Telstar Laboratory Freeze Dryers

Laboratory Division
Laboratory Freeze Dryers
/$%25$725<)5((=('5<(56
1 /\R4XHVW
Laboratory freeze dryer
/\R$OID
Laboratory freeze dryer
/\R%HWD
R + D freeze dryer
LyoQuest
Laboratory Freeze-dryer
LyoQuest
The best choice for R+D laboratories
Extremely compact while incorporating robust technical
features and outstanding control performances.
The Telstar LyoQuest benchtop freeze dryer has been
developed to meet the most demanding requirements of
a research freeze dryer.
Based on more than 40 years of experience, Telstar
introduces the LyoQuest as state of the art in
performance and process control. The unit was
specifically developed for basic research in
biotechnology and scientific institutes.
LyoQuest control panel screens
Outstanding features
? Extremely compact bench mounted table-top unit. Large
? LyoQuest Plus allows fully automatic or semiautomatic
capacities of condensation (6 kg/24 h) in the minimum
possible space.
work. Auto-start up and automatic switch off routines are
included.
? Two different process oriented control systems, both PLC
? Pressure control: manual control (for LyoQuest Series) or
based, adapts the unit to every requirement:
- Basic control for LyoQuest Series: allows automatic
pressure control and shelves temperature control.
automatic control of vacuum (for LyoQuest Plus Series)
for faster freeze drying and reproducible results.
? Side mounted vacuum and drain connections with
valves.
- Plus control for LyoQuest Plus Series: allows automatic
pressure control and shelves temperature
programming.
? Upright AISI 316L condenser with total capacity of 8 kg,
? Touch screen that displays system operation parameters
? Automatic defrosting function. Condenser design allows
and alarm messages. Descriptive and timely information
display and setting selection is provided.
? Monitoring software (LyoLogger) to connect unit to PC
available.
which permits freezing of the samples.
easy and quick cleaning and defrosting.
? Two choices of temperature: -55°C and -85°C.
? Wide range of accessories and options to accommodate
every freeze drying application.
Dimensions
(mm)
Code
61644
58201
61646
61647
61646
61647
61653
61654
61655
61656
61655
61656
480
575
425
Technical Data
Features
Model
LyoQuest -55 / 230 V 50Hz
LyoQuest -85 / 230 V 50 Hz
LyoQuest -55 / 230 V 60 Hz
LyoQuest -85 / 230 V 60 Hz
LyoQuest -55 / 208 V 60 Hz
LyoQuest -85 / 208 V 60 Hz
LyoQuest -55 Plus / 230 V 50Hz
LyoQuest -85 Plus / 230 V 50 Hz
LyoQuest -55 Plus / 230 V 60 Hz
LyoQuest -85 Plus / 230 V 60 Hz
LyoQuest -55 Plus / 208 V 60 Hz
LyoQuest -85 Plus / 208 V 60 Hz
LyoQuest
LyoQuest Plus
Units
LyoQuest -55
LyoQuest -85
Ice condenser capacity
kg
8 (5 kg/24h)
8 (6 kg/24h)
8 (5 kg/24h)
8 (6 kg/24h)
Final condenser temperature*
°C
<-55
<-85
<-55
<-85
-
1
2
1
2
Number of compressors
LyoQuest -55
LyoQuest -85
Base unit weight
kg
65
70
65
70
Total power
kW
1,1
1,4
1,1
1,4
*All temperatures are given for room temperature up to +21°C
Accessories (only available for LyoQuest Plus)
Standard Chamber (allows control of temperature from ambient temperature to +70°C)
Reference Accessories
Description
62302
Standard chamber
Cylindrical acrylic chamber with 3 heated shelves (for raw material and bulk)
61660
Standard chamber with 8
port manifold
Cylindrical acrylic chamber with 3 heated shelves (for raw material and bulk), and 8 port
manifold with valves (for flasks or wide-neck filter bottles with CN29/32 connection)
61659
Standard stoppering
chamber
Cylindrical acrylic chamber with 3 heated shelves, manual vial closing device
(for vials and serum)
58913
Standard stoppering
chamber with 8 port
manifold
Cylindrical acrylic chamber with 3 heated shelves (for vials and serum), manual vial
closing device and 8 port manifold with valves (for flasks or wide-neck filter bottles with
CN29/32 connection)
Large capacity chamber (allows control of temperature from ambient temperature to +70°C)
Reference Accessories
71280
71280 +
7904
Description
Large capacity chamber
Cylindrical acrylic chamber with 3 heated shelves (for raw material and bulk)
Large capacity stoppering
chamber
Cylindrical acrylic chamber with 3 heated shelves, manual vial closing device
(for vials and serum)
Accessories
(available for LyoQuest and LyoQuest Plus)
Manifolds
Reference Accessories
Description
75292
Standard unheated chamber
Cylindrical acrylic unheated chamber with 3 shelves
70205
8 port manifold
8 port manifold including 8 rubber three way valves (for flasks or wide-neck filter bottles
with connection CN29/32)
7917
40 port manifold
40 port manifold including 13 mm outer diameter tube manifold (for ampoules)
62332
Adaptor plate for manifolds
and large capacity chamber
Adaptor to place manifolds and large capacity chambers on the base unit
61683
Drip tray
Tray which protects the freeze-dryer from condensation
Accessories Technical Data
Accessory
STANDARD CHAMBER
Dimensions, standard unheated chamber
Dimensions, standard chamber
Dimensions, standard chamber with 8 port manifold
Dimensions, standard stoppering chamber
Dimensions, standard stoppering chamber with 8 port manifold
Tray dimensions
Distance between shelves
Total loading surface of the product trays
LARGE CAPACITY CHAMBER
Dimensions, large capacity chamber
Dimensions, large capacity stoppering chamber
Tray dimensions
Distance between shelves
Total loading surface of the product trays
MANIFOLD
Drying in round bottom flasks or wide-neck filter bottles
Drying in ampoules
Drip tray
Standard stoppering
chamber with 8 port
manifold
Standard chamber with
8 port manifold
Standard chamber
Units
LyoQuest
mm
mm
mm
mm
mm
mm
mm
2
cm
Ø215x300
Ø215x300
Ø490x300
Ø215x470
Ø490x470
Ø160
70
600
mm
mm
mm
mm
2
cm
Ø315x440
Ø315x640
Ø240
70
1350
units
units
mm
8/16
40/80
Ø730
Stoppering chamber
8 port manifold
40 port manifold
Large capacity
chamber
Large capacity
stoppering chamber
Drip tray
Av. Font i Sagué, 55
Parc Científic i Tecnològic Orbital 40
08227 Terrassa (Spain)
T +34 937 361 600
F +34 937 859 342
www.telstar-lifesciences.com
05 307 0111 I
Telstar reserves the right to improvements and specifications changes without notice.
Benisoda, 3
28042 Madrid (Spain)
T +34 913 717 525
F +34 917 477 530
LyoAlfa 10/15
Laboratory Freeze-dryer
LyoAlfa 10/15
Laboratory Freeze-dryer
The optimal solution for laboratories:
With more than 45 years of experience, Telstar
introduces the New LyoAlfa equipment, particularly
suitable for research departments requiring large
freeze-drying capacities.
This laboratory unit is especially suitable for the R&D
centres in industries, universities, hospitals and
scientific institutes. It has been designed according
the GLP principles in order to comply with the
strictest international standards.
This model incorporates unique and high level
control performances, as well as excellent technical
features.
LyoAlfa 10/15 control panel screens
Outstanding features
Compact console design with casters in order to make it
?
easy to install.
Pressure control: automatic control of vacuum for faster
?
freeze drying and reproducible results.
PLC controlled equipment: automatic pressure control
?
and shelves temperature programming.
Isolation valve between chamber and condenser, very
?
useful to test freeze-drying end point by controlling the
pressure raising in the chamber.
Touch screen that displays system operation parameters
?
and alarm messages. Very wide and useful information
and setting selection is provided.
Side mounted vacuum and drain connections with
?
valves.
Monitoring software LyoLogger to connect unit to PC:
?
standard unit including RS232 port.
Upright AISI 316L condenser with total capacity up to
?
22 kg.
Unit allows fully automatic or semiautomatic process.
?
Auto-start up and automatic switch off routines are
included.
Automatic defrosting function. Condenser design allows
?
easy and quick cleaning and defrosting.
Two choices of temperature: -55°C and -85°C.
?
Wide range of accessories and options to accommodate
?
to every freeze drying application.
