The Netherlands, 8Department of Clinical and Experimental
Medicine, University of Parma, Parma, Italy, 9Division of Molecular Carcinogenesis,The Netherlands Cancer Institute,
Amsterdam, The Netherlands, 10Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The
Netherlands
98. Phase II study of sunitinib rechallenge in patients with metastatic renal cell carcinoma (SURE)
M. Labots, C. Huijts, K.J. Gotink, T. de Gruijl, G.J Peters, C.R. Jimenez, A.J.M. van den Eertwegh, J.J. van der Vliet, H.M.W.
Verheul
Department of Medical Oncology, VU University Medical Center Amsterdam
99. Resistance to receptor tyrosine kinase inhibitors
H.J. Broxterman, K.J. Gotink, M. Labots, R.R. de Haas, H. Dekker, V. van Beusechem, R.J. Honeywell, G.J. Peters, H.M.W.
Verheul
Department of Medical Oncology, VU University Medical Center
100. Targeted therapy of osteosarcoma
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -147
J. Posthuma de Boer1, M. N. Helder1, V.W. van Beusechem2, G.J.L. Kaspers3,B.J. van Royen1
1 Department of Orthopaedic Surgery, VU University Medical Center, 2 Department of Medical Oncology, VU University
Medical Center and 3 Department of Pediatric Oncology/Haematology, VU University Medical Center
The Strategic Regeneration Network, Aarhus University Hospital, Denmark; VONK and the department of Orthopaedic
Surgery, VU University Medical Center, Amsterdam
101. Targeting resistance to radio-chemotherapy by inhibition of the PI3Kinase-Akt signaling pathway
R.S. Narayan1, L.J.A. Stalpers2, B. G. Baumert3,6, M.E. van Linde4, N.A.P. Franken2, J. van den Berg1, J. Theys3, B.J.
Slotman1, T. Wurdinger5, P. Sminia1
Departments. 1Radiation Oncology, 4Medical Oncology,5Neuro-Oncology Research Group, VU University Medical Center;
Department 2Radiation Oncology, Academic Medical Center, Amsterdam; 3Department Radiation Oncology Maastricht
Universitair Medisch Centrum; 6Mediclin Robert-Janker-Clinic & University of Bonn Medical Centre, Cooperation Unit
Neurooncology, Bonn, Germany
KWF 2010-4874
Rheumatoid diseases
102. Assessment of disease activity of ankylosing spondylitis with [18F]Fluoride PET-CT
S.T. Bruijnen1, M. John1, I.E. van der Horst1, J. Bot2, C. van Kuijk2, O.S. Hoekstra2, D. Baeten3, C.J. van der Laken1
Depts of 1Rheumatology, 2Radiology and Nuclear Medicine, VU University Medical Center, 3Dept of Rheumatology &
Immunology3, Academic Medical Center, Amsterdam
Reumafonds
103. Imaging and targeting of macrophage folate receptor-beta in rheumatoid arthritis
Chandrupatla, Durga1, K. Weijers1, Y.Y.J. Gent1, G. Jansen1, C.F.M. Molthoff2, A.D. Windhorst2, J.W. van der Heijden1, A.
Voskuyl1, P.S. Low3, M. Ratnam4, Y.G. Assaraf 5, A.A. Lammertsma2, B.A.C. Dijkmans1, and C.J van der Laken1
Departments. of 1Rheumatology and 2PET-Center/Nuclear Medicine, VU University Medical Center, Amsterdam, The
Netherlands, 3Endocyte, West Lafayette, IN, USA, 4Department of Biochemistry and Molecular Biology, Medical University
of Toledo, Toledo, OH. U.S.A., 5Department of Biology, The Technion, Israel Institute of Technology, Haifa, Israel
Nationaal Reumafonds NRF-09-404
104. Resistance to proteasome inhibitors in cancer and reumatoid arthritis
B. Dijkmans1, T.D. de Gruijl2, R.J. Scheper3, G. Jansen1
1Department Of Reumatology, 2Medical Oncology and 3Pathology, VU University Medical Center, Amsterdam
VUmc Cancer Center Amsterdam
Other
105. Absorptiometry in ICU patients
R.J.M. Strack van Schijndel1, N.J. Wierdsma2, A.A. van Bodegraven3
1Department of Intensive Care, 2Department of Nutrition and Dietetics and 3Department of Gastroenterology, Small
Bowel Disease Unit VU University medical centre, Amsterdam
106. Oxaliplatin, bortezomib and epothilone-B induced neurotoxicity: characterization and protection
Abolfazl Avan2,3,*, Cecilia Ceresa1,*, Elisa Giovannetti3, Albert A. Geldof4, Amir Avan3, Guido Cavaletti1, Godefridus J
Peters3
1Department of Surgery and Interdisciplinary Medicine, University of Milano-Bicocca, Monza, Italy; 2Department of
Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 3Department of Medical
Oncology, and 4Department of Urology, VU University Medical Center, Amsterdam, The Netherlands
Program 5
Child
1. Accelerated aging, decreased white matter integrity, and associated neuropsychological dysfunction 25 years after
pediatric lymphoid malignancies
I. Schuitema1,2, S. Deprez, W. Van Hecke, M. Daams, A. Uyttebroeck, S. Sunaert, F. Barkhof, E. van Dulmen-den Broeder,
H.J. van der Pal, C. van den Bos3, A.J. Veerman1, L.M. de Sonneville2
1Pediatrics Oncology/Hematology, VU University Medical Center, Amsterdam; 2Department of Child and Adolescent
Studies, University of Leiden, Leiden; 3Department of Pediatrics, Division of Pediatric Hematology and Oncology,
Amsterdam Medical Center, Amsterdam
2. Carboplatin dosing in children using estimated glomerular filtration rate: equation matters
H.N. Blufpand1, G.J.L. Kaspers1, F.C.H. Abbink1, A.J. Wilhelm2, R.J. Honeywell3, G.J. Peters3, B. Stoffel-Wagner5, L.M.
Buffart6, A. Bökenkamp4
Department of 1Pediatric Oncology/Hematology, 2Clinical Pharmacology and Pharmacy, 3Medical Oncology, 4Pediatric
Nephrology and 5EMGO Institute for Health and Care Research and the department of Epidemiology and Biostatistics, VU
University Medical Center, Amsterdam, The Netherlands. 6Clinical Chemistry and Clinical Pharmacology, University of
Bonn - Medical Center, Bonn, Germany
VUmc Research on Childhood Cancer - VONK and Fonds NutsOhra
3. Clinical trials to improve childhood cancer care and survival in sub-Saharan Africa
T. Israëls, J. Kambugu, F. Kouya, N.K. El-Mallawany, P.B. Hesseling, G.J. Kaspers T. Eden, L. Renner, E.M. Molyneux
Department of Pediatric Oncology-Hematology, VU University Medical Center, Amsterdam, the Netherlands, 3
Department of Pediatrics, Dr Sardjito Hospital, GadjahMada University, Yogyakarta, Indonesia, 4 Department of Pediatric
Oncology-Hematology, VU University Medical Center, Amsterdam, the Netherlands
4. Compliance with childhood cancer treatment in Yogyakarta, Indonesia
D. Susilawati1, M.N. Sitaresmi2, S. Mostert3, E. Supriyadi4, I.L. Gamayanti1, P.H. Widjajanto4, G.J.L. Kaspers3
1 Psychology, Dr Sardjito Hospital, Yogyakarta, Indonesia, 2 Social Pediatrics, Dr Sardjito Hospital, Yogyakarta, Indonesia,
3Oncology-Hematology, VU University Medical Center, Amsterdam, the Netherlands, 4 Oncology-Hematology, Dr Sardjito
Hospital, Yogyakarta, Indonesia
5. Fertility Impairment in female childhood cancer survivors. Workpackage 3 in PanCareLIFE: PanCare studies in fertility and
ototoxicity to improve quality of life after cancer during childhood, adolescence and young adulthood
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -148
M. van Dijk1, M.H. van den Berg1, C.B. Lambalk2, MA Veening1, L.C.M. Kremer3, M.M. van den Heuvel-Eibrink4, F.E. van
Leeuwen5 G.J.L. Kaspers1, E. van Dulmen-den Broeder1 on behalf of the DCOG LATER Study Group
Departments. of 1Pediatric Oncology/Hematology and 2Obstetrics & Gynaecology, VU University Medical Center, 3Emma
Children’s Hospital AMC Amsterdam, 4ErasmusMC/Sophia Childrens Hospital, Rotterdam, 5 Epidemiology ,Netherlands
Cancer Institute, Amsterdam
EU FP7 Health 2013 (602030)
6. Late effects of illness and treatment and quality of life in pediatric oncology patients
E. van Dulmen-den Broeder1, M.H. van den Berg1, M.A. Veening1, Kooter AJ2, G.J.L. Kaspers1
1Pediatric Oncology/Hematology, 2Internal Medicine, VU University Medical Center, Amsterdam
VONK
7. Optimizing survivor participation rate in late effects studies. An evaluation of response rates, questionnaire mode
preferences and satisfaction of Dutch childhood cancer survivors invited for the DCOG LATER study (the DCOG LATERMIK EPI study)
E. Kilsdonk2, M.H. van den Berg1, M. Jaspers2, FE. Van Leeuwen3, E.van Dulmen-den Broeder1 on behalf of the DCOGLATER Study Group
2Emma Children’s Hospital AMC Amsterdam, 1VU University Medical Center, Amsterdam, 3Netherlands Cancer Institute,
Amsterdam
SKION LATER/ KiKa
8. Reproductive function, ovarian reserve, and risk of premature menopause in female childhood cancer survivors: a
nationwide study
A. Overbeek1, M.H. van den Berg1, C.B. Lambalk2, G.J.L. Kaspers1, F.E. van Leeuwen3, E. van Dulmen-den Broeder1
Departments. of 1Pediatric Oncology/Hematology and 2Obstetrics & Gynaecology, VU University Medical Center,
3Epidemiology, Netherlands Cancer Institute, Amsterdam
KWF / Kika Foundation 2006-3622
9. SLAAP studie: Sleep in children with Acute leukemia and Additional cost to the parents: a study into the effect on quality
of life
R.R.L. van Litsenburg1, M.S. Gordijn2, M.A. Grootenhuis3, G.J.L. Kaspers1
Department of 1 Pediatric Oncology-hematology, VU University Medical Center Amsterdam, 2 Pediatrics, VU University
Medical Center Amsterdam, 3 Psychosocial department, Emma Children’s Hospital AMC Amsterdam
10. Sleep, fatigue and quality of life in survivors of childhood acute lymphoblastic leukemia
M.S. Gordijn1, R.R.L. van Litsenburg1, RJ.B.J. Gemke1, J. Huisman2, M.B. Bierings3, P.M. Hoogerbrugge5, G.J.L. Kaspers1
Departments. of 1Pediatrics and Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, 2 Medical
Psychology, VU University Medical Center, Amsterdam / Pediatric Psychology & Social Work, University Medical Center
Utrecht, 3Pediatric Hematology/Oncology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, 4Pediatric
Hemato-Oncology, Radboud University Nijmegen Medical Center
KWF VU 2010-4859
11. Structured home-visit and follow-up program for childhood cancer patients in Yogyakarta, Indonesia
S. Gunawan,MD2, PM van de Ven,MSc,PhD3 , MN Sitaresmi,MD,PhD4 , M Mantik,MD2, GJL Kaspers,MD,PhD1 ,S
Mostert,MD,PhD1
1 Department of Pediatric Oncology-Hematology, Prof Dr RD Kandou Hospital, Manado, Indonesia, 2 Epidemiology and
Biostatistics, VU University Medical Center, Amsterdam, the Netherlands, 3 Department of Pediatrics, Dr Sardjito
Hospital, GadjahMada University, Yogyakarta, Indonesia, 4 Department of Pediatric Oncology-Hematology, VU University
Medical Center, Amsterdam, the Netherlands
SMALL Foundation
Exercise
12. A combined physical exercise and psychosocial training program to improve physical fitness in children with cancer
K.I. Braam1, E.M. van Dijk2, E. van Dulmen-den Broeder1, M.A. Veening1, M. Bierings3, J. van der Net3, J.H.M. Merks4,
M.A. Grootenhuis4 G. Sinnema3, M. Chinapaw5, M.M. van den Heuvel-Eibrink6, I. Streng6, T. Takken3, J. Huisman2, G.J.L.
Kaspers1
1Pediatric Oncology/ Hematology, VU University Medical Center, and 2Department of medical Psychology VU university
medical center; 3Wilhelmina Children’s Hospital, University Medical Center Utrecht; 4Academic Medical Centre,
Amsterdam; 5EMGO institute, VU University Medical Center, 6Erasmus MC/Sophia Childrens Hospital, Rotterdam
Alpe d’HuZes/KWF 2009-4305
13. Development of a new questionnaire to measure instrumental activities of daily living (IADL) in patients with primary
brain tumors
L. Dirven1, S.A.M. Sikkes2, J.C. Reijneveld1,3, N.K. Aaronson4, B.M.J. Uitdehaag1, M.J.B. Taphoorn1,5
1 Department of Neurology VU University Medical Center, 2 Department of Epidemiology and Biostatistics, 3 Department
of Neurology, Amsterdam Medical Center, 4 Division of Psychosocial Research and Epidimiology, Netherlands Cancer
Institute, 5 Department of Neurology, Medical Center Haaglanden
DEVON
14. Exercising in head and neck cancer. Netherlands Quality of Life and Biomedical Cohort Studies in Head and Neck Cancer
(NET-QUBIC_HNC)
A van Nieuwenhuizen1, C.R. Leemans1, L. Buffart2,I.M. Verdonck-de Leeuw1
Department of 1Otolaryngology - Head and Neck Surgery, 2Epidemiology and Biostatistics, VU University Medical Center,
Amsterdam
KWF, Alpe- d'Huzes
15. How does exercise reduce fatique in patients with cancer? A pilotstudy examining the role of the muscle (METRIC)
L.M. Buffart, E.Geleijn, R.Huijsmans, H.M.W. Verheul, T.E. Buffart, A.M. May, T.M. Altenburg, C.J. de Ruiter, B.M.J.
Uitdehaag
Departments of Epidemiology & Biostatistics and Medical Oncology, VU University Medical Center Amsterdam
Gastrointestinal and nutritional quality of life aspects
16. Clinical evaluation of the efficacy of methylnaltrexone in resolving constipation induced by different opioid subtypes
combined with laboratory analysis of immunomodulatory and antiangiogenic effects of methylnaltrexone (RILAX)
E.C.W. Neefjes1, J.J. van der Vliet1, M.J.D.L. van der Vorst1, W.W.A. Zuurmond2, H.M.W. Verheul1
Departments. of 1Medical Oncology and 2Anesthesiology of the VU University Medical Center
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -149
Fonds NutsOhra 1201-038
17. Metoclopramide, Dexamethasone or Aloxi for the prevention of delayed chemotherapy-induced nausea and vomiting in
moderately emetogenic non-AC-based chemotherapy (MEDEA)
M.J.D.L. van der Vorst1, J. Dekker2, J. Berkhof3, H.M.W. Verheul1
Departments. of 1Medical Oncology, 2 Psychiatry/Rehabilitation Medicine, 3Epidemiology and Biostatistics, VU University
Medical Center
18. Prevalence and biomarkers of pre-cachexia and cachexia in advanced cancer patients scheduled for treatment with
chemotherapy
S. Blauwhoff-Buskermolen, D.L. van der Peet, J.A.E. Langius, E.F. Smit, M.J.D.L van der Vorst, L.C.W. Neefjes, C.R. Jimenez,
M.E. von Blomberg, H.J. Bontkes, M. Diamant, P.A.M. van Leeuwen, H.M.W. Verheul, M. A.E van Bokhorst- de van der
Schueren
Departments of Nutrition and Dietetics, Surgery, Pathology, Pulmonology and Medical Oncology, VU University Medical
Center Amsterdam
VUMC: VU University Medical Center
Nuts Ohra Zorgsubsidies
19. The effect of individualized NUTritional counselling on muscle mass and treatment outcome in patients with metastatic
COLOrectal cancer undergoing chemotherapy (COLONUT)
A. van der Werf, M.J.D.L van der Vorst, K.S. Versteeg, L.C.W. Neefjes, S. Blauwhogg-Buskermolen, J.Berkhof, H.M.W.
Verheul, J.A.E Langius, M.A.E de van der Schueren.
Department of Nutricion and dietics, Epidemiology & Biostatistics and Medical Oncology, VU University Medical Center
Amsterdam
Patient reported outcome
20. Complications, functional, and cosmetic results in patients treated for retinoblastoma in the Netherlands
D.L. Mourits, D.T. Hartong, M. Bosscha, J.S. Remmers, F. Bak, H.S. Tan, A.C. Moll
Department of Ophthalmology, VU University Medical Center
ODAS
21. Health related quality of life in head and neck cancer patients: survival, response shift, and care
I.M. Oskam1, I.M. Verdonck-de Leeuw1, R. de Bree1, P. Doornaert2, B. Witte3, J.A. Langendijk4, N.K. Aaronson5, C.R.
Leemans1
Deparments 1. Otolaryngology, Head and Neck Surgery, VUmc, 2. Radiotherapy, VUmc, 3. Epidemiology & Biostatistics,
VU University Medical Center Amsterdam, 4. Radiotherapy, UMCG, 4. Division of Psychosocial Research and
Epidemiology, The Netherlands Cancer Institute
VUmc, Otolaryngology, Head and Neck Surgery
22. OncoKompas 2.0: Development and pilot testing of an e-health self-management platform to optimise supportive care in
cancer patients
C.F. van Uden-Kraan1,2, S. Lubberding1, H. Melissant2, C.R. Leemans1, P. Cuijpers2, I.M. Verdonck-de Leeuw1,2
1. Otolaryngology, Head and Neck Surgery, VUmc, 2. Clinical Psychology, VU University
Dutch Cancer Society (KWF), Pink Ribbon, SAG Foundation, NDDO Foundation
23. OncoQuest: touch screen computer based screening of health related quality of life and distress
I.M. Verdonck-de Leeuw1, R. de Bree1, A. Houffelaar1, C.F. van Uden-Kraan1, P. Doornaert2, C.R. Leemans1
1. Otolaryngology, Head and Neck Surgery, VUmc, 2. Radiotherapy, VU University Medical Center, Amsterdam
Fonds NutsOhra, Dept Otolaryngology, Head and Neck Surgery
24. Participation in decision-making to improve quality of life of cancer patients and their proxies: implementation of
advance care planning
L. Dirven1, H.R.W. Pasman2, J.C. Reijneveld1,4, B. Philippsen-Onwuteaka2, O. Visser3, M.J.B. Taphoorn1,5
Departments of 1Neurology, 2EMGO+, 3 Hematology, VU University Medical Center, Amsterdam, 4Department of
Neurology, Academic Medical Centre, Amsterdam,5Department of Neurology, Medical Centre ‘Haaglanden’, Den Haag
DEVON
25. Patient Reported Outcomes in the CAstration-resistant Prostate cancer RegIstry: PRO-CAPRI
H.M. Westgeest, C.A. Uyl-de Groot, A.J.M van den Eertwegh, H.M.W. Verheul, C.H. Smorenburg, M.P. Hendriks, H.P. van
den Berg, M.Geenen, W.R. Gerritsen
Department of Medical Oncology and Epidemiology & Biostatistics, VU University Medical Center Amsterdam
26. Patient reported speech and swallowing outcome in head and neck cancer
R.N.P.M. Rinkel1, I.M. Verdonck-de Leeuw1, N.K Aaronson2, C.R. Leemans1
1. Otolaryngology, Head and Neck Surgery, Vumc, 2. Psychosocial research, The Netherlands Cancer Institute
VUmc, Otolaryngology, Head and Neck Surgery
27. Shared decision making in early-stage lung cancer
W. Hopmans, D.R.M. Timmermans, O.C. Damman, L. Zwaan, C.J.A. Haasbeek, K. Hartemink, E.F. Smit, B.J. Slotman, S.
Senan
Departments. of Radiation Oncology, Public and Occupational Health and the EMGO+ Institute for Health and Care
Research, Surgical Oncology, Pulmonology, VU University Medical Center
Psychosocial aspects
28. Cost effectiveness of psychological intervention via the internet in head and neck cancer patients
A.M.H. Krebber1, F. Smit2, P. Cuijpers2, A. van Straten2, C.F. van Uden-Kraan1,2, A.T.F. Beekman3, C.R. Leemans1, I.M.
