Profiles in Excellence
Transcription
Profiles in Excellence
Unedited sample pages for reference only © 2016 P. T. Rajasekharan. All Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior permission of the Publishers. Panther Publishers Pvt. Ltd. 33, First Main, Koramangala First Block, Bangalore - 560034 Tel.: +91 80 4267 3400, Fax: +91 80 4267 3413 Email: info@pantherpublishers.com ISBN: 978-93-7787-128-4 Contents Introduction The Nobel Prize Physics Chemistry Physiology or Medicine 175 Literature 261 Peace 325 Economics 403 Index 443 xi xxi 1 89 PHYSICS I 1 1906 THOMSON, SIR JOSEPH JOHN Nationality: British. b. December 18, 1856, Manchester; d. August 30, 1940, Cambridge. In recognition of the great merits of his theoretical and experimental investigations on the conduction of electricity by gases Thomson studied at Trinity College, Cambridge and joined the faculty of mathematics of the same college in 1882. Between 1884 and 1919 he was Cavendish professor of experimental physics at Cambridge, a position that he succeeded from Lord Rayleigh. His son G.P. Thomson also won a Nobel Prize in physics (1937). Thomson gave a comprehensive account of the discharge of electricity through gases. His experiments led to the conclusion that the current in these discharges was carried by positively and negatively charged particles (ions) formed by the disruption of the chemical molecules of the gas. He determined the nature of the electrical particles by measuring their masses, and found that there was a more fundamental unit than the chemical atom – an atom of pure electricity, which in due course came to be called as electron. Thomson attempted to improve the technique and use it to calculate the masses, energies and electric charges of the other particles occurring in electric currents through gases. This research was important because it forecast the theory of nuclear as well as of atomic structure. His work was the beginning of the method of analysis now called mass spectrometry, extensively used in oil and other technologies. 1907 MICHELSON, ALBERT ABRAHAM Nationality: American. b. December 19, 1852, Strzelno, Prussia now Strzelno, Poland; d. May 9, 1931. Pasadena, California. For his optical precision instruments and the spectroscopic and meteorological investigations carried out with their aid Michelson graduated from the United States Naval Academy in mathematics and taught science there between 1875 and 1879. After travelling extensively in Europe and the United States, he became professor of physics at the Case School of Applied Science in Cleveland, Ohio (1883–1891). He joined the faculty of physics at the University of Chicago as its head in 1892. The first American physicist to be awarded a Nobel prize, Michelson made a fundamental contribution to modern physics by providing an accurate measurement of the speed of light with the help of ‘interferometer’ , an instrument he built. He also discredited the theory that light waves were carried through space by ‘ether’. His experiment carried out with Edward W. Morley, is famous in scientific history, and provided the theoretical basis for later work on relativity by Albert Einstein. Einstein drew directly on the results of Michelson’s experiments, using the idea that the velocity of light is constant as his basic premise. 1908 LIPPMANN, GAB’RIEL Nationality: French. b. August 16, 1845, Hollerich, Luxemburg, France; d. July 13, 1921 at Sea. For his method of reproducing colours photographically based on the phenomenon of interference Lippmann entered Ecole Normale, but failed in his examination, despite his ingenuity and promise in experiments. At Heidelberg, under the influence of Kirchhoff, he began his work on electro-capillarity, a subject that fascinated him. He became a professor at Sorbonne in 1883 and the director of Laboratories of Physical Research in 1886. 2 I chemistry 1903 and his determination of their place in the periodic system ARRHENIUS, SVANTE AUGUST Ramsay studied in Glasgow and then under the German chemist Bunsen, at Heidelberg. He served as a professor of chemistry at Bristol and later at London. Nationality: Swedish b. February 19, 1859, Schloso Wijk; d. October 2, 1927, Stockholm. In recognition of the extraordinary services he has rendered to the advancement of chemistry by his electrolytic theory of dissociation Arrheniusis best known for his contributions to the theory of electrolytic dissociation. The theory deals with the behaviour of certain substances when dissolved in water or other solvents, particularly under the influence of an external electric field. Arrhenius