Dimensions
(mm)
Code
37583
50224
37585
39204
Model
LyoAlfa Plus 10 -55
LyoAlfa Plus 10 -85
LyoAlfa Plus 15 -55
LyoAlfa Plus 15 -85
1010
765
705
Technical Data
LyoAlfa Plus 10
Features
LyoAlfa Plus 15
Units
LyoAlfa 10-55
LyoAlfa 10-85
LyoAlfa 15-55
LyoAlfa 15-85
Ice condenser capacity
kg
16,5
16,5
22
22
Final condenser temperature*
°C
-55
-85
-55
-85
-
1
2
1
2
Base unit weight
kg
170
200
190
220
Total power
kW
2,8
3,4
3,2
4,3
Number of compressors
*All temperatures are given for room temperature up to +21°C
Accessories
Ref.
Accessories
34019
+ 33506
Chamber with
isolation valve
34019
+ 34072
Stoppering chamber with
isolation valve
32893
12 port manifold
7917
66626
65117
40 port manifold
Adaptor plate
LyoLogger software
Description
CHAMBER
Acrylic cylinder chamber with 4 heated shelves (for raw material and bulk). It
includes an additional upper shelf in order to thermally balance the equipment.
It also includes isolation valve between chamber and condenser.
Acrylic cylinder chamber with 4 heated shelves and manual vial closing device
(for vials and serum). It includes an additional upper shelf in order to thermally
balance the equipment. It also includes isolation valve between chamber and
condenser.
MANIFOLD
12 horizontal port stackable manifold including 12 rubber valves (for flasks or
wide-neck filter bottles with connection CN29/32).
40 port manifold including 13 mm outer diameter tube manifold (for ampoules).
Adaptor to place manifolds on the base unit.
Software which allows connecting the equipment to a PC to monitor graphics
and record data.
Accessories Technical Data
ACCESSORY
UNITS
DIMENSIONS
Dimensions chamber with isolation valve
mm
Ø 400 x 480
Dimensions stoppering chamber with isolation valve
mm
Ø 400 x 645
Product tray dimensions
mm
Ø 300
Clearance between shelves
mm
70
Chamber
Total loading surface
cm
2
2825
Manifold
Drying in round bottom flasks or wide-neck filter bottles
units
12/24
Drying in ampoules
units
40/80
Chamber
Stoppering chamber
Stackable 12 port
manifold with adaptor plate
40 port manifold
LyoLogger software
screen
Av. Font i Sagué, 55
Parc Científic i
Tecnològic Orbital 40
08227 Terrassa (Spain)
T +34 937 361 600
F +34 937 861 380
www.telstar-lifesciences.com
03 310 0111 I
Telstar reserves the right to improvements and specifications changes without notice.
Benisoda, 3
28042 Madrid (Spain)
T +34 913 717 525
F +34 917 477 530
/\R%HWD
5')UHH]H'U\HUV
'HVLJQIHDWXUHV
7KH /\R%HWD LV D FRPSDFW XQLW ZLWK FDVWRUV FRQVWUXFWHG LQ D VWHHO VWRYHHQDPHOOHG FDELQHW 7KH HTXLSPHQW LV
VXSSOLHG IXOO\ DVVHPEOHG LQFOXGLQJ WKH YDFXXP DQG UHIULJHUDWLQJ V\VWHP DQG DOO QHFHVVDU\ HOHPHQWV UHDG\ IRU
RSHUDWLRQDIWHUFRQQHFWLQJWRWKHXWLOLW\VHUYLFHV
(IILFLHQW'HVLJQ
7+( '(6,*1 2) 7+,6 81,7 2))(56 7+( %(67
&$3$%,/,7,(6 )25 5' $&7,9,7,(6 /\R%HWD KDV
EHHQ HTXLSSHG ZLWK WKH DSSURSULDWH FRPSRQHQWV
GHYLFHVDQGVHQVRUVWRFRQWUROSURFHVVLQJFRQGLWLRQV
WHPSHUDWXUHSUHVVXUHDQGWLPH7KLVDOORZVGHILQLQJ
WKH SURFHVV YDULDEOHV WR DFKLHYH DGHTXDWH FRQWURO
DQGUHSURGXFLELOLW\
7KHHTXLSPHQWLQFOXGHVEUD]HGSODWHKHDWH[FKDQJHUV
WKDW XVHG LQ FRPELQDWLRQ ZLWK RWKHU KLJK TXDOLW\
FRPSRQHQWV <,(/'6 &22/,1* $1' +($7,1*
5$7(62)ƒ&0,1WKHVDPHDVSURGXFWLRQIUHH]H
GU\HUV
237,0,=$7,212)352&(665(&,3(6,6($6,/<
3(5)250(' %< 0($16 2) 7+( &+$0%(5
&21'(16(59$/9(ZKLFKDOORZVIRUSUHVVXUHULVH
WHVWLQJ DQG WKHUPRG\QDPLF FRQWURO 7KLV YDOYH DOVR
SHUPLWV SURFHHGLQJ ZLWK WKH SURGXFW ORDGLQJ DQG
XQORDGLQJZLWKRXWGHIURVWLQJWKHFRQGHQVHULILWKDV
QRWUHDFKHGIXOOFDSDFLW\
7KHUHIULJHUDWLRQV\VWHPLVFDSDEOHRIUHDFKLQJƒ&
LQ WKH FRQGHQVHU DQG ƒ& RQ WKH VKHOYHV ,W RQO\
XVHV+)&JDVHVZKLFKDUHDXWKRUL]HGIRUXVHERWK
DWWKHSUHVHQWDQGLQWKHORQJWHUP
)OH[LELOLW\RI8VH
%\XVLQJWKHVWRSSHULQJGHYLFHWKHGLVWDQFHEHWZHHQ
WKH VKHOYHV FDQ HDVLO\ EH PRGLILHG VR 7+( 81,7
&$1 %( $'$37(' 72 ',))(5(17 352'8&7
),//92/80(69,$/6,=(6$1'259,$/7<3(6
0RUHRYHUDODWHUDOLQOHWSRUWDOORZVWKHFRQQHFWLRQ
RIDWKUHHZD\YDOYHPDQLIROGIRUWKHIUHH]HGU\LQJRI
&1RSHQIODVNV
7KHEHVW6ROXWLRQV
IRU$GYDQFHG5HVHDUFK
&HQWHU
+LJK4XDOLW\DQG6XSHULRU&UDIWVPDQVKLS
7+( &+$0%(5 $1' 6+(/9(6 +$9( %((1 &216758&7('
:,7+7+(6$0(3+,/2623+<$6352'8&7,2181,767KH\
DUHPDGHHQWLUHO\IURPVWDLQOHVVVWHHO$,6,/DQGWKH\DUHIXOO\
DFFHVVLEOHLQVLGHIRUFOHDQLQJSXUSRVHV7KHFRQGHQVHUZKLFKLV
DOVRPDGHRI$,6,/KDVDUDSLGLFHGHIURVWLQJGHYLFHZKLFK
ZRUNVE\PHDQVRIDJURXSRIH[WHUQDOHOHFWULFDOUHVLVWRUV%RWK
WKHFKDPEHUDQGWKHFRQGHQVHUKDYHWUDQVSDUHQWDFU\OLFGRRUVWR
IDFLOLWDWHYLHZLQJRIWKHSURFHVV
'5<,1*&+$0%(5
3UHFLVH&RQWURODQG7HPSHUDWXUH8QLIRUPLW\
7KH WKHUPDO IOXLG FLUFXODWHV LQVLGH WKH VDQGZLFK W\SH FKDQQHOV
RIWKHVKHOYHV7KLVDOORZVSURGXFWSUHIUHH]LQJDQGODWHUKHDWLQJ
GXULQJVXEOLPDWLRQSKDVH$QDGGLWLRQDOVKHOIWKHUPDOO\EDODQFHV
WKH HTXLSPHQW 7+,6 )($785( )25 /$%25$725< )5((=(
'5<(56 *8$5$17((6 81,)250 +($7 75$16)(5 $7 $//
7+(6+(/9(6
5HVHDUFKO\RSKLOL]HUVRIWHQKDYHWKHSUHVVXUHVHQVRUVORFDWHGRQ
WKHYDFXXPOLQHUHIOHFWLQJWKHSUHVVXUHRIWKHOLQHWRWKHYDFXXP
SXPSUDWKHUWKDQLQWKHFKDPEHU7KH/\R%HWDKDVWKHYDFXXP
VHQVRU LQ WKH FKDPEHU ZKLFK PDNHV SRVVLEOH PRQLWRULQJ DQG
FRQWUROWKHSUHVVXUHZKLFKFRPSULVHVWKHHQYLURQPHQWZKHUHWKH
SURGXFWLVH[SRVHG7+,6$//2:6678'<,1*$1'2%7$,1,1*
7+(),1(676&$/(835(68/76
/\R%HWDVHULHV
$5HVSRQVLEOH&KRLFH
1HZGHPDQGVLQ5'FHQWHUVDUHUHODWHGWRVFDOHXS
IHDVLELOLW\ DQG TXDOLW\ RI SURFHGXUHV DQG UHVHDUFK
PHWKRGV)'$LQYHVWLJDWRUVFRQVLGHUWKDWWUDQVIHURI
WHFKQRORJ\ IURP 5' GHSDUWPHQWV WR FOLQLFDO WULDOV
DQGODWHUFRPPHUFLDOSURGXFWLRQLVFDUULHGRXWZLWK
ODFNRIVWULFWQHVVDQGSRRUGRFXPHQWDWLRQSUDFWLFHV
7KHUHIRUHWKH\ DUHHPSKDVL]LQJ RQ WKHFRQFHSW RI
F*03DVDTXDOLW\RYHUVLJKWFRPSULVLQJDOOSUDFWLFHV
LQ5'DQGSURGXFWLRQSURFHVVHV
7KH QHZ /\R%HWD 6HULHV O\RSKLOL]HUV DUH ODERUDWRU\
XQLWV WKDW KDYH EHHQ GHVLJQHG VSHFLILFDOO\ IRU
DGYDQFHG UHVHDUFK FHQWHUV NHHSLQJ LQ PLQG WKDW
LQLWLDOGHYHORSPHQWRIQHZGUXJVLVRQHRIWKHPRVW
FULWLFDOLVVXHVIRUWKHLUILQDOFRPPHUFLDOVXFFHVV
&RQWUROV\VWHP
%DVHGRQ3/&DQGXVHU
)ULHQGO\
728&+6&5((1
2QHRIWKHPDLQQHZIHDWXUHVRIWKH/\R%HWD6HULHVIUHH]HGU\HUVLVWKHLQFRUSRUDWLRQRIDQRQSURSULHWDU\3/&
LQVWHDGRIWKHFODVVLFPLFURSURFHVVRUPRUHFRPPRQO\XVHGLQWKLVW\SHRIHTXLSPHQW7KLVV\VWHPIXOO\SURYHQ
LQWKHLQGXVWULDOPRGHOVJXDUDQWHHVPD[LPXPUHOLDELOLW\DQGUHSURGXFLELOLW\LQWKHSURFHVVWRWDOO\DGDSWLQJ
WKHHTXLSPHQWWRF*/3
7KH V\VWHP DOORZV FRQWURO RI WKH IUHH]HGU\HU IXQFWLRQV YLD D JUDSKLF +0, +XPDQ 0DFKLQH ,QWHUIDFH XVHU
LQWHUIDFHZKLFKRIIHUVWKHIROORZLQJSRVVLELOLWLHV
‡'LVSOD\LQJRILQIRUPDWLRQRQV\VWHPHOHPHQWVYDOYHVPRWRUVLQGLFDWRUVHWF
‡5HFHLYLQJLQIRUPDWLRQIURPDODUPV
‡$FWLQJZLWKLQWKHSDUDPHWHUVRIWKHIUHH]HGU\HUF\FOH
‡(OLPLQDWLQJWKHSRVVLELOLW\RIHUURULQRSHUDWLRQ
‡3URWHFWLQJWKHV\VWHPIURPXQDXWKRUL]HGXVH
‡5HFLSHVGHYHORSPHQW
7KHXVHULQWHUIDFHSUHVHQWVLQIRUPDWLRQLQDQDWWUDFWLYHDQGLQWHOOLJLEOHPDQQHURQDJUDSKLF¨WRXFKVFUHHQ
WKURXJKZKLFKGLIIHUHQWGDWDVFUHHQVFDQEHDFFHVVHGE\PHDQVRIWRXFK]RQHV
2SWLRQDOO\WKHHTXLSPHQWFDQEHFRQQHFWHGWRGLIIHUHQWSHULSKHUDOVVXFKDVDFKDUWUHFRUGHUSULQWHU
RU3&:KHQFRQQHFWHGWRD3&WZRSRVVLELOLWLHVIRUZRUNLQJLQWKH:LQGRZVHQYLURQPHQWDUH
RIIHUHG
/\R/RJJHU
$GDWDORJJLQJSURJUDPPHZKLFKHQDEOHVFROOHFWLRQRIGDWDVXFKDVJUDSKVHYHQWVDODUPVDQGKLVWRU\
$6&,,ILOHVWKURXJKDVHULDOSRUW
/\R6XLWH
70
$6&$'$VRIWZDUHSURJUDPWRJHWKHUZLWKDVXLWHRIWRROVGHVLJQHGVSHFLILFDOO\IRUVFLHQWLILF5'
VWXGLHV,WHQDEOHVGHVLJQLQJORDGLQJDQGVWRULQJUHFLSHVJHQHUDWLQJUHSRUWVKLVWRULFVOLVWVRIDODUPV
HWFDVZHOODVPRUHVRSKLVWLFDWHGWHFKQLTXHVVXFKDVVHQVRUOHVVWHPSHUDWXUHPRQLWRULQJYLDWKH
LQQRYDWLYH'3('\QDPLF3DUDPHWHUV(VWLPDWRU
)UHH]H'U\LQJ(TXLSPHQW
/\R%HWD
7HFKQLFDOGDWD
8QLW
/\R%HWD
/\R%HWD
1XPEHURIVKHOYHV
)($785(
XG
6KHOYHVGLPHQVLRQV
PP
[
[
[
[
LQFKHV
[
[
[
[
P Z[G
8VHDEOHVKHOIDUHD
/\R%HWD
/\R%HWD
VTIW
&OHDUDQFH
PP
LQFKHV
6KHOIWHPSHUDWXUHUDQJH
ƒ&
¥D
¥D
¥D
¥D
&RQGHQVHUFDSDFLW\
NJ
OE
&RQGHQVHUFDSDFLW\LQK
NJ
OE
¥
¥
¥
¥
)LQDOFRQGHQVHUWHPSHUDWXUH
ƒ&
(OHFWULFSRZHU
N:
3RZHUVXSSO\ 9+]
,
,
,
,,,
RWKHUXQGHUUHTXHVW
RWKHUXQGHUUHTXHVW
9DFXXPSXPSIORZ
PK
RWKHUXQGHUUHTXHVW RWKHUXQGHUUHTXHVW
FIP
:HLJKW
NJ
OE
PPLQFKHV
'LPHQVLRQV
:LGWK
+HLJKW
PPLQFKHV
'HSWK
PPLQFKHV
$YDLODEOHRSWLRQV
‡9HQWILOWHU
‡6SDFLQJGHYLFHVIRUVKHOIFOHDUDQFHDGMXVWPHQW
‡6DPSOLQJWKLHIGHYLFH
‡&OHDQURRPFRQILJXUDWLRQ
‡6LGHPDQLIROG
‡3URGXFWVXSSRUWWUD\V
‡0RGXOHVIRUDGGLWLRQDOWHPSHUDWXUHSUREHVDQG
‡'HZSRLQWPRQLWRU
‡&KDUWUHFRUGHU
‡6&$'$5'O\RSKLOL]DWLRQVRIWZDUH/\R6XLWH
‡,424GRFXPHQWDWLRQVHUYLFH
6WDQGDUGDFFHVVRULHVLQFOXGHGLQ/\R%HWDHTXLSPHQW
‡9LDOVWRSSHULQJDQGVSDFLQJGHYLFH
‡,VRODWLRQYDOYHFKDPEHUWRFRQGHQVHU
‡'DWDDFTXLVLWLRQVRIWZDUH/\R/RJJHU
+HDGTXDUWHUV
$Y)RQWL6DJXp
7HUUDVVD6SDLQ
7
)
1RUWK$PHULFD
*UXQG\¶V/DQH
%ULVWRO3$86$
7
)
ZZZWHOVWDUOLIHVFLHQFHVFRP
,
7HOVWDUUHVHUYHVWKHULJKWWRLPSURYHPHQWVDQGVSHFLILFDWLRQVFKDQJHVZLWKRXWQRWLFH
70
www.telstar-lifesciences.com