Verdonck-de Leeuw1,2
1. Otolaryngology, Head and Neck Surgery, VUmc, 2. Clinical Psychology, VU University, Faculty of Psychology and
Education, 3. Psychiatry, VUmc
Fonds NutsOhra and ZonMW 80-82305-98-09001
29. Distress and quality of life of patients treated with autologous stem cell transplantation following high-dose
chemotherapy: Outcome of stepped care
A. Braamse1, B. van Meijel2, O. Visser3, P.C. Huijgens3, A. Boenink1, P. Cuijpers4, P. van Oppen1 , A.T.F. Beekman1, J.
Dekker1
1 Department of Psychiatry VU University Medical Center, 2 Research Group Mental Health Nursing, Inholland University,
3 Department of Hematology VU University
VU University Medical Center and Inholland University
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -150
30. Early recognition and optimal treatment of delirium in patients with advanced cancer
E. Neefjes, M.J.D.L van der Vorst, H. A. Beeker, A.T.F Beekman, J.Berkhof, W.W.A Zuurmond, H.M.W. Verheul
Departments. of 1Medical Oncology, 2Psychiatry and 3Biostatistics of the VU University Medical Center
ZonMw 1151.0011
31. Help-seeking behavior after autologous stem cell transplantation
A.M.J. Braamse1, O.Visser2, B. van Meijel3, P.C. Huijgens2, A.T.F. Beekman1, J.Dekker1,4
Departments of 1Psychiatry, 2 Hematology, 4 Rehabilitation Medicine, VU University Medical Center, 3 Inholland
University of Applied Sciences, Amsterdam
VU University Medical Center and Inholland University of Applied Sciences
32. Internet-based treatment of low-grade glioma patients with depression and fatigue; randomized controlled trial
F. Boele1, M. Klein1, J.C. Reijneveld2,3, I. Verdonck4,5, J.J. Heimans2, P. Cuijpers5,
Departments of 1Medical Psychology, 2Neurology, VU University Medical Center, 3Neurology, Academic Medical Center,
4Head-Neck Surgery, VU University Medical Center, 5Clinical Psychology, VU University, Amsterdam
KWF (Alpe d'Huzes) 4615-4804
33. Screening and treatment of psychological distress in colorectal cancer with metastasized disease (TES)
C. Schuurhuizen, C. Smorenburg, A. Beeker, C.J van Groeningen, R. Rietbroek, J. Brakenhoff, S.M. van den Heiligenberg, I.
Oving, A. van Bochove, H.J. Bloemendal, M. Los, H.P. van den Berg, A.N.M. Wymenga, J. Douma, C.Tromp, V. Lustig,
E.Batman, J. Dekker, H.M.W. Verheul.
Department of Medical Oncology, Otolaryngology/Head and Neck Surgery and Medical Psychology, VU University Medical
Center Amsterdam
Alpe d’Huzes en KWF Kankerbestrijding
34. Stepped care to improve symptoms of anxiety and depression in cancer patients
A.M.H. Krebber1, F. Smit2, P. Cuijpers2, A. van Straten2, A.T.F. Beekman3, A. Becker4, EF Smit4, C.R. Leemans1, I.M.
Verdonck-de Leeuw1,2
1. Otolaryngology, Head and Neck Surgery, VUmc, 2. Clinical Psychology, VU University, Faculty of Psychology and
Education, 3. Psychiatry, VUmc, 4. Pulmonary Disease, VUmc
ZonMW 600-82600-98-8043/300
35. Structured life review using autobiographical retrieval practice in depressed palliative head and neck cancer patients
G. Kleijn1, R. de Bree2, C.R. Leemans2, A.Becker3, E.F. Smit3, C. Eeltink4, D. Rietveld5, P. Doornaert5, M. van der Vorst6,
M. van den Brekel7, B. Steunenberg8, E.T. Bohlmeijer9, V. Willemsen10, P. Cuijpers1, I.M. Verdonck-de Leeuw1,2
1. Clinical Psychology, VU University, 2. Otolaryngology, Head and Neck Surgery, VUmc, 3. Pulmonary Disease, VUmc, 4.
Hematology, VUmc, 5. Radiotherapy, VUmc, 6. Medical Oncology, VUmc, 7. Otolaryngology, Head and Neck Surgery,
Netherlands Cancer Institute, 8. Julius Center, UMCU, 9. Mental Health, University Twente, 10. Ingeborg Douwes Center,
Amsterdam
ZonMw PZ 1151.0003
36. The development, implementation and evaluation of the meaning-centered group psychotherapy 'Living Meaningfully
with Cancer' in the Netherlands
N. van der Spek1, K. Holtmaat1, C.F. van Uden-Kraan1, R. Tollenaar2, P. Cuijpers1, B Breitbart3, I.M. Verdonck-de
Leeuw1,4
1. Clinical Psychology, VU University, 2. Surgery, LUMC, 3. Psychiatry, Memorial Sloan Kettering Cancer Center, New York,
4. Dept Otolaryngology, Head and Neck Surgery, VU University Medical Center
Duch Cancer Society / Alpe d’HuZes Foundation
Voice, speech, and swallowing in head and neck cancer
37. Efficacy of voice therapy in patients with voice problems after treatment for early glottic cancer
C.D.L. van Gogh1, I.M. Verdonck-de Leeuw1, R.N. Rinkel1, J.A. Langendijk2, P. Doornaert3, H.F. Mahieu1
1Department Otolaryngology/Head-Neck Surgery, VU University Medical Center, 2Department Radiotherapy, University
Medical Center Groningen, 3Department Radiotherapy, VU University Medical Center, Amsterdam
KWF Dutch Cancer Society RUG2008-3983, Fonds NutsOhra 080T-043, Eureka 2614 GGN371, VAZ/CVZ Doelmatigheid
00143 00143
38. LARINX: a web-based self-help programme for laryngectomized patients during and after treatment
I.C. Cnossen1, C.F. van Uden-Kraan1, S.E. Eerenstein1, R. de Bree1, Leemans1, Verdonck-de Leeuw1
1. Otolaryngology, Head and Neck Surgery, VUmc.
Michel Keijzer Fonds / the Netherlands Society of Laryngectomees
39. Objective speech assessment in head and neck cancer: acoustic-phonetic and feature analyses by a neural network
M.J. de Bruijn1, L.F.M. ten Bosch2, J.A. Langendijk3, C.R. Leemans1, I.M. Verdonck-de Leeuw1
1. Otolaryngology, Head and Neck Surgery, VUmc; 2. Centre for Language and Speech Technology, Linguistics, Radboud
University Nijmegen; 3. Radiotherapy, University Medical Center Groningen
VU University Medical Center and Dutch Cancer Society 2008-3983
40. Prevention of speech, swallowing, and shoulder impairment after treatment for head and neck cancer
I.C. Cnossen1, I.M. Verdonck-de Leeuw1, R. de Bree1, R.N.P.M. Rinkel1, Y.J. Aalders1, C.J.T. de Goede2, P. Doornaert3,
D.H.F. Rietveld3, J. Buter4, J.A. Langendijk5, C.R. Leemans1
1. Otolaryngology, Head and Neck Surgery, VUmc; 2. Rehabilitation Medicine, VUmc; 3. Radiotherapy, VUmc; 4. Medical
Oncology, VUmc; 5. Radiotherapy, University Medical Center Groningen
Fonds NutsOhra and Dutch Cancer Society (KWF Kankerbestrijding) 080T-043
Other
41. Castration-resistant Prostate cancer RegIstry (CAPRI): an observational study in the Netherlands
H. Westgeest, WR. Gerritsen, C.A. Uyl-de Groot , R. de Wit, J van Moorselaar, H.M.W. Verheul
Department of Medical Oncology, Epidemiology & Biostatistics and Urology, VU University Medical Center Amsterdam
42. Cost evaluation of supportive care in head and neck cancer. Netherlands Quality of Life and Biomedical Cohort Studies in
Head and Neck Cancer (NET-QUBIC_HNC)
F. Jansen1, C.R. Leemans1, C. Coupé2, I.M. Verdonck-de Leeuw1
Department of 1Otolaryngology - Head and Neck Surgery 2Epidemiology and Biostatistics, VU University Medical Center,
Amsterdam
KWF, Alpe- d'Huzes
43. De patient centraal bij de behandelkeuze voor prostaatkanker
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -151
44.
45.
46.
47.
48.
H. Al-Itejawi, A.N. Vis, C.F. van Uden, I.M. Verdonck-de Leeuw
Department of Urology and Otolaryngology/Head& Neck Surgery, VU University Medical Center, Amsterdam
Health-related quality of life in high-grade glioma patients and their partners in the end-of-life phase
E.M. Sizoo1, J.J. Heimans1, M. Klein2, T.J. Postma1, L. Dirven1, J.A.F. Koekkoek1, R. Grant6, W. Grisold7, C. Marosi 8,G.
Stockhammer9, H.R.W. Pasman3, L. Deliens3 J.C. Reijneveld1,4, M.J.B. Taphoorn1,5
Departments of 1Neurology, 2Medical Psychology, and 3EMGO+, VU University Medical Center, Amsterdam, 4Department
of Neurology, Academic Medical Centre, Amsterdam, 5Department of Neurology, Medical Centre ‘Haaglanden’, Den
Haag, 6Department of Neurology, Western General Hospital, University of Edinburgh, United Kingdom, 7Ludwig Bolzman
Institute for Neuro-Oncology, Kaiser Franz Josef Hospital, Vienna, 8Department of Internal Medicine, Medical Univeristy,
Vienna, and 9Department of Neurology, Neuro-Oncology Group, Medical University of Innsbruck, Austria
Grant: Jacobus Stichting
DEVON
Netherlands Quality of Life and Biomedical Cohort Studies in Head and Neck Cancer (NET-QUBIC)
I.M. Verdonck-de Leeuw1,2, A.J. van Nieuwenhuizen1, L. Korsten1, R.H. Brakenhoff1, J. Smit2, L.M. Buffart3, S. Kleiterp1,
R. de Bree1, J.A. Langendijk4, R. Takes5, Chr. Terhaard6, C.R. Leemans1
1. Otolaryngology, Head and Neck Surgery, VUmc, 2. Clinical Psychology, VU, 3. Epidemiology and Biostatistics, VUmc, 4.
Radiotherapy, UMCG, 5. Otolaryngology, Head and Neck Surgery, UMC Radboud, 6. Radiotherapy, UMCU
Dutch Cancer Society / Alpe d’HuZes Foundation
Optimalization of systemic treatment strategies in elderly patients with advanced solid malignancies
K.S.Versteeg, I.R.H.M. Konings, A.B. Maier, A.A. van de Loosdrecht,G.J. Peters, H.M.W. Verheul
Department Of Medical Oncology and Hematology, VU University Medical Center, Amsterdam
Quality of life in patients treated with radiotherapy for head and neck cancers
P. Doornaert, M.R. Vergeer, C.R. Leemans, B.J. Slotman
Department of Radiation Oncology, Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam
Seizures in glioma patients
J.A.F. Koekkoek1, L. Dirven1, J.J. Heimans1, T.J. Postma1, M. Vos2, J.C. Reijneveld1,3, M.J.B. Taphoorn1,2
1 Department of Neurology, VU University Medical Center, 2 Department of Neurology, Medical Center Haaglanden,3
Department of Neurology, Amsterdam Medical Center
Jacobus Stichting, ZOLEON, Chanrone
Appendix Annual Report 2013 VUmc CCA – Ongoing projects -152
Appendix 8. International collaboration
Type of collaboration*
1: Research
2: Multicenter studies
3: Research network
4: Expert/consult/advisor
Academic
Associate
Collaborating institute
External collaborator(s)
Ang, CW
Emory University, Atlanta, USA
PF Teunis
3
Appelmelk, BJ
School of Biosciences, Birmingham, UK
GS Besra
1
IPBS, Toulouse, France
G Puzo
1
IBMC, Porto, Portugal
R Appelberg
3
Section for Stem Cell Transplantation
and Immunotherapy, ChristianAlbrechts-University and University
Hospital Schleswig-Holstein, Kiel,
Germany
T Valerius
1
Université de Limoges, Limoges, France
M.Cogne
1
Molecular Cellbiology and Immunology,
Amsterdam
M.Van Egmond
1
Haematology, Amsterdam
A. van de Loosdrecht
1
SANQUIN, Amsterdam
G.Vidarsson
1
University of Erlangen, Erlangen,
Germany
F.Nimmerjahn
4
Department of Dermatology. University
Medical Centre, Freiburg, Germany
C.Sitaru
1
Beelen RHJ
Consortium EuTRiPD, 10 full and 3
associate partners, All over europe
See Marie Curie ITN 287813
3
Beliën, JAM
CTMM-TraIT, federated organisation
Public private partnership: all
UMCs, NKI, Maastor clinic; SMEs
like Philips, Genalice, Cordys,
CSC, Vancis, Roche, Keosys,
OpenClinica; charities KWF, NHS;
institutes like PSI, NBIC,
ICIN,SURFsara;
organisations/projects like
BBMRI, ELIXIR, EATRIS,
BioMedBridges
3
Bitter, W
King Abdallah University, Kaust, Saoudi
Arabia
Arnab Pain
1
Institut Pasteur, Paris, France
Roland Brosch
1
Bakema, JE
Type of
collaboration*
University of Kentucky, Kentucky, United Konstantin Korotkov
States of America
1
EMBL, Hamburg, Germany
1
Annabel Parret
Blauwhoff-Bustermolen, S
University of Alberta, Edmonton, Canada Vickie Baracos, Nina Esfandiari
4
Bleeker, MCG
VUMC, Amsterdam, Netherlands
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 156
Associate
Bloemena, E
Blufpand, H
Boellaard, R
Boers, M
Bontkes, H
Collaborating institute
External collaborator(s)
Type of
collaboration*
AMC, Amsterdam
CGOA (G. Kenter, M. Buist)
1
Kuopio University, Kuopio, Finland
Kuullaa, Aisikanen, Pekka
1
Erasmus MC, Rotterdam
RJ Baatenburg de Jong
1
MUMC, Maastricht
P Lambin
1
Memorial Sloan-Kettering Cancer Center, I. Ganly
New York, USA
1
Sahlgrenska University Hospital,
Kopenhagen, Denmark
G. Stenman
1
Universidade de Oviedo, Oviedo, Spain
M. Hermsen
1
Newcastle University, Newcastle, UK
Ph. Sloan
1
King's college, London, UK
EW Odell
1
Skåne University Hospital, Lund, Sweden
IFCC SD Working group for
Standardisation of Cystatin C,
Anders Grubb (PI)
3
University of Bonn - Medical Center,
Bonn, Germany
Birgit Stoffel-Wagner
1
Nuclear Medicine, University Hospital
Cologne, Cologne, Germany
dr Carsten Kobe
1
CTMM Airforce, Netherlands
see website
3
CTMM Mammoth, Netherlands
see website
3
CTMM TRAIT, Netherlands
see website
3
InMIND, International (FP7)
see website
3
Nuclear Medicine, University Hospital
Dresden, Dresden, Germany
Bernhard Sattler
2
Nuclear Medicine Univ. Vienna, Vienna,
Austria
Thomas Beyer
2
Siemens, Erlangen, Germany
Harald Quick
2
WMIC, Manchester, UK
Rainer Hinz
1
Turku PET Ctr, Turku, Finland
Mika Teras
1
University of Ottawa, Ottawa, USA
Prof P. Tugwell, Prof G. Wells
1
University of Brisbane, Brisbane,
Australia
Prof P. Brooks
1
University of Stanford, Stanford, USA
Prof V. Strand
1
University of Bristol, Bristol, UK
Prof. J. Kirwan, Prof. J. Blazeby
1
University of Edmonton, Edmonton, USA
Prof, W. Maksymovich
1
University of Vienna, Vienna, Austria
Prof. J. Smolen
1
University of Liverpool, Liverpool, UK
Prof. P. Wilkinson
1
University of Copenhagen, Copenhagen,
Denmark
Dr. R. Christensen
1
University of Zaragoza, Zaragoza, Spain
Prof. A. Lanas
1
LUMC, Leiden, Netherlands
Frits Koning
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 157
Associate
Collaborating institute
External collaborator(s)
MUMC, Maastricht, Netherlands
Anita Vreugdenhil
1
Boven, E
VU University Medical Center,
Amsterdam, The Netherlands
Dutch Breast Cancer Research
Group (Borstkanker Onderzoek
Groep; BOOG). D.T. Kruger, S.
Linn, S. Sleijfer, C. Jimenez, E.
Boven (PI).
3
Braakhuis, BJM
Greater Poland Cancer Center, Poznan,
Poland
Dr P. Golusinski
1
University Medical Center Utrecht,
Utrecht, Netherlands
Dr F. Leusink, Dr R. Koole
1
ErasmusMC, Rotterdam, Netherlands
Prof RJ Baatenburg de Jong
1
UMCU, Utrecht, Netherlands
Prof PJ van Diest
1
University of Parma, Parma, Italy
T Poli, KP7 ORAMOD
3
University of Dusseldorf, Dusseldorf,
Germany
K Scheckenbach, KP7 ORAMOD
3
NKI-AvL, Amsterdam, Netherlands
R Bernards
1
NKI-AvL, Amsterdam, Netherlands
H te Riele
1
Sanquin Research, Amsterdam,
Netherlands
Dr. D. Hamann; Dr. D. Wouters;
Prof.dr. T. Kuijpers; Dr. S.
Zeerleder
3
Ziekenhuis Groep Twente, Almelo,
Netherlands
Dutch SLE Registry working
party. Dr. R. Fritsch-Stork, Dr. M.
Bijl, Prof.dr. H. Bootsma, Dr. H.
Bernelot Moens
3
Maastricht University Medical Center,
Maastricht, Netherlands
Prof.dr. J.W. Cohen Tervaert
3
University Medical Center Utrecht,
Utrecht, Netherlands
Prof.dr. T.R.D.J. Radstake
3
Utrecht Institute of Pharmaceutical
Sciences, Utrecht, Netherlands
Dr. F. de Vries, Dr. A.
Lalmohamed, Dr. T.P. van Staa,
Prof.dr. C. Cooper, Dr. N.C.
Harvey
3
Erasmus MC, Rotterdam, Netherlands
Dr. S. Kamphuis
2
MUMC, Maastricht, The Netherlands
Prof. dr. M van Engeland, Dr. V
Melotte, Afdeling Pathologie;
Dr. S Sanduleanu, Prof. dr. AA
Masclee, Afdeling Maag-DarmLever ziekten
1
AMC, Amsterdam, The Netherlands
Dr. E Dekker, Afdeling MaagDarm-Lever ziekten; Dr. JP
Medema, Center for
Experimental Molecular
Medicine; Prof. dr. CJ Punt,
Afdeling Medische Oncologie
3
Erasmus MC, Rotterdam, The
Netherlands
prof.dr. E Kuipers, Afdeling
Maag-Darm-Lever ziekten; Dr. I.