outlined his notions of electrolytic dissociation in his doctoral thesis, submitted in 1884. A more complete and refined version was published three years later. According to the theory, the fundamental particles an electrolyte consists of are separated in water solution by the action of water molecules. A sodium chloride molecule, for example, breaks apart to form sodium ions and chloride ions. The ions thus formed are similar to atoms, except that they carry electrical charges. Thomson’s discovery of the electron provided evidence of the divisible nature of atoms. The concept of ‘charged atoms’, once so inimical to chemical theory, was now a natural and understandable extension of atomic theory and this removed a major stumbling block in the way of chemists’ acceptance of the existence of ions. 1904 RAMSAY, SIR WILLIAM At Bristol he began his work on making the exact measurement of gas densities. In London, he began his famous work that explained the cause for the difference in atomic weight of nitrogen found in chemical compounds and the heavier free nitrogen found in the atmosphere. Rayleigh had demonstrated earlier that nitrogen from the air is 0.5% denser than nitrogen made chemically. Ramsay assumed this difference to be due to a previously unknown heavier gas in the air and set to work to find it. He sparked dry air to remove oxygen, and then passed the nitrogen repeatedly over hot magnesium, when most of the gas was slowly absorbed. What was left was a denser gas; an inert new element that was named argon that makes up less than 1% of the air. Ramsay liberated helium from the mineral clevite next. Examining air for further traces of new inert gases, he, along with Travas, discovered three more inert gases; krypton, xenon and neon. Later in 1910 he found the sixth gas, radon which is formed with helium by the radioactive decay of the metal radium. This group of gases is now known as the noble gases. 1905 VON BAEYER, JOHANN FRIEDRICH WILHELM ADOLF Nationality: German b. October 31, 1835, Berlin; d. August 20, 1917,Starnberg, near Munich. b. October 2, 1852, Glasgow; d. July 23, 1916, Surrey, England. In recognition of his services in the advancement of organic chemistry and the chemical industry, through his work on organic dyes and hydro aromatic compounds In recognition of his services in the discovery of the inert gaseous elements in air, Von Baeyer, a child prodigy, made his first new substance, the beautiful blue crystalline carbonate Nationality: British CHEMISTRY I 3 at the age of twelve. Student of two great masters of the time, Bunsen and Kekule, he was more influenced by Kekule and started his work on organic chemistry. He took his PhD in 1858 at Berlin and taught organic chemistry at a Berlin technical college for 12 years before moving to Strasbourg and then to Munich where he was a professor of chemistry for 40 years. borides and carbides of metals. He discovered silicon carbide and made the manufacturing of acetylene commercially feasible. He discovered many metals such as Mb, Ta, Nb, V, Ti, W and U, which were little known till that time. Von Baeyer’s works included the synthesis of indigo and the formulation of its structure. His work on the purine group began with the studies on uric acid, and included the synthesis of the useful drugs, the barbiturates. His study of the sensitively explosive polyalkynes led him to propose his ‘strain theory’ to account for the relative stabilities of carbocyclic rings. His other work dealt with hydrobenzenes and terpenes. BUCHNER, EDUARD 1906 MOISSAN, FREDINAND FREDERIC HENRI Nationality: French b. September 28, 1852, Paris; d. February 20, 1907,Paris. In recognition of the great services rendered by him in his investigation and isolation of the element fluorine, and for the adoption in the service of science of the electric furnace named after him The French inorganic chemist, Moissan had his initial education at Paris and later became professor of toxicology and inorganic chemistry there. He began his experiments to isolate the element fluorine in 1884 and two years later succeeded in isolation of fluorine by electrolysis of a solution of potassium fluoride gas at 50°C in an apparatus made of platinum and calcium fluoride. Fluorine was isolated at the anode as a yellow gas. Moissan attempted the synthesis of diamond by crystallising carbon from molten iron under pressure. He devised an electric furnace with a carbon arc that gave temperatures up to 3500°C, thereby founding a new area of chemistry. He made synthetic gems like ruby and silicides, 1907 Nationality: German b. May 20, 1860, Munich; d. August 13, 1917, Romania. For his biochemical researches and his discovery of cell free fermentation Buchner lost his father at the age of twelve, and his brother Hans (who later became a well-known bacteriologist) made it possible to complete his general education. In 1884, he started his studies in chemistry with Adolf von Baeyer and published The influence of oxygen on fermentation in 1885. After obtaining his doctoral degree from the University of Munich (1888), he joined as a lecturer in 1893 and started his experiments on rupture of yeast cells. The same year, he took over the supervision of the analytical department of Curtius’ laboratory and established himself as a professor in 1895. He was appointed to the chair of General Chemistry in the Agricultural College in Berlin where he obtained adequate assistance for his researches. Buchner’s research interests were twofold. Hepursued classical organic chemistry, often in collaboration with Curtius, in his studies of the aliphatic diazo- compounds, especially their reaction with benzene to give norcaradiene derivatives. Of more ultimate importance, however, was his work on fermentation, partly in collaboration with his elder brother Hans. It was during this brief period in Tubingen that he discovered the answer to a problem that had remained unanswered for decades. By grinding yeast cells with sand at controlled temperature he was able to prepare a cell-free extract that would ferment sucrose to ethanol, a property which he ascribed to an 4 I PHYSIOLOGY OR MEDICINE 1934 anemic patients lack a particular substance that helps absorb B12 in their gastric juice. MINOT, GEORGE RICHARDS Murphy took his MD from Harvard University (1920) and was associated with Peter Bent Brigham Hospital in Boston from 1922. He made special studies on diabetics and diseases of the blood, particularly with reference to liver treatment for pernicious anemia. Nationality: American b. December 2, 1855, Boston, USA; d. February 25, 1950, Brooklyn, USA. MURPHY, WILLIAM PARRY Nationality: American b. February 6, 1892, Stoughton, Wisconsin, USA; d. October 9, 1987, Brookline, Massachusetts, USA. WHIPPLE, GEORGE HOYT Nationality: American Following graduation (1905) Whipple trained in Pathology for two years. He first described a rare condition characterized by the deposition of fat in the intestinal and mesenteric lymphatic tissues, subsequently known as Whipple’s Disease. After a year in the Canal Zone, studying many tropical diseases such as anorexic dysentery, filariasis, and black water fever, he returned to Johns Hopkins where, from 1908 to 1914, his research centered on the liver, jaundice, and abnormal blood coagulation. For their discoveries concerning liver therapy in case anemia In 1914, Whipple became the director of the Hooper Foundation for Medical Research and professor of Research Medicine at the University of California in San Francisco. Despite the difficulties of fitting out a new laboratory in a wartime atmosphere, he continued his studies on bile formation in dogs, gradually extending this to include hemoglobin production and consequently, experimental anemia, on which he published over 200 papers. The American physiologist Minot and his fellow American Murphy reported the results of their successful treatment of pernicious anemia in 1926. Minot’s earlier work on blood disorders was continued at the Peter Bent Brigham Hospital, Boston, where he worked on the lethal disease, pernicious anemia. He retired as the Director of the Thorndike Memorial Laboratory in Boston. Along with Frieda Robbins, Murphy developed an experimental model whereby fixed quantities of blood were removed from dogs and the influence of various diets in the regeneration of blood cells was studied. They found that liver, kidney, and meat were (in that order) particularly effusive is simulating the bone marrow to produce new red blood cells. Following on the works of Whipple, who had demonstrated the control of excessive bleeding in dogs due to anemia, Minot and Murphy injected raw liver into patients and effectively reversed anemia. They developed an effective liver extract for oral consumption by patients and in 1948, isolated vitamin B12 (cyanocobalamine), a therapeutic anti-anaemic factor from liver extracts. Subsequent research has revealed that pernicious Liver expiree has already been suggested by Hopei in 1918 as particularly effective in the treatment of pernicious anemia in human beings, Hopper’s findings were neglected, but following Whipple’s reports, two Harvard physicians, George Minot and William Murphy began in 1926 to systematically investigate the use of liver and other foodstuffs in the treatment of pernicious anemia. b. August 28, 1878, Ashland, New Hampshire, USA; d. February 2, 1976, New York, USA. PHYSIOLOGY OR MEDICINE I 5 For these researches, Whipple, Minot and Murphy shared the Nobel Prize for Physiology or Medicine in 1934. The relationship between pernicious anemia and vitamin B12 deficiency was subsequently elucidated by other workers. The bile pigments were always of interest to Whipple but he also made important contributions to our knowledge of the blood proteins; to the mechanism of blood clot formation; and to the pathology of a genetic disorder which leads to anemia and other sequelae found in people of Mediterranean extraction, it was first named thalassemia by Whipple in his classic (1932) description of its pathology. 1935 SPEMANN, HANS Nationality: German b- June 27, 1869, Stuttgart, Baden-Wurttemberg, Germany; d. September 12, 1941, Freiburg-im-Breisgau, Germany. For his discovery of organizer effect in embryonic development Spemann began his experiments with eggs of newts since the eggs of these small lizardlike animals closely followed that of the other vertebrates, including man, in their development. The basic problem that he was trying to tackle was about how cells and tissues differentiate during growth. Spemann demonstrated that, by grafting tissue from one area of the developing embryo to another, the transplanted section can transfer its organizing power to its host’s embryo. He named this inducing bit of tissue “the organizer.” This discovery led to the conclusion that the specialization of the cells could be explained as an action of a special group of cells. The brilliant work and deduction of Spemann is especially significant since he did not know when he was operating so delicately on newts and salamanders that each cell carries a complete master plan for the whole individual and for all the specialized proteins needed to produce a newt, a salamander, or a human. 1936 DALE, SIR HENRY HALLETT Nationality: British b. June 9, 1875, London, UK; d. July 23, 1968, Cambridge, UK. LOEWI OTTO Nationality: German b. June 3, 1873, Frankfurt-amMain, Germany; d. December 25, 1961, New York, USA. For their discoveries relating to chemical transmission of nerve impulses Dale, the English physiologist and pharmacologist, was educated in Medicine at Cambridge, London and Frankfurt and joined the Wellcome Laboratories in 1904. Along with G. Barger, he studied the physiological action of ergot (a potent extract from a fungal infection of rye) and their work led to two research areas which are linked with their names. These are histamine, a compound released by injured cells of in reaction to foreign protein, and acetylcholine, the neurotransmitter. Dale’s work on acetylcholine as an agent in the chemical transmission of nerve impulses won him the Nobel Prize. His work also led to the fuller understanding of allergy and anaphylactic shock. Dale was the Director of the National institute of Medicine (1928–1942) and was a major spokesman for science in the UK. His writings include Adventures in Physiology (1953) and Autumn Gleanings (1954). He was Knighted in 1932. 6 I LITERATURE 1901 PRUDHOMME, SULLY RENE FRANCOIS ARMAND Nationality: French b. March 16, 1839, Paris; d. September 7, 1907, Chatenay. In special recognition of his poetic composition, this gives evidence of lofty idealism, artistic perfection and a rare combination of the qualities of both heart and intellect Sully Prudhomme, the French poet, was an important member of the Parnassians, who had, in the mid 19th century rejected the subjectivism of the romantics, in favour of poetry characterised by objective restraint and verbal and technical precision. His early verse was lyrical and subjective. Later he changed over to epical philosophic verse, a good example of which was his book La Justice (1878). He was scholarly and knowledgeable, and made a sustained effort to transform his extensive knowledge of science and philosophy into poetry. 1902 MOMMSEN, CHRISTIAN MATTHIAS THEODOR Nationality: German b. November 30, 1817, Garding, Germany; d. November 1, 1903, Charolettenburg. The greatest living master of the art of historical writing, with special reference to his monumental work, A history of Rome Mommsen was educated at Kiel and graduated in law. Influenced by his father, an assistant minister of the Protestant communities, he became a linguist learning many European languages like Greek, Latin, French, English, Swedish and Italian in addition to native German. In 1852 he became professor of Roman law at Zurich and his continued interest and mastery in ancient history and politics made him a Professor at Berlin. As a historian, he was like an artist of philology. His three volumes on roman History, Römische Geschichte (1854–1856) was a classic. It drew a more colourful and realistic picture of the age than had ever been achieved before. His other works include History of the Roman Coinage (1860), Roman Public Law (1876) and a book on philology, The Dialects of Southern Italy (1850). Mommsen reigned over German scholarship in the second half of the last century with imperial dignity. 1903 BJORNSON, BJORNSTJERNE MARTINUS Nationality: Norwegian b. December 8, 1832, Kvikne, Norway; d. April 26, 1910, Paris. As a tribute to his noble, magnificent and versatile poetry, which has always been distinguished by both the freshness of its inspiration and the rare purity of its spirit Dramatist, novelist and poet, Bjornson was a fore-runner of 20th century Norwegian drama, almost of comparable status with Ibsen. A much respected patriot and politician, he was at different times a newspaper editor and a theatrical manager, and often wrote on political issues. He was the author of Norwegian national anthem, and as much nationally minded as Ibsen was internationally minded. Initially he wrote historical plays in a light romantic spirit. But subsequently he moved over to naturalism and critical realism and wrote plays criticizing modern society. Thus he attacked the business morality in The Bankrupt (1875); attacked the blindness and hypocrisy of authority and advocated freedom of sex in A Gauntlet (1883); and wrote about the tragedy of religious LITERATURE I 7 1986 SOYINKA, WOLE Nationality: Nigerian b. 13 July 1934, Abeokuta, Nigeria Who in a wide cultural perspective and with poetic overtones fashions the drama of existence Despite its tendency to distribute awards along geopolitical lines, the Swedish Academy of Letters waited 85 years before bestowing the Nobel Prize for Literature on a black African. Yet when the laurel finally passed to Wole Soyinka, 52, a Nigerian playwright, poet, novelist, essayist and indefatigable polemicist, the justice seemed more than demographic. His works include: A Dance of the Forests (1960), a dreamlike, ritualistic celebration of Nigerian Independence edged with satire; Kongi’s Harvest (1965), a biting attack on a Nkrumah-like dictator. Soyinka has found widespread favour without ever courting it. His writings have charged the West with soulless materialism and his fellow Africans with barbarism and corruption. He has staked his art in a no-man’s-land between conflicting cultures. In his memoir Aké: The Years of Childhood (1981), Soyinka portrays the divided realms of his early impressions: the beliefs handed down by his mother and father vs. the animism of village rituals, particularly the tradition of the egúngún, the ancestral spirits who can be summoned whenever their masks are displayed at local festivals. After graduation he worked as a teacher and scriptwriter for London’s Royal Court Theatre, where some of his early sketches and short plays were performed. But he returned to Nigeria in 1960, the same year his homeland gained independence from British colonial rule. Soyinka’s adult career coincides almost exactly with the bushfire of nationalism that swept across Africa, a phenomenon that filled his writings with bursts of hope and despair. He eloquently expressed the ideals of Black Nationalism and spoke out harshly whenever they seemed in danger of being compromised or betrayed. In 1967 he was arrested by the Nigerian government, charged with assisting the Biafren rebels in their struggle for a separate state and held for 22 months. Soyinka later recounted this ordeal in the scathing prison memoir The Man Died (1972). Although he has become a folk hero in his native country, controversies have attended his career. Noting his fondness for Western literary forms (all of Soyinka’s work is written in English), some African critics have accused him of shunning his ethnic origins. 2007 LESSING, DORIS MAY Nationality: British b. 22 October 1919, Kermanshah, Persia (now Iran); d. 17 November 2013, London, UK. That epicist of the female experience, who with scepticism, fire and visionary power has subjected a divided civilisation to scrutiny Lessing’s family immigrated to Southern Rhodesia (now Zimbabwe), to a farm near the border with Mozambique, where she spent most of her time in loneliness. She did her formal education in a convent boarding school and later a girls’ school in Salisbury. Lessing has been largely selfeducated, after she decided to end her formal education at the age of 14. As a teenager, Lessing left home to escape loneliness and confinement and earned her livelihood by taking up jobs as an office worker, nanny, telephonist, journalist, and a typist. Her first marriage was short-lived and in 1945 she married Gottfried Lessing, a German emigrant to Southern Rhodesia, with whom she had a son. With a failed second marriage, Lessing 8 I LITERATURE immigrated to England with her son in 1949 and initiated her literary career the following year with her first novel The Grass Is Singing that depicted colonial Rhodesian society and apartheid. Lessing has remained highly committed to social and political responsibilities throughout her career and has served as a member of the British Communist Party from 1952 to 1956. Lessing was declared a “prohibited alien” in 1956 when she intensely criticised the racist policies of the South African government, at the same time being banned from her former homeland Southern Rhodesia. Lessing’s early fictions were works on her self-projection and exploration set in African backgrounds, in accordance with the 19thcentury literary tradition. Her first collection of short stories, This Was the Old Chief’s Country (1951), was followed by Martha Quest, the first of a five-volume semiautobiographical sequence that came to be known as the Children of Violence series (1952–1969). Lessing further enhanced her reputation with the publication of her postmodern novel The Golden Notebook, in 1962, a complex and disjointed narrative of a female protagonist’s psychological and emotional struggle to regain the sense of fulfilment and self-worth. During the 1970s and ’80s, Lessing published more-experimental fictions such as Briefing for a Descent into Hell (1971); The Summer Before the Dark (1973); and The Memoirs of a Survivor (1974). During this time she embraced the ideology of Sufism, especially the writings of the Indian-born mystic Idries Shah, which changed her perspective of the world as well as her artistic sensibility. Between 1979 and 1983 Lessing produced a five-volume sciencefiction series with the collective title Canopus in Argos. This was followed by The Diary of a Good Neighbour (1983) and If the Old Could… (1984), both written under the pseudonym Jane Somers. Later fiction included The Good Terrorist (1985), Love, Again (1996), The Sweetest Dream (2001), The Story of General Dann and Mara’s Daughter, Griot and the Snow Dog (2005), and The Cleft (2007). Notable works of nonfiction included African Laughter (1992), a bittersweet account of revisiting independent Zimbabwe; A Small Personal Voice (1994); and Time Bites (2004). In her autobiography in two volumes Under My Skin (1994) and Walking in the Shade (1997) Lessing recalls her life and describes scenes of England in the last days of the empire. PEACE I 9 1901 DUNANT, JEAN HENRI Nationality: Swiss b. May 8, 1828, Geneva; d. October 30, 1910, Heiden, Switzerland. For founding the International Committee of Red Cross Society and initiating the Geneva Convention Dunant was an eyewitness of the battle of Solferino in 1859. He published an appeal for, and organised emergency aid services for the wounded. He proposed the formation of voluntary relief societies to prevent and alleviate the sufferings caused by war and natural disasters. This led to the organisation of the Red Cross, which he founded in 1864, for which he won the Nobel Prize. Also the first Geneva Convention was the result of his efforts. Dunant’s negligence in business led to bankruptcy and he left Geneva in 1867 to live a life of poverty and obscurity until he was ‘rediscovered’ by a news paper in 1895. He continued to work for abolition of slavery, international arbitration and disarmament. The 1901 Nobel Prize was in recognition of his efforts on behalf of all these and for his Red Cross work. PASSY, FREDERIC Nationality: French b. May 20, 1822, Paris; d. June 12, 1912, Neuilly. For founding a French Peace Society Passy began his career as a lawyer. His concern for the peaceful settlement of differences between capital and labour and between nations led him to found the International and Permanent League of Peace in 1867, later known as the French Society for Arbitration Among Nations. He served in the Peace Society as a permanent secretary for over two decades. For these efforts he shared the first Nobel Prize with Dunant. With Sir William Cremer Passy established the Inter Parliamentary Union in 1889. He was elected to the Academic des Sciences Morales in 1877 and was a member of the Chamber of Deputies (1881–1889). 1902 DUCOMMUN, ÉLIE Nationality: Swiss b. February 19, 1833, Geneva; d. December 7, 1906, Bern. For his work as honorary secretary of the International Peace Bureau Élie Ducommun, Swiss journalist, eloquent lecturer, business executive, steadfast advocate of peace, was born in Geneva as a son of a clock maker. After completing his early studies at the age of seventeen, he became a tutor to a wealthy family in Saxony and remained there for three years, by which time he became an expert in the German language. He began his journalistic career in 1855 as an editor of a political journal, the Revue de Gene’ve and was in one way or another connected to journalistic enterprises for the rest of his life. Moving to Bern in 1865 he founded the radical journal Der Fortschritt or Progress; edited Helvetie (1871–1872); and from 1868 edited Les États – Unis d’Europe, a periodical of the International League of Peace and Freedom. Ducommun was also a prominent political figure and was a member of the Grand Council for nine years in Geneva becoming vice-chancellor in 1857 and chancellor of state in Geneva in 1962. 10 I ECONOMICS 1969 FRISCH, RAGNAR KITTIL ANTON Nationality: Norwegian b. March 3, 1895, Oslo, Norway; d. January 31, 1973, Oslo. For having developed and applied dynamic models for the analysis of economic processes Frisch studied at the University of Oslo and obtained his Ph.D. from there in 1926. He served as a professor in social economy and statistics at the same university from 1931 until his retirement in 1971. Frisch’s pioneering work in early thirties involved a dynamic formulation of the theory of cycle and had led a number of theoretical investigations concerning production, economic planning and national accounting. His contributions were significant in establishing basic concepts on models of whole economics, production, consumer behaviour, index numbers and planning. He was before his time in the building of mathematical models and his statistical and mathematical methodologies have applications in areas other than economics also. He was instrumental in establishing the Econometric society in 1930 and was the chief editor of its journal, Econometrica, until 1955. He also served as advisor to various developing countries, including Egypt and India. Fischer’s publications include Maxima and Minima – Theory and Economic Application (1966), Economic Planning Studies (1976) and New Methods of Measuring Marginal Utility (1978). TINBERGEN, JAN Nationality: Dutch b. April 12, 1903, The Hague, The Netherlands; d. June 9, 1994, The Netherlands. For having developed and applied dynamic models for the analysis of economic processes Tinbergen was born in The Hague and graduated from the University of Leiden and obtained his Ph.D. in 1929. He worked with the Central Bureau of Statistics, The Netherlands, between 1929 and 1945, with a brief two year stint (1936–1938) at the League of Nations Secretariat. He was the Director, Central Planning Bureau between 1945 and 1955 and taught for a very long period at the Universities of Leiden (1933–1973) and The Netherlands (1973–1975). In addition to serving as advisor to many governments, he was Chairman of the United Nations Committee for Development Planning in 1965. Tinbergen, along with Frisch, worked to lend economic theory a mathematical stringency, and to render it in a form that permits empirical quantification for investment and consumption expenditure, produced a wave movement with wavelength of 4 to 8 years and he could demonstrate how these wave movements became permanent and uneven rather realistic manner. Both of them, with the support of macroeconomic analysis, constructed theories for stabilization policy and long term economic planning, with a view particularly to the problems of the developing countries and made fundamental analysis of the theoretical basis of rational decision-making in the field of economic policy. During his impressive career, he worked with statistical models of economics, the mathematical analysis of economic cycles, and several other theories on income distribution, economic growth, economic planning and economic development. Tinbergen’s publications include An Economic Approach to Business Cycle Theories (1937), Statistical Testing of Business Cycle Theories (1939), On The Theory of Economic Policy (1952) and Economic Principles and Design (1956). He is the brother of Nikolaas Tinbergen, the 1973 Nobel Laureate in Physiology or Medicine and one of the founders of Behavioural Sciences. CHEMISTRY I 15