Year Report Julius Center 2007

Annual Report
Julius Center for Health Sciences
and Primary Care
Annual Report 2007
Julius Center for Health Sciences and Primary Care
UMC Utrecht
The Julius Center for Health Sciences and Primary Care is one of the
twelve divisions of the University Medical Center Utrecht (UMC
Utrecht). It carries out scientific research, provides education, and offers
expertise and facilities in the clinical health sciences field.
The Center aims for a leading and acquisitive position in the enlargement and dissemination of knowledge, especially in the field of health
sciences. This is done by means of groundbreaking research on four
disease-related themes and research methodology, by offering courses
for (bio)medical students, researchers and clinicians, and by providing
academic primary care.
Disciplines represented in the Center are general practice, (clinical)
epidemiology, nursing science, medical technology assessment, public
health, medical ethics, and nutritional sciences.
In this annual report the reader will find information on activities, output and finances in 2007.
Contact information
M. Kluijtmans, PhD
Executive Secretary Management Team & Coordinator Master’s
Programme Epidemiology
Julius Center for Health Sciences and Primary Care
University Medical Center Utrecht
Visitors: Heidelberglaan 100, Utrecht, The Netherlands
Correspondence: Str. 6.131, P.O. Box 85500, 3508 GA Utrecht,
The Netherlands
URL: www.juliuscenter.nl
E-mail: M.Kluijtmans@umcutrecht.nl
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Annual Report 2007
Contents
Introduction  7
Organization  17
Brief History  19
Organizational Structure  19
Research  21
Research Organization  23
Research Themes  26
IRAS  43
International Collaboration  45
External Assessment of Past Performance  50
Education  55
Educational Organization  56
General Practice  59
Epidemiology  67
Public Health  78
Medical Humanities  81
Nursing Science  83
Nutritional Science  87
Patient Care  91
Nutritional Sciences and Dietetics  93
Julius Center Health Care Leidsche Rijn  98
Unit Health Care Innovations  100
3
Operational Support  103
Management Support  105
Clinical Trial Services Unit  106
Data Management  108
Personnel and Finances  111
Personnel, Figures  113
Personnel, Listing  114
Financial Report  127
Research Projects 2007  133
Cardiovascular Diseases  135
Infectious Diseases  143
Cancer  148
Mental Health  150
Theoretical Epidemiology and Biostatistics  154
Miscellaneous  157
Clinical Trial Services Unit  161
Vasculair Imaging Center (VIC)  166
Data Management  167
Publications 2007  171
PhD Theses  173
International Refereed Publications  174
Professional Publications  201
Books and Book Chapters  205
Nederlandse Samenvatting  209
Colophon  224
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Annual Report 2007
5
Introduction
‘This year’s report again lists the many
international scientific publications by staff
members and fellows of the Julius Center which
underlines the Center’s continued success at the
forefront of international research.’
(Rick Grobbee)
The year 2007 started with a new management team. For a number of
reasons, not in the least the continuous growth of the Julius Center and
its activities, the team was expanded from three to four members. In
addition, the responsibilities of the members were rearranged. Professor
Diederick E. Grobbee remains the chairman of the division, with Margot
van der Starre, MSc, remaining director of business administration.
Professor Theo Verheij decided to leave the management team after
having served as the director of education for eight years. His position
was taken over by Professor Yolanda van der Graaf, while Professor Arno
Hoes was appointed as director of research, a position that was previously combined with the position of chairman. The management team
is supported by the executive secretary, Dr Manon Kluijtmans.
In the past years, several investments were made in the research support
and infrastructure. The research management information system was
further optimized and a start was made to upgrade the education management information system. In January a highly innovative in-house
developed data capture and management system was launched for use in
research projects : ‘Research Online: research without borders’. Research
Online is fully internet based, flexible and modular and can be applied
for projects of any size without any geographic or linguistic restriction.
Also in other domains, the impact of information technology could be
felt. The Dietetics section of the Julius Center was the first UMC Utrecht
care department to work fully digitally. Since January 2007 all patients
have an electronic file, the EPD, which can never go missing and is accessible form any location within the hospital. As UMU pioneers in comprehensive patient and workflow records, of course initial challenges and
difficulties were encountered. Many were solved satisfactorily and other
departments will likely benefit from these initial experiences.