Lansdorp-Vogelaar, Prof. dr. M
van Ballegooijen, Afdeling
volksgezondheid , Prof. Dr. FJ
van Kemenad, Afdeling
Pathologie
3
UMC Nijmegen, Nijmegen, The
prof.dr. ID Nagtegaal, Afdeling
3
Brakenhoff, RH
Bultink, IEM
Carvalho, B
Type of
collaboration*
Appendix Annual Report 2013 VUmc CCA – International collaboration - 158
Associate
Chamuleau, M
Cloos, J
de Boer, Y
Collaborating institute
External collaborator(s)
Type of
collaboration*
Netherlands
Pathologie
LUMC, Leiden, The Netherlands
Dr. PJ Kuppen, Prof. dr. CJH van
de Velde, Afdeling Heelkunde ;
Dr. T van Wesel, Dr. H Morreau,
Afdeling Pathologie
3
Leeds Institute of Molecular Medicine,
University of Leeds, Leeds, UK
Dr. HI Grabsch ; Prof. dr. P
Quirke
3
Institute for Pathology and Molecular
Immunology (IPATIMUP), Porto, Portugal
Dr. C Oliveira, Prof. dr. R Seruca,
Prof. dr. F Carneiro
1
University of Ghent, Ghent, Belgium
prof. dr. W van Criekinge,
Afdeling Mathematical modeling
3
The Sidney Kimmel Comprehensive
Cancer Center at Johns Hopkins
Baltimore, Maryland, US
Prof. Dr. JG Herman
3
UMCG, Groningen, The Netherlands
P. Kluin
3
HOVON, Rotterdam, The Netherlands
oa G. van Imhoff, P. Lugtenburg,
2
Lymmcare, Amsterdam, The
Netherlands
R. van Oers, A. Kater
1
AML-BFM Study Group, Pediatric
Oncology and Hematology, Medical
School Hannover, Hannover, Germany
D. Reinhardt
3
The Fred Wyszkowski Cancer Research
Lab, Technion-Israel Institute of
Technology, Haifa, Israel
Y.G. Assaraf
1
Ontario Cancer Institute, Princess
Margaret Hospital, Toronto, Canada
A. Schimmer
1
Texas Children’s Cancer Center, Baylor
College of Medicine, Houston, USA
T. Horton
3
Center for Human Genetics, Faculty of
Medicine, KU, Center for the Biology of
Disease, VIB, Leuven, Belgium
J. Cools
1
Dutch Autoimmune Hepatitis Study
group, Utrecht, Netherlands
Dutch Autoimmune Hepatitis
Study group. Bart van Hoek,
Karel J. van Erpecum, Ulrich
Beuers, Henk R. van Buuren,
Joost P.H. Drenth, Jannie W. den
Ouden, Robert C. Verdonk, Ger
H. Koek, Johannes T. Brouwer,
Maureen M.J. Guichelaar, Jan M.
Vrolijk
3
University of Groningen, Groningen,
Netherlands
Department of genetics. Cisca
Wijmenga, Lude Franke, Vinod
Kumar, Alexandra Zhernakova
1
University Medicine Greifswald,
Greifswald, Germany
SHIP study (study of health in
Pomerania). Markus M. Lerch,
Matthias Nauck, Henry Völzke,
Georg Homuth
1
University Hospital Leipzig, Leipzig,
Germany
Department of Internal Medicine,
Neurology and Dermatology,
Medical Clinic of
Gastroenterology and
Rheumatology, Section of
Hepatology (Janett Fischer,
Thomas Berg)
2
Appendix Annual Report 2013 VUmc CCA – International collaboration - 159
Associate
de Bree, R
de Gruijl, TD
Collaborating institute
External collaborator(s)
Type of
collaboration*
University Medical Center HamburgEppendorf, Hamburg, Germany
Department of Medicine,
University Medical Center
Hamburg-Eppendorf, Hamburg,
Germany (Christoph Schramm,
Ansgar W. Lohse, Christina
Weiler-Normann)
1
Guy’s Hospital, UK, London
SENT prof.dr. Mark McGurk (p.i.)
3
IRCCS S. Matteo Foundation, University
of Pavia, Italy, Pavia
EURECA prof.dr M. Benazzo (p.i.)
3
Centers of the Dutch Head and Neck
Society, University centers, Netherlands
NWHHT dr. R. Takes (chair
research steering group)
3
Lund University, Lund, Sweden
Dr Anne Sofie Albrekt, Dr Malin
Lindstedt (PI)
1
Washington University, St Louis MO, USA Dr David Curiel
1
Memorial Sloan Kettering Cancer center,
New York City NY, USA
Dr Jedd Wolchock
1
Mt Sinai Hospital, New York City NY,
USA
Dr Sacha Gnjatic
1
Abramson Family Cancer Research
Institute, University of Philadelphia
Philadelphia PA, USA
Dr Daniel Powell jr, Dr Carl June
1
University of Alabama at Birmingham,
Birmingham AL, USA
Dr Qiana Matthews
1
Earle A Chiles Research Institute,
Portland OR, USA
Dr Bernard Fox, Dr Walter Urba
1
Glycostem Therapeutics BV, Den Bosch,
NL
FP7-ITN no. 317013, Dr Jan
Spanholtz, Dr Dirk Groenewegen
(PI)
1
Leiden UMC, Leiden, NL
Prof dr Ferry Ossendorp
1
Radboud UMC, Nijmegen, NL
Dr Hans Koenen
1
Leiden UMC, Leiden, NL
Prof dr Sjoerd van den Burg
1
de Rie, MA
Univ Manchester, Manchester, UK
Griffiths C
3
de Winter JP
Universitat Autònoma de Barcelona,
Barceloma, Spain
J. Surralles
University of Wuerzburg, Wuezburg,
Germany
D. Schindler
Dekker, J
Fred Hutchinson Cancer Research
Center, Seattle, USA
Karen Syrjala
1
den Haan, JMM
University of Nottingham, Nottingham,
United Kingdom
Dr. L. Martinez-Pomares
1
University of Bonn, Bonn, Germany
Dr. A. Limmer
1
University of Dundee, Dundee, United
Kingdom
Dr. P. R. Crocker
1
Robert Koch Institure, Berlin, Germany
Dr. Kroczek
1
1Edinburgh University, 2Medical
University Vienna, 3University of
Innsbruck, 4Kaiser Franz Jozef Hospital,
5Institute Regina Elena
EOL care and QOL in glioma
patients;
Prof. dr. R. Grant, Prof. dr. C.
Marosi, Prof. dr. G.
3
Dirven, L
Appendix Annual Report 2013 VUmc CCA – International collaboration - 160
Associate
Dorsman, JC
Collaborating institute
External collaborator(s)
Type of
collaboration*
1Edinburgh, 2Vienna, 3Innsbruck,
4Innsbruck, 5Rome
1United Kingdom 2,3,4Austria, 5Italy
Stockhammer, Prof. dr. Grisold,
Prof. dr. A. Pace
Erasmus Medical Center, Rotterdam,
Netherlands
HRQoL in the BELOB study; Prof.
dr. M. van den Bent
1
Medical Center Haaglanden, The Hague,
Netherlands
HRQoL, well-being and cognition
in brain tumor patients; E.
Habets, MSc, H. Zwinkels, RN,
MA ANP
1
European Organisation of Research and
Treatment of Cancer, Brussels, Belgium
Review proxy measurements in
HRQoL in cancer, Joint modelling
in HRQoL; Dr. A. Bottomley, D.E.
Ediebah, MSc, Dr. F. Martinelli
1
EORTC Quality of Life Group, Brussels,
Belgium
Developement cancer
survivorship, questionnaire: PIs:
Dr. L. van de Poll-Franse and
Prof. dr. N.K. Aaronson
3
Medical Center Haaglanden, The Hague,
Netherlands
Epilepsy in glioma patients
during the course of disease and
in the EOL; Prof. dr. M.J.B. ,
Taphoorn, J.A.F. Koekkoek, MD,
Dr. M. Vos
1
University of Toronto, Toronto, Canada
B. Gallie
Universitätsklinikum Essen, Essen,
Germany
D. Lohmann
University of Toronto, Toronto, Canada
The Saban Research Institute, Los
Angeles, USA
Fred Hutchinson Cancer Research
Center, Seattle, USA
Institut für Humangenetik,
Universitätsklinikum Essen, Essen,
Duitsland
Douw, L
Martinos Center for Biomedical Imaging
/ MGH, Boston, MA, USA
Steven Stufflebeam
2
Eeltink, C
EBMT, Barcelona, European
CQWP: Complications and
Quality of Life Working Party:
Corien Eeltink PI
2
Fijneman, RJA
University of Minnesota, Duluth, MN &
Minneapolis, MN, USA
Robert T. Cormier, Tim Starr
1
Uppsala University, Uppsala, Sweden
Fredrik Ponten
1
Kennemer Gasthuis, Haarlem, Nederland Hein Stockmann, Herman Bril
1
UMCU, Utrecht, Nederland
Onno Kranenburg
1
Erasmus MC, Service XS, Rotterdam,
Leiden, Nederland
CTMM NGS-ProToCol (Center for
Translational Molecular Medicine
- Next Generation Sequencing:
from Prostate to Colorectal
Cancer) Guido Jenster, Wilbert
van Workum
3
Philips, AMC, Eindhoven, Amsterdam,
Nederland
CTMM DeCoDe (Center for
Translational Molecular Medicine
- Decrease Colorectal cancer
3
Appendix Annual Report 2013 VUmc CCA – International collaboration - 161
Associate
Collaborating institute
External collaborator(s)
Type of
collaboration*
Death - Work Package 2) Rolf
Lamerichs, Hans Hofstraat, Jaap
Stoker
Gibbs, S
Laboratory of Toxicology, DiSFeB,
Università degli Studi di Milano, Milan,
Italy
Prof. E. Corsini
3
Giovannetti, E
Georgetown University, Washington DC,
USA
Prof. Giuseppe Giaccone
1
Vanderbilt-Ingram Cancer Center,
Nashville, TN, USA
Prof. William Pao
1
Technion Institute, Haifa, Israel
Prof. Yehuda Assaraf
1
Imperial College, London, UK
Dr. Adam Frampton
1
Karolinska Institute, Stockholm, Sweden
Prof. Matthias Lohr
1
Marburg University, Marburg, Germany
Dr. Karl Quint
1
Aix-Marseille Univesite', Marseille,
France
Dr. Joseph Ciccolini
1
Universidad de La Laguna, La Laguna,
Spain
FP7 grant. Dr. Leticia Leon, DrJ
Padron
3
University of Pisa - Dept. Surgery,
Oncology and Pathology, Pisa, Italy
PRIN-MIUR, and ITT grant. Prof.
Ugo Boggi, Prof. Daniela
Campani, Dr. Enrico Vasile, Dr.
Niccola Funel
2
University of Pisa - Dept. Pharmaceutical
Sciences, Pisa, Italy
EORTC-PAMM grant. Prof. Filippo
Minutolo
3
Livorno Civic Hospital, Livorno, Italy
Dr. Federico Cappuzzo, Dr.
Carmelo Tibaldi
1
Parma Civic Hospital, Parma, Italy
Prof. Andrea Ardizzoni, Dr.
Marcello Tiseo
1
University of Parma, Parma, Italy
Prof. Piergiorgio Petronini, Dr,.
Roberta Alfieri
1
European Institute of Oncology, Milano,
Italy
Dr. De Pas Tommaso, Dr.
Francesca Toffalorio
1
European Institute of Oncology, Milano,
Italy
Dr. Fedro Peccatori
1
San Raffaele Scientific Institute, Milano,
Italy
Dr. Michele Reni
1
Cancer Center Humanitas, Milano, Italy
Prof. Armando Santoro, Dr. Paolo
Zucali
1
Carrara Civic Hospital, Carrara, Italy
Dr. Paola Pacetti, Dr. Maurizio
Cantore
1
Regina Elena Hospital, Roma, Italy
Dr. Michele Milella
1
University of Roma – Sapienza, Roma,
Italy
Dr. Giovanni Codacci-Pisanelli
1
NKI, Amsterdam, Netherlands
Dr. Rene' Bernards
1
University of Twente, Twente,
Netherlands
Dr. Lorenzo Moroni
1
Erasmus Medical Centre, Rotterdam,
Dr. Henri Braat, Prof. M.
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 162
Associate
Gordijn, MS
Grunberg, K
Heideman, DAM
Collaborating institute
External collaborator(s)
Type of
collaboration*
Netherlands
Peppelenbosch
Wilhelmina Children’s Hospital, Utrecht,
the Netherlands
Dr. M. B. Bierings
3
Academic Medical Center, Amsterdam,
the Netherlands
Dr. C. van den Bos
3
GSK, Zeist, The Netherlands
H. Tamminga
2
IMTA, Rotterdam, The Netherlands
C. Uyl
2
Dpt Epidemiology&Biostatistics, Vumc,
The Netherlands
V. Coupe
2
Abbott, Des Plains, IL, USA
K. Naik
2
UMCU, Utrecht, The Netherlands
S. Willems
3
UMCN, Nijmegen, The Netherlands
I. Nagtegaal
3
PALGA, Houten, The Netherlands
L. Overbeek
3
IARC, Lyon, France
Vaccarella S, De Vuyst H,
Plummer M, Franceschi S, Chen
AA, Gheit T, Tommasino M,
Clifford GM
3
Dept Translational Genomics, University
of Cologne, Cologne,
Germany
R. Thomas
3
NKI, Amsterdam, Netherlands
R. Bernards, S. Horenblas, P.
Nederlof
1
Dept Otolaryngology, IUOPA, Hospital
Universitario Central de Asturias
Oviedo, Spain
M. Hermsen
1
MUMC, Maastricht, The Netherlands
A. Dingemans, EJ Speel
1
UMCG, Groningen, The Netherlands
E. Schuuring, B. Wisman, H.
Groen, A. vd Zee
1
RadboudUMC, Nijmegen, The
Netherlands
H. van Krieken, L. Massuger, H
Bulten, W Melchers, R Bekkers
1
IARC, Lyon, France
Vaccarella S, De Vuyst H,
Plummer M, Franceschi S, Chen
AA, Gheit T, Tommasino M,
Clifford GM
3
Dept Translational Genomics, University
of Cologne, Cologne,
Germany
R. Thomas
3
NKI, Amsterdam, Netherlands
R. Bernards, S. Horenblas, P.
Nederlof
1
Dept Otolaryngology, IUOPA, Hospital
Universitario Central de Asturias
Oviedo, Spain
M. Hermsen
1
MUMC, Maastricht, The Netherlands
A. Dingemans, EJ Speel
1
UMCG, Groningen, The Netherlands
E. Schuuring, B. Wisman, H.
Groen, A. vd Zee
1
RadboudUMC, , Nijmegen, The
Netherlands
H. van Krieken, L. Massuger, H
Bulten, W Melchers, R Bekkers
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 163
Associate
Collaborating institute
External collaborator(s)
Hoekstra, OS
MSKCC, NY, USA
M Morris (PI, project with Royal
Marsden, Monash)
2
Univ of Columbia, NY, USA
L Schwartz
3
Univ of Antwerp, Antwerpen, Belgium
S Stroobants (PI clinical work IMI
Quic-Concept)
2
Radboud, Nijmegen, NL
W Oyen, W de Graaf
3
UMCG, Groningen, NL
EGE de Vries
3
AMC, Amsterdam, NL
C Lavini
1
NCI, NY, USA
RECIST group
3
UMCU, Utrecht, NL
R Nievelstein, W Mali
2
CTMM Airforce, Netherlands
see website
3
CTMM Mammoth, Netherlands
see website
3
Stanford Institute for stem cell biology
and regenerative Medicine
Stanford (CA), USA
Michelle Monje
1
Oregon Health and Science University
(OHSU), Portland (OR), USA
Cure starts now DIPG
consortium. Charles Keller, XiaoNan Li, Jacques Grill, Eric Raabe,
Oren Becher, Michelle Monje,
Paul Spellman (PI's)
3
German Cancer Research Center (DKFZ),
Heidelberg, Duitsland
Marcel Kool
1
BRIC, Copenhagen, Denmark
Anders Lund
1
The Institute of Cancer Research (ICR),
London, UK
European DIPG Network Molecular Biology division. Chris
Jones, Marta Alonso, Angel
Montero-Carcaboso, Pascal
Johann
3
UMCG, Groningen, The Netherlands
Sabine Plasschaert
1
Centro Medico nacional siglo XXI,
Mexico-city, Mexico
Enrique Lopez
1
ErasmusMC, Rotterdam, The
Netherlands
Peter van der Spek
1
Baylor College of Medicine, Houston
(TX), USA
Xiao-Nan Li
1
UMC Groningen, Groningen,
Netherlands
ESJM de Bont
2
UMC Nijmegen, Nijmegen, Netherlands
CG Gidding
2
Great Ormond Street Hospital, London,
UK
D Hargrave
2
UCLH, London, UK
J Bomanji
2
Gottingen University Hospital,
Gottingen, Germany
C Kramm
1
University of Wurzburg, Wurzburg,
Germany
M Warmuth-Metz
1
Netherlands Cancer Institute,
Prof. Dr. JJ Neefjes
3
Huisman, M
Hulleman, E
Jansen, MHA
Janssen, JJWM
Type of
collaboration*
Appendix Annual Report 2013 VUmc CCA – International collaboration - 164
Associate
Collaborating institute
External collaborator(s)
Type of
collaboration*
Amsterdam, NL
Jimenez, CR
Kaspers, GJL
Dept of Hematology, Helsinki, Finland
Dr S. Mustjoki; Prof. Dr K. Porkka
1
Dept of Hematology, Lund, Sweden
Dr. J. Richter
1
Dept of Hematology, Trondheim,
Norway
Dr. H. Hjorth-Hansen
2
Dept of Hematology, Nijmegen, NL
Dr. A. Schattenberg
2
Netherlands Cancer Institute,
Amsterdam, The Netherlands
Dr. Jos Jonkers
1
Netherlands Cancer Institute,
Amsterdam, The Netherlands
Prof. Dr. Anton Berns
1
Netherlands Cancer Institute,
Amsterdam, The Netherlands
Dr. Olaf van Tellingen
1
AMC, Amsterdam, The Netherlands
Prof. Dr. Jan Paul Medema
1
UMCU, Utrecht, The Netherlands
Dr. Onno Kranenburg
1
VU, Amsterdam, The Netherlands
Dr. Bert de Boer
1
RIVM, Bilthoven, The Netherlands
Dr. Wendy Rodenburg
1
VanderBilt University Medical School,
Nashville, USA
Dr. Robbert Slebos
1
VUmc coordinator Guus van Dongen,
Amsterdam, The Netherlands
CTMM Airforce consortium
members
3
VUmc coordinator Gerrit Meijer,
Amsterdam, The Netherlands
CTMM DeCoDe consortium
members
3
VUmc coordinator Gerrit Meijer,
Amsterdam, The Netherlands
CTMM TraIT consortium
members
3
UMCU-NKI-ErasmusMC, The Netherlands
Center for Personalized Cancer
Treatment
3
Stichting kinderoncologie Nederland
(SKION), Den Haag, Nederland
Dr. E. Sonneveld
Dr. V. de Haas
1
Erasmus MC - Sophia kinderziekenhuis,
Rotterdam, Nederland
Dr.C.M. Zwaan
Dr. M van den Heuven-Eibrink
Dr. M.L. den Boer
Dr. Prof. dr. R. Pieters
1
EKZ – AMC, Amsterdam, Nederland
Prof. dr. H.N. Caron
Dr. A.Y.N. Schouten-van
Meeteren
Prof. dr. M.
Grootenhuis
1
UMCG / Beatrix Kinderkliniek,
Groningen, Nederland
Prof. dr. E.S.J.M. de Bont
1
Sanquin, Amsterdam, Nederland
Dr. T. van den Berg
1
UMCU / WKZ, Utrecht, Nederland
Dr. M. Bierings
Drs. A.B. Versluijs
1
INKL-werkgroep kindertumoren
Amsterdam, Amsterdam, Nederland
M. jansen - Landheer
1
The Childeren’s Hospital, Westmead,
Sydney, Australië
L. Dalla‐Pozza & R.
Howman‐Giles
3
Center for Human Genetics, Faculty of
J. Cools
3
Appendix Annual Report 2013 VUmc CCA – International collaboration - 165
Associate
Collaborating institute
External collaborator(s)
Type of
collaboration*
Medicine, KU Leuven, België
Princess Margaret Hospital, Ontario
Cancer Institute, Toronto, ON, Canada
A.D. Schimmer
3
Hospital Skejby, Aarhus University,
Aarhus, Denemarken
H. Hasle
3
AML‐BFM Group, Hannover, Duitsland
U. Creutzig & D. Reinhardt
3
German COALL Group, Hamburg,
Duitsland
G. Escherich & G. Janka‐Schaub
3
German BFM‐relapse ALL Study Group,
Berlijn, Duitsland
Prof. G. Henze & Dr. A.
Stackelberg
3
Bonn University Medical Center, Bonn,
Duitsland
B. Stoffel‐Wagner
3
I‐BFM‐SG, London UK, Hannover,
Duitsland
D. Webb & M. Zimmerman
3
European DIPG network, Europa,
div.
3
UK – CCLG, Birmingham + Glasgow,
Groot Brittannië
P. Kearns & Dr. B. Gibson
3
University of Sumatera Utara, Medan ,
Indonesië
Prof. Bidasara Lubis
3
Universitas Diponegoro,dept of
pediatrics, Semarang, Indonesië
Prof. Ag. Soemantri
3
Universitas Diponegoro,center for
biomedical research, Semarang,
Indonesië
Prof. Sultana M.H. Faradz
3
Universitas Kristen Indonesia, Djakarta,
Indonesië
Emelyana Pane
3
Sam Ratulangi University, Dept of
Pediatrics, Manado, Indonesië
Prof. Max F.J. Mantik & Dr S.
Gunawan
3
Universitas Gadjah Mada, Yogjakarta,
Indonesië
Prof. Sutaryo & E. Supriyadi &
M.N. Sitaresmi & P.H. Widjajanto
3
Institute of Technology University, Haifa, Y.G. Assaraf, Technion‐Israel
Israël
3
AIEOP, Rome & Bologna, Italië
A. Tésti & Prof. A. Pession
3
MTRH, Eldoret, Kenia
F. Njuguna
3
University of Malawi, Blantyre, Malawi
E. Molyneux
3
National University of Singapore,
Singapore, Singapore
WJ Chng
3
National University Hospital Singapore,
Singapore, Singapore
Prof. Allen Eng‐Yuh Yeoh
3
Harvard Medical School, Cambridge,
Massachusetts, Verenigde Staten
B.A. Tannous
3
Fred Hutchinson Cancer Research
Center, Seattle, Washington, Verenigde
Staten
S. Meshinchi
3
Baylor College of Medicine/Texas
Children's Cancer Center, Houston,
Texas, Verenigde Staten
T. Horton
3
Appendix Annual Report 2013 VUmc CCA – International collaboration - 166
Associate
Collaborating institute
External collaborator(s)
Scripps Institution of Oceanography &
Skaggs School of Pharmacy and
Pharmaceutical Sciences, University of
California, San Diego, California,
Verenigde Staten
B.S. Moore
3
St. Jude Children’s Research Hospital,
Memphis, Tennesee, Verenigde Staten
R.R. Ribeiro & B. Razzouk
3
Indiana University, Ampath Oncology
Institute, Indianapolis, Indiana,
Verenigde Staten
J. Skiles, T. Vik, P. Loehrer
3
Kenter, GG
Centre Curie, Paris, France
RAID EU project in 7 EU
countries
3
Kerkhoff, N
Kings College Hospital, London, United
Kingdom
Prof. G. Mufti and Dr. S. Kordasti
1
Lund University, Lund, Sweden
Dr. M. Lindstedt
1
Westfälische Wilhelms-Universität
Münster, Münster, Germany
INMiND (Imaging of
Neurodegeneration in
Neurodegenerative Diseases)
involving 21 academic
institutions and 6 SMEs from 13
countries
1
Center for Integrated Oncology
Köln/Bonn, Köln, Germany
Prof. dr. J. Wolf
1
Divisie farmacologie, Leiden,
Netherlands
Dr. E.C. De Lange
1
Stichting Epilepsie Instellingen
Nederland, Heemstede, Netherlands
Dr. R.A. Voskuyl
1
Uppsala University, Uppsala, Sweden
Dr. M. Lubberink, dr. S. Syvänen
1
Ludwig-Maximilians Universität,
München, Germany
Prof. dr. H. Potschka
1
UCL Institute of Neurology, London, UK
Prof. dr. M. Koepp
1
Israel Institute for Biological Research,
Ness-Ziona, Israel
Prof. dr. A. Fisher
1
Karolinska Institutet, Stockholm,
Sweden
Dr. A. Varrone, Prof. dr. C.
Halldin
1
AMC, Amsterdam, Netherlands
Prof. dr. D. Denys
1
UMC Utrecht, Utrecht, Netherlands
Prof. dr. R.S. Kahn
1
Department of Radiation Oncology,
University Medical Center Groningen
Groningen, The Netherlands
J.A. Langendijk
1
Laboratories of Experimental Surgery,
Brussels Free University
Brussel, Belgium
M. Hacquebard
1
Department of Clinical Medicine –
Sapienza, University of Rome
Rome, Italy
M. Muscaritoli
1
Centre for Dietetics Research, School of
Human Movement Studies, University of
Queensland, Brisbane, Australia
J.D. Bauer, E.A. Isenring
1
Lammertsma, AA
Langius, JAE
Mebius, R
Instituto de Medicina Molecular,
Type of
collaboration*
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 167
Associate
Collaborating institute
External collaborator(s)
Type of
collaboration*
Faculdade de Medicina de Lisboa,
Lisbon, Portugal
Meijer, CJLM
Babraham Institute, Cambridge, UK
1
UMC Utrecht, Utrecht, Netherlands
1
Cold Spring Harbor Laboratories, Cold
Spring Harbor, USA
1
NYU, New York, USA
1
Monash University, Clayton , Australia
1
Hubrecht Laboratories, Utrecht,
Netherlands
1
Città della salute e della scienza di
Torino (AOT), Turin, Italy
Unit for cervical cancer
evaluation: Guglielmo Ronco
3
Karolinska Institute, Stockholm, Sweden
Joakim Dillner, Miriam Elfström
3
Queen Mary & Westfield College
(QMUL), University of London
London, UK,
Jack Cuzick, Attila Lorincz,
Louise Cadman
3
Virus, Lifestyle and Genes, Danish
Cancer Society Research Center
Copenhagen , Denmark
Christian Munk
3
University of Tampere, Tampere, Finland Matti Lehninen, Pekka Nieminen,
Vänskä Simopekka
3
LUMC, Leiden, Netherlands
Sjoerd van den Burg, Dept
Clinical Oncology
1
UMC Groningen, Groningen,
Netherlands
Ate van der Zee, Bea Wisman,
Dept Gynaecology
1
UMC St. Radboud, Nijmegen,
Netherlands
Willem Melchers, Ruud Bekkers,
Leon Massuger, Dept.
Gynaecology & Medical
Microbiology
3
UMC Utrecht, Utrecht, Netherlands
Rene Verheijen, Dept.
Gynaecology
3
Erasmus MC, Rotterdam, Netherlands
Folkert van Kemenade, Dept.
Pathology
3
Curacao
Bob Pinedo
3
Univerza V Ljubljani, Ljubbljiana,
Slovenia
Mario Poljack
3
Denmark
Prof. Kraeftens
3
AMC, Amsterdam, Netherlands
Henri de Vries, Jan Prins, Depts.
Dermatology, Infectious
Diseases
1
University of Michigan Medical School,
Ann Arbor, USA
B.D. Athey
Data Science Institute, Imperial College,
London , UK
Y. Guo
University of Minnesota, Duluth, MN &
Minneapolis, MN, USA
Robert T. Cormier, Tim Starr
1
Uppsala University, Uppsala, Sweden
Fredrik Ponten
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 168
Associate
Middeldorp, JM
Collaborating institute
External collaborator(s)
Type of
collaboration*
Kennemer Gasthuis, Haarlem, Nederland Hein Stockmann, Herman Bril
1
UMCU, Utrecht, Nederland
Onno Kranenburg
1
Erasmus MC, Service XS, Rotterdam,
Leiden, Nederland
CTMM NGS-ProToCol (Center for
Translational Molecular Medicine
- Next Generation Sequencing:
from Prostate to Colorectal
Cancer) Guido Jenster, Wilbert
van Workum
3
Philips, AMC, Eindhoven, Amsterdam,
Nederland
CTMM DeCoDe (Center for
Translational Molecular Medicine
- Decrease Colorectal cancer
Death - Work Package 2) Rolf
Lamerichs, Hans Hofstraat, Jaap
Stoker
3
CTMM-TraIT, federated organisation, NL
Public private partnership: all
UMCs, NKI, Maastor clinic; SMEs
like Philips, Genalice, Cordys,
CSC, Vancis, Roche, Keosys,
OpenClinica; charities KWF, NHS;
institutes like PSI, NBIC,
ICIN,SURFsara;
organisations/projects like
BBMRI, ELIXIR, EATRIS,
BioMedBridges
3
Sidney Kimmel Comprehensive Cancer
Center at Johns Hopkins
Baltimore, USA
J.G. Herman, S. Bayling
1
LIMM, University of Leeds, Leeds, UK
P. Quirke, H. Grabsch
1
Johns Hopkins School of Medicine,
Baltimore, USA
D. Sidransky, V. Velculescu
1
Center for Cancer Research, National
Cancer Institute
Bethesda, USA
G. Giaccone
1
IPATIMUP, Porto, Portugal
C. Oliveira
1
KU Leuven, Leuven, Belgium
S. Tejpar
1
The EMBL-European Bioinformatics
Institute, Hinxton, UK
BioMedBridges: Janet Thornton,
Niklas Blomberg, Christian
Ohman
3
Netherlands Cancer Institute, Dept.
Head & Neck Surgery, Amsterdam,
Netherlands
Prof.dr. I.B.Tan, Dr. J.P de Boer,
dr. A.Huitema, dr. S.Stoker
3
Netherlands Cancer Institute, Dept.
Tumor Cell Biology, Amsterdam,
Netherlands
prof.dr. J.J.Neefjes
1
University Medical Center, Dept.
Experimental Virology, Utrecht,
Netherlands
prof.dr. E. Wiertz, dr. M.Ressing
1
Tuft's University, Dept. Pathology,
Boston, USA
prof.dr. D.Thorley-Lawson
1
University of London, Imperial College,
Dept. medicine, London, UK
prof.dr. M.Allday, dr. E.Paschos,
dr. R.White
1
University of Birmingham, Dept. Cancer
Studies, Birmingham, UK
prof.dr. A.Rickinson, prof.dr.
M.Rowe, dr. P.Murray, dr.
N.Blake, dr. A.Hislop
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 169
Associate
Collaborating institute
External collaborator(s)
Type of
collaboration*
University of Hong Kong, Dept.
Anatomy and Pediatrics, Hong Kong,
China
prof.dr. S.W.Tsao, prof.dr.
A.K.Chiang
1
Seoul national University, Dept
Pathology, Seoul, Korea
prof.dr. M.S.Chang
1
University of Wisconsin, Dept. Oncology, prof.dr. S.Kenney
Madison, USA
1
National Cancer Institute, Rockville, USA
prof.dr. A.Hildesheim, dr.
C.Chang, dr. K.Yu
3
Karolinska Institute, Dept. Microbiology
and Tumor Biology, Stockholm, Sweden
prof.dr. I.Ernberg, dr. LF Hu
3
Karolinska Institute, Dept. Microbiology
and Tumor Biology, Stockholm
Sweden
prof.dr. M.Masucci
1
Gadjah Mada University, Dept Medicine,
Yogyakarta, Indonesia
prof.dr. S.M.Haryana, dr.
S.Hutajulu, dr. J.Fachiroh, dr.
J.Kurnianda
3
Universitas Indonesia, Dept. Head &
Neck Surgery, Jakarta, Indonesia
prof.dr. B.Hermani, prof.dr.
S.Gondhowiyardjo, dr.
L.Rachmani, dr. A.Roezin,
prof.dr. AN Kurniawan
1
University of Ottawa, Dept. Pathology
and Laboratory Medicine, Ottawa,
Canada
dr. J.M.Woulfe, dr. DA.Gray
1
University of Toronto, Dept. Molecular
Genetics, Toronto, Canada
Prof.dr. L.Frappier
1
Makarere University, Dept. Medical
Sciences, Kampala, Uganda
dr. J.Orem, Prof.dr. E.Weiderpass
3
State University New York, Syracuse,
USA
prof.dr. M.Rochford, dr. E.Piriou
3
Moll, A
Universitätsklinikum Essen, Essen,
Germany
Petra Temming
4
Mooi, WJ
University of Chicago, Chicago, USA
Prof T.S. Krausz
4
University of London, London, GB
Dr E. Calonje
4
University of Leiden, Leiden, NL
prof W. Bergman
1
Reumatology, VUmc, Amsterdam,
Netherlands
Dr. Irene van der Horst
3
Gastroenterology, VUmc, Amsterdam,
Netherlands
Dr. A. van Bodegraven
3
Gynaecology, UMCG, Groningen,
Netherlands
Prof.dr. J. Land
3
Gynaecology, UMCG, Maastricht,
Netherlands
Dr. J den hartog, Prof. H Evers
3
GGD Amsterdam, Amsterdam,
Netherlands
Dr. S Bruisten, Dr. M. van der
Loeff
3
GGDZL, Heerlen, Netherlands
Prof.dr. C. Hoebe, Dr. N. Dukers
3
RIVM, Bilthoven, Ntherlnads
Dr. M. van der Sande
1
AMC, Amsterdam, Netherlands
Prof.dr. H. de Vries
3
Morré, SA
Appendix Annual Report 2013 VUmc CCA – International collaboration - 170
Associate
Collaborating institute
External collaborator(s)
Wuhan Hospital, Wuhan, China
Prof. B. Xia
1
California Universities, LA, SF, Merced,
CA, USA
Prof.dr. D. Dean. Prof.dr. D
Ojccius, Dr. L de la Maza
3
ICTI Consortium, NL, EU, USA, EU, USA
20 partners
3
Chlamydia Lab RIVM, Amsterdam,
Netherlands
8 partners
2
CDC, Atlanta, USA
Prof.dr. J. Iegitseme
1
University of Helsinki, Helsinki, Finland
Prof.dr. J. Paavonen
3
Kastelli Centre, Oulu, Finland
Dr. H-J. Surcel
3
EpiGenChlamydia, NL, EU, USA, EU, USA
20 partners
3
Neefjes, ECW
Academisch hospice Demeter, de Bilt,
Netherlands
Saskia Teunissen
2
Ossenkoppele, GJ
University of Ulm, Ulm, Germany
Prof dr Dohner
2
Erasmus Mc, Rotterdam, Netherlands
prof dr B.Lowenberg
1
Fred Hutchinson Cancer Research
Institute, Seattle, USA
Dr E Estey
2
Pegtel, M
Peters, GJ
Type of
collaboration*
European leukemia net, Mannheim,
Germany
3
HOVON, Rotterdam, The Netherlands
2
Netherlands Cancer Institute,
Amsterdam, Netherlands
Sjaak Neefjes
1
Hubrecht Laboratory, Utrecht,
Netherlands
Jacco v Rheenen, Anoek Zomer
1
University of Granada, Granada, Spain
Michael Hackenberg
1
Harvard University, Boston, USA
Xandra Breakefield
1
University of Amsterdam, Amsterdam,
Netherlands
Rienk Nieuwland
1
Utrecht University, Utrecht, Netherlands
Ramon Schiffelers
1
VU University, Amsterdam, Netherlands
Matthijs Verhage, Ruud Toonen
1
Tufts University, Boston, Netherlands
David Thorley-Lawson
1
University of Amsterdam, Amsterdam,
Netherlands
Ineke ten Berge
1
Univeristy of Bologna, Bologna, Italy
COST (European Stem Cell
Network)
1
NKI, Amsterdam, Netherlands
Prof. Dr. René Bernards
1
University of Twente, Twente,
Netherlands
Dr. Lorenzo Moroni
1
Rega Institute, Leuven, Belgium
Prof. dr. J. Balzarini
1
EORTC Tranlational research Division,
Brussels, Belgium
Dr. J. Hall
1
Max-Delbrück-Center for Molecular
Medicine, Berlin-Buch, Germany
Dr. I. Fichtner
1
University of Pisa, Pisa, Italy
Prof. Dr. R. Danesi
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 171
Associate
Collaborating institute
External collaborator(s)
Type of
collaboration*
University of Pisa, Pisa, Italy
Dr. N. Funel
1
National Cancer Institute, Bari, Italy
Prof. dr. A. Paradiso
1
University of Pisa - Dept. Pharmaceutical
Sciences, Pisa, Italy
EORTC-PAMM grant. Prof. Filippo
Minutolo
3
Parma Civic Hospital, Parma, Italy
Prof. Andrea Ardizzoni, Dr.
Marcello Tiseo
1
University of Parma, Parma, Italy
Prof. Piergiorgio Petronini, Dr.
Roberta Alfieri
1
European Institute of Oncology, Milano,
Italy
Dr. Fedro Peccatori
1
Cancer Center Humanitas, Milano, Italy
Prof. Armando Santoro, Dr. Paolo
Zucali
1
University of Roma – Sapienza, Roma,
Italy
Dr. Giovanni Codacci-Pisanelli
1
Aix-Marseille Univesite', Marseille,
France
Dr. Joseph Ciccolini
1
University of Barcelona, Institute of
Biomedicine and Oncology Programme,
Barcelona, Spain
Prof. Dr. Marcal Pastor-Anglada,
PhD
1
Universidad de La Laguna, La Laguna,
Spain
FP7 grant. Dr. Leticia Leon, Dr. J
Padron
3
University of Bradford, Bradford, United
Kingdom
R. Phillips, PhD
1
Agricultural University, Uppsala, Sweden
Prof. dr. S. Eriksson
1
Center for Drug Design and Discovery,
SVERI’s College of Pharmacy,
Pandharpur, India
Prof. Dr. Y. Mayur
1
Technion Institute, Haifa, Israel
Prof. Yehuda Assaraf
1
Barbara Ann Karmanos Cancer Institute,
Detroit, USA
Larry H. Matherly, PhD
1
Georgetown University, Washington DC,
USA
Prof. Giuseppe Giaccone
1
Vanderbilt-Ingram Cancer Center,
Nashville, TN, USA
Prof. William Pao
1
NCI, Bethesda, MD, USA
Dr. G. Giaconne & Victor
Marquez, Ph.D.
1
Postma, TJ
universita Bicocca, Milan, Italy
prof dr Cavaletti
3
Reijneveld, JC
European Association of NeuroOncology
Member, USA
Chang, S.M., Costello J.
1
Hospital Salpetrière, Paris, France
Idbaih, A., Hoang-Xuan K.,
1
University of Edinburgh, Edinburgh, UK
Grant, R., Rooney, A.G.,
1
Medical University of Vienna, Vienna,
Austria
Marosi, C., Preusser, M.,
1
Medical University of Innsbruck,
Innsbruck
Austria
Stockhammer, G.
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 172
Associate
Collaborating institute
External collaborator(s)
Rozendaal, L
AMC, Amsterdam, Netherlands
JJMCH de la Rosette MD PhD
1
EMC, Rotterdam, Netherlands
FJ van Kemenade MD PhD
1
AML-MRD working party, Rotterdam,
Nijmegen, Enschede, Leuven,
Netherlands, Belgium
Vincent van der Velden, Rik
Brooimans, Frank Preijers,
Jennita Slomp, Nancy Boeckx
Erasmus Medical Center, Rotterdam,
Netherlands
Peter Valk, Bob Löwenberg,
Mojca Jongen
1
HOVON/SAKK Consortium, sGravendijkwal, 230 3015 CE Rotterdam
Netherlands
Principle collaborators of >40
centers in 7 different countries
2
Utrecht University Medical Center,
Utrecht, Netherlands
Anton Martens, Richard Groen
1
Academic Medical Center, Amsterdam,
The Netherlands
dr. N.A.P. Franken, dr. L.J.A.
Stalpers
1
Maastricht University / Maastricht,
university Medical Center, Maastricht,
The Netherlands
Dr. J. Theys, Prof. dr. B.G.
Baumert, Ing. K. Paesmans
1
University of California, San Francisco,
USA
Prof. dr. D. Haas-Kogan
1
Technical University, Delft, The
Netherlands
Dr. A. Denkova, Prof. dr. B.
Wolterbeek
1
Clinical Cooperation Unit
Neurooncology, MediClin Robert Janker
Klinik & University of Bonn Med Center,
Bonn, Germany
Prof. dr. B.G. Baumert
1
Institute of Biochemistry, University of
São Paulo, São Paulo, Brazil
dr. C.A. Fedrigo
1
Department Clinical Oncology, Assuit
University Hospital, Assuit, Egypt
dr. M. Elnaggar
1
Medical University of Graz, Graz, Austria
Dr. V. Strenger
4
Department of Radiation Oncology &
Research Unit, Dr. Negrin University
Hospital, Las Palmas, Canary Islands,
Spain
Dr. B. Clavo
4
Netherlands Cancer Institute,
Amsterdam, The Netherlands
Dr. C.Vens, dr. O. van Tellingen
3
Schuurhuis, GJ
Sminia, S
Smit, L
Type of
collaboration*
Beatson West of Scotland Cancer Center, Prof. dr. A. Chalmers
Glasgow, UK
3
:eeds Institute of Molecular Medicine,
section oncology and clinical research.
University of Leeds, Leeds , UK
Prof. dr. S. Short
3
Oncomatrix Research Laboratory,
Department of Biomedicine, University
of Bergen, Bergen, Norway
Prof. dr. R.J. Bjerkvig, dr. P Enger
3
Leiden University Medical Center
Leiden, The Netherlands
dr. J. Wondergem
3
University Medical Center Groningen
Groningen, The Netherlands
Prof. dr. R.P. Coppes
3
Netherlands Cancer Institute
Amsterdam, The Netherlands
Prof. R. Bernards/Dr. R.
Beijersbergen
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 173
Associate
Snijders, PJF
Steenbergen, R
Collaborating institute
External collaborator(s)
Type of
collaboration*
Netherlands Cancer Institute
Amsterdam, The Netherlands
Dr. R. Kerkhoven
1
Netherlands Cancer Institute
Amsterdam, The Netherlands
Dr. P. Celie
1
UMCU, Utrecht, The Netherlands
Dr. M. Maurice
1
UMCU, Utrecht, The Netherlands
Prof. A. Martens
1
Academic Medical Center, Amsterdam
The Netherlands
Dr. B. Blom
1
Erasmus University, Rotterdam, The
Netherlands
Prof. P. Valk
1
Institut Suisse de Recherche
Experimentale sur le Cancer ( ISREC),
Lausanne, Zwitserland
Prof. M. de Palma
1
Netherlands Cancer Institute,
Amsterdam,
The Netherlands
Prof. J. Neefjes
1
Città della salute e della scienza di
Torino (AOT), Turin, Italy
Unit for cervical cancer
evaluation: Guglielmo Ronco
3
Karolinska Institute, Stockholm, Sweden
Joakim Dillner
3
Queen Mary & Westfield College (QMUL),
University of London, London, UK
Jack Cuzick, Attila Lorincz
3
University of Tampere, Tampere, Finland Matti Lehninen, Pekka Nieminen
3
DKFZ, Heidelberg, Germany
Frank Rösl, Michael Pawlita
1
LUMC, Leiden, Netherlands
Sjoerd van den Burg, Dept
Clinical Oncology
1
UMC Groningen, Groningen,
Netherlands
Ate van der Zee, Bea Wisman,
Dept Gynaecology
1
UMC St. Radboud, Nijmegen,
Netherlands
Willem Melchers, Ruud Bekkers,
Leon Massuger, Dept.
Gynaecology & Medical
Microbiology
3
UMC Utrecht, Utrecht, Netherlands
Rene Verheijen, Dept.
Gynaecology
3
Erasmus MC, Rotterdam, Netherlands
Folkert van Kemenade, Dept.
Pathology
3
University of Alabama et Birmingham
Birmingham, USA
Tom Broker, Louise Chow
1
University of Cologne, Cologne,
Germany
Roman Thomas
3
AMC, Amsterdam, Netherlands
Henri de Vries, Jan Prins, Depts.
Dermatology, Infectious
Diseases
1
The Norwegian Radium Hospital, Oslo,
Norway
H Lyng
1
Institute of Bioengineering , Swiss
Federal Institute of Technology (EPFL),
Lausanne, Switzerland
B. Deplancke
1
Laboratory for Bioinformatics and
W van Criekinge
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 174
Associate
Collaborating institute
External collaborator(s)
Type of
collaboration*
Computational Genomics, Gent, Belgium
Taphoorn, MJB
te Riele, H
Unger, W
Dept. Tumorvirology, DKFZ, Heidelberg,
Germany
F. Rösl
1
Dept. of Biochemistry and Molecular ,
Genetics, UAB, Birmingham, USA
T.R. Broker, L.T. Chow
1
Dept. Clinical Oncology, Leiden
University Medical Center, Leiden,
Netherlands
SH vd Brug
1
Dept. Gynaecological Oncology,
University Medical Center Groningen,
Groningen, Netherlands
A vd Zee, GB Wisman
1
Division of Gene Regulation, Dutch
Cancer Institute, Amsterdam,
Netherlands
R Agami
1
1Edinburgh University, 2Medical
University Vienna, 3University of
Innsbruck, 4Kaiser Franz Jozef Hospital,
5Institute Regina Elena, 1Edinburgh,
2Vienna, 3Innsbruck, 4Innsbruck,
5Rome, 1United Kingdom 2,3,4Austria
5Italy
EOL care and QOL in glioma
patients;
Prof. dr. R. Grant, Prof. dr. C.
Marosi, Prof. dr. G.
Stockhammer, Prof. dr. Grisold,
Prof. dr. A. Pace
3
Erasmus Medical Center, Rotterdam,
Netherlands
HRQoL in the BELOB study; Prof.
dr. M. van den Bent
1
Medical Center Haaglanden, The Hague,
Netherlands
HRQoL, well-being and cognition
in brain tumor patients;
E. Habets, MSc, H. Zwinkels, RN,
MA ANP
1
European Organisation of Research and,
Treatment of Cancer, Brussels, Belgium
Review proxy measurements in
HRQoL in cancer, Joint modelling
in HRQoL; Dr. A. Bottomley, D.E.
Ediebah, MSc, Dr. F. Martinelli
1
EORTC Quality of Life Group, Brussels,
Belgium
Developement cancer
survivorship questionnaire: PIs:
Dr. L. van de Poll-Franse and
Prof. dr. N.K. Aaronson
3
Medical Center Haaglanden, The Hague,
Netherlands
Epilepsy in glioma patients
during the course of disease and
in the EOL; Prof. dr. M.J.B.
Taphoorn, J.A.F. Koekkoek, MD,
Dr. M. Vos
1
University of Düsseldorf, Düsseldorf,
Germany
A. Borkhardt
University of Toronto, Toronto, Canada
C.E. Pearson
1
UMCG, Groningen, Netherlands
Martijn Nawijn
1
EMC, Rotterdam, Netherlands
Bart Jacobs, Ruth Huizinga
1
VUmc, Amsterdam, Netherlands
Elga de Vries
1
VUmc, Amsterdam, Netherlands
Tanja de Gruijl
1
VUmc, Amsterdam, Netherlands
Jantine Bakema
1
Children’s Hospital Los Angeles, Los
Angeles, USA
Joe Church
1
Twincore Institute, Hannover, Germany
Tim Sparwasser, Luciana Berod,
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 175
Associate
Collaborating institute
External collaborator(s)
Type of
collaboration*
Christian Mayer
van Beusechem, VW
van de Sar, AM
van de Wiel, M
van den Elsen, PJ
van der Laken, J
Van der Waal, I
Dept. Neurosurgery, ErasmusMC,
Rotterdam, Netherlands
Clemens Dirven, Martine Lamfers
2
Institut Catala d'Oncologia, Barcelona,
Spain
Ramon Alemany
1
UniversitatsSpital Zurich, Zurich,
Switzerland
Rolf Stahel, Emanuela FelleyBosco
1
Dept. Radiotherapy, NKI, Amsterdam,
Netherlands
Marcel Verheij, Baukelien van
Triest
1
UMCN St. Radboud, Nijmegen,
Netherlands
Winald Gerritsen, Jelle Barentsz
1
University of Tampere, Tampere, Finland Mataleena Parikka PhD
1
Global Health Institute, Ecole
Polytechnique Fédärale de Lausanne,
Lausanne, Switzerland
1
Stewart T Cole
University of Liverpool, Liverpool, United PreDiCT-TB (IMI= Innovative
Kingdom
Medicine Initiative Europe)
consortium. Gerry Davies,
Stewart R. Cole, Stefan
Kaufmann, John McKinney,
Stephen Gillispie
3
University of Birmingham, Birmingham,
United Kingdom
Del Besra
1
University of Zurich, Zurich, Switzerland
Mark Robinson
1
NTNU, Trondheim, Norway
Andrea Riebler
1
Imperial College, London, UK
Gerry Thomas
3
Leiden University Medical Center,
Leiden, Netherlands
Martine Jager (Ophthalmology)
1
Leiden University Medical Center,
Leiden, Netherlands
Peter Kuppen (Churgery)
1
Texas A&M Health Science Center,
College Station, USA
Koichi Kobayashi
1
Leiden University Medical Center,
Leiden, Netherlands
Sylvere van der Maarel (Human
Genetics)
1
Leiden University Medical Center,
Leiden, Netherlands
Hermelijn Smits (Parasitology)
1
Charité, Berlin, Germany
Gunther Schonrich
1
PI: UMCU, rheumatology, Utrecht,
Netherlands
CTMM TRACER: National
collaboration of 6 universities
and LE/SMEs
1
PI: ETH, Zurich, Switserland
FP7 project PRIAT; collaboration
of 7 european partners
1
Department of Oral and Maxillofacial
Surgery, Leiden, The Netherlands
1
Netherlands Cancer Institute,
Amsterdam, The Netherlands
1
Department of Dermatology, Sint
Antonius , Ziekenhuis, Nieuwengein,
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 176
Associate
Collaborating institute
External collaborator(s)
Type of
collaboration*
Netherlands
van Die, I
van Dulmen-den Broeder,
E
Swammerdam Institute for Life Sciences,
University of Amsterdam, Amsterdam,
Netherlands
1
Department of ENT, Dental
Ophthalmological, and Cervicofacial
Sciences, University of Parma, Unit of
Oral Pathology and Medicine, section of
Odontostomatology, Parma, Italy
1
Department of Oral Surgery, University
of Porto
Porto, Portugal
1
Department of Oral Medicine, Carolina
Medical Center, Carolina, USA
1
Department of Clinical Epidemiology
and Biostatistics, VUmc, Amsterdam,
Netherlands
1
Department of Clinical Genetics, VUmc
Amsterdam, Netherlands
1
Department of Otolaryngology/Head
and Neck Surgery, VUmc, Amsterdam,
Netherlands
1
Department of Biomedical Engineering,
University of Groningen and University
Medical Center Groningen
Groningen, Netherlands
1
Department of Oral and Maxillofacial
Surgery, UMC
Groningen, Netherlands
1
Department of Oral and Maxillofacial
Surgery UMC
Utrecht, Netherlands
1
Section for Parasitology, University of
Copenhagen
Copenhagen, Denmark
Helene Kringel
1
Dept. Biochemistry, Emory University
School of Medicine, Atlanta, USA
Richard D. Cummings
1
Dept. of Medical Microbiology, UMC
Utrecht
Utrecht, The Netherlands
Harm Snippe
1
Laboratory of GlycoNanotechnologyCIC
biomaGUNE
San Sebastián, Spain
Soledad Penadés
1
Dept. Infectious Diseases &
Immunology, Utrecht University,
Utrecht, The Netherlands
Lonneke Vervelde
1
Nederlands Kanker Instituut (NKI),
Amsterdam, Nederland
Prof. Dr. F.E. van Leeuwen
1
NNF, Voorburg, Nederland
Dr. C. Hilders
1
Royal Hospital for Sick Children,
Edinburg, Scotland
Prof. Dr. W.H. Wallace
1
EKZ‐AMC, Amsterdam, Nederland
Dr. L.C.M. Kremer
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 177
Associate
van Egmond, M
van Furth, AM
van Grieken, NCT
van Hoogstraten, I
Collaborating institute
External collaborator(s)
Type of
collaboration*
UMCU/WKZ, Utrecht, Nederland
Drs. A.B. Versluijs
1
ErasmusMC/SKZ, Rotterdam, Nederland
Dr. M.M. van den Heuvel-Eibrink
1
UMCN, Nijmegen, Nederland
Dr. J.J. Loonen
1
LUMC, Leiden, Nederland
Dr. D. Bresters
1
UMCG, Groningen, Nederland
Dr. W. Tissing
1
Mainz University Medical Center, Mainz,
Duitsland
PanCareLIFE consortium
(PanCareLIFE project: EU-funded)
Dr. P. Kaatsch, Dr. J. Byrne, Dr.
M.M. van den Heuvel, Dr. L.C.M.
Kremer, Prof. T. Langer. Dr. G.
Calaminus, C. Clissman
3
St. Judes, Memphis, USA
Dr. L. Robison
3
University of Calgary, Calgary, Canada
Prof.dr. Paul Kubes
1
Inserm U699-Bichat Medical School,
Paris, France
Prof.dr. Renato Monteiro
1
University of Limoges, Limoges, France
Prof.dr. Michel Cogné
1
Tygerberg Hospital, Stellenbosch
University
Cape Town, South Africa
R.van Toorn, J Schoeman, G.
Walzl
1
Rijnland Ziekenhuis, Leiderdorp
M.E. Weijerman
1
Elisabeth Ziekenhuis, Tilburg
S. de Crom, CH. Obihara
1
Universiteit Maastricht, Maastricht
S.A.Morré
1
ANOVA institute, Mopani District, South
Africa
R. Peters
1
ESMID study group, Bern, Switserland
S. Leib
1
Universiteit Maastricht, Maastricht
P.Savelkoul
1
Centre for Human Metabolomics,
Potchefstroom, South Africa
S. Mason, R. Solomons, J.
Schoeman, R. Wevers. C.
Reinecke
1
Kilamanjaro Christian Medical Center,
Moshi, Tanzania
T. Msoka, J. Bartlett
1
Tijgerberg Hospital, Cape Town, South
Africa
S. van Elsland P. Springer, J.
Schoemans
1
University of Michigan Medical school,
Ann Arbor, MI, USA
M. El-Kebir, D. Kirschner
1
IPATIMUP, Porto, Portugal
Fatima Carneiro, Carla Oliveira,
Joanna Carvalho
1
Karolinkska universiteit, Stockholm,
Zweden
Pehr Lind
2
Århus Universitetshospital, Aarhus,
Denmark
Marianne Nordsmark
2
Leeds Institute of Molecular Medicine,
Leeds, United Kingdom
Phil Quirke, Heike Grabsch
1
ACTA, Amsterdam, Netherlands
Cees Kleverlaan
1
Faculty of Dentistry, Djember, Indonesia
Dessy Rachmawati
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 178
Associate
Collaborating institute
External collaborator(s)
van Kooyk, Y
University of Milan, Milan, Italy
Anna Bernardi
1
University of Helsinki, Helsinki, Finland
Kim Pettersson
1
Oxford University, Oxford, England
Ben Davis
1
CSCIC, Sevilla, Spain
Javier Rojo
1
van Litsenburg, RRL
Childhood Oncology Group,
Philadelphia, USA
Richard Aplenc
2
van Montfrans, C
Slotervaartziekenhuis, Amsterdam,
Nederland
drs. J. Serrarens
2
Centrum Oosterwal, Alkmaar, Nederland
drs. M.C. Mooij
2
Flevoziekenhuis, Almere, Nederland
drs. W. Roest
2
Sint Franciscus Gasthuis, Rotterdam,
Nederland
dr. M. Loots
2
Isala, Zwolle, Nederland
H. Lam, drs. G. Kuiters
2
Ziekenhuisgroep Twente, Hengelo,
Nederland
drs. C. Hebeda
2
Institute for Health Services Research in
Dermatology and Nursing; UMC
Hamburg, Hamburg, Germany
Prof. Dr. med. Matthias Augustin
4
Westfriesgasthuis, Hoorn, Nederland
S. Beukers
2
van Schaardenburg, D
University of Birmingham, Birmingham,
UK
Karim Raza
2
van Sörnsen de Koste, JR
London Regional Cancer Program,
Ontario, Canada
Dr D Palma
1
University of Maryland School of
Medicine, Baltimore, Canada
Prof W. D'Souza
1
Varian Medical Systems, Palo Alto, USA
H. Mostafavi
1
Velocity Medical Solutions, Atlanta, USA
Prof T. Fox
1
University of the West of England,
Bristol, UK
S hawlett, J Kirwan, C Flurey
1
Medical University of Vienna, Vienna,
Austria
J Smolen, T Stamm, M. Sadlanova
1
Centre for Translational Inflammation
Research, Birmingham, UK
K Raza, R Stack
1
Katholieke Universiteit Leuven, Leuven,
Belgie
P Verschueren
1
Pasteur Insitute, Paris, France
prof.dr. C. Leclerc, dr. S. Bay
1
University of Leicester, Leicester, UK
prof.dr. C. Pritchard
1
Emory University School of Medicine,
Atlanta, USA
prof.dr. R. Cummings
1
University of Georgia, Athens, USA
dr. D. Live
1
Case Western Reserve University School
of Medicine, Cleveland, USA
dr. B. Cobb
1
Great Ormond Street Hospital (GOSH)
and University College London Hospital
(UCLH), London, United Kingdom
Darren Hargrave
2
van Tuyl, L
Van Vliet, SJ
Veldhuijzen van Zanten, S
Type of
collaboration*
Appendix Annual Report 2013 VUmc CCA – International collaboration - 179
Associate
Verdonck-de Leeuw, IM
Collaborating institute
External collaborator(s)
Type of
collaboration*
Palliative care in DIPG, Vumc,
Netherlands
European DIPG network
1
Steroids in DIPG, Vumc, Netherlands
European DIPG network
1
Development of European DIPG registry,
Vumc, Netherlands
European DIPG network
1
European DIPG network, Vumc,
Netherlands
European DIPG network
3
Great Ormond Street Hospital (GOSH)
and University College London Hospital
(UCLH ), London, United Kingdom
Darren Hargrave
2
Palliative care in DIPG, Vumc,
Netherlands
European DIPG network
1
Steroids in DIPG, Vumc, Netherlands
European DIPG network
1
Development of European DIPG registry,
Vumc
Netherlands
European DIPG network
1
European DIPG network, Vumc,
Netherlands
European DIPG network
3
Oslo University Hospital, Oslo, Norway,
Oslo, Norway
EORTC Quality of Life Group,
Oral Health Module Development
Group. Hjermstad MJ, Bergenmar
M, Fisher SE, Montel S,
Nicolatou-Galitis O, RaberDurlacher J, Singer S, Verdonckde Leeuw IM, Weis J, Yarom N,
Herlofson BB
3
University of Mainz, Mainz, Germany
EORTC Quality of Life Group,
Head and Neck Cancer Module
Update Group. Singer S, Arraras
JI, Baumann I, Boehm A, Chie
WC, Galalae R, Langendijk JA,
Guntinas-Lichius O, Hammerlid
E, Pinto M, Nicolatou-Galitis O,
Schmalz C, Sen M, Sherman AC,
Spiegel K, Verdonck-de Leeuw
IM, Yarom N, Zotti P, Hofmeister
D
3
Bispebjerg Hospital, Copenhagen,
Denmark
EORTC Quality of Life Group,
Computerized Adaptive Testing
Group. Petersen MA, Aaronson
NK, Arraras JI, Chie WC, Conroy
T, Costantini A, Giesinger JM,
Holzner B, King MT, Singer S,
Velikova G, Verdonck-de Leeuw
IM, Young T, Groenvold M.
3
Innsbruck Medical University, Innsbruck,
Austria
EORTC Quality of Life Group,
electronic patient reported
outcome assessment. Holzner B,
Giesinger J, Groenvold M,
Petersen MA, Aaronson NK,
Velikova G, Verdonck-de Leeuw
IM
3
Twente University, Enschede,
Netherlands
KWF project. Bohlmeijer ET,
Drossaert S
1
University Medical Center Leiden,
Leiden, Netherlands
VerderZonderStembanden. Van
de Velden LA, Langeveld T,
2
Appendix Annual Report 2013 VUmc CCA – International collaboration - 180
Associate
Verweij, CL
Collaborating institute
External collaborator(s)
Type of
collaboration*
University Medical Center Maastricht,
Maastricht, Netherlands
VerderZonderStembanden. Van
de Velden LA, Langeveld T,
2
University Medical Center Groningen,
Groningen, Netherlands
NET-QUBIC (Netherlands Quality
of Life and Biomedical Cohort
Studies). Langendijk JA, Takes R,
Terhaard C,
1
Radboud University Medical Center,
Nijmegen, Netherlands
NET-QUBIC (Netherlands Quality
of Life and Biomedical Cohort
Studies). Langendijk JA, Takes R,
Terhaard C,
1
University Medical Center Utrecht,
Utrecht, Netherlands
NET-QUBIC (Netherlands Quality
of Life and Biomedical Cohort
Studies). Langendijk JA, Takes R,
Terhaard C,
1
VU University, Erasmus MC, Padjadjaran
University
Amsterdam, Rotterdam, Sumedang,
Netherlands, Indonesia
KWF project. Passchier J, de
Klerk, C, Sadarjoen SS
1
Tilburg University, Tilburg, Netherlands
CZ project Shared Decision
making in prostate cancer. De
Vries M, van Tol-Geerdink J, van
Uden-Kraan CF.
1
Vanderbilt, University School of
Medicine, Nashville, USA
Prof. Dr. Thomas Aune
1
University of Manitoba, Winnipeg,
Canada
Prof. Hani El-Gabalawy, PhD
1
University of Leeds, Leeds, Great Britain
Prof. Paul Emery, PhD, MD., Dr.
Frederique Pongel, PhD
1
Hospitaux Universiaires Paris-Sud
Universite Paris-Sud INSERM U1012,
Paris, France
Prof. Xavier Mariette, PhD, MD
1
University Hospital Umea, Umea,
Sweden
Prof. Dr. Solbritt RantapaaDahlvist
1
Stanford University, California, USA
Prof. Dr. William Robinson
1
Vis, AN
AMC, Amsterdam, The Netherlands
Waisfisz, Q and MeijersHeijboer, H
the Consortium of Investigators of
Modifiers of BRCA1/2 (CIMBA), multiple
broad international collaboration
the Breast Cancer Association
Consortium (BCAC), Multiple
broad international collaboration
Erasmus MC, Rotterdam, Netherlands
Martin vd Bent, Pim French,
Johan M. Kros, EORTC Brain
Tumor Group
2
Academic Medical Center, Amsterdam,
Netherlands
Eleonora Aronica
3
Academic Medical Center, Amsterdam,
Netherlands
Theo Hulsebos
1
UMC Utrecht, Utrecht, Netherlands
Paul van Diest
1
MD Anderson Cancer Center, Houston,
TX, USA
Ken Aldape
1
Heidelberg Univ. Hospital, Heidelberg,
Andreas von Deimling
1
Wesseling, P
3
Appendix Annual Report 2013 VUmc CCA – International collaboration - 181
Associate
Collaborating institute
External collaborator(s)
Type of
collaboration*
Germany
Harvard Univ./Mass. Gen. Hosp., Boston, Bakkhous Tannous
MA, USA
3
Munster Univ. Hosp., Munster, Germany
Martin Hasselblatt
1
Munchen Univ. Hosp., Munchen,
Germany
Jorg Tonn & EORTC Brain Tumor
Group
3
Heidelberg Univ. Hospital, Heidelberg,
Germany
Christel Herold-Mendes
3
University of St Andrews, St Andrews,
Scotland
Prof. Dr. David O'Hagan
1
ARRONAX, Nantes, France
dr J Barbet, dr C. Bourdeau
4
IAEA/IFIN-HH, ,Bucharest, Rumania
dr D Nicolae
4
Oxford University, Oxford, UK
Prof. Dr. Veronique Gouverneur
3
Wondergem, MJ
City of Hope, Los Angeles, USA
A. Krishnan
2
Yaqub, M
K0816 WP3AirforceNG, NL
1
WP3 IMI Klinisch, NL
1
WP4 Data analyse metholog. IMI, NL
1
Windhorst, AD
Ylstra, B
Zijlstra, JM
UMCN, Nijmegen, NL
Prof. dr H van Krieken, Prof. dr. I
Nagtegaal
3
NKI, Amsterdam, NL
Prof. dr. S Linn, dr. R Kerkhof,
dr. P Nederlof
3
AMC, Amsterdam, NL
Prof. dr. C. Punt
2
AMC, Amsterdam, NL
Prof. dr. R Versteeg, dr. J.
Molenaar
1
AMC, Amsterdam, NL
Prof. dr. F Baas, prof. Dr. E
Aronica
1
University of Paris, Paris, Fr
Prof. dr. A Idbaih
1
UCSF, San Francisco, USA
Profs. Dr D. Pinkel. D. Albertson,
H. Bengstton, A. Olshen
1
UCSF, San Francisco, USA
Prof. Dr. J Costello
1
Maastricht University, Maastricht, NL
Prof. Dr. E.J Speel, Prof. Dr. M.
Van Engeland
4
CNIO, Madrid, ES
Prof. dr. P Real
1
University of Edinburgh, Edinburgh, UK
Prof. dr. N. Gilbert
1
University of Cambridge, Cambridge, UK
Prof. dr. C. Caldas, Prof. dr. J
Brenton
1
University of Minho, Braga, PT
Prof. Dr. P Maciel
1
Royal College of Surgeons in Ireland,
Dublin, Ireland
Dr. A Byrne
3
Henri Mondor University Hospital,
Créteil, 94010, France
Michel Meignan, Corinne Haioun,
Andrea Gallamini,
3
St Thomas University, London, United
Kingdom
Sally Barrington, George
Mikhaeel
3
Appendix Annual Report 2013 VUmc CCA – International collaboration - 182
Associate
Collaborating institute
External collaborator(s)
University Hospital of Cologne,
Germany
Andreas Engert, Peter
Borchmann
3
HOVON Myeloma Working Group,
Rotterdam, Utrecht, Netherlands
Prof. dr. Pieter Sonneveld, Prof.
dr. Henk Lokhorst
2
HOVON Myeloma Working Group,
Rotterdam, Utrecht, Netherlands
Prof. dr. Pieter Sonneveld, Prof.
dr. Henk Lokhorst
1
European Myeloma Network, Turino,
Europe
See publications for whole list, in
particular Prof. dr. Antonio
Palumbo, prof. dr. Meletious
Dimopoulos, prof. dr. Jesus San
Miguel
2
Mayo Clinic, Scottsdale, USA
Prof. dr. Ruben Mesa
2
Associate
Collaborating institute
External collaborator(s)*
Ang, CW
Statens Serum Instit, Copenhagen,
Denmark
J Simonsen
3
Narodow Instytut Higieny, Warszawa,
Poland
M. Sadkowska-Todys
3
Institut de Veille Sanitaire, Saint-Maurice
cedex, France
H. de Valk
3
National public health institute,
Helsinki, Finland
M. Kuusi
3
Beelen RHJ
Zytoprotec, Vienna, Austria
advisory board
Bleeker, MCG
AvL/NKI, Amsterdam
CGOA (G. Kenter, M. van
Beurden)
1
Boellaard, R
Maastro, Maastricht, Netherlands
P. Lambin
3
IMI QuickConcept, International (IMI)
see website
3
Philips Healthcare, Cleveland,
Eindhoven, USA & Netherlands
Ling Shao, Piots Maniaswski
1
Philips Healthcare, Aachen, Germany
Volkmar Schulz
1
Roche, Zurich, Swiss
Gudrun Zahlman
1
Bontkes, H
CHDR, Leiden, Netherlands
Geert Jan Groeneveld
1
Brakenhoff, RH
InteRNA Technologies BV, Utrecht,
Netherlands
Dr R Schaapveld, KP7 MiRacle
3
Quiet Therapeutics, Tel Aviv, Israel
R Lahav, KP7 MiRacle
3
Carvalho, B
Exact Sciences, Madison, Wisconsin, US
Dr. Barry Berger, Dr. Graham P.
Lidgard
3
Cloos, J
Onyx Pharmaceuticals, South San
Francisco, USA
C.J. Kirk
1
Discovery, Millennium Pharmaceuticals,
Inc. , Cambridge, USA
L. Dick
1
Zweegman, S
Type of
collaboration*
Non academic
Type of
collaboration*
Appendix Annual Report 2013 VUmc CCA – International collaboration - 183
Associate
Collaborating institute
External collaborator(s)*
N8Medical, Columbus, Ohio, USA
C. Genberg
1
Pfizer, San Diego CA, USA
Dr Karin Jooss
1
Cell Genesys Inc, S San Francisco CA,
USA
Dr Kristen Hege, Dr Natalie
Sacks, Dr Karin Jooss, Dr
Thomas Harding
1
DCPrime BV, Leiden, NL
Dr Sandra van Wetering, Prof dr
Ada Kruisbeek
1
NIBR, Basel, Switzerland
Patel et al.
3
Lilly, London, UK
Brail L
4
Fijneman, RJA
Erasmus MC, The Hyve, Genalice,
Philips, Rotterdam, Utrecht, Harderwijk,
Eindhoven, Nederland
CTMM TraIT (Center for
Translational Molecular Medicine
- Translational research IT - Work
Package 4) Guido Jenster, Kees
van Bochove, Henk Obbink, Wim
van der Linden
3
Gibbs, S
CellSystems GmbH, Troisdorf, Germany
Dr Horst Fuchs
3
MB Research Labs,; Spinnerstown, PA,
USA
George DeGeorge
3
MatTek Corporation, Ashland, MA, USA
Patrick Hayden
3
3Rs Management and Consultancy,
Bagsvaerd, Denmark
Erwin Roggen
3
A-Skin, Amsterdam, Netherland
prof RJ Schepper
1
Hoekstra, OS
Philips Healthcare, Cleveland, USA
P Maniawski
1
Huisman, M
Philips Healthcare, PECT-CT exhibits (3),
Cleveland, USA
Antonis Kalemis
1
Hulleman, E
to BBB, Leiden, The Netherlands
Pieter Gaillard
1
Janssen, JJWM
Dept of Hematology, Dordrecht, NL
Dr. P. Westerweel
2
Dept of Hematology, Delft, NL
Dr. E. Posthuma
2
Dept of Hematology, Enschede, NL
Dr. W. Smit
2
Dept of Hematology, Zwolle, NL
Dr. M. van Marwijk Kooij
2
Dept of Hematology, Den Haag, NL
Drs. P. Ypma
2
Shire-Movetis NV, Turnhout, Belgium
Dr. J.A.J. Schuurkes
1
Center for Human Drug Research,
Leiden, Netherlands
Prof. dr. A. Cohen
1
Bayer HealthCare AG, Berlin, Germany
Dr. A. Hoffmann
1
Department of Nutrition and Dietetics,
Royal Brisbane & Women’s Hospital,
Brisbane, Australia
T. Brown T
1
Department of Nutrition and Dietetic
Services, Princess Alexandra Hospital,
Brisbane, Australia
Davidson WL
1
Centre International de recherche sur le
cancer (IARC), Lyon, France
Silvia Franceschi, Gary Clifford,
Hugo de Vuyst, Massimo
Tomassino, Iaccopo Bausano
3
Institut Catala d'Oncologia (ICO),
Barcelona, Spain
Cancer Epidemiology Research
Program (CERP): Xavier Bosch,
3
de Gruijl, TD
de Rie, MA
Lammertsma, AA
Langius, JAE
Meijer, CJLM
Type of
collaboration*
Appendix Annual Report 2013 VUmc CCA – International collaboration - 184
Associate
Collaborating institute
External collaborator(s)*
Type of
collaboration*
Silvia de SanJose, Xavier
Castellsague
Scientific Institute of Public Health,
Brussels, Belgium
Marc Arbyn
3
CHU Reims, Laboratoire Pol Bouin,
Reims, France
Christine Clavell, Véronique
Dalstein
3
Department of OBGYN &, Wolfsburg,
Germany
Ulli Petry
3
DDL, Rijswijk, Netherlands,
Wim Quint
3
GGD Amsterdam, Amsterdam,
Netherlands
Maarten Schim van het Loef
1
Meijer, GA
TranSMART
M. Braxenthaler
Moll, A
NKI, Amsterdam, The Netherlands
Flora E. van Leeuwen
1
Neefjes, ECW
Amstelland Ziekenhuis, Amstelveen,
Netherlands
Cees v Groeningen
2
Hospice Bardo, Hoofddorp, Netherlands
Manon Boddaert
2
Hospice Kuria, Amsterdam, Netherlands
Wouter Zuurmond
2
Medisch Centrum Alkmaar, Alkmaar,
Netherlands
Suzan Vrijaldenhoven
2
Medisch Spectrum Twente, Enschede,
Netherlands
Machtold Wymenga
2
Spaarneziekenhuis, Hoofddorp,
Netherlands
Aart Beeker
2
Tergooi Ziekenhuizen, Hilversum,
Netherlands
Pieter vd Berg
2
Noordhuis, P
Peters, GJ
ImmunoGen, Waltham, United States
1
Amgen, United States
1
Eli Lilly &CO, European Head Quarters,
Germany
Dr. A. Hanauske
1
Pharmamar, Madrid, Spain
Dr. C.M. Galmarini
1
Clavis Pharma, Oslo, Norway
Dr. M. Sandvold
1
Reijneveld, JC
EORTC Quality of Life Group, Active
member, Belgium
Bottomley, A., Coens C.,
1
Sminia, S
EBG MedAustron Particle Therapy Center
Wiener Neustadt, Austria
Prof. dr. R. Mayer
4
Snijders, PJF
Centre International de recherche sur le
cancer (IARC), Lyon, France
Silvia Franceschi, Gary Clifford,
Hugo de Vuyst, Massimo
Tomassino
3
Institut Catala d'Oncologia (ICO)
Barcelona, Spain
Cancer Epidemiology Research
Program (CERP): Xavier Bosch,
Silvia de SanJose, Xavier
Castellsague
3
Scientific Institute of Public Health,
Brussels, Belgium
Marc Arbyn
3
Crucell, Leiden, Netherlands
Gert Scheper
1
Appendix Annual Report 2013 VUmc CCA – International collaboration - 185
Associate
Collaborating institute
External collaborator(s)*
Type of
collaboration*
DDL, Rijswijk, Netherlands
Wim Quint
3
GGD Amsterdam, Amsterdam,
Netherlands
Maarten Schim van het Loef
1
Steenbergen, R
Crucell, Leiden, Netherlands
G Scheper
1
van Grieken, NCT
Avl / NKI, Amsterdam, the Netherlands
Annemieke Cats, Marcel Verheij,
Edwin Jansen, Henk Boot,
Johanna van Sandick
2
van Kooyk, Y
TWINCORE, Hannover, Germany
Tim Sparwasser
1
van Schaardenburg, D
NIVEL, Utrecht, NL
M Nielen, J Ursum, F Schellevis
1
Verbakel, WFAR
Varian Medical Systems, Helsinki,
Finland
Knowledge Based Planning
Council. Duk University: Jacky
Wu, Washington State University:
Sasha Mutic, IOSI Bellinzona:
Luca Cozi
4
Yaqub, M
Philips Healthcare, clinical exhibits,
Cleveland, USA
Antonis Kalemis
1
Philips Healthcare, Exhibit PETMR
physics VU-01, Cleveland, USA
Ling Shao, Hans Hofstraat and
Volkmar Schulz
1
Ylstra, B
Cergentis, Utrecht, NL
Dr. M van Min
1
Zijlstra, JM
NIVEL, Utrecht, Netherlands
Sandra van Dulmen
4
Appendix Annual Report 2013 VUmc CCA – International collaboration - 186
Appendix 9. Scientific Research Committee
CWO: Clinical protocols
Indiener
Titel
Adank MA
Hereditary breast cancer and the clinical significance of variants in the BRCA1
an BRCA2 genes
Ankersmit M
Sentinel lymph node identification in colon cancer using a radioactive and
fluorescent tracer; a feasibility study
Blauwhoff-Buskermolen S
The effect of individualized NUTritional counselling on muscle mass and
treatment outcome in patients with metastatic COLOrectal cancer undergoing
chemotherapy: the COLONUT study
Boven E
PI3K pathway analysis in tumor tissue and circulating DNA to obtain further
insight in the efficacy of everolimus when combined with exemestane
Boven E
A randomized phase II trial of pertuzumab in combination with trastuzumab
with or without chemotherapy, both followed by T-DM1 in case of progression,
in patients with HER2-positive metastatic breast cancer
Bruynzeel AME
A Randomized Trial of Dose Escalation in definitive Chemoradiotherapy for
patients with Oesophageal cancer - ART DECO study'
Bruynzeel AME
Randomized Multicentre Phase III study of short course radiation therapy
followed by prolonged pre-operative chemotherapy and surgery in primary high
risk rectal cancer compared to standard chemoradiotherapy and surgery and
optional adjuvant chemotherapy
Buffart L
How many exercise reduce fatigue in patients with cancer? A pilot study
examining the role of muscular, immune and endorcrine systems
Chamuleau M
A phase Ib study evaluating the safety, pharmacokinetics, pharmacodynamics,
and clinical activitiy of GS-9820 monotherapy and combination therapy in
subjects with lymphoid malignancies (GS-US-315-0102)
Chamuleau MED
HOVON 121 CLLM1/GCLLSG studie A phase 3, multicenter, randomized,
double-blind, placebo-controlled, parallel-group study of the efficacy and safety
of lenalidomide (Revlimid®) as maintenance therapy for high-risk patients with
chronic lymphocytic leukemia following first-line therapy
de Bree R
PREDICTION study: The predective value of PET-CT and PET-DW-MRI early
during chemoradiotherapy for locoregional control of advanced stage head and
neck cancer'
de Meij TG
The HIPI study: hypnotherapy for adolescents and adults with inflammatory
bowel disease and symptoms compatible with irritable bowel syndrome; a
multi-center randomized controlled trial
de Witt Hamer PC
Accurate delineation of glioma infiltration by advanced PET/MR neuro-imaging
Dirven L
Development of a new questionnaire to measure instrumental activities of daily
living (I-ADL) in patients with primary brain tumors
Forouzanfar T
Endoscopic treatment of salivary glands affected by Sjögren Syndrome; A
randomized controlled pilot study
Haarman EG
Hypertonic saline in primary ciliary dyskinesia: a pilot study'
Hoekstra OS
A study on the pharmacokinetics of [18F]-fluordihydrotestosterone in patients
with metastasized castrate resistant prostate cancer
Janssen JJWM
Protocol CAMN107I2201 (ENEST Freedom): A single-arm, multicenter, nilotinib
treatment-free remission study in patients with BCR-ABL1 Positive Chronic
Myelogenous Leukemia in chronic phase who have achieved durable minimal
residual disease (MRD) status on first line nilotinib treatment
Janssen JJWM
CAMN107A2408: A phase II, single arm, open label study of treatment-free
remission after achieving sustained MR4.5 on nilotinib
Kaspers GJL
30-day, open-label, active-controlled, randomized study of the safety, efficacy
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 187
Indiener
Titel
and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban
in children with various manifestations of venous thrombosis
Koekkoek JAF
Withdrawal of antiepileptic drugs in low grade and anaplastic glioma patients
after long-term seizure freedom
Menke CW
89Zr-MMOT0530A PET imaging in patients with unresectable pancreatic of
platinum-resistant ovarian cancer before treatment with DMOT4039A
Nielsen K
Pilot study: The use of PET-MRI in the follow-up of RFA and MWA treated
colorectal liver metastases'
Oostlander A
Studying lymph nodes in Rheumatoid Arthritis: B cell trafficking'
Ossenkoppele GJ
A phase II multi-center, open label, randomized study to assess safety and
efficacy of two different schedules of oral LDE225 in adult patients with
relapsed/refactory or untreated elderly patients with acute leukemia
Ossenkoppele GJ
Protocol B1871040: An Open-label Bosutinib Treatment Extension Study for
Subjects with Chronic Myeloid Leukemia (CML) Who Have Previously
Participated in Bosutinib Studies B1871006 or B1871008
Ossenkoppele GJ
A phase I, multicenter, open-label study of oral LGH447 in patients with acute
myeloid leukemia or high risk myelodysplastic syndrome
Ossenkoppele GJ
CABL0012101 protocol: a phase I, multicenter, open-label study of oral ABL001
in patient with chronic myelogenous leukemia of Philadelphia Chromosomepositive acute lymphoblastic leukemia
Platek EE
A phase 3, multicenter, randomized, double-blind placebo-controlled study to
assess the efficacy and safety of Tocilizumab in subjects with Giant Cell
Arteritis
Rasch L
Treat-to-target strategy for early RA patients in usual clinical practice: The
COBRA Cohort Study
Scheffer HJ
Pilot study: Non-thermalablation using Irreversible Electroporation (IRE) to treat
locally advanced pancreatic carcinoma - a phase I clinical trial'
Smit EF
A multicenter, open-label, randomized phase II study to evaluate the efficacy of
AUY922 vs pemetrexed or docetaxel in NSCLC patients with EGFR mutations
who have progressed on prior EGFR TKI'
Smit EF
A phase II study of the selective BRAF kinase inhibitor GSK2118436 in subjects
with advanced non-small cell lung cancer and BRAF mutations'
Smit EF
A Single-Arm, Multicenter, Open-Label, Phase 2 Study of Gemcitabine-Cisplatin
Chemotherapy Plus Necitumumab (IMC-11F8) in the First-Line Treatment of
Patients With Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC)
Smit EF
A Phase II, multicenter, single-arm study of oral LDK378 in adult patients with
ALK-activated non-small cell lung cancer previously treated with chemotherapy
and crizotinib
Smit EF
A Randomized open label Phase 2 study evaluating LY2875358 plus Erlotinib
and LY2875358 monotherapy in MET diagnostic possitive NSCLC patients with
aquired resistance to Erlotinib
Smit EF
A Phase III multicenter, randomized study of oral LDK378 versus standard
chemotherapy in previously untreated adult patients with ALK rearranged (ALKpossitive), stage IIIB or IV, non-squamous non-small cell lung cancer (2301)
Smit EF
A phase III Double-Blind, Randomised, Placebo-Controlled Study to Assess the
Efficacy and Safety of Selumetinib (AZD6244, ARRY-142886) (Hyd-Sulfate) in
Combination with Docetaxel, in Patients receiving second line treatment for
KRAS Mutation-Possitive Locally Advanced or Metastatic Non Small Cell Lung
Cancer (Stage IIIB-IV) (D1532C00079)
Smit EF
Determination of peripheral immune cell activity during treatment with either
surgery or radiotherapy in patients with early stage non-small cell lung cancer
Smit EF
A phase III multicenter, randomized, open-label study of oral LDK378 versus
standard chemotherapy in adult patients with ALK rearranged (ALK-possitive),
advanced non small cell lung cancer who have been treated previously with
chemotherapy (platinum doublet) and crizotinib (CLDK 2303)Determination of
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 188
Indiener
Titel
peripheral immune cell activity during treatment with either surgery or
radiotherapy in patients with early stage non-small cell lung cancer
Thunnissen E
Non Small Cell Lung Cancer (NSCLC) ALK IHC positive study
Uyl- de Groot CA
Patient Reported Outcomes in the Castration-resistant Prostate cancer RegIstry:
PRO-CAPRI
van Bodegraven AA
A Double-Blind, Randomized, Placebo-Controlled, Parallel, Dose-Ranging Study
to Evaluate the Efficacy and Safety of PF-00547659 in Patients with Moderate to
Severe Ulcerative Colitis (TURANDOT)
van Bodegraven AA
A Multicenter Open-Label Extension Study To Assess Long-Term Safety of PF00547659 in Subjects With Ulcerative Colitis (TURANDOT II)
van Bodegraven AA
A 52 week Randomised, Double-blind, Placebo-controlled Study to Investigate
the Efficacy and Safety of GSK1605786A in the Maintenance of Remission in
Subjects with Crohn's Disease (CCX114157 studie)
van Bodegraven AA
A Randomised, Double-blind, Active Treatment Study to Induce Clinical
Response and/or Remission with GSK1605786A in Subjects with Moderately-toSeverely Active Crohn's Disease (CCX114643 studie)
van Bodegraven AA
An Open-Label Extension Study of CP-690,550 as Maintenance Therapy In
Patients With Crohn''s Disease
van Dam EWCM
Differentiated thyroid carcinoma in children: Late effects of treatment and
pathophysiological background in the Netherlands (ABR NL40572.042.12)
van den Eertwegh AJM
Randomized, phase II study of MK-3475 versus chemotherapy in patients with
advanced melanoma'
van den Eertwegh AJM
A phase 1 Study to Evaluate the Safety, Tolerability and Efficacy of MK-8353
Combination Therapies in Subjects With Advanced Solid Tumors'
van den Eertwegh AJM
A phase III, randomise, open-label study comparing the combination of the
BRAF inhibitor, GSK2118436 and the MEK inhibitor, GSK1120212 to the BRAF
inhibitor vemurafenib in subjects with advanced (stage IIIc) or metastatic (stage
IV) BRAF V600E/K mutation positive melanoma'
van den Eertwegh AJM
COMBI-AD: A phase III randomized double blind study of dabrafenib
(GSK2118436) in COMBInation with trametinib (GSK1120212) versus two
placebos in the Ajjuvant treatment of high-risk BRAF V600 mutation-positive
melanoma after surgical resection (BRF115532
van den Eertwegh AJM
Radium-223 Chloride (A;pharadin) in Castration-Resistant (Hormone-Refractory)
Prostate Cancer Patients with Bone Metastasis'
van den Eertwegh AJM
COLUMBUS - Combined LGX818 Used with MEK162 in BRAF mutant
Unresectable Skin cancer
van Goudoever JB
NOPHO-DBH AML 2012 Protocol, Research study for treatment of children and
adolescents with acute myeloid leukemia 0 - 18 years
van Goudoever JB
Intergroup trial for children or adolescents with B-cell NHL or B-AL: evaluation
of Rituximab efficacy and safety in high risk patients
Abbreviated name: Inter-B-NHL ritux 2010
van Linde ME
A double-blind, placebo-controlled, randomized, phase IIIb trial evaluating the
efficacy and safety of standard of care (SOC) +/-continuous bevacizumab
treatment following progression of disease (PD) in patients with glioblastoma
(GBM) after first (1st)-line treatment with radiotherapy, temozolomide and
bevacizumab'
van Linde ME
EORTC protocol 26101: phase III trial exploring the combination of
bevacizumab and lomustine in patient with first recurrence of a glioblastoma
van Montfrans C
A Randomized, double-blinded, regimen-controlled, phase II, multicenter study
to assess the efficacy and safety of two different vismodegib regimens in
patients with multiple basal cell carcinomas
van Moorselaar RJA
212082PCR3011: A randomised, Double-blind, comparitive study of
(abiraterone Acetate) Plus Low-dose Prednisone Plus Androgen Deprivation
Therapy (ADT) Versus ADT Alone in Newly Diagnosed Subjects With High Risk,
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 189
Indiener
Titel
Metastatic Hormone-naive Prostate Cancer (mHNPC)'
van Moorselaar RJA
A prospective, randomized study about the effect on overall survival of
hormonal therapy versus hormonal therapy combined with external radiation
therapy in patients with M+ prostate cancer'
van Nieuwkerk CMJ
A Phase III, Randomised, Partially Double-Blind and Placebo-Controlled Study of
BI 207127 in Combination with Faldaprevir and Ribavirin in Treatment-Naïve
Patients with Chronic Genotype 1 HCV Infection'
Veening MA
Double blind randomized intervention study aiming at reducing
dexamethasone related side effects in children with acute lymphoblastic
leukemia (ALL). (Dexadagen studie)
Verdonck IM
Netherlands Quality of Life and Biomedical Cohort Studies In Cancer_Head and
Neck Cancer (NET-QUBIC_HNC)
Verheul HMW
The role of surgery of the primary tumour with few or -absent symptoms in
patients with synchoronous unresectable metastases of colon cancer, a
randomized phase III study'
Verheul HMW
Image guided treatment optimalization with cetuximab for patients with
metastatic colorectal cancer: IMPACT-CRC
Verheul HMW
Pilot study on the determination of tumor concentrations of protein kinase
inhibitors in patients with newly diagnosed high-grade glioma
Verheul HMW
A phase I open-label clinical trial, evaluating the therapeutic vaccine hVEGFtrunc/PEP-A10 in patients with advanced solid tumors
Verheul HMW
Pilot study to determine the effect of fractioned radiotherapy on expression of
pro-angiogenic factors in oesophagus carcinoma
Verheul HMW
A Two-part, Randomised, Open-label, Multicentre, Phase I Study to Determine
the Effect of Food on the Pharmacokinetics of Olaparib Following Single 400
mg Doses of the Capsule Formation in Patients with Advanced Solid Tumours
Verheul HMW
A phase I study of SGI-110 combined with irinotecan followed by a randomized
phase II study of SGI-110 combined with irinotecan versus regorafenib in
previously treated metastatic colorectal cancer patients
Verheul HMW
A Non-randomised, Open-label, Wequentail, Three-part, Phase I Study to Assess
the Effect of Itraconazole (a CYP3A4) Inhibitor) on the Pharmacokinetics of
Olaparib Following Oral Dosing of a Tablet Formulation, and to Provide Data on
the Effect of Olaparib on QT Interval Following Oral Dosing of a Tablet
Formulation to Patients with Advanced Solid Tumours
Verheul HMW
An open-label, multi-center, dose-escalation Phase I study with an expansion
phase, to evaluate safety, pharmacokinetics and therapeutic activity of
RO6895882, an immunocytokine, consisting of a variant of Interleukin-2 (IL-2v)
targeting carcinoembryonic antigen (CEA), administered intravenously, in
patients with advanced and/or metastatic solid tumors
Verheul HMW
A multi-institutional open label, trial evaluating the efficacy of Gemcitabine and
Docetaxel in patients with relapsed or refractory metastatic colorectal
adenocarcinoma with methylated CHFR and/or microsatellite instability
phenotype
Verheul HMW
An International, Randomized, Double-Blind, Controlled Study of
Rindopepimut/GM-CSF with Adjuvant Temozolomide in Patients with Newly
Diagnosed, Surgically Resected, EGFRvIII-Positive Glioblastoma (The ACT IV
Study)
Verheul HMW
An Open-label, Non-randomised, Multicentre, Comparative, Phase I study of the
Pharmacokinetics, Safety and Tolerability of Olaparib following a single oral
300 mg dose to patients with Advanced Solid Tumours and Normal Renal
Function or Renal Impairment
Verheul HMW
An Open-label, Non-randomised, Multicentre, Comparative, Phase I study to
determine the Pharmacokinetics, Safety and Tolerability of laparib following a
single oral 300 mg dose to patients with Advanced Solid Tumours and Normal
Hepatic Function or Mild or Moderate Hepatic Impairment
Verheul HMW
A non-randomised, open-label, sequential, multicentre, two part, phase I study
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 190
Indiener
Titel
to assess the effect of rifampicin, a cyp inducer, on the pharmacokinetics of
olaparib following oral dosing of a tablet formulation in patients with advanced
solid tumours
Versteeg KS
Optimalization of systemic treatment strategies in elderly patients with
advanced solid malignancies'
Visser OJ
Physical exercise to improve fitness and combat fatigue in patients with
Multiple Myeloma or (non-) Hodgkin's Lymphoma after high dose chemotherapy
and autologous stem cell transplantation
Visser OJ
R-FACT study: Risk factors for alloimmunization after erythrocyte transfusion: a
transfusion case control study
Visser OJ
A Randomized Phase 3 Study of BEAM vs. 90-Yttrium Ibritumomab Tiuxetan
(Zevalin®/BEAM in Patients Requiring Autologous Hematopoietic Stem Cell
Transplantation (ASCT) for Relapsed Diffuse Large B-cell Non-Hodgkin
Lymphoma (DLBCL)
Wilhelm AJ
TRough vs AUC Monitoring of cyclosporine: A randomized comparison of
adverse drug reactions in allogeneic stem cell recipients (TRAM-study)
Zijlstra JM
MITRAL study: Advanced PET and MRI techniques for improved therapy
response assessment in diffuse large B-cell lymphoma
Zijlstra JM
SPI-ZEV-11-301 (HOVON 120): A Phase 3, Open-label, Multicenter, Randomized
Study of Sequential Zevalin (ibritumomab tiuxetan) versus Oberservation in
Patients at Least 60 years of Age with Newly Diagnosed Diffuse Large B-cell
Lymphoma in PET-negative Complete Remission After R-CHOP or R-CHOP-like
Therapy
Zweegman S
A Phase 3, Randomized, Double-Blind, Multicenter Study Comparing Oral
MLN9708 Plus Lenalidomide and Dexamethasone Versus Placebo Plus
Lenalidomide and Dexamethasone in Adult Patients With Relapsed and/or
Refractory Multiple Myeloma
Zweegman S
Daratumumab (HuMax-CD38) safety study in multiple myeloma - Open label,
dose-escalation followed by open-label, single-arm study
Zweegman S
A Phase Ib/II, open-label, multi-center, dose-finding study to assess the safety
and efficacy of the oral combination of LDE225 and INC424 (Ruxolitinib) in
patients with myelofibrosis
Zweegman S
HOVON 123 MM: Feasibility and Effecacy of dose adjusted Melphalan Prednisone - Bortezomib (MPV) in elderly patients > 75 years of age with newly
diagnosed Multiple Myeloma; a non-randomised phase II study
Zweegman S
A Multicenter, Single-arm, Open-label Study with Pomalidomide in Combination
with Low Dose Dexamethasone in Subjects with Refractory or Relapsed and
Refractory Multiple Myeloma
CWO Research project / grant proposals
Grant
Principal investigator
Title
CCA
Appelmelk B
A tale of TRAIL
CCA
Bakema J
The more the merrier: Combining the strengths of IgG
monoclonal antibodies (mAbs) and FcaRI targeting to improve
anti-CD20 therapy of B cell malignancies.
CCA
Bontkes H
Peripheral blood leucocyte flowscore as biomarker for prediction
of prognosis and treatment outcome of late stage colorectal
cancer
CCA
Bosch L
Decoy Receptor 1 (DCR1), apoptosis and drug response
CCA
Braakhuis B
Intra-tumor genetic heterogeneity as a determinant of failure
after chemoradiation for head and neck squamous cell
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 191
Grant
Principal investigator
Title
carcinoma
CCA
Brakenhoff R
Biochemical development and analysis of novel WEE1 kinase
inhibitors for the treatment of head and neck cancer and brain
tumors
CCA
Carvalho B
Colorectal adenoma to carcinoma progression; the role of
AURKA and TPX2
CCA
Castelijns J
The predictive value of PET-MRI (especially with optimalization
of perfusion MRI) during the early phase of primary
chemoradiotherapy in advanced stages of head and neck cancer
for tumor recurrence
CCA
Cillessen S
Expression of Noxa as prediction marker for development of
Enteropathy associated T-cell lymphoma.
CCA
Cloos J
Splicing alterations as novel mechanism of drug resistance
CCA
Coupe V
A colorectal cancer model including molecular features:
prediction of health benefits and economic outcomes of new
generation screening tests and assessment of a molecular-based
intermediate endpoint
CCA
de Boer N
Sniffing cancer: the detection of adenoma and carcinoma of the
colon by volatile organic compounds analysis
CCA
de Gruijl T
Therapeutic interference in the immunosuppressed tumor
microenvironment: development of a fully human and immunecompetent melanoma-in-skin equivalent model
CCA
de Langen J
Endoscopic Optical Frequency Domain Imaging in Lung Cancer
CCA
de Vries E /
Peerdeman S
Peritumoral edema in patients with meningioma. What causes
the BBB to leak?
CCA
de Winter J
FANCM-deficiency in sporadic tumors: novel opportunities for
cancer therapy?
CCA
de Wit M
Identification and validation of colorectal cancer protein
biomarkers for disease monitoring and treatment response
prediction in blood
CCA
den Haan J
Vaccination strategies to activate all effector arms of the
adaptive immune system for the treatment of metastatic
colorectal cancer.
CCA
Dorsman J
A novel approach to antioxidant cancer research
CCA
Fijneman R
The role of RUNX1 in cancer (stem) cell biology
CCA
Garcia Vallejo J
Turning tumor glycans into anti-cancer vaccines
CCA
Greijer A
Explore lethal induction of Epstein Barr virus as new targeted
therapy for patients with gastric carcinoma
CCA
Griffioen A
Design of an effective anti-angiogenic combination therapy for
renal cell cancer using a stochastic algorithm
CCA
Gul N
Colorectal cancer surgery: a Trojan horse for liver metastasis
development?
CCA
Hendrikse H
[18F]afatinib PET in NSCLC to identify who will benefit from
afatinib
CCA
Jimenez C
Targeted mass spectrometry-based kinome activity assay to
enable personalized medicine
CCA
Koppers-Lalic D
Decoding the exosome message: a next-generation sequencing
and tailored bioinformatics for non-coding RNA biomarkers
CCA
Kwakman R / Meijer G
Tailoring intra-peritoneal cytostatic treatment during HIPEC
CCA
Langius J
Feasibility of a combined nutritional and home-based physical
exercise program during chemo(radio)therapy in patients with
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 192
Grant
Principal investigator
Title
non-small cell lung cancer
CCA
Noordhuis P
Identification and characterization of the ligand for the novel Ctype Lectin-Like receptor CLEC12A and impact for targeted
therapy of Acute Myeloid Leukemia
CCA
Peerdeman S /
Hulleman E
Characterization of pediatric meningiomas; a first step to a
stratified treatment approach
CCA
Pegtel M
Tumor Microvesicles for non-invasive remission monitoring
CCA
Pham T
Software pipeline for external validation of CCA OMICs datasets
CCA
Smit E
New strategies for treatment of EGFR-TKI resistant NSCLC:
unravelling the role of TGF-b signalling from bench to the
bedside
CCA
Smit L
Development of a molecular diagnostic platform for detection of
clinically significant gene mutations and translocations in
leukemia by targeted next generation sequencing
CCA
Snellenberg S
PRDM14, a novel apoptosis modulator in cervical cancer
CCA
van Beusechem V
Development of novel cancer drugs directed against G-protein
coupled receptors to improve treatment of prostate, lung and
brain tumors
CCA
van Dellen E
Staging brain tumors: a complex networks perspective
CCA
van der Vliet J
Targeting of CD1d in multiple myeloma
CCA
Versteeg K
Development of a new diagnostic test to predict for systemic
treatment toxicities in elderly patients with advanced solid
malignancies
CCA
Vis A
Linking cholesterol and testosterone metabolism to PCa
oncogenesis and disease progression
CCA
Wurdinger T
Sensitization of glioblastoma to TMZ by clinically available ySecretase inhibitors (GSIs)
CCA
Wurdinger T
Platelet-based RNA diagnostics for monitoring targeted therapy
of NSCLC and melanoma
ERC
Snijders PJF
MASS-CARE: molecular self screening for cervical cancer
prevention
KWF
Ankersmit M
Immunophotodetection in colorectal cancer using an Anti-CEA
MAb-IRDye800CW tracer
KWF
Bijnsdorp IV
Development of a novel diagnostic test for non-invasive follow
up on bladder cancer
KWF
Braakhuis BJM
Expression signature in peripheral blood cells for molecular
diagnosis of head and neck squamous cell carcinoma
KWF
Brakenhoff RH
Identification of druggable radiosensitizing genes by functional
genetic screens in HPV-positive head and neck cancer cell lines
KWF
Brakenhoff RH
Disrupted FA pathway of genomic maintenance as a marker for
chemoradiotherapy in head and neck cancer
KWF
Carvalho B
Signaling pathways involved in colorectal adenoma-to-carcinoma
progression
KWF
de Winter JP
FANCM-deficiency in sporadic tumors: novel opportunities for
cancer therapy?
KWF
de Witt Hamer PC
Phase 0 clinical studies in the drug development pipeline for
glioblastoma: WEE1 kinase
inhibition using oral MK1775
KWF
Douw L
Multi-scale brain networks in glioma: bridging the gap between
molecular markers and clinical status
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 193
Grant
Principal investigator
Title
KWF
Eersels JLH
Radioiodinated α-vinyl amino acids as Theranostic Agents for
glioma
KWF
Giovannetti E
Clinical outcome prediction in non-small cell lung cancer
(NSCLC) patients treated with novel
irreversible epidermal growth factor receptor (EGFR) tyrosine
kinase inhibitors (TKI)
KWF
Griffioen AW
Delineation of the embryonic transcriptome to identify novel
targets in the tumor endothelium; design of an angiostatic
vaccine for the treatment of cancer
KWF
Heideman DAM
The use of oncogenic sequence alterations for early detection of
lung cancer
KWF
Hulleman E
Convection Enhanced Delivery for Diffuse Intrinsic Pontine
Glioma (DIPG):
conventional drugs for novel treatment
KWF
Jimenez CR
Discovery and clinical validation of novel protein biomarkers for
response
prediction to cisplatin-based treatment regimens in non-small
cell lung cancer
KWF
Koning JJ
The role of bone marrow stromal cells as the driving force of
disturbed differentiation of dendritic cell subsets in MDS
KWF
Le Large M
MicroRNAs as novel diagnostic and prognostic factors in
pancreatic cancer
KWF
Moll AC
Second primary malignancies in hereditary retinoblastoma
patients. Who gets it and what type?
KWF
Pegtel DM
Urine microvesicle-diagnostics to identify prostate cancer
KWF
Scheffer HJ
COLDFIRE-2: Colorectal liver metastatic disease and efficacy of
irreversible electroporation
KWF
Schuurhuis GJ
Identification of therapy surviving leukemia initiating cells in
acute myeloid
leukemia
KWF
Slee-Valentijn M
Multicenter randomized controlled trial of a geriatric liaison
intervention in oncology versus usual care in older patients with
advanced colorectal cancer (CRC)
KWF
Smit L
Elucidating the TGFb signalling pathway as a therapeutic target
for the worst prognostic acute myeloid leukemia subtype, EVI-1
positive AML
KWF
Smit L
Therapeutic targeting of drug resistant acute myeloid leukemia
stem cells
KWF
Snellenberg S
Methylation-mediated silencing of PRDM14 contributes to
apoptosis evasion in
HPV-induced transformation and represents a promising disease
marker for cervical cancer
KWF
Steenbergen RDM
HPV-type dependent capacities and mechanisms of
transformation
KWF
Steenbergen RDM
Development of a methylation marker panel for the detection of
progressive, highgrade anal intraepithelial neoplasia and anal
cancer in HIV+ men
KWF
Straatman JE
STOMACH trial:
Surgical Technique; Open versus Minimally invasive gastrectomy
After Chemotherapy
KWF
van Beusechem VW
Mechanism of resistance to receptor tyrosine kinase inhibitors:
possible starting-points for
personalized cancer therapy
KWF
van der Vliet JJ
Exploiting Vγ9Vδ2-T cells for the treatment of HER2overexpressing gastroesophageal
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 194
Grant
Principal investigator
Title
cancer
KWF
van der Vliet JJ
Exploiting Vγ9Vδ2-T cells for the treatment of HER2overexpressing gastroesophageal
cancer
KWF
van Die IM /
Giovannetti E
Targeting Galectin 4 as a novel molecular target for prognostic
and therapeutic purposes in pancreatic cancer
KWF
van Egmond M
Combining IgG and IgA mAbs therapy to overcome the
immunosuppressive environment that hampers effective anticancer treatment
KWF
van Grieken NCT
Predictive biomarkers for response to chemotherapy in gastric
and gastroesophageal adenocarcinomas
KWF
van Grieken NCT
Biological heterogeneity and treatment options in gastrooesophageal and gastric adenocarcinomas
KWF
van Kooyk Y
Improving therapeutic cancer vaccines using a novel glycanpeptide-based approach
KWF
van Vliet SJ
Cracking carbohydrate cues in colorectal and lung cancer
KWF
Vis A
Linking cholesterol and testosterone metabolism to prostate
cancer oncogenesis and disease progression
KWF
Wilting SM
Construction of a discriminatory miRNA marker panel for triage
in hrHPV-based cervical cancer screening
KWF Alpe d'HuZes
Verdonck- de Leeuw IM
ICT4CANCER, facilitating personalized access to supportive care
in cancer survivors
KWF Bas Mulder
Ankersmit M
Intraoperative sentinel lymph node identification in early
colorectal cancer using a multimodal tracer
KWF Bas Mulder
Hopmans W
Sharing is caring: Bridging the gap between information
provision and decision involvement
KWF Fellowship
de Vries SDJ
Molecular profliling of high risk precursor lesions in colorectal
interval carcinomas
KWF Fellowship
de Wit M
Protein Biomarker Development for Detection of Colorectal
Cancer
KWF Fellowship
Voortman J
Let the tumor speak: next generation microRNA sequencing in
laryngeal and hypopharyngeal cancer patients who are treated
with chemoradiation
NWO Middelgroot
Garcia Vallejo JJ
Tissue imaging proteomics
NWO Middelgroot
Peters GJ
“The application of metabolic profiling during pharmacokinetic
monitoring to unravel chemotherapeutic resistance with the
application of liquid chromatography ion trap mass
spectrometry”
NWO VENI
Huijbers EJM
In vivo gene profiling of macrophage phenotypes to identify
novel targets in tumor-associated macrophages
NWO VENI
Smit MA
A genomic approach to identify novel therapy targets
eliminating therapy resistant chronic myeloid leukemia cells
NWO VENI
Voortman J
Let the tumor speak: clinical outcome prediction in larynx and
hypopharyngeal carcinoma by microRNA profiling
NWO VIDI
Giovannetti E
Innovative tools for genetic characterization and therapeutic
discovery in pancreas cancer
NWO VIDI
van Vliet SJ
Cracking carbohydrate cues in colorectal cancer
Reumafonds
Middeldorp JM
Epstein-Barr virus small RNA in exosomes as inflammatory
trigger in Systemic Lupus Erythematosus
STW
van Beijnum JR
miRNA-based strategies for angiostatic tumor therapy
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 195
Grant
Principal investigator
Title
VUmc CCA PhD position
Bitter W
Protein secretion systems of M. tuberculosis as novel target for
drug development'
VUmc CCA PhD position
Boven E
PI3K pathaway analysis in tumor tissue and circulating DNA to
abtain further insight in the efficacy of everolimus in
combination with exestane in postmenopausal patients with
hormone receptor-positve advanced metastatic breast cancer,
who have progressed on anastrozole or letrozole'
VUmc CCA PhD position
Cremers EMP
Emerging role of Flow Cytometry in the diagnosis of cytopenias
of undetermined origin (ICUS) and Myelodysplastics Syndromes
VUmc CCA PhD position
de Jong D
Towards personalized treatment of diffuse large B-cell
lymphoma; an implementation study
VUmc CCA PhD position
Hulleman E
Testing novel treatment modalities for diffuse intrinsic pontine
glioma (DIPG) in in vivo animal models
VUmc CCA PhD position
Jansen G
Novel experimental therapeutics for macrophage targeting n
arthritis and beyond
VUmc CCA PhD position
Kaspers GJL
Sleep, sleep problems and monetary costs to the family of
children with acute leukemia; the effect on quality of life and
parental functioning
VUmc CCA PhD position
van der Vliet JJ
Targeting of CD1d in multiple myeloma
VUmc CCA PhD position
van Helden EJ
Image guided treatment optimalization with cetuximab for
patients with metastatic colorectal cancer: IMPACT - CRC
VUmc CCA PhD position
Ylstra B
Identification of clinically relevant genetic aberrations in
pediatric glioneuronal tumors (GNTs)
CWO-DEC: Animal related protocols
Applicant
Title
Akershoek J
Effect(en) van AT1 blokkers en statines op littekenvorming als gevolg van partial en full
thickness brandwonden
Akershoek JJ
Vergelijking tussen lokale en systemische toediening van een ACE-remmer bij genezing
van halfdiepe brandwonden bij de rat.
Aleyd E
Ontwikkeling van humane IgA monoklonale antilichamen tegen type II collageen in muizen
Aleyd E
De rol van interacties van humaan immunoglobulin A (IgA) monoklonale antilichamen
gericht tegen bovine type II collageen met de IgA Fc receptor (FcαRI) op neutrofielen in
de chronische ontstekingsziekte reumatoïde artritis
Avan A
Study of the role of mesenchymal stem cells conditioned with osteosarcoma exosomes in
the development of osteosarcoma metastases
Baptista A
Lymph node stromal cell-mediated tolerance.
Bijnsdorp I
Speelt CP110 een rol in prostaatkanker metastasering?
Braakhuis B
Ontwikkeling van een realistisch in vivo model ter verbetering van de behandeling van
hoofd-halstumoren (mei 2013) KNO-13-xx
Braakhuis BJM
In stand houden tumorlijnen in immuun-deficiënte muizen ter verbetering van therapie
en diagnostiek van hoofd- halskanker
Braakhuis BJM
Tumorselectieve therapie van hoofd-halskanker met microRNAs in combinatie met
chemoradiatie
Braster R
Geeft een IgG1 met een lagere fucosylering een betere antilichaamtherapie tegen
ontwikkeling van long en peritoneaal carcinoma metastases in muizen
den Haan J
Interactie van siglec-1+ macrofagen met CD8+ DCs: Identificatie van de XCL1
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 196
producerende cel
den Haan J
Interactie van siglec-1+ macrofagen met CD8+ dendritische cellen: Spelen NK cellen hierbij
een belangrijke rol?
den Haan J
Practicum FACS and CFSE Proliferatie Assay (september 2013 en 2014)
den Haan J
Wat beinvloedt de transfer van antigenen tussen siglec-1+ macrofagen en CD8+
dendritische cellen?
den Haan J
Zijn gesialyleerde moleculen op dendritische cellen noodzakelijk voor interactive met
Siglec-1 positieve macrofagen en T cel activatie?
den Haan J
Productie van antilichamen tegen gemodificeerde peptides door middel van targeting
naar siglec-1+ macrofagen
Foster T
The role of the peritoneal membrane in continuous ambulatory peritoneal dialysis
Geldof A
De rol van Gpr27 in stralingsgevoeligheid PC-3 prostaattumoren
Glim J
Het effect van M1 en M2 macrofagen op de wondgenezing
Greijer A
Cytolytische virusactivatie-therapie voor behandeling van Epstein-Barr virus (EBV)
gerelateerde maagcarcinoma
Grewal S
Effecten van lipopolysacharide (LPS) in de uitgroei van chirurgie geïnduceerde
levermetastasen
Griffioen A
Genomic screening of the Embryo for Novel targets in the tumor Endothelium
Gül N
Rol van zuurstof- en stikstofradicalen bij de opname en afbraak van tumorcellen door de
levermacrofagen
Hiddingh L
Combinatie van temozolomide (TMZ) en gamma secretase inhibitors voor de
behandeling van hoog- gradig gliomen
Ilarregui JM
Development of EAE in Gal1/ MGL KO mice
Keuning E
Role of different phosphate binders on absorption of vitamin K and metabolism of
matrix γ-carboxy-glutamaat (Gla) proteïne (MGP)
Koning J
Differentiatie van mesenchymale voorlopers in folliculaire stromale cellen in ontwikkelende
Lagerweij T
Gebruik van radio-sensitiserende therapeutica bij gefractioneerde
bestralingsprotocollen voor de behandeling van hersentumoren
Lagerweij T
Selectie van primaire cellijnen voor 2 vormen van kinderhersentumoren
(medulloblastoom en ependymoom)
Lagerweij T
Study the Role of Glioblastoma Derived Extracellular Vesicles and their Distribution
Legler J
Het maken van transgene vislijnen om de functie van genen bestuderen die een rol
spelen bij de vorming van vetcellen
Legler J
Linking circadian rhythm and lipid metabolism: establishing the effects of endocrine
disrupting chemicals on circadian rhythms in zebrafish
Mebius R
Genereren genetisch gemodificeerde muis ter bestudering van de rol van retinol zuur
op het mucosale immuunsysteem
Sewing ACP
Pre-klinische behandeling van Diffuus Intrinsic Pontine Glioma (DIPG) met doxorubicine
Smit L
De in vivo effectiviteit van toediening van IGFBP7 of het remmen van IGF1R aktiviteit in
eliminatie van acute myeloide leukemie (stam) cellen.
Unger W
Nieuwe vaccine formuleringen voor inductie van tumor-specifieke T cellen
Unger W
Modificatie van antigenen met siaalzuur glycanen voor remming van autoreactieve
immune reacties
van der Stoop P
Uitschakelen van COPB2 sensitizeert invasieve glioblastomacellen voor radiotherapie
van Dongen G
Experimentele diagnostiek en therapie van kanker
van Dongen G
Evaluation of the pharmacokinetic profile of antibody-tracer conjugates based on the
Lx-linker system (Lx)
van Dongen G
Tumor targeting performance of the
89
Zr-labeled humanized anti-HER3 antibody
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 197
GSK2849330
Veninga H
Het effect van targeten van peptides naar verschillende types dendritische cellen en
macrofagen
Veninga H
De rol van macrofagen in de marginale zone in het aanzetten en onderhouden van
immuunresponsen
Windhorst B
PET-imaging en biodistributie studie met 11C gelabeld MLN8237, een Aurora Kinase A
remmer.
Appendix Annual Report 2013 VUmc CCA – Scientific Research Committee - 198
Appendix 10. Evening Lectures
January 15, 2013
Highlights program 1 & 2
Host: Tanja de Gruijl
Remco Nagel: Identification of novel drug targets for lung and head-neck cancer by functional genetic screens
Annelies Turksma: IL-21 in Dendritic Cell or T cell based immunotherapy of cancer
March 19, 2013
Highlights program 1 & 5
Host: Johan de Winter
Viola Verhoef: Comparison of two triage algorithms for women with HPV positive self-samples: direct molecular
methylation marker testing versus cytology via a physician-taken smear
Martin Klein: Quality of life and neurocognitive functioning in patients with primary brain tumors
April 16th, 2013
Highlights program 2 & 3
Host: Guus van Dongen
Wendy Unger: Tolerance induction by sialic acids: friend or foe?
Astrid van der Veldt: Measuring drug delivery in tumours using PET and radiolabelled drugs. The case of bevacizumab
and [11C]docetaxel: refutation of a traditional concept.
May 21, 2013
Highlights program 4 & 5
Host: Remco de Bree
Gwen Griffioen: Synchronous early stage lung tumors: Clinical outcomes following stereotactic ablative radiotherapy.
Debate between Irma Verdonck and Joost Dekker chaired by Frank Snoek (EMGO+): To screen or not to screen for
distress.
September 17, 2013
Highlights program 2 & 4
Host: Frits Peters
Susanna Commandeur: Facing the phases of Mycobacterium tuberculosis: hunting for better TB vaccines.
Wilko Verbakel: Digital tomosynthesis: Achieving sub-millimeter accuracy in patient positioning during radiotherapy
October 15, 2013
Highlights program 5 & 3
Host: Gertjan Kaspers
Corien Eeltink: Sexual life beyond cancer
Tom Wurdinger: Non-invasive blood-based cancer diagnostics
November 19, 2013
Highlights program 4 & 1
Host: Ruud Brakenhoff
Martijn Meijerink: The NanoKnife using irreversible electroporation as a new technique to destroy tumors
Ruud Brakenhoff: HPV as prognostic risk factor in head and neck cancer
December 17, 2013
Highlights program 5 & 2
Host: Irma Verdonck – de Leeuw
Femke Jansen: Quality of life in patients with a colostomy, ileostomy or urostomy
Nuray Gül: Macrophages eliminate circulating tumor cells after monoclonal antibody therapy
Appendix Annual Report 2013 VUmc CCA – Evening Lectures - 199