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VUmc Cancer Center Amsterdam /
VUmc Institute for Cancer & Immunology
CCA/V-ICI
Annual Report 2011
Appendices
Address
VUmc Cancer Center Amsterdam / VUmc Institute for Cancer & Immunology (CCA/V-ICI)
VU University Medical Center
PK 7 Z 182
De Boelelaan 1117
1081 HV Amsterdam
The Netherlands
phone:
e-mail:
website :
(31)20 4443113
vumc-cca@vumc.nl
www.vumc.nl/afdelingen/CCA-V-ICI
1
2
List of contents
Appendices
1.
Organization of CCA/V-ICI
5
2.
Scientific input
9
3.
Newly started PhD projects
23
4.
Scientific output
25
5.
Indicators of esteem
63
6.
Societal impact
101
7.
Ongoing projects
105
8.
International collaboration
133
9.
Scientific Research Committee
137
10.
Evening lectures
145
3
4
Appendix 1: Organization of CCA/V-ICI
Management Board
Management Board (MB) members:
- P.C. Huijgens, oncology research, director of CCA/V-ICI
- G. Kraal, immunology research, deputy director of CCA/V-ICI
- H.J. Bonjer, regionalisation, member from October 1
- W.R. Gerritsen, program director CCA till October 1
- G.C.P.M. Hoskens, manager finances division I
- C.R. Leemans, education, chairman of internal advisory board
- G.A. Meijer, infrastructure, member from October 1
- B.J. Slotman, regionalisation, member from August 22
- H.M.W.Verheul, patient care/fundraising, member
Supportive staff
- J. van Diemen (board assistant)
- Y.M. Duiker (board assistant)
- E. van Kessel (project manager)
- M.A.J. Koelink (senior secretary)
- G.K. Kuipers (senior board assistant)
- H. Loeffen (communication advisor)
- E.M. Ruhé-Hoogervorst (senior board assistant)
- E. Takkenberg (fundraiser)
- J. Zweers (project controller)
Executive Board
The Executive Board (EB) of CCA/V-ICI consists of the program leaders. The EB meets every 2
months together with the MB, chaired by one of the MB directors. The EB advises the MB about:
- research projects
- long-term policy with respect to personnel and materials
5
-
first money stream graduate students
allocation of equipment for research of > € 12.000
patient care projects
clinical and translational research
education
fundraising for cancer research, care and education
early diagnostics
all matters concerning CCA/V-ICI whether on request or not.
The complete EB convenes regularly to discuss the long term policy of CCA/V-ICI.
Executive Board members:
Program 1: Oncogenesis:
- R.H. Brakenhoff
- P.J.F. Snijders
- J. de Winter
Program 2: Immunopathogenesis:
- R.H.J. Beelen
- T.D. de Gruijl
- E. Hooijberg
- Y. van Kooyk
- R. Mebius
Program 3: Disease profiling:
- G.A.M.S. van Dongen
- O.S. Hoekstra
- C. Jimenez
- C.L. Verweij
- T. Würdinger
Program 4: Therapy:
- R. de Bree
- J. Janssen
- G.J. Peters
- S. Senan
- H. van der Vliet
Program 5: Quality of Life
- J. Dekker
- G.J.L. Kaspers
- B.D. Onwuteaka-Philipsen
- I.M. Verdonck
- O. Visser
Internal Advisory Board
The members of the internal advisory board consist of 5 to 10 heads of departments involved in
cancer and immunology within the VUMC. The chairman is member of the MB. The board meets
twice a year.
Internal Advisory Board members:
- C.R. Leemans (Chair)
- M.A. Blankenstein
- J. Bonjer
- C.D. Dijkstra
- J.J. Heimans
- O.S. Hoekstra
- G.C.P.M. Hoskens
- P.C. Huijgens
- G.G. Kenter
6
-
G. Kraal
G.A. Meijer
H. Meijers-Heijboer
C.J.J. Mulder
E.F. Smit
H.M.W. Verheul
A. Voskuyl
Scientific Research Committee (CWO)
The CWO is divided into a section that advises merely animal related protocols and a section that
advises patient related protocols and other project proposals.
The CWO advises about the research policy and about the feasibility of new research projects upon
request of the MB. The CWO advises the MB specifically about the quality and the feasibility of all
research proposals that need permission of the ethical committees for patient related or animal
related research before they can be realized.
Research proposals made on behalf of (inter)nationally recognized joint ventures (EORTC, HOVON,
SIOP, SKION) and multi-center studies in which the VUMC is not the main judging committee, are
judged only marginally on local feasibility.
The CWO also advises on other research proposals for which judgment by the CWO is desired. The
CWO gives asked and unasked advice to the MB about the quality of research within CCA/V-ICI. The
CWO section for patient related protocols meets twice a month, the CWO section for animal related
protocols meets once a month.
The VUMC Management Regulations stipulate that the CCA/V-ICI CWO section for patients related
protocols is composed of 5 to 9 members. In view of the institute’s size and in order to have
sufficient expertise in the different research fields, the CWO has been extended to a maximum of
15 members.
Scientific Research Committee (CWO) members - Section for patient related protocols:
- A.A. van der Loosdrecht (chair)
- A.A. van Bodegraven
- B.J.M. Braakhuis
- A.J.M. van den Eertwegh
- M. van Egmond
- T.D. de Gruijl
- N.H. Hendrikse
- M. Klein (advisor)
- G.K. Kuipers (secretary)
- F.B.J.M. Thunnissen
- A.E. Voskuyl (till May 1)
- Q. Waisfisz
Scientific Research Committee (CWO) members - Section for animal related protocols:
- R. Scheper (chair)
- B.J. Appelmelk
- V. van Beusechem
- G. Kraal
- G.K. Kuipers (secretary)
Committee for Education & Training
This committee supervises and advices about all training and education activities within CCA/V-ICI.
The graduate training is organized within the Oncology Graduate School Amsterdam (OOA) and the
Leiden Amsterdam Institute for Immunology (ALIFI).
More in detail, by means of subgroups, this committee organizes and advises about training in the
framework of the:
- oncology profile
7
-
immunology profile
masters education in oncology
masters education in immunology
graduate students education
postgraduate education
SMBWO (Foundation for the Training of Biomedical Scientists)
NVVI (Dutch Society for Immunology)
all other types of education within CCA/V-ICI.
Each of these subgroups is composed of the main teachers within the education involved. The
committee gives asked and unasked advice about the quality and quality maintenance of education
within CCA/V-ICI. The committee meets at least six times a year.
Members of the Committee for Education & Training:
- C.R Leemans (chair)
- R.H.J. Beelen
- M.M. van Duist
- G.A. Meijer
- E.M. Ruhé-Hoogervorst (secretary)
Subgroups:
Oncology profile committee members:
- B.J.M. Braakhuis
- E. Boven
- A.A. van de Loosdrecht
- N.C.T. van Grieken
- F.B.J.M Thunnissen
- E.M. Ruhé-Hoogervorst (profile coordinator)
Immunology and Infection committee members:
- B.J. Appelmelk
- I.E.M. Bultink
- I. van Hoogstraten
- H.J. Bontkes
- M.B.E. von Blomberg
- G.K. Kuipers (profile coordinator)
Directorate OOA (Oncology Graduate School Amsterdam)
- G.A. Meijer, chairman (VUmc) till September
- A.W. Griffioen from September
- J.P. Medema (AMC) till September 26
- E.M. Ruhé-Hoogervorst, secretary (VUmc)
- T. Sixma (NKI)
- M. Spaargaren (AMC) from September 26
ALIFI PhD committee (Amsterdam Leiden Institute For Immunology)
- R.A.W. van Lier (AMC)
- R.E. Mebius (VUmc-CCA/V-ICI)
- H. Schuitemaker (Sanquin)
Funding by Stichting VUmc CCA
The Stichting VUmc CCA supports VUmc and CCA/V-ICI in their cancer research and care for patients
with cancer.
8
Appendix 2: Scientific input
Appendix 2. Scientific input
Program 1: Oncogenesis
Department
Funding
FTE
Full professor
Oudejans CBM
Clinical Chemistry
1
0,05
Joenje H
Clinical Genetics
1
0,20
Meijers-Heijboer HE
Clinical Genetics
1
0,10
te Riele H
Clinical Genetics
1
0,00
Kenter GG
Obstetrics and Gynaecology
1
0,33
Bloemena E
Oral and Maxillofacial Surgery and Pathology
1
0,20
van der Waal I
1
0,15
Brakenhoff RH
Otolaryngology/Head and Neck Surgery
1
0,85
Leemans CR
1
0,05
Meijer CJLM
Pathology
3
0,17
Meijer GA
Pathology
1
0,10
Middeldorp JM
Pathology
1
0,50
Mooi WJ
Pathology
1
0,10
Peeper DS
Pathology
1
0,00
Snijders PJF
Pathology
1
0,20
Associated professor
Berkhof J
Clinical Epidemiology and Biostatistics
1
1,00
van de Wiel MA
2
0,50
de Winter JP
Clinical Genetics
1
1,00
Jimenez CR
Medical Oncology
1
1,00
Braakhuis BJM
1
0,85
Steenbergen RDM
Pathology
1
0,50
van Egmond M
Surgery
1
0,90
Kuik DJ
1
0,06
Dorsman JC
Clinical Genetics
1
1,00
Menko FH
Clinical Genetics
1
0,10
van Hest LP
Clinical Genetics
1
0,10
Waisfisz Q
Clinical Genetics
1
0,80
Hertog D
1
0,40
Karagozoglu KH
1
0,10
Schulten EAJM
1
0,10
Bleeker MCG
Pathology
1
0,20
Carvalho B
Pathology
3
0,56
Cillessen SAGM
Pathology
3
0,90
Rozendaal L
Pathology
1
0,10
Thunnissen FBJM
Pathology
1
0,20
Assistant professor
van Hattum AH
Pathology
1
0,10
van Kemenade F
Pathology
1
0,10
Gille JJP
Clinical Genetics
1
0,10
de Wit M
Medical Oncology
1
1,00
Bremmer JF
4
0,02
Other tenured staff
Cillessen SAGM
Pathology
3
0,10
Heideman DAM
Pathology
1
0,50
Hesselink AT
Pathology
3
1,00
Hubers J
Pathology
3
1,00
9
Department
Funding
FTE
Pegtel M
Pathology
2
1,00
Rekers N
Pathology
3
0,56
van Boerdonk R
Pathology
3
0,75
Krekel NMA
Surgery
3
1,00
Total tenured staff
20,60
Non tenured staff
Agarwal S
Clinical Genetics
2
0,23
Ameziane N
Clinical Genetics
1
0,83
de Lange J
Clinical Genetics
3
0,16
Oudgenoeg G
Medical Oncology
1
1,00
Pham TV
Medical Oncology
3
0,83
Schaaij-Visser BM
Medical Oncology
1
1,00
van Beynum JR
Medical Oncology
3
1,00
Vermeulen C
Medical Oncology
3
0,58
Ferns D
1
1,00
Jordanova ES
1
0,70
Nagel R
2
1,00
Smeets SJ
3
0,07
Bosch LJW
Pathology
3
0,66
Lalic D
Pathology
3
0,83
Wilting SM
Pathology
3
1,00
Adank M
Clinical Genetics
1
0,75
Bakker JL
Clinical Genetics
1
0,75
Corbin M
Clinical Genetics
2
0,75
Dommering CJ
Clinical Genetics
1
0,10
Faramarz A
Clinical Genetics
2
0,56
Haitjema A
Clinical Genetics
3
0,75
Kooi EI
Clinical Genetics
3
0,10
Massink M
Clinical Genetics
2
0,75
Mol BM
Clinical Genetics
3
0,75
PhD students
Roohollahi K
Clinical Genetics
Stoepker C
Clinical Genetics
1
0,75
de Leeuw DC
Hematology
3
0,37
Gotink KJ
Medical Oncology
3
0,75
Heusschen R
Medical Oncology
3
0,75
Neerincx M
Medical Oncology
3
0,75
Paulis YWJ
Medical Oncology
3
0,75
Dekker H
3
0,25
Dekker H
1
0,20
Matse JH
1
0,40
Ramawadh RS
1
0,05
Graveland APJ
1
0,10
Martens-de Kemp SR
1
0,63
Rietbergen MM
3
0,75
van der Plas M
3
0,75
Bierkens M
Pathology
1
0,44
de Strooper LMA
Pathology
3
0,69
Henken FE
Pathology
3
0,28
Hiemstra AC
Pathology
3
0,20
Mollers M
Pathology
3
0,75
10
Department
Funding
FTE
Novalic Z
Pathology
3
0,58
Ramayanti O
Pathology
3
0,35
Scherpenisse M
Pathology
3
0,75
Schütze DM
Pathology
3
0,75
Snellenberg S
Pathology
3
0,75
van den Broek E
Pathology
1
0,33
Verweij FJ
Pathology
3
0,75
Haloua JP
Surgery
3
0,75
Total non tenured staff
30,78
Total research staff
51,38
Program 2: Immunopathogenesis
Department
Funding
FTE
Full professor
Starink TM
Dermatology
1
0,10
Mulder CJJ
Gastroenterology
1
0,07
Bitter W
Medical Microbiology and Infection Control
1
0,35
Vandenbroucke-Grauls CMJE
1
0,12
Beelen RHJ
Molecular Celbiology and Immunology
1
0,50
Dijkstra CD
1
0,05
Kraal G
1
0,60
Mebius RE
1
0,80
van Kooyk Y
1
0,60
Scheper RJ
Pathology
1
0,30
van den Elsen PJ
Pathology
1
0,10
Verweij CL
Pathology
1
0,10
Dijkmans BAC
Reumatology
1
0,03
Gibbs S
Dermatology
1
0,80
Gibbs S
Dermatology
2
0,20
Stoof TJ
Dermatology
1
0,10
Appelmelk BJ
1
0,70
van Die IM
1
0,60
von Blomberg BME
Pathology
1
0,10
de Boer EM
Dermatology
1
0,10
Franken SM
Dermatology
1
0,30
Kirtschig G
Dermatology
1
0,05
Rustemeyer T
Dermatology
1
0,30
van Montfrans C
Dermatology
1
0,20
Assistant professor
Felt-Bersma RJF
Gastroenterology
1
0,20
van Bodegraven AA
Gastroenterology
1
0,20
van Nieuwkerk CMJ
Gastroenterology
1
0,20
Ang W
1
0,05
van der Sar AM
1
0,55
van den Eertwegh AJM
Medical Oncology
1
0,10
den Haan JMM
2
0,60
Douma CE
Nefrology
3
0,20
Farhat K
Nefrology
1
0,20
Nurmohamed SA
Nefrology
1
0,15
11
Department
Funding
FTE
Rüger JW
Nefrology
1
0,20
Mulder MF
Paediatrics
1
0,10
van der Plas RN
Paediatrics
1
0,00
Hooijberg E
Pathology
3
0,50
Morré SA
Pathology
1
0,10
van den Tol MP
Surgery
1
0,20
Menckeberg C
2
0,12
van Vliet SJ
2
1,00
Crusius JBA
Pathology
1
0,10
Gross S
Pathology
3
0,75
Ouburg S
Pathology
3
1,00
Other tenured staff
Scheffer GL
Pathology
3
0,50
van Hoogstraten IMW
Pathology
1
0,00
Total tenured staff
14,19
Non tenured staff
Reijnders CMA
Dermatology
2
1,00
Reinders J
Dermatology
2
1,00
Abdallah AM
3
0,13
Bestebroer J
3
0,65
Geurtsen J
2
0,75
Houben E
2
0,05
Houben E
1
0,70
Ambrosini M
3
1,00
Bakema JE
2
0,33
Garcia-Vallejo JJ
2
1,00
Ilarregui JM
3
1,00
Koning JJ
2
1,00
Koning N
4
1,00
Kuijk LM
3
1,00
Lenos KJ
3
1,00
Molenaar R
2
0,25
Papadopoulos P
2
1,00
Tefsen B
2
1,00
Unger WWJ
2
0,67
van Beelen AJ
1
0,42
van de Pavert SA
2
1,00
Veninga H
3
1,00
Vos JB
2
0,42
Broers CJM
Paediatrics
1
0,20
van der Kuip M
Paediatrics
1
0,20
0,10
Bontkes HJ
Pathology
1
Gelderman KA
Pathology
1
0,10
Greijer AE
Pathology
2
0,83
PhD students
Kosten IJ
Dermatology
1
0,75
Limandjaja GC
Dermatology
2
0,75
van den Broek L
Dermatology
3
0,75
Vink L
Dermatology
4
0,75
Lam TJ
Gastroenterology
4
0,13
Ates LS
1
0,69
12
Department
Funding
FTE
Daleke M
2
0,70
Stoop EJM
3
0,75
van de Weerd R
2
0,75
van der Woude AD
1
0,06
Weerdenburg EM
1
0,75
Lam SW
Medical Oncology
3
0,75
Beijer MR
1
0,75
Bloem K
4
0,75
Bogels M
1
0,50
Braster R
1
0,30
da Silva Aresta Belo van Wijk AI
4
0,75
Fehres CM
3
0,75
Galama SM
2
0,75
Goverse G
2
0,75
Grewal SK
2
0,25
Gul N
1
0,60
Hiemstra IH
1
0,75
Klaver EJ
1
0,75
Ouwehand I
1
0,47
Perdicchio M
2
0,75
Stavenuiter AWD
2
0,75
van der Steen LPE
2
0,75
van Hout MWM
2
0,75
Walraven M
3
0,20
Yildirim C
1
0,75
Mason S
Paediatrics
2
0,00
Msoka T
Paediatrics
3
0,00
Solomons R
Paediatrics
2
0,00
van Dungen F
Paediatrics
1
0,20
van Elsland S
Paediatrics
3
0,00
de Jong T
Pathology
3
0,75
Hoebe EK
Pathology
3
0,38
Lubbers J
Pathology
3
0,75
Turksma A
Pathology
3
0,69
Nielsen K
Surgery
3
0,75
41,97
56,18
Program 3: Disease profiling
Department
Funding
FTE
Full professor
Blankenstein MA
Clinical Chemistry
3
0,05
Mulder CJJ
Gastroenterology
1
0,07
Peña AS
Gastroenterology
1
0,00
Huijgens PC
Hematology
1
0,10
Kluytmans J
1
0,10
Savelkoul PHM
1
0,15
1
0,13
Dijkstra CD
1
0,05
Heimans JJ
Neurology
1
0,06
13
Department
Funding
FTE
Taphoorn MJB
Neurology
1
0,00
Comans EFI
Nuclear Medicine and PET Research
1
0,20
Hoekstra OS
1
0,30
Lammertsma AA
1
0,15
de Bree R
1
0,10
Leemans CR
1
0,05
van Dongen GAMS
1
0,85
Bloemena E
Pathology
1
0,10
Meijer CJLM
Pathology
3
0,18
Meijer GA
Pathology
1
0,10
Snijders PJF
Pathology
1
0,20
Verweij CL
Pathology
1
0,10
Wesseling P
Pathology
1
0,05
Postmus PE
Pulmonology
1
0,20
Smit EF
Pulmonology
1
0,20
Castelijns JA
Radiology
1
0,20
Dijkmans BAC
Reumatology
1
0,03
Lems WF
Reumatology
1
0,10
Meijer S
Surgery
1
0,05
2
0,50
Boellaard R
1
0,30
Herscheid JDM
1
0,20
Molthoff CFM
1
0,30
Windhorst AD
1
0,15
Ylstra B
Pathology
1
0,40
van der Horst-Bruinsma IE
Reumatology
1
0,40
Kuik DJ
1
0,06
Baalbergen JM
Hematology
1
0,30
Hekker TAM
1
0,01
Ossenkopp YJ
1
0,01
Smit AM
1
0,01
van der Pouw-Kraan CTM
1
0,90
le Poole CY
Nefrology
1
0,10
Postma TJ
Neurology
1
0,10
Reijneveld JC
Neurology
1
0,10
Raijmakers PG
1
0,05
van Schie A
3
0,10
Visser GWM
1
0,10
Beliën JAM
Pathology
1
0,20
Carvalho B
Pathology
3
0,28
Fijneman RJA
Pathology
3
0,90
Morré SA
Pathology
1
0,10
van Grieken NCT
Pathology
1
0,20
Bahce I
Pulmonology
1
0,20
Becker A
Pulmonology
1
0,20
van de Wiel MA
Assistant professor
Daniels JMA
Pulmonology
1
0,20
Hashemi SMS
Pulmonology
1
0,20
Sutedja TG
Pulmonology
1
0,20
Bultink IEM
Reumatology
1
0,10
14
Department
Funding
FTE
van der Laken CJ
Reumatology
4
0,20
van Schaardenburg D
Reumatology
1
0,05
Voskuyl AE
Reumatology
1
0,10
te Velde EA
Surgery
1
0,20
Kaiser AM
1
0,05
Pettersson Fernholm AM
1
0,01
Reuland EA
3
0,70
van de Laar TJW
1
0,10
Huisman MC
1
0,20
Yaqub MM
1
0,11
Carvalho B
Pathology
3
0,08
Other tenured staff
Crusius JBA
Pathology
1
0,10
de Ridder A
Pathology
2
0,63
Fijneman RJA
Pathology
3
0,10
Parlayan
Pathology
3
1,00
Scheffer GL
Pathology
3
0,50
Sie DLS
Pathology
1
0,40
Hendrikse NH
Pharmacy
1
Total tenured staff
0,30
15,57
Non tenured staff
Douw L
Neurology
3
0,50
Verwer E
3
0,67
Poot AJ
2
1,00
Vugts D
4
0,58
Bosch LJW
Pathology
3
0,33
Díaz-López R
Pathology
2
0,92
van der Velde AG
Pathology
3
0,25
Voorham QJM
Pathology
3
1,00
Vink A
3
0,75
Wubulikasimu A
2
0,38
Wubulikasimu A
1
0,37
Bakker SF
Gastroenterology
2
0,75
Ben Larbi I
Gastroenterology
2
0,38
de Baaij LR
Gastroenterology
3
0,50
Radersma M
Gastroenterology
3
0,75
Seinen ML
Gastroenterology
3
0,75
Terhaar sive Droste JS
Gastroenterology
3
0,40
van de Water JMW
Gastroenterology
1
0,38
van Turenhout ST
Gastroenterology
3
0,75
van Wanrooij RLJ
Gastroenterology
2
0,75
van Weyenberg SJB
Gastroenterology
1
0,00
Budding A
1
0,10
PhD students
Rood IGH
1
0,03
van Cleef BAGL
3
0,19
de Groot M
Neurology
4
0,15
Koekkoek J
Neurology
4
0,10
Sizoo E
Neurology
3
0,25
van Dellen E
Neurology
3
0,32
Cheebsumon P
2
0,75
15
Department
Funding
FTE
Frings V
2
0,75
Hoyng LL
3
0,25
Makris N
4
0,75
Oprea D
4
0,40
Rizvi SN
4
0,40
Flach GB
2
0,10
Hakim S
2
0,07
Heuveling D
4
0,75
Nissen IA
2
0,11
van der Putten L
1
0,10
Vosjan MJWD
2
0,38
Blits M
Pathology
3
0,75
de Groen FLM
Pathology
1
0,75
Goos JACM
Pathology
2
0,75
Haan JC
Pathology
3
0,75
Krijgsman O
Pathology
1
0,75
Scheinin AI
Pathology
3
0,75
Timmer LM
Pathology
3
0,75
van den Broek E
Pathology
1
0,17
van Thuijl HF
Pathology
3
0,75
Voorham QJM
Pathology
3
0,38
Vosslamber S
Pathology
3
0,75
de Langen AJ
Pulmonology
1
0,10
Kuiper JL
Pulmonology
3
0,18
Mellema WW
Pulmonology
3
0,50
Paff T
Pulmonology
3
0,56
Schook R
Pulmonology
1
0,19
Siebring-van Olst E
Pulmonology
1
0,75
Rodjan F
Radiology
3
0,75
de Cuba E
Surgery
1
0,75
van der Pas MHGM
Surgery
2
0,75
29,94
45,52
Program 4: Innovative therapy
Department
Funding
FTE
Full professor
Zuurmond WWA
Anesthesiology
1
0,20
Boers M
1
0,30
Mulder CJJ
Gastroenterology
1
0,06
Huijgens PC
Hematology
1
0,10
Ossenkoppele GJ
Hematology
1
0,30
Boven E
Medical Oncology
1
0,25
Gerritsen WR
Medical Oncology
1
0,25
Griffioen AW
Medical Oncology
1
0,80
Peters GJ
Medical Oncology
1
0,80
Verheul H
Medical Oncology
1
0,25
Heimans JJ
Neurology
1
0,07
Taphoorn MJB
Neurology
1
0,00
Vandertop WP
Neurosurgery
1
0,10
16
Department
Funding
FTE
van der Waal I
1
0,15
de Bree R
1
0,10
Leemans CR
1
0,05
Kaspers GJL
Paediatrics
1
0,20
van Furth AM
Paediatrics
1
0,30
Scheper RJ
Pathology
1
0,30
van der Waal I
Pathology
1
0,10
Senan S
Radiation Oncology
1
0,20
Slotman BJ
Radiation Oncology
1
0,20
Dijkmans BAC
Reumatology
1
0,04
Lems WF
Reumatology
1
0,10
Cuesta MA
Surgery
1
0,05
van Moorselaar RJA
Urology
1
0,10
Anesthesiology
1
0,10
Associated staff
Perez RSGM
Schuurhuis GJ
Hematology
1
0,75
van Agtmael MA
Internal Medicine
1
0,20
de Gruijl TD
Medical Oncology
1
1,00
van Beusechem VW
Medical Oncology
1
1,00
Wurdinger T
Neurosurgery
1
0,30
Assistant professor
Coupe VMH
1
1,00
Kuik DJ
1
0,05
Xavier de Menezes R
1
1,00
Chamuleau MED
Hematology
1
0,30
Cloos J
Hematology
1
0,75
Dräger AM
Hematology
1
0,20
Issa DE
Hematology
4
0,40
Janssen JJWM
Hematology
1
0,30
Thielen N
Hematology
4
0,40
van de Loosdrecht AA
Hematology
1
0,30
Visser O
Hematology
1
0,30
Zweegman S
Hematology
1
0,30
Broxterman HJ
Medical Oncology
1
0,80
Buter J
Medical Oncology
1
0,10
Dressel AJN
Medical Oncology
1
0,10
Konings IRHM
Medical Oncology
1
0,10
van den Eertwegh AJM
Medical Oncology
1
0,10
van der Houven van Oordt CW
Medical Oncology
1
0,20
van der Vliet JJ
Medical Oncology
1
0,30
van der Vorst MJDL
Medical Oncology
1
0,20
van Linde ME
Medical Oncology
1
0,20
Postma TJ
Neurology
1
0,10
Reijneveld JC
Neurology
1
0,10
Baayen JC
Neurosurgery
1
0,05
de Witt Hamer PC
Neurosurgery
1
0,30
Feller RE
Neurosurgery
1
0,00
Noske DP
Neurosurgery
1
0,30
Peerdeman SM
Neurosurgery
1
0,10
Moll AC
Opthalmonology
1
0,05
Eerenstein SEJ
1
0,02
17
Department
Funding
FTE
van Weert S
1
0,02
Oeij NA
Paediatrics
1
0,10
Dahele MR
Radiation Oncology
1
0,05
Doornaert P
Radiation Oncology
1
0,05
Haasbeek CJ
Radiation Oncology
1
0,05
Lafleur MVM
Radiation Oncology
1
0,05
Lagerwaard FJ
Radiation Oncology
1
0,05
Sminia P
Radiation Oncology
1
0,40
Bultink IEM
Reumatology
1
0,10
van Schaardenburg D
Reumatology
1
0,05
Voskuyl AE
Reumatology
1
0,10
Geldof AA
Urology
1
0,30
Vis A
Urology
1
0,10
Bogaards JA
3
0,50
Bongers ML
3
1,00
van Oostveen JW
Hematology
1
0,05
Dong W
Medical Oncology
4
1,00
Other tenured staff
Labots M
Medical Oncology
3
0,10
Meulenberg JJ
Medical Oncology
4
0,75
Piersma SR
Medical Oncology
3
0,80
Rovithi MN
Medical Oncology
3
0,80
van Dijk J
Medical Psychology
3
0,40
Froklage F
Neurology
2
0,75
Berenguer de Felipe J
Neurosurgery
2
0,83
Langius JAE
Nutricion and dietics
3
1,00
Wierdsma NJ
1
0,22
Abbink F
Paediatrics
1
0,10
Thijssen VLJL
Radiation Oncology
3
0,60
van Sörnsen de Koste JR
Radiation Oncology
1
0,20
Jansen G
Reumatology
1
1,00
ter Wee MM
Reumatology
4
1,00
van Dam DA
Surgery
3
1,00
Total tenured staff
30,66
Non tenured staff
Demirel E
3
Noordhuis P
Hematology
4
1,00
0,20
Smit L
Hematology
1
0,25
Giovannetti E
Medical Oncology
2
1,00
Honeywell R
Medical Oncology
1
1,00
Douw L
Neurology
3
0,50
van der Stoop PM
Neurosurgery
2
0,80
Hulleman E
Paediatrics
3
0,80
Mahdavian Delawary B
Plastic, reconstructive and handsurgery
2
0,75
van Tuyl L
Reumatology
3
0,66
Bijnsdorp IV
Urology
3
1,00
Jacobs JJL
Urology
3
0,67
Chaturvedi N
3
0,75
Taghipour Bazargani Y
3
0,18
de Boer YS
Gastroenterology
2
0,25
PhD students
18
Department
Funding
FTE
van Gerven NMF
Gastroenterology
3
0,50
Alhan C
Hematology
4
0,75
Bachas C
Hematology
3
0,25
de Leeuw DC
Hematology
3
0,38
Irandoust M
Hematology
3
0,13
Niewerth D
Hematology
3
0,75
Regelink JC
Hematology
4
0,40
Ruben JM
Hematology
3
0,75
van den Ancker W
Hematology
1
0,06
van Luijn M
Hematology
3
0,50
Verhagen HJMP
Hematology
3
0,25
Wojtuszkiewicz A
Hematology
3
0,75
Wondergem MJ
Hematology
1
0,30
Wouters FR
Hematology
3
0,38
Zeijlemaker W
Hematology
3
0,34
Zeijlemaker W
Hematology
1
0,35
Avan A
Medical Oncology
4
0,75
Azijli K
Medical Oncology
2
0,75
de Bruin R
Medical Oncology
3
0,75
El-Naggar M
Medical Oncology
4
0,75
Galvani E
Medical Oncology
4
0,75
Hodzic J
Medical Oncology
3
0,75
Huijts L
Medical Oncology
1
0,40
Huijts L
Medical Oncology
3
0,35
Kuipers-de Wilt LHAM
Medical Oncology
3
0,75
Neefjes ECW
Medical Oncology
3
0,75
Schneiders FL
Medical Oncology
1
0,75
Schulkens I
Medical Oncology
3
0,75
van der Mijn JC
Medical Oncology
4
0,75
van der Wijk LJ
Medical Oncology
3
0,75
Warmoes M
Medical Oncology
3
0,75
de Groot M
Neurology
4
0,16
Koekkoek J
Neurology
4
0,10
Sizoo E
Neurology
3
0,25
van Dellen E
Neurology
3
0,33
Caretti V
Neurosurgery
4
0,75
Hiddingh L
Neurosurgery
3
0,75
Smits M
Neurosurgery
1
0,75
van Rijn S
Neurosurgery
3
0,75
Posthuma de Boer J
Orthopaedics
4
0,38
Cohen R
2
0,75
Slobbe P
3
0,25
Vosjan MJWD
2
0,37
Blufpand HN
Paediatrics
4
0,75
Franke N
Paediatrics
3
0,75
Jansen MHA
Paediatrics
4
0,75
Kors WA
Paediatrics
1
0,20
Mir SE
Paediatrics
1
0,10
van Vuurden DG
Paediatrics
1
0,50
van Well G
Paediatrics
Wilhelm AJ
Pharmacy
0,00
1
0,20
19
Department
Funding
FTE
Narayan RS
Radiation Oncology
3
0,30
Ong CL
Radiation Oncology
3
0,60
Phernambucq E
Radiation Oncology
1
0,00
Bruijnen STG
Reumatology
4
0,75
den Uyl D
Reumatology
3
0,13
Gent YYJ
Reumatology
3
0,75
Raterman HG
Reumatology
4
0,10
Verbrugge CSE
Reumatology
1
0,75
Weijers K
Reumatology
3
0,75
Ankersmit M
Surgery
3
0,63
40,75
70,45
Program 5: Quality of life
Department
Funding
FTE
Full professor
Heimans JJ
Neurology
1
0,07
Taphoorn MJB
Neurology
1
0,00
Festen JM
1
0,05
Leemans CR
1
0,05
Verdonck-de Leeuw IM
1
0,60
Kaspers GJL
Paediatrics
1
0,20
Veerman AJP
Paediatrics
1
0,00
Dekker J
Rehabilitation Medicine
1
0,10
Reijneveld JC
Neurology
1
0,10
Rinkel RNPM
1
0,05
van Dijk EM
Medical Psychology
3
0,30
van Uden-Kraan CF
1
1,00
Veening MA
Paediatrics
1
0,10
Scholte-Voshaar M
Reumatology
1
0,05
Assistant professor
Other tenured staff
Total tenured staff
2,67
Non tenured staff
Mostert SM
Paediatrics
4
0,27
van der Berg MH
Paediatrics
3
0,78
van Dulmen-den Broeder E
Paediatrics
4
0,80
Medical Psychology
3
0,50
PhD students
Boele F
Sizoo E
Neurology
3
0,25
Buskermolen S
3
0,50
Cnossen IC
4
0,67
de Bruijn M
3
0,70
Krebber AMH
2
0,75
Lubberding S
2
0,72
van Gogh CDL
1
0,05
van Nieuwenhuizen AJ
4
0,19
Braam KI
Paediatrics
3
0,75
Gordijn MS
Paediatrics
3
0,75
Overbeek A
Paediatrics
3
0,75
20
Department
van Litsenburg R
Total non terured staff
Paediatrics
Funding
FTE
1
0,75
9,18
11,85
21
22
Appendix 3: Newly started PhD projects
PhD student
Project leader
Department
Project
Program
Ankersmit M
Meijerink WJHJ
Surgery
Photoimmunodetection of colorectal cancer
4
Ates LS
Bitter W
Medical Microbiology
and Infection Control
Live mycobacterium bovis BCG bacteria as a
platform for the induction of enhanced tumorantigen-specific immunity
2
Braster R
Beelen RHJ
Molecular Celbiology
and Immunology
Identification of tumor-derived proteins that
modulate macrophage effector functions
2
Buskermolen S
Verheul H
Prevalence and biomarkers of pre-cachexia and
cachexia in advanced cancer patients
scheduled for treatment with chemotherapy
5
Gordijn MS
Kaspers GJL
Paediatrics
Glucocorticoid induced HPA axis suppression in
childhood acute lymphoblastic leukaemia and
lymphoma
5
Grewal S
Beelen RHJ
Molecular Celbiology
and Immunology
Colorectal cancer surgery: a Trojan horse for
liver metastases?
2
Heuveling DH
de Bree R
Otolaryngology/Head
and Neck Surgery
Electrochemotherapy
4
Hiemstra AC
Meijer GA
Pathology
Development of an improved molecular test for
population-wide colorectal cancer screening
1
Hoyng LL
Boellaard R
Nuclear Medicine &
PET research
Quantitative imaging in cancer: connecting
cellular processes with therapy: Data and
Image Analysis (WP4)
3
Huijts L
Verheul H
Medical Oncology
Phase I-II study of everolimus and low-dose oral
cyclophosphamide in patients with metastatic
RCC
4
Kooi EI
te Riele H
Clinical Genetics
Genomics to improve diagnostics and care of
retinoblastoma patients
1
Lubbers J
Verweij CL
Pathology
Genomic biomarkers to predict development of
RA (VERA, ERA) and therapy responsiveness
(ESRA)
3
Mellema WW
Smit EF
Pulmonology
Nieuwe behandelingsmogelijkheden bij
longkankerpatienten met een K-RAS mutatie
4
Narayan RS
Slotman BJ
Radiation Oncology
Targeting resistance to radio-chemotherapy by
inhibition of the PI3Kinase-Akt signaling
pathway
4
Neefjes ECW
Verheul HMW
Medical Oncology
Early recognition and optimal treatment of
delirium in patients with advanced cancer
5
Neerincx M
Verheul HM
Medical Oncology
Individualized treatment of patients with
advanced colorectal cancer based on miRNA
expression profiling
4
Ramayanti O
Middeldorp JM
Pathology
Epstein barr virus activation and cytolytic
antivirual therapy in nasopharyngeal patients
4
Scheinin AI
Meijer GA
Pathology
Data mining DNA copy number changes in
cancer
1
Slobbe P
van Dongen GAMS
Otolaryngology/Head
and Neck Surgery
The development of radiolabeled tyrosine
kinase inhibitors for PET imaging
3
van den Broek E
Meijer GA
Pathology
Structural chromosomal rearrangements in
colorectal cancer
1
Verhagen H
Smit L
Hematology
The identification of biomarkers/drugtargets
specific for leukemic stem cells of Acute
Myeloid Leukemia
4
23
Walraven M
Verheul H
Medical Oncology
Toxicity of angiogenesis inhibitors
4
Zeijlemaker W
Ossenkoppele GJ
Hematology
The role of minimal residual disease, and
leukemic stem cells herein, in clinical decision
making
4
24
Appendix 4: Scientific output
Abbreviations:
(x /y):
After publications, x: quartile score (1-5), y: Impact Factor of journal
1:
Quartile score: SCI journal from lowest quarter, publications in peer-reviewed journals without an Impact Factor
2:
Quartile score: SCI journal from the second quarter (>25th and < 50th percentile)
3:
Quartile score: SCI journal from the third quarter (>50th and < 75th percentile)
4:
Quartile score: SCI journal belonging to the highest quarter 75th-90th percentile
5:
Quartile score: SCI journal belonging to > 90th percentile
(Cat.A): Dissertations prepared and defended at VUmc
(Cat.B): Dissertations prepared elsewhere and defended at VUmc
(Cat.C): Dissertations prepared at VUmc and defended elsewhere
(Cat.D): Dissertations prepared and defended elsewhere
Program 1: Oncogenesis
Scientific papers refereed
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
Adank MA, Jonker MA, Kluijt I, van Mil SE, Oldenburg RA, Mooi WJ, Hogervorst FBL, van den Ouweland AMW, Gille JJP,
Schmidt MK, van der Vaart AW, Meijers-Heijboer EJ, Waisfisz Q. CHEK2*1100delC homozygosity is associated with a high
breast cancer risk in women. J Med Chem 2011; 48: 860-863 (5 / 5.207)
Alibegashvili T, Clifford GM, Vaccarella S, Baidoshvili A, Gogiashvili L, Tsagareli Z, Kureli I, Snijders PJF, Heideman DAM,
van Kemenade FJ, Meijer CJLM, Kordzaia D, Franceschi S. Human papillomavirus infection in women with and without
cervical cancer in Tbilisi, Georgia. Cancer Epidem Biomar 2011; 35: 465-470 (5 / 4.190)
Antoniou AC, Kartsonaki C, Sinilnikova OM, Soucy P, McGuffog L, Healey S, Lee A, Peterlongo P, Manoukian S, Peissel B,
Zaffaroni D, Cattaneo E, Barile M, Pensotti V, Pasini B, Dolcetti R, Giannini G, Putignano AL, Varesco L, Radice P, Mai
PL, Greene MH, Andrulis IL, Glendon G, Ozcelik H, Thomassen M, Gerdes AM, Kruse TA, Jensen UB, Cruger DG, Caligo
MA, Laitman Y, Milgrom R, Kaufman B, Paluch-Shimon S, Friedman E, Loman N, Harbst K, Lindblom A, Arver B,
Ehrencrona H, Melin B, Nathanson KL, Domchek SM, Rebbeck T, Jakubowska A, Lubinski J, Gronwald J, Huzarski T,
Byrski T, Cybulski C, Gorski B, Osorio A, Cajal TRY, Fostira F, Andres R, Benitez J, Hamann U, Hogervorst FB, Rookus MA,
Hooning MJ, Nelen MR, van der Luijt RB, van Os TAM, van Asperen CJ, Devilee P, Meijers-Heijboer EJ, Garcia EBG, Peock
S, Cook M, Frost D, Platte R, Leyland J, Evans DG, Lalloo F, Eeles R, Izatt L, Adlard J, Davidson R, Eccles D, Ong KR,
Cook J, Douglas F, Paterson J, Kennedy MJ, Miedzybrodzka Z, Godwin A, Stoppa-Lyonnet D, Buecher B, Belotti M, Tirapo
C, Mazoyer S, Barjhoux L, Lasset C, Leroux D, Faivre L, Bronner M, Prieur F, Nogues C, Chenevix-Trench G. Common
alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol
Genet 2011; 20: 3304-3321 (5 / 8.058)
Becker A, Crombag L, Heideman DAM, Thunnissen FBJM, van Wijk AW, Postmus PE, Smit EF. Retreatment with erlotinib:
Regain of TKI sensitivity following a drug holiday for patients with NSCLC who initially responded to EGFR-TKI
treatment. Eur J Cancer 2011; 47: 2603-2606 (4 / 4.944)
Bogaards JA, Berkhof J. Assessment of herd immunity from human papillomavirus vaccination. Lancet Infect Dis 2011;
11: 896 (5 / 16.144)
Bogaards JA, Coupe VMH, Meijer CJLM, Berkhof J. The clinical benefit and cost-effectiveness of human papillomavirus
vaccination for adult women in the Netherlands. Vaccine 2011; 29: 8929-8936 (4 / 3.572)
Bogaards JA, Coupe VMH, Xiridou M, Meijer CJLM, Wallinga J, Berkhof J. Long-term Impact of Human Papillomavirus
Vaccination on Infection Rates, Cervical Abnormalities, and Cancer Incidence. Epidemiology 2011; 22: 505-515 (5 /
5.866)
Bogaards JA, Krezschmar M, Xiridou M, Meijer CJLM, Berkhof J, Wallinga J. Sex-specific immunization for sexually
transmitted infections such as human papillomavirus: insights from mathematical models. PLOS Med 2011; 8(12):
e1001147 (5 / 15.617)
Bosch LJW, Carvalho B, Fijneman RJA, Jimenez CR, Pinedo HM, van Engeland M, Meijer GA. Molecular Tests for
Colorectal Cancer Screening. Clin Colorectal Cancer 2011; 10: 8-23 (3 / 2.632)
Casabonne D, Reina O, Benavente Y, Becker N, Maynadi├® M, Foretov├í L, Cocco P, Gonz├ílez-Neira A, Nieters A,
Boffetta P, Middeldorp JM, de Sanjose S. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and
tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European
case-control study EpiLymph. Haematol-Hematol J 2011; 96: 323-327 (4 / 6.532)
Castella M, Pujol R, Callen E, Trujillo JP, Casado JA, Gille JJP, Lach FP, Auerbach AD, Schindler D, Benitez J, Porto B,
Ferro T, Munoz A, Sevilla J, Madero L, Cela E, Belendez C, de Heredia CD, Olive T, de Toledo JS, Badell I, Torrent M,
Estella J, Dasi A, Rodriguez-Villa A, Gomez P, Barbot J, Tapia M, Molines A, Figuera A, Bueren JA, Surralles J. Origin,
functional role, and clinical impact of Fanconi anemia FANCA mutations. Blood 2011; 117: 3759-3769 (5 / 10.558)
Castellsague X, Diaz M, Vaccarella S, de Sanjose S, Munoz N, Herrero R, Franceschi S, Meijer CJLM, Bosch FX.
Intrauterine device use, cervical infection with human papillomavirus, and risk of cervical cancer: a pooled analysis of
26 epidemiological studies. Lancet Oncol 2011; 12: 1023-1031 (5 / 17.764)
Castellsague X, Diaz M, Vaccarella S, de SanjoseS., ., unoz N, Herrero R, Franceschi S, Meijer CJLM, Bosch FX.
Intrauterine device and cervical cancer: we need more evidence - Authors' reply. Lancet Oncol 2011; 12: 1186-1187 (5 /
17.764)
Ceccaldi R, Briot D, Larghero J, Vasquez N, d'Enghien CD, Chamousset D, Noguera ME, Waisfisz Q, Hermine O, Pondarre
C, Leblanc T, Gluckman E, Joenje H, Stoppa-Lyonnet D, Socie G, Soulier J. Spontaneous abrogation of the G(2) DNA
damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients. J Clin Invest 2011;
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Cox DG, Simard J, Sinnett D, Hamdi Y, Soucy P, Ouimet M, Barjhoux L, Verny-Pierre C, McGuffog L, Healey S, Szabo C,
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Gschwantler-Kaulich D, Blum JL, Tung N, Weitzel J, Lynch H, Garber J, Easton DF, Peock S, Cook M, Oliver CT, Frost D,
Conroy D, Evans DG, Lalloo F, Eeles R, Izatt L, Davidson R, Chu C, Eccles D, Selkirk CG, Daly M, Isaacs C, Stoppa-Lyonnet
D, Sinilnikova OM, Buecher B, Belotti M, Mazoyer S, Barjhoux L, Verny-Pierre C, Lasset C, Dreyfus H, Pujol P, CollongeRame MA, Rookus MA, Verhoef S, Kriege M, Hoogerbrugge N, Ausems MGEM, Os TA, van Wijnen J, Devilee P, MeijersHeijboer EJ, Blok MJ, Heikkinen T, Nevanlinna H, Jakubowska A, Lubinski J, Huzarski T, Byrski T, Durocher F, Couch FJ,
Lindor NM, Wang XS, Thomassen M, Domchek S, Nathanson K, Caligo MA, Jernstrom H, Liljegren A, Ehrencrona H, For
PK, Ganz PA, Olopade OI, Tomlinson G, Neuhausen S, Antoniou AC, Chenevix-Trench G, Rebbeck TR. Common Genetic
Variation at BARD1 Is Not Associated with Breast Cancer Risk in BRCA1 or BRCA2 Mutation Carriers. Cancer Epidem
Biomar 2011; 20: 1032-1038 (5 / 4.190)
71. Stoepker C, Hain K, Schuster B, Hilhorst-Hofstee Y, Rooimans MA, Steltenpool J, Oostra AB, Eirich K, Korthof ET,
Nieuwint AWM, Jaspers NGJ, Bettecken T, Joenje H, Schindler D, Rouse J, de Winter JP. SLX4, a coordinator of
structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet 2011; 43: 138-141 (5 /
36.377)
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72. Swarts DR, Claessen SM, Jonkers YM, van Suylen RJ, Dingemans AMC, de Herder WW, de Krijger RR, Smit EF, Thunnissen
FBJM, Seldenrijk CA, Vink A, Perren A, Ramaekers FCS, Speel EJM. Deletions of 11q22.3-q25 Are Associated with
Atypical Lung Carcinoids and Poor Clinical Outcome. Am J Pathol 2011; 179: 1129-1137 (5 / 5.224)
73. Terhaar sive Droste JS, Oort FA, van der Hulst RWM, Van Heukelem HA, Loffeld RJ, van Turenhout ST, Ben Larbi I, Kanis
SL, Neerincx M, Rakers M, Coupe VMH, Bouman AA, Meijer GA, Mulder CJJ. Higher Fecal Immunochemical Test Cutoff
Levels: Lower Positivity Rates but Still Acceptable Detection Rates for Early-Stage Colorectal Cancers. Cancer Epidem
Biomar 2011; 20: 272-280 (5 / 4.190)
74. Terhaar sive Droste JS, Oort FA, van Turenhout ST, Meijer GA, Mulder CJJ. FIT Performance in Early-Stage Colorectal
Cancer-Response. Cancer Epidem Biomar 2011; 20: 1563 (5 / 4.190)
75. Tibaldi C, Giovannetti E, Vasile E, Boldrini L, Gallegos-Ruiz MI, Bernardini I, Incensati R, Danesi R, Cappuzzo F, Peters
GJ, Fontanini G. Inherited Germline T790M Mutation and Somatic Epidermal Growth Factor Receptor Mutations in Nonsmall Cell Lung Cancer Patients. J Thorac Oncol 2011; 6: 395-396 (4 / 4.04)
76. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, van Schil PE,
Garg K, Austin JHM, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, SanchezCespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D,
Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA,
Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen FBJM, Tsao M, Yankelewitz D. International Association for the Study
of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of
Lung Adenocarcinoma. J Thorac Oncol 2011; 6(2): 244-285 (4 / 4.04)
77. Uiterwaal MT, Mooi WJ, van Weyenberg SJB. Metastatic melanoma of the ampulla of Vater. Digest Liver Dis 2011; 43(4):
e8 (3 / 2.805)
78. Vaccarella S, Clifford GM, Howell-Jones R, Snijders PJF, Franceschi S. Author's reply to: Multiple human papillomavirus
genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and
determinants. Int J Cancer 2011; 129: 1283-1285 (4 / 4.926)
79. van Boerdonk RAA, Sutedja TG, Snijders PJF, Reinen E, Wilting SM, van de Wiel M, Thunnissen FBJM, Duin S, Kooi C,
Ylstra B, Meijer CJLM, Meijer GA, Grunberg K, Daniels JMA, Postmus PE, Smit EF, Heideman DAM. DNA Copy Number
Alterations in Endobronchial Squamous Metaplastic Lesions Predict Lung Cancer. Am J Resp Crit Care 2011; 184: 948-956
(5 / 10.191)
80. van de Wiel MA, Picard F, van Wieringen WN, Ylstra B. Preprocessing and downstream analysis of microarray DNA copy
number profiles. Brief Bioinform 2011; 12: 10-21 (5 / 9.283)
81. van den Berg RM, Snijders PJF, Grunberg K, Kooi C, Spreeuwenberg MD, Meijer CJLM, Postmus PE, Smit EF, Steenbergen
RDM. Comprehensive CADM1 promoter methylation analysis in NSCLC and normal lung specimens. Lung Cancer 2011; 72:
316-321 (4 / 3.356)
82. van den Ouweland AMW, Elfferich P, Lamping R, de Graaf R, van Veghel-Plandsoen MM, Franken SM, Houweling AC.
Identification of a large rearrangement in CYLD as a cause of familial cylindromatosis. Fam Cancer 2011; 10: 127-132 (2
/ 2.139)
83. van der Meide WF, Snellenberg S, Meijer CJLM, Baalbergen A, Helmerhorst TJM, Sluis WB, Snijders PJF, Steenbergen
RDM. Promoter methylation analysis of WNT/kappa-catenin signaling pathway regulators to detect adenocarcinoma or
its precursor lesion of the cervix. Gynecol Oncol 2011; 123: 116-122 (5 / 3.760)
84. van der Vrugt HJ, Koomen M, Bakker S, Berns MAD, Cheng NC, van der Valk MA, de Vries Y, Rooimans MA, Oostra AB,
Hoatlin ME, te Riele HPJ, Joenje H, Arwert F. Evidence for complete epistasis of null mutations in murine Fanconi
anemia genes Fanca and Fancg. DNA Repair 2011; 10: 1252-1261 (5 / 4.293)
85. van der Waal I, de Bree R, Brakenhoff R, Coebegh JW. Early diagnosis in primary oral cancer: is it possible?. Med Oral
Patol Oral 2011; 16: e300-e305 (2 / 1.071)
86. van Engeland M, Derks S, Smits KM, Meijer GA, Herman JG. Colorectal Cancer Epigenetics: Complex Simplicity. J Clin
Oncol 2011; 29: 1382-1391 (5 / 18.97)
87. van Weyenberg SJB, Hoentjen F, Thunnissen FBJM, Mulder CJJ. Pseudomelanosis Coli and Adenomatous Polyps. J
Gastrointest Liver Dis 2011; 20: 233 (2 / 1.434)
88. Verweij FJ, van Eijndhoven MA, Hopmans ES, Vendrig T, Wurdinger T, Cahir-McFarland E, Kieff E, Geerts D, Kant R,
Neefjes JJ, Middeldorp JM, Pegtel DM. LMP1 association with CD63 in endosomes and secretion via exosomes limits
constitutive NF-kappa activation. EMBO J 2011; 30: 2115-2129 (5 / 10.124)
89. Vink I, van Kemenade FJ, Meijer CJLM, Casparie MK, Meijer GA, Boomsma DI. Cervix smear abnormalities: linking
pathology data in female twins, their mothers and sisters. Eur J Hum Genet 2011; 19: 108-111 (4 / 4.380)
90. von der Thusen JH, van de Wetering MD, Westermann AM, Heideman DA, Thunnissen FBJM. Bronchioloalveolar
Adenocarcinoma and Pulmonary Langerhans Cell Histiocytosis in a Patient With MUTYH-Associated Polyposis. J Clin
Oncol 2011; 29: e188-e190 (5 / 18.97)
91. Westeinde SC, Koning HJ, Thunnissen FBJM, Oudkerk M, Groen HJ, Lammers JW, Weenink C, Vernhout R, Nackaerts K,
Mali W, van Klaveren RJ. The Role of the (18)F-Fluorodeoxyglucose-Positron Emission Tomography Scan in the
Nederlands Leuvens Longkanker Screenings Onderzoek Lung Cancer Screening Trial. J Thorac Oncol 2011; 6: 1704-1712
(4 / 4.04)
92. Zucali PA, Giovannetti E, Destro A, Mencoboni M, Ceresoli GL, Gianoncelli L, Lorenzi F, De Vicenzo F, Simonelli M,
Perrino M, Bruzzone A, Thunnissen FBJM, Tunesi G, Giordano L, Roncalli M, Peters GJ, Santoro A. Thymidylate Synthase
and Excision Repair Cross-Complementing Group-1 as Predictors of Responsiveness in Mesothelioma Patients Treated
with Pemetrexed/Carboplatin. Clin Cancer Res 2011; 17: 2581-2590 (5 / 7.338)
Scientific papers non-refereed
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2.
3.
Ferreccio C, van de Wyngard V, Olcay F, Dominguez MA, Puschel K, Franceschi S, Snijders PJF. High-risk HPV infection
after five years in a population-based cohort of Chilean women. Infectious Agents and Cancer 2011; 6(1): 21.
Louwers JA, Zaal A, Kocken M, ter Harmsel WA, Graziosi GC, Spruijt JWM, Berkhof J, Balas C, Papagiannakis E, Snijders
PJF, Meijer CJLM, van Kemenade FJ, Verheijen RHM. Dynamic spectral imaging colposcopy: higher sensitivity for
detection of premalignant cervical lesions. Br J Obstet Gynaecol 2011; 118: 309-318.
van der Rhee JI, De Snoo FA, Vasen HFA, Mooi WJ, Putter H, Gruis NA, Kukutsch NA, Bergman W. Effectiveness and
causes for failure of surveillance of CDKN2A-mutated melanoma families. J Am Acad Dermatol 2011; 65: 289-296.
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4.
Young GP, Bosch LJW. Fecal Tests: From Blood to Molecular Markers. Curr Colorectal Cancer Rep 2011; 7: 62-70.
Scientific publications (books, book chapters, proceedings)
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2.
Bleeker MCG, Heideman DAM, Snijders PJF, Horenblas S, Meijer CJLM. Epidemiology of penile cancer and its precursor
lesions; in Muneer A, Arya M, Horenblas S, (eds): Textbook of penile cancer. Springer. 2011.
Heideman DAM, Bleeker MCG, Ahmed HU, Horenblas S, Snijders PJF, Meijer CJLM. Molecular biology of penile cancer;
in Muneer A, Arya M, Horenblas S, (eds): Textbook of penile cancer. Springer. 2011.
Professional publications
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2.
Maas M, Mooi WJ. Modern onderwijs in histopathologie en radiologie. Ned Tijdschr Geneeskd 2011; 155.
van Kemenade FJ, Beerman H. Computerondersteunde cervixscreening. Ned Tijdschr Geneeskd 2011; 155 (18): A2998.
Dissertations
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Bakker ST. Fancm, the mouse that roared. Vrije Universiteit Amsterdam, 12/21/2011. (Co-)promotores: HPJ te Riele,
JP de Winter (cat A)
Bremmer JF. Molecular diagnosis of oral premalignant disorders. Vrije Universiteit Amsterdam, 12/19/2011. (Co)promotores: I van der Waal, RH Brakenhoff, CR Leemans, BJM Braakhuis (cat A)
Henken FE. Essential molecular mechanism contributing to HPV-mediated transformation. Vrije Universiteit
Amsterdam, 9/14/2011. (Co-)promotores: PJF Snijders, CJLM Meijer, RDM Steenbergen (cat A)
Overmeer RM. Altered DNA methylation during HPV-induced cervical carcinogenesis: basic aspects and diagnostic
implications. Vrije Universiteit Amsterdam, 2/4/2011. (Co-)promotores: PJF Snijders, CJLM Meijer, RDM Steenbergen,
(cat A)
Pirog EC. Molecular markers and HPV in the diagnosis of lower genital tract lesions. Vrije Universiteit Amsterdam,
5/23/2011. (Co-)promotores: CJLM Meijer, WGV Quint (cat B)
Smit MA. Dissecting pathways contributing to oncogenic transformation by the tyrosine kinase receptor TrkB. Vrije
Universiteit Amsterdam, 2/24/2011. (Co-)promotores: DS Peeper (cat B)
Terhaar Sive Droste JS. Opportunities and pitfalls in colorectal cancer screening. Vrije Universiteit Amsterdam,
7/6/2011. (Co-)promotores: CJJ Mulder, GA Meijer (cat A)
Vredeveld LCW. Oncogene-induced senescence: from in vitro tool to tumor-suppressive mechanism. Vrije Universiteit
Amsterdam, 6/1/2011. (Co-)promotores: DS Peeper (cat B)
van den Berg RM. Studies on chemoprevention, early detection and prognosis of lung cancer. Vrije Universiteit
Amsterdam, 5/27/2011. (Co-)promotores: EF Smit, PJF Snijders, TG Sutedja, DAM Heideman (cat A)
Program 2: Immunopathogenesis
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Abdallah AM, Bestebroer J, Savage NDL, de Punder K, van Zon M, Wilson L, Korbee CJ, van der Sar AM, Ottenhoff
THM, van der Wel NN, Bitter W, Peters PJ. Mycobacterial Secretion Systems ESX-1 and ESX-5 Play Distinct Roles in
Host Cell Death and Inflammasome Activation. J Immunol 2011; 187: 4744-4753 (4 / 5.745)
Abdul-Careem MF, Mian MF, Gillgrass AE, Chenoweth MJ, Barra NG, Chan T, Al-Garawi AA, Chew MV, Yue G, van
Rooijen N, Xing Z, Ashkar AA. FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection
against lethal influenza infection in mice. Antiviral Res 2011; 92: 346-355 (4 / 4.439)
Agarwal S, van de Loosdrecht AA, Alhan C, Ossenkoppele GJ, Westers TM, Bontkes HJ. Role of immune responses in
the pathogenesis of low-risk MDS and high-risk MDS: implications for immunotherapy. Brit J Dermatol 2011; 153: 568581 (5 / 4.351)
Alexander KA, Chang MK, Maylin ER, Kohler T, Muller R, Wu AC, van Rooijen N, Sweet MJ, Hume DA, Raggatt LJ,
Pettit AR. Osteal Macrophages Promote In Vivo Intramembranous Bone Healing in a Mouse Tibial Injury Model. J Bone
Miner Res 2011; 26: 1517-1532 (5 / 7.056)
Ammerlaan HSM, Kluijtmans JAJW, Berkhout H, Buiting A, de Brauwer EIGB, van den Broek PJ, van Gelderen P,
Leenders SCAP, Ott A, Richter C, Spanjaard L, Spijkerman IJB, van Tiel FH, Voorn GP, Wulf MWH, van Zeijl J,
Troelstra A, Bonten MJM. Eradication of carriage with methicillin-resistant Staphylococcus aureus: determinants of
treatment failure. J Antimicrob Chemoth 2011; 66: 2418-2424 (4 / 4.659)
Ammerlaan HSM, Kluijtmans JAJW, Berkhout H, Buiting A, de Brauwer EIGB, van den Broek PJ, van Gelderen P,
Leenders SCAP, Ott A, Richter C, Spanjaard L, Spijkerman IJB, van Tiel FH, Voorn GP, Wulf MWH, van Zeijl J,
Troelstra A, Bonten MJM. Eradication of carriage with methicillin-resistant Staphylococcus aureus: effectiveness of a
national guideline. J Antimicrob Chemoth 2011; 66: 2409-2417 (4 / 4.659)
Andremont A, Bonten M, Kluijtmans JAJW, Carmeli Y, Cars O, Harbarth S. Fighting bacterial resistance at the root:
need for adapted EMEA guidelines. Lancet Infect Dis 2011; 11: 6-8 (5 / 16.144)
Andriesse GI, Elberts S, Vrolijk A, Verhulst C, Kluijtmans JAJW. Evaluation of a fourth-generation latex agglutination
test for the identification of Staphylococcus aureus. Eur J Clin Microbiol 2011; 30: 259-264 (3 / 2.631)
Ang CW. Author reply to comment by Brandenburg et al. on: Large differences between test strategies for the
detection of anti-Borrelia antibodies are revealed by comparing eight ELISAs and five immunoblots. Eur J Clin
Microbiol 2011; 30: 1035-1037 (3 / 2.631)
Ang CW, Notermans DW, Hommes M, Simoons-Smit AM, Herremans T. Large differences between test strategies for
the detection of anti-Borrelia antibodies are revealed by comparing eight ELISAs and five immunoblots. Eur J Clin
Microbiol 2011; 30: 1027-1032 (3 / 2.631)
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Ang CW, Teunis PFM, Herbrink P, de Keijser J, van Duynhoven YHTP, Visser CE, van Pelt W. Seroepidemiological
studies indicate frequent and repeated exposure to Campylobacter spp. during childhood. Epidemiol Infect 2011; 139:
1361-1368 (3 / 2.257)
Aranzamendi C, Tefsen B, Jansen M, Chiumiento L, Bruschi F, Kortbeek T, Smith DF, Cummings RD, Pinelli E, van Die
IM. Glycan microarray profiling of parasite infection sera identifies the LDNF glycan as a potential antigen for
serodiagnosis of trichinellosis. Exp Parasitol 2011; 129: 221-226 (3 / 1.869)
Arias K, Chu DK, Flader K, Botelho F, Walker T, Arias N, Humbles AA, Coyle AJ, Oettgen HC, Chang HD, van Rooijen N,
Waserman S, Jordana M. Distinct immune effector pathways contribute to the full expression of peanut-induced
anaphylactic reactions in mice. J Allergy Clin Immun 2011; 127: 1552-1561 (5 / 9.273)
Aronson DC, Slaar A, Heinen RC, de Kraker J, Heij HA. Long-Term Outcome of Bilateral Wilms Tumors (BWT). Pediatr
Blood Cancer 2011; 56: 1110-1113 (3 / 1.948)
Arroba AI, varez-Lindo N, van Rooijen N, de la Rosa EJ. Microglia-Mediated IGF-I Neuroprotection in the rd10 Mouse
Model of Retinitis Pigmentosa. Invest Ophth Vis Sci 2011; 52: 9124-9130 (5 / 3.466)
Atai NA, Bansal M, Lo C, Bosman J, Tigchelaar W, Bosch KS, Jonker A, de Witt Hamer PC, Troost D, McCulloch CA,
Everts V, van Noorden CJF, Sodek J. Osteopontin is up-regulated and associated with neutrophil and macrophage
infiltration in glioblastoma. Immunology 2011; 132: 39-48 (3 / 3.302)
Bakema JE, Ganzevles SH, Fluitsma DM, Schilham MW, Beelen RHJ, Valerius T, Lohse S, Glennie MJ, Medema JP, van
Egmond M. Targeting Fc alpha RI on Polymorphonuclear Cells Induces Tumor Cell Killing through Autophagy. J
Immunol 2011; 187: 726-732 (4 / 5.745)
Bakema JE, van Egmond M. Immunoglobulin A: A next generation of therapeutic antibodies?. MABS 2011; 3: 352-361 (4
/ 1.982)
Bakema JE, van Egmond M. The human immunoglobulin A Fc receptor Fc alpha RI: a multifaceted regulator of
mucosal immunity. Mucosal Immunology 2011; 4: 612-624 (4 / 6.817)
Balu S, Reljic R, Lewis MJ, Pleass RJ, McIntosh R, Van Kooten C, van Egmond M, Challacombe S, Woof JM, Ivanyi J. A
Novel Human IgA Monoclonal Antibody Protects against Tuberculosis. J Immunol 2011; 186: 3113-3119 (4 / 5.745)
Bax CJ, Quint KD, peters RP, Ouburg S, Oostvogel PM, Mutsaers JA, Dorr PJ, Schmidt S, Jansen C, Leeuwen AP, Quint
WG, Trimbos JB, Meijer CJLM, Morre SA. Analyses of multiple-site and concurrent Chlamydia trachomatis serovar
infections, and serovar tissue tropism for urogenital versus rectal specimens in male and female patients. Sex Transm
Infect 2011; 87: 503-507 (3 / 3.029)
Bax M, Kuijf ML, Heikema AP, van Rijs W, Bruijns SCM, Garcia Vallejo JJ, Crocker PR, Jacobs BC, van Vliet SJ, van
Kooijk Y. Campylobacter jejuni Lipooligosaccharides Modulate Dendritic Cell-Mediated T Cell Polarization in a Sialic
Acid Linkage-Dependent Manner. Infect Immun 2011; 79: 2681-2689 (4 / 4.098)
Benseler V, Warren A, Vo M, Holz LE, Tay SS, Le Couteur DG, Breen E, Allison AC, van Rooijen N, McGuffog C, Schlitt
HJ, Bowen DG, McCaughan GW, Bertolino P. Hepatocyte entry leads to degradation of autoreactive CD8 T cells. P Natl
Acad Sci USA 2011; 108: 16735-16740 (5 / 9.771)
Bhatia S, Fei MJ, Yarlagadda M, Qi ZB, Akira S, Saijo S, Iwakura Y, van Rooijen N, Gibson GA, St Croix CM, Ray A, Ray
P. Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of
Alternatively Activated Phenotype. PLoS ONE 2011; 6(1): art.nr. e15943 (4 / 4.411)
Bolscher JGM, Oudhoff MJ, Nazmi K, Antos JM, Guimaraes CP, Spooner E, Haney EF, Garcia Vallejo JJ, Vogel HJ, Hof
W, Ploegh HL, Veerman ECI. Sortase A as a tool for high-yield histatin cyclization. FASEB J 2011; 25: 2650-2658 (5 /
6.515)
Bongaerts M, van de Bovenkamp JH, Morre SA, Manders ME, Heddema ER. Evaluation of the Siemens VERSANT «
CT/GC DNA 1.0 Assay (kPCR) for detection of Chlamydia trachomatis and Neisseria gonorrhoeae. J Microbiol Meth
2011; 87: 139-142 (2 / 2.018)
Boomsma MF, Garssen B, Beelen RHJ. Surgery-Induced Immunomodulation and the Importance of the Perioperative
Period. J Surg Oncol 2011; 103: 196 (4 / 2.428)
Bordes P, Cirinesi AM, Ummels R, Sala A, Sakr S, Bitter W, Genevaux P. SecB-like chaperone controls a toxin-antitoxin
stress-responsive system in Mycobacterium tuberculosis. P Natl Acad Sci USA 2011; 108: 8438-8443 (5 / 9.771)
Cascioferro A, Daleke MH, Ventura M, Dona V, Delogu G, Palu G, Bitter W, Manganelli R. Functional Dissection of the
PE Domain Responsible for Translocation of PE_PGRS33 across the Mycobacterial Cell Wall. PLoS ONE 2011; 6(11):
e27713 (4 / 4.411)
Chamberlain CS, Leiferman EM, Frisch KE, Wang SJ, Yang XP, van Rooijen N, Baer GS, Brickson SL, Vanderby R. The
influence of macrophage depletion on ligament healing. Connect Tissue Res 2011; 52: 203-211 (3 / 2.093)
Chang YJ, Kim HY, Albacker LA, Lee HH, Baumgarth N, Akira S, Savage PB, Endo S, Yamamura T, Maaskant J, Kitano
N, Singh A, Bhatt A, Besra GS, van den Elzen P, Appelmelk BJ, Franck RW, Chen GW, DeKruyff RH, Shimamura M,
Illarionov P, Umetsu DT. Influenza infection in suckling mice expands an NKT cell subset that protects against airway
hyperreactivity. J Clin Invest 2011; 121: 57-69 (5 / 14.152)
Chao J, Donham P, van Rooijen N, Wood JG, Gonzalez NC. Monocyte Chemoattractant Protein-1 Released from
Alveolar Macrophages Mediates the Systemic Inflammation of Acute Alveolar Hypoxia. Am J Resp Cell Mol 2011; 45:
53-61 (4 / 4.426)
Characiejus D, Jacobs JJL, Pasukoniene V, Kazlauskaite N, Danileviciute V, Mauricas M, den Otter W. Prediction of
Response in Cancer Immunotherapy. Anticancer Res 2011; 31: 639-647 (2 / 1.656)
Characiejus D, Pasukoniene V, Jacobs JJL, Eidukevicius R, Jankevicius F, Dobrovolskien N, Mauricas M, van Moorselaar
RJA, den Otter W. Prognostic Significance of Peripheral Blood CD8(high)CD57+Lymphocytes in Bladder Carcinoma
Patients After Intravesical IL-2. Anticancer Res 2011; 31: 699-703 (2 / 1.656)
Cheng CW, Duwaerts CC, van Rooijen N, Wintermeyer P, Mott S, Gregory SH. NK cells suppress experimental
cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism. J Hepatol 2011; 54: 746-752
(5 / 9.334)
Chow A, Lucas D, Hidalgo A, Mendez-Ferrer S, Hashimoto D, Scheiermann C, Battista M, Leboeuf M, Prophete C, van
Rooijen N, Tanaka M, Merad M, Frenette PS. Bone marrow CD169(+) macrophages promote the retention of
hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med 2011; 208: 261-271 (5 /
14.776)
Christerson L, de Vries HJ, Klint M, Herrmann B, Morre SA. Multilocus Sequence Typing of Urogenital Chlamydia
trachomatis From Patients With Different Degrees of Clinical Symptoms. Sex Transm Dis 2011; 38: 490-494 (3 / 3.268)
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Cobb BA, Rabinovich GA, van Kooijk Y. State of the union: glycobiology and immunology in the Canadian Rockies.
Glycobiology 2011; 21: 545-546 (3 / 3.791)
Cook PC, Aynsley SA, Turner JD, Jenkins GR, van Rooijen N, Leeto M, Brombacher F, Mountford AP. Multiple Helminth
Infection of the Skin Causes Lymphocyte Hypo-Responsiveness Mediated by Th2 Conditioning of Dermal Myeloid Cells.
PLoS Pathog 2011; 7 (3): e1001323 (5 / 9.079)
Cornet AD, Hofstra JJ, Vlaar AP, van den Boogaard FE, Roelofs JJ, van der Poll T, Levi M, Groeneveld ABJ, Schultz MJ.
Nebulized Anticoagulants Limit Coagulopathy But Not Inflammation in Pseudomonas Aeruginosa-Induced Pneumonia in
Rats. Shock 2011; 36: 417-423 (4 / 3.203)
Daleke MH, Cascioferro A, de Punder K, Ummels R, Abdallah AM, Wel N, Peters PJ, Luirink S, Manganelli R, Bitter W.
Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) Protein Domains Target LipY Lipases of Pathogenic Mycobacteria to the
Cell Surface via the ESX-5 Pathway. J Biol Chem 2011; 286: 19024-19034 (4 / 5.328)
de Greef JC, Wang J, Balog J, den Dunnen JT, Frants RR, Straasheijm KR, Aytekin C, van der Burg M, Duprez L,
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Driessen NN. Sugar caps of mycobacteria: virulence factors or decorative elements?. Vrije Universiteit Amsterdam,
11/22/2011. (Co-)promotores: CMJE Vandenbroucke-Grauls, BJ Appelmelk (cat A)
Karimi O. Immunogenetics of infection and inflammation of the urogenital and gastrointestinal tracts and probiotics.
Vrije Universiteit Amsterdam, 12/21/2011. (Co-)promotores: AS Peña, SA Morré, JBA Crusius (cat A)
Meenken C. Ocular Involvement in HIV infection and AIDS. Vrije Universiteit Amsterdam, 5/10/2011. (Co-)promotores:
PJ Ringens, SA Danner, G van den Horn(cat A)
Ouwehand K. The Skin Immune System: "The resourceful army of Langerhans cells". Vrije Universiteit Amsterdam,
1/4/2011. (Co-)promotores: RJ Scheper, S Gibbs, TD de Gruijl(cat A)
Quint KD. Urogenital and anal chlamydia trachomatis infections: a study into diagnostics, geno-epidemiology and the
association with cervical dysplasia. Vrije Universiteit Amsterdam, 5/26/2011. (Co-)promotores: CJLM Meijer, HJC de
Vries, SA Morré(cat B)
Sluijter BJR. Cutaneous melanoma; Predictors of patient survival and the potential of priming of the sentinel lymph
node. Vrije Universiteit Amsterdam, 5/27/2011. (Co-)promotores: RJ Scheper, PAM van Leeuwen, TD de Gruijl, MP
van der Tol (cat A)
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van der Veer WM. Cellular and Molecular Mechanisms in Hypertrophic Scar Formation: Potential Targets for Therapy.
Vrije Universiteit Amsterdam, 12/1/2011. (Co-)promotores: E Middelkoop, G Molema, FB Niessen(cat A)
van Gageldonk AB. Enhancing surveillance for control of respiratory infections in the Netherlands. Vrije Universiteit
Amsterdam, 11/24/2011. (Co-)promotores: FG Schellevis, van der Sande MAB(cat B)
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Dijkmans BAC. Van spalk tot slimme spuit. Het veranderend perspectief van de reumatologie. Ned Tijdschr Geneeskd
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Gordijn MS, Gemke RJBJ, Kaspers GJL, Walenkamp MJE. Bijnierschorsinsufficientie door glucocoritcoidgebruik in de
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Karagozoglu KH, Castelijns JA, Bloemena E, de Bree R, van der Waal I. Een vergrote lymfeklier in de hals:wat te
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snelle verwijzing. Ned Tijdschr Geneeskd 2011; 155: .
Lems WF, Kuipers EJ. Preventie van NSAID-gastropathie: het verschil tussen coxibs en PPI. Ned Tijdschr Geneeskd
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Meijer E, Janssen JJWM, Huisman C, Petersen EJ, Coenen JL, von dem Borne PA. Complicatieregistratie na
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Meijer E, Janssen JJWM, Huls G. HOVON 96: preventie en behandeling van ernstige graft-versus-hostziekte na
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Mostert S. Voortijdig verlaten van de behandeling van kinderkanker. Oncologie Up-to-date 2011; 2: 14.
Nolte JW, van der Waal I. Verrassende witte laesies. Ned Tijdschr Tandheelkd 2011; 118: 417-419.
Ossenkoppele GJ, Janssen JJWM, Posthuma EFM, Falkenburg JHF, Biemond BJ, Bos GMJ, Petersen EJ, Schattenberg
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myeloide leukemie namens de HOVON Leukemie Werkgroep. Ned T Hematologie 2011; 8: 237-247.
Rustemeyer T. Kruisreactiviteit bij corticosteroiden: nieuwe klinische en moleculaire indelingen. NTVa 2011; 11: 143144.
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Thunnissen FB, Smit EF, Nederlof PM, Dingemans AMC. EGFR-mutatie bij niet-kleincellig longcarcinoom. Behandeling
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van de Laar TJW. Acute hepatitis C bij HIVpositieve mannen die seks hebben met mannen: epidemiologie, diagnose
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van der Waal I. Witte wangen. Ned Tandartsenbl 2011; 66: 41.
van der Waal I. Zwelling van het tuber maxillare. Ned Tandartsenbl 2011; 66: 31.
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van der Waal I. Premaligne afwijkingen van het mondslijmvlies. Quality Practice Nascholingstijdschrift voor
van der Waal I. Pigmentaties. Tandartspraktijk 2011; 32: 21-34.
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Popular publications
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Assaraf YG, Jansen G. Grenzeloos onderzoek brengt oplossing nabij. Interview V-ICI visiting professor YG Assaraf
(Haifa, Isreal). Rondom Reuma 2011; 2: 18-21.
Gibbs S. Kunsthuid voor allergieonderzoek (promovendus Krista Ouwehand). De Telegraaf 2011.
Gibbs S. Allergieonderzoek straks niet meer op proefdieren (promovendus Krista Ouwehand). Metro 2011.
Gibbs S. Mens & lichaam: de beste pleister op de wond? Die wordt gemaakt van je eigen huidcellen. Quest 2011.
Krekel NMA, van den Tol MP. Trial: onderzoek naar echogeleid opereren. BVN 2011; 2: 24-25.
Krekel NMA, van den Tol MP. Echogeleid opereren loont. De Telegraaf - Bijlage Aandacht voor kanker 2011; 2: 8-9.
Krekel NMA, van den Tol MP. Onderzoek in de geest van Marian - Kennis en kunde ingezet voor echogeleide chirurgie.
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Krekel NMA, van den Tol MP. Mark Osinga schenkt echo-apparaat. En meer!. VUmc Cancer Center Nieuwsbrief 2011;
17: 12-13.
Rustemeyer T. Zonneallergie; 25 maart. De Telegraaf 2011.
Rustemeyer T. Ziekenhuizen zien explosie aan hooikoortsklachten; 28 april. De Volkskrant 2011.
Rustemeyer T. Zonneallergie en behandeling; 23 mei. RTL nieuws 2011.
Rustemeyer T. Effectieve thuisbehandeling tegen zonneallergie ontwikkeld, 25 mei. Trouw 2011.
van den Tol MP. Het wapen van Amsterdam. Pink 2011.
van den Tol MP. Echogeleid opereren borstkankerpatiënten. Zin magazine 2011 .
van der Waal I. Focale melanose van het palatum. Mondhygienisten Vademecum 2011; 9.
Dissertations
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Bartelds GM. Clinical implications of immunogenicity. Vrije Universiteit Amsterdam, 5/18/2011. (Co-)promotores: BAC
Dijkmans, LA Aarden, MT Nurmohamed, GJ Wilbink (cat B)
Biere SSAY. Evidence Based Minimally Invasive Surgery for Esophageal Cancer. Vrije Universiteit Amsterdam,
9/21/2011. (Co-)promotores: MA Cuesta, DL van der Peet (cat A)
Eijk IC. Modulation of cardiovascular risk factors and inflammation in rheumatic diseases. Vrije Universiteit
Amsterdam, 4/21/2011. (Co-)promotores: BAC Dijkmans, YM Smulders, MT Nurmohamed, MT Schaardenburg (cat A)
Graafland NM. Contemporary management of penile sqamous cell carcinoma. Vrije Universiteit Amsterdam,
1/7/2011. (Co-)promotores: S Horenblas (cat B)
Güler-Yüksel M. Inflammatory localized and generalized bone-loss in recent-onset rheumatoid arthritis. Vrije
Universiteit Amsterdam, 1/12/2011. (Co-)promotores: WF Lems, TWJ Huizinga, BAC Dijkmans (cat A)
Idema S. Improving Oncolytic Viral Therapy for Glioma. Vrije Universiteit Amsterdam, 6/10/2011. (Co-)promotores:
WP Vandertop, CMF Dirven, MLM Lamfers, VW van Beusechem (cat A)
Mendes RA. The keratocystic odontogenic tumor. Clinical behaviour and role of COX-2 in the biological pathways.
Vrije Universiteit Amsterdam, 4/29/2011. (Co-)promotores: I van der Waal, JFC Carvalho(cat A)
Palma DA. Stereotactic radiation therapy for stage I non-small cell lung cancer: outcomes in patients and populations.
Vrije Universiteit Amsterdam, 7/1/2011. (Co-)promotores: S Senan, BJ Slotman(cat A)
van Dijk FS. Osteogenesis Imperfecta: Clinical and Genetic Heterogeneity. Vrije Universiteit Amsterdam, 12/16/2011.
(Co-)promotores: EJ Meijers-Heijboer, G Pals(cat A)
van Nifterik KA. In vitro studies on radiation and temozolomide in human glioma. Vrije Universiteit Amsterdam,
11/16/2011. (Co-)promotores: BJ Slotman, P Sminia, LJA Stalpers, LJA Lafleur (cat A)
Vis M. Rheumatoid arthritis: Biologicals and Bone. Vrije Universiteit Amsterdam, 4/5/2011. (Co-)promotores: WF
Lems, BAC Dijkmans, AE Voskuyl, GJ Wolbink (cat A)
Vroling L. Circulating endothelial and progenitor cells during anti-angiogenic treatment in cancer patients. Vrije
Universiteit Amsterdam, 1/27/2011. (Co-)promotores: VWM van Hinsbergh, HMW Verheul, HJ Broxterman(cat A)
Program 5: Quality of life
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Aaronson NK, Taphoorn MJB, Heimans JJ, Postma TJ, Gundy C, Beute GN, Slotman BJ, Klein M. Compromised HealthRelated Quality of Life in Patients With Low-Grade Glioma. J Clin Oncol 2011; 29: 4430-4435. (5 / 18.97).
Aerts PDM, de Vries J, van der Steeg AFW, Roukema JA. The relationship between morbidity after axillary surgery and
long-term quality of life in breast cancer patients: The role of anxiety. EJSO-Eur J Surg Onc 2011; 37: 344-349. (4 /
2.772).
Andersson E, Ljotsson B, Smit F, Paxling B, Hedman E, Lindefors N, Andersson G, Ruck C. Cost-effectiveness of
internet-based cognitive behavior therapy for irritable bowel syndrome: results from a randomized controlled trial.
BMC Public Health 2011; 11: art.nr. 215. (4 / 2.364).
Biesma B, Wymenga ANM, Vincent AD, Dalesio O, Smit HJM, Stigt JA, Smit EF, van Felius CL, van Putten JWG, Slaets
JPJ, Groen HJM. Quality of life, geriatric assessment and survival in elderly patients with non-small-cell lung cancer
treated with carboplatin-gemcitabine or carboplatin-paclitaxel: NVALT-3 a phase III study. Ann Oncol 2011; 22: 15201527. (4 / 6.452).
Breteler JK, Oudhoff JP, Munster JM, Aarnoudse JG, van Steenbergen JE, Beaujean DJMA. Risks, trust and knowledge:
determinants of pregnant women's decisions regarding participation in a future Q fever screening and treatment
program during a large epidemic in The Netherlands. Prenatal Diag 2011; 31: 814-820. (3 / 2.152).
de Bruijn MJ, ten Bosch L, Kuik DJ, Langendijk JA, Leemans CR, Verdonck-de Leeuw IM. Artificial neural network
analysis to assess hypernasality in patients treated for oral or oropharyngeal cancer. Logop Phoniatr Voco 2011; 36:
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de Ruiter MB, Reneman L, Boogerd W, Veltman DJ, van Dam FSAM, Nederveen AJ, Boven E, Schagen SB. Cerebral
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de Vos J, Jansen AM, Menko FH, van Asperen CJ, Stiggelbout AM, Tibben A. Family communication matters: The
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de Vos J, Menko FH, Jansen AM, van Asperen CJ, Stiggelbout AM, Tibben A. A whisper-game perspective on the family
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de Vos J, Oosterwijk JC, Gomez-Garcia E, Menko FH, Jansen AM, Stoel RD, van Asperen CJ, Tibben A, Stiggelbout AM.
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de Vos J, Stiggelbout AM, Oosterwijk J, Gomez-Garcia E, Menko FH, Collee JM, van Asperen CJ, Tibben A. A
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Mortality, Inflammation and Quality of Life. Contrib Nephrol 2011; 168: 39-52. (2 / 1.274).
Engelen V, Koopman HM, Detmar SB, Raat H, de Wetering MDV, Brons P, Anninga JK, Abbink FCH, Grootenhuis MA.
Health-Related Quality of Life After Completion of Successful Treatment for Childhood Cancer. Pediatr Blood Cancer
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Gaultney JG, Sanhueza E, Janssen JJWM, Redekop WK, Uyl-de Groot CA. Application of cost-effectiveness analysis to
demonstrate the potential value of companion diagnostics in chronic myeloid leukemia. Pharmacogenomics 2011; 12:
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Gehring K, Aaronson NK, Taphoorn MJB, Sitskoorn MM. A description of a cognitive rehabilitation programme
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1.772).
Gordijn MS, Cremers EMP, Kaspers GJL, Gemke RJBJ. Fatigue in children: reliability and validity of the Dutch
PedsQL(TM) Multidimensional Fatigue Scale. Qual Life Res 2011; 20: 1103-1108. (3 / 1.958).
Hagedoorn M, Dagan M, Puterman E, Hoff C, Meijerink WJHJ, DeLongis A, Sanderman R. Relationship satisfaction in
couples confronted with colorectal cancer: the interplay of past and current spousal support. J Behav Med 2011; 34:
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Harms K, Post WJ, van de Laan KT, van den Hoogen FJA, Eerenstein SEJ, van Laan BFAM. A prospective randomized
multicenter clinical trial of the Provox2 and Groningen Ultra Low Resistance voice prostheses in the rehabilitation of
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Henneman L, Timmermans DRM, Bouwman CM, Cornel MC, Meijers-Heijboer EJ. 'A low risk is still a risk': Exploring
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van Litsenburg RRL, Uyl-de Groot CA, Raat H, Kaspers GJL, Gemke RJBJ. Cost-Effectiveness of Treatment of
Childhood Acute Lymphoblastic Leukemia With Chemotherapy Only: The Influence of New Medication and Diagnostic
Technology. Pediatr Blood Cancer 2011; 57: 1005-1010. (3 / 1.948).
van Tuyl LHD, Smolen JS, Wells GA, Scholte-Voshaar M, Hoogland W, Boers M. Patient Perspective on Remission in
Rheumatoid Arthritis. J Rheumatol 2011; 38: 1735-1738. (3 / 3.551).
Verelst SGR, Termorshuizen F, Uyl-de Groot CA, Schaafsma MR, Ammerlaan AHM, Wittebol S, Sinnige HAM, Zweegman
S, Kooy MV, van der Griend R, Lokhorst HM, Sonneveld P, Wijermans PW. Effect of thalidomide with melphalan and
prednisone on health-related quality of life (HRQoL) in elderly patients with newly diagnosed multiple myeloma: a
prospective analysis in a randomized trial. Ann Hematol 2011; 90: 1427-1439. (2 / 2.688).
Vermeulen E, Schmidt MK, Cornel MC, Knoppers BM, van Leeuwen FE, Aaronson NK. Connective tissue: Cancer
patients' attitudes towards medical research using excised (tumour) tissue. BioSocieties 2011; 6: 466-486. (4 / 1.907).
Waagemans ML, van Nieuwenhuizen D, Dijkstra M, Wumkes M, Dirven CMF, Leenstra S, Reijneveld JC, Klein M,
Stalpers LJA. Long-term Impact of Cognitive Deficits and Epilepsy on Quality of Life in Patients With Low-Grade
Meningiomas. Neurosurgery 2011; 69: 72-78. (5 / 3.298).
Wassenberg MWM, Kluijtmans JAJW, Bosboom RW, Buiting AGM, van Elzakker EPM, Melchers WJG, Thijsen SFT,
Troelstra A, Vandenbroucke-Grauls CMJE, Visser CE, Voss A, Wolffs PFG, Wulf MWH, van Zwet AA, de Wit GA, Bonten
MJM. Rapid diagnostic testing of methicillin-resistant Staphylococcus aureus carriage at different anatomical sites:
costs and benefits of less extensive screening regimens. Clin Microbiol Infec 2011; 17: 1704-1710. (4 / 4.784).
Wiering B, Oyen WJG, Adang EMM, van der Sijp JRM, Roumen RM, de Jong KP, Ruers TJM, Krabbe PFM. Long-term
global quality of life in patients treated for colorectal liver metastases. Brit J Surg 2011; 98: 565-571. (5 / 4.444).
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5.
de Vries MC, Houtlosser M, Wit JM, Engberts DP, Bresters D, Kaspers GJL, van Leeuwen E. Ethical issues at the
interface of clinical care and research practice in pediatric oncology: a narrative review of parents' and physicians'
experiences. BMC Medical Ethics 2011; 12: 18.
Gehring K, Aaronson NK, Gundy C, Taphoorn MJB, Sitskoorn MM. Predictors of Neuropsychological Improvement
Following Cognitive Rehabilitation in Patients with Gliomas. J Int Neuropsych Soc 2011; 17: 256-266.
Martinelli F, Quinten C, Maringwa JT, Coens C, Vercauteren J, Cleeland CS, Flechtner H, Gotay C, Greimel E, King M,
Mendoza T, Osoba D, Reeve BB, Ringash J, Koch J, Shi QL, Taphoorn MJ, Weis J, Bottomley A. Examining the
relationships among health-related quality-of-life indicators in cancer patients participating in clinical trials: a pooled
study of baseline EORTC QLQ-C30 data. Expert review of pharmacoeconomics & outcomes research 2011; 11: 587-599.
van Tuyl HD, Scholte-Voshaar M. Patientenparticipatie in wetenschappelijk onderzoek. Ned Tijdschr Geneeskd 2011;
30-31: A3501.
Vissers KCP, Besse K, Wagemans M, Zuurmond WWA, Giezeman MM, Lataster A, Mekhail N, Burton AW, van Kleef M,
Huygen F. Pain in Patients with Cancer. Pain Practice 2011; 11: 453-475.
61
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Geleijn E, Smeets C, Vrijman M, Kron D, Boven E, Stuiver M. Cytofys, behoud van kracht en uithoudingsvermogen
tijdens chemotherapie. Ned Tijdschr Oncol 2011; 8: 80-86.
van der Linden HM, Giesbers J, van Zuureen FJ, Verdonck-de Leeuw IM, Kleverlaan N. Kinderen met een ouder met
kanker: lotgenotencontact via internet. Tijdschrift Psychosociale Oncologie 2011; 19: 20-21.
van Dijk-Lokkart A, Braam KI. Quality of Life in Motion: een gecombineerd fysiek en psychosociaal
trainingsprogramma voor kinderen met kanker. Nederlands Tijdschrift voor Behavioral Medicine 2011; 23: 18-21.
Verdonck-de Leeuw IM, de Haes H. Organisatie van psychosociale zorg bij patienten met kanker. Kanker Breed 2011;
1: 6-10.
Popular publications
1.
Mostert S. Indonesie: voorlichtingsprogramma werpt vruchten af. Attent 2011; 1: 23.
Dissertations
1.
2.
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Knols RHW. Physical exercise in patients with haematological malignancies. Vrije Universiteit Amsterdam, 5/16/2011.
(Co-)promotores: NK Aaronson, D Ueberhart, E de Bruin (cat B)
Hoopman R. Quality of life assessment in Turkish and Moroccan cancer patients in the Netherlands. Vrije Universiteit
Amsterdam, 1/28/2011. (Co-)promotores: NK Aaronson, CB Terwee (cat B)
Appendix 5: Indicators of esteem
Appendix 5. Indicators of esteem
In this appendix an overview is given of the memberships of editorial boards, (inter)national functions, lectures given and obtained
awards. In addition, newly obtained grants are listed to show the recruitment capacity of CCA/V-ICI, and news items are shown.
Memberships of editorial boards
Associate
Journal
Ang CM
• Nederlands Tijdschrift voor Medische Microbiologie
Appelmelk BJ
• Innate Immunity
Bitter W
• Microbiology SGM
• MicrobiologyOpen
Boers M
•
•
•
•
•
Braakhuis BJM
• The Open Pathology Journal
Brakenhoff RH
•
•
•
•
Broxterman HJ
• Drug Resistance Updates
Castelijns JA
• European Radiology
• American Journal of Neuroradiology
De Bree R
• European Archives of Otorhinolaryngology
• The Open Otorhinolaryngology Journal
• Oral Oncology
• Nederlands Tijdschrift voor Oncologie
De Winter JP
• The Open Genomics Journal
Dekker J
• International Journal of Behavioural Medicine
Hensen EF
• WikiNO website, Online database voor evidence-based KNO geneeskunde, Onder auspiciën van de
Nederlandse vereniging voor keel-, neus-, en oorheelkunde
Hoekstra OS
• The Oncologist
Jansen G
• The Open Arthritis Journal
Jimenez CR
• Journal of Proteomics
• Molecular and Cellular Proteomics
• Proteomics
Joenje H
•
•
•
•
Kaspers GJL
• Journal of Oncology and Expert Reviews of Anticancer Therapy
Kluytmans JAJW
• Journal of Infectious Diseases
• Antimicrobial Resistance and Infection Control
Lammertsma AA
•
•
•
•
•
•
•
•
Arthritis and Rheumatism
Letter to the Editor in Rheumatology
Journal for Clinical Epidemiology
Annals of Rheumatic Diseases
Journal of Rheumatology
International Head and Neck Scientific group
Clinical Cancer Research
Current Cancer Therapy Reviews
Oral Oncology
Anemia
Cellular Oncology
Familial Cancer
The Open Genomics Journal
Molecular Imaging and Biology
Nuklearmedizin
Journal of Cerebral Blood Flow and Metabolism
European Journal of Nuclear Medicine
Current Medical Imaging Reviews
BMC Medical Physics
Medical Physics
The International Journal of Molecular Imaging
63
Associate
Journal
Leemans CR
•
•
•
•
•
•
•
•
•
•
•
Menko FH
• Familial Cancer
Ossenkoppele GJ
• Nederlands Tijdschrift voor Hematologie
Peters GJ
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
Rustemeyer T
• Contact Dermatitis
• Dermatologie in Beruf und Umwelt
• Nederlands Tijdschrift voor Allergologie
Savelkoul PHM
• Clinical Microbiology and Infection
Schuurhuis GJ
• Open Hematology Journal
• International Scholarly Research Network Hematology
Senan S
• Radiation Oncology
• The Oncologist
• Journal of Thoracic Disease
Slotman BJ
• Journal of Radiosurgery and Stereotactic Body Radiotherapy
• J Radiotion Oncology
Stoof TJ
• Allergie Actueel
• Nederlands Tijdschrift voor Dermatologie en Venereologie
Taphoorn MJB
• Expert Review Pharmacoeconomics Outcomes
• Neuro-Oncology
Van Beusechem VW
• Human Gene Therapy
• Genetics Research International
Van Bodegraven A
• Journal of Crohns’ and Colitis
Van de Vliet H
• ISRN Immunology
Van der Waal I
•
•
•
•
64
Hoofd-hals Journaal (Head and Neck Journal of the NWHHT)
Nederlands Tijdschrift voor Keel-Neus-Oorheelkunde (Netherlands Journal of Otorhinolaryngology)
European Archives of Oto-Rhino-Laryngology Head and Neck
Oral Oncology
Head & Neck
Oral Diseases
Surgical Oncology
Italian Journal of Maxillofacial Surgery
Acta Otorrinolaringología Española
Acta Otorhinolaryngoiatrica Italica
Head and Neck Cancer Section of Frontiers in Oncology (Associate Editor)
European Journal of Cancer
Annals of Oncology
Journal of Chemotherapy
Clinical Colorectal Cancer
Cancer Chemotherapy and Pharmacology
International Journal of Oncology
Cancer Therapy
Journal of Pharmacology and Toxicology
Journal of Epithelial Biology and Pharmacology
Gastrointestinal Cancer Reviews
Chemotherapy Research and Practice
World Journal of Gastrointestinal Oncology
World Journal of Gastrointestinal Pharmacology and Therapeutics
Journal of Chinese Clinical Medicine
Chinese Journal of Clinicians
World Journal of Pharmacology
Nucleosides, Nucleotides and Nucleic Acids
World Journal of Clinical Oncology
American Journal of Cancer research
The Open Lung Cancer Journal
Journal of Cancer Research and Treatment
ACTA Stomatologica Croatica
European Journal of Cancer
Padjadjaran Journal of Dentistry
Medicina Oral
Associate
Journal
•
•
•
•
•
•
•
•
Oral and Maxillofacial Surgery
Oral Health & Preventive Dentistry
Oral Oncology
Revista de Odontologia da Universidade de São Paolo (Journal of Dentistry, University of São Paolo)
STOMA
Nederlands Tijdschrift voor Geneeskunde
Journal of Stomatological Investigation
Minerva Stomatologica
Van Moorselaar RJA
• Prostaat. Nl
Van Schaardenburg D
• Arthritis & Rheumatism
• Farmacotherapeutisch Kompas
• World Journal of Clinical Oncology
• Voice-, Speech and Language Pathology
Verheul H
• The Oncologist
• Current Angiogenesis
• Angiogenese Journaal
Voskuyl AE
• Clinical Rheumatology
Windhorst AD
• Journal of Labelled Compounds & Radiopharmaceuticals
• Current Radiopharmaceuticals
65
(Inter)national functions
Associate
Function
Abbink FCH
Member
• DCOG protocol Committee CML
• DCOG committee supportive care
Ang CW
Member
• Committee on sharing of knowledge Dutch Society for
Medical Microbiology
Appelmelk BJ
Councelor
• Microbiology, The International endotoxin and innate
immunity society
Bitter W
Member
• Wetenschapscommissie Nederlandse vereniging voor
Medische Microbiologie (NvMM)
Boellaard R
Member
• Physics committee European Association of Nuclear
Medicine (EANM)
• Scientific advisory board European Association of Nuclear
Medicine Research Ltd (EARL)
• Imaging workgroup European Organisation of Research
and Treatment of Cancer (EORTC)
• Imaging group Netherlands Hematology (HOVON)
• Scientific committee MIRO 2012 (joint ESTRO/EANM
meeting)
• Educational committee “Medical Imaging” responsible for
organising the educational program for clinical physicists
Radiology and/or Nuclear Medicine (2009-present), Dutch
Society of Clinical Physics
• Quantitative Imaging Biomarkers Alliance (QIBA) 2008present, Radiological Society of Northern America
(RSNA).
• PET/CT committee and member of the SUV and ROI
subcommittees, Radiological Society of Northern America
(RSNA)
• Quantitative Imaging Biomarkers Alliance (QIBA) 2008present. Member of the UPICT writing committee,
Radiological Society of Northern America (RSNA)
Braakhuis BJM
Member
• Research Commitee International Academy of Oral
Oncology
Bretschneider J
Projectleader
• Apple Distinguished Educator
• iTunes U VUmc
Castelijns JA
Member
•
•
•
•
•
•
Chair
• Head and
Radiology)
De Bree R
Member
• Steering committee Research Nederlandse Werkgroep
Hoofd-halstumoren (NWHHT)
De Gruijl TD
Member
• Grant Review committee, Melanoma Research Alliance
Chair
• Nederlandse Werkgroep Tumor Immunologie
Associate Professor
• Physiotherapy – Psychological aspects of rehabilitation,
Faculty of Sports and Health Sciences, University of
Jyväskylä, Finland
President Elect and member
• Governing Council International Society of Behavioral
Medicine
Board member
• Netherlands Behavioral Medicine Federation
Dekker J
66
Organisation
Concilium Radiologicum
MSRC
Radiological Society of Northern America
American Society of Neuroradiology
American Society of Head and Neck Radiology
Executive Com. European Society of Head and Neck
Radiology
• European Society of Neuroradiology
• Neuro Section, NVvR (Dutch Society of Radiology)
Neck
Section,
NVvR
(Dutch
Society
of
Associate
Function
Organisation
Member
• Committee on Medical Technology Assessment, Health
Council of the Netherlands (Gezondheidsraad)
• International Advisory Board, Behaviour Change
Technique Taxonomy Project
Program committee
• Nederlandse vereniging voor Experimentele Dermatologie
Member
• Dutch Program for Tissue Engineering Consortium
Contact person VUmc
• Topsector Life Sciences and Health - Roadmap
Regenerative Medicine
Work Package Leader
• EU integrated FP6 project: Sens-it-iv
Heimans JJ
Member
• European Federation of Neurological Societies (EFNS)
neuro-oncology group
• European Association for Neuro-Oncology (EANO)
• Dutch Neuro-Oncology Group (LWNO)
• Society for Neuro-Oncology (SNO)
• National Health Council The Netherlands
(Gezondheidsraad)
Hoekstra OS
Member
•
•
•
•
Issa D
Member
• NIV (Nederlandse internisten vereeniging)
• NVVH (Nederlandse vereniging voor hematologie)
• EHA (European Hematology association)
Janssen, JJWM
Member
•
•
•
•
•
Jimenez CR
Coördinator
• Netherlands Proteomics Platform
General Council Member
• European Proteomics Association (EuPA)
Coórdinator
• Colon proteomics team International Cancer Biomarker
Consortium
Secretary
• Proteomics werkgroep, Ned. Ver. Klin. Chemie
WP-co-leader
• EU kp7 project MEFOPA
Member
•
•
•
•
•
•
•
•
Joenje H
Member
• Scientific Advisory Board Fanconi Anemia Research Fund,
Inc., Eugene, Oregon, USA.
Kaspers GJL
Chairman
•
•
•
Gibbs S
Exec Committee EORTC imaging group EORTC
SNM PET Center of Excellence board Soc Nucl Medicine
Imaging group Netherlands Hematology (HOVON)
Quantitative Imaging Biomarkers Alliance (QIBA) 2008present Radiological Society of Northern America (RSNA).
• UK PET Research Steering Committee
• CBO richtlijn commissie NSCLC
American Society of Hematology
HOVON Stem cell Transplantation Working Party
Dutch Society of Hematology
European Blood and Marrow Transplantation group (EBMT)
Nederlandse Internisten Vereniging (Dutch Internist
Society)
• European Hematology Association
•
•
•
EU kp7 project AngioTOX
WP1 CTMM-Airforce consortium
WPB CTMM-DeCoDe consortium
Human Proteome Organisation
American Society for Mass Spectrometry
American Society for Biochemistry and Molecular Biology
Dutch Society for Biochemistry and Molecular Biology
Dutch Society for Mass spectrometry
VUmc Onderzoek Naar Kinderkanker (VONK)
Disease Committee Myeloid Malignancies, DCOG
Protocol committees Relapsed AML 1999/2001 and
2010/01 and pediatric APL, DCOG
Working Group “shared care”, DCOG
Stichting VUmc Kinderstad”, 2011 onwards
AML Relapse Working Group, International BFM Study
67
Associate
Function
Organisation
Group
Program co-leader
• “Quality of Life” of CCA/V-ICI, VU University Medical
Center, Amsterdam
Co-Chair
• IKNL – Werkgroep Kindertumoren Amsterdam
Member
• Supervisory Board SKION = Dutch Childhood Oncology
Group (DCOG)
• Protocol committee ALL-10 and AML2007 (DB-AML01),
DCOG
• Scientific Committee, DCOG
• LAD, NVK, NVvO, KNMG; AACR, ASH, EHA, SIOP
International coordinator
• I-BFM-SG Phase III studies “Relapsed AML 2001/01” and
“Relapsed AML 2010/01”
• Phase III study on Pediatric APL (ICC APL 01)
Principal investigator
• I-BFM-SG and ITCC study 021 “Bortezomib in childhood
relapsed and
• refractory ALL”
Invited member
• Scientific Committee “Lymphoid Neoplasia” of the
American Society of Hematology, 2008-2012 (2010 vicechairman, 2011 chairman)
Member
•
•
•
•
•
European co-ordinator
• International trial on bullous pemphigoid; HTA grant UK
Scientific Expert
• Medische adviesraad lichen planus vereniging
Klein M
Member
• writing committee, Brain Tumour Group EORTC
• steering committee Primary Central Nervous System
Lymphoma Collaborative Group
• Clinical Trials Awards & Advisory Committee on study
“Temozolomide as adjuvant treatment in anaplastic
astrocytoma”, Cancer Research United Kingdom
• Clinical Trials Awards & Advisory Committee, French
National Cancer Institute
• Nederlandse Vereniging voor Neuropsychologie
• Nederlands-Belgische Vereniging voor Experimentele en
Klinische Neurowetenschappen
• Landelijke Werkgroep Neuropsychologie bij Epilepsie
• Landelijke Werkgroep Functionele Neurochirurgie
Kluytmans JAJW
Chair
•
•
•
•
•
Member
•
•
•
•
Kirtschig G
Bestuur Werkgroep Infectiepreventie
Foundation Werkgroep Infectiepreventie (WIP)
Infectiecommissie Amphia Ziekenhuis, Breda
SWAB commissie eradicatie van dragerschap met MRSA
NVMM commissie laboratorium detectie van MRSA en van
BRMO
• Faculty: European course on hospital epidemiology and
infection control
•
•
•
•
•
•
68
UK Dermatology Clinical Trials Network
EADV / EDF task force
Werkgroep lichen sclerosus en lichen planus
Nederlandse Vereniging voor Vulva Pathologie
Editorial Advisory Board of IJDVL
Amphia Academy Infectious Disease Foundation
Infectiecommissie Verpleeghuis Elisabeth, Breda
Raad van Qualiteit, Amphia Ziekenhuis, Breda
Commissie wetenschap bevordering Amphia Ziekenhuis,
Breda
Adviescommissie PREZIES
Concilium Microbiologicum Medische Microbiologie
Gezondheidsraad gebruik van antibiotica in de
veehouderij
Organisatie Boerhaave nascholing infectieziekten
Publications Committee van de SHEA
Scientific Advisory Committee van ESCMID
Associate
Function
Organisation
•
•
•
•
European Advisory Board 3M
International Advisory Board Pfizer
Zien
European expert group on MRSA van het ECDC
Organizer
• ASM conference Emerging Technologies of Medical
Importance for the Diagnosis of Infectious Diseases and
the Detection of Pathogenic Microbes
Member
• Landelijke Werkgroep Hemoglobinopathie Behandelaren
• Werkgroep Benigne Hematologie van de sectie
kinderoncologie-hematologie van de NVK
• Adviescommissie Neonatale Screening (ANS SIKK) NVK
• Werkgroep Sikkelcelanemie-Netwerk Kindergeneeskunde
regio Amsterdam
• Protocol Commissie Aplastische Anemie van de
ziektecommissie beenmergfalen DCOG
• IKA stamcelwerkgroep
• Landelijke pediatrische werkgroep trombose en stroke
Chair
• Protocol Commissie Retinoblastoom van de
ziektecommissie CZS DCOG (Dutch Childhood Oncology
Group)
Lammertsma AA
Member
•
•
•
•
•
•
•
Leemans CR
President
• Dutch Head and Neck Oncology Cooperative Group
(NWHHT)
• Netherlands Society for Otorhinolaryngology and CervicoFacial Surgery
Member
•
•
•
•
Kors WA
•
•
•
•
•
Advisory Board, Tijdschrift voor Nucleaire Geneeskunde
IFAC BIOMED Technical Committee, IFAC BIOMED
Scientific program committee, Brain 2011
Scientific steering committee, EMIM 2011
Management committee, PET-MRI FP7 COST action
Healthcare PET/CT Focus Group Europe, Philips
Steering committee Dutch Imaging Hub, Roche
Netherlands Society of Oncology
Concilium Oto-rhino-laryngologicum in the Netherlands
American Head and Neck Society
American Academy of Otolaryngology-Head and Neck
Surgery
British Association of Head and Neck Oncologists
European Rhinological Society
Collegium Oto-rhino-laryngologicum Amicitiae Sacrum
(CORLAS)
European Salivary Gland Society (ESGS)
Spanish Society of Otorhinolaryngology-Head and Neck
Surgery (Sociedad Española de Otorrinolaringología y
Pathología Cérvico-Facial; SEORL-PCF)
Chairman
• Subcommittee Surgery Head and Neck Cancer
Cooperative Group of the European Organization for
Research and Treatment of Cancer (EORTC)
Secretary
• Working Party Head and Neck Surgery of the Netherlands
Society for Otorhinolaryngology and Cervico-Facial
Surgery
Founding Fellow
• International Academy of Oral Oncology
Lems W
Organizer and Chairman
• ASBMR Working Group on Rheumatic Diseases, ASBMR,
19th of September, San Diego
Molthoff CFM
Coordinator
• HRRT (animal) PET scanner
Member
• Dutch working group on “Advanced Drug Delivery/Drug
Targeting”
• The Netherlands Society of Immunology
• The Netherlands Institute of Biology
Member
• SIOP PODC Abandonment of Treatment Working Group
Mostert S
69
Associate
Function
Ossenkoppele GJ
Chairman
• WP HOVON
• Leukemia WP European Leukemia Net
Boardmember
• European Leukemia Net
• Scientific Board KWF
• Dutch Society of Hematology
Member
• EHA Educational Committee (Hnet)
Member
• European Organization for Research and treatment of
Cancer
• EORTC General Assembly
• EORTC-Translational Research Advisory Committee
(TRAC)
• American Association for Cancer Research
• Scientific committee Winter EORTC-PAMMmeeting,
Toulouse, France
• Scientific committee Puridine and Pyrimidine Metabolism
in Man, Tokyo, Japan
• International Society on Nucleosides, Nucleotides and
Nucleic Acids (IS3NA)
Chairman
• EORTC Pharmacology and Molecular Mechanisms Group
Vice-chairman
• EORTC Drug Discovery Committee NCI compounds task
force
Secretary
• Purine and Pyrimidine Society (PPS)
Pham TV
Member
•
•
•
•
Piersma SR
Member
•
•
•
•
Pieters-van den Bos IC
Member
• ESR (European Society of Radiology)
• NVvR (Dutch Society of Radiology)
• Section of Abdominal Imaging, NVvR (Dutch Society of
Radiology)
• KNMG (Royal Netherlands Medical Association)
• RNSA (Radiological Society of Northern America)
Postma TJ
Member
• European Federation of Neurological Societies (EFNS)
neuro-oncology group
• Steering committee, Ci-Perinoms study (European
collaboration project on the assessment of
chemotherapy-induced peripheral neuropathy
Reijneveld JC
Member
• steering committee member, Brain Tumour Group EORTC
Chair
Board Member
• European Environmental and Contact Dermatitis Research
Group (EECDRG)
• Bestuur en Raad van Toezicht van de Stichting Nationaal
Huidfonds
• Bij- en Nascholingscommissie van de Nederlandse
Vereniging voor Dermatologie en Venereologie
• Nederlandse Vereniging voor Allergologie
• European Prevention of Occupational Skin Diseases
(EPOS)
Peters GJ
Rustemeyer T
70
Organisation
The International Society for Computational Biology
The International Association for Pattern Recognition
Human Proteome Organisation
Dutch Society for Pattern Recognition and Image
Processing
• Netherlands Proteomics Platform
American Society for Mass Spectrometry
Netherlands Proteomics Platform
Dutch Society for Biochemistry and Molecular Biology
Dutch Society for Mass spectrometry
Associate
Function
Organisation
• Stichting Milieu- en Arbeidsdermatologie
Savelkoul PHM
Schuurhuis GJ
Senan S
Slotman BJ
Member
• Domeingroep Allergologie en Contactdermatosen van de
Nederlandse vereniging voor Dermatologie en
Venereologie
• European Surveillance System on Contact Allergens
(ESSCA)
• Richtlijn “Lichen sclerosus” van de Nederlandse
vereniging voor Dermatologie en Venereologie en
Nederlandse Vereiniging voor Allergologie
• Werkgroep Allergische Beroepsziekten Amsterdam &
Omgeving
• Werkgroep Beroepsgebonden Huid- en Longklachten van
het VUmc, AMC, OLVG
Scientific Expert
• EU commission group on “Risk assessment of consumer
products’’
• Ministerie voor Volksgezondheid, Welzijn en Sport (VWS),
• Voedsel en Waren Autoriteit (VWA),
• Rijksinstituut voor Volksgezondheid en Milieu (RIVM)
Participant
• EU integrated FP6 project: Sens-it-iv
Chair
• Richtlijn “Contacteczeem” van de Nederlandse
vereniging voor Dermatologie en Venereologie en
Nederlandse Vereiniging voor Allergologie
• PMS cosmetica - Nederlandse Vereniging voor
Dermatologie en Venereologie
• CESES program van het Ministerie voor Volksgezondheid,
Welzijn en Sport (VWS), Voedsel en Waren Autoriteit
(VWA) en Rijksinstituut voor Volksgezondheid en Milieu
(RIVM)
Member
• Scientific Affairs Subcommittee (SAS), European
Study Group on Molecular Diagnostics (ESCMID)
• Commissie Nascholing, Dutch Society of Microbiology
(NvvM)
• Commissie Wetenschap van de Nederlandse Vereniging
voor Microbiologie, Dutch Society of Microbiology (NvvM)
• ESCMID European Study Group on Epidemiological Markers
(ESGEM)
• Concilium opleiding Medisch Microbiologisch
Onderzoeker MMO
• Concilium opleiding MMM, NVMM, Dutch Society of
Medical Microbiology (NVMM)
• Nederlandse Werkgroep Klinische Virologie, Dutch
Society of Medical Microbiology (NVMM)
• Werkgroep Moleculaire Diagnostiek Infectieziekten
Dutch Society of Medical Microbiology (NVMM)
Chair
• Vereniging voor Moleculair Diagnostici in de
Gezondheidszorg
Chair
• The international working party flowcytometric
assessment of minimal residual disease in acute myeloid
leukemia
Member
• European LeukemiaNet
Member
• Faculty member for Chest Tumors, European Society for
Medical Oncology
• Foundation Council European Thoracic Oncology Platform
• Honorary member, Belgische Vereniging voor
Radiotherapie en Oncologie
• International Advisory Panel, Cancer Research UK Clinical
Trials Awards and Advisory Committee
• CT Screening Task Force, International Association for the
Study of Lung Cancer,
Board of key opinion leaders
• Italian Association of Thoracic Oncology
Member
• Accreditation committee, American Radium Society
71
Associate
Function
Organisation
• ISRS Congfress Meeting & Scientific Committee Toronto
2013
Sminia P
Starink TM
Stoof TJ
Taphoorn MJB
Program Director
• Novalis Circle Meetings
Secretary-treasurer
• Dutch Society for Radiobiology (NVRB) & Board Member
Dutch Commission on Radiation Dosimetry (NCS)
Board member
• Dutch Commission on Radiation Dosimetry (NCS)
Scientific Committee
member
• The International Congress of Radiation Research (ICRR),
Warsaw, Poland, August 28 – September 1, 2011
Organizing Committee
• International meeting of the Dutch Society for
Radiobiology (NVRB), Noordwijkerhout, April 19-20, 2012
Board Member
• International Society of Dermatopathology
• Nederlandse Werkgroep voor Dermatopathologie
Member
• Concilium Dermatologicum et Venereologicum
• Medische Specialisten Registratie Commissie
Member
• Werkgroep Vulvapathologie van de Stichting Onderwijs
Oncologische Gynaecologie
• Nederlandse Vereniging voor Vulva Pathologie
• Nederlandse Werkgroep voor Dermatopathologie
• Medical advisory board PVN
Medical advisor
• Psoriasis Vereniging Nederland (PVN)
Member
•
•
•
•
•
•
•
•
•
•
van Montfrans C
Van Beusechem VW
Van der Horst-Bruinsma IE
Van der Laken J
72
Dutch Neuro-Oncology Group (LWNO)
Society for Neuro-Oncology (SNO)
European Association of Neuro-Oncology (EANO)
European Society for Medical Oncology (ESMO)
educational committee for Neuro-Oncology of the
European Society for Medical Oncology (ESMO)
International Society for Quality of Life Research
(ISOQOL)
EORTC Brain Tumour Group
EORTC Quality of Life Group
American Academy of Neurology (AAN)
American Neurological Association (ANA)
Chair
• Netherlands Society for Neurology
Board member
• Dutch Society of Dermatology and Venereology
Member
• European society of Dermatology and venereology
Boardmember
• Netherlands Society of Gene and Cell Therapy
Member
• Expert group on Advanced Therapy Medicinal Products,
Medicine Evaluation Board (CBG)
Member
•
•
•
•
Chair
• Commissie “Rode Loper” VUmc, coördinatiegroep
verwijzers
• Werkgroep “Beweegdag Reumapatiënten Amsterdam
• Landelijke werkgroep Patient Partners
• Bestuur Netherlands Rheumatoid Arthritis Surgical Society
(NERASS)
Vice-chair
• Dagelijks Bestuur Stafconvent VUmc
Committee member
• National working group REUS (Rheumatology Ultrasound)
Commissie wetenschappelijke stages VICI
NIAZ accreditatiecommissie
HASVU: overleg huisartsen-medisch specialisten
Werkgroep patiëntenzorg samenwerking VU-JBI
reumatologie
• Bestuur GENetica Research (GENRA) Amsterdam
• Stuurgroep ziekenhuisverplaatste zorg VUmc
Associate
Function
Organisation
Member
• Selected as one of 40 European Rheumatologists for the
European Leadership Series. This is a three year
programme for talented young rheumatologists with
promising research lines to form a european network and
to further develop leadership qualities. First meeting was
held in Amsterdam, 9-10 december 2011
Van der Sar AM
Scientific Advisory Board
• Vertebrate Antibodies, UK
Van der Vliet JJ
Member
• Organizing committee annual Lunteren educational
symposium dutch immunology association (NVVI)
Van der Waal I
Board member
• Centraal College van de Nederlandse Maatschappij tot
bevordering der Tandheelkunde
• Consilium Chirurgicum Oris
Expert
• UICC Telepathology Consultation Center for odontogenic
tissue of the International Union Against Cancer (UICC)
Register of External
Evaluation Experts
• Hellenic Quality Assurance Agency for Higher Education
(HQAA), Athene, Griekenland
Chairman Certificate
Committee
• European Association of Oral Medicine
Board member
• DCOG LATER-Research Steering Committee
M ember
• DCOG-LATER taskforce
Member
• European Society of Pediatric Infectious Diseases
• Infectious Diseases Society of America
• Merck Sharp & Dome Faculty club
Advisor
• “Nederlandse Meningitis Stichting”
Board member
• BMC Infectious Diseases
• “Purple Pages” Pediatric Infectious Diseases Journal
Chair
•
•
•
•
Board member
• European School of Urology (ESU)
• National working party on Urological Cancers
• Dutch Urological Oncological Study Group (DUOS)
Member
• Multimedia Officie, European Association of Urology
• Urology committee, Comprehensive Cancer Center
Amsterdam
• Werkgroep Oncologische Urologie, Nederlandse
Vereniging voor Urologie
• Werkgroep Prostaatcarcinoom, Zichtbare Zorg
ziekenhuizen
Member, treasurer
• Ver. MODHEM (Dutch Network For Molecular Diagnostics
For Hematological Malignancies)
Member
• Ned. Ver. Voor Gentherapie
Co-organizer
• First international workshop on preclinical RA, Reade,
Amsterdam 26.1.2011; second workshop was held prior to
ACR Annual Meeting, November 2011 Chicago
Member
• EULAR committee for the study of the earliest stages of
RA
Chair
• European DIPG network
Member
• DCOG protocol committee Medulloblastoom
Van Dulmen-den Broeder E
Van Furth AM
Van Moorselaar RJA
Van Oostveen JW
Van Schaardenburg D
Van Vuurden DG
Video Committee European Association of Urology
Medical Innovation Board TNO
Scientific committee Dutch Urological Association
Dutch Urological Oncological Guidelines Committee on
bladder instillations, Dutch Urological Association
• Subgroup Minimal Invasive Oncology SWEN (working Party
Endourology), Dutch Urological Association
73
Associate
Function
Organisation
• DCOG protocol committee Hooggradig glioom
• DCOG committee onderzoek nieuwe geneesmiddelen
Van Waesberghe JH
Member
• NVvR (Dutch Society of Radiology)
• Abdominal Section, NVvR (Dutch Society of Radiology)
• ESGAR (European Society for Gastrointestinal and
Abdominal Radiology)
Chair
• Adviescommissie Centrum Infectieziektenbestrijding van
het RIVM
• Bestuur Nederlands Tijdschrift voor Geneeskunde
• Registratiecommissie ISIS, Centrum
Infectieziektenbestrijding van het RIVM.
Member
• Programmacommissie Infectieziektenbestrijding van
ZonMw
• Programmacommissie Antimicrobiële Resistentie van
ZonMw
• NWO, TOP Commissie
• Antonie van Leeuwenhoek Stichting
• Commissie Wetenschap Sint Lucas Andreas Ziekenhuis
• Jury of the Innovation Academy Award of the
International Conference on Prevention and Infection
Control (ICPIC)
• Alliance Francophone Contre le dévelopement des
Bactéries Multi-Résistantes aux Antibiotiques (AC de
BMR)
Board member
• Nederlandse Vereniging voor Medische Microbiologie
Evaluator
• European Comission, FP7-HEALTH-2011-single-stage
Veening MA
Member
•
•
•
•
•
Veerman AJP
Visiting professor
• Universitas Gadjah Mada, Yogyakarta, Indonesia
Member
• External Advisory Board VIVA Foundation, Singapore
• Commissie Ontwikkelings samenwerking KWF
• Adviesraad International Course Health Development (VU
en Kon. Instituut voor de Tropen)
• Advies commissie Centrum Internationale Samenwerking
(CIS) VU
Chair
• Stichting Ontwikkelings Samenwerking Vumc
• DCOG protocol Committee ALL-9
Board member
• Estella Fonds
Verbeke JIML
Member
• NVvR (Dutch Society of Radiology) met lidmaatschap
sectie kinderradiologie
• KBVR (Koninklijke Belgische Vereniging Radiologie)
• ESPR (European Society of Paediatric Radiology)
Verheul H
Member
• Cie-BOM
Co-Chair
• TAT congres
Visser O
Member
• Lid Nederlandse Vereniging voor Hematologie
• Lid European Haematology Associateion
• Lid American Society of Hematology
Voskuyl AE
President
• Dutch working party of systemic sclerosis
• Stichting Registratie Systeemziekten Nederland
• Trial Steering Committee: ZIPP (zoledronate in prevetion
of Paget) trial. P.I. S Ralston, Edinburgh, UK
Chairman
• CBO Dutch consensus on the diagnosis of small vessel
vasculitis
74
Adviescommissie Neonatale Screening (ANS SIKK) NVK
Landelijke Werkgroep Hemoglobinopathie Behandelaren
Landelijke pediatrische werkgroep trombose en stroke
DCOG protocol Committee ALL-11
DCOG committee LATER
Associate
Function
Organisation
Co-Chairman
• OMERACT Executive Committee. (see www.omeract.org)
• EULAR Committee on conduct and reporting of long-term
extension studies in rheumatology
Member
• EULAR Committee on disease activity measurement in
rheumatoid arthritis.
• EULAR Committee on monitoring of glucocorticoid
therapy in rheumatoid arthritis
• OMERACT Task Force on imaging in rheumatoid arthritis
• ASAS, international consensus group on guidelines for
outcome measures in ankylosing spondylitis
• COMET Steering Group. International initiative to create
measurement core sets for trials across diseases
President-elect
• Society of Radiopharmceutical Sciences
Board member
• Nederlandse Vereniging Nucleaire Geneeskunde
• Nederlandse Klinische Radiochemici Vereniging
Member
• EANM radiopharmaceutical legislation working group
• EANM comittee PET in Drug Development
• Advisory board, EANM Radiopharmacy course
Member
• Commissie patienteninformatie (Nederlandse Vereniging
voor Dermatologie en Venerologie
Clinical Assessor Dermatology
• Dutch medicines evaluation board CBG-MEB and EMEA
Wondergem MJ
Member
•
•
•
•
EHA
ASH
NVVH
NIV
Wurdinger T
Member
•
•
•
•
•
•
LSH (Ambassador (http://www.lifescienceshealth.com)
Scientific consultant Thomson Reuters
Advisory board Genomic Enterprise
Advisory board of Stichting Liefde in de stad
Cultural science group Great Apes
RNAi Global Initiative
Board member
• Stichting Tractor
Research Fellow
• Massachusetts General Hospital/Harvard Medical School
Member
•
•
•
•
•
•
Chairman
• HOVON Imaging Werkgroep
Member
• Dutch Local Liaison Physician of the Severe Neutropenia
International Registry
• HOVON Multiple Myeloma Working group
• Organizing committee of the Dutch Hematology Conference
• Werkgroep Niet-Oncologische Hematologie van de
Nederlandse Vereniging voor
• Hematologie, voorzitter subcommissie
myeloproliferatieve aandoeningen
• Commissie Klinische Studies, Koningin Wilhelmina Fonds
• European Multiple Network biobanking committee
• werkgroep Zorgpaden, zwaartepunt Kanker
• selectiecommissie Klinische Fellowships KWF
Chairman
• Hematology Working Group, Cancer Center Amsterdam
• Thema Zorgprocessen, programma GPS
Executive Board member
• European Myeloma Net Trialist Group
Windhorst AD
Wintzen M
Zijlstra JM
Zweegman S
Nederlandsche Internisten Vereeniging (NIV)
Nederlandse Vereniging voor Hematologie (NVvH)
European Haematology Association (EHA)
Steering Committee German Hodgkin Study Group
HOVON
GHSG
75
Lectures
Associate
Title
Organisation
Ameziane N
Novel comprehensive mutation screening
approach for FA by multiplexed targeted
next-generation sequencing
23rd Annual Fanconi Anemia Research Fund
Scientific Symposium, October 20-23,
Barcelona, Spain
Appelmelk BJ
I want to get in: Pathogenic mycobacteria
express a multitude of DC-SIGN ligands
Dept. Microbiology Nottingham, UK, 15 maart
2011, Nottingham, UK
Ligands galore! Pathogenic mycobacteria
express many DC-SIGN
Seminar, Department for Molecular
Biomedical Research, Universiteit Gent,
Belgie, 5 mei 2011, Gent, Belgie
Cap stories and PGL rBCG:lipids
Meeting NEWTBVAC WP3 Institut Pasteur
Paris, 13 september, Parijs
The Mystery of the Multiple Mannose
Moieties of pathogenic Mycobacteria
Glycobiology Japan - Netherlands Joint
Seminar 2011, Nagoya, Japan
Poster presentation: “TRAIL-induced kinases
activation in Non small cell lung cancer
cells”
AACR annual meeting 2011, Orlando, The
United States
Poster presentation: “ Molecular mechanism
of TRAIL-induced migration and invasion in
resistant NSCLC cells”
TI Pharma Spring meeting, Utrecht, the
Netherlands. (award: best poster)
Poster presentation: “TRAIL-induced kinases
activation in Non small cell lung cancer
cells”
WCLC 2011, Amsterdam, the Netherlands
Low connexin-26 predicts the development
of metastasis after radical prostatectomy
102nd AACR Conference, 2-6 april 2011,
Orlando, USA
MicroRNAs to identify high-risk prostate
cancer
EORTC-EGAM, 1-4 march 2011, Brussels,
Belgium
Bitter W
ESX-5, one of the type VII secretion systems
Eigth International Conference on the
Pathogenesis of Mycobacterial Infections, 30
June-3 July, Saltsjöbaden, Sweden
Boellaard R
PET image reconstruction methods
Brain & BrainPET meeting, 2011, Barcelona,
Spain
Qantitative FDG PET/CT imaging in oncology
Annual meeting of the Austrian Society of
Clinical Physics, 2011, Bregenz, Austria
Standardisation of FDG PET/CT imaging for
quantitative tracer uptake and automated
metabolic volume assessments
Belgium Hospital Physicists Association
meeting, 2011, Charleroi, Belgium
PET/CT in the practice of oncology
RMS 14th Annual PET/CT meeting, 14-15
March 2011, London, UK
How to evaluate a novel tracer
Annual Turku PET Symposium, 2011, Turku,
Finland.
FDG PET/CT standardisation efforts in
Europe
NCRI meeting, 2011, London, UK
The first results of / experiences with the
FDG PET/CT
EORTC GROUPS ANNUAL MEETING (EGAM),
2011, Brussels, Belgium
Why high resolution in PET –
introduction/review
EANM conference, 2011, Birmingham, UK
Mixed treatment comparison of biologics in
RA.
Roche Morocco Scientific Meetings in
Casablanca and Rabat
New RA remission criteria.
UCB Scandinavian Scientific Meeting,
Stockholm, Sweden
OMERACT, how does it work?
2nd HOME meeting on outcome measurement
in atopic dermatitis, Amsterdam
New remission criteria /
90 minute workshop on scientific graphs
EULAR, annual meeting London, UK
Experimental study designs /
Design of RCT’s in RA.
Annual meeting of the Turkish Society for
Rheumatology Antalya, Turkey
Azijli K
Bijnsdorp IV
Boers M
76
A conceptual framework for outcome
measurement
Bristol, UK, COMET 2 meeting
A conceptual framework for outcome
measurement
Leicester, UK CTU rounds
120 minute workshop on scientfic graphs
ACR, annual meeting Chicago
The history of treatment of RA
December Scientific Meeting Piestany,
Slovakia
Bongers E
Chest wall toxicity following risk-adapted
stereotactic radiotherapy for early stage
lung cancer
WCLC Amsterdam July 2011
Braakhuis B
HPV in head and neck squamous cell
carcinomas: an update
Polish Society of Otorhinolaryngology.
Warsaw, September 23, 20
Braamse A
Which factors predict health-related quality
of life in patients treated with HSCT for
hematological malignancies?
13th World Congress of the International
Psycho-Oncology Society (IPOS), 17 - 19
October, 2011, Antalya, Turkey
Brakenhoff RH
Hoofdzaken
PAOK NVMKA, January 21st, Nunspeet
Update in oral cancer: research, diagnosis
and treatment
June 30th, July 1st, Parma- Italy
The molecular biology of head and neck
cancer
ESTRO Anniversary Congress
ExCel, May 6-12th, London
cancer
Dusseldorfer Fanconi anemia symposium, May
26th Dusseldorf
cancer
Annual Meeting CTMM, September 29th,
Utrecht
cancer
4th European Head and Neck Cancer Course,
October 5-7th, Amsterdam
cancer
NAMOBICA, New Approaches to Molecular
Biology of Cancer, October 18th, Oviedo Spain
Broers CJM and van Furth
AM
Influenza A virus bij kinderen met syndroom
van Down
Down symposium, dec 2011, VU, Amsterdam
Cloos J
Leukemic stem cell identification in AML
2nd Open Scientific AML-BFM Research
Symposium, 10-11 September 2011,
Hannover, Germany
de Bree R
Management of Oral Cancer
European Meeting on Oral Disease: diagnosis
and management. 11 mei 2011, Amsterdam
de Gruijl T
Lymphoid and myeloid biomarkers for
clinical outcome of ipilimumab and Prostate
GVAX treatment
Annual Meeting of the Society for the
Immunotherapy of Cancer (SITC), 4-6
November 2011, Washington DC
De Winter JP
Replication coupled genome maintenance
Research visit UMCG (host Frank Kruyt), 1103-2011, Groningen
Idenfication of novel players in the Fanconi
anemia/BRCA pathway
Conference “Responses to DNA damage from
molecular mechanism to Human disease”, 0404-2011, Egmond aan Zee
Warsaw Breakage Syndrome, a novel
cohesinopathy associated with mutations in
the XPD helicase family member DDX11
Third informal meeting, ”Cohesin biology and
the cohesinopathies”, 22-05-2011,
Il Ciocco, Italy.
Unraveling the Fanconi Anemia/BRCA
pathway
First Düsseldorfer Fanconi-Anamie
symposium, 26-05-2011, Dusseldorf, Germany
Sister chromatid cohesion and human
disease
8th European Cytogenetics Conference, 04-072011, Porto, Portugal
Sister chromatid cohesion and genome
maintenance
41st Annual meeting European Environmental
Mutagen Society, 06-07-2011, Barcelona,
Spain
77
Dorsman JC
A next-generation sequencing prioritization
tool tailored for uncovering novel FA genes
23rd Annual Fanconi Anemia Research Fund
Scientific Symposium, October 20-23,
Barcelona, Spain
Gibbs S
Epidermal An in vitro Equivalent Assay to
determine sensitizer potency.
Workshop Nature BV Paris, 8 december 2011,
Paris, France
The Sens-it-iv tool box of in vitro assays
Workshop Sao Paulo University, Brazil, 18
October, 2011, Sao Paula, Brazil
The Sens-it-iv tool box of in vitro assays
Lecture Natura BV Brazil, 21 October 2011,
Sao Paulo, Brazil
Dendritic Cell Migration assay to detect
sensitizers
Sens-it-iv end symposium for Stakeholders,
23-24 November 2011, Brussels, Belgium
Epidermal Equivalent potency assay
Full Thickness Skin Equivalent with
Integrated Langerhans Cells
Epidermal An in vitro Equivalent Assay to
determine sensitizer potency
Workshop: BASF, Germany, 10 February,
2011, Berlin, Germany
Tissue engineered skin for pressure ulcer
treatment and repair name
EPUAP congress, 1 September 2011, Oporto,
Portugal
Retrospective analysis of patients with
(arterio-)venous, post-traumatic or pressure
ulcers treated with autologous skin
substitute
ETRS congress, 5-7 September 2011,
Amsterdam
Simple wound exudate collection method
identifies bioactive cytokines and
chemokines in (arterio-) venous ulcers
ETRS congress, 5-7 September 2011,
Amsterdam
MUTZ-LC migration assay for assessing
sensitization
results from a ring study
ERGECD congress, 9-11 September 2011,
Gottenberg, NL
Langerhans Cells derived from a human cell
line in a full-thickness skin-equivalent
undergo allergen-induced
maturation and migration
Aegean Conferences 4th Tissue Engineering,
31 May – 5 June 2011, Crete, Greece
Development and validation of a human,
full-thickness tissue-engineered
hypertrophic scar model
Aegean Conferences 4th Tissue Engineering,
31 May – 5 June 2011, Crete, Greece
Gordijn MS
Sleep, fatigue and quality of life after
treatment for childhood acute
lymphoblastic leukemia
SIOP (International Society of Paediatric
Oncology) congress 2011, 26-30 October
2011, Auckland, New Zealand
Haasbeek CJA
SABR for Stage 1 NSCLC
Patient Selection, Fractionation Schemes (3
July 2011)
Late Outcomes of Stereotactic Ablative
Radiotherapy (SABR) for Centrally Located
Stage I Lung Cancer
(5 July 2011)
Improvements in survival of elderly patients
with stage I NSCLC in the Netherlands
between 2003-2009
Presidential Symposium (6 July 2011)
World conference on lung cancer (WCLC)
Amsterdam juli 2011
Hensen EF
78
Improvements in Survival of Elderly Patients
with Stage I NSCLC in the Netherlands
between 2003-2009
ASTRO, Miami, 5 October 2011
Cochlear implantation in very young
children
10th European Symposium on pediatric
cochlear implantation. Athene, Griekenland,
12-15 mei 2011
Paragangliomen en erfelijkheid
8e Patientendag Nederlandse vereniging voor
patiënten met paragangliomen (NVPG)
VU academisch medisch centrum,
Amsterdam, 29 oktober 2011
Hoekstra OS
Jansen G
Cochleaire implantatie na meningitis
Symposium gehoorverlies na meningitis:
diagnostiek, preventie en behandeling.
Observer variation: whose achilles’ heel is it
anyway?
Langendorff Radiotherapy meeting,
2011, Freiburg, Germany
Finetuning of FDG PET-CT in non small cell
lung cancer
International lung cancer meeting, 2011,
Turin, Italy.
PET-MRI: a new kid on the block
World Congress of Lung Cancer, 2011,
Amsterdam, NL
Peptide epoxyketone-based proteasome
inhibitors are substrates for P-
EORTC-Pharmacology and Molecular
g Mechanism meeting, February 2-5, 2011,
Gdansk-Sopot, Poland
Biochemistry and physiology of transport
and polyglutamylation of folates
Role of levoleucovorin vs folic acid in
potentiation of 5-FU October 25, 2011, New
York, USA
Molecular mechanisms of resistance to an
aminopeptidase inhibitor prodrug
November 20, 2011, The Technion, IsraelInstitute of Technology, Haifa, Israel
Janssen JJWM
A new flow cytometric approach to
discriminate malignant from normal stem
cells in CML.
ESH/iCML, 23-25/9/2011, Estoril
Jimenez CR
Label-free mass spectrometry-based
proteomics for biomarker discovery and
validation in tissues and biofluids
11 feb. 2011. SEPROT 2011, Segovia
CSF proteomics reveals pathogenesis and
novel candidate biomarkers for mild
cognitive impairment and Alzheimer’s
Disease
30 mei 2011. EndoNeuroPsycho meeting, ENP
2011. Lunteren
Developmental Models and Data Integration,
Dublin. "Label-free mass spectrometrybased proteomics for biomarker discovery in
murine and human cancer
20 juni 2011, Cancer Proteomics 2011:
Systems Biology
Progress in CSF biomarker discovery for mild
cognitive impairment and Alzheimer’s
Disease by label-free quantitative
proteomics
20 juli 2011. AAICAD 2011, Paris
proteomics for biomarker discovery and
validation in tissues and biofluids
25 sept. 2011. Multidisciplinary European
Cancer Congress, Stockholm
Protein biomarkers for cisplatin treatment
response prediction in non-small cell lung
cancer
29 sept. 2011. Annual CTMM meeting Utrecht
proteomics for biomarker discovery in
murine and human cancer
10 okt. 2011. Freiburg
Joenje H
DNA instabiliteit: de voors en tegens
Symposium in honor of the retirement of
prof.dr. Hans Joenje, 16 March 2011, VU
main building, Amsterdam
Kaspers GJL
Retinoblastoma
Second Workshop on Pediatric Oncology, 11
January 2011, Eldoret, Kenya
Wilms tumors
Acute Oncology
Use of treatment protocols
Febrile neutropenia
Pitfalls in pediatric oncology
79
Kirtschig G
Kluytmans JAJW
80
Bortezomib in pediatric relapsed ALL
Annual meeting I/BFM/SG Committee on
Refractory Disease, 12 February 2011,
Birmingham, UK
view from the I-BFM tials experience for
relapsed AML
Acute Myeloid Leukemia: pathways, targets
and drug development, A collaborative
workshop between ITCC, I-BFM, KCK, ENCCA,
15 April 2011, Paris, France
DCOG view on clinical application of AMLMRD in the future
AML-MRD meeting of the I-BFM-SG/AML
committee, 5 May 2011, Gdansk, Poland
Update on ICC APL Study 01
Annual meeting of the International BFM
Study Group, 6 May 2011, Gdansk, Poland
Update on Relapsed AML 2010/01
ITCC021: bortezomib ın relapsed ALL; IBFM-SG experıences
A common treatment backbone: European
Pediatric AML protocol
Pediatric AML: Relapse treatment and new
treatment options
3rd International Congress on Leukemia,
Lymphoma & Myeloma, 14 May 2011,
Istanbul, Turkye
International collaboration towards
improved treatment of pediatric AML
6th Prof. Rina Zaizov Memorial Symposium,
28 June 2011, Petah-Tikva, Israel
Pediatric AML: an introduction
Indonesian Workshop on pediatric leukemia,
30 September 2011, Yogyakarta, Indonesia
Pediatric AML protocol in Indonesia
Indonesian Workshop on pediatric leukemia,
1 October 2011, Yogyakarta, Indonesia
Pediatric APL
Annual SIOP meeting, 28 & 29 October 2011,
Auckland, New Zealand
Chairman sessions of the scientific
committee on Lymphoid Neoplasia:(Dys-)
Regulation of cell metabolism in lymphoid
neoplasia
Annual Meeting of the American Society of
Hematology, 10 & 11 December 2011, San
Diego, USA
Erkrankungen der Mund- und
Genitalschleimhautname
46. Tagung der Deutsche Dermatologische
Gesellschaf, 31st March, 2011, Dresden,
Germany
Systemische und lokale Behandlung in der
Schwangerschaft
46. Tagung der Deutsche Dermatologische
Gesellschaft, 31st March, 2011, Dresden,
Germany
Overview of Livestock Associated MRSA and
Some Speculations, About the Future
12th Annual NARSA Investigators Meeting, 7 8 maart 2011, Reston, Virginia,USA
Cost-Effectiveness for Use of Molecular
Detection in Disease Diagnostics
2nd ASMET – The ASM Emerging Technologies
Conference, 8 - 11 maart 2011, San Juan,
Puerto Rico
Decolonization strategies – Nosocomial
infections
31st International Symposium on Intensive
Care and Emergency Medicine, 22 - 25 maart
2011
Fungal infections – Standard presentation
(moderator)
Care and Emergency Medicine, 22-25 maart
2011, Brussel
The role of the community – Problematic
organisms
Care and Emergency Medicine, 22 – 25 maart
2011, Brussel
ESBL and other problematic Gram-negative
organisms – Problematic organisms
2011, Brussel
SDD in 2011 – Pro-con debate
2011, Brussel
Continuous vs intermittent – Antimicrobial
therapy
2011, Brussel
Health hazards of antibiotic resistance in
food and the environment
3rd Edition World HAI Forum Control of
Antimicrobial Resistance, 27 – 29 juni 2011,
Les Pensières
Increase of ESBL in animals and humans:
you are what you eat
International Conference on Prevention &
Infection Control, 29 juni – 2 juli 2011,
Geneve
Modifiable risk factors for surgical site
infection
Geneve
MTE: Peri-operative Staphylococcus aureus
screen and decolonization: who, what,
when, where and how?
Geneve
Interactive lecture Surgical site infections
ESCMID-SHEA Training Course in Hospital
Epidemiology, 3 – 6 september 2011, Brunnen
Antimicrobial Use
Epidemiology, 3 – 6 september 2011,
Brunnen
MRSA
Brunnen
Mission and strategy planning in infection
control
Brunnen
Moderator Surgical Site Infections
51st ICAAC, 17–20 september 2011, Chicago
ESBL: current epidemiological aspects and
pitfalls for detection
MRSA und ESBL Workshop, 27 september
2011, Wenen
MRSA: current epidemiological aspects and
pitfalls for detection
MRSA und ESBL Workshop, 27 september
2011, Wenen
Koken PW
Transition to 3D MR-only gynaecological
brachytherapy: first VUmc experiences
Varian Users Meeting, Berlijn (D), (19-22
oktober 2011)
Lagerwaard FJ
Stereotactic Ablative Radiotherapy (SABR)
for pathologically confirmed stage I NSCLC.
ASTRO Oct 2011, Miami.
Stereotactic Ablative Radiotherapy (SABR):
The new standard for high-risk Stage I
NSCLC patients?
ESTRO 2011, London
Initial experience with HybridArc™
radiosurgery planning for intracranial
targets.
ISRS 2011, Paris
Clinical outcomes of stereotactic ablative
radiotherapy for Stage I non-small cell lung
cancer
ISRS 2011, Paris
A Pooled Analysis of Arc-based ImageGuided Simultaneous In-Field Boost
Radiation Therapy For Oligometastatic Brain
Metastases
ISRS 2011, Paris
The radiosurgery programme at VUmc.
ISRS 2011, Paris. Varian symposium
Synchronous brain metastases from NSCLC:
Time for a reappraisal of systemic
treatment?
WCLC 2011, Amsterdam
Stereotactic ablative radiotherapy (SABR) in
potentially operable Stage I non-small cell
lung cancer patients
WCLC 2011, Amsterdam
HybridArc™ for intracranial tumors: an
initial review.
BrainLAB users meeting, Munchen
Lung stereotactic ablative radiotherapy
(SABR): Evolution at VUmc 1993-2011.
Varian users meeting, Berlin
Perspectives in Radiotherapy for high grade
gliomas.
NVRO, Utrecht, 2011
81
Langius JAE
Leemans CR
82
Stereotactic body radiotherapy as an
alternative to surgery in patients with stage
I NSCLC.
ASCO 2011, Chicago
Is irradiation of potential cancer stem cell
niches in the subventricular zones
indicated?
EORTC-EANO Mar 2011, Bucharest
The predictive value of the extent of
surgical resection in newly diagnosed
glioblastoma multiforme (GBM)
Interval progression between surgery and
adjuvant treatment can mimic (pseudo)progression of glioblastoma multiforme
(GBM).
Whole Brain RadioTherapy with or without
synchronous integrated boost in patients
with 2 to 5 brain metastases: a Phase III
Study of the EORTC ROG and BTG. MRI side
study. EORTC trial 22111-26111.
EORTC Imaging Group, Sept 2011, Freiburg
Stereotactic radiosurgery for pulmonary
metastases
European Multidisciplinary Conference in
Thoracic Oncology (EMCTO), Feb 2011,
Lugano
Resting energy expenditure in head and
neck cancer patients before and during
radiotherapy
2nd International Conference on Cancer
Nutrition Therapy, March 29-30, 2011,
Edinburgh, Scotland
The association between weight loss and
survival in head and neck cancer patients
receiving radiotherapy
33rd ESPEN congress of clinical nutrition and
metabolism, September 3-6, 2011,
Gothenburg, Sweden
Experiences with criteria for determination
of precachexia and cachexia in cancer
patients
33rd ESPEN congress of clinical nutrition and
metabolism, September 3-6, 2011,
Gothenburg, Sweden
De voedingstoestand van patiënten met
hoofdhalskanker
Symposium kopzorgen en halszaken, March
25, 2011, Amsterdam
Multidisciplinary discussion of a locally
advanced and 1st line recurrent/metastatic
SCCHN patient case
Satellite Symposium Integrated treatment
decisions in squamous cell carcinoma of the
head and neck at the 3rd ICHNO, February
25, 2011, Barcelona, Spain
Surgical Salvage for Head and Neck Tumors
after Chemoradiation Failure
3rd International conference on Innovative
Approaches in Head and Neck Oncology
(ICHNO). February 24-26, 2011, Barcelona,
Spain
Salvage Surgery for Head and Neck Tumors
after Primary Organ-preservation Treatment
6th Leipzig International Course in Head and
Neck Surgery and Oncology Larynx and
Hypopharynx, March 9-12, 2011, Leipzig,
Germany
Management of Oral Cancer
Annual Meeting Danish Society for Head and
Neck Oncology, March 25, 2011, Copenhagen,
Denmark
Management of Recurrent Salivary
Pleomorphic Adenoma
Turkish Ear Nose Head and Neck Surgery
Foundation – 9th National Academy Meeting,
April14-17, 2011, Dalaman, Turkey
HPV in Head and Neck Cancer
Foundation - 9th National Academy Meeting,
April14-17, 2011,
Dalaman, Turkey
Surgical Salvage for Head and Neck Tumors
Foundation – 9th National Academy Meeting,
April14-17, 2011,
Dalaman, Turkey
Treatment of Salivary Gland Tumors.
European Meeting on Oral Diseases
Diagnosis and Management, May 11-13, 2011,
Amsterdam, The Netherlands
Current Management of of Advanced
Laryngeal Cancer
1st Congress of the Confederation of the
European ORL-HNS/26th Congreso Nacional de
la SEORL, July 2-6, 2011, Barcelona, Spain
Does Organ Preservation Exist for
Oropharyngeal Carcinoma?
Human Papillomavirus and Head and Neck
Cancer
Surgical Salvage for Head and Neck Cancers
Annual Meeting Collegium Oto-RhinoLaryngologicum Amicitiae Sacrum, September
5-7, 2011, Bruges, Belgium
Management of oral cancer
European Head and Neck Course, October 57, 2011,
Parapharyngeal tumours
European Head and Neck Course, October 57, 2011, Amsterdam, The Netherlands
The Role of the Surgeon in the Era of
Changing Patterns of Epidemiology and
Treatment
118ème Congrès de la Société Française
d’Oto-Rhino-Laryngologie et de Chirurgie de
la Face et du Cou, October 15-17, 2011,
Paris, France
Functional Unresectability’ in Advanced
Head and Neck Cancer
3rd trends in Head and Neck Oncology,
November 3-5, 2011, Rome, Italy
Eular: Osteoporosis prevention after initial
fracture
London 27th of May, 2011
Dutch CBO Guideline
Belgian Congress of Rheumatology:.
(Antwerpen, 28th of September 2011)
Osteoporosis
Eular postgraduate Course, 1 october, Dublin
Osteoporosis in Rheumatic Diseases
OsteoRheumatology “International Meeting
on Bone Involvement in Arthitis””:. 14th of
October 2011 San Margherita, Italy
Lecture on the Dutch Osteoporosis
Guideline
Symposium: the clinical approach to
postmenopausal women with a history of
fracture.. Brussels, 16th of December 2011
Lecture on: Treatment of Glucocorticoid
Induced Osteoporosis
Symposium “The Severely Osteoporotic
Patient Anabolic Treatment and Diagnosis” ,
sponsored by Eli Lilly., Brussels 8th of October
2011
Clinical Profile of Bone Forming Agents in
the Treatment of Glucocorticoid-induced
Osteoporosis (GIOP)
Symposium, , sponsored by Eli Lilly, satellite
of EULAR. Management of GIOP. 25th of May
2011
Meyer OWM
Single- and Hypofractionated Radiosurgery
for Acoustic Neurinomas
3rd European Novalis Radiosurgery
Symposium. November 4th 2011, Freiburg,
BRD
Mostert S
Epidemiology and treatment outcome of
childhood cancer in Western Kenya
Course of Pediatric Oncology, 11 January
2011, Eldoret, Kenya
Compliance with childhood leukemia
treatment in Indonesia
Meeting: Course of Pedatric Oncology, 12
Workshop on Compliance
Course of Pediatric Oncology, 12 January
2011, Eldoret, Kenya
Abandonment of childhood cancer
treatment in Indonesia and Kenya
SIOP congress, 27 October 2011, Auckland,
New Zealand
Lems W
Ossenkoppele GJ
AML in the elderly
Cancer in the elderly, Rome februari 2011
AML in the elderly
EHA June 2011 Londen
Sensitizing AML stem cells
Finnish Society of Hematology, februari 2011
Intensive treatment in elderly AML or not
ELN
Frontiers meeting Berlin oct 24,25
Minimal residual disease in AML
ESH meeting Estoril Portugal oct 2011
Treatment of AML
Swedish Society of Hematology nov 2011
Stockholm
83
AML stemcells
Scientific meeting Karolinska Institute
Stockholm
Practice, Attitude and Knowledge regarding
fertility preservation techniques in the
Netherlands (the PAK-study): reports of the
pilot study
ESLCCC, 28-29 September 2011, Amsterdam
Specialist’s view
Fertiliteitspreservatie.nl, 15 december 2011,
Oegstgeest
Introduction to the Lloyd Kelland Lecture by
Stephen Neidle
32nd EORTC PAMM meeting, February 3 2011,
Sopot-Gdansk – Poland
New avenues for antimetabolites: will drug
delivery improve their efficacy?
February 18, 2011, Nippon-Kayaku, Tokyo,
Japan
Background of antimetabolite action and
development in cancer
14th International Symposium on Purine and
Pyrimidine Metabolism in Man, February 20,
2011, Tokyo, Japan
Drug delivery as a successful approach to
improve the efficacy of antimetabolites
2011, Tokyo, Japan
A reflection on well-known Purine and
Pyrimidine scientists
2011, Tokyo, Japan
Pharmacogenetics in gastrointestinal tumors
EORTC Joint Translational Research Division
meeting, EGAM, March 2, 2011, Brussels,
Belgium
Protein Kinase C-beta (PKC-beta) as a target
and modulator for novel cancer therapies
Kobe University Exchange symposium, March
4, 2011, Brussels, Belgium
Resistance to antimetabolites: Mechanisms
and modulation
Aeterna Zentaris, June 14, 2011, Frankfurt,
Germany
Targeted modulation of signaling pathways
as basis for novel combinations
Aeterna Zentaris, June 14, 2011, Frankfurt,
Germany
Prodrugs in anticancer treatment: an
opportunity for new modulation strategies
EACR – Anticancer agents research congress,
October 13, 2011, Antalya, Turkey
Fusilev: Interaction with 5FU, antifolates
and other drugs
Spectrum Pharmaceuticals Educational
meeting, October 24, 2011, New York, NY,
USA
Phernambucq E
‘Quantifying pulmonary function changes
after stereotactic ablative radiotherapy
(SABR) for stage I non-small-cell lung cancer
WCLC Amsterdam July 2011
Piersma SR
Collagen prolyl 3-hydroxylation in
Osteogenesis Imperfecta: a rare
modification in a rare disease
28 okt. 2011. Fall meeting Netherlands
Proteomics Platform, Leiden
Rustemeyer T
Contact allergy: immunological reactions in
tolerance
Swedish Immunology Meeting, 21 January
2011, Gothenburg, Sweden
Immunological reactins to terpens
Swedish Immunology Meeting, 21 January
2011, Gothenburg, Sweden
Contact dermatitis to co-polymers
EECDRG, 2-4 April 2011, London, Great
Britain
Trends and new allergens in Europe
Britain
European multi centre study on palladium
Britain
Contact allergy: immunological mechanisms
World Congres of Dermatology, 24-29 May
2011, Seoul, South Korea
Contact allergy to PPD
PPD consortium, August 12, 2011, Trier,
Germany
Contact dermatitis to metal implants
EECDRG, 16-18 September 2011, Leuven,
Belgium
Contact allergy in Europe
Belgium
Overbeek A
Peters GJ
84
European multi centre study on palladium
and titanium
Belgium
Photodermatitis: mechanisms and clinical
pictures
EADV, 19-24 September 2011, Lissabon,
Portugal
Contact allergy is more than eczema
Portugal
In vitro detection of contact allergens: a
novel approach
Gothenburg University Celebrations, 9
December 2011, Gothenburg, Sweden
Contact allergy: a risk factor of
autoimmune diseases?
Gothenburg University Celebrations, 9
December 2011, Gothenburg, Sweden
Sanders M and van Furth AM
Genetic variation of innate immune
response genes in invasive pneumococcal
and meningococcal disease
Toll 2011, May 2011, Riva del Garda, Italy
Savelkoul JAJW
New developments in molecular detection
of gutflora and the presence of parasites
Congress in honour of 50 years the
Netherlands Society for Parasitology,
24/25/26 January, Utrecht
Analysis of Multi-Bacterial Specimen by
ISPRO
ASM Conference on Regulating with RNA in
Bacteria, 4/5/6 March, San Juan, Puerto Rico
Schuurhuis GJ
Flow cytometric detection of MRD-the
HOVON/SAKK experience
23rd European Leukemianet MRD Workpackage
meeting, (invited), 1-2-2011, Mannheim
Schuurhuis GJ
Novel Markers for LSC in
immunophenotypically and functionally
defined Progenitor Subsets (invited)
Year 2011 working conference on cancer
stem cells (invited), Sept 3rd 2011, Vienna
Senan S
How image-guided radiotherapy (IGRT) is
changing oncology practice: Lung tumors
and oligometastatic disease
University of Bern/Inselspital, Bern, 25th
February 2011
Lugano Consensus on early and locally
advanced disease
2nd European Multidisciplinary Conference in
Thoracic Oncology. Lugano, Switzerland,
February 24-26, 2011
Treatment of early-stage lung tumors &
oligometastatic disease: Impact of RapidArc
Azienda Ospedaliero-Universitaria di Parma,
Parma, Italia. April 6, 2011
Stereotactic radiotherapy for lung cancer:
strategies to influence referring physicians
BVRO-ABRO meeting, Liége May 27-28 2011
Controversies in stereotactic radiotherapy
for lung tumors
BVRO-ABRO meeting, Liége May 27-28th 2011
Treatment of lung cancer in stages I and II
Role of Radiotherapy. New Borders in Lung
Cancer Course, Clínica Alemana, SantiagoChile, 18-19th August 2011
Treatment of lung cancer in stages III and IV
Role of Radiotherapy. New Borders in Lung
Cancer Course, Clínica Alemana, SantiagoChile, 18-19th August 2011
PRO-CON debate on Preoperative chemoradiation for stage III lung cancer. New
Borders in Lung Cancer Course
Clínica Alemana, Santiago-Chile, 18-19th
August 2011
Stereotactic body radiotherapy for earlystage NSCLC
New Borders in Lung Cancer Course, Clínica
Alemana, Santiago-Chile, 18-19th August 2011
Translating Research in Imaging into Clinical
Practice for Stereotactic Ablative
Radiotherapy
CARO Annual Scientific Meeting, Winnipeg,
Canada, September 14-17, 2011
Lung Stereotactic radiotherapy. Utilizing
RapidArc on the TrueBeam System
Varian symposium at CARO Annual Scientific
Meeting, Winnipeg, Canada, September 1417, 2011
Advances in Lung Cancer Management
2011 Advances in Technology Clinical Forum,
Miami, Florida, 1 October 2011
Curative XRT for early stage lung cancer
11th Meeting of the International Society of
Geriatric Oncology (SIOG) on 4-5 November
2011 in Paris, France
Modern radiotherapy techniques and
progress in non-small cell lung cancer
2011 NCRI Cancer Conference, Liverpool, UK,
6-9 November 2011
85
Advances in chemoradiation for non-small
cell lung cancer
Meeting on ‘Advances in the Diagnosis and
Treatment of Lung Cancer: A Journey
Towards Personalisation of Therapy’. Royal
Marsden Hospital, London 24 November 2011
SABR of surgery for operable stage I NSCLC.
The ROSEL–trial. RTOG
San Diego, USA, 14-1-2011
Radiotherapy in ES-SCLC. RTOG
San Diego, USA, 15-1-2011.
SBRT for lung tumors: Lessons learned and
future directions
Cleveland Clinic 4th International symposium
on stereotactic body radiation therapy and
stereotactic radiosurgery. Orlando, USA, 272-2011
Whole brain radiotherapy with simultaneous
integrated boost for multiple brain
metastases
American Radium Society, Palm Beach, USA,
1-5-2011
Role of SBRT in non-small cell lung cancer
ESTRO, London, UK, 8-5-2011
Treatment of multiple brain metastases
using RapidArc
Int. Soc. Radiosurgery, Paris, France, 9-52011
Eight years of experience in SBRT at VU
University medical center
ESTRO Var Symposium, London, UK, 10-52011
High-tech radiation therapy: Where are the
limits?
Joint ESTRO-ASTRO Symposium, London, UK,
10-5-2011
Role of Radiotherapy in ES-SCLC
World Lung Cancer Conference, Amsterdam,
The Netherlands, 7-7-2011
Innovations in radiation oncology
Conference on New Technologies in
Radiotherapy. Philadelphia, USA, 21-7-2011.
ABR for NSCLC
Oncoville, Curitiba, Brazil, 31-8-2011
Hippocampus sparing WBRT
Oncoville Meeting, Curitiba, Brazil, 1-9-2011
IMRT and concommittant boost for brain
metastases
Oncoville meeting, Curitiba, 1-9-2011
Breakthroughs in the treatment of tumors of
the central nervous system
Oncoville meeting, Curitiba, 2-9-2011
SBRT in Stage I NSCLC
Brasilia, 19-10-2011
New Techniques in Radiotherapy: IGRT en
stereotactic radiotherapy
Symposia Annual Nucleo de Oncologia
Toracia, Rio de Janeiro, Brazil, 25-10, 2011.
SBRT for oligometastases. III Radiation
Therapy Symposium: IMRT, IGRT and
RapidArc
Hosp Israelita Albert Einstein, Sao Paulo,
Brazil, 9-12-2011
RapidArc for combined stereotactic
treatment and whole brain radiotherapy for
patients with multiple metastases
III Radiation Therapy Symposium: IMRT, IGRT
and RapidArc, Hosp Israelita Albert Einstein,
Sao Paulo, Brazil, 10-12-2011
The Role of Oxygen in Radiotherapy
Particle Training Network for European
Radiotherapy (PARTNER meeting), Wiener
Neustadt, Austria, February 20-24, 2011
Role of the Radiobiologist in Clinical daily
work
Particle Training Network for European
Radiotherapy (PARTNER meeting), Wiener
Neustadt, Austria, February 20-24, 2011
Brain Re-irradiation in Conventional and Ion
Beam Therapy
“Innovative Approaches in Cancer Diagnostics
and Treatment”, Scientific meeting of the
RegIonal Ion Therapy Austrian – Hungarian
Cooperation, Wiener Neustadt September 1516, 2011
Stoepker C
Genetic instability in sporadic head and
neck squamous cell carcinoma cell lines
DNA repair group, 09-09-2011, Leiden
Taphoorn MJB
Quality of life in brain tumour patients
Verona Neurosurgical Symposia, January 28,
2011, Verona, Italy
End of life care in glioma patients: what are
the issues?
EORTC-EANO annual meeting, March 26,
2011, Bucharest, Romania
Slotman BJ
Sminia P
86
Central nervous system toxicity of cancer
therapy
American Academy of Neurology (AAN)
Annual Meeting, April 10, 2011, Honolulu,
USA
Does it make sense to assess health-related
quality of life in brain cancer?
European Organization for Research and
Treatment of Cancer (EORTC) conference on
Quality of Life, September 8, 2011, Brussels,
Belgium
Health-related Quality of Life in brain
tumour patients
National Cancer Research Institute (NCRI)
Annual Conference, November 7, 2011,
Liverpool, United Kingdom
van Beusechem VW
Identification of miRNAs that modulate
adenovirus replication in cancer cells
6th International Conference on Oncolytic
Viruses as Cancer Therapeutics, March 16-19,
2011, Las Vegas, NV, USA
Van Bodegraven A
On navel gazing and storming heaven:
building clinical IBD networks
Oral presentation at SOIBD. Nov 2011
Stockholm, Sweden
Real-life experience with Adalimumab in
Crohn’s patients in The Netherlands
UEGW, Stockholm, Sweden. October 2011
IS-PRO: fully automated analysis of the
human intestinal microbiota
UEGW, Stockholm, Sweden. October 2011
Wenn to consult a dietician
Postgraduate Course Nurses Network IBD Care
(NNIC), Utrecht, The Netherlands, Sept 2011.
Guidelines and financing “Expensive Drugs”
Invitational Conference Diagnosis and
treatment guidelines; recent developments
and future prospects. The Hague, Jun 2011
Different Risk Factors for Colitis Associated
Colorectal Cancer in Ulcerative Colitis and
Crohn's Disease
Randomized Placebo-controlled Trial of
Risedronate in Patients with Crohn’s Disease
and Osteopenia: the Crohn and Bone study
ECCO Congress, Dublin, Ireland, February
2011
Tolerability and safety of conventional
thiopurines concomitantly with allopurinol
in IBD-patients with a skewed thiopurine
metabolism
ECCO Congress, Dublin, Ireland, February
2011
Prescribing thiopurines for IBD treatment in
the era of biologics is like flogging a dead
horse
Clinicopharmacological Meeting Linköping
University, March 2011, Linköping, Sweden
Risk factors for advanced neoplasia of the
rectal stump in IBD patients
Characteristics and feasibility of the
citrulline generation test to assess intestinal
mass in ICU patients
ASPEN, Vancouver, Canada, January 2011
6-Thioguanine, an alternative therapy for
refractory coeliac disease type I
UEGW, Barcelona, Spain. October 2010
Evaluating small bowel function in patients
with Multi Organ Dysfunction Syndrome
using a Citrulline Generation Test
ESICM, Barcelona, Spain, October 2010 and
orally at NESPEN/Nederlandse Vereniging voor
Gastro-enterologie en Hepatologie, Veldhoven,
March 20
Effectiveness and tolerability of
maintenance methotrexate therapy in
Crohn's disease patients; analysis of a
referral hospital-based 10-years intercept
cohort
Nederlandse Vereniging voor Gastroenterologie en Hepatologie, Veldhoven, March
2011 and UEGW, Stockholm, Sweden. October
2011
3 lectures on Uveitis in Spondylarthopathy
ASAS international Educational Courses, 20
January 2011 Brussels, 16 March, Brussels, 8
June, Munich
Lecture in genetics in AS
IGAS meeting, Shanghai, China, 11-14 March
Spondyloarthritis; lectures on genetics in
Spondylarthropathy and Extra-articula
manifestations in SpA
Charite Hospital, Berlin, 1 April, chair and
speaker workshop Diagnosis and Treatment
of (axial)
87
Lecture on Extra-articular manifestations in
Spondylarthropathy
EULAR, Londen, 26 May
Systems biology of cerebral granuloma
formation caused by mycobacterium
tuberculosis
ESPID, June 2011, The Hague, The
Netherlands
Systems biology of cerebral granuloma
formation caused by mycobacterium
tuberculosis
TB Keystone Symposium, Feb 2011,
Vancouver, Canada
PET imaging in rheumatology
The national meeting of rheumatology
(Najaarsdagen Reumatologie), september
2011
The status of MRI imaging in rheumatology
Sectra, 9 juni 2011
Van der Meij BS
Nutritional support in Graft-vs-Host disease
of the digestive tract
Annual meeting of Croatian Society of
Parenteral and Enteral Nutrition, May 21
2011, Opatija, Croatia
Van der Sar AM
The zebrafish embryo early granuloma
infection model: A promising tool for
antitubercular compound screens in vivo
Zebrafish Disease Models 4, Blood, Immunity,
Cancer and Endothelial workshop, July 9-11,
2011, Edinburgh, UK
The zebrafish embryo early granuloma
infection model: A promising tool for
antitubercular compound screens in vivo
Minisymposium: Non mammalian model
organisms, September 5-6, 2011, Tampere,
Finland
Leukoplakia
European Meeting on Oral Diseases. Diagnosis
and Management, 11-13 May 2011,
"Oral lichen planus with emphasis on
diagnosis and management" and "Oral
manifestations of systemic diseases"
Annual Meeting Swedish Society of
Pathology and Swedish Society of Clinical
Cytology, 18-20 May 2011, Umeå, Sweden
Advances in the diagnosis and treatment of
oral potentially malignant disorders
International Meeting of the Italian
Society of Oral and Maxillofacial Surgery
"Update in oral cancer: research,
diagnosis and treatment", 30 June-1 July
2011, Parma, Italy
Clinicopathologic Case presentation
40th Annual Meeting of the SFOPOM
(Scandinavian Fellowship for Oral
Pathology and Oral Medicine), 24-26
August 2011, Turku, Finland
Diseases of the mouth; diagnosis and
management
XIV Congreso Internacional Odontológico
Uruguayo, 17-21 October 2011,
Montevideo, Uruguay
"Potentially malignant disorders; diagnosis
and management", "Lichen planus and
lichenoid lesions; diagnosis and
management", "Oral squamous cell
carcinoma; actual concepts in the diagnosis
and management" and "Unusual squamous
cell carcinomas of the oral mucosa and
some pitfalls"
A two-day international symposium on
"Early diagnosis of oral cancer" at the
Universidad Autónoma Metropolitana
Unidad de Xochimilco (UAMUX), 24 + 25
November 2011, Mexico City, Mexico
Tuberculous meningitis home treatment
program
Servant Leadership Symposium, may 2011,
VU, Amsterdam
Desmond Tutu Chair story
Ethiopic Deledation Symposium, June 2011,
VU, Amsterdam
Meningitis en de gevolgen voor het jonge
kind
KNO symposium, okt 2011, VU, Amsterdam
External validation of a model predicting
hearing loss after childhood bacterial
meningitis
Netherlands
Behavioral functioning of childhood
bacterial meningitis survivors in the
Netherlands
Netherlands
Cost-effectiveness of chemotherapeutic
treatment of childhood acute
lymphoblastic leukemia: the influence of
new medication and diagnostic technology
International society of paediatric oncology
(SIOP 2011), 28-10-2011, Auckland, New
Zealand
van der Kuip M and van
Furth AM
Van der Laken J
Van der Waal I
van Furth AM
van Litsenburg RRL
88
Van Montfrans C
Application of a novel autologous fullthickness skin substitute in hard to heal
chronic ulcers
Portugal
van Moorselaar RJA
Hot News from 2010 Congresses, Prostate
cancer
The 4th World Congress on Controversies in
Urology (CURy), 29 januari 2011, Paris,
France
Cabazitaxel in real life practice. The Dutch
experience
European Expert Board Meeting, 2 juli 2011,
St Petersburg, Rusland
Tour d’Europe: update
European Expert Board Meeting, 2 juli 2011,
St Petersburg, Rusland
Testis cancer: Diagnosis and treatment of
stage I disease
The European Urology Residents Education
Programme (EUREP), 9th EUREP Course, 2-7
September 2011, Prague, Czech Republic
Management of locally advanced and
metastatic disease
The European Urology Residents Education
Programme (EUREP), 9th EUREP Course, 2-7
September 2011, Prague, Czech Republic
Urothelial cancer: Highlights and discussion
Oncoforum summary meeting, 27 November
2011, Amsterdam, NL
Van Schaardenburg D
Predicting rheumatoid arthritis in patients
with seropositive arthralgia
EULAR, May 2011, London
van Well GThJ and van
Furth AM
Host genetic polymorphisms in TLR9 are
associated with the susceptibility and
severity to meningococcal disease
Netherlands
Typing of micro-organismen with TypeNed
WOGIZ in combination with the COM, March
2011, RIVM, Bilthoven
Multi-resistant pathogenes in the hospital
Pulmonologist week ‘Infections and
Tuberculoses’, April 2011, Papendal, Arnhem
Resistance against antibiotics
Delft, Studium Generale, May 2011, Delft
Care for health care acquired infections
Farewell commission prof.dr. P.J. van den
Broek, May 2011, LUmc, Leiden
Facing emerging outbreaks due to MDRpathogens in healthcare
facilities
International Conference on Prevention and
Infection Control (ICPIC), July 2011, Geneve,
Zwitserland
Antimicrobial resistance
Fundashion Mariadal, September 2011,
Bonaire
Prevention and control of antimicrobial
resistance
Boerhaavecursus, October 2011, Leiden
Faculty of Medicine, University of Angers,
October 2011, Angers, France
Resistance in gram negative
microorganismen, in particular ESBL en NDM
Resistente bacteriën op de kinderafdeling:
mediahype of reality show? Nederlandse
Vereniging voor Kindergeneeskunde,
November 2011, Veldhoven
Dag Interne Geneeskunde, Flendrig Lecture,
November 2011, AZM, Maastricht
Science café , November 2011, Nijmegen
EHEC
IC Congres, December 2011, Lunteren
Living with cancer, selfmanagement and ehealth
Symposium Gezondheid op Maat. TNO,
Utrecht, December 1, 2011
Stepped care, selfmanagement, and ehealth in supportive care in cancer, from
hype to trend
Symposium Hospital Psychiatrists, Domus
Medica, Utrecht, November 25, 2011.
Living with cancer and integrated care
Muon symposium. Ede, September 29,
2011
Supportive cancer care, self-management,
and e-health
Study Group Rehabilitation and
Survivorship. MASCC meeting, Athens,
June 24, 2011
89
Leven met kanker
Verdonck-de Leeuw IM. VU Alumni dag.
Amsterdam, May 28, 2011
Living with cancer: innovative care
programs and e-health
Masterclass E-health. Vrije Universiteit,
Amsterdam, February 4, 2011.
Living with cancer
World Cancer Day, Book presentation
Peter Kapitein, AMC, Amsterdam,
February 4, 2011
Leven met kanker: van kennis naar kunde
Regietafel ICT. Jaarbeurs Utrecht,
January 24, 2011
Prevalence of depression in cancer patients
during or after treatment: a meta-analysis
IPOS 13th World Congress of PsychoOncology and Psychosocial Academy,
Antalya, Turkey, October 16-20, 2011
OncoCompass: developing an e-health
management platform to facilitate and
innovate supportive cancer care
Supportive Cancer Care Symposium
MASCC/ISOO 2011, Athens, Griekenland,
June 23-25, 2011.
Prevalence of depression in cancer patients:
a meta-analysis
APOS 8th Annual Conference, Anaheim,
USA, February 19, 2011
A stepped care strategy targeting anxiety
and depression in cancer patients
USA, February 19, 2011
Quality of life as predictor of survival: a
prospective study on patients treated with
combined surgery and radiotherapy for
advanced oral and oropharyngeal cancer
February 19, 2011
Gezond verder met het OncoKompas
Laptoppresenatie op symposium E-mental
health voor somatische aandoeningen,
Nijmegen, April 20, 2011
Objectivering van spraakkwaliteit bij
patiënten behandeld voor hoofd-halskanker
Kopzorgen & Halszaken Congress.
Olympic Stadium, Amsterdam, The
Netherlands, March 25, 2011
A stepped care strategy targeting anxiety
and depression in cancer patients
Head Matters: a guided self-help program
Gezond verder met het OncoKompas
Workshop op congres “Effectiviteit van
interventies”, Nederlandse Vereniging
voor Psychosociale Oncologie, Utrecht,
March 18, 2011
Prevalence of depression in cancer patients
during or after treatment: a meta-analysis
18th NVPO Congress “Effectiveness of
interventions”. Hogeschool Domstad,
Utrecht, The Netherlands, March 18,
2011
Verheul H
Medical Grand Rounds “Mechanisms of
resistance to receptor tyrosine kinase
inhibitors
Rosswell Park Cancer Institute, USA (invited
lecture) March 31, 2011
Visser D and van Furth AM
Is the incidence of tuberculous meningitis
sunlight dependent ?
ESPID, May 2011, The Hague, The
Netherlands
Is the incidence of tuberculous meningitis
sunlight dependent ?
TB Keystone Symposium, Feb 2011,
Vancouver, Canada
ICU malabsorption syndrome
characteristics: fecal energy and
macronutrient losses / Diagnostic accuracy
of faecal weight to identify clinical
significant malabsorption in critically ill
patients
ASPEN, 31 jan 2011, Vancouver, Canada
Assessment of small bowel function in
critically ill MODS patients using the
citrulline generation test
NVGE, 18 march 2011, Veldhoven, The
Netherlands
Malabsorption on ICU
Verpleegkundig symposium Amsterdam, 4 and
7 feb 2011, Amsterdam, The Netherlands
Wierdsma N
90
Windhorst AD
Zweegman S
Malabsorption on ICU
Dietisten dagen 2011, 8 april 2011,
Noordwijkerhout, The Netherlands
New PET radiopharmaceuticals in Oncology
SSPT-USGEB, January 27-28, 2011, Zurich,
Switzerland
Rational design of new tracers
XII Turku PET Symposium, May 28-31, Turku,
Finland
Preclinical evaluation of new PET tracers
EANM, October 15-19, 2011, Birmingham,
England
New PET radiopharmaceuticals in onclogy
EANM, October 15-19, 2011, Birmingham,
England
New Tyrosine Kinase inhibitor PET
radiopharmaceuticals
Seminar November 21, 2011, University of
Helsinki, Finland
Radiopharmaceutical chemistry’
CHAINS2011, November 28, 2011, Maarssen ,
The Netherlands
Revlimid in relapsed refractory Myeloma
Czech Myeloma Group meeting, Slowakia, 151-11
EMNTG; HOVON NMSG what are the current
asked questions?
13th International Myeloma Workingshop
2011, Paris, France, 5-5-2011
The added value of cooperation in Myeloma
Trials in Europe
European Hematology Association London,
England, 9-6-2011
Translating the clinical heterogeneity of
elderly patients into tailored treatment
approaches: tools and therapeutic
strategies
6th European Multiple Myeloma Academy,
Madrid, Spain, 8-10-11
91
Awards
Name
Award
Place and date
De Wilt L
AACR 2011 Aflac Travel Award: $1500
April 4th 2011
De Winter JP
Discovery award for the identification of
FANCP (FA Research Fund)
Barcelona, Spain, October 22, 2011
Fedrigo CA
Award from the International Congress of
Radiation Research Organization
Warsaw, Poland, August 28 – September
1, 2011
Janssen JJWM
Proefschrift van het jaar (Thesis of the year)
Papendal-Arnhem, 27/1/11
Joenje H
lifetime achievement award (FA Research
Fund)
Barcelona, Spain, October 22, 2011
Langius JAE
Biochemical Society Award
2nd International Conference on Cancer
Nutrition Therapy, Edinburgh, Scotland,
March 29-30, 2011
NVO-ESPEN travel grant
NVO meeting, Utrecht, March 15 2011
Pham TV
Poster price: Proteomics of mouse BRCA1deficient mammary tumors identifies DNA
repair proteins with diagnostic and
prognostic value in human breast cancer
Conference: Systems Biology,
Developmental Models and Data
Integration. Dublin. 20-23 juni 2011
Van der Kuip M
ESPID/Wyeth Fellowship Award 2010-2012
Nice, France, May 4-8
Research Masterclass 2
Abstract
nd
price best Dutch
May 2011, The Hague
TULIPS post doc curriculum 2012-13
Utrecht, The Netherlands
Van der Waal I
International Prize of the Spanish Oral
Surgery Society
Official Ceremony of the Sociedad
Espaňola de Cirugía Bucal, Madrid,
Spanje, 16 December 2011
Van Turenhout S
poster of distinction
Digestive Disease Week 2011 Chicago
Vandenbroucke-Grauls CJME
Golden Donders-award received because of
her great efforts and results as chairman of
the board of the NTvG
NTvG, Amsterdam
Veerman AJP
Mas Hidayat, price for ‘’Golden Leadership’’
from the Indonesian Pediatric Association for
20 years of excellent service to sick children
in Indonesia and elsewhere
Manado, Indonesia june 2011/
Yogyakarta september 2011
Veringa S
Studenten Onderzoeks Prijs 2011
6 december 2011
Wojtuszkiewicz A
René Vogels stipendium
11 oktober 2011
Yaqub M
NVNG Woldring price for best thesis in
nuclear medicine
ISALA Klinieken, Locatie Sophia, Zwolle,
26 November 2010
92
Grants obtained in 2011
Project leader(s)
Title project
Funding / budget
Bitter W and Vandenbroucke-Grauls
C
A genome-based generalized strategy to
activate cryptic antibiotic biosynthesis gene
clusters in Actinomycetales
CRYPTON II, STW, technician, 82.000
euro
Boellaard R
QuickConcept
IMI (EU), PhD Student: Like Hoyng,
250.000 euro
Bohlmeijer E, Verdonck-de Leeuw
IM, Drosschaert S
Psychological distress in partners of cancer
patients: efficacy of an online self help
intervention
KWF Dutch Cancer Society, 252.100
euro
Brakenhoff RH
Sister chromatid cohesion as a novel
foothold for cancer therapy
NKB VU 2011-4983 (1 postdoc),
327.000 euro
Brakenhoff RH
MicroRNAs in Head and Neck Cancer
InteRNA (1 postdoc), 100.000 euro
Bultink IEM and Voskuyl AE
Biomarkers in Systemic Lupus
Erythematosus
Educational grant, PhD student: J.
Jacobs, 1.500 euro
Cloos J, Assaraf YG, Jansen G
Unravelling the role of FPGS splicing in MTX
resistance
Rene Vogels Stichting fellowship, PhD
student: Anna Wojtuszkiewicz, 2.700
Euro
De Bree R
Response evaluation after chemoradiation
in advanced oropharyngeal cancer using
PET-CT and MRI
ZonMw 80-82305-97-12010, 125.000
euro
de Winter JP, van Beusechem VW
and Brakenhoff RH
KWF VU2011-4983, Postdoc: Job de
Lange, 327.000 euro
de Winter JP, van Beusechem VW,
Brakenhoff RH
Dutch Cancer Society NKB 2011-4983,
327.000 euro (1 postdoc)
Dekker J, Verheul HMW
Screening and treatment of psychological
distress in colorectal cancer with
metastasized disease: the TES-trial
Alpe d’Huzes/KWF, 521.000 euro
research grant (VU 2011-5279)
Den Otter W
IL-2 therapy of bladder carcinoma
Innovatiefonds, ca 50.000 Euro
Dorsman JC, de Winter JP, Joenje
H
Identification of pathway(s) compensating
for FA pathway defects
FARF pilot study, $ 117.500
Dorsman JC, Te Riele H, Cloos J,
Mol A
Genomics to improve diagnostics and care
of retinoblastoma patients
KIKA, PhD student: Irsan Kooi,
560.000 euro
Gibbs S, Niessen F, Scheper RJ (CEO
A-Skin)
Keloid
AgentschapNL IS (start 2011), PhD
student: Grace Limandjaja, 750.000
euro
Gibbs S, Scheper RJ (CEO A-Skin),
van Hinsberg V
NIRM
FES, 760.000 euro
Hoekstra OS
Meta-analysis of FDG PET in response
evaluation
RSNA QIBA, PhD student: S.N. Rizvi,
75.000 euro
Hoekstra OS
Validation of PERCIST methodology in
pulmonary oncology and FDG PET
RSNA QIBA, PhD student: S.N. Rizvi,
USD 50.000
Hoekstra OS
QuickConcept
IMI(EU), PhD student: V. Frings,
250.000 euro
Huijgens PC, Sonneveld P,
Zweegman S
Imaging side study of the study
“Randomized phase III trial in elderly
patients with previously untreated
symptomatic Multiple Myeloma comparing
MP-Thalidomide (MP-Thal) followed by
thalidomide maintenance versus MPLenalidomide (MP-Len) followed by
maintenance with lenalidomide”
Celgene, 50.000 euro
Huijgens PC, Sonneveld P,
Zweegman S
Extension of the study: “Randomized phase
III trial in elderly patients with previously
untreated symptomatic Multiple Myeloma
comparing MP-Thalidomide (MP-Thal)
followed by thalidomide maintenance
versus MP-Lenalidomide (MP-Len) followed
by maintenance with lenalidomide”
Celgene, 985.000 euro
93
Project leader(s)
Title project
Funding / budget
Hulleman E, Kaspers GJL
Towards novel therapeutics for the
treatment of diffuse intrinsic pontine
glioma (DIPG)
EDLI Foundation, 50.000 euro
Unravelling diffuse pontine glioma (DIPG)
Complete Genomics Sequencing
Grant, 8 samples ~ $ 80.000
Development of in vitro and in vivo mouse
models for diffuse pontine glioma (DIPG)
KiKa grant (project 69), 8 samples ~
269.500 euro
Hulleman E, Wurdinger T
Development of preclinical DIPG imaging
models
KiKa, 250.000 euro (1 PhD student)
Kaspers GJL
Abandonment of childhood cancer
treatment in Kenya: an analysis of causes
and consequences
SIOP International Fellowship
Funding, Postdoc: S. Mostert, 4.000
euro
Kaspers GJL
Compliance with childhood cancer
treatment in Kenya
Stichting Ontwikkelingssamenwerking
VUmc, Postdoc: S. Mostert, 5.000
euro
Kaspers GJL
Compliance with childhood cancer
treatment in Kenya
Lutherse Kerk te Woerden, PhD
student: M.S. Gordijn, 1.700 euro
Kaspers GJL
Noord/Zuid Programma, Postdoc± S.
Mostert, 40.400 euro
Kaspers GJL
Stichting Medicines for Acute
Lymphoblastic Leukemia (SMALL),
Postdoc: S. Mostert, 10.000 euro
Lammertsma AA
FLT-PET imaging to support dose-finding for
the CD-44 program - pre-clinical
qualification in xenograft, part 2
F. Hoffmann-La Roche Ltd, adaptive
study design, budget depending on
actual number of studies performed
Lammertsma AA
Effects of single dose RO5429083 and A2V
treatment on tumor uptake of 11C-docetaxel
in preclinical models
F. Hoffmann-La Roche Ltd, adaptive
study design, budget depending on
actual number of studies performed
Langius JAE, Doornaert P, Leemans
CR
Predictive factors for severe weight loss in
head and neck cancer patients undergoing
radiotherapy and the independent effect of
weight loss on quality of life and survival: a
practical guideline for early identification
and treatment
Cancer Center Amsterdam
Foundation, 100.000 euro
Meuleman EJH
Ontwikkeling van een E-Health Lifestyle
programma voor mannen met de
urogenitale verouderingsklachten LUTS en
ED
Abbott, 95.000 euro
Peters GJ
Mechanism of action of RX3117
Rexahn, NWP
Poot A, van Dongen GAMS,
Windhorst AD
Development of new TKI PET
radiopharmaceuticals
CCA, PhD student: P. Slobbe, 240.000
euro
Rustemeyer T
Low dosis UVB therapy in psoriasis patients
3rd party sponsored, PhD student:
Sylvie Franken, 45.000 euro
Rustemeyer T
Consumers safety CESES
RIVM/VWS, 50.000 euro
Rustemeyer T, Kezic S
Zilver nanoparticles
3rd party sponsored, 30.000 euro
Rustemeyer T, Kezic S
Skin protection
3rd party sponsored, 20.000 euro
Schuurhuis GJ, Ossenkoppele GJ
Minimal residual Disease in AML
HOVON (industrial), 150.000 euro,
PhD student (in part): Wendelien
Zeijlemaker
Smit L, Schuurhuis GJ,
Ossenkoppele GJ, Huijgens P
Het ontwikkelen van een therapie gericht
tegen het uitroeien van de cellen die
leukemie veroorzaken, de leukemische
stamcellen
Stichting Leukemia, 10.000 euro
Smit L, Schuurhuis GJ,
Ossenkoppele GJ, Ylstra B, Menezes
R
Target identification specific for leukemic
stem cells of Acute Myeloid Leukemia
CCA/V-ICI 2011, 275.000 euro, PhD
student Han Verhagen
Taphoorn MJB, Heimans JJ,
Reijneveld JC
Quality of Life and the End of Life phase in
glioma patients
Clinical research/postdoc, Stichting
Devon Den Haag, 1.0 fte senior
researcher (4 years)
94
Project leader(s)
Title project
Funding / budget
Taphoorn MJB, Klein M
The impact of tumour treatment on
cognitive functions in brain tumour patients
Clinical research/ neuropsychology,
Jacobus Stichting Den Haag, 0.4 fte
neuropsychologist (3 years), PhD
student: E. Habets, MSc
van Bergen en Henegouwen P,
Wurdinger T
Development of EGFRvIII targeted
immunotoxins
Stophersentumoren.nl2011, 100.000
euro (1 technician)
van Bokhorst- van der Schueren
MAE, Verheul HMW, Langius JAE
Does nutritional intervention of patients
with precachexia undergoing chemotherapy
improve nutritional status, quality of life
and treatment outcome?
Dutch Cancer Society, grant VU 20115262, PhD student: S. Buskermolen,
510.600 euro
Van der Vliet H
Promoting antitumor immunity by specific
tumor targeting of iNKT cells
ZonMW, 160.000 euro
Van der Vliet H
Specific tumor targeting of iNKT cells and
Vy9Vo2 T cells using nanobody technology
Dutch Cancer Society, VU2010-4728,
799.900euro
Van der Vliet H, Verheul HMW
Phase 1-2 study of everolimus and low-dose
oral cyclophosphamide in patients with
metastatic renal cell cancer
KWF clinical trial grant, 184.000 euro
Van der Vliet H, Verheul HMW
Preclinical BEZ235NCZVUMC01
Novartis, €20.800,-
van den Berg M, van Dulmen-den
Broeder E, ter Kuile M, Hilders C
Practice, Attitude and Knowledge regarding
fertility preservation techniques in the
Netherlands (the PAK-study)
KiKa (Projectnummer 78) and DSW,
PhD student: Annelies Overbeek
(VUmc) / Leoni Louwé (LUMC), 34.431
euro (KiKa) + 25.000 euro (DSW)
Fund raising for the organisation of the
Reumabeweegdag 2011 Amsterdam
40.000 euro
Van Furth AM
program
UBS Optimum Fund, 118.000 euro
Van Furth AM
program
Lions Noordwijk, 60.000 euro
Van Furth AM
program
Mr Willem Backhuys Roozeboom
Stichting, 25.000 euro
Van Furth AM
Neonatal Infections
Nuts Ohra, 225.000 euro
van Furth AM, Reinceke C
Metabolomics study of tuberculous
meningitis in children
Desmond Tutu Program, VU,
Amsterdam, PhD student: Shayne
Mason. 90.000 euro
van Furth AM, Schoeman J
Improving early diagnosis of tuberculous
meningitis
Desmond Tutu Program, VU,
Amsterdam. PhD student: Regan
Solomons. 90.000 euro
Van Moorselaar RJA
Intraprostatic androgen assessment as a
diagnostic (and prognostic) tool
Astellas, PhD student: vd Sluis,
100.000 euro
Van Moorselaar RJA
Immediate vs later intravesical Mitomycin C
instillation for nin-muscle invasive bladder
cancer. A multicenter open-label
randomised phase III study
Nycomed/Kyowa, 66.000 euro
van Tellingen O, Wurdinger T
Promising drug combinations in the
treatment of high-grade glioma
Stophersentumoren.nl2011, 150.000
euro (1 technician)
Van Tuyl L
Patient perspecitve in RA remission
EULAR, 80.000 euro
Van Tuyl L
The patient perspective on Rheumatoid
Arthritis
EULAR research grant, 74.000 eur
Living with cancer: innovative care
programs and e-health
KWF Dutch Cancer Society / Alpe
d’HuZes (2011-2013) (postdoc: C.F.
van Uden-Kraan), 196.000 euro
Verdonck-de Leeuw IM, Eerenstein
S, Leemans CR, de Bree R
LARiNX: a web-based self-help programme
for laryngectomized patients during and
after treatment
Michel Keijzer Foundation, PhD
student: Ingrid Cnossen, 199.600 euro
Verdonck-de Leeuw IM, Ganzevoort
R, Delver J
Spiritual Autobiographic writing for cancer
patients
Addessium Foundation / RCOAK, PhD
student: Lenneke Post, 175.500 euro
Verheul, H.M.W.
Diagnotic tools to predict whether a patient
will develop toxicity to cetuximab
Merck Serono, 50.000euro
95
Project leader(s)
Title project
Funding / budget
Verheul HMW
OPL mass spectrometer
Stg Moller Foundation, 200.000 euro
Verheul HMW / Jimenez C
OPL mass spectrometer
Rabobank, 300.000 euro
Verheul HMW / Jimenez C
Histopathologic and Mechanistic Assessment
of Angiogenesis Inhibitor Related Toxicities
7th Framework programme of the EU,
310.000 euro
Vis A
Beslishulp voor mannen bij de keuze van
een behandeling voor lokaal beperkt
prostaatkanker
Ipsen, ca 30.000 euro
Vos J, Tollenaar R (LUMC),
The development, implementation and
evaluation of the meaning-centered group
psychotherapy 'Living Meaningfully with
Cancer' in the Netherlands
KWF Dutch Cancer Society, PhD
student: Nadia van der Spek, 596.500
euro
Voskuyl AE
Development and manitenance of a longterm national patient outcomes registry for
systemic lupus erythmatosus in the
Netherlands- The PORSLEN registry
GlaxoSmithKline, 592.000 euro
96
Meeting organization
Project leader(s)
Meeting
Place / date
Bitter W
NvMM/NvvM voorjaarsvergadering
19-21 April, Papendal, Nederland
Boellaard R
MIRO 212
March 2012, Vienna
Brakenhoff RH
Course Oncogenesis, Research Master
Oncology
VU/VUmc
De Bree R, Leemans CR, Eerenstein
SJE
4th European Head & Neck Course
Amsterdam, 5-7 oktober 2011
de Winter JP, Dorsman JC, Waisfisz
Q, Oostra AO and Akse D
Symposium in honour of the retirement of
Prof. dr. H. Joenje: “DNA instability, cancer
and aging”
Amsterdam, 16 March, 2011
Dekker J
Member of the program committee of the
12th International Congress of Behavioral
Medicine
August 2012, Budapest, Hungary
Gibbs S
ETRS
5-7 October 2011, Amsterdam, Nederland
Sens-it-iv end symposium for Stakeholders
Hensen EF
Hulleman E, Jansen M, van Vuurden
D
Jimenez CR
e
2 Symposium slechthorendheid bij het
jonge kind. Gehoorverlies na meningitis:
diagnostiek, preventie en behandeling
NEMO Amsterdam, 12 oktober 2011
8e Patientendag Nederlandse vereniging voor
patiënten met paragangliomen (NVPG)
VU academisch medisch centrum,
DIPG meeting Amsterdam
14-15 January 2011, Amsterdam
Cancer Proteomics 2011: Systems Biology,
Developmental Models and Data Integration
Dublin. 20-23 juni 2011
ENP 2011, CSF proteomics
Lunteren, 30 mei 2011
Co-organisor, Fall meeting Netherlands
Proteomics Platform
Oct 28, 2011, Leiden
Second Workshop on Pediatric Oncology
11-12 January 2011, Eldoret, Kenya
Workshop on Pediatric Leukemia
30 September and 1 October 2011,
Ygyakarta, Indonesia
Annual meetıng of the American Society of
Hematology (scientific committee on
Lymphoid Neoplasia)
December 2011, San Diego, USA
Kluytmans JAJW
2nd ASMET – The ASM Emerging Technologies
Conference
8 – 11 maart 2011, San Juan, Puerto Rico
Peters GJ
EACR-meeting on Drug Development
October 2011, Antalya, Turkey
EORTC-PAMM Winter meeting
Sopot, Poland,
Dermatologendagen
18 – 19 March 2011, Papendaal, The
Netherlands
Themadag Dermatologie
18 September 2011, Utrecht, The
Netherlands
PMS Cosmetica
21 April 2011, Amersfoort, The Netherlands
Contiunuum Dermatologica
08 December 2011, UItrecht, The
Netherlands
Kaspers GJL
Rustemeyer T
Savelkoul PHM
Cursus Typeren
24/25/26 January, Utrecht
Sminia P
Member of the Organizing Committee of the
International meeting of the Dutch Society
for Radiobiology (NVRB)
Noordwijkerhout, April 19-20, 2012
Diagnosis and Treatment of (axial)
Spondyloarthritis
Charite Hospital, 1 April, 2011 (Berlin)
Wetenschappelijke congressen Ned Ver
voor Reumachirurgie (NERASS ) :
Lustrumcongres: samen sterk voor arthritis
9 sept, Scheveningen
97
en artrose
van der Laken J
regional MRI education for rheumatologists
Van der Waal I
European Meeting on Oral Diseases.
Diagnosis and Management
11-13 May 2011, Amsterdam, The
Netherlands
Existential issues in cancer: who cares?
19-1-2011, Amsterdam
Kopzorgen en halszaken (innovative
supportive care in head and neck cancer)
25-3-2011, Amsterdam
Voskuyl AE
Najaarsdagen reumatologie NVR
September 2011, Papendal
Windhorst AD
International Symposium on
Radiopharmaceutical Sciences
August 28 – September 2, 2011, Amsterdam,
The Netherlands
98
News
C.R. Jimenez:
• 19 feb. 2011. Diario Medico. ‘Ahora es el turno de las proteinas’
• 9 sept. 2011. Tracer. Eiwitten verraden darmkanker
• 15 sept. 2011. Ad Valvas. Eiwitten en darmkanker
• 25 sept. 2011, OncoPost, the daily journal of The 2011 Multidisciplinary European Cancer Congress.
The language of proteins: understanding proteins today can change cancer therapy tomorrow
S. Gibbs:
• promovendus Krista Ouwehand Kunsthuid voor alergieonderzoek. Telegraph 11 January 2011
• promovendus Krista Ouwehand Allergieonderzoek straks niet meer op proefdieren. Metro 4 January
2011
T. Rustemeyer
• Effectieve thuisbehandeling tegen zonneallergie ontwikkeld. Volkskrant − 23/05/11
• Zonneallergie. Telegraaf 25-03-2011
• Effectieve thuisbehandeling tegen zonneallergie ontwikkeld. Trouw 25-05-2011
• Zonneallergie en behandeling. RTL nieuws 23-05-2011
• Ziekenhuizen zien explosie aan hooikoortsklachten. Volkskrant 28-04-2011
I.E. van der Horst-Bruinsma
• bijlage Telegraaf (sept 2011): Botten en gewrichten: samenwerking reumatoloog en orhopedisch
chirurg
• bijlage NRC-handelsblad (dec 2011): Botten en gewrichten: invloed van extra-articulaire manifestaties
op de ziekte van Bechterew
99
100
Appendix 6: Societal impact
Appendix 6: Societal Impact
Social-cultural relevance
Professional publications and products
Jimenez CR
Lekenpublicatie ‘Eiwitten op darmcellen markeren gevaarlijke voorstadia
darmkanker’ Oncologie Up-to-date | 2011 • vol 2 • nummer 6
Lekenpublicatie: Oncoproteomics: systeembiologie, ontwikkelingsmodellen en
data-integratie. Oncologie Up-to-date | 2011 • vol 2 • nummer 5
Peters GJ, Ichida K
Guest Editors of Nucleosides, Nucleotides and Nucleic Acids , a special issue
on PP11, the 14th International Purine and Pyrimidine Symposium (Vol 30;
issue 12, pp. 999-1340, 2011)
Memberships of an advice council in the public field
Bultink IEM
Membership of the medical advice council of the “Nationale vereniging voor
lupus, sclerodermie en MCTD patiënten (NVLE)”
Membership of the steering committee of the Dutch network for “Patient
research partners in Rheumatology”.
Medical advisor of the local patient department of the Dutch Arthritis
Foundation (“Reuma patiëntenvereniging Amstelland en omstreken”)
Dekker J
Member of Committee Social Oncology, Dutch Cancer Society- KWF
Kaspers GJL
Participation in Doctor2Doctor, a collaboration between VU University
Medical Center and KLM Aircares on the one hand, and Moi Teaching &
Referral Hospital, Eldoret, Kenya on the
other hand
Peters GJ
Member of the scientific advisory board, “Cancéropôle Lyon-Auvergne-RhôneAlpes”, Lyon, France
Member review committee for TCRF and ACS grants, UICC, Geneva,
Switzerland
Translational Research Committee, Institut National du Cancer, Paris, France
Equipment of excellence, Agence National de la Recherche, Paris, France
Rustemeyer T
EU commission on Consumers´ HealthVWS en VWA
Arbo Expert Groep NederlandVWS
Cosmetica en consumentenveiligheidVWS, RIVM
Slotman B
Member commission Radiotherapie Gezondheidsraad
Chairman Taskforce Radiotherapie
Member CvB, Nederlandse Vereniging Radiotherapie en Oncologie
Van Beusechem VW
Member, user committee ZonMw Translational Gene Therapeutic Research
project on “oncolytic adenovirus therapy as a neoadjuvant treatment for
localized prostate cancer” at Erasmus Medical Center, Rotterdam, The
Netherlands
Member, user committee Technology Foundation STW project on “Directed
evolution of artificial viruses” at University of Utrecht, Utrecht, The
Netherlands
Voskuyl AE
Het Reumafonds : advisory board/ scientific committee
NVLE (patient league) : president Medisch Advies Raad
Indications in a directive, protocol or policy note
Kirtschig G
Richtlijnencommissien `Lichen sclerosus en Lichen planus` (member on
behalf of the NVDV)
101
Evidence-based (S3) guideline on topical corticosteroids in pregnancy on
behalf of the EDF (European Dermatology Forum) (Br J Dermatol. 2011
Nov;165(5):943-52. Epub 2011 Sep 29. Chi CC, Kirtschig G, Aberer W et al.)
Guideline Committee for the management of bullous pemphigoid on behalf of
the British Association of Dermatologists
Guideline Committee on vulval Lichen Planus on behalf of the BSSVD (British
Society for the Study of Vulval Disease)
Rustemeijer T
Richtlijnencommissien `Lichen sclerosus` (member on behalf of the NVDV and
the NVVA)
Richtlijnencommissie `Contacteczeem` (chairperson on behalf of the NVDV
and the NVVA)
Richtlijnencommissie `Koemelkallergie` (member on behalf of the NVVA)
Media attention
De Wilt L
Interviewed by oncologie TV at the WCLC 2011, RAI, Amsterdam
Dept. MMI
Labyrint: Antibiotica en resistentie, 02-02-2011
Teleac Helder: Antibioticaresistentie bij mensen door het eten van kip, 23-022011
NOS Journaal: Ook resistente bacteriën gevonden in groente, 18-04-2011
WRD: Markt Gemüse: Resistente Bakterien, 16-05-2011
WNL: Uitgesproken NL: Boer gebruikt probiotica om ziekten bij dieren te
voorkomen, 08-06-2011
TROS: Tros Radar: Antibiotica in de veehouderij , 05-09-2011
Gibbs S
Mens & Lichaam: De beste pleister op de wond? Die wordt gemaakt van je
eigen huidcellen. Quest – DPTE. Tekst: Berry Overvelde. (2011)
Interview Daphne Bunskoek met Irma Verdonck over leven met kanker. TVuitzending Gesprek op 2. 30 oktober 2011
5 vragen over het nieuwe OncoKompas. Interview tijdschrift Pink Ribbon,
oktober 2011, pagina 10
Erkenning van en aandacht voor leven met kanker. Interview Tijdschrift
Medische Oncologie 2011,14,5:36-38
OncoKompas, geïntegreerde zorgcoördinatie door eHealth. VUmc Nieuwsbrief
voor verwijzers, themanummer soma-psyche, juni 2011
De kunst van het leven. Interview Tijdschrift “Leven het leven” VUmc / CCA
Tijdgeesten - Radio-uitzending Wereld Omroep, 29 mei 2011
Koffietijd. TV uitzending RTL4, 15 februari 2011
Würdinger T
Blood publication media attention: Most Dutch newspapers, and NOS (TV), RTL
Nieuws (TV)
Perceptible impact on public informing and/or authoritative websites
Gibbs S
www.sens-it-iv.eu
www.A-skin.nl
www.mucosa.nl
www.NECOD.nl
www.vumc.nl
www.beroepsziekten.nl
Sminia P
102
Member of the “Denktank” of the Stichting Hersentumor.nl, impact on public
informing website (www.hersentumor.nl)
Organisation of Reumabeweegdag Amsterdam, 29th October, Sporthallen
Zuid , 400 participants
2011 Adviseur Reumapatientenbond mbt ontwikkeling Kwaliteitscriteria voor
de Reumazorg
Nascholing huisartsen, 28 nov Amsterdam
Nationale projectleider Patient Partners, waarbij getrainde reumapatiënten
onderwijs geven aan artsen en studenten mbt reumatoïde artritis
Medical advisor patiëntenorganisatie “Stichting Bechtrew in Beweging”
2011 ALV Reumafonds
Referent ZONMW en Reumafonds
Release public website www.samenlevenmetkanker.nl
Release public website www.oncokompas.nl
Perceptible impact on public opinion and/or political decision-making
Rustemeyer T
EU commission on Consumers´ Health (scientific expert), VWS, RIFM en VWA
(scientific expert)
Technical or economic impact
Memberships of an advice council in the commercial field
Peters GJ
member of the scientific advisory board, Heidelberg Pharma GmbH,
Ladenburg, Germany
member of the scientific advisory board, Kucera Pharmaceuticals, WinstonSalem, NC, USA
member of the scientific advisory board, Clavis Pharma, Stockholm, Norway
member of the scientific advisory committee, Clovis Oncology, San Francisco,
CA, USA
member of the scientific advisory committee, Spectrum Pharmaceuticals,
Irvine, CA, USA
Van Beusechem VW
Chief Scientific Officer, ORCA Therapeutics BV
Voskuyl AE
Roche, Actelion, BMS
Patent applications
Brakenhoff RH
One patent application with InteRNA, “Het verschil” Cancer Centrum
Amsterdam
Gibbs S
Patent: Title “bioengineered skin regeneration”, Priority: January, 16 2004,
PCT/NL2004/00039, tender date: January 14, 2005. Renewed application nr:
PCT/NL2005/000026. Tender date changed claims: March 7, 2008.
International publication number: WO 2005/068614 A2, date: July 28, 2005.
Patent registration P26915, filed 2005. publication: 11 October 2006,
European publication number: 1709160. Text Patent application: A method
for in vitro growing of an autologous dermal tissue sub-stitute of a subject,
said dermal tissue substitute being populated with fibroblasts and keratinocyts. Patent is related to constructing method of skin substitute and the
application of the connective tissue substitute for treating wounds. The PCT
application consists of 24 claims. On the basis of the written opinion of the
European patentability of the Tiscover®-claims the application has been
changed slightly. After rewriting some of the claims the opinion was: All
claims are novel, innovative and applicable. Renewed claims were filed on
February 28, 2006. The opinion is that all claims are found novel, innovative
and applicable. Examiner makes small remarks on patentability of skin
substitute with national patent offices. The patent has been filed in EU, USA,
Canada, Australia and Japan in 2011.
103
Jimenez CR
Protein biomarkers for detection of colorectal cancer (CRC). Inventors: L.J.W.
Bosch, M. de Wit, B. Carvalho, R.J.A. Fijneman, G.A. Meijer, C.R. Jimenez,
S.R. Piersma, T. .V. Pham, G. Oudgenoeg
Protein markers and BRCAness signature for identification of patients with
homology repair deficiencies and stratification for DNA damaging therapy.
Inventors: C.R. Jimenez, M.O. Warmoes, T.V.Pham, S. Rottenberg (NKI), J.
Jonkers (NKI)
Schuurhuis GJ
Stem cell kit for acute myeloid leukemia
Van Beusechem VW
6 active patent families in 2011
2 European patents granted in 2011
1 US patent issued in 2011
Würdinger T
Holder of 3 Thrombocyte RNA analysis provisional patents and patent licenses
Spin off” start-ups
Gibbs S
CSO of A-Skin BV (see www.A-skin.nl)
CSO of Mucosa BV (see www.mucosa.nl)
104
Appendix 7: Ongoing projects
Program 1
Characterization of DNA stability genes and other cancer predisposition genes
1. Characterization of DNA stability genes and other cancer predisposition genes
M. Adank, S. Agarwal, N. Ameziane, S.T. Bakker, J.L. Bakker, J.A. Balk, M. Corbin, A. Faramarz, M., A. Haitjema, E.I.
Kooi, J. de Lange, Massink, S. van Mil, B. Mol, A.B. Oostra, D. Rockx, K. Roohollahi, M.A. Rooimans, C. Stoepker, C.J.
Dommering, J.J.P. Gille, F.H. Menko, Q. Waisfisz, J.C. Dorsman, H. Joenje, H. Meijers-Heijboer, J.P. de Winter
Dept. of Clinical Genetics, VU University Medical Center, Amsterdam
Dutch Cancer Society (NKI 2006-3589, VU2011-4983, VU2010-4767); FARF; KIKA; NWO (ALW 817.02.018, TOP-GO
854.10.013); CCA/V-ICI, Avanti/STR, EC
2. Fanconi anemia: a genomics approach
A. Haitjema, D.A. Rockx, B. Brand, N. Ameziane, J.P. de Winter, H. Joenje, J.C. Dorsman
Department of Clinical Genetics, VU University Medical Center, Amsterdam
Fanconi Anemia Research Fund, Eugene, Oregon, USA
3. Genomic profiles for inherited breast cancer
M. Massink, J.P. de Winter, Q. Waisfisz, H. Meijers-Heijboer
NWO VIDI Meijers-Heijboer
4. Genomics to improve diagnostics and care of retinoblastoma patients
Kooi EI1, Dorsman JC1, Cloos J2, Moll A3, te Riele H4
Dept. Of 1Clinical Genetics, 2Pediatric Oncology/Hematology, 3Ophthalmology, VU University Medical Center, 4Dept.
Molecular Biology, NKI, Amsterdam
KIKA
5. Human genes essential for the defence against oxygen toxicity
M. Corbin, D.A. Rockx, A.B. Oostra, A. Avan, K. Roohollahi, H. van Beek, H. Joenje, J.C. Dorsman
NWO Mozaïek and Fanconi Anemia Research Fund, Eugene, Oregon, USA
6. Identification of novel players in the Fanconi anemia pathway
N. Ameziane1, J.C. Dorsman1, J.T. den Dunnen2, J.P. de Winter1
1Department of Clinical Genetics, VU University Medical Center, Amsterdam, 2Department Human and Clinical Genetics,
LUMC Leiden
KWF VU2010-4767
7. Identification of pathway(s) compensating for Fanconi anemia gene defects
A. Haitjema, D.A. Rockx, B. Brand, N. Ameziane, J.P. de Winter, H. Joenje, J.C. Dorsman
Fanconi Anemia Research Fund, Eugene, Oregon, USA
8. Regulation of replication-coupled DNA maintenance
S. Agarwal, J.P. de Winter
Dept. of Clinical Genetics, VU University Medical Center Amsterdam
ALW 817.02.018
9. Significance of the Fanconi anemia caretaker pathway in development and treatment of cancer
S.T. Bakker1, M.A. Rooimans2, , A.B. Oostra2, H. Joenje2, J.P. de Winter2, H. te Riele1
1Molecular Biology, The Netherlands Cancer Institute, Amsterdam, 2Department of Clinical Genetics VU University
Medical Center
KWF NKI 2006-3589
10. Sister chromatid cohesion as a novel foothold for cancer therapy
J. de Lange1, RH Brakenhoff2, VW Van Beusechem3, J de Winter1
Department of Clinical genetics and 2Department of Otolaryngology/Head-Neck Surgery, 3Medical Oncology, VU
University Medical Center
NKB VU 2011-4983
11. Sister chromatid cohesion: lessons from yeast, mice and men
A. Faramarz1, H. van Attikum2, H.te Riele3, J.P. de Winter1
1Department of Clinical Genetics, VU University Medical Center, Amsterdam, 2Department Toxicogenetics, LUMC
Leiden, 3Molecular Biology, The Netherlands Cancer Institute, Amsterdam
NWO TOP-GO 854.10.013
12. The Fanconi anemial/BRCA pathway in head and neck squamous cell carcinomas
C. Stoepker1, N. Ameziane1, P. van de Lelij1, J.A. Balk1, A.B. Oostra1, M.A. Rooimans1, J. Steltenpool1, S. Martens-de
Kemp2, R.H. Brakenhoff2, H. Joenje1, J.P. de Winter1
1Department of Clinical genetics and 2Department of Otolaryngology/Head-Neck Surgery, VU University Medical Center
CCA/V-ICI
13. The molecular carcinogenesis of retinoblastoma
B.M. Mol1, E.I. Kooi1, A.C. Moll2, D.A.P. Rockx1, W.A Kors3, M.I. Bosscha2, C. Dommering1, H. Joenje1, H. te Riele5, J.
Cloos3,4, J.C. Dorsman1
Department of 1Clinical Genetics, 2Ophthalmology, 3Pediatric Oncology/Hematology, 4Hematology VU University
Medical Center, Amsterdam and 5Molecular Biology, The Netherlands Cancer Institute, Amsterdam
CCA/V-ICI Stichting Avantie STR (round 2008)
14. Towards targeted treatment of (familial) breast cancer
J. Bakker1, S. van Mil1, A.B. Oostra1, H. Verheul2, H. Meijers-Heijboer1, J.P. de Winter1, Q. Waisfisz1
Department of Clinical Genetics, Division Oncogenetics, and 2Department of Medical Oncology, VUmc
CCA/V-ICI
Colorectal cancer
15. Clinical and biological relevance of focal deletions in colorectal cancer
105
O. Krijgsman1, G.A. Meijer1, B. Carvalho1, R.D. Steenbergen1, B. Ylstra1
Dept. of Pathology, VU University Medical Center, Amsterdam
Stichting Avanti STR
16. Data mining DNA copy number changes in cancer
A.I. Scheinin, B. Ylstra, S. Knuutila, G.A. Meijer
Dept. Of Pathology, VU University Medical Center, Amsterdam
17. Datamanagement voor moleculaire vroegdiagnostiek en therapieselectie bij darmkanker
J. Beliën, G.A. Meijer
18. Development of an improved molecular test for population-wide colorectal cancer screening
A.C. Hiemstra, B. Carvalho, R.J.A. Fijneman, C.R. Jimenez, C.J. Mulder, G.A. Meijer
Dept. of Pathology, Medical Oncology and Gastroenterology, VU University Medical Center, Amsterdam
Vrienden van het CCA
19. Development of screening tests for early detection of CRC
L. Bosch1, B. Carvalho1, M. van der Wiel1, V. Coupé1, M. van Engeland4 Y. van der Burgt5, W. van Criekinge6, C.R.
Jimenez2, R. Fijneman1, C.J. Mulder3, G.A. Meijer1
1Dept. Of Pathology, 2Dept. Medical Oncology (OncoProteomics Laboratory), 3Dept. Gastroenterology, VU University
Medical Center, 4MUMC, 5LUMC, MdXHEalth, 6Univ Gent
CTMM
20. Early detection of colorectal cancer by faeces derived microRNA testing
L. Timmer1, B. Diosdado1, E. Cuppen2, G.A. Meijer1
Dept. Of Pathology1, VU University Medical Center, Amsterdam, Hubrecht Laboratorium Utrecht2
KWF VU 2009-4276
21. Early detection of colorectal cancer by faeces derived microRNA testing
G.A. Meijer, B. Diosdado, R.Q.J. Schaapveld
Dept. Of 1Pathology, VU University Medical Center, 2InteRNA Technologies BV
inteRNA
22. Improving FOBT based colorectal cancer screening by faeces DNA testing
G.A. Meijer1, M. van Engeland2
Dept. Of Pathology, VU University Medical Center Amsterdam1, MUMC Maastricht2
ZonMw
23. Structural chromosomal rearrangements in colorectal cancer
E. van den Broek, R.J.A. Fijneman, G.A. Meijer
V-ICI
Detection and treatment of oral preneoplasia
24. Diagnosis and therapy of genetically altered mucosal lesions in the oral cavity and oropharynx
A.P. Graveland1, A. Brink1,2, E. Bloemena3, B.J.M. Braakhuis1, C.R. Leemans1, I. van der Waal2, R.H. Brakenhoff1
Depts of 1Otolaryngology/Head-Neck Surgery, 2Oral and Maxillofacial Surgery and 3Pathology, VU University Medical
Center
FARF, Avanti STR Foundation
25. Fanconi anemia: course of disease in the Dutch patient cohort and early recognition of cancer
S. Smetsers1,3, Brakenhoff RH1, H. Joenje1, J.C. Dorsman1, C.M. Zwaan2, M. Bierings3
3University Medical Centre Utrecht, Erasmus MC/2Sophia Children’s Hospital Rotterdam; 1Department of Clinical
Genetics, VU University Medical Center, Amsterdam
Kika
EBV
26. EBV non-coding RNAs hijack components of the miRNA machinery promoting viral oncogenesis
D. Koppers-Lalic, J.M. Middeldorp, G. Scheffer, R.J. Scheper, C.R. Jimenez, D.M. Pegtel
Department of Pathology, VU University Medical Center
AICR 11-0157
27. Role of the soluble viral BARF1 oncoprotein in Epstein-Barr virus-driven carcinogenesis and its functional inhibition
by antibodies
A.E. Greijer, J.M. Middeldorp
KWF 2007-3776
28. Screening for early stage NPC in high risk regions in Yogyuakarta
S.H. Hutajulu2, S.M. Haryana, J.M. Middeldorp1
Dept. Of 1Pathology, VU University Medical Center, 2UGM, Yogyakarta, Indonesia
NWO-Nuffic
EBV oncogenesis
29. Physiological role of EBV-LMP1 in MHC-II+exosomes for tumor immune escape across the immunological synaps:
Implications for prognosis and immunotherapy
F. Verweij, E. Hooijberg, J.J.C. Neefjes, J.M. Middeldorp, D.M. Pegtel
KWF 2007-3775
Head and neck cancer predisposition
30. Genetic characterization of HNSCC of young adults
B.J.M. Braakhuis1, R.H. Brakenhoff1
1Sect. Tumor Biol, Dept. Otolaryngol/Head-Neck Surg
Intramural support
31. High sensitivity to DNA damage in the aetiology of head and neck squamous cell carcinoma in young adults and
individuals not exposed to tobacco smoke and excessive alcohol (SenseDNA)
B.J.M. Braakhuis1, H. Joenje2, A. Nieuwint2, P. Graveland1, G. Flach1, R.H. Brakenhoff1
106
1Section Tumor Biol, Dept. of Otolaryngology/Head-Neck Surg, 2Dept of Clin Gen, VU University Medical Center,
Amster¬dam, and 4Dept. Biomolecular Mass Spectrometry, University Utrecht
Intramural support
Head and neck carcinogenesis and cancer genes
32. Clinical significance of human papillomavirus infection in oropharyngeal squamous cell carcinoma
M. Rietbergen, C.R. Leemans, P.J.F. Snijders, B.J.M. Braakhuis, E. Bloemena, R.H. Brakenhoff
1Dept Otolaryngology/Head-Neck Surgery and dept. of Pathology, VU University Medical Center
KWF grant VU 2009-4531
33. Functional characterization of TP53 mutations in head and neck squamous cell carcinoma, and association with
clinical outcome
Technician, R.H. Brakenhoff, C.R. Leemans, M. Buize, B.J.M. Braakhuis
Dept Otolaryngology/Head-Neck Surgery, VU University Medical Center, VU University Medical Center, Amsterdam
34. Identification of oncogenic microRNAs and cancer genes involved in head and neck squamous cell carcinoma by a
functional genomics approach
M. van der Plas, B.J.M. Braakhuis, C.R. Leemans, R.H. Brakenhoff
Section Tumor Biology, Dept. of Otolaryngology/Head-Neck Surgery, VU University Medical Center, Amsterdam
CCA/V-ICI, Avanti STR Roundation, InteRNA 2009-4531
HPV-induced tumors
35. Clinical evaluation of methyulation markers for risk assessment of high-risk HPV-positive women for cervical cancer
and its high grade precursors
L. de Strooper, C.J.L.M. Meijer, P.J.F. Snijders, D.A.M. Heideman
Dept. Of Pathology, VU University Medical Center Amsterdam
KWF 2009-4522
36. Comprehensive analysis of the long-term oncogenic capacity and in vitro transforming property of the 15 high-risk
human papillomavirus types
D.M. Schütze, R. van Baars, J. van der Marel, P.J.F. Snijders, R.D.M. Steenbergen, W. Quint, C.J.L.M. Meijer
HUMAVAC
37. Comprehensive molecular characterisation of a longitudinal in vitro model of high-risk HPV-mediated
transformation
V. Miok1, S.M. Wilting1, R.D.M. Steenbergen1, W.N. van Wieringen2, P.J.F. Snijders1
Dept. Pathology1 and Epidemiology & Biostatistics2, VU University Medical Center Amsterdam
St. VUmc CCA
38. Defining the essential molecular pathways involved in cervical carcinogenesis
F.E. Henken, P.J.F. Snijders, D.A.M. Heideman, C.J.L.M. Meijer, R.D.M. Steenbergen
CCA/V-ICI
39. Genetic profiling of CIN 3 lesions diagnosed in the subsequent screening round following screening by HPV testing
and cytology
M. Bierkens, R.D.M. Steenbergen, D.A.M. Heideman, C.J.L.M. Meijer, P.J.F. Snijders
CCA/V-ICI
40. Health-economic modelling of prevention strategies for HPV-related diseases in European countries
H. Berkhof, C.J.L.M. Meijer
Dept. of Pathology and Biostatistiek&Epidemiologie, VU University Medical Center, Amsterdam
EU
41. HPV vaccination
M. Mollers, M. Scherpenisse, C.J.L.M. Meijer
RIVM
42. Identification and clinical validation of methylation markers for cervical adenocarcinomas and their precursor
lesions
S. Snellenberg, C.J.L.M. Meijer, P.J.F. Snijders, R.D.M. Steenbergen
KWF 2007-3771
HPV-induced tumors
43. Identification of miRNAs and other ncRNAs as biomarkers for cervical cancer and assessment of their potential
functional relevance in HPV-mediated transformation
S.Wilting , P.J.F. Snijders, R.D.M. Steenbergen
44. Improving detection-efficiency of CIN3+ in non responder-women that test positive for hrHPV in a self-collected
sample: design of PROTHECT 3 trial
F. van Kemenade1, D.A.M. Heideman1, P.J.F. Snijders1, M. van Baal2, L. Masuger3, R. Bekkers3, W. Melchers4, R. Hol5
Dept. Of Pathology1 and Gynaecology2, VU University Medical Center Amsterdam, Dept. Gynaecology, UMCN3, Mol.
Diagnostics, UMCN4, Delphi Biosciences5
St. Bevolkingsonderzoek midden-west
45. Profiling of aberrant microRNA methylation events that are functionally relevant during cervical carcinogenesis
S.M. Wilting, R.D.M. Steenbergen, P.J.F. Snijders
Dept. Of Pathology, VU University Medical Center
KWF 2010-4668
46. Self screen: biomarker-based companion diagnostic of HPV positive woman to detect cervical cancer
D.A.M. Heideman, P.J.F. Snijders, R.D.M. Steenbergen, C.J.L.M. Meijer
Department of Pathology, VU University Hospital Amsterdam
ZonMw
107
47. Simplified monitoring post-treatment CIN 2/3 women by molecular testing for hrHPV and methylation markers
M. Uijterwaal1, C.J.L.M. Meijer1, Th.J.M Helmerhorst2, R.D.M. Steenbergen1
1VU University Medical Center, Amsterdam, 2Erasmus University Medical Center, Rotterdam
KWF 2009-4413
48. Stratifying high-risk HPV positive women for risk of CIN 3 and cervical carcinoma by HPV transcript analysis
D. Rijkaart, R.H.M. Verheijen, C.J.L.M. Meijer, P.J.F. Snijders
KWF VU 2006-3570
Lung cancer
49. Evaluation of molecular sputum test diagnostic for lung cancer
A.J. Hubers, D.A.M. Heideman, E.F. Smit, F.B.J.M. Thunnissen
Dept. of Pathology1 and Pulmonology2, VU University Medical Center, Amsterdam
KWF VU 2008-4220
50. Genomic profiling for risk assessment of preneoplastic endobronchial lesions
R. van Boerdonk1, P.J.F. Snijders1, E.F. Smit2, D.A.M. Heideman1
Dept. of 1Pathology and 2Pulmonary Diseases, VU University Medical Center, Amsterdam
KWF VU 2007 3898
Molecular diagnosis and genomics-based staging and personalized therapy of head and neck cancer
51. Determinants of chemotherapy sensitivity
S.R. de Kemp1, C.R. Nagel1, B.J.M. Braakhuis1, A. Brink1, C.R. Leemans1, V.W. van Beusechem2, J.P. de Winter3, R.H.
Brakenhoff1.
1Section Tumor Biology, Dept. of Otolaryngology/Head-Neck Surgery, 2Medical Oncology, VU University Medical Center,
Amsterdam
CCA/V-ICI grant
52. Determinants of radio and EGFR-mediated therapy sensitivity
C.R. Nagel, C.R. Leemans, B.J.M.Braakhuis, R.H. Brakenhoff
Department of Otolaryngology/Head-Neck Surgery, VU University Medical Center
Airforce
53. Improving molecular staging of surgically treated head and neck cancer patients: towards rationalized adjuvant
treatment
A.P. Graveland1, M. de Maaker1, E. Bloemena2, B.J.M. Braakhuis1, C.R. Leemans1, R.H. Brakenhoff1
Depts. 1Otolaryngology/Head-Neck Surgery and 2Pathology, VU University Medical Center, Amsterdam, 3Dept.
Biomolecular Mass Spectrometry, University Utrecht
NKB/KWF 2005-3285
54. Molecular diagnosis of lymph node metastasis in primary head and neck squamous cell carcinoma
S.J. Smeets, C.R. Leemans, B. Ylstra, R.H. Brakenhoff, B.J.M. Braakhuis
Dept. Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam
NKB/KWF 2006-3694
Other projects:
55. EBV-RNA biomarkers in the serum of systemic lupus erythematosus
M. van Eijndhoven, A.E. Voskuyl, I.E.M. Bultink, B.M.E. van Blomberg, J.M. Middeldorp and D.M. Pegtel
56. Enucleation for retinoblastoma - results from 20 years
D.T. Hartong, C.M.F. de Gouyon, M. Bosscha, J.S. Remmers, F. Bak, A.C. Moll
Dept. of Ophthalmology, VU University Medical Center
57. Identification of novel oncogenes/oncomirs located at 13q involved in the progression of colorectal adenoma to
carcinoma
F.L.M. de Groen, R.D.M. Steenbergen, G.A. Meijer, B. Carvalho
CCA/V-ICI
58. Schadelastreductie baarmoederhalskanker door vernieuwend beleid ten aanzien van niet-deelnemers BVOBMHKBHMK
F. van Kemenade1, D.A.M. Heideman1, P.J.F. Snijders1, M. van Baal2, L. Masuger3, R. Bekkers3, W. Melchers4, R. Hol5
Dept. Of Pathology1 and Gynaecology2, VU University Medical Center Amsterdam, Dept. Gynaecology, UMCN3, Mol.
Diagnostics, UMCN4, Delphi Biosciences5
Achmea Gezondheidszorg
59. Tailoring of (immune-)therapy in R-CHOP refractory diffuse large B-cell lymphoma (DLBCL) patients
N. Rekers1, S.A.G.M. Cillessen1, G.J. Ossenkoppele2, J.C. Kluin-Nelemans3, C.J.L.M. Meijer1
Depts. of 1Pathology, 2Hematology, VU University Medical Center, Amsterdam. 3Dept of Hematology, UMCG
KWF 2007-3858
60. Towards improved melanoma treatment: gene identification, in vivo modeling and drug target discovery
D. Peeper, W.J. Mooi
KWF
Program 2
In situ targeting and modulation of dendritic cells for tumor
1. In situ targeting and modulation of dendritic cells for immunotherapy: reversal of suppression
D. Oosterhoff1, J.J. Lindenberg1, R. van de Ven1, H. van Cruijsen1, S.M. Lougheed1, V.W. van Beusechem1, P. van den
Tol3, D.T. Curiel4, W.R. Gerritsen1, A.J.M. van den Eertwegh1, R.J. Scheper2, T.D. de Gruijl1
Depts. of 1Medical Oncology, 2Pathology, and 3Surgical Oncology,VU University Medical Center, Amsterdam and Division
of Human Gene Therapy, UAB, Birmingham, Alabama
108
NWO VIDI 917.56.321
Mycobacterial host-pathogen interaction
2. Contribution of molecular epidemiology and host-pathogen genomics to understand Chlamydia trachomatis and
Bacterial meningitis
S.A. Morré1, EpiGenChlamydia Consortium2
1. Laboratory of Immunogenetics, Department of Pathology, 2. EpiGenChlamyda Consortium,
(www.EpiGenChlamydia.eu): 20 European, African and US Universities and Institutes, 3. EU FP6 funded (Contract N°:
037637)
3. Immune modulation by ESX-5 secreted proteins of mycobacteria
E.M. Weerdenburg, W. Bitter, B.J. Appelmelk
Dept. of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam
V-ICI
4. Immunogenetic, pharmacological and neurodevelopmental aspects of nosocomial sepsis and meningitis in preterm
AGA and SGA infants
F. van den Dungen1 , S.A. Morré2, P. Savelkoul3, M. M. van Weissenbruch1, A.M. van Furth4
1Dept of Neonatology, VUmc, Amsterdam 2Dept. of Immunogenetica, VUmc, Amsterdam; 3Dept of Medical
Microbiology, VUmc, Amsterdam, 4Dept of Pediatric Infectious Diseases, Immunology, and Rheumatology, VUmc,
Amsterdam
5. Immunogenetics and environmental factors in infectious diseases
S Ouburg1, RA Coutinho2, Y Pannekoek3, J Lyons4, Stephan Verweij (PhD student LI), Marieke Sanders (PhD student LI
and Pediatrics), Gijs van Well (PhD student LI and Pediatrics), Vitaly Smelov (PhD student LI)J Land 5, C Bruggeman6, C.
Hoebe6 A. Catsburg8, PH Savelkoul8, CMJEVandenbroucke-Grauls8, M van Agtmael9, M. Van Furth 10JBA Crusius1, AS
Peña1, SA Morré1,
1Lab Immunogen, 2GG&GD Amsterdam, 3AMC Med Microbiol, 4City of Hope Nat Med Center, Dept. Infect
Dis, Duarte, CA, USA, 5AZM, Dept. Gynecol, 6AZM, Dept Med Microbiol, 7Dept. Basic Dental Sci, 8Med
Microbiol Infect Prev, 9Int Med, 10 Pediatrics, VUmc, NL
6. Live mycobacterium bovis BCG bacteria as a platform for the induction of enhanced tumor-antigen-specific
immunity
L.S. Ates, B. Appelmelk, J. Geurtsen, W. Bitter
7. Mycobacterial factors involved in granuloma formation
Esther Stoop, Gunny van den Brink- van Stempvoort, Theo Verboom, Wilbert Bitter, Christina Vanderbroucke-Grauls,
Astrid van der Sar
Smart Mix
8. Mysteries beyond the mycomembrane:biogenesis of the mycobacterial capsule and its role in the host-pathogen
interaction
R. van de Weert, B. Appelmelk, C. Vandenbroucke-Grauls, J.J.G. Geurtsen
NWO/ALW VENI
9. Targeting of proteins to the mycobacterial type VII secretion system ESX-5
M.H. Daleke, W. Bitter
NWO/ALW
10. Unraveling a novel bacterial protein transport system: characterization of mycobacterial secretion system ESX-5
E.N.G. Houben, W. Bitter
Type 1 diabetes and coeliac disease
11. HLA-DQ genotype distribution in Type 1 Diabetes Mellitus patients with concomitant Celiac Disease
S.F. Bakker1, M.E. Tushuizen1, J.B.A. Crusius 2, S Simsek3 , C.J.J. Mulder1, B.M.E. von Blomberg4
1 Department of Gastroenterology and Hepatology, VU University Medical Center, The Netherlands, 2 Laboratory of
Immunogenetics, Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands, 3 Department
of Internal Medicine, Medical Center Alkmaar, The Netherlands, 4 Department of Medical Immunology, VU University
Medical Center, The Netherlands
Coeliac Disease Consortium
12. Type 1 diabetes and celiac disease in adults: Glycemic control and diabetic complications
S.F. Bakker1, M.E. Tushuizen1, B.M.E. von Blomberg2, C.J. Mulder1, S. Simsek3,4
1. Departments of Gastroenterology and Hepatology; 2. Medical Immunology; 3. Internal Medicine, VU University
Medical Center, Amsterdam 4. Department of Internal Medicine, Medical Center Alkmaar, Alkmaar, The Netherlands
Coeliac Disease Consortium
Other projects
13. A prediction model for the development of rheumatoid arthritis in anti-CCP and/or IgM rheumatoid factor positive
arthralgia patients
D. van Schaardenburg1,2, L. v.d. Stadt2, W.H. Bos1, C.L. Verweij1, D. Hamann4, M. Boers5, B.A.C. Dijkmans1,2
1 Jan van Breemen Research Institute / Reade, 2 Dept. of rheumatology, VUMC, Sanquin Research4 and clinical
epidemiology5, VUMC
Reumafonds DAA 0801034
14. Biomarkers in systemic lupus erythematosus
J. Jacobs, L-A. Korswagen, I.E.M. Bultink, B.A.C. Dijkmans, A.E. Voskuyl
Department of Rheumatology, VU University Medical Center
15. Biomarkers in Systemic sclerosis
A.E. Voskuyl
Dept. Of Rheumatology, VU University Medical Center Amsterdam
16. Ceramic microneedle arrays for skin vaccination
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R.J. Scheper, R. Luttge, T.D. de Gruijl
Technical University Tweente seeding grant
COBRA-light study, an open, randomised clinical trial comparing a modified COBRA therapy with the COBRA therapy
in early rheumatoid arthritis
D. den Uyl1, M. ter Wee, M1. Boers1, B.A.C. Dijkmans1, P.J. Kerstens2,3, M.T. Nurmohamed1,2, DJ van
Schaardenburg2, A.E. Voskuyl1, W.F. Lems1,2
¹VU University Medical Center, ²Reade/Jan van Breemen Research Institute, Amsterdam 3West Fries Gasthuis, Hoorn,
The Netherlands
T1-106 of the Dutch Top Institute Pharma
Colorectal cancer surgery: a Trojan horse for liver metastases?
S.K. Grewal, M. van Egmond, R.H.J. Beelen
Dept. Mol. Cell Biology and Immunology, VU University Medical Center
NWO Mozaiek
Complicated celiac disease: pathogenesis, survival and treatment
R.L.J. van Wanrooij, G. Bouma, B.M.E. von Blomberg, C.J.J. Mulder
Dept. Of Gastroenterology, VU University Medical Center
Celiac disease consortium
Cross-talk between MGL and galectin-1 in the regulation of tolerogenic responses in multiple sclerosis
J.M. Ilarregui, G.A.Rabinovich1 and Y. van Kooyk
Depts of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam, 1IBYME;CONICET,
Buenos Aires, Argentina
Dutch Foundation MS Research
Defective IL-1A expression related to MAP3K4 levels in patients with Crohn’s Disease
C.T.M. van der Pouw Kraan1, J.M. Baggen1, A.J.G. Horrevoets1, A. Zwiers1, D. Geerts3, G. Kraal1, G Bouma2
Dept. of Molecular Cell Biology & Immunology, and 2Dept. of Gastroenterology, VUmc, Amsterdam, The Netherlands,
3Department of Human Genetics, Academic Medical Center, University of Amsterdam, The Netherlands
GastroStart (MLDS)
Dendritic cell targeting using nanovesicles to improve anti-cancer therapy
W.W.J. Unger, M. Litjens, M. Verstege, Y. van Kooyk
Depts of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
SENTERNOVEM
Dendritic cell-targeted in vivo tumor vaccination: towards optimised prime-boost protocols
B.N. Hangalapura1, D. Oosterhoff1, R. van de Ven1, J. van Moorselaar2, E. Hooijberg3, V.W. van Beusechem1, W.R.
Gerritsen1, A.J.M. van den Eertwegh1, R.J. Scheper3, Y. van Kooyk4, T.D. de Gruijl1
Depts. of 1Medical Oncology, 2Molecular Cell Biology and Immunology, 3Urology, and 4Pathology, VU University Medical
Center, Amsterdam
KWF-VU / Stichting Avanti/STR 2005-3284
Determination of the contribution of neuronal vs. mesenchymal expression of Raldh2 to lymph node development
S.A. van de Pavert, T. Konijn, R.E. Mebius
NWO 854.10.005
Development of a dermal substitute from human donor skin
C.D. Richters1,2, N.J. Paauw1, R.H.J. Beelen, M.M. Ulrich3
1Dept. of Molecular Cell Biology and Immunology, VU University Medical Center, 2Euro Skin Bank, Beverwijk,
3Vereniging van Samenwerkende Brandwondencentra Nederland, Beverwijk
Dutch Burn Foundation
Development of monoclonal antibodies to multidrug transporter proteins
R.J. Scheper, G. Scheffer
SRP
Diagnosis and prognosis in early arthritis
D. van Schaardenburg1,2, J. Ursum1, K. Britsemmer1, B.A.C. Dijkmans1,2
1. Jan van Breemen Research Institute / Reade, 2. Dept. of rheumatology, VUMC. Funding: Jan van Breemen Research
Institute
Jan van Breemen Research Institute
EBV-MicroRNA containing exosomes: Trojan vesicles carrying hostile message
D.M. Pegtel, D.A. Thorley-Lawson, J.M. Middeldorp
Department of Pathology, VU University Medical Center and Tufts University, Boston, USA
NWO-Veni, ZonMW2008 OZ05PAT110038
Effect evaluation of home treatment program TBM, Cape Town, South Africa
S. van Elsland1; P. Springer2; J. Schoeman2; A.M. van Furth1
Depts. of 1Pediatric Infectiology, Immunology and Rheumatology, VU University Medical Center, Amsterdam, The
Netherlands; 2 Tijgerberg Hospital, Cape Town, SA
Enteroviral infections in children
S. de Crom 1, Dr. Ch. Obihara 1, M. Peeters 2, S.A. Morré 3 , A. M. van Furth 4
1Dept. of Pediatrics, St. Elisabeth Ziekenhuis, Tilburg; 2 Dept. of Medical Microbiology , St. Elisabeth Ziekenhuis,
Tilburg; 3Dept. of Immunogenetica, VUmc, Amsterdam; 4Dept of Pediatric Infectious Diseases, Immunology, and
Rheumatology, VUmc, Amsterdam
European training and research in peritoneal dialyses
E. Ferrantelli1, P.M. ter Wee2, R.H.J. Beelen1
Dept. Of 1Molecular Cell Biology and Immunology and 2Nefrology, VU Universtiy Medical Center, Amsterdam
Marie Curie ITN, FP7
European training and research in peritoneal dialyses
T.L. Foster1, P.M. ter Wee2, R.H.J. Beelen1
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Dept. Of 1Molecular Cell Biology and Immunology and 2Nefrology, VU Universtiy Medical Center, Amsterdam
Marie Curie ITN, FP7
Evaluation of a new anti inflammatory treatments to improve healing of burns
M. Vlig, C.D. Richters12, N.J. Paauw1, E. Middelkoop2, R.W. Kreis2, R.H.J. Beelen1, M. Ulrich2
1Dept. of Molecular Cell Biology and Immunology, VU University Medical Center, 2Vereniging van Samenwerkende
Brandwondencentra Nederland, Beverwijk
Exploration of novel therapeutic options for refactory CD (RCD) and EATL
S. Cillessen, M. von Blomberg, H.J. Bontkes, G. Bouma, C. Mulder
Dept. Of Pathology and Gastroenterology, VU University Medical Center, Amsterdam
Celiac Disease Consortium (CDC/NGI)
Galactofuranose containing glycoconjugates in the cell wall of Aspergillus: aspects of their biosynthesis and
immunological function
B. Tefsen1, J.H. Park2, A. Ram2, I. van Die1
1Department of Molecular Cell Biology & Immunology, VUmc, Amsterdam and 2Institute of Biology, Leiden University,
Leiden
STW
Generation of tolerogenic dendritic cells
P. Papadopoulos, G. Kraal
Eurostar
Genetic profiling in bacterial meningitis
M. Sanders1, S. Ouburg1 , S.A. Morré1 , A.M. van Furth2
1Dept. of Immunogenetica, VUmc, Amsterdam; 2Dept of Pediatric Infectious Diseases, Immunology, and Rheumatology,
VUmc, Amsterdam
Glycan specificity of C-type lectins
K. Bloem, S. van Vliet, N. Koning, Y. van Kooyk
TIPharma
Glycosylation changes in colon carcinoma
E. Saeland, G. Meijer*, Y. van Kooyk
Depts of Molecular Cellular Biology and Immunology and Pathology, VU University Medical Center, Amsterdam
AICR
Glycosylation controls immune homeostasis
J. J. Garcia-Vallejo, H. Kalay, I. Vuist, B. ‘t Hart2, Y. van Kooyk
Depts of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam, 2Immunobiology,
Biomedical Primate Research Center, Rijswijk
NWO-ALW VENI
Glycosylation of the Prostate Antigen PSA as predictive marker for prostate cancer
M. van den Berk, E. Saeland, Y. van Kooyk
Eurostars
Helminth glycoproteins: a new therapeutic option to prevent or ameliorate MS?
L.M. Kuijk, G. Kooij, E.J. Klaver, H.E. de Vries, C.D. Dijkstra, I. van Die
Department of Molecular Cell Biology & Immunology, VUmc, Amsterdam
the Dutch Foundation MS Research
Identification of differentialy glycosylated glycoproteins in human milk and their effects on DCs
N. Koning, E. Saeland, K. Bloem, S.J. van Vliet, Y. van Kooyk
TIPharma
Identification of tumor-derived proteins that modulate macrophage effector functions
R. Braster, M. van Egmond, R.H.J. Beelen
V-ICI
Immune modulating properties of mycobacterial protein secretion system ESX-5
J. Bestebroer, W. Bitter
NovSecTB/EU Framework 7
Immunoglobulin A and neutrophil immunoglobulin A Fc receptor (Fc-alpha-RI) in mucosal infections
M.W.M. van Hout1, L. van der Steen1, J.E. Bakema1,2, M. van Egmond1,2
Depts. of 1Molecular Cell Biology and Immunology, and 2Surgery, VU University Medical Center
NWO
Immunoglobulin A Fc receptor (Fc-alpha-RI)-induced inflammatory diseases
L. van der Steen1, M.W.M. van Hout1, R. Korthouwer1, S. Pouw1, J.E. Bakema1, M. van Egmond1,2
NWO, Agentschap NL, MaagLeverDarmStichting
Importance of glycosylation on the function of dendritic cells
M. Bax, J.J. García Vallejo, Y. van Kooyk
CCA/V-ICI and Bridging grant from the Consortium for Functional Glycomics
Improving early diagnosis of tuberculous meningitis in children
R. Solomons1, J. Schoeman1, A.M. van Furth2
Depts. of 1 Tijgerberg Hospital, Cape Town, SA; 2Pediatric Infectiology, Immunology and Rheumatology, VU University
Medical Center, Amsterdam, The Netherlands
Inflammatory host defense in children with Down syndrome
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C.J.M. Broers1, M.E.Wijerman1,2 ; R.J.B.J. Gemke1 , A.M. van Furth3,4
1Dept. of Pediatrics, VU medical center, 2Dept. of Pediatrics, Diaconesseziekenhuis, Leiden; 3 Dept. of Pediatric
Infectious Diseases-Immunology and Rheumatology, VU University Medical Center, Amsterdam; 4Laboratory of
Experimental Internal Medicine, Academical Medical Center, Amsterdam
iNKT and Vγ9Vδ2-T cell based immunotherapies for solid tumors
F.L. Schneiders1, R.C. de Bruijn1, R.J. Scheper2, H.J. Bontkes2, B.M.E. von Blomberg-van der Flier2, A.J.M. van den
Eertwegh1, G.A.M.S. van Dongen3, R.C. Roovers4, H.M. Verheul1, T.D. de Gruijl,1 H.J. van der Vliet1
Departments of 1Medical Oncology, 2Pathology, and 3Otolaryngology/Head and Neck Surgery, VU University Medical
Center, Amsterdam and 4 Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht
University, Utrecht
ZonMw Clinical Fellowship, KWF Clinical Cancer Research Fellowship
Innate immunity in bacterial meningitis
G.Th.J. van Well1,2 ,D. Visser1, T. van der Poll3, J.J. Roord1, A.M. van Furth1,3
1 Dept. of Pediatric Infectious Diseases-Immunology and Rheumatology, VU University Medical Center, 2 Dept. of
Pediatrics, Maastricht University Medical Center; and 2Laboratory of Experimental Internal Medicine, Academical
Medical Center, Amsterdam
Interactions between siglec-1+ macrophages and dendritic cells: opportunities for anti-melanoma immunotherapy
H.. Veninga, E. Borg, G. Kraal, T.D. de Gruijl, Y. van Kooyk, J.M.M. den Haan
Depts of Molecular Cellular Biology and Immunology and Medical Oncology, VU University Medical Center, Amsterdam
KWF VU2009-4504
Large scale generation and analysis of glycovariants of Derp1 that down modulate the immune response in allergic
asthma
J.J. Garcia Vallejo1, J.M. Ilarregui1, H. Kalay1, I. Heijink2, Y. van Kooyk1
Depts. of 1Molecular Cell Biology & Immunology, VU University Medical Center, and 2Laboratory of Allergology and
Pulmonary Diseases, Department of Pathology and Medical Biology, University Medical Center Groningen, , Groningen
Astma Fonds 3.2.10.040
Liposomes as modulators of macrophage function
N. Paauw, J. Baggen, N. van Rooijen
Lymphoid stroma in control of immunity
A. Baptista and R.E. Mebius
Dept. of Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam
GABBA PhD Program (University of Porto, Portugal)
Macrophages and tumour development
R. Braster1, M. Bögels1,2, R.H.J. Beelen2, M. van Egmond1,2
Depts. of 1Surgery and, 2Molecular Cell Biology and Immunology, VU University Medical Center
Eerste geldstroom via MCBI
Macrophages as effector cells for monoclonal antibody therapy of cancer
M. Bögels1,2, N. Gül2, R.H.J. Beelen2, J. Bonjer1, M. van Egmond1,2
Depts. of 1Surgery and, 2Molecular Cell Biology and Immunology, VU University Medical Center
Heelkunde
Mechanisms of mesenchymal cell differentiation towards stromal lymph node cells
J.J. Koning, G. Goverse, T. Konijn, R.E. Mebius
NWO VICI grant 918.56.612
Metabolomics Study of Tuberculous Meningitis in Children
S. Mason1, R.Solomons2, J.Schoeman2,R.Wevers3, C.Reinecke1, A.M. van Furth4
Depts. of 1Centre for Human Metabolomics, Potchefstroom, SA; 2 Tijgerberg Hospital, Cape Town, SA; 3 Clinical
Chemistry, UMC, Nijmegen; 4Pediatric Infectiology, Immunology and Rheumatology, VU University Medical Center,
MOG glycosylation and the induction of anti-inflammatory responses in Multiple Sclerosis
I. Vuist, J.J. Garcia-Vallejo, B. ‘t Hart1, Y. van Kooyk
Depts of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam, 1Dept. Immunobiology,
BPRC, Rijswijk
Dutch Foundation MS Research
Nerve regeneration in porcine wound models
C.S. van den Brand 1,2, L. van der Steen1, N.J. Paauw1, R.H.J. Beelen1, M.M.W. Ulrich2, E. Middelkoop2, C.D.
Richters,2,3
Brandwondencentra Nederland, Beverwijk, 3Euro Skin Bank, Beverwijk
Preclinical rheumatoid arthritis
M.M.J. Nielen1, W.H. Bos1, L.A van de Stadt1, R.J. van de Stadt1, I.E. van der Horst-Bruinsma2, J. W.R. Twisk3, H.W.
Reesink4, B.A.C. Dijkmans1, 2 D. van Schaardenburg1, 2
1 Jan van Breemen Research Institute / Reade, 2 Dept. of rheumatology, medical statistics3, VUMC, Sanquin Blood
Bank4.
Predicting T-cell lymphoma development in refractory celiac disease patients by profiling of apoptosis pathways in
intestinal T-lymphocytes
J.M.W. van de Water1, L.R. de Baaij1, N.J.Hijmering2, W. Vos2, O.J. Visser3, J.J. Oudejans2,4, B.M.E. von Blomberg2,
M.W.J. Schreurs2, C.J.L.M. Meijer2, C.J.J. Mulder1, S.A.G.M. Cillessen2
Depts. of 1Gastro-enterology and Hepatology,2Clinical Pathology, 3Hematology, VU University Medical Center,
Amsterdam. 4Dept of Pathology, Diakonessenhuis, Utrecht
CCA PV06/18MDL
Prognostic and diagnostic marker analysis in (refractory) celiac disease
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S. Gross, B. M.E. von Blomberg, H.J. Bontkes, I.M.W. van Hoogstraten, K.A.G. Gelderman, G. Bouma, S. Cillessen, C.J.
Mulder, F. Koning
Dept. Of Pathology and Gastroenterology, VU University Medical Center Amsterdam, LU University Medical Center
Leiden
Celiac Disease Consortium (NGI)
Protection against inflammatory bowel diseases by glycan antigens
E.J. Klaver1, L.M. Kuijk1, G. Kraal1, G. Bouma2, I. van Die1
1Department of Molecular Cell Biology & Immunology, VUmc, Amsterdam; 2Dept. Gastroenterology, VU University
the Broad Medical Research Program of the Broad Foundation (USA)
Regulation of expression of retinaldehyde dehydrogenase enzymes in musocal dendritic cells
R. Molenaar, G. Goverse, R.E. Mebius
NWO VICI 918.56.612
Regulation of immune reactivity in inflammatory bowel disease
A. Zwiers, M. Bajek, G. Bouma*, G. Kraal
Depts of Molecular Cellular Biology and Immunology, and Gastroenterology, VU University Medical Center, Amsterdam
Retinoic acid mediates macrophage differentiation towards a separate lineage
G. Goverse, T. Konijn, R.E. Mebius
NWO
Role of epithelial barrier disruption in Inflammatory Bowel Disease
I. Hiemstra, G. Bouma, J.M.M. den Haan, G. Kraal
Depts of Molecular Cellular Biology and Immunology and Gastroenterology, VU University Medical Center, Amsterdam
Role of fibroblasts and subpopulations macrophages and other cell types in wound healing
J.E. Glim, M. van Walraven, B. Mahdavian, W. van der Veer, L. Butzelaar, N.J. Paauw1, M. Gouverneur, F.J. Niessen, M.
van Egmond, M.M. Ulrich, R.H.J. Beelen1
Brandwondencentra Nederland, Beverwijk
Dutch Burn Foundation. MOVE, NIRM and NWO
Screening of new carbohydrate components that prevent pathogen binding to DC-SIGN
M. Perdicchio, M. Ambrosini, W. Unger, Y. van Kooyk
Carmusys FP7 EU Marie Curie Network
Signaling pathways in homeostasis and function of dendritic cells
M. Beijer, G. Kraal and J.M.M. den Haan
Dept of Molecular Cellular Biology and Immunology, VU University Medical Center, Amsterdam
NWO-ALW Meervoud to J.M.M. den Haan
Skin and mucosal allergies to dental metals
D Rachmawati, J. Muris1) von Blomberg BME, R.J. Scheper, .M.W. van Hoogstraten
Dept. Of Pathology, VU University Medical Center, Amsterdam; 1) Dept dental materials Science, ACTA, Amsterdam,
Dept. Nat. Educ. Indon., Directorat General of Higher Degree education
Dept. Nat. Educ. Indon., Directorat General of Higher Degree education
Surgery induced development of liver metastases
N. Gül1, S. Grewal1,2, R.H.J. Beelen1, M. van Egmond1,2
Eerste geldstroom via MCBI
Surgery induced development of liver metastases
S. Grewal1,2, N. Gül1, R.H.J. Beelen1, J. Bonjer2, M. van Egmond1,2
NWO, Mozaiek
Targeting dendritic cells with glycosylated liposomes in defense against prostate cancer
A.J. van Beelen1, B. Hangalapura2, T.D. de Gruijl2, Y. van Kooyk1
Depts. of 1Molecular Cell Biology and Immunology, VU University Medical Center, and 2Medical Oncology, VU University
Medical Center
CCA/V-ICI
Targeting mMGL-1 and mMGL-2 on murine DCs to modulate immune responses
I. Ouwehand, E. Saeland, Y. van Kooyk
VUmc Research Institute: CCA/V-ICI
The design of glyco-peptide dendrimers to improve DC targeted antigen presentation
M. Ambrosini, M. Perdicchio, H. Kalay, J.J. Garcia Vallejo, Y. van Kooyk
Carmusys FP7 EU Marie Curie Network
The development of immuno-competent human skin and oral mucosa equivalents and their use in determining
factors involved in T cell skewing and imprinting
I. Kosten1, S.W. Spiekstra1, B.M.E. von Blomberg2, T. Rustemeyer1, R.J. Scheper2, T.J. De Gruijl2, S. Gibbs1
Departments of 1Dermatology and 2Pathology, VU University Medical Center
The effect of HIV infection and AZT-3TC-NVP/EVF therapy on vascular and metabolic changes in patienst with HIV
T.Msoka1, Y.Smulders2, M.van Agtmael2, J.Bartlett3, A.M. van Furth4
Depts. of 1Centre for Human Metabolomics, Potchefstroom, SA; 2 VUmc, Amsterdam, The Netherlands; 3 John
Hopkins, Baltimore, USA; 4Pediatric Infectiology, Immunology and Rheumatology, VU University Medical Center,
The generation of tolerance inducing vaccines
J.B. Vos, K. Vrijland, G. Kraal
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Eurostar
The host immune response to tuberculous meningitis
D. Visser 1 , R.Solomons2, J.Schoeman2, A.M. van Furth1
Netherlands; 2 Tijgerberg Hospital, Cape Town, SA
The influence of vitamin A metabolism on immune cell differentiation in the gut
J. Bar-Ephraim1, G. Bouma2, R. Mebius1
Dept. Of 1Molecular Cell Biology and Immunology and 2Gastroenterology, VU University Medical Center, Amsterdam
1e geldstroom
The potential of Fc-alpha-RI as trigger molecule for antibody therapy of cancer
J.E.Bakema1, S. Ganzevles, C. Tuk1, M. van Egmond1,2
NWO, CCA/V-ICI
The rich focus in tuberculous meningitis: form pathology to mathematics
M. van der Kuip1, M. El-Kebir1, D. Kirschner2, A.M. van Furth1
Netherlands and 2Microbiology and Immunology, The University of Michigan Medical School, Ann Arbor, MI, USA
European Society for Paediatric Infectious Diseases / Wyeth (to MvdK) and the National Institutes of Health HL092853-01
(to DK)
The role of galectins in interaction of tumour cells with the immune system
A. Belo, B. Tefsen, I. van Die
Department of Molecular Cell Biology & Immunology, VUmc, Amsterdam
the Portuguese FCT to A. Belo and STW
The role of retinoic acid in regulation of gene expression during lymph node formation
D. Schooneman, R.E. Mebius, S.A. van de Pavert
NWO ZonMW Horizon
Towards adjuvant immunotherapy for squamous cell carcinoma
AW Turksma, JJ Ruizendaal, H van den Heuvel, CJLM Meijer, CR Leemans and E Hooijberg
Dept. of Pathology, VU University Medical Center Amsterdam
KWF VU2007-3814
Vaccine delivery: alternatives for conventional multiple injection vaccines
T. van Es, A.J. van Beelen, W.W.J. Unger, S.C.M. Bruijns and Y. van Kooyk
TIPharma
Variations in T cell glycosylation direct the interaction with dendritic cells
S.J. van Vliet and Y. van Kooyk
Mizutani Foundation for Glycosciences
Program 3
Alternative proteomics strategies for discovery of biofluid and imaging biomarkers and drugable targets
1. Cell surface proteomics of osteosarcoma identifies EPHA2 as receptor for targeted drug delivery
J. PosthumaDeBoer1, S.R. Piersma2, T.V. Pham2, J.C. Knol2, V.W. van Beusechem3, G.J.L. Kaspers4, B.J. van
Royen1,5, C.R. Jiménez2 §, M.N. Helder1,5 §
1) Department of Orthopaedic Surgery, 2) Oncoproteomics Laboratory, 3) Department of Medical Oncology, 4) Paediatric
Oncology/Haematology, VU University Medical Center, Amsterdam
CCA
2. Platelet proteomics for cancer biomarker discovery
M. Walraven1, S.R. Piersma2, H.J. Broxterman1, H.M.W. Verheul1*, C.R. Jiménez2*
1Angiogenesis Laboratory and 2OncoProteomics Laboratory, Dept. Medical Oncology, VU University Medical Center,
Amsterdam
VUmc CCA, Aegon
3. Proteomics of exosomes secreted by cancer cell lines and primary cells
M. Lavaei1, R.J.A. Fijneman2, D.M. Fluitsma3, J.C. Knol1, S.R. Piersma1, T.V. Pham1, R. Steenbergen2, G.A. Meijer2,
M. Pegtel2, H.M.W. Verheul1, C.R. Jimenez1
1Dept. Pathology, 2Dept. Medical Oncology, 3Dept. Mol. Cell. Biology and Immunology, VU University Medical Center
CCA
Brain proteomics
4. Proteomics of meningiomas in correlation with growth rate
S. Peerdeman1, TMB. Schaaij-Visser2, R. Ariana1, JC. Knol2, S. Piersma2, CR. Jimenez2
1Dept. Neurosurgery, 2OncoProteomics Laboratory, Dept. Medical Oncology, VUmc-Cancer Center Amsterdam, VU
University Medical Center, Amsterdam, The Netherlands
CCA
Breast cancer proteomics
5. Exploring differences in short-term response to cisplatin in sensitive and non-sensitive mouse mammary tumors
M. Warmoes1*, J. Jaspers2*, S. Rottenberg2, S. Piersma1, C.R. Jimenez1*, J. Jonkers2*
1OncoProteomics Laboratory, Dept. Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands,
2Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
CenE/Van Lanschot and the VUmc Cancer Center Amsterdam
6. Proteomics of murine BRCA1 deficient breast tumors identifies DNA repair proteins with prognostic value in human
breast cancer
114
M.O. Warmoes¹, J. Jaspers2, T.V. Pham1, S. Piersma1, M.P.G. Massink3, H. Meijers-Heijboer3, Q. Waisfisz3, S.
Rottenberg2, E. Boven1, J. Jonkers2, C.R. Jimenez1
1Oncoproteomics Laboratory, Dept. of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
2Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. 3Dept. Clinical
Genetics, VU University Medical Center, Amsterdam
CenE/Van Lanschot and the VUmc CCA
Chronic inflammatory diseases
7. Immunogenetics and disease profiling of Chronic inflammatory, autoimmune and Infectious diseases
J.B.A. Crusius1 (PI, LI), I.E. van der Horst-Bruinsma2 (PI Reuma), Stephan Verweij (PhD student LI), Marieke Sanders
(PhD student LI and Pediatrics), Gijs van Well (PhD student LI and Pediatrics), Vitaly Smelov (PhD student LI), N. de
Vries3, G. J. Wolbink4,5, A.A. van Bodegraven6 (PI MDL), B.M.J. Uitdehaag7, C.H. Polman8 (PI, Neuro), M. Van Furth9
(PI, Pediatrics), C. Verweij(2,10), A.S. Peña1, S.A. Morré1
1Laboratory of Immunogenetics, Dept Medical Microbiology and Infection Control), VU University Medical Center, 2Dept
Rheumatology VU University Medical Center, 3Dept Rheumatology, Academic Medical Center, 4Reade/Jan van Breemen
Institute, 5Sanquin Research, 6Dept Gastroenterology VU University Medical Center, 7Dept Epidemiology & Biostatistics,
8Dept Neurology, VU University Medical Center, Amsterdam. 9Pediatrics, VUmc. 10Dept Pathology, VUmc.
Funding: amongst others NGI (2011), and 2x NIH (2011). EU FPs: IBD-CHIP and EpiGenChlamydia ended in 2011
Colorectal cancer proteomics
8. Enrichment of tumorigenic stem-like cells in biopsy spheroids from colorectal cancer
U. Rajcevic1, J.C. Knol2, S. Piersma2, S. Bougnaud1, T.V. Pham2, E. Sundlisaeter3, P. Enger3, R. Bjerkvig1,3, S.P.
Niclou1, C.R. Jimenez2
1NorLux Neuro-Oncology, CRP-Santé, Luxembourg, 2OncoProteomics Laboratory, Dept. Medical Oncology, VU University
Medical Center, Amsterdam; 3Department of Biomedicine, University of Bergen, Bergen, Norway
CCA
9. Identification of new Biomarkers for Colon Cancer using integration of Genomics and Cell Surface Proteomics
M. de Wit1, C.R. Jimenez2, B. Carvalho1, J.A.M. Belien1, P.M. Delis-van Diemen1, S. Mongera1, S.R. Piersma2, G.A.
Meijer1, R.J.A. Fijneman1
1Dept. Pathology (Tumor Profiling Unit), 2Dept. Medical Oncology (OncoProteomics Laboratory), VU University Medical
Center
Phillips research and VUmc CCA
10. Label-free LC-MS/MS profiling of chromatin-associated proteins in colorectal adenoma and carcinoma tissues
J. Albrethsen1, J.C. Knol1, T.V. Pham1, S.R. Piersma1, S. Mongera?2, B. Carvalho2, M. de Wit2, R.J.A. Fijneman2, G.A.
Meijer2, C.R. Jimenez1*
1OncoProteomics Laboratory, Dept. Medical Oncology, 2Dept. Pathology, VU University Medical Center, Amsterdam. The
Netherlands
CCA
11. Protein biomarker discovery in stool for the early detection of colorectal cancer
L.J.W. Bosch1, M. de Wit1,2, G. Oudgenoeg2, S. Mongera1, S. Piersma2, T. Pham2, J.S. Terhaar Sive Droste3, C.J.J.
Mulder3, B. Carvalho1, R.J.A. Fijneman1, C.R. Jimenez2, G.A. Meijer1
1Dept. Pathology (Tumor Profiling Unit), 2Dept. Medical Oncology (OncoProteomics Laboratory), 3Dept.
Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands
VUmc CCA and CTMM-DeCoDe
12. Proteome profiling of mouse colon tumor proximal fluids reveals candidate biomarkers for colorectal cancer
screening
R.J.A. Fijneman1,2, M. de Wit1, M. Pourghiasian1,2, S. Piersma2, M. Warmoes2, P.M. van Diemen1, C. Piso1, E.C.
Robanus-Maandag3, R. Smits4, R. Fodde4, V.W.M. van Hinsbergh2,5, G.A. Meijer1, C.R. Jimenez2
1Dept. of Pathology, 2Dept. of Medical Oncology, 5Dept of Physiology, VU University Medical Center, 3Dept. of Human
Genetics, Leiden University Medical Center, Leiden, The Netherlands 4 Dept. of Pathology, Josephine Nefkens Institute,
Erasmus MC, Rotterdam, the Netherlands
Aegon International Scholarship in Oncology, and by the VUmc-Cancer Center Amsterdam.
13. Proteomics of colon cancer stem cells (CSC) and their isogenic differentiated progeny
B. Emmink1, W. van Houdt1, T.V. Pham2, S. Piersma2, I. Borel Rinkes1, C. Jimenez2^, O. Kranenburg1^
1Dept. Surgical Oncology, University Medical Center Utrecht and 2OncoProteomics Laboratory, Dept. Medical Oncology,
14. Proximal Fluid Proteome Profiling of Human Colorectal Cancer Tissue Reveals Candidate Biomarkers for CRC
screening
R.J.A. Fijneman1, H. Kant2, M. de Wit1, S.R. Piersma2, T.V. Pham2, M. O. Warmoes2, S. Mongera1, H.M.W. Verheul2,
G.A. Meijer1, C.R. Jimenez2
Dept. of 1Pathology, 2OncoProteomics Laboratory, Dept. Medical Oncology, VU University Medical Center, Amsterdam,
The Netherlands
Aegon International Scholarship in Oncology, and by the VUmc-Cancer Center Amsterdam.
15. Targeted mass spectrometry-based candidate biomarker validation in biological matrices
G. Oudgenoeg1, L. Bosch2, M. de Wit1, R.J.A. Fijneman2, G.A. Meijer2 , C.R. Jimenez1
*OncoProteomics Laboratory, Dept. Medical Oncology, and **Tumor Profiling Unit , Dept. Pathology, VUmc Cancer
Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
CTMM DeCoDe
High-throughput body fluid peptide profiling by MALDI mass spectrometry for patient stratification by pattern diagnosis
16. Mass spectrometric serum peptide profiling for drug response prediction: signature validation
T.V. Pham1, J.C. Knol1, J.S.W. Lind2, H.M.W. Verheul1, E.F. Smit2, C.R. Jimenez1
1Department of Medical Oncology, VU University Medical Center, 2Department of Pulmonary Diseases, VU University
Medical Center
VUmc CCA
17. Serum peptide profiling in non-small cell lung cancer patients treated with sorafenib and erlotinib
T.V. Pham1, J.S.W. Lind2, J.C. Knol1, A.-M.C. Dingemans3, H.J.M. Groen4, P.E. Postmus1, C.R. Jimenez1*, E.F. Smit 2*
115
Departments of 1Medical Oncology and 2Pulmonary Diseases VU University Medical Center Amsterdam, 3Maastricht
University Medical Center and 4University Medical Center Groningen
VUmc CCA
Imaging: Brain tumours
18. Assessment of blood-brain barrier function in pharmacoresistant patients with tumor-related epilepsy
F. Froklage1, R.A. Voskuyl7, J.J. Heimans1, N.H.M. Hendrikse3,4, J.C. Baayen2, R.M.C. Debets6, D. Velis5, A.A.
Lammertsma3, J.C. Reijneveld1,5,
Departments of 1Neurology, 2Neurosurgery and 3Nuclear Medicine and PET-research, 4. Clinical Pharmacology and
Pharmacy, VU University Medical Center, Department of 5Neurology, Academic Medical Center, Amsterdam,
Departments of 5Neurology and 6Clinical Neurophysiology, Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede,
and 7Department of Pharmacology, Leiden/Amsterdam Center for Human Drug Research (L/A CHDR), Leiden
Europese Unie Framework Program 7 (FP7 EURIPIDES project)
Imaging: Colorectal tumours
19. Molecular imaging for personalized therapy in metastatic colorectal cancer
J. Goos1, R. Fijneman1, A.A. Geldof2, O.S. Hoekstra2, L. Perk3, G.A. Meijer1
Dept. Of 1Pathology, 2Nuclear Medicine & PET research, VU University Medical Center, Amsterdam, 3 BV Cyclotron
CTMM
20. Molecular imaging of early stage disease
M. de Wit, R. Fijneman, M. van der Wiel, R. Lamerichs, C. Jimenez, J. Stoker, G.A. Meijer
CTMM
Imaging: Generic
21. Antibody derivatives as molecular agents for neoplastic targeting
D. Vugts1, G.W.M. Visser2, G.A.M.S. van Dongen1,2
Dept. of 1Otolaryngology/Head-Neck Surgery, and 2Nuclear Medicine & PET research, VU University Medical Center,
Amsterdam
Roche
22. Development of dual-specific nanobodies for cancer diagnosis and treatment
M. Vosjan1, M. Stigter-van Walsum1, R. Roovers3, P.M P. van Bergen en Henegouwen3, G.A.M.S. van Dongen1,2
Dept. of 1Otolaryngology/Head-Neck Surgery VU University Medical Center, 2Nuclear Medicine & PET Research VU
University Medical Center, 3Dept. Cellular Architecture & Dynamics, Utrecht University
NWO/STW 10074
23. Effect of anti-CD44 (RO5429083) and the bispecific antibody (A2V) treatment on tumor uptake of 11C-docetaxel in
pre-clinical xenograft studies
C.F.M. Molthoff1, I. de Greeuw1, M.Verlaan1, R. Bergstra1, A.A. Lammertsma1
Dept. of 1Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam
Roche Diagnostics, Germany
24. FLT- and FDG-PET imaging to support dose-finding for the CD-44 (RO5429083) program in preclinical xenograft
studies
C.F.M. Molthoff1, I. de Greeuw1, M.Verlaan1, R. Bergstra1, A.A. Lammertsma1
Dept. of 1Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam
Roche Diagnostics, Germany
25. In vivo imaging of Epstein Barr Virus Activation by cytolytic antiviral therapy in nasopharyngeal carcinoma cell lines
and xenograft models
A.E. Greijer1, Z. Novalic1, M. Verlaan2, J. Eersels2, C.F.M. Molthoff2, J.M. Middeldorp1
Depts. of 1Pathology and 2Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam
ZonMW2010, KWF VU 2010-4809
26. Quantitative imaging in cancer: connecting cellular processes with therapy: Data and Image Analysis (WP4)
L.L. Hoyng, M. Yaqub, F. van Velden, R. Boellaard
Dept. Of Nuclear Medicine & PET research, Vu University Medical Center, Amsterdam
IMI EU project QuicConcept (EORTC, CR-UK, EFPIA)
27. Technical validation of DW-MRI, FLT and ICMT-PET as read-outs of proliferation and apoptosis in drug development
V. Frings, L. Hoyng, JPA Kuijer, IC Pieters, R Boellaard, EF Smit, W Menke, OS Hoekstra
Dept of Nucl Med & PET research, Radiology, FMT, Pulmonary Oncology, Medical Oncology, VU University Medical
Center, Amsterdam
IMI EU project QuicConcept (EORTC, CR-UK, EFPIA)
28. The development of radiolabeled tyrosine kinase inhibitors for PET imaging
P. Slobbe, G.A.M.S. van Dongen
Dept. of Otolaryngology/Head-Neck Surgery VU University Medical Center, Amsterdam
CCA/V-ICI
29. The development of radiolabeled tyrosine kinase inhibitors for PET imaging: a predictive tool for cancer therapy
A.J. Poot, G.A.M.S. van Dongen, A.D. Windhorst, N.H. Hendrikse, O.S. Hoekstra, H.M.W. Verheul, E.F. Smit
Depts of Nuclear Med & PET research, Medical Oncology, Pulmonology, Otolaryngology/Head-Neck Surgery
CCA
30. The selective targeting of angiogenesis and of tumour stroma
R. Cohen1, R. de Bree1, M. Stigter-van Walsum1, G.W.M. Visser2, D. Neri3, C.R. Leemans1, G.A.M.S. van Dongen1,2
Dept. 1Otolaryngology/Head-Neck Surgery, 2Nuclear Medicine & PET Research VU University Medical Center, 3Swiss
Federal Institute of Technology,Zürich, Switzerland
European commision FP6-LSHC-CT-2003-503233
31. Towards personalized treatment planning of chemotherapy: 11C-docetaxel PET studies in lung cancer patients
A.A.M. van der Veldt, M. Lubberink, N.H. Hendrikse, E.F. Smit, A.A. Lammertsma
Depts Nucl Med & PET research, VU University Medical Center, Amsterdam
CCA
32. Towards targeted therapy: quantitative imaging with PET and long lived isotopes
N. Makris, R. Boellaard, M.C. Huisman, A.A. Lammertsma
116
Department of Nuclear Medicine & PET research, VU University Medical Center, Amsterdam
Philips Healthcare
33. Validation of imaging response criteria in oncology: focus on FDG PET-CT
S.N.F. Rizvi, A. Vincent, R. Boellaard, H. van Tinteren, O.S. Hoekstra
Dept Nucl Med & PET research, VU University Medical Center, and Dept of Biostatistics, Neth Cancer Institute,
Amsterdam
2 NIBIB projects funded by Rad Soc North America (RSNA)
Imaging: Haematological malignancies
34. Positron Emission Tomography (PET) for detection of histologic transformation of indolent non-Hodgkin’s
Lymphoma
M.J. Wondergem1, J.M. Zijlstra1, S.A.G.M. Cillessen2, J.J. Oudejans2, O.S. Hoekstra3, M.E.D. Chamuleau1, S.
Zweegman1, P.C. Huijgens1
Department of Hematology1, Pathology2, Nuclear medicine & PET research3 VU University Medical Center
de Vilder Stichting
Imaging: Head & Neck tumours
35. Detection of residual neck disease after chemoradiation by PET-CT
S. Faraj-Hakim, O.S. Hoekstra, R. de Bree
36. Evaluation and prediction of response
L. van der Putten1, O.S. Hoekstra3, C.R. Leemans1, R. de Bree1
Depts. of 1Otolaryngology/Head-Neck Surgery, 2Nuclear Medicine / PET Research, 3Oral and Maxillofacial Surgery,
4Radiology and 5Pathology, VU University Medical Center
ZonMw and CCA 945-04-311, 80-82305-98-08106
37. FDG-PET for avoidance of futile direct laryngoscopies under general anasthesia with taking op biopsies in patiens
with suspicion on recurrent laryngeal carcinoma after radiotherapy
L. van der Putten1, I. van der Waal2, O.S. Hoekstra3, E. Bloemena5, C.R. Leemans1, R. de Bree1
ZonMw and CCA 945-04-311, 80-82305-98-08106
38. Improvement of the sentinel node procedure in head and neck cancer by PET-CT lymfoscintigraphy, optical
techniques and minimal invasive surgery. Molecular targeting of intracellular proteins in cancer
Heuveling D, G.A.M.S. van Dongen, C.R. Leemans, R. de Bree
39. Screening on distant metastases using whole-body MRI
I. Pieters1, J.A. Castelijns1, R. de Bree2
Dept. of 1Radiology and 2Otolaryngology/Head-Neck Surgery VU University Medical Center, Amsterdam
Imaging: Head & Neck tumours
40. Ultrasound guided fine needle aspiration cytology and sentinel node biopsy in the detection of occult lymph node
metastases of early oral and oropharyngeal cancer
G.B. Flach, J. Castelijns, O.S. Hoekstra, E. Bloemena, G.A.M.S. van Dongen, C.R. Leemans, R. de Bree
ZonMw 80-82305-98-08106
Imaging: Lung Cancer
41. PET tracers for (chemo)radiation of lung and head and neck cancer
A. Poot1, N.H. Hendrikse2,3, G.A.M.S. van Dongen1,2
Depts. of 1Otolaryngology/Head-Neck Surgery, 2Nuclear Medicine & PET Research and 3Clinical Pharmacology and
Pharmacy, VU University Medical Center,
CTMM Air Force
42. Quantification and tumor delineation with PET
P Cheebsumon, FH van Velden, M Yaqub, OS Hoekstra, EF Smit, R Boellaard
Depts of Nucl Med & PET research & Pulmonology, VU University Medical Center
CTMM AirForce
Imaging: Paediatric tumours
43. Development of pediatric brain tumor. Diffuse intrinxic pontine glioma (DIPG) models for improvement of imaging
and therapy
P. Wesseling1, T. Würdinger2, E. Hulleman3, G.J. Kaspers3
Depts of 1pathology, 2Neurooncology Research Group, 3Pediatric Oncology/ Hematology, VU University Medical Center,
4VU University RNC, 5Massachusetts General Hospital and Harvard Medical School, Boston, MA
Stichting Kika
44. Exploration of target-expression using 89Zirconium labelled antibodies in a diffuse intrinsic pontine glioma mouse
model
M.H.A. Jansen1, T. Lagerweij2, C.F.M. Molthoff3, D. Noske2
Dept. Of 1Child Oncology, 2Neurosurgery and 3 Nuclear Medicine&PET Research, VU University Medical Center,
Amsterdam
Imaging: Prostate cancer
45. Towards personalized therapy in prostate cancer: the role of imaging (preclinical and clinical studies)
D. Oprea-Lager, A.J.M. van den Eertwegh, R.J.A. van Moorselaar, W.R. Gerritsen, A.A. Geldof, R. Boellaard, O.S.
Hoekstra
Depts Nucl Med & PET research, Medical Oncology, Urology, VU University Medical Center, Amsterdam
Imaging: Retinoblastoma
46. Clinical and experimental high resolution ocular MR imaging: towards improved detection of retinoblastoma tumor
extent
P. de Graaf1, P. van der Valk2, A.C. Moll3, S.M. Imhof7, A.Y.N. Schouten-van Meeteren4, D.L. Knol5, P.W.J. Pouwels6,
J.A. Castelijns1
117
Departments of Radiology1, Pathology2, Ophthalmology 3 and Epidemiology and Biostatistics5, Physics and Medical
Technology6, VU University Medical Center, Department of Pediatric Oncology4, Emma Children’s Hospital, Academic
Medical Center, Amsterdam, and Department of Ophthalmology, University Medical Center Utrecht
Grant ZonMw-AGIKO 2006, ODAS Foundation, National Foundation for the Blind and Visually Impaired, Blindenhulp
Foundation, Dutch Eye Fund (Grant 2004-23)
47. CT- and MR-imaging characteristics of cranio-facial second primary tumors in retinoblastoma patients previously
treated by radiation therapy
F. Rodjan1, P. de Graaf1, H.J. Brisse2, J.I.L.M.Verbeke1, E. Sanchez1, P. Maeder3, S. Göricke4, P. Galluzzi5, A.C.
Moll6, D.L. Knol7, J.A. Castelijns1
1Dept. of Radiology, VU University Medical Center, Amsterdam, The Netherlands, 2 Dept. of Radiology, Institut Curie,
Paris, France, 3 Dept. of Radiology, University Hospital, Lausanne, Switzerland, 4Dept. of Diagnostic and Interventional
Radiology and Neuroradiology, University Hospital Essen, Germany, 5 Dept. of Radiology, Azienda Ospedaliera e
Universitaria Santa Maria alle Scotte Siena, Italy, 6Dept. of Ophtalmology, VU University Medical Center, Amsterdam,
The Netherlands, 7 Dept. of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
48. Retinoblastoma: Value of Dynamic Contrast-enhanced MR Imaging and Correlation with Tumor Angiogenesis
F. Rodjan1, P. de Graaf1, P. van der Valk2, A.C. Moll3, J.P.A. Kuijer4, D.L. Knol5, J.A. Castelijns1, P.J.W.Pouwels4
Departments of Radiology1, Pathology2, Ophthalmology 3, Physics & Medical Technology4 and Epidemiology and
Biostatistics5, VU University Medical Center, Amsterdam, The Netherlands
ZonMw-AGIKO 2006, ODAS Foundation, National Foundation for the Blind and Visually Impaired, Blindenhulp Foundation,
Dutch Eye Fund (Grant 2004-23)
49. Trilateral retinoblastoma: neuroimaging characteristics and value of routine brain screening on admission
F. Rodjan1, P. de Graaf1, S. Göricke2, H.J. Brisse3, P. Maeder4, P. Galluzzi5, A. Moll6, I. Aerts7, C. Alapetite9, L.
Desjardins9, M. Beck Popovic10, M. Diezi11, F.L. Munier11, T. Hadjistilianou12, D.L. Knol 13, J.A. Castelijns1
1Dept. of Radiology, VU University Medical Center, Amsterdam, The Netherlands, 2Dept. of Diagnostic and
Interventional Radiology and Neuroradiology, University Hospital Essen, Germany, 3Dept. of Radiology, Institut Curie,
Paris, France, 4Dept. of Radiology, University Hospital, Lausanne, Switzerland, 5 Dept. of Radiology, Azienda
Ospedaliera e Universitaria Santa Maria alle Scotte Siena, Italy, 6Dept. of Ophtalmology, VU University Medical Center,
Amsterdam, The Netherlands, 7Dept. of Pediatric oncology, Institut Curie, Paris, France, 8Dept. of Radiotherapy,
Institut Curie, Paris, France, 9Dept. of Ophtalmology Surgery, Institut Curie, Paris, France, 10Dept. of Pediatric
Hematology-Oncology Unit, University Hospital, Lausanne, Switzerland, 11Jules Gonin Eye Hospital, University of
Lausanne, Vaud, 12Dept. of Ophtalmology Azienda Ospedaliera e Universitaria Santa Maria alle Scotte Siena, Italy,
13Dept. of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
Imaging: Rheumatoid diseases
50. [11C]-(R)-PK11195 PET imaging of subclinical synovitis in rheumatoid arthritis patients in clinical remission
Y.Y.J. Gent, A.E. Voskuyl1, R.W. Kloet 2, E.F.I. Comans2, O.S. Hoekstra2, A.A. Lammertsma2, B.A.C. Dijkmans1, C.J.
van der Lakenl1
Depts of 1Rheumatology, 2Nuclear Medicine & PET Research, VU University Medical Center
51. [11C]-(R)-PK11195 PET imaging of subclinical synovitis in the pre-clinical phase of rheumatoid arthritis
Y.Y.J. Gent1, A.E. Voskuyl1, R.W. Kloet 2, E.F.I. Comans2, D. van Schaardenburg3, O.S. Hoekstra2, A.A. Lammertsma2,
B.A.C. Dijkmans1, C. J. Van der Laken1
Depts of 1Rheumatology, 2Nuclear Medicine & PET Research, VU University Medical Center,3Jan van Breemen Institute,
Amsterdam
52. Development of imaging markers, using PET(-CT), for early detection of RA and therapy monitoring
Y.Y.J. Gent1, K. Weijers1, I. de Greeuw2, M. Verlaan2, A.D. Windhorst2, C. J. Van der Laken1, A.A. Lammertsma2, O.S.
Hoekstra2, B.A.C. Dijkmans1, C.F.M. Molthoff2, C.J. van der Laken1
Depts of 1Rheumatology, 2Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam
53. Imaging of ankylosing spondylitis by PET-CT
S.T. Bruijnen1 ,M.A.C. van der Weijden1, N.Hoetjes2, A.E. Voskuyl1, O.S. Hoekstra2, R. Boellaard2, J.P. Klein3, B.A.C.
Dijkmans1, I. E. van der Horst-Bruinsma1, C. J. Van der Laken1
Depts of 1Rheumatology, 2Nuclear Medicine & PET Research, 3Radiology, VU University Medical Center, Amsterdam
Imaging: Thyroid cancer
54. Recurrent differentiated thyroid cancer: towards personalized treatment based on evaluation of tumor
characteristics with PET (THYROPET)
J. Kist, MPM Stokkel, MC Huisman, OS Hoekstra, B de Keizer, W. Vogel
Depts of Nuclear Medicine AvL/NKI, UMCU, VUmc
KWF
Improvement of the diagnosis of head and neck squamous cell carcinoma (HNSCC)
55. Diagnosis and treatment of recurrent laryngeal carcinoma
L. van der Putten1, O.S. Hoekstra3, J.A. Castelijns3, E. Bloemena4, C.R. Leemans1, R. de Bree1
56. Molecular targeting of intracellular proteins in cancer
D. Heuveling, G.A.M.S. van Dongen, C.R. Leemans, R. de Bree
Lung cancer proteomics
57. Exploration of sputum to develop protein-based assays for early detection, prognosis and drug response of lung
cancer
T.B.M. Schaaij-Visser1, B. Colak1, J. Hubers2, E.F. Smit3, (Erik) F.B.J.M. Thunnissen2, C.R. Jimenez1
1 OncoProteomics Laboratory, Department of Medical Oncology; 2 Department of Pathology, 3Dept. Pulmonology, VU
University Medical Center, Amsterdam, The Netherlands
VUmc CCA
58. Novel candidate biomarkers for cisplatin response prediction and monitoring in NSCLC
T.B.M. Schaaij-Visser1, N. Proost2, R. Nagel3, S.R. Piersma1, T.V. Pham1, R.H. Brakenhoff3, A. Berns2, C.R. Jimenez1
118
1OncoProteomics Laboratory, Department of Medical Oncology, 2Division of Molecular Genetics and Centre for
Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands; 3Department of
Otolaryngology/Head and Neck surgery, VU University Medical Center, Amsterdam
CTMM Airforce
Mining high dimensional proteomics data
59. Network-based data analysis for marker prioritization for targeted mass spectrometry validation
T.V. Pham1, L.G. Leon1, M.O. Warmoes1, S.R. Piersma1, C.R. Jimenez1
1OncoProteomics Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam
VUmc CCA
60. Strategies for analyzing spectral count data in label-free tandem mass spectrometry-based proteomics
T.V. Pham, M. Warmoes, S.R. Piersma, C.R. Jimenez
OncoProteomics Laboratory, Department Medical Oncology, VUmc-Cancer Center Amsterdam, VU University Medical
Center
VUmc CCA
Signaling pathway proteomics for insight into cancer signaling, identification of drug targets and biomarkers for patient
stratification
61. Development of kinobeads for comprehensive capture of the kinome prior to analysis by proteomics
S.R. Piersma1, I. de Reus1, J. Weterings2, I. de Esch2, H. Verheul1, C.R. Jiménez1
1OncoProteomics Laboratory, Dept. Medical Oncology, VU University Medical Center; 2FEW-VU, Amsterdam
CCA
62. Global profiling of endogenous tyrosine phosphorylation events for identifying aberrant signaling in cancer
Sander R. Piersma1, J.C. van der Mijn2, Barath Kumar1, K.J. Gotink2, M. Labots2, Richard de Haas2, Henk Broxterman2,
Henk Verheul2 and Connie R. Jiménez1
1OncoProteomics Laboratory and 2Angiogenesis Laboratory, Dept. Medical Oncology, VU University Medical Center
VUmc CCA and VHS
Other projects
63. Analysis of bacterial contamination of blood transfusion projects
I. Rood, A. Petterson, P.H.M. Savelkoul
Sanquin Bloodbank
64. Anca-PR-3 vasculitis studie; preventie van recidieven
A.E. Voskuyl
Dep Rheumatology, VU University Medical Center, Amsterdam
65. Assessing the need for isolation in a single room of patients colonized with highly resistant microorganisms
C.M.J.E. Vandenbroucke-Grauls, J.A.J.W. Kluytmans
Dept. of Medical Microbiology and Infection Control, VU University Medical Center
ZonMw
66. Carbapenemase-producing Enterobacteriaceae in The Netherlands: development of phenotypical and molecular
assays for detection and evaluation of the prevalence, risk factors and molecular epidemiology
J.A.J.W. Kluytmans, C.M.J.E. Vandenbroucke-Grauls
ZonMw
67. Cervix cancer proteomics. Unraveling protein expression changes during HPV-induced transformation using a labelfree proteomics approach
C.R. Jimenez1, C. van Alphen1, T.V. Pham1, S.R. Piersma1, P.J.F. Snijders2, R.D.M. Steenbergen2
1OncoProteomics Laboratory, Dept. Medical Oncology, and 2Dept. Pathology, VUmc Cancer Center Amsterdam, VU
University Medical Center, Amsterdam
CCA
68. Characterization of epileptogenic brain networks in primary brain tumor patients
L. Douw1, J.J. Heimans1, F. Bartolomei2,6, J.C. Baayen4, W.P. Vandertop 4, B.W. van Dijk2, D.N. Velis7, M. Klein3,
C.J. Stam2, J.C. Reijneveld1,5
Departments of 1Neurology, 2Clinical Neurophysiology, 3Medical Psychology, and 4Neurosurgery, VU University Medical
Center, 5Department of Neurology, Academic Medical Center, Amsterdam, 6Department of Clinical Neurophysiology,
Hospital de la Timone, Marseille, France, 7Department of Clinical Neurophysiology, Stichting Epilepsie Instellingen
Nederland (SEIN), Heemstede
Nationaal Epilepsie Fonds (NEF), Project NEF 08-08 08-08
69. Characterization of the leukemic stem cell compartment in chronic myeloid leukemia (CML)
J.J.W.M. Janssen, W. Pouwels, B. van Kuijk, A. Zevenbergen, G.J. Schuurhuis, G.J. Ossenkoppele
Dept. of Hematology, VU University Medical Center
Stichting Vanderes
70. CMSB, preventive medicine in rheumatoid arthritis
C. Verweij, J.G. Wesseling, M. Blits, W. Lems
V-ICI
71. Community-associated MRSA: determinants of carriage, transmissibility and virulence
J.A.J.W. Kluytmans, P.H.M. Savelkoul, C.M.J.E. Vandenbroucke-Grauls
ZonMw
72. Cross-talk between TNF and IFN in rheumatidc arthritis
T.D. de Jong1, S. de Ridder1, J. Beliën1, P. Welsing2, J. Luime3. C. Verweij1
1Dept. of Pathology, 2UMCU, 3Emc
CTMM Reumafonds
119
73. Crypton: A genome-based generalized strategy to activate cryptic antibiotic biosynthesis gene clusters in
Actinomycetales
C.M.J.E. Vandenbroucke-Grauls, W. Bitter
Dept. of Medical Microbiology and Infection Control, VU University Medical Center (samenwerking met RUG)
STW Genbiotics grant
74. Curing autoimmune disease. A translational study to autoimmune diseases in the post-genomic era using
inflammatory rheumatic arthritis and myositis as prototypes and learning examples, understanding the molecular
basis of teh differential INFB response in relapsing remitting MS
C. Verweij
MS stichting
75. Development of a decision aid in prostate cancer
Vis, J.A. Nieuwenhuijzen and R.J.A. van Moorselaar
Dept. of Urology, VU University Medical Center, Amsterdam
76. Development of a methodology to characterise the genomic content of lifestock-associated MRSA
P.H.M. Savelkoul, C.M.J.E. Vandenbroucke-Grauls, J.A.J.W. Kluytmans
Agentschap NL
77. Development of screening tests for early detection of CRC
B. Carvalho1, M. van der Wiel1, V. Coupé1, M. van Engeland2, Y. van der Burgt3, W. van Criekinge4, G.A. Meijer
Dept. Of Pathology, VUmc1, MUMC2, LUMC3, MdXHEalth, Univ Gent4
CTMM
78. Diagnostic monitoring of NPC and building a second center of expertise in Indonesia
Gondowiyardjo S1, L. Adham1, A.N. Kurniawan1, J.M. Middeldorp2
1Univ Indonesia, Jakarta, 2Dept of Pathology, VU University Medical Center, Amsterdam
KWF
79. Discontinuation of imatinib in CML patients in continuous complete molecular remission
J.J.W.M. Janssen, B. van Kuijk, G.J. Schuurhuis, J.J. Cornelissen, G.J. Ossenkoppele
KWF
80. Early versus late Mitomycin C instillation in bladder cancer
T. van Ginkel and R.J.A. van Moorselaar
81. EBV markers in CLL cases from Spain
De Sanjose, J.M. Middeldorp
82. EBV-based markers in prognosis of Burkitt
E. Weiderpass, C.J.L.M. Meijer, J.M. Middeldorp
Karolinska Inst
83. E-healt in urology patients
J. Bossenga, E.J.H. Meuleman, A. Vis and R.J.A. van Moorselaar
84. Flowcytometric stem cell assessment for prediction and monitoring of response in nilotinib treated CML patients
J.J.W.M. Janssen, W. Pouwels, B. van Kuijk, A. Zevenbergen, G.J. Schuurhuis, G.J. Ossenkoppele
Dept. Of Hematology, VU University Medical Center, Amsterdam
Novartis Oncology, Arnhem
85. Genomic biomarkers to predict development of RA (VERA, ERA) and therapy responsiveness (ESRA)
J. Lübbers1, A. Voskuyl2, W. Lems2, M. Boers2, D.J. van Schaardenberg3, M. Nurmohamed3, M. Hazes4
1Dept. Of Pathology, 2Dept. Of Rheumatology, VU University Medical Center, Amsterdam, 3Reade/JBI, 4Emc
CTMM
86. Genotyping and phenotyping of distant breast cancer metastases
P. Wesseling1, P. van Diest2, J. Wesseling1
Dept. Of Pathology, 1VU University Medical Center Amsterdam, 2Utrecht Medical Center
KWF
87. ICT and data analysis
J. Beliën, G.A. Meijer
CTMM
88. Identification of chromosomal aberrations driving metastatic colorectal cancer development
B. Ylstra
St. Sacha Swarttouw
89. Identification of clinically relevant genetic aberrations in pediatric glioneuronal tumors
B. Ylstra1, P. Wesseling1, E. Aronica2, Schouten2
Dept. Of Pathology, 1VU University Medical Center Amsterdam, 2Amsterdam Medical Center
Edli Foundation
90. Identification of small non/coding RNAs involved in colorectal adenome to carcinoma progression
B. Diosdado, R.Q.J. Schaapveld1, G.A. Meijer
Dept of Pathology, VU University Medical Center Amsterdam, 1InteRNA Technologies BV
inteRNA
91. IS-pro: A molecular tool for clinical diagnostics of complex microbial communities
D. Budding, P.H.M. Savelkoul
NGI pre-seed grant
120
92. Laboratory tests in primary colorectal cancer
B. Carvalho1, M. van Engeland2, W. Corver3, B. Janssen4, W. van Criekinge5, G.A. Meijer1
Dept. Of 1Pathology, VU University Medical Center, Amsterdam, 2MUMC, 3LUMC, 4ServiceXS, MDXHEalth, Univ. Gent
CTMM
93. Measuring intraprostatic androgen concentrations using LC-MS/MS: from bench to bedside
T. van der Sluis1, H.N. Bui2, J.J.L. Jacobs1, A.A. Geldof1, M.A. Meuleman1, M.A. Blankenstein, L2. Rozendaal3, A.
Heijboer2, R.J.A. van Moorselaar1 and A. Vis1
Dept. of Urology1, Clinical Chemistry2 and Pathology3 VU University Medical Center, Amsterdam
94. Medical technology assessment
C. Uyl, V. Coupé, G.A. Meijer
CTMM
95. Metastatic colorectal molecular laboratory tests
B. Ylstra1, B. Carvalho1, M. van Engeland2, W. Corver3, B. Janssen4, W. van Criekinge5, G.A. Meijer1
Dept. Of 1Pathology, VU University Medical Center, Amsterdam, 2MUMC, 3LUMC, 4ServiceXS, MDXHEalth, Univ. Gent
CTMM
96. Methicillin-resistant Staphylococcus aureus: occupational exposure, dynamics of carriage and associated disease
B. van Cleef, P.H.M. Savelkoul, C.M.J.E. Vandenbroucke-Grauls, J.A.J.W. Kluytmans
ZonMw
97. Multiplex NPC families in Taiwan
A. Hildesheim2, J.M. Middeldorp1
1Dept. Of Pathology, VU University Medical Center Amsterdam, 2 NCI-NIH, USA
RTI, USA
98. Overcoming Temozolomide (TMZ) resistance in glioma
T. Würdinger1, P. Wesseling2
Dept. Of Neurosurgery1 and Pathology2, VU University Medical Center, Amsterdam
St. Stop Hersentumoren
99. Peritoneal metastases from colorectal carcinoma; Diagnostic markers to identify patients that will benefit from
radical surgical resection
E. de Cuba, G.A. Meijer, H.J. Bonjer, E.A. te Velde
Dept. Of Surgery, VU University Medical Center, Amsterdam
100. PET imaging in giant cell vasculitis
KJ Lensen, I Smulders, E Coomans, C vd Laken, A Voskuyl
101. Prediction of progression in low-grade glioma using chromosomal copy number alterations
H.F. van Thuijl1,2, J.J. Heimans1, P. van der Valk2, B. Ylstra2, P. Wesseling2, J.C. Reijneveld1,3
Departments of 1Neurology and 2Pathology, VU University Medical Center, Amsterdam, Department of 3 Neurology,
Academic Medical Center, Amsterdam
KWF Kankerbestrijding VU 2009-4470
102. Prediction of response to drug therapy in advanced colorectal cancer based on DNA copy number profiles of
primary tumors
J. Haan, J.H.J.M. van Krieken, C.J.A. Punt, G.A. Meijer
KWF 2007-3832
103. Projectmanagement
M. van Engeland1, C.J.H. van de Velde2, G.A. Meijer2
Dept of Pathology, MUMC1, VU University Medical Center Amsterdam2
CTMM
104. Protein arrays and metabolite biomarkers to predict development of RA and response to therapy (WP8)Curing
autoimmune disease. A translational study to autoimmune dieseases in the post-genomic era using inflammatory
rheumatic arthritis and mysositis as prototypes and learning examples
M. Blits1, L. Klareskog2, I. Lundberg2, T. Huizinga3, G. Burmester4, A. Voskuyl4, W. Lems4, M. Boers4, D.J. van
Schaardenberg5, M. Nurmohamed5, M. Hazes6, H. Bijlsma7, J. Smolen8, B. Bresnihan9, P.P. Tak10, D. Baeten10, A.
Cope11, W. van den Berg12, W. van Vernrooij12, C. Jorgeson13, T. Saxne13, R. Holmdahl14, S. Rantapää-Dahlqvist15, J.
Vencovsky16, J. Worhtington17, J. van de Winkel18, C. Buckley19, F. Cornelis20, D. Boumpas21, G. Burmester22, C.
Verweij1, T. Hanke23, P. Olofsson24, K. Mignon-Godefroy25, M. Veroordeldonk26
Dept. Of Pathology1 and Rheumatology4, VU Universtiy Medical Center Amsterdam, 2Karolinska Instituted, 3LUMC,
5Reade/JBI, 6Emc, 7UMCURadbruch (Charité, Berlin), 8MUW, Austria), 9SVUH, Ireland, 10AMC, 11Imperial, UK, 12UMCN,
13Inserm, France, 14UNILUND, Sweden, 15UMU, Sweden, 16Inst Rheum, Czech Republic, 17Manc, UK, 18Genmab
Denmark, 19UNIBHAM, UK, 20GenHotel, France, 21Rheumacrete, Greece, 21EULAR, Belgium, 22TeGenero
GermanyOlofsson (ARX, Sweden), 23BMD, France, 24Arthrogen, NL
CTMM EU
105. Reducing CRC death in stage II carcinomas by identifying high/risk stage II cancer patients who could benefit from
adjuvant chemotherapy
B. Diosdado, R.Q.J. Schaapveld1, G.A. Meijer
Dept of Pathology, VU University Medical Center Amsterdam, 1InteRNA Technologies BV
inteRNA
106. Resistance due to extended-spectrum Beta-Lactamases in The Nederlands: the REBEL study
E.A.E. Reuland, , P.H.M. Savelkoul, J.A.J.W. Kluytmans, C.M.J.E. Vandenbroucke-Grauls
ZonMw
107. Response evaluation during targeted therapy
A.J. de Langen, R. Boellaard, A. Vincent, H. van Tinteren, O.S. Hoekstra, R. Boellaard
121
Depts of Nucl Med & PET research, Pulmonology, VU University Medical Center, Dept Biostatistics Neth Cancer Institute,
Amsterdam
108. Tumor profiling of gastrointestinal (i.e. gastric & colorectal) cancer
C. Postma1, A.H. Hardebol1, J.C. Haan1, O. Krijgsman1, J.A.C.M. Goos1,4, A.A. Geldof4, O.S. Hoekstra4, R.P.A.
Brosens1,2, E. Belt1,2, M.A. Cuesta2, E.M.L.V. de Cuba1,2, E. te Velde2, M.Labots3, T. Buffart1,3, H. Verheul3, M.
Tijssen1, S. Mongera1, P.M. Delis-van Diemen1, A. Bolijn1, D. Israeli1, B. Ylstra1, R.J.A. Fijneman1, B. Diosdado1, B.
Carvalho1, N.C.T. van Grieken1, and G.A. Meijer1
1Dept of Pathology, 2Dept of Surgery, 3Dept of Oncology, 4Dept of Nuclear Medicine & PET Research, VU University
KWF, CTMM DeCoDe WorkPackage 5 and 6 2002-2618 / 2004-3051 / 2007-3832 / 2007-3974
109. Understanding the molecular basis of the differential INFB response in relapsing remitting MS
C. Verweij1, Ch. Polman2, J. Killestein2
Dept of 1Pathology, 2 Neurology, VU University Medical Center Amsterdam
MS stichting
110. Validation of citrulline as a marker of small intestine absorption capacity: a pilot study
J.H.C. Peters1, N.J. Wierdsma2, C.J.J. Mulder1, P.A.M. van Leeuwen3 and A.A. van Bodegraven1
1Department of Gastroenterology, Small Bowel Disease Unit, 2Department of Nutrition and Dietetics, 3Department of
Experimental Surgery, VU University medical center, Amsterdam, the Netherlands
Program 4
AML and CML
1. Application of bortezomib in pediatric acute lymphoblastic leukemia
D. Niewerth1, J. van Meerloo1,2, N.E. Franke1, S. Zweegman2, Y.G. Assaraf4, G. Jansen3, G.J.L. Kaspers1, J. Cloos1,2
Depts. of 1Pediatric Oncology/Hematology, 2Hematology and 3Rheumatology, VU University Medical Center,
Amsterdam, 4Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel
Stichting KIKA
2. Characterization of relapsed acute myeloid leukemia
C. Bachas1,2, Z.J. Kwidama1,2, G.J. Schuurhuis2, G.J.L. Kaspers1 J. Cloos1,2.
Depts. of 1Pediatric Oncology/ Hematology and 2Hematology, VU University Medical Center, Amsterdam
KWF KWF 2005-3666
3. Detection of residual leukemic stem cells during minimal residual disease in AML
M. Terwijn, G.J. Ossenkoppele, GJ. Schuurhuis
KWF 2006-3695
4. Discovery by proteomics of factors that regulate therapy resistance in acute myeloid leukemia
S. Zweegman1, F.L. Kessler1, S.R. Piersma2, T.V. Pham2, J. C. Knol2, P. Noordhuis1, J. Cloos1, G.J. Schuurhuis1, C.
Jimenez2
Dept of 1Hematology and 2OncoProteomics Laboratory, Dept. Medical Oncology, VU University Medical Center
Amsterdam
CCA-V-ICI grant
5. Drug resistance in childhood leukemia
N.E. Franke1, J. van Meerloo1,2, D Niewerth1,2, S.E. Verbrugge3, D.P. Geerke4 A. Schimmer5, W.J. Chng6, B.A.C.
Dijkmans3, Y.G. Assaraf7, G.J.L. Kaspers1, G. Jansen3, J. Cloos1,2
Depts. of 1Pediatric Oncology/Hematology, 2Hematology and 3Rheumatology, VU University Medical Center,
Amsterdam, 4Dept. of Medicine, National University of Singapore, 5Princess Margaret Hospital, Ontario Cancer Institute,
Toronto, 6Dept. of Chemistry and Pharmaceutical Sciences, VU University, Amsterdam, 7Dept of Biology, TechnionIsrael Institute of Technology, Haifa, Israel
Stichting Translation Research and ZonMw PV06/08 CCA
6. Identification and characterization of AML (stem) cells responsible for development of relapse
R. Wouters2, C. Bachas1,2, Z.J. Kwidama1,2, G.J. Schuurhuis2, G.J.L. Kaspers1 J. Cloos1,2
Depts. of 1Pediatric Oncology/ Hematology and 2Hematology, VU University Medical Center, Amsterdam
CCA/V-ICI
7. Improvement of diagnosis and monitoring of childhood Acute Lymphoblastic Leukemia for better treatment in
Indonesia
E. Supriyadi1, P. H. Widjajanto1, J.Cloos2,3, A.J.P. Veerman2
Pediatrci Oncology, Gadjah Mada University, Yogyakarta, Indonesia, Depts of 2Pediatric Oncology/Hematology and
3Hematology, VU University Medical Center, Amsterdam
KWF IN-2006-22
8. Protein tyrosine phosphatases as novel treatment targets in acute myeloid leukemia
M. Irandoust1,2, M. Akyuz1,2, E. de Bruijn3, A.J.F. Broekhuizen1,2, G.J.L. Kaspers1, E. Cuppen3, J. Cloos1,2
Depts. of 1Pediatric Hematology/Oncology and 2Hematology, VU University Medical Center, Amsterdam, 3Genomic
Biology Department, Hubrecht institute, Utrecht
Stichting KiKa
9. Targeting of CLEC12A positive AML stem cells with CR2357 and antibody-drug conjugates
P. Noordhuis, M. Terwijn, A.R. Rutten, G.J.Ossenkoppele, G.J.Schuurhuis
Dept. of Hematology, VU University Medical Center, Amsterdam
Crucell Nederland
10. The function of EVI-1 in Acute Myeloid Leukemia; Leukemic stem cells and chemotherapy resistance
B. Venniker-Punt, D. de Leeuw, A. Rutten, P. Merle, G. Ossenkoppele, G.J. Schuurhuis, L. Smit
Department of Hematology University Medical Center, Amsterdam, The Netherlands
Interna and St. Vu Steunfonds Hematologie
11. The identification of biomarkers/drugtargets specific for leukemic stem cells of Acute Myeloid Leukemia
H. Verhagen, M. Terwijn, A. Rutte, B. Ylstra, R. Menezes, G. Ossenkoppele, G.J. Schuurhuis, L.Smit
122
Department of Hematology, Microarray Facility, department of Pathology, Department of Biostatistics. VU University
Medical Center, Amsterdam, The Netherlands
CCA/V-ICI project
12. The identification of microRNA(s) (signatures) for leukemic stem cells of Acute Myeloid Leukemia and Chronic
Myeloid Leukemia
D. de Leeuw, F. Denkers, G.J. Schuurhuis, G. Ossenkoppele, L. Smit
Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands
AICR and Interna
13. The role of impaired FPGS splicing in methotrexate response in childhood acute lymphoblastic leukemia
A.M. Wojtuszkiewicz1,2, G.J. Peters3, G. Jansen4, Y.G. Assaraf5, G.J.L. Kaspers1, J. Cloos1,2
Oncology/Hematology, 2Hematology, 3Medical Oncology and 4Rheumatology, VU University Medical Center, Amsterdam,
5Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel
Stichting KIKA (kinderen kankervrij)
14. The role of minimal residual disease, and leukemic stem cells herein, in clinical decision making
W. Zeijlemaker, A. Kelder, G.J. Schuurhuis, G.J. Ossenkoppele
Dept. Of Hematology, VU University Medical Center, Amsterdam
St. VU Steunfonds Hematologie
Brain
15. Targeted therapy in pediatric brain tumors
D.G. van Vuurden1,4, E. Hulleman2,4, P. van der Stoop2,4, T. Wurdinger2,4, 5, M. Irandoust1,3, G.J.L. Kaspers1, J.
Cloos1,3
Depts of 1Pediatric Oncology/ Hematology, 2Neurosurgery, 3Hematology and 4Neuro-Oncology Research Group, VU
University Medical Center, Amsterdam, 5Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard
Medical School, Boston, MA. VU University Medical Center, Amsterdam
VONK
Combined radiotherapy with conventional chemotherapy and molecular targeted agents
16. Combined radiotherapy with conventional chemotherapy and molecular targeted agents
S. Senan, F.J. Lagerwaard, J.S.W. Lind, E.C.J. Phernambucq, E.F. Smit, V.L.J.L. Thijssen, B.J. Slotman
Departments of Radiation Oncolog, Pulmonology and Medical Oncology, VU University Medical Center, Amsterdam
Co-morbidity RA
17. Cardiovascular disease and Rheumatoid Arthritis
A. van Sijl1,2, M. Peters1,2, M.T. Nurmohamed1,2,4, A.E. Voskuyl2, C.D.A. Stehouwer4, M. Visser5, W.F. Lems3, R.J.
van de Stadt2, M.H.M.T. de Koning2, M. Boers6, B.A.C. Dijkmans1,2,3
Depts of 1Rheumatology, VUMC, 2Jan van Breemen Institute, 3Slotervaart Hospital, 4Dept of Internal Medicine VU
University Medical Center, 5Institute for Research in Extramural Medicine, 6Dept of Clinical Epidemiology, VUMC
Imaging: Colorectal tumours
18. Treatment optimization of cetuximab in patients with metastatic colorectal cancer based on tumor uptake of 89Zrlabeled cetuximab assessed by PET
C.W. Menke-van der Houven van Oordt, G.A.M.S. van Dongen, O.S. Hoekstra, J.J. van der Vliet, M. Labots, C. van
Montfrans, A. Beeker, H.M.W. Verheul
Dept. of Medical Oncology VU University Medical Center Amsterdam
Imaging: Paediatric tumours
19. Treatment strategies and new diagnostic tools for malignant pontine gliomas
M.H.A. Jansen1, D.G. van Vuurden1, W.P. Vandertop2, G.A.M.S. van Dongen3, O.S. Hoekstra4, G.J.L. Kaspers1
1Dept Pediatrics, Pediatric Oncology/-Hematology, 2Dept Neurosurgery, 3Dept Otolaryngology/Head and Neck Surgery
and Nuclear Medicine & PET research, 4Dept Nuclear Medicine, VU University Medical Center, Amsterdam
VONK, Semmy Foundation
Imaging: Rheumatoid diseases
20. Clinical applications of Positron Emission Tomography for inflammatory rheumatic diseases
S.T.G. Bruijnen, J. van der Laken, A.E. Voskuyl, O.S. Hoekstra, B.A.C. Dijkmans
Dept. Of Reumatology, VU University Medical Center, Amsterdam
Beheer BV gelden
21. Imaging and targeting of macrophage folate receptor-beta in rheumatoid arthritis
K. Weijers1, Y.Y.J. Gent1, G. Jansen1, C.F.M. Molthoff2, A.D. Windhorst2, J.W. van der Heijden1, A. Voskuyl1, P.S.
Low3, M. Ratnam4, Y.G. Assaraf 5, A.A. Lammertsma2, B.A.C. Dijkmans1, and C.J van der Laken1
Depts. of 1Rheumatology and 2PET-Center/Nuclear Medicine, VU University Medical Center, Amsterdam, The
Netherlands, 3Endocyte, West Lafayette, IN, USA, 4Dept of Biochemistry and Molecular Biology, Medical University of
Toledo, Toledo, OH. U.S.A., 5Dept. of Biology, The Technion, Israel Institute of Technology, Haifa, Israel
Nationaal Reumafonds NRF-09-404
Improvement of treatment of head and neck cancer
22. Electrochemotherapy
D.H. Heuveling, R. de Bree
IGEA
23. Hypothyroidism after treatment for laryngeal cancer
A.M. Lo Galbo, R. de Bree, C.R. Leemans
24. Improvement of treatment of head and neck cancer. General aspects.
R. de Bree1, P. Doornaert2, I. van der Waal3, J. Buter4 , C.R. Leemans1
Depts. of 1Otolaryngology/Head-Neck Surgery, 2Radiation Oncology, 3Oral and Maxillofacial Surgery, 4 Medical
Oncology, VU University Medical Center, Amsterdam
25. Salvage treatment after (chemo)radiation
L. van der Putten, C.R. Leemans, R. de Bree
Oncolytic adenovirus
123
26. Enhancement of the oncolytic potency of conditionally replicative adenoviruses
W. Dong1, H. van Wijngaarden1, M. Cascallo2, W.R. Gerritsen3, R. Alemany2, J.J.M. Meulenberg1, V.W. van
Beusechem1,3
1ORCA Therapeutics, Amsterdam, The Netherlands; 2Translational Research Laboratory, IDIBELL-Institut Català
d’Oncologia, Barcelona, Spain; and 3Department of Medical Oncology, VU University Medical Center, Amsterdam
27. Exploiting miRNA to enhance oncolytic adenovirus potency
J.W.H. van Ginkel1, C. Vermeulen2, J. Hodzic2, A. Vermeulen3, J. Karpilow3, J.J.M. Meulenberg1, V.W. van
Beusechem1,2
1ORCA Therapeutics, Amsterdam, The Netherlands; 2Department of Medical Oncology, VU University Medical Center,
Amsterdam, The Netherlands; 3Thermo Fisher Scientific, Dharmacon RNAi Technologies, Lafayette, CO, USA.
28. Identification of virus inhibitors in cancer cells by RNA interference screening
C. Vermeulen1, I.H. van der Meulen-Muileman1,2, R.N. Lalai1, W.R. Gerritsen1, V.W. van Beusechem1,2.
1Department of Medical Oncology and 2RNA Interference Functional Oncogenomics Laboratory, VU University Medical
Center, Amsterdam, The Netherlands
Technology foundation STW 7710
29. Virotherapy of glioblastoma multiforme using an infectivity-enhanced selectively replication-competent adenovirus
V.W. van Beusechem1, M.L.M. Lamfers2, J.M. Amado de Azevedo1, S. Idema3, C.M.F. Dirven2, W.R. Gerritsen1, W.P.
Vandertop3, D.P. Noske3
Depts. of 1Medical Oncology and 3Neurosurgery, VU University Medical Center, Amsterdam; 2Dept. Neurosurgery,
Erasmus MC, Rotterdam
ZonMw Translationeel Gentherapeutisch Onderzoek 43200003
RNai
30. Identification of genes involved in resistance of lung cancer cells to cisplatin
E. Siebring-van Olst1, I. Kotov2, R.X. de Menezes3, T. Marti2, R. Stahel2, E.F. Smit1, V.W. van Beusechem4,5
Depts. of 1Pulmonary Diseases, 3Epidemiology and Biostatistics, and 4Medical Oncology, and 5RNA Interference
Functional Oncogenomics Laboratory, VU University Medical Center, Amsterdam; 2Laboratory of Molecular Oncology,
University Hospital Zurich, Switzerland
Foundation Avanti STR / Walter Bruckerhoff Stiftung
31. Identification of genes involved in resistance of prostate cancer cells to irradiation
J. Hodzic1, B. van Triest2, A. Geldof3, R.X. de Menezes4, W.R. Gerritsen1, M. Verheij2, V.W. van Beusechem1,5
Departments of 1Medical Oncology, 3Urology, 4Epidemiology and Biostatistics and 5RNA Interference Functional
Oncogenomics Laboratory, VU University Medical Center, Amsterdam; 2Department of Radiotherapy, The Netherlands
Cancer Institute, Amsterdam
CCA, Avanti STR
Symptoms and symptomatic treatment of cerebral glioma
32. Correlation between SV2A expression in tumour tissue and efficacy of levetiracetam in glioma patients with
epilepsy
M. de Groot1, J.J. Heimans1, E. Aronica5, C.J. Vecht6, M. Klein3, C.J. Stam2, J.C. Reijneveld1,4
Departments of 1Neurology, 2Clinical Neurophysiology, and 3Medical Psychology, VU University Medical Center,
Amsterdam, Departments of 4 Neurology and 5 Pathology, Academic Medical Center, Amsterdam, and 6Department of
Neurology, Medical Center ‘Haaglanden’, The Hague
UCB Pharma Nederland BV
Systemische sclerose
33. Capillair microscopie bij sclerodermie
H.M.A. Hofstee, E.H. Serne, I. Smulders, A.E. Voskuyl
Other projects
34. A multicenter, randomized phase II trial of paclitaxel plus bevacizumab versus paclitaxel, bevacizumab plus
capecitabine in HER2-negative locally recurrent or metastastic breast cancer
S.W. Lam, A.H. Honkoop, S. de Groot, S v.d. Wildt, H. van Tinteren, E. Boven
Depts. of Medical Oncology, VU University Medical Center and BOOG Study Center Amsterdam
Industry
35. Absorptiometry in ICU patients
R.J.M. Strack van Schijndel1, N.J. Wierdsma2, A.A. van Bodegraven3
1Department of Intensive Care, 2Department of Nutrition and Dietetics and 3Department of Gastroenterology, Small
Bowel Disease Unit VU University medical centre, Amsterdam
36. Activity of Novel Irreversible Inhibitors of Epidermal Growth Factor Receptor in Non Small Cell Lung Cancer
E. Galvani,a,b C. Carmi,c F. Vacondio,c A. Cavazzoni,a R.R. Alfieri,a E. Giovannetti,b M. Mor,c P.G. Petronini,a G.J.
Peters.b
a University of Parma, Department of Experimental Medicine, Italy;
bVU University Medical Center, Department of Medical Oncology, Amsterdam, The Netherlands;
c University of Parma, Pharmaceutical Department, Italy
37. Aldehyde Dehydrogenase Activity (ALDH) is higher in normal Hematopoietic Stem Cells compared to Leukemic Stem
Cells in Acute Myeloid Leukemia
G.J. Schuurhuis, L.A. Min, H. Meel, R. Wouters, N. de Jonge, M. Terwijn, A. Kelder, A.N. Snel, G.J. Ossenkoppele, L.
Smit
Department of Hematology, VU University Medical Center, Amsterdam, Netherlands
38. Anti-inflammatory therapy and biomarker analysis during peritoneal dialysis
A. Stavenuiter, M. Schilte, K. Farhat, N. Paauw, J. van den Born, P.M. ter Wee1, R.H.J. Beelen
1Dept. Nephrology, VU University Medical Center, Amsterdam, The Netherlands
Dutch Kidney Foundation, Marie Curie ITN
39. Assessment of renal function in pediatric oncology using new renal function markers
H.N. Blufpand1, F.C.H. Abbink1, B. Stoffel-Wagner3, G.J.L. Kaspers1, A. Bökenkamp2
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1Pediatric Oncology, 2Pediatric Nephrology VU University Medical Center and 3Clinical Chemistry and Clinical
Pharmacology, Bonn University Medical Center
VUmc Childhood Cancer Research Foundation – VONK
Autologous stemcell transplantation in systemic sclerosis (ASTIS); a multinational RCT
J.M. van Laar, D. Farge, A. van de Loosdrecht, P. Huijgens, A.E. Voskuyl, A. Tyndall
Dept. Of Rheumatology and Haematology, VU University Medical Center Amsterdam
Bioluminescence imaging for discovery and characterization of novel glioma therapeutics
C.E. Badr1,2,3, J. Niers1,2,3, W.P. Vandertop1,2, D.P. Noske1,2, T. Wurdinger1,2,3, B.A. Tannous3
Depts. of 1Neurosurgery, 2Neuro-oncology Research Group, VU University Medical Center, Amsterdam.3Molecular
Neurogenetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA
Biomarkers as predictors for the effect of anti-angiogenic therapy
L.Vroling, K.Hoekman, Y.Yuana, R. de Haas, V.W.M. van Hinsbergh1, E. Boven, G.J. Schuurhuis2, H.J.Broxterman
Depts. of Medical Oncology, 1Physiology and 2Hematology, VU University Medical Center
EU (FP6): Integrated Project: Angiotargeting 504743
Brain tumor miRNA in the development of 'genetic' chemotherapeutics
R. J. A Nilsson1,2, M. Smits1,2, S. van Rijn1,2 , P. van der Stoop1,2, J. Berenguer1,2, W.P. Vandertop1,2, D.P.
Noske1,2, T Wurdinger1,2,3
Depts. of 1Neurosurgery, 2Neuro-oncology Research Group, VU University Medical Center, Amsterdam. 3Molecular
NWO-VIDI, Van Reekum/van Moorselaar stichting, CCA/STR, Swedish Research Council
Brainstem tumors: development of anti-tumor drugs for convection enhanced delivery
V. Caretti1,2,3, E. Hulleman2,3, J. Cloos2,3, W.P. Vandertop1,3, G.J.L. Kaspers2,3, D.P. Noske1,3, T. Wurdinger1,3,4
Depts. of 1Neurosurgery, 2Pediatric Oncology/ Hematology, 3Neuro-oncology Research Group ,VU University Medical
Center, Amsterdam. 4Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard Medical School,
Boston, MA
VONK/Semmy/Stichting Egbers
Chronological or random reading of radiographs in long term follow-up studies of Rheumatoid Arthritis?
L. Van Tuyl,1,2 D.M.F.M van der Heijde, 3 M. Boers (PI)1,2
1. Dept of Clinical Epidemiology and Biostatistics; 2. Dept of Rheumatology; VUmc; 3. Dept of Rheumatology, Leiden
UMC
Reumafonds
Clinical evaluation of the underlying mechanisms of targeted therapy related toxicities
M. Rovithi1, H. Berkhof2, T.D. de Gruijl1, C.R. Jimenez1, M.Labots1, G.A. Meijer3, G.J. Peters1, S.Santegoets1, A.A.
van Bodegraven4, N.C.T van Grieken3, C. van Montfrans5, A.J.M van den Eertwegh1, H.M.W. Verheul1
Depts. of 1Medical Oncology, 2Biostatistics, 3 Pathology, 4 Gastroenterology and 5 Dermatology of the VU University
Medical Center
Compliance with childhood cancer treatment in Kenya
S. Mostert1, F. Njuguna2, L.J.P.A. Kemps1, M.N. Sitaresmi3, R.M. Strother4, J. Skiles4, R. Vreeman4, L.M. Aluoch2,
N.G. Buziba2, G.J.L. Kaspers1
1 Pediatric Oncology-Hematology and Doctor2Doctor program, VU University Medical Center, Amsterdam, the
Netherlands, 2 Pediatrics, Moi Teaching and Referral Hospital, Eldoret, Kenya, 3 Pediatrics, Dr Sardjito Hospital,
Yogyakarta, Indonesia, 4 Pediatrics and USAID-Academic Model Providing Access to Healthcare (AMPATH) program,
Indiana University School of Medicine, Indianapolis, United States of America
Development of DCOne/MUTZ-3 and novel AML-derived cell lines for DC-based allogeneic tumor vaccination
R. van de Ven1, S.J.A.M. Santegoets1, D. Oosterhoff2, M. Koppes3, P.J.G.T.B. Wijnands2, A. Reurs2, M. Meerendonk2,
J. Kaspers2, S. van Wetering2, A.J.M. van den Eertwegh1, Rik J. Scheper1,4, G.J. Ossenkoppele3, A.A. van de
Loosdrecht3, A.M. Kruisbeek2, T.D. de Gruijl1
Department of 1Medical Oncology, 2DC Prime BV, and the Departments of 3Hematology and 4Pathology, VU University
Medical Center, Amsterdam, The Netherlands.
DC Prime, Biopartner FSG & Senter Grant, ZonMW Translationeel Research Grant 40-41200-98-9106
Development of preclinical pediatric brain tumor imaging models
L. Hiddingh1,2,3, V. Caretti1,2,3, T. Lagerweij1,2,3, E. Hulleman1,2,3, G.J. Kaspers1, W.P. Vandertop2, C. Molthoff4,
B.A. Tannous4, D. Noske2,3, T. Wurdinger2,3,5
Depts of 1Pediatric Oncology/ Hematology, 2Neurosurgery, 3Neurooncology Research Group, VU University Medical
Center, 4VU University RNC, 5Massachusetts General Hospital and Harvard Medical School, Boston, MA
Stichting KiKa
Diffuse intrinsic pontine gliomas: towards new treatment strategies
V. Caretti1,2,3, D.P. Noske2,3, W.P. Vandertop2, G.J.L. Kaspers1, T. Wurdinger2,3,4
Departments of Pediatric Oncology1 and Neurosurgery2, VU University Medical Center Amsterdam, Neuro-oncology
Research Group, Cancer Center Amsterdam3, Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard
Medical School, Boston, MA4.
Elucidating TMZ resistance in glioma
L. Hiddingh1,2,3, G.J. Kaspers1, W.P. Vandertop2, P. Wesseling4, B.A. Tannous5, D. Noske2,3, J. Jeuken4, T.
Wurdinger2,3,5
Depts of 1Pediatric Oncology/ Hematology, 2Neurosurgery, 3Neurooncology Research Group, VU University Medical
Center, 4Pathology, RUNMC, 5Massachusetts General Hospital and Harvard Medical School, Boston, MA
Stichting www.stophersentumoren.nl
Epstein barr virus activation and cytolytic antivirual therapy in nasopharyngeal patients
O. Ramayanti1, A.E. Greijer1, I.B. Tan2, J. Kurnianda3, J.M. Middeldorp1
1Dept of Pathology, VU University Medical Center, 2Dept. Of Head and Neck Surgery & Medical Oncology, NKI,
Amsterdam, 3Dept Medicine, Gadjah Mada University
KWF VU 2010-4809
Evaluation of (neuro)toxicity of systemic anti-cancer therapy and neuroprotection
T.J. Postma1, A.A. Geldof2, P.C. Huijgens3, N.K. Aaronson6, G.J. Peters4, B.J. Slotman5, J.J. Heimans1
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Departments of 1Neurology, 2Endocrinology, 3Hematology, 4Medical Oncology, 5Radiotherapy, VU University Medical
Center, Amsterdam, Department of 6Psychosocial Research and Epidemiology, The Netherlands Cancer Institute,
Amsterdam
EVIDENCE: European observational study on the burden of disease associated with the use of NSAIDs in
rheumatology
1A. Lanas, 2M. Boers
Dept of Reumatology, 1Zaragoza, Spain, 2VU University Medical Center Amsterdam
AstraZeneca international
Experimental therapy rationale for prostatic cancer
A.A. Geldof1,2, JJL Jacobs1, I.V. Bijnsdorp1, P. J. Frantzen1 , A. Vis1 and R.J.A. van Moorselaar1
Depts. of 1Urology and 2Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam
Exploring the role of endothelial galectins in tumor angiogenesis
I. Schulkens1, R. Heusschen1, A.M. Dingemans2, V. Van den Boogaart2, H.M. Verheul1, A.W. Griffioen, V.L.J.L.
Thijssen1,3
Depts. of 1Medical Oncology, VU University Medical Center, 2Pulmonology, Maastricht University Medical Cencer,
Maastricht, and 3Radiotherapy, VU University Medical Center
KWF 2009-4358
Gemcitabine and PI3Kinase-Akt pathway inhibition to enhance radiotherapy in human glioblastoma multiforme
(GBM)
M El-Naggar, C Fedrigo, P. Sminia, GJ Peters
Dept. Of Medical Oncology, VU University Medical Center, Amsterdam
Human pharmacokinetics (PK) of selected tyrosine kinase inhibitors (TKI) in relation to transport characteristics in
a polarized gut epithelium model system
R. Honeywell; C. Fatmawati; M. Boeddha; I. Kathmann; N. Losekoot; E. Giovannetti; H.M. Verheul, E.F. Smit; G.J.
Peters
Dept. Of Medical Oncology, VU University Medical Center, Amsterdam
Identification of targeted therapies for anaplastic large cell lymphoma based on apoptosis expression profiles
S. Cillessen, G. Ossenkoppele, C. Meijer
KWF
Image-guided radiotherapy (IGRT)
S. Senan, W.F.A.R. Verbakel, M. Dahele, J.R. van Sörnsen de Koste, P. Doornaert, J.P. Cuijpers, F.J. Lagerwaard, C.L.
Ong, C.J. Haasbeek, F.O.B. Spoelstra, B.J. Slotman
Departments of Radiation Oncology, VU University Medical Center, Amsterdam
Immune correlates of clinical response and survival in castration resistant prostate cancer patients treated with
Prostate GVAX and anti-CTLA4 immunotherapy
S.J.A.M. Santegoets2, A.J.M. van den Eertwegh1, A.G.M. Stam2, S.M. Lougheed1, H. Gall1, P.E.T. Scholten2, B.M.E. von
Blomberg2, E. Hooijberg2, K. Jooss4, N. Sacks4, K. Hege4, I. Lowy5, R.J. Scheper2, W.R. Gerritsen1, T.D. de Gruijl1
Departments of 1Medical Oncology and 2Pathology of the VU University medical center, Amsterdam, The Netherlands;
3Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA; 4Cell Genesys Inc.,South San
Francisco, CA; 5Medarex, Bloomsbury, NJ
Prostate Cancer Foundation Research Award, Dutch Cancer Society KWF-VU 2006-3697
Immunogenetic and therapeutic aspects of Autoimmune hepatitis
N.M.F. van Gerven1, B.J. Verwer1, Y.S. de Boer1, C.J.J. Mulder1, E. Bloemena2, G. Kraal3, C.M.J. van Nieuwkerk1, G.
Bouma1
1. Department of Gastroenterology and Hepatology, VU University Medical Center, 2. Department of Pathology, VU
University Medical Center, 3. Department of Molecular Cell Biology and Immunology, VU University Medical Center
Immunomodulation in melanoma sentinel lymph node
B.D. Koster1, M.F.C.M. van den Hout2, R. van de Ven1, B.J.R. Sluijter3, S.M. Lougheed1, S.J.A.M. Santegoets1, P.A.M.
van Leeuwen3, S. Meijer3, R.J. Scheper2, P. van den Tol3, A.J.M. van den Eertwegh1, T.D. de Gruijl1
Departments of 1Surgical Oncology, 2Medical Oncology, and 3Pathology, VU University Medical Center, Amsterdam, The
Netherlands
Harry J. Lloyd Charitable Trust, Heelkundefonds
Improving conventional immunomodulating thiopurine and methotrexate therapy in inflammatory bowel disease
M.L. Seinen, A.A. van Bodegraven, G.J. Peters, C.J.J. Mulder
Dept. Of Gastroenterology and Medical Oncology, VU University Medical Center
Industry: HLW bv, Helmond
Individualized treatment of patients with advanced colorectal cancer based on miRNA expression profiling
M. Neerincx1, T.E. Buffart1, B. Diosdado2, T. Pham1, H. Dekker1, D. Sie2, C. Verhoef3, G.A. Meijer2, H.M.W. Verheul1
1 Dept. of Medical Oncology VU University Medical Center Amsterdam, 2 Dept. of Pathology VU University Medical
Center Amsterdam, 3 Dept. of Surgical Oncology Erasmus Medical Center Rotterdam
Innovative techniques for intracranial stereotactic radiotherapy
Lagerwaard FJ, Meijer OWM, Haasbeek CJA, Vandertop WP, Baaijen JC, van den Berg R, Postma TJ, Leemans CR,
Slotman BJ
Depts. of Radiation Oncology, Neurosurgery, Radiology, Otolaryngology/Head and Neck Surgery and Neurology, VU
University Medical Center, Amsterdam
Varian - RapidArc
Is c-Abl a potentail target for therapy in Enteropathy Associated T-cell Lymphomas?
M. Radersma1, C.J.L.M. Meijer2, O.J. Visser3, B.M.E. von Blomberg2, G. Bouma1, C.J.J. Mulder1, S.A.G.M. Cillessen2
Depts. of 1Gastro-enterology and Hepatology,2Clinical Pathology, 3Hematology, VU University Medical Center,
Amsterdam
MLDS grant WO-9-28
Kinase activity of tumor-derived exosomes as a potential biomarker for response to treatment
J.C. van der Mijn1, C.R. Jimenez1, S.R. Piersma1, H. Dekker1, M. Labots1, L.M. Schutte1, E.F. Smit2, H.J.
Broxterman1, B.A. Tannous1, T. Wurdinger3, H.M.W. Verheul1
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Depts. of 1Medical Oncology, 2Pulmonology 3Neurosurgery of the VU University Medical Center and 4Neurogenetics unit,
Harvard Medical School, Charlestown (USA)
Leukemia associated antigen loading of dendritic cells for vaccination of acute myeloid leukemia patients
J.M. Ruben1, W.A. van den Ancker1, T,D de Gruijl2, T.M. Westers1, G.J. Ossenkoppele1, H.J. Bontkes1, A.A. van de
Loosdrecht1
Departments of Hematology1 and medical oncology2, Cancer Center Amsterdam, VU University Medical Center
Modulation of miRNAs in glioma stem-like cells
S. van Rijn1,2, M. Smits1,2, J. Nilsson1,2, D.P. Noske1,2, T. Würdinger1,2,3
1Neuro-oncology Research Group, 2Department of Neurosurgery, VU University Medical Center, 3Molecular
CCA/STR funding
Molecular basis of sensitivity/resistance for folate antagonist and experimental targeted drugs
G. Jansen1, J.W. van der Heijden1, R. Oerlemans1, W.F. Lems1, R.J. Scheper2, J. Cloos3, N.E. Franke3, S.E.
Verbrugge1, R. Mauritz4, C.L. Verweij1,2, R. de Jonge5, G.L. Scheffer2, G.J. Peters4, Y.G. Assaraf 6 and B.A.C.
Dijkmans1
Depts. of 1Rheumatology, 2Pathology, 3Pediatric Oncology and 4Medical Oncology, VU University Medical Center,
Amsterdam, The Netherlands, 5 Dept. of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands,
6Dept. of Biology, The Technion, Israel Institute of Technology, Haifa, Israel
Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A (DZNeP)
with gemcitabine in pancreatic cancer cells
A. Avan1,* F. Crea2,* E. Paolicchi2,* N. Funel3, E. Galvani1, V.E. Marquez4, R. Honeywell1, R. Danesi2, G.J. Peters1,#
E. Giovannetti1
1Department of Medical Oncology, VU University Medical Center, Amsterdam, 2Department of Internal Medicine,
University of Pisa, Italy; 3Department of Surgery, University of Pisa, Italy; 4NIH, Frederick, MD, US
New therapy for Epstein-Barr virus driven tumours by targeting the virus itself
Z. Novalic1, A.E. Greijer1, I.B. Tan2, J.P. de Boer2, J.M. Middeldorp1
1Dept of Pathology, VU University Medical Center, 2Dept. Of Head and Neck Surgery & Medical Oncology, NKI,
Amsterdam
ZonMw
Nieuwe behandelingsmogelijkheden bij longkankerpatienten met een K-RAS mutatie
W.W. Mellema, E.F. Smit
Dept. Pulmology, VU University Medical Center, Amsterdam
Optimalisation of immunomodulating therapies in IBD treatment
D.P. van Asseldonk1, K.H.N. de Boer1, C.J, Mulder1, A.A. van Bodegraven1
Dept. of 1Gastroenterology, VU University Medical Center
Gastrostart
Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic RCC
L. Huijts, J.J. van der Vliet, T.D. Gruijl, H. Verheul
Dept of Medical Oncology, VU University Medical Center, Amsterdam
Photoimmunodetection of colorectal cancer
M. Ankersmit1, DA van Dam1, MHGM van der Pas1, EA te Velde, E. De Cuba, GAMS van Dongen2, WJHJ Meijerink1
Depts of 1Gastro-intestinal Surgery, 2Nucleaire Geneeskunde en PET research, VU University Medical Center
Prediction of response to radiotherapy with concomitant and adjuvant Temozolomide in glioblastoma patients with
serum proteomics
M.E. Van Linde1#, J.C. van der Mijn1#, J.C. Knol1, L.E. Wedekind3, T. Pham1, J.C. Reijneveld2, C.R. Jimenez1,
H.M.W. Verheul1
Depts. of 1Medical Oncology, 2Neurology and 3Neurosurgery of the VU University Medical Center, # contributed equally
Promoting antitumor immunity by specific tumor-targeting of iNKT cells
T.D. de Gruijl1, G.A.M.S. van Dongen, J.J. van der Vliet1
1Dept. Of Medical Oncology and 2Otolaryngology/Head-Neck Surgery, VU University Medical Center, Amsterdam
ZonMw
Prospective Validation of Soluble Biomarkers as Predictors of Structural Damage in Rheumatoid Arthritis (BIODAM)
G. Wells (Canada), J. Bathon (USA), C. Bingham (USA), V. Bykerk (Canada), M. Ostergaard (Denmark), T. Kvien
(Norway), M. Boers (Netherlands), D. Aletaha (Austria), P.P. Tak (Netherlands), O. Fitzgerald (Ireland), C. Ritchlin
(USA), P. Mease (USA), H. El-Gabalawy (Canada), W. Lems (Netherlands), D.J. van Schaardenburg (Netherlands), H.
Berner Hammer (Norway), M. Backhaus (Germany), B. Combe (France), G. Ferraccioli (Italy).
OMERACT Biomarker working group
Abbott
Proteasome inhibitor targeting of the (immuno)proteasome: effects on immune effector cells and therapeutic
consequences for cancer and chronic inflammatory diseases
S.E. Verbrugge1, T.D. de Gruijl2, R.J. Scheper3, E. Chan4, C.J. Kirk4, J. Cloos5, Y.G. Assaraf 6, B.A.C. Dijkmans1, and
G. Jansen1
Depts. of 1Rheumatology, 2Medical Oncology, 3Pathology, 5 Pediatric Oncology, VU University Medical Center,
Amsterdam, The Netherlands, 4Onyx Pharmaceuticals, South San Francisco, USA. 6Dept. of Biology, The Technion, Israel
Institute of Technology, Haifa, Israel.
V-ICI Pro07/36
Radiation and targeted therapy of brain tumours
P. Sminia1,K .A. van Nifterik1,6,7, J. van den Berg1, N. Ameziane2, L.J.A. Stalpers6, T.J.M. Hulsebos7, S. Leenstra8, P.
van der Valk4, M.V.M. Lafleur1, R.D.M. Steenbergen3, B.J. Slotman1
Depts. 1Radiation Oncology, 2Oncogenetics, 3Molecular Pathology, 4Pathology, 5Dept Medical Oncology, VU University
Medical Center, Depts. 6Radiation Oncology, 7Neurogenetics, Academic Medical Center, Amsterdam; 8Dept.
Neurosurgery, St. Elisabeth Ziekenhuis,Tilburg
KWF VU2000-2149
Resistance to proteasome inhibitors in cancer and reumatoid arthritis
B. Dijkmans1, T.D. de Gruijl2, R.J. Scheper3, G. Jansen1
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1Dept. Of Reumatology, 2Medical Oncology and 3Pathology, VU University Medical Center, Amsterdam
V-ICI
Resistance to receptor tyrosine kinase inhibitors
H.J. Broxterman, K.J. Gotink, M. Labots, R.R. de Haas, H. Dekker, V. van Beusechem, R.J. Honeywell, G.J. Peters, H.M.
Verheul
Dept. of Medical Oncology, VU University Medical Center
Risk and Benefit of Glucocorticoid Therapy in Rheumatoid Arthritis: A systematic review and GRADE approach to
the body of evidence from prospective studies
S. Tarp Jensen1,2, E.M. Bartels1, H. Bliddal1,3,4, M. Boers5, D.E. Furst6, J.R. Kirwan7, B. Danneskiold-Samsøe1,3,4, M.
Rasmussen2, R. Christensen1,8
1.Parker Institute (MSU), Copenhagen Univ Hosp Frederiksberg Denmark, 2. Fac Pharmaceutical Sciences, Univ
Copenhagen, Denmark, 3. Center for Sensory-Motor Interaction, Aalborg University, Denmark, 4. Fac Health & Science,
Univ of Copenhagen, Denmark, 5. Dept Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 6.
Univ California, Los Angeles, USA, 7. Univ Bristol, Bristol, UK,
8. Inst Sports Science and Clinical Biomechanics, Univ of Southern Denmark, Odense M, Denmark.
Mundipharma International
Role of flow cytometry in the diagnosis and prognostication of myelodysplastic syndromes
C. Alhan, T.M. Westers, C. Cali, K. Vandenberghe, K. Schouten, G.J. Ossenkoppele, A.A. van de Loosdrecht
Dept. of Hematology, VU University Medical Center, Amsterdam
VUmc, dept. of Hematology/Stichting Hematologie Fonds, Celgene/Roche as part of HOVON89
Sensitivity of pediatric high-grade glioma to chemotherapy
Veringa S.J.E.1, van Vuurden D.G.1, D.P. Noske2, W.P. Vandertop2, T. Wurdinger2, G.J.L. Kaspers1, E. Hulleman1
Depts of 1Pediatric Oncology/ Hematology, and 2Neurosurgery, VU University Medical Center, Amsterdam
EDLI foundation
Sensitization towards TRAIL-induced apoptosis in acquired bortezomib resistant A549 cells is not mediated by
downstream apoptotic signalling
L.H.A.M. de Wilt1, G.J. Peters1, S. de Jong3, G. Jansen2, F.A.E. Kruyt3
1Department of medical oncology and 2department of Rheumatology, VU University Medical Center, Amsterdam, The
Netherlands; 3Department of medical oncology, University Medical Center Groningen, University of Groningen,
Groningen, The Netherlands
Shared decision-making in early-stage lung cancer
DRM Timmermans1, S Senan2, W Hopmans1-2, OC Damman1, BJ Slotman2, EF Smit3, CJA Haasbeek2
¹Department of Public and Occupational Health and the EMGO+ Institute for Health and Care Research, 2 Radiation
Oncology, Pulmonology3, VU University Medical Centre, Amsterdam, the Netherlands
Small molecule bioluminescent screening for novel therapeutics for pediatric brain tumors
E. Hulleman1,2,4, J. Cloos1,3, G.J.L. Kaspers1, W.P. Vandertop2,4, B.A. Tannous5, D.P. Noske2,4, T.Wurdinger2,4,5
Depts of 1Pediatric Oncology/ Hematology, 2Neurosurgery and 3Hematology and 4Neuro-oncology Research Group,
5Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA. VU University
Stichting KIKA en NIH-R21
Specific tumor-targeting of iNKT cells and VγVδ2 T cells using nanobody technology
R. de Bruin, T.D. de Gruijl1, H. Verheul1, R.J. Scheper2, J.J. van der Vliet1
1Dept. Of Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam
KWF fellowship
Stereotactic ablative radiotherapy for lung cancer and comparative effectivess research
S. Senan, D.A. Palma2, W.F.A.R. Verbakel, F.J. Lagerwaard, C.J. Haasbeek, C.L. Ong, A.V. Louie, D. Rodrigues, N.E.
Verstegen, J.P. Cuijpers, A.V. Louie2, B.J. Slotman
Departments of Radiation Oncology, VU University Medical Center, Amsterdam and 2Department of Radiation Oncology,
London Regional Cancer Program, London, Ontario, Canada
Stereotactic ablative ratiotherapy (SABR) for oligometastases
M. Dahele, C.J.A. Haasbeek, W.F.A.R. Verbakel, D.A. Palma2, B.J. Slotman, S. Senan
Departments of Radiation Oncology, VU University Medical Center, Amsterdam, 2 1Department of Radiation Oncology,
London Regional Cancer Program, London, Ontario, Canada
Study on the interaction between angiogenesis inhibition and radiotherapy
Thijssen VLJL, Kleibeuker E, Castricum K, Senan S, Griffioen AW, Verheul HM, Slotman B
Depts. of 1Radiotherapy, VU University Medical Center, and 2Radiotherapy, VU University Medical Center
Target identification specific for leukemic stem cells of acute myeloid leukemia
H. Verhagen1, M. Terwijn1, A. Rutten1, B. Ylstra2, R. Menezes3, G. Ossenkoppele1, G.J. Schuurhuis1, L. Smit1
Department of Hematology1, Microarray Facility, department of Pathology2, Department of Biostatistics3, VU University
Targeted therapy of osteosarcoma
drs. J. Posthuma de Boer1, dr. M. N. Helder1, dr. V.W. van Beusechem2, prof. dr. G.J.L. Kaspers3. prof. dr. B.J. van
Royen1
1Department of Orthopaedic Surgery, VU University Medical Center, 2department of Medical Oncology, VU University
Medical Center and 3department of Pediatric Oncology/Haematology, VU University Medical Center. Supported by
Aarhus University Hospital, Denmark, Stichting VUmc fonds VONK and the department of Orthopaedic Surgery, VU
University Medical Centre, Amsterdam
The Strategic Regeneration Network
Targeted therapy selection-based on tumor tissue phosphoproteomic and kinase activity profiles in patients with
solid tumors
M. Labots, J. C. Van der Mijn, H. Dekker, K. Gotink, M. Voebel-de Jong, R. Ruijter, M. Neerincx, T. V. Pham, H. J. Van
Der Vliet, C. R. Jimenez, J. Van Der Hoeven, G. A. Meijer1, H. M. Verheul
Dept. of Medical Oncology VU University Medical Center Amsterdam, Dept. of Pathology VU University Medical Center
Amsterdam
Targeting galectin-1 for the diagnosis and treatment of cancer
R. Heusschen1, I. Schulkens1, A.W. Griffioen1, H.M. Verheul1, V.L.J.L. Thijssen1,2
Depts. of 1Medical Oncology, VU University Medical Center, and 2Radiotherapy, VU University Medical Center
KWF UM 2008-4101
99. Targeting resistance to radio-chemotherapy by inhibition of the PI3Kinase-Akt signaling pathway
R.S. Narayan1, C.A. Fedrigo2, L.J.A. Stalpers3, B. G. Baumert4, M.E. van Linde5, N.A.P. Franken3, J. van den Berg1, J.
Theys4, G.J. Peters5, B.J. Slotman1, T. Wurdinger6, P. Sminia1
Depts. 1Radiation Oncology, 5Medical Oncology,6 Neuro-Oncology Research Group, VU University Medical Center;
2Pontificia Universidade Catolica do Rio Grande do Sul; Dept. 3Radiation Oncology, Academic Medical Center,
Amsterdam; 4Dept. Radiation Oncology Maastricht Universitair Medisch Centrum
KWF 2010-4874
100. The role of epigenetics in the treatment of pediatric brain tumors
S.E. Mir1,5, M. Smits2,5, E. Hulleman1,2,5, T. Wurdinger2,5, D. Noske2,5, G.J.L. Kaspers1, B. Drukarch3, J. Cloos1,4
Depts of 1Pediatric Oncology/ Hematology, 2Neurosurgery, 3Anatomy and Neusosciences and 4Hematology, 5Neurooncology Research Group, VU University Medical Center, Amsterdam
Mozaiek, KWF fellowship
101. Thymidine protection of rapamycin cytotoxicity is mediated by increased p70/S6k phosphorylation and autophagy
I.V. Bijnsdorp, F.A.E. Kruyt, M. Fukushima, G.J. Peters
Department of Medical Oncology, VUmc, Amsterdam, Taiho Pharmaceuticals, Tokushima, Japan, Department of Medical
Oncology, UMCG, Groningen
Taiho Pharmaceuticals, Japan
102. TRAIL-induced pro- and anti-apoptotic kinase activation in Non small cell lung cancer cells
K. Azijli1,2, S. Yuvaraj2, M.P. Peppelenbosch3, T. Würdinger4,5, H. Dekker1, J. Joore3, E. van Dijk6, W.J. Quax7, G.J.
Peters1, S. de Jong2, F.A.E. Kruyt2
1. Department of Medical Oncology, VU University Medical Center, Amsterdam, 2. Department of Medical Oncology ,
University of Groningen, University Medical Center Groningen, 3. Department of Gastroenterology & Hepatology,
Erasmus MC, Rotterdam 4. Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric
Oncology/Hematology, VU University Medical Center, Amsterdam 5. Molecular Neurogenetics Unit, Department of
Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02113, USA 6. Pepscan Presto
BV, Lelystad 7. Department of Pharmaceutical Biology, University of Groningen
Top Institute Pharma T3-112
103. Treatment and survival of indolent and aggressive NHL patients; population based studies in the Netherlands
D.E. Issa, M. Wondergem, O. Visser, J.M. Zijlstra, S. Zweegman, P.C. Huijgens
Department of Hematology, VU University Medical Center
104. Vaccination in acute myeloid leukemia; towards a cure by innovative dendritic cell-based immunotherapeutic
strategies
Ruben J1, Van den Ancker W1, de Gruijl TD2, Bontkes HJ1, Westers TM1, Ossenkoppele GJ1, van de Loosdrecht AA1
1Dept of Hematology, 2Dept of Oncology, VU University Hospital Amsterdam
Program 5
Late effects of brain tumor therapy
1. Efficacy and toxicity of cerebral glioma treatment
I. Bosma1, M.J. Vos1, E. Sizoo1, M. de Groot1, T.J. Postma1, J.C. Reijneveld1,11, M.J.B. Taphoorn1,13, W.P.
Vandertop2,12, J.C. Baayen2, B.J. Slotman3, F. Lagerwaard3, J.Buter4 , M. Klein5, O.S. Hoekstra6, F. Barkhof7, E.
Sanchez7, P. van der Valk8, A.A.T.P. Brink8, M.A. Blankenstein9, J. Berkhof10, J.J. Heimans1
Department of 1Neurology, 2Neurosurgery, 3Radiotherapy, 4Medical Oncology, 5Medical Psychology, 6 Nuclear
medicine, 7Radiology, 8Pathology, 9Clinical Chemistry, and 10Clinical Epidemiology and Biostatistics, VU University
Medical Center, Department of 11Neurology and 12Neurosurgery, Academic Medical Center, Amsterdam, 12Department
of Neurology, MC ‘Haaglanden’, Den Haag
Late effects of tumor treatment
2. Pediatric acute lymphoblastic leukemia: quality of life and cost-effectiveness of treatment
R.R.L. van Litsenburg¹, E.M.M. Meijer-van den Bergh², J. Huisman³, P.M. Hoogerbrugge4, C. Verhaak², G.J.L. Kaspers¹,
R.J.B.J. Gemke¹
Department of ¹Pediatrics VU University Medical Center, ²medical psychology UMC Nijmegen, ³Medical Psychology, VU
University Medical Center and 4Pediatrics UMC Nijmegen.
AGIKO
Patient reported outcome in head and neck cancer
3. Health related quality of life in head and neck cancer patients: survival, response shift, and care
I.M. Oskam1, R.N.P.M. Rinkel1, P. Doornaert2, I.M. Verdonck-de Leeuw1, R. de Bree1, J.A. Langendijk3, N.K.
Aaronson4, C.R. Leemans1
1Departments of Otolaryngology/Head-Neck Surgery, VU University Medical Center, 2Radiotherapy, VU University
Medical Center, 3Radiotherapy, University Medical Center Groningen, 4Division of Psychosocial Research &
Epidemiology, The Netherlands Cancer Institute Amsterdam
4. OncoCompass: Development and pilot testing of a e-health management platform to optimise disease management
in cancer patients
Lubberding S, van Uden-Kraan CF, Leemans CR. de Bree R, Gerritsen WR, van Kalken C, Kraaijenhagen RA, Cuijpers P,
Dept Otolaryngology/Head-Neck Surgery, VU University Medical Center, VU University Medical Center, Amsterdam
NDDO Foundation and KWF
5. OncoQuest: touch screen computer based screening of health related quality of life and distress
I.M. Verdonck-de Leeuw1, C.R. Leemans1, R.N.P.M. Rinkel1, P. Doornaert2, R. de Bree1, C.R. Leemans1
1Departments of Otolaryngology/Head-Neck Surgery, VU University Medical Center, 2Radiotherapy, VU University
Medical Center
Fonds NutsOhra 0702-118
129
6.
Patient reported speech and swallowing outcome in head and neck cancer
R.N. Rinkel1, R. de Bree1, J.A. Langendijk2, C.R. Leemans1, I.M. Verdonck-de Leeuw1
1Dept Otolaryngology/Head-Neck Surgery, VU University Medical Center, 2Dept Radiotherapy, University Medical Center
Groningen, VU University Medical Center, Amsterdam
Psycho-Oncology / Palliative Care
7. Psychosocial aspects in head and neck cancer patients
I.M. Verdonck-de Leeuw1, A.M.H. Krebber1, P. Cuijpers2, G. Kleijn2, A. van Straten2, R. de Bree1, C.R. Leemans1
1,Depts. Otolaryngology/Head-Neck Surgery, VU University Medical Center and 12Clinical Psychology, VU University
ZonMw DO 80-82305-98-09001, ZonMw DM (600-82600-98-8043/300020012); ZonMw PZ 1151.0003, Fonds NutsOhra 080T045
Psychosocial aspects in head and neck cancer
8. Costeffectiveness of psychological intervention via the internet in head and neck cancer patients
Krebber AMH, Leemans CR, Cuijpers P, van Straten A, Smit F, de Bree R, Becker A, Smit E, Verdonck-de Leeuw IM
ZonMw DC 80-82305-98-09001
9. Internet-based treatment of low-grade glioma patients with depression and fatigue; randomized controlled trial
M.Klein1, J.C. Reijneveld2,3, I. Verdonck4,5, J.J. Heimans2, P. Cuijpers5
Departments of 1Medical Psychology, 2Neurology, VU University Medical Center, 3Neurology, Academic Medical Center,
4Head-Neck Surgery, VU University Medical Center, 5Clinical Psychology, VU University, Amsterdam
KWF (Alpe d'Huzes) 4615-4804
10. Stepped care to improve symptoms of anxiety and depression in cancer patients
Krebber AMH, Leemans CR, Cuijpers P, van Straten A, Smit F, de Bree R, Becker A, Smit E, Verdonck-de Leeuw IM
ZonMW 600-82600-98-8043/300
11. Structured life review using autobiographical retrieval practice in depressed palliative head and neck cancer
patients
Kleijn G. de Bree R. Leemans CR, Bohlmeijer E, Steunenberg B, Eeltink C, Slotman B, Becker A, Smit E, Cuijpers P,
ZonMw PZ 1151.0003
Voice, speech and swallowing in head and neck cancer
12. Prediction of radiation-induced swallowing dysfunction after curative (chemo) radiation for head and neck cancer
M.C.E.M. Christianen, I.M. Verdonck-de Leeuw, M. de Bruijn, R.N. Rinkel, C.R. Leemans, P. Doornaert, J.A. Langendijk
Dept. Otolarynogology'/Head-Neck Surgery, VU University Medical Center Amsterdam
KWF RUG 2008-3938
13. Efficacy of voice therapy in patients with voice problems after treatment for early glottic cancer
C.D.L. van Gogh1, I.M. Verdonck-de Leeuw1, R.N. Rinkel1, J.A. Langendijk2, P. Doornaert3, H.F. Mahieu1
Groningen, 3Dept Radiotherapy, VU University Medical Center, Amsterdam
KWF Dutch Cancer Society RUG2008-3983, Fonds NutsOhra 080T-043, Eureka 2614 GGN371, VAZ/CVZ Doelmatigheid
00143 00143
14. LARINX: a web-based self-help programme for laryngectomized patients during and after treatment
Cnossen IC, Leemans CR, Rinkel RN, de Bree R, Eeerensten SE, Langendijk JA, Doornaert P Verdonck-de Leeuw IM
Michel Keijzer Foundation
15. Objective speech assessment in head and neck cancer: acoustic-phonetic and feature analyses by a neural network
M. de Bruijn1, J.A. Langendijk2, C.R. Leemans1, R. de Bree1, I.M. Verdonck-de Leeuw1
Groningen
KWF Dutch Cancer Society RUG2008-3983, Fonds NutsOhra 080T-043, Eureka 2614 GGN371, VAZ/CVZ Doelmatigheid
00143 2008-3983
16. Prevention of speech, swallowing, and shoulder impairment after treatment for head and neck cancer
Cnossen IC, Leemans CR, Rinkel, RN, de Bree R, Eerenstein SE, Langendijk JA, Doornaert P, Verdonck-de Leeuw IM
Fonds NutsOhra 080T-043 080T-043
Other projects
17. A combined physical exercise and psychosocial training program to improve physical fitness in children with cancer
K.I. Braam1, E.M. van Dijk2, E. van Dulmen-den Broeder1, M.A. Veening1, M. Bierings3, J. van der Net3, J.H.M. Merks4,
M.A. Grootenhuis4 G. Sinnema3, M. Chinapaw5, T. Takken3, J. Huisman2, G.J.L. Kaspers1
1Pediatric Oncology/ Hematology, VU University Medical Center, and 2Dept of medical Psychology VU university
medical center; 3Wilhelmina Children’s Hospital, University Medical Center Utrecht; 4Academic Medical Centre,
Amsterdam; 5EMGO institute, VU University Medical Center
Alpe d’HuZes/KWF 2009-4305
18. Distress and quality of life of patients treated with autologous stem cell transplantation following high-dose
chemotherapy: Outcome of stepped care
A. Braamse1, B. van Meijel2, O. Visser3, P.C. Huijgens3, A. Boenink1, P. Cuijpers4, P. van Oppen1 , A.T.F. Beekman1, J.
Dekker1
1 Dept. of Psychiatry VU University Medical Center, 2 Research Group Mental Health Nursing, Inholland University, 3
Dept. of Hematology VU University
VU University Medical Center and Inholland University
19. Early recognition and optimal treatment of delirium in patients with advanced cancer
E.C.W. Neefjes1, M.J.D.L. van der Vorst1, A.T.F. Beekman2, H. Berkhof3, H.M.W. Verheul1
Depts. of 1Medical Oncology, 2Psychiatry and 3Biostatistics of the VU University Medical Center
ZonMw 1151.0011
130
20. Early-detection of quality of life problems in children with Retinoblastoma and their parents
A.G. La Rivière1, J. van Dijk2, J. Huisman2, A. Frankfoorder1, G. Buurmans-Kool1, M.I. Bosscha1, A. Kors3, E. van
Dulmen-den Broeder5, M.A. Grootenhuis4, A. Houffelaar5, I.M. Verdonck-de Leeuw5 and A.C. Moll1
Depts. of 1Ophthalmology, 2Pedriatic Psychology, 3Pediatric Oncology, 5ENT/Head and Neck, VU University Medical
Center, and 4Clinical Psychology, Free University, and Psychosocial Department, Pediatrics, University Hospital of
Amsterdam
NutsOhra, grant 0901-072
21. Enhancing quality of life in low-grade glioma patients by attacking fatigue through modafinil: a randomized
magnetoencephalography study
S. Driessen1, K. Hilverda1, L. Douw2, M. de Groot2, M.J.B. Taphoorn2,4, J.J. Heimans2, J.C. Reijneveld2,3, M. Klein1
Departments of 1Medical Psychology and 2Neurology, VU University Medical Center, Amsterdam, 3Department of
Neurology, Academic Medical Center, Amsterdam, 4Department of Neurology, MC ‘Haaglanden’, Den Haag
Fonds NutsOhra Zorgsubsidies
22. Glucocorticoid induced HPA axis suppression in childhood acute lymphoblastic leukaemia and lymphoma
M.S. Gordijn1, R.J.B.J. Gemke1, J. Rotteveel1, M.B. Bierings2, C. van den Bos3, G.J.L. Kaspers1
Depts. of 1Pediatrics and Pediatric Oncology/Hematology, VU University Medical Center, 2Pediatric Hematology,
Wilhelmina Children’s Hospital, University Medical
Center Utrecht, 3Pediatric Oncology/Hematology, Emma’s Children Hospital / Academic
Medical Center
Dutch Cancer Society, grant VU 2010-4859
23. Health-related quality of life in high-grade glioma patients and their partners in the end-of-life phase
E. Sizoo1, J.J. Heimans1, M. Klein2, T.J. Postma1, R. Grant6, W. Grisold7, C. Marosi 8,G. Stockhammer9, H.R.W.
Pasman3, L. Deliens3 J.C. Reijneveld1,4, M.J.B. Taphoorn1,5
Departments of 1Neurology, 2Medical Psychology, and 3EMGO+, VU University Medical Center, Amsterdam, 4Department
of Neurology, Academic Medical Centre, Amsterdam, 5Department of Neurology, Medical Centre ‘Haaglanden’, Den
Haag, 6Department of Neurology, Western General Hospital, University of Edinburgh, United Kingdom, 7Ludwig Bolzman
Institute for Neuro-Oncology, Kaiser Franz Josef Hospital, Vienna, 8Department of Internal Medicine, Medical Univeristy,
Vienna, and 9Department of Neurology, Neuro-Oncology Group, Medical University of Innsbruck, Austria
Jacobus Stichting
24. Hypothalamic-Pituitary-Adrenal axis function in survivors of childhood acute lymphoblastic leukemia and healthy
controls
M.S. Gordijn1, R.R.L. van Litsenburg1, RJ.B.J. Gemke1, M.B. Bierings2, C.J. Heijnen3, P.M. Hoogerbrugge4, P.M. van de
Ven5, G.J.L. Kaspers1
Depts. of 1Pediatrics and Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, 2Pediatric
Hematology/Oncology, Wilhelmina Children’s Hospital, University Medical Center Utrecht 3Laboratory
Psychoneuroimmunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, 4Pediatric HematoOncology, Radboud University Nijmegen Medical Center, 5Epidemiology and Biostatistics, VU University Medical Center,
Amsterdam
KWF VU 2010-4859
25. Maintaining health-related quality of life of caregivers of glioblastoma patients: a randomized, two-group,
controlled trial
J. Lenting1, J.J. Heimans2, T.J. Postma2, M.J.B. Taphoorn2,3 J.C. Reijneveld2,4, M. Klein1
Departments of 1Medical Psychology and 2Neurology, VU University Medical Center, 4Department of Neurology,
Academic Medical Center, Amsterdam, 3Department of Neurology, Medical Center ‘Haaglanden’, Den Haag
Tug McGraw Foundation / National Brain Tumor Foundation
26. Metoclopramide, Dexamethasone or Aprepitant for the prevention of delayed chemotherapy-induced nausea and
vomiting in moderately emetogenic non-AC-based chemotherapy: the MEDEA trial
M.J.D.L. van der Vorst1, J. Dekker2, H. Berkhof3, H.M.W. Verheul1
Depts. of 1Medical Oncology, 2 Psychiatry/Rehabilitation Medicine and 3Biostatistics of the VU University Medical Center
27. NET-QUBIC, quality of life and biomedical cohort study in head and neck cancer: a feasibility study
A. van Nieuwenhuizen, C.R. Leemans, L. Buffart, R. de Bree, I.M. Verdonck-de Leeuw
Depts. Otolaryngology/Head-Neck Surgery, VU University Medical Center and 12Clinical Psychology, VU University
28. Neurotoxicity of cancer treatment: Neurocognitive dysfunction and underlying mechanisms
I. Schuitema1,2, A.J.P. Veerman1, C. van den Bos3, L.M.J. de Sonneville2
1Pediatrics Oncology/Hematology, VU University Medical Center, Amsterdam; 2Dept. of Child and Adolescent Studies,
University of Leiden, Leiden; 3Dept. of Pediatrics, Division of Pediatric Hematology and Oncology, Amsterdam Medical
Center, Amsterdam
29. Preclinical, translational and clinical research including quality of life and late effect studies in pediatric oncology
G.J.L. Kaspers1, E. van Dulmen-den Broeder1, F. Abbink1, V. De Haas1,2, E.G. Hulleman1, W.A. Kors1, N.A. Oeij1, S.
Mostert1, D.G. van Vuurden1, M.A. Veening1, A.J.P. Veerman1, J. Cloos1
1Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam and 2Dutch Childhood Oncology Group, The
Hague, The Netherlands
30. Predictive factors for severe weight loss in head and neck cancer patients
J.A.E. Langius1, C.R. Leemans2, P. Doornaert3, H.M. Kruizenga1, I.M. Verdonck-de Leeuw2, J.A. Langendijk4, P.J.M.
Weijs1
Depts. of 1Nutrition and Dietetics, Internal Medicine; 2Otolaryngology/Head and Neck Surgery; 3Radiation Oncology, VU
University Medical Center, Amsterdam and 4Radiation Oncology, University Medical Center Groningen, University of
Groningen, The Netherlands
CCA CCA2011-1-02
31. Prevalence and biomarkers of pre-cachexia and cachexia in advanced cancer patients scheduled for treatment with
chemotherapy
S. Buskermolen, M.A.E. van Bokhorst-van der Schueren, J.A.E. Langius, H.M.W. Verheul
Dept. of Nutricion and Dietics and Medical Oncology, VU University Medical Center, Amsterdam
Fonds NutsOhra
32. Quality of life and neurocognitive functioning in meningioma patients
131
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34.
35.
36.
37.
38.
39.
40.
41.
132
D. van Nieuwenhuizen1, S.M. Peerdeman2, L.J.A. Stalpers5, W.P. Vandertop2,6, , M. Waagemans1,3, J.J. Heimans1, M.
Klein3, J.C. Reijneveld1,4
Department of 1Neurology, 2Neurosurgery, and 3Medical Psychology, VU University Medical Center, Amsterdam,
Department of 4Neurology, 5Radiotherapy, and 6Neurosurgery, Academic Medical Center, Amsterdam
Quality of life in patients treated with radiotherapy for head and neck cancers
P. Doornaert, M.R. Vergeer, Verdonck-de Leeuw IM, C.R. Leemans, B.J. Slotman
Dept of Radiation Oncology, Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam
Reproductive function, ovarian reserve, and risk of premature menopause in female childhood cancer survivors: a
nationwide study
A. Overbeek1, M.H. van den Berg1, C.B. Lambalk2, G.J.L. Kaspers1, F.E. van Leeuwen3, E. van Dulmen-den Broeder1
Depts. of 1Pediatric Oncology/Hematology and 2Obstetrics & Gynaecology, VU University Medical Center,
3Epidemiology, Netherlands Cancer Institute, Amsterdam
KWF / Kika Foundation 2006-3622
Risk factors for impairments of quality of life after colorectal cancer: a feasibility study
A.M.J. Braamse1, C.J.J. Mulder 2, B Penninx1, J.H. Smit1, S.T. van Turenhout2 , J. Dekker1,3
Depts. Of 1Psychiatry, 2 Gastroenterology and Hepatology, 3 Rehabilitation Medicine, VU University Medical Center
Screening and treatment of psychological distress in colorectal cancer with metastasized disease: the TES-trial
H. Bomhof- Roordink MSc 1, A. Beekman MD, PhD 1, A. Honig MD, PHD, 1 A. Hoogendoorn PhD, 1, M. van der Linden
PhD, 2,3, B. van Meijel, PhD 4 , C.J.J. Mulder MD, PhD 5, M. van Tulder PhD 6, M. van der Vorst, MD, 3, H. Verheul, MD,
PhD 3, J. Dekker 1
1. Dept Psychiatry 2 Dept Medical Psychology, 3 Dept Medical Oncology , 4 Mental Health Nursing, Inholland University
of Applied Sciences, 5 Dept Gastroenterology and Hepatology, 6 Health Sciences/HTA, VU/VUmc
Sleep, fatigue and quality of life in survivors of childhood acute lymphoblastic leukemia
M.S. Gordijn1, R.R.L. van Litsenburg1, RJ.B.J. Gemke1, J. Huisman2, M.B. Bierings3, P.M. Hoogerbrugge5, G.J.L.
Kaspers1
Depts. of 1Pediatrics and Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, 2 Medical
Psychology, VU University Medical Center, Amsterdam / Pediatric Psychology & Social Work, University Medical Center
Utrecht, 3Pediatric Hematology/Oncology, Wilhelmina Children’s Hospital, University Medical Center Utrecht,
4Pediatric Hemato-Oncology, Radboud University Nijmegen Medical Center
KWF VU 2010-4859
Supportive care needs in patients treated with autologous or allogeneic hematopoietic stem cell transplantation
A.M.J. Braamse1, O. Visser 2, B. van Meijel3, P.C. Huijgens2, A.T.F. Beekman1, J. Dekker1,4
Depts. Of 1Psychiatry, 2 Hematology, 4 Rehabilitation Medicine, VU University Medical Center, 3 Inholland University of
Applied Sciences, Amsterdam
The development, implementation and evaluation of the meaning-centered group psychotherapy 'Living
Meaningfully with Cancer' in the Netherlands
N. van der Spek, J. Vos, R. Tollenaar, P. Cuijpers, I.M. Verdonck-de Leeuw
Depts. Otolaryngology/Head-Neck Surgery, VU University Medical Center and 12Clinical Psychology, VU University
KWF
The effects of enteral and parenteral fish oil on outcome in lung cancer and Graft-vs-Host Disease patients
B.S. van der Meij1, J.A.E. Langius1, M. van der Bokhorst – de van der schueren1, P.A.M. van Leeuwen2
Depts. of 1Nutrition and Dietetics and 2Surgery, VU University Medical Center
Voice, speech, and swallowing outcome in head and neck cancer patients
I.M. Verdonck-de Leeuw1, M. de Bruijn1, I.M. Cnossen1, C.D.L. van Gogh1, R.N.P.M. Rinkel1, R. de Bree1, S.E.
Eerenstein1, J.A. Langendijk2, M. Christianen2, P. Doornaert3, C.R. Leemans1
1Dept Otolaryngology/Head-Neck Surgery, VU University Medical Center, 2Dept Radiotherapy, Univeristy Medical Center
Groningen, 3Dept Radiotherapy, VU University Medical Center, Amsterdam
8. International collaboration
8.
International collaboration
Investigator
Prominent associates
Ang CW
•
•
H.P. Endtz, ICDDR-B, Dhaka, Bangladesh
P.F. Teunis, Emory University, Atlanta, USA
Appelmelk BJ
•
•
G. Besra, School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
D. Umetsu, Harvard Medical School, Boston, USA
Bitter W
•
•
Piere Genevaux, Laboratoire de Microbiologie et Génétique Moléculaires, Université Paul
Sabatier, Toulouse, France
Riccardo Manganelli, University of Padua, Padua, Italy
Boers M
•
•
•
•
•
•
•
•
•
•
P. Tugwell, Prof G. Wells, University of Ottawa, Ottawa, Canada
P. Brooks, University of Brisbane, Brisbane, Australia
V. Strand, University of Stanford, Stanford, USA
J. Kirwan, University of Bristol, Bristol, UK
W. Maksymovich, University of Edmonton, Edmonton, Canada
J. Smolen, University of Vienna, Vienna, Austria
P. Wilkinson, University of Liverpool, Liverpool, UK
J. Blazenby, University of Bristol, Bristol, UK
R. Christensen, University of Copenhagen, Denmark
A. Lanas, University of Zaragoza, Zaragoza, Spain
Braakhuis BJM
•
P. Golusinsky, Poznan University of Medical Sciences, Poznan, Poland
de Gruijl TD
•
Bernie A Fox/Walter Urba, Providence Cancer Center, Earle A. Chiles Research Institute,
Portland, OR
de Winter JP
•
•
D. Schindler, University of Wuerzburg, Department of Human Genetics, Wuerzburg, Germany
J. Rouse, University of Dundee, MRC Protein Phosphorylation Unit, Dundee, Scotland, UK
den Otter W
•
D. Characiejus, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
Gibbs S
•
Sens-it-iv consortium (30 international partners – multiple publications), Multiple in Europe
(www.sensitiv.eu), Europe
Hoekstra, OS / Boellaard R
•
W.A. Weber, S. Stroobants, S. Shankar, Freiburg, Antwerp, NCI (De, Be, US)
Jansen, G
•
Y.G. Assaraf, Technion-Israel, Institute of Technology University, Haifa, Israel
Kaspers GJL
•
•
•
•
F. Njuguna, MTRH, Eldoret, Kenya
L. Dalla-Pozza & R. Howman-Giles, The Childeren’s Hospital at Westmead, Sydney, Australia
G. Escherich & G. Janka-Schaub, German COALL Group, Hamburg, Germany
A.D. Schimmer, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Canada
Kaspers GJL & Bokenkamp A.
•
B. Stoffel-Wagner, Bonn University Medical Center, Bonn, Germany
Kaspers GJL & Cloos J
•
•
•
U. Creutzig & D. Reinhardt, AML-BFM Group, Hannover, Germany
B.A. Tannous, Harvard Medical School, Boston, USA
Kaspers GJL & Veerman AJP
•
Pudjo H. Widjayanto & M.N. Sitaresmi, Dr. Sardjito General Hospital, UGM, Yogyakarta,
Indonesia
Kirtschig G
•
University of Nottingham, University of Schleswig Holstein, Lübeck. Multiple in Germany and
UK, Europe International trial on bullous pemphigoid; BLISTER Study/ The Bullous Pemphigoid
Steroids and Tetracyclines Study ISRCTN13704604, EudraCT 2007-006658-24, MREC N°
08/H1008/174
Lammertsma AA
•
J. Wolf & C. Kobe, University Hospital of Cologne, Center for Integrated Oncology Cologne
Bonn and Department for Nuclear Medicine and Int. Med, Cologne, Germany
Moll AC
•
D.H. Abramson, MSKCC, New York, USA
Peters GJ
•
•
•
•
•
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•
I. Fichtner, Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany
J.M. Padron, Instituto Canario de Investigación del Cáncer (ICIC), Tenerife, Spain
P.A. Zucali & Prof. Dr. A. Santoro, Humanitas Hospital, Milan, Italy
M. Fukushima, Taiho Pharmaceuticals, Tokoshima, Japan
Carmelo Tibaldi, University of Livorno, Livorno, Italy
G. Giaconne, National Cancer Institute (NCI), Bethesda, USA.
133
Investigator
•
•
•
•
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•
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•
N. Funel, University of Pisa, Pisa, Italy
R.A. Schwendener, University of Zürich, Zürich, Switserland
H Schott, University of Tubingen, Tubingen, Germany
J. Balzarini, Rega Instituut, Leuven, Belgium
O. Fodstadt, Radium Hospital, Oslo, Norway
S. Eriksson, Uppsala University, Uppsala, Sweden
C.M. Galmarini, PharmaMar, Madrid, Spain
M. Sandvold, Clavis Pharma ASA, Oslo, Norway
Filippo Minutolo, University of Pisa, Pisa, Italy
K. Ichida, Jikei University, Tokyo, Japan
Y. Mayur, Center for Drug Design and Discovery, SVERI’s College of Pharmacy, Pandharpur,
India
J. Hall, EORTC Translational Research Division, Brussels, Belgium
A. Hanauske, Eli Lilly & CO, European Head Quarters, Germany
A. Paradiso, National Cancer Institute, Bari, Italy
Peters GJ & Giovannetti E
•
R. Danesi, University of Pisa, Pisa, Italy
Rustemeyer T
•
•
Sens-it-iv consortium (30 international partners – 1 publication), Multiple in Europe
(www.sensitiv.eu), Europe
EU commission on Consumers’ Health, Multiple in Europe, EU commision in Brussels, Belgium
Savelkoul PHM
•
Roch Molecular Systems, Plesangton, USA
Senan S
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•
•
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•
•
•
•
•
•
•
•
•
•
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•
D. Palma, G. Rodrigues & A.V. Louie, London Regional Cancer Program, Ontario, Canada
T. Treasure, University College London, London, UK
J. Peto, London School of Hygiene and Tropical Medicine, London, UK
M. O’Brien, Royal Marsden Hospital, London, UK
K. O’Byrne, St. James’s Hospital an Trinity College Dublin, Dublin, Ireland
G.G. Hanna, Belfast City Hospital, Belfast, UK
M. Snee, St. James University Hospital, Leeds, UK
R. Muirhead, Beatson West of Scotland Cancer Centre, Glasgow, Scotland, UK
C. le Péchoux, Institut Gustave Roussy, Paris, France
J.P. van Meerbeeck, University of Ghent, Ghent, Belgium
W. de Neve, Ghent University Hospital, Ghent, Belgium
J. Vansteenkiste, University Hospital Gashuisberg, Respiratiory Oncology Unit, Leuven,
Belgium
C. le Péchoux, Institut Gustave Roussy, Paris, France
J.P. van Meerbeeck, Univerisity of Ghent, Ghent, Belgium
W. de Neve, Ghent University Hospital, Ghent, Belgium
J. Vansteenkiste, University Hospital Gasthuisber, Respiratory Oncology Unit, Leuven, Belgium
G. Scagliotti, University of Turin, San Luigi Hospital, Turin, Italy
F. Cardenal, Institut Catala d’Oncologia, Medical Oncology, Barcelona, Spain
C. Faivre- Finn, The Christie, Manchester, UK
Senan S & Sminia P
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C.A. Fedrigo, Catholic University Rio Grande do Sul, Porte Alegro, Rio Grande do Sul, Brazil
Taphoorn MJB
•
•
M.J. van den Bent, on behalf of the EORTC Brain Tumor Group, EORTC Data Center, Brussels
Belgium
A. Bottomley, on behalf of the EORTC Quality of Life Department and PROBE project, EORTC
Data Center, Brussels Belgium
G. Cavaletti, Universita di Milano Biocca, Monza, Italy
van de Vliet H
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M. Bonneville, University of Nantes, Nantes, France
M. Exley, Harvard Medical School, Boston, USA
S. Porcelli, Albert Einstein College of Medicine, New York, USA
•
Steering committee of IGAS, International Genomewide Association Studies (Australië, VS,
China)
ASAS (Assessment of SpondyloArthritis International Society, worldwide)
Progenika (Madrid)
R. Plenge (VS)
•
•
•
•
van der Sar AM
•
G.S. Besra & Dr. A. Bhatt, School of Biosciences, College of Life and Environmental Sciences,
University of Birmingham, Edgbaston, United Kingdom
van der Waal I
•
R.A. Mendes & J.F.C. Carvalho, Faculty of Dental Medicine, Department of Oral Surgery,
University of Porto, Porto, Portugal
K. Nylander, University of Umeã, Department of Odontology/Endodontics Medical Biosciences,
Umeã, Sweden
C. Scully, University College London, London, UK
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•
134
Investigator
van Furth AM
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J. Schoeman, Tijgerberg Hospital, Cape Town, South-Africa
C.J. Reinecke, Centre for Human Metalbolomics, Potchefstroom, South-Africa
R. Peters, ANOVA Health Institute, Limpopo, South-Africa
J. Bartlett, John Hopkins University, Baltimore, USA
T. Msoka, Kilamanjaro Christian Medical Centre, Moshi, South-Africa
van Furth AM & van der Kuip M
•
D. Kirschner, Department of Microbiology and Immunology, Uiversity of Michigan, Ann Arbor,
Michigan, USA
van Rossum LGM
•
J. Duffy, St. Vincent’s University Hospital, Department of Pathology and Laboratory Medicine/
UCD School of Medicine and Medical Science, Dublin, Ireland
van Schaardenburg D
•
Validation of new ACR/EULAR criteria for remission of rheumatoid arthritis: VUmc, Reade,
Vienna, Ottawa, Nijmegen. See publication van Tuyl 2011 in the early arthritis section.
Further studies on the prognostic significance of fulfilling these criteria are underway
Verheul H
•
•
M. Carducci, John Hopkins University, Baltimore, USA
R.P. Pili, Rosswell Park Cancer Institute, Buffalo, USA
Waisfisz Q / Meijers-Heijboer H
•
Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA): broad international collaboration
Windhorst AD
•
A.J. Airaksinen & T. Meski, University of Helsinki, Finland
Wurdinger T
•
Bakhos Tannous, Massachusetts General Hospital/Harvard Medical School, Boston, USA
Zijlstra JM
•
A. Engert, German Hodgkin Study Group, Cologne, Germany
Zweegman S
•
Y.G. Assaraf, The Fred Wyszkowski Cancer Research Laboratory, Department of Biology,
Technion-Israel Institute of Technology, Haifa, Israel
A.D. Schimmer, Ontario Cancer Institute, Princess Margaret Hospital Toronto, Toronto, Canada
•
135
136
9. Scientific Research Committee
9.
Scientific Research Committee
CWO: Clinical protocols
Indiener
Titel
S. Sie
Effect of procalcitonin-guided decision making on duration of antibiotic therapy in suspected
early –onset neonatal sepsis: multicenter prospective randomized intervention study.
A.A. van Bodegraven
A long-term assessment of safety and efficacy of AMG 827 treatment in subjects with crohns
disease
M.H.A Jansen
89
E. Clasquin
Exploring alternative wound care treatment for percutaneous gastrostomy site infection: a
prospective, randomized, open blinded end-point (PROBE) design
A.E. Voskuyl
A multicenter, prospective cohort study ushing Nailfold Videocapillaroscopy (NVC) and other
factors to determine the risk of developing Digital Ulceration in patients with Systemic Sclerosis
(SSc)
H.M.W. Verheul
A phase II Randomized, Open-Label, multicenter Study Comparing CO-1.01 WithGemcitabine as
First-Line Therapy in Patients with Metastatic Pancreatic Adenocarcinoma
M.E.D. Chamuleau
A phase Ib, multicenter, open-label study of HCD122 administered intravenously in combination
with bendamustine in patients with CD40+ follicular lymphoma who are refractory to rituximab.
Protocol CHCD122A22104
Zirconium-bevacizumab uptake in patients with diffuse intrinsic pontine glioma imaged by PET
M.Labots
Biological Response evaluation of kinase inhibitors in advanced solid malignancies
A.J.M. van den Eertweg
An open Phase I study of immunization with the recNY-ESO-1 + AS15 Antigen-Specific Cancer
Immunotherapeutic in patients with NY-ESO-1- positive unresectable an progressive metastatic
cutaneous melanoma
S. Gisbertz
Closure of the pancreatic Remnant after distal pancreatectomy; a prospective randomized
controlled trial (CPRtrial)
D.A. van Dam
SIMPEL- trial (Single Incision, Miniport or convEbtional Laparoscopic surgery for uncomplicated
symptomatic cholecystolithiasis)
J.M.A. Daniels
TEXACOLD. Is antibiotic treatment associated with reduced risk of subsequent exacerbation and
mortality in chronic obstructive lung disease?
H.M.W. Verheul
Open-Label Multicenter 2-Arm Phase I study of RO5429083 with Dose-Escalation and Extension
Cohort, and Imaging Cohort with RO5429083 and 89Zr-labeled RO5429083, in Patients with
Metastatic and /or Locally Advanced, CD44-Expressing, malignant Solid Tumors.
S. Zweegman
HOVON 95 MM: A randomized phase III study to compare Bortezomib, Melphalan, Prednisone
(VMP) with High Dose Melphalan followed by Bortezomib, Lenalidomide, Dexamethasone (VRD)
consolidation and Lenalidomide maintenance in patients with newly diagnosed multiple
myeloma.
M.J. Wondergem
TAMIL study: treatment induced alterations in microenvironment in follicular lymphoma. A
multicenter descriptive study.
H. Kabboue
Atopic dermatitis and vitamin D
J.C. Reijneveld
Cognitive function and health related quality of life of long-term anaplastic oliogodendroglioma
and oligoastrocytoma survivors from EORTC study 26951
R. de Bree
PET-CT lymphoscintigraphy for sentinel node detection in head and neck cancer: a feasiblility
study
E. Boven
Nature and mechanism of cognitive deficits following chemotherapy: an (f)MRI study
A. Voskuyl
Éffects of bosentan in a HOMogenEous population of SSc subjects with a predefined restriction of
blood flow in the hands (HOME)
H.J. Bonjer
Perioperative selective decontamination of the digestive tract (SDD) in elective colorectal cander
patients: a multicenter randomized clinical trial
J.C. Reijneveld
Phase III intergroup Study of Radiotherapy versus Temozolomide Alone versus radiotherapy with
concomitant an adjuvant Temozolomide for Patients with 1p/19q Codeleted Anaplastic Glioma
D.M. Ferns
Charting of immune reactivity agains HPV in patients with HPV-induced (pre)malignant lesions
(The CIRCLE study 2)
H. Dekker
Peri-implantitis, implant loss and osteoradionecrosis in oral cancer patients
H.M.W. Verheul
Pilot study on the determination of intratumoral concentractions of kinase inhibitors in patients
with advanced solid malignancies
A.J.M. van den
Eeertwegh
An open-label, multicenter expanded access study of RO5185426 in patients with metastatic
melanoma
S.F. Bakker
Concomitant presence of Coeliac disease in adult patients with type 1 diabetes mellitus;
enhancement (micro) vascular risk?
137
Indiener
Titel
A.J.M. van den Eertwegh
An open-label, randomized, multi-center, Phase III study to compare the satety and efficacy of
TKI258 versus sorafenib in patients with metastatic renal cell carcinoma after failure of antiangiogenic (VEGF-targeted and mTOR inhibitor therapies)
E.F. Smit
Phase III, randomized, open-label study of the efficacy and safety of crizotinib versus
pemetrexed/cisplatin or pemetrexed/carboplatin in previously untreated patients with nonsquaumous carcinoma of the lung harboring a translocation or inversion event involving the
anaplastic lymphoma (ALK) gene locus
S. Gisbertz
Acute CHOlecystitis in high risk patients: percutaneous ChOlecystostomy versus LAparoscopic
cholecys TEctomy (CHOCOLATE trail)
E.M. de Boer
A double blind, comparative, superiority, multi center investigation evaluating the efficacy of an
absorbent foam dressing containing silver (Mepilex AG) versus the same dressing without dressing
used on subjects with venous leg ulcers or mixed ulcers – PUMA 416
S. Gibbs
A phase 2 randomized controlled comparative efficacy and safety study of Tiscover and Remaix
in chronic (arterio-)venous ulcers which is registered under A-SKIN_TIS2010
J.M.A. Daniels
The ProFECT trial: Detection and treatment of endobronichial (pre-)malignant lesions with
autofluorescence bronchoscopy after treatment of early stage lung cancer in COPD patients
G.J. Ossenkoppele
A phase II/III randomized, open-label study to compare the efficacy and safety of intravenous
volasertib in combination with subcutaneous cytarabine versus investigators choice of antileukemic treatment in adult patients with relapsed of refractory acute myeloid leukemia with no
established treatment options (POLO – AML1)
S. Zweegman
Onyx PX-171-009: A randomized, Multicenter, Phase 3 Study, comparing Carfilzomib,
lenalidomide and Dexamethasone (CRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects
with Relapsed Multiple Myeloma
S.M. Franken
Psoriasis and daily low emission phototherapy; effects on disease and vitamin D level
J. van der Laken
Multicenter study with a 16-week double-blind placebo-controlled (during the initial 2 weeks)
randomized period, followed by a 24-week open-label extension to assess magnetic resonance
image-verified early response to ceertoluzimab pegol in subjects with active rheumatoid arthritis
H. Trum
Diagnostische lparaoscopie ter predictie van de uitkomst van cytoreductieve chirurgie bij
patiënten met vergevorderd stadium ovariumcarcinoom (LapOvCa)
V. de Haas
.
Euronet-PHL-C1: First international Inter-Group Study for classical Hodgkins Lymphoma in
Children and Adolescents
E. Smit
A phase 3, randomized, double-blinded, placebo-controlled study of ARQ 197 plus Erlotinib
versus placebo plus Erlotinib in previously treated subjects with locally advanced or metastatic,
non-squaumous, non small cell lung cancer
E. Boven
Randomized, Open-Label Study of Abiraterone Acetate (JNJ-212082) Plus Prednisone With of
Without Exemestane in Postmenopausal Women with ER+ Metastatic Breast Cancer Progressing
After Letrozole or Anastrozole Therapy
W.R. Gerritsen
A Multinational Phase 3, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study
of Oral MDV 3100 in Chemotherapy-Naïve Patients with Progressive Metastatic Prostate Cancer
Who Have Failed Androgen Deprivation Therapy
A.A. van Bodegraven
A phase 2b randomized, placebo-controlled study to evaluate the clinical efficacy and safety of
induction and maintenance therapy with BMS-936557 in subjects with active ulceratie colitis
M. van Bokhorst / H.
Verheul
Prevalence and biomarkers of pre-cachexia and cachexia in advanced cancer patients scheduled
for treatment with chemotherapy
E. Boven
Protein profiling in breast cancer to identify biomarkers
H. Verheul
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo Controlled, Trial of AMG 479 or
Placebo in Combination with Gencitabine as First-line Therapy for Metastatic Adenocarcinoma of
the Pancreas
H. Verheul
A randomized multicenter clinical trial for patients with multi-organ, colorectal cancer
metastases comparing the combination of chemotherapy and maximal tumor debulking versus
chemotherapy alone
M.E. van Linde / H.
Verheul
A randomized phase II clinical trial on axitinib for the treatment of patients with recurrent
glioblastoma
H. Verheul / v.d. Vorst
Metoclopramide, Dezamthasome or Aprepitant for the prevention of delayed chemotherapyinduced nausea and vomiting in moderately emetogenic non-AC-based chemotherapy: the MEDEA
trial
W.P. Vandertop
MOBI-KIDS protocol; Study on communication technology, environment and brain tumours in
young people
E.F. Smit
An open-label, multicenter, randomized, phase 2 study evaluating the safety and efficacy of
cisplatin and pemtrexed with of without cixutumumab as first-line therapy in patients with
advanced nonsquamous non-small cell lung carcinoma
G.J.L. Kaspers
DREAMS II Study; HPA axis function and sympathetic nervous system activity in survivors of
childhood acute lymphoblastic leukemia
138
Indiener
Titel
S. Zweegman
Revlimid, Endoxan, Prednisone Evaluation After prior revlimid Treatment (REPEAT): A phase 1
and phase 2 study of lenalidomide (Revlimid) in combination with cyclofphosphamide (endoxan)
and prednisone (REP) in relapsed/refractory multiple myeloma.
J.J.W.M. Janssen
HOVON 108 MM: A randomized phase II study for the evaluation of T cell depleted nonmyeloablative allogeneic stem cell transplantation followed by early consolidation with
lenalidomide or lenalidomide combined with bortezomib and subsequent DLI for patients with
multiple myeloma in progression of relapse following first line therapy.
M.E. van Linde / H.
Verheul
An open-label, Phase I/IIa, dose escalating study of 2B3-101 in patients with solid tumors and
brain metastases
A.E. Voskuyl
A phase 3, randomised, double-blind, placebo-controlled, multicenter study of the efficacy and
safety of four 12-week treatment cycles (48 weeks total) of epratuzumab in systemic lupus
erythematosus subjects with moderate to severe disease (embody 2)
A.A. van Bodegraven
Assessment of the performance of the new generation Pillcam colon capsule (PVVE2) in Crohns
disease: an exploratory study.
G.J.L. Kaspers
Whole-body MRi voor initiële stagering, vroege respons bepaling en restagering na behandeling
bij kinderen met Hodgkin lymfoom (add-on study)
G.J.L. Kaspers
Efficacy of Carboplatin Administered Concomitantly With Radiation and 13-Cis Retinoic Acid as a
Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma / PNET Patients- a Groupwise
Phase III study
G.J.L. Kaspers
Chronic Disease in Immune Thrombocytopenia of Childhood (Chronic ITP in the Netherlands in
KIDs, the CIN-KID study)
L. de Castilho
Bielschowsky
Tumor derived vesicles as biomarkers for ovarian cancer
M.L. Seinen
Hepatic histology of IBD patients following one year of combination therapy with allopurinol and
low-dose conventional thiopurines
A.A. van de Loosdrecht
TRC114968, A Three-part Study of Eltrombopag in Thrombocytopenic Subjects with
Myelodysplastic Syndromes of Acute Myeloid Leukemia (Part 1: open-label, part 2: randomized,
double blind, part 3: extension). Short title: ASPIRE
E.F. Smit
A Phase II open label, multicenter randomized study to access the efficacy and safety of GSK
1120212 compared with docetaxel in 2nd line subjects with targeted mutations (KRAS, NRAS,
BRAF, MEKI) in locally advanced or metastatic non-small cell lung cancer (NSCLC stageIIIbwet-IV)
J.G. Hugtenburg
Validation of dried blood spot sampling in therapeutic drug monitoring of nilotinib
M.E.D. Chamuleau
HOVON 109 CLL: Efficacy and safety of first-line therapy with chlorambucil, rituximab and
lenalidomide (Revlimid®)(CR2) in elderly patients and young frail patients with advanced Chronic
Lymphocytic Leukemia (CLL): a phase I/II trial
G.G. Kenter
Tolerance and immunogenicity of ProCervix, a therapeutic vaccine composed of 2 Human
Papillomavirus (HPV)antigens vectored in recombinant adenylate cyclises, in HPV 16 and/or HPV
18 infected women with normal cytology
G. Pals
Genetic sequencing study in Primary Ciliary Dyskinesia
H.M.W. Verheul
Prediction of response to kinase inhibitors based on protein phosphorylation profiles in tumor
issue from advanced renal cell cancer patients
C.M.J. van Nieuwkerk
A phase 4, Randomized, Open-Label, Active-Controlled, Superiority Study to Evaluate the
Efficacy and Safety of Tenofovir Disoproxil Fumarate (TDF) in Combination with Peginterferon
alfa-2a (Pegasys) versus Standard of Care Tenofovir Disoproxil Fumarate Monotherapy of
Peginterferon alfa-2a Monotherapy for 48 weeks in Non-Cirrhotic Subjects with HBeAg-Positive or
HBe-Negative Chronic Hepatitis B (CHB)
M.E.D. Chamuleau
HOVON 110 FL/ReBeL study: a randomized phase I/II trial of lenalidomide and rituximab with or
without bendamustine in patients ≥ 18 years with relapse follicular lymphoma, a HOVON/GLSG
study
J.C. Reijneveld
The effect of dexamethasone on the biodistribution of [3-N-11C-methyl] temozolomide in
glioblastoma multiforme patients; a pilot study
NB handtekening afdelingshoofd op signature sheet, (origineel volgt nog)
W. Mellema
A phase II study of sorafenib and metformin in patients with stage IV non-small cell lung cancer
(NSCLC) with a K-Ras mutation
NB brief met handtekening afdelingshoofd is onderweg.
Clinical evaluation of the underlying mechanisms of targeted therapy related toxicities
R.J.A. van Moorselaar
A phase 3 randomized, double-blind, placebo-controlled study of tasquinimod in men with
metastatic castrate-resistante prostate cancer
S. Zweegman
CC-4047-MM-003: A phase 3, Multicenter, Randomized, Open-label Study to compare the Efficacy
and Safety op Pomalidomide in Combination with Low-Dose Dexamehasone versus High-Dose
Dexamethasone in Subjects with Refractory or Relapsed and Refractory Multiple Myeloma
139
Indiener
Titel
S. Zweegman
CC-4047-MM-003/C: Open-label, multi-center, single-arm study for the safety and efficacy of
pomalidomide (CC-4047) monotherapy for subjects with refractory or relaps and refractory
multiple myeloma: a companion study for clinical trial CC-4047-MM-003 (
W. Mellema
Sorafenib pharmacokinetics in non small cell lung cancer patients: an in vivo study using positron
emission tomography
A.A. van Bodegraven
A phase 2a, randomized, double-blind, sponsor unblended, placebo-controlled, parallel, multiple
dose study to evaluate the pharmacodynamics, pharmacokinetics and safety of Anrukinzumab in
patients with active ulcerative colitis (#B2421003)
CA 184169 A Randomized Double-Blind Phase III Study of Ipilimumab Administered at 3 mg/kg vs
at 10 mg/kg in Subjects with Previously Treated or Untreated Unresectable of Metastactic
Melanoma
A. Becker
Anamorelin HCI in the Treatment of Non-Small Cell Lung Cander – Cachexia (NSCLC-C): A
randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase III Study to evaluate the
Safety and Efficacy of Anamorelin HCI in Patients with NSCLC studies 301 and 303 (ROMANA I and
III)
A. Voskuyl
ACR/EULAR endorsed study to develop classification and diagnostic criteria for primary systemic
vasculitis
G.J.L. Kaspers
EWING 2008
CWO: Research projects / grant proposals
Grant
Principal
investigator
Title
KWF
R. Nagel
Identification van biomarkers and additional drug targets for
improvement of cetuximab therapy for head and neck cancer patients
KWF
L.J.W. Bosch
Molecular stool-bases test for early detection and control of colorectal
cancer: a life without cancer
KWF
T.E. Buffart
Tumor MiR profiling to individualize systemic treatment for patients with
advanced colorectal cancer.
KWF
L.M. Buffart
Predictors of participation, compliance and success of rehabilitation and
supportive care programs
KWF
H.J. Broxterman
Lysosomal sequestration and autophagy: mechanisms of resistance to
receptor tyrosine kinase inhibitors
Industry
N. Makris
Towards targeted therapy: quantitative imaging with PET and long lived
isotopes
NWO middelgroot
A.M. van der Sar
Real time, high throughput, high content screening from cells to
zebrafish by a automated high-information microscopy reader
Instituutspromovendus
R.J.A. Fijneman
Structural chromosomal rearrangements in colorectal cancer
M. van Egmond
Identification of of tumor-derived proteins that modulate macrophage
effector functions
IMI
R. Boellaard
Quantitative imaging in cancer: connecting cellular processes with
therapy proposal acronym: QuIC-ConCePt
CCA
R. Fijneman
Development of an improved molecular test for population-wide
colorectal cancer screening.
AGIKO
M. Neerincx
Individualized treatment of patients with advanced colorectal cancer
based on miRNA profiling
AGIKO
J.C. van der Mijn
Untitled
EU / IMI
R. Boellaard
Quantitative Imaging in Cancer: Connecting Cellular Processes with
Therapy: Data and Image Analysis (WP4)
AGIKO
M. Jansen
Phase I/II, Open-Label, Single-Arm Trial of investigational products
erlotinib and everolimus, added to irinotecan and bevacizumab in
subjects with malignant pontine glioma with progressive disease
KWF
K.S. Versteeg
Optimilization of systemic treatment strategies in elderly patients with
140
Grant
Principal
investigator
Title
advanced solid malignancies
ERC
M. van Egmond
The human IgA Fc receptor FcαRI; a coming of age!
Beheer BV
S.T.G Bruijnen
Clinical applications of Positron Emission Tomography for inflammatory
rheumatic diseases
CCA
C. Oudejans
What the placenta can teach us about cancer
CCA
R. Brakenhoff
Targeted therapy of precancerous fields in head and neck mucosa
CCA
V. van Beusechem
Clinical evaluation of virotherapy for glioblastoma multiforme using an
infectivity-enhanced oncolytic adenovirus.
CCA
N. Krekel/
S. Meijer
Ultrasound-guided breast-sparing surgery to improve cosmetic outcomes
and quality of life
CCA
I. Bijnsdorp
To treat or not to treat: prostasome prostate cancer diagnostics
CCA
S. Wilting
Discovery of pseudogenes as novel regulators in (hrHPV-induced)
carcinogenesis
CCA
M. van Bokhorst
Nutritional intervention in patients with advanced or recurrent colorectal
cancer undergoing chemotherapy
CCA
J. de Winter
Targeted therapy of squamous cell carcinomas in Fanconi anemia patients
CCA
J. de Winter/
H. Meijers
Identification of tumour and germ line mutations in young patients with
rectal carcinoma and colon carcinoma
CCA
P. Sminia
Anti-angiogenesis efficacy of PI3Kinase-Akt/mTOR pathway inhibitors in
combination with irradiation and temozolomide in brain tumour therapy
CCA
T. de Gruijl
OK Vaccines (Operatie Kamer Vaccins)
CCA
L. te Velde
The Fanconi pathway and Mitomycin C sensitivity in HIPEC patients with
peritoneal metastases of colorectal carcinoma
CCA
R. Blankenstein
The importance of local, intra-prostatic concentrations of
dihydrotestosterone (DHT) in prostate cancer and benign prostatic
hyperplasia (BPH)
CCA
A. Braamse
Supportive care needs in patients undergoing autologous stem cell
transplantation for hematological malignancies: a qualitative study
CCA
M. van Egmond
Role of macrophages in therapeutic effect of antibody mediated
immunotherapy of haematological malignancies
CCA
J. den Haan
Antibody responses to tumour-specific glycosylation forms of MUC-1 and
their effect in colorectal cancer
CCA
R. Mebius
Expression of vitamin A converting enzymes in colon cancer stem cells
and the
consequences for cancer stem cell survival
CCA
J. Meijerink
Near-Infra Red immunophoto-detection in peritoneal metastases in
Colorectal and Gynaecological cancers
CCA
C. Verweij/
H. van der Vliet
Systemic immunomonitoring of host-related gene signatures during
combined everolimus/cyclophosphomide therapy in renal cell carcinoma
CCA
E. Giovannetti
New strategies for treatment of EGFR-TKI resistant non-small cell lung
cancer
CCA
E. Giovannetti
Unravelling and targeting key molecular determinants and pathways in
the biology of cancer stem cells using bioluminescent orthotopic tumors
from primary pancreatic cancer cells characterized for their genetic
signature in comparison with the originator tumors
CCA
R. Steenbergen
Towards the identification of proteins directly involved in HPV-induced
immortalization and assessment of their potential value as early
detection biomarker
141
Grant
Principal
investigator
Title
CCA
H. van der Vliet
Phase 1 study to evaluate the safety and efficacy of pamidronate for the
treatment of malignant ascites
CCA
A. Greijer
Fast screening and evaluation of novel therapeutics in oncology by using
the 3-D in vivo tumour model on the chorioallantoic membrane of the
embryonized chicken egg
CCA
A. Greijer
Reactivation of Epstein Barr virus: exploiting the cause of cancer as novel
therapeutic target for cancer
CCA
M. van Linde/H.
Verheul
A biological effective dose finding clinical trial of monotherapy
bevacizumab in recurrent GBM
CCA
M. van der Kuip
Granuloma formation in the zebrafish brain after inoculation with
mycobacteria
CCA
K. Versteeg/
H. Verheul
Optimalization of systemic treatment strategies in elderly patients with
advanced solid malignancies
CCA
J. Dorsman
Novel targets for treatment of retinoblastoma
CCA
T. Buffart/
H. Verheul
MiR based profiling of advanced colorectal cancer for individualized
treatment
CCA
H. Joenje/
J. Dorsman
Whole genome next-generation sequencing to uncover novel mechanisms
of multidrug resistance
CCA
S. Senan
Development and clinical validation of imaging algorithms to distinguish
fibrosis from local recurrences following stereotactic ablative
radiotherapy in stage I non-small cell lung cancer
CCA
A. Geldof
Prostate cancer chemotherapy response monitoring using Positron
Emission Tomography
CCA
N. van Grieken
Molecular profiling of gastric cancer for the prediction of response to
(neo)adjuvant chemoradiation.
CCA
D. Heideman
Demarcation of the ‘switch’ to chromosomal instability in lung
carcinogenesis
CCA
P. de Witt Hamer
Maximizing resective low-grade glioma surgery using connectivity
diagnostics
CCA
P. de Witt Hamer
Accurate delineation of peripheral glioma infiltration using advanced
neuro-imaging to improve glioma treatment
CCA
T. Würdinger
KRAS diagnostics using blood platelets of colorectal cancer patients
CCA
F. van den
Eertwegh
Development of 89Zr-labeled ipilimumab for PET-imaging: towards a
predictive tool for metastatic melanoma patients treated with
ipilimumab
CCA
T. Pham
Comprehensive network-based analysis of OMICS data to uncover cancer
mechanisms/signaling, novel drug targets and biomarkers for
personalized medicine
CCA
J. Janssen
Application of phosphoproteomics for patient-tailored medicine in acute
myeloid leukemia and colorectal carcinoma.
CCA
G. Jansen
Exploration of anti-leukemic and anti-inflammatory effects elicited by
myelomonocytic cell-targeted aminopeptidase inhibitors with an
esterase-sensitive motif
CCA
S. Senan
Treatment of stage I non-small cell lung cancer: designing information for
patient participation in decision making
CCA
S. Cillessen
Targeting of autophagy to improve sensitivity to apoptosis of diffuse large
B-cell lymphoma cells
R. Mebius
The influence of vitamin A metabolism on immune cell differentiation in
the gut
Kika
J. Dorsman
Genomics of Retinoblastoma
142
Grant
Principal
investigator
Title
KWF fellowship
S. Derks
Individualized biology-driven treatment for esophageal cancer
KWF fellowship
R. de Leeuw
Translation of genetic data to define predictors in treatment of prostate,
lung and colorectal cancer
VENI
R. Nagel
Characterization of novel therapeutic targets for lund and head-and-neck
cancer
VENI
N. Koning
Sentinels or agitators? Brain macrophages and their immune modulating
capacities via the C-type lectin mannose receptor
9.3. CWO-DEC: Animal related protocols
Title
H. Veninga/
J. den Haan
Het effect van antigen targeting naar verschillende types dendritische cellen en macrofagen
op vroege B cel responsen in aan- en afwezigheid van helper T cellen
M. Perdicchio
Tumor-expressed sialic acids dampen anti-tumor immune responses via dendritic cell
modulation.
Hetty Bontkes
Het verkrijgen van rattenweefsels t.b.v. medisch immunologisch diagnostische testen.
B. Braakhuis
Voorspellen van de chemoradiatie response van hoofd-halstumoren in een realistisch in vivo
model
G. Kraal
Effect van adjuvanspeptiden op de activering van cytotoxische CD8 T cellen en CD4 T helper
cellen
A. Greijer
Cytoytische virusactivatie-therapie voor behandeling van Epstein-Barr virus (EBV)
gerelateerde lymfomen en carcinomen
W. Dong
Evaluatie van de oncolytische potentie van een nieuw conditioneel replicerend adenovirus,
AdOT-091, in een humaan prostaat kanker model in naakte muizen
L. van der Steen/
M. van Egmond
In vivo migratie van humane FcαRI transgene neutrofielen naar humaan IgA antilichamen
gericht tegen muis collageen type XVII
J. Jacobs
Wat is de rol van testosteron bij de metastasering van prostaatkanker
G. van Dongen
Aanvullende biodistributie- en therapie studies met anti-HGF nanobodies
R. Scheper
Effectiviteit van microneedle array applicatie versus intradermale injectie voor vaccinatie.
V. Caretti
Development of diffuse pontine glioma (DIPG) mouse models
J. Garcia-Vallejo
Development of EAE in mSIGN-R1-/- mice
M. Ulrich
Evaluatie van debridement efficiëntie en mogelijke negatieve effecten van een debrilase
wondbedekking in een acuut wondmodel in het varken
B. Appelmelk
Mycobacteriële kapsel componenten als nieuwe vaccins voor tuberculose
I. Bijnsdorp
Het vergelijken van de prostaatkanker cellijnen PC3 en LNCaP in in vivo groei en
metastasering.
E. Stoop
Vaccin potentie van Mycobacterium marinum mutant in volwassen zebravissen.
J. Garcia Vallejo
Isolation of microglia from mouse brain
M. Bögels
Geeft antilichaamtherapie met een humaan IgG1 antilichaam, gericht tegen de humane
epitheliale groei factor receptor (hEGFR) in een muizenmodel met humane of
gehumaniseerde colon tumoren, bescherming tegen het ontstaan van levermetastases na
chirurgie.
J. den Haan
Practicum FACS and CFSE Proliferatie Assay (september 2011 en 2012)
R. Mebius
Bepaling vitamine A metabolisme en mucosale immuun systeem in BALB/c en C57BL/6
muizen
N. Koning
Perivasculaire macrofaag en mannose receptor in neuroinflammatie
M. van Hout
Het beschermend effect van IgA en/of FcαRI tegen Salmonella enterica infectie
A. Stavenuiter
Potentieel gunstige effecten van de selectieve Vitamine D analogen op peritoneale
veranderingen in een preklinisch dier model voor peritoneale dialyse
M.M.W. Ulrich
Evaluatie van verschillende formuleringen weefsellijm met PDGF als hechtmiddel voor
huidtransplantaten
143
Title
L. Smit
De identificatie van specifieke therapie targets tegen de leukemische stamcel in chronische
myeloide leukemie
S. Grewal
Rol van ontstekingsfactoren en bacteriële producten in de uitgroei van levermetastasen
G. van Dongen
Validation of a method for quantitative assessment of biodistribution of near-infrared
fluorescent probes in optical imaging
G. van Dongen
Therapiestudie met bispecifieke anti-tumor Nanobodies gericht tegen zowel EGFR als IGF-1R
H. Veninga
T. Lagerweij
Bepalen van targetexpressie en medicijndistributie in hersenstamtumoren met behulp van
89
Zr-gelabelde antilichamen
M. Beijer
Effect van vitamine A op de ontwikkeling en homeostase van dendritische cellen in de milt
S. Grewal
Effecten van selectieve darm decontaminatie (SDD) op de aanhechting van tumorcellen in de
lever
T. Lagerweij
Development of pancreatic ductal adenocarcinoma (PDAC) mouse models from primary
cultures as new tools for therapeutics discovery
S. van Rijn
Een in vivo screen voor tumor supressor-genen die zijn ontregeld in GBM
H. Veninga
op CD4 en CD8 T cellen
L. van der Steen
De rol van interacties van immunoglobulin A (IgA) met de IgA Fc receptor (Fc RI) op
neutrofielen in mucosale ontsteking van het darmstelsel
J. Koning
Zijn Nestin positieve mesenchymale cellen de voorlopers van lymfeklier stromale cellen?
W. Unger
Remmen van ongewenste T-cel responsen via modulatie van dendritische cellen
I. Hiemstra
Het effect van door microflora gestimuleerde Toll-like receptor 2 en Nod2 signalering op de
barrière functie van het epitheel en de differentiatie van immuuncellen in de dikke darm.
A. Stavenuiter
Potentieel gunstige effecten van de selectieve Vitamine D analogen op peritoneale
veranderingen in een preklinisch uremisch dier model voor peritoneale dialyse
L. Smit
Bevestigen van mulilineage engraftment en leukemia initiërende capaciteit van de door ons
geïdentificeerde leukemische en normale stamcellen door middel van aldehyde
dehydrogenase activiteit in acute myeloide leukemie
W. Dong
Evaluatie van de oncolytische potentie van een nieuw conditioneel replicerend adenovirus,
AdOT-091, in een humaan long kanker model in naakte muizen
144
10. Evening lectures
10. CCA/V-ICI evening lectures
January 18, 2011
Highlights program 3 (Disease profiling)and program 4 (Innovative therapy)
Host: Connie Jimenez
Irene van der Horst-Bruinsma: Clinical studies in Ankylosing Spondylitis
Bart Crusius: (Immuno)genetics and genomics of Ankylosing Spondylitis
February 15, 2011
Highlights program 1 (Oncogenesis) and program 2 (Immunopathogenesis)
Host: Peter Snijders
Mariska Bierkens: Chromosomal profiles of high-grade cervical intraepithelial neoplasia relate to duration of preceding
high-risk HPV infection
Ingeborg Ouwehand: Glycan-modifications of antigen to induce anti-tumor responses
March 15, 2011
Highlights program 3 (Disease profiling)and program 5 (Quality of life)
Host: Conny Jimenez
Saskia Vosslamber: Understanding the pharmacology of B cell depletion (rituximab) in rheumatoid arthritis: towards
personalized medicine
Martin Klein: Factors affecting quality of life in primary brain tumor patients
April 19, 2011
Highlights program 1 (Oncogenesis) and program 4 (Innovative therapy)
Host: Ruud Brakenhoff
Chantal Stoepker: SLX4, a coördinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype
Costa Bachas: Molecular changes between diagnosis and relapse and their association with outcome in pediatric AML:
implications for personalized medicine
May 17, 2011
Highlights program 3 (Disease profiling) and program 2 (Immunopathogenesis)
Host: Guus van Dongen
Harry Hendrikse/Alex Poot: Development and clinical evaluation of radiolabeled tyrosine kinase inhibitors to image with
positron emission tomography
Joke den Haan: Collaboration between splenic macrophages and dendritic cells for the activation of immune responses
June 21, 2011
Highlights program 1 (Oncogenesis) and program 5 (Quality of life)
Host: P. Snijders
Robert van Boerdonk: DNA copy number alterations in endobronchial squamous metaplastic lesions predict lung cancer
Mecheline van der Linden: Psychosocial screening of patients with breast cancer
September 20, 2011
Highlights program 2 (Immunopathogenesis) and program 4 (Innovative therapy)
Host: Y. van Kooyk
Wendy Unger: Notch signaling is essential for potent effector function of tumor-specific human CD8 T-cells
Jurjen Ruben: Apoptotic blebs from leukemic cells as a preferred source of tumor associated antigen for dendritic cellbased vaccines
October 18, 2011
Highlights program 1 (Oncogenesis) and program 5 (Quality of Life)
Host: J. de Winter
Rinus Voorham: It’s a flat world, after all. Characterisation of colorectal flat adenomas.
Raphaele van Litsenburg: Quality of life in children with acute lymphoblastic leukemia
November 15, 2011
Highlights program 3 (Disease profiling) and program 4 (Innovative therapy)
Host: Cor Verweij
Joyce Lübbers: Towards the biology and diagnosis of preclinical rheumatoid arthritis
Yoony Gent: PET imaging for early arthritis detection: preclinical and clinical approaches
December 13, 2011
Highlights program 2 (Immunopathogenesis) and program 5 (Quality of Life)
Host: Rob Beelen
Famke Schneiders: Invariant NKT cells in Cancer
Annemarie Braamse: Which factors predict health-related quality of life in patients treated with HSCT for hematological
malignancies?
145

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