Introduction
9
The Julius Center values education very highly and continues to invest
in the development of new teaching activities and improvements in
existing programmes. One of the major developments in 2007 was the
start of the AsiaLink programme. In collaboration with academic
departments in the United Kingdom (Oxford), Indonesia (Jakarta) and
Malaysia (Kuala Lumpur), and with support from the European Union,
the Julius Center aims to strengthen training and application of
Evidence Based Medicine in Asia. AsiaLink has resulted from long existing ties between the participating institutions and a history of annual
teaching courses in Asia by staff members of the Julius Center. Apart
from stimulating evidence based medicine, AsiaLink will promote teaching in clinical epidemiology by incorporating courses developed in
Utrecht and Oxford in the medical curricula in Kuala Lumpur and
Jakarta. Closely related to these activities, but more orientated towards
collaborative research, a local ‘Julius Center KL’ has opened at the
University of Malaya Medical Center in Kuala Lumpur in November
2007.
We cherish our stimulating and productive international collaborations.
As a reflection, the Julius Center has one of the highest travel budgets in
the UMC Utrecht. A more important reflection is, however, an increasing number of high level affiliations of staff members of the Julius
Center with prestigious academic institutions abroad. A prime example
was the appointment of Dr Petra Peeters as a professor in Chronic
Disease Epidemiology at the Faculty of Medicine, Imperial College
London in London, UK in October 2007. She will combine this position
with her activities as director of cancer epidemiology at the Julius
Center. Importantly, the appointment will further reinforce the existing
collaboration between these two institutes.
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Annual Report 2007
In addition to her scientific work and commitment to high quality
teaching, the Julius Center is also active in patient care. In 2007, the
Julius Health Care Centers in Leidsche Rijn (a residential area southwest of Utrecht) opened a fifth health center in ’t Zand, and the building
of a new health care center in Vleuterweide was commissioned. In its
health care centers, the Julius Center aims at setting new standards of
care. With regard to quality of care it is noteworthy that the managing
director of the Julius Health Care Centers, Rob van Damme, received the
first ECB certificate in the Netherlands. The ECB is a certification programme in which the clients judge on the provided care. It is an initiative of the Dutch Patients and Consumers Federation. With an average
client satisfaction of 8 the Julius Health Care Centers can be very proud
of their performance.
This year’s report again lists the many international scientific publications by staff members and fellows of the Julius Center which underlines
the Center’s continued success at the forefront of international research.
In 2007 the Julius Center again showed a good coverage in the major
high ranking and established medical journals; the JAMA, the New
England Journal of Medicine, and the Lancet. Senior staff members
Michiel L. Bots and Diederick E. Grobbee even managed to publish in all
three of these journals in one single year, a major achievement. Among
others they published two papers on the effects of lipid modifying drugs
on the development (progression) of atherosclerosis. Next to a good
representation in the aforementioned general journals, the Julius Center
had key methodological publications in major epidemiological journals,
as well as papers with immediate practice relevance in leading journals
in primary care.
Introduction
11
In addition to the excellent research output, Julius’ staff members
received awards and other expressions of appreciation of their research.
Two prizes deserve special attention: Bert Brunekreef, professor of
Environmental Epidemiology at the Julius Center and director of the
interfaculty Institute for Risk Assessment Sciences in Utrecht, received
two international awards in the month of September. In Mexico City he
received the ‘John Goldsmith Award’ from the International Society of
Environmental Epidemiology (ISEE). This award for ‘Outstanding
Contributions to Environmental Epidemiology’ is granted once a year to
someone who has made an exceptional effort in the area of environmental care and health. Professor Brunekreef is the first Dutch recipient of
this award. Only a few days later, on 15th of September he received the
‘European Lung Foundation Award’ in Stockholm. The ‘ELF Award’ is
granted once a year to someone who has made an exceptional effort to
improve public health.
Following intense evaluation of the structure and organization of the
Julius Center in 2006, a number of high impact decisions were made
about the way the Julius Center is organized and managed that influence
both its research and educational profile. After a long process of discussion and consultation the decision was made to terminate the department of Nursing Sciences in it present form. There appeared to be insufficient basis and prospects to continue the research activities in the area
of nursing science. The successful teaching programme in Nursing
Science will be continued in another format in close collaboration with
the Utrecht School of Professional Education. On a more positive note,
Utrecht University decided that as of mid 2008 the University Center for
Biostatistics will become part of the Julius Center. It will continue its
campus wide statistical consultation services, but strategic investments
will be made to foster original biostatistical research with a special
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Annual Report 2007
emphasis on epidemiologic and genetic statistical problems. With regard
to public health, a ‘Unit Health Care Innovation’ was established directed by Professor Guus Schrijvers to concentrate the advisory and evaluative work done on health care innovation.
Over the years, the Julius Center has introduced and refined a ‘matrix
model’ to direct and monitor its research and teaching. In this matrix,
education is being organized by scientific discipline and research by disease oriented research theme. To monitor the performance of the structure, a planning and control system was initiated in 2007 with increased
responsibility for the educational and research coordinators. This system
will be further improved and implemented in 2008. To support their
new role, several of the coordinating staff members involved enrolled in
personal and management development programmes. In addition, staff
development in general received attention, the acquisition of educational qualifications was stimulated and the board of the UMC Utrecht
granted no less than five female staff members of the Julius Center a
Steyn Parvé personal development award. The Steyn Parvé programme
comprises training and coaching and aims to support talented female
researchers in reaching academic top positions.
2007 was a year of evaluation. In two external research assessments by
international review committee’s the scientific performance of the Julius
Center’s was judged to be excellent. The committees also were very positive about the future prospects, and applauded the societal impact of the
Center.
Although it is impossible to capture the full range of the Julius center’s
activities in a short introduction, we can safely conclude that 2007 was a
very productive and successful year, in education and research as well as
Introduction
13
in patient care. The Center received excellent scores in external assessments of past research performance, and made important steps towards
securing these results for the future. Medical care in Leidsche Rijn
expanded with a high ambition in quality and patient satisfaction. Last,
but certainly not least, the educational activities remained of high quality, and attracted students from first year medical and biomedical bachelors to health care professionals.
The assessment of 2007 is positive and rewarding. But none of this
would have been possible without the people that together make up the
Julius Center. They are to be complemented for their creativity, hard
work, inspiration and devotion of many. Either being in support, care,
education, research or administration: thank you all for your commitment and I sincerely hope that this annual report will make you feel
proud and satisfied with the continued success of the Julius Center.
Professor Diederick E. Grobbee, MD, PhD
Chairman
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Annual Report 2007
Introduction
15
Organization
‘The Julius Center is and remains succesfull thanks
to the huge capacity of its researchers to acquire
funds, and the flexibility of all who support both
acquisition, administration and conduct of the
research projects.’
(Margot van der Starre)
Brief History
The Julius Center for patient-oriented research was established on 16
December 1996, founded upon the previous departments of epidemiology and public health, and on the hospital unit of clinical epidemiology.
Both scope and size have since then markedly increased, as is reflected by
the Julius Center’s subdivisions; former departments that have been
integrated in the current center. In 1999 the department of General
Practice merged with the department of patient-oriented research to
become the Julius Center for Patient-Oriented Research and General
Practice. In 2002 the department of Nursing Science and the Nutritional
Sciences group joined the Center to become the current ‘Julius Center
for Health Sciences and Primary Care’. In 2007 it was decided that
Nursing Sciences will be terminated in its present form in the division.
As per mid 2008, the Utrecht University Center for Biostatistics will
become part of the Julius Center.
Organizational Structure
The organizational structure can be found on the inside of the cover.
Organization
19
Research
‘We often gain more by improving timely diagnosis,
than by adding therapeutic interventions.’
(Arno Hoes)
Research
21
Research Organization
The University Medical Center Utrecht has formulated seven main
research themes. These fit into a matrix with four disease-related themes
on the horizontal and three methodological themes on the vertical axis.
The Julius Center’s main contribution to the total body of research of
the UMC Utrecht is through the research theme ‘Epidemiology’. With
rare exceptions, all of the Center’s research activities can be classified as
‘clinical epidemiological’ research, i.e. etiologic, diagnostic, prognostic
and intervention research with relevance for patient care. Building upon
this, the Julius Center contributes to all four disease-related areas of
research: cardiovascular disease, infection & immunity, cancer, and mental health. In addition, there are strong links with the other two methodological research themes of the UMC Utrecht: ‘Imaging sciences’ and
‘Genetics’.
The Julius Center’s research activities focused on 5 research themes, i.e.
the same 4 disease-related areas as the UMC Utrecht (Cardiovascular
Disease, Infection & Immunity, Cancer, and Mental Health) and one
methodological theme (Theoretical Epidemiology & Biostatistics).
Within these themes, there is further focus on subfields, as for example
research on (etiology and prognosis of) diabetes mellitus as part of the
cardiovascular disease theme or on the effects of vaccinations within the
infection & immunity theme.
All 5 research themes are headed by one (or two for the largest theme,
cardiovascular disease) research coordinator. Importantly, the research
activities of the (clinical or methodological) disciplines represented in
the Julius Center (Clinical Epidemiology, General Practice/Primary
Care, Public Health/Medical Technology Assessment/Medical Ethics,
Nursing Science, and Nutritional Sciences) are also incorporated in
Research
23
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these 5 research themes and not in separate research organizations. The
research methods for all of these disciplines can be broadly categorized
as (clinical) epidemiological, which was one of the main reasons for
these disciplines to be combined within the Julius Center. The research
activities can, thus, be represented by a matrix structure, in which the
vertical axis comprises the five research themes and the disciplines are
depicted in the horizontal axis. The Center’s policy is to concentrate its
research as much as possible on the matrix’s overlapping areas so that
each of its disciplines benefit most from the Center’s scientific and clinical expertise and the UMC Utrecht’s scientific themes as a whole are
strengthened.
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of Prof. Bert Brunekreef and honorary appointee Prof. Dick Heederik.
There is also collaboration with other epidemiological research groups
at Utrecht University, in particular with the Pharmaco-epidemiology
group (from the Pharmacy Department) and Veterinary Epidemiology
groups.
In addition to the acquisition and conduct of its own research projects,
either independently as an institute or in collaboration with other
research groups, a major responsibility of the Center is to provide methodological advice and to support clinical research in virtually all departments of the University Medical Center. Staff members act as consultants for research methods on a range of clinical investigations within as
well as outside the UMC Utrecht. The Center also plays a pivotal and
formal role in quality assurance of randomized trials performed in the
UMC Utrecht. These are important and growing activities for the Julius
Center. For many clinical departments the intense and continuous interaction with epidemiology has resulted in joint appointments of staff,
including the departments of anesthesiology, neurology, cardiology,
cardio-thoracic surgery, internal medicine, psychiatry, radiology and
pediatrics.
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The Julius Center has a formalized link with the interfacultary Institute
for Risk Assessment Sciences (IRAS), environmental and occupational
epidemiology at UU. This has been embodied by the joint appointment
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Annual Report 2007
Research
25
Research Themes
Cardiovascular Diseases
The disease-based research line Heart and Vascular Disease is the largest
research line in the Julius Center. A considerable part of the research
carried out within this research line focuses on the causes, diagnosis,
prognosis and therapy of cardiovascular diseases. The approaches
include the full range of epidemiological research methods, including
multi-centered randomized controlled trials to study the effects of preventive and therapeutic interventions.
Within the research line focus is on atherosclerosis progression as this
underlies the occurrence of ischemic vascular disease. In 2007 results
from several large international multicenter trials conducted by the
Julius Center on the effect of lipid modifying drugs were published. In
the METEOR study statin treatment slowed progression of atherosclerosis, assesses as carotid intima-media thickness, in a population of healthy
men and women, free from previous vascular disease and diabetes and
with a low Framingham risk score (JAMA. 2007;297:1344-53). A multicenter international trial among familial hypercholesterolemia patients
(RADIANCE I) on the effect of increasing HDL cholesterol levels by
cholesteryl ester transfer protein inhibitor on atherosclerosis progression
showed no benefit of the intervention (N Engl J Med. 2007;356:162030). Similar results were found in RADIANCE II among patients mixed
dyslipidemia (Lancet 2007;370:153-60). Findings from a large national
trial on the effect of folic acid supplementation on carotid atherosclerosis progression in expected in 2008.
With respect to large population based cohort studies several initiatives
were completed in 2007. A large, population based cohort study was
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Annual Report 2007
started in Utrecht in 1993, as part of the European Prospective
Investigation into Cancer and nutrition (EPIC). Women participating in
the national breast cancer screening programme and living in Utrecht
and surroundings were invited to participate between 1993 and 1997,
and 17,357 could be enrolled in Prospect-EPIC. Extensive information
on lifestyle behavior, such as smoking, alcohol consumption, physical
activity, and dietary habits were collected at baseline. Also a brief physical examination was done, for collecting information on anthropometry
and blood pressure. Serum, plasma, erythrocyte and DNA samples were
collected and stored locally as well as centrally in Lyon, France.
Information on cardiovascular, cancer and diabetes morbidity and mortality is collected through linkage with registries, such as the Cause of
Death registration at the Central Bureau of Statistics, the cancer registries from the Comprehensive Cancer Centres, and the national hospital
discharge diagnosis registry, and through follow-up questionnaires to
participants. Information on type 2 diabetes was verified through general practitioners and pharmacies. The National Institute for Public Health
and the Environment also contributes a cohort to EPIC, the MorgenEPIC-cohort. Since there has always been close collaboration between
the Dutch investigators, and baseline measurements are identical for
both cohorts, it was decided that the cohorts would be combined into
the EPIC-NL cohort. This major enterprise started in 2006, and was successfully finalized in 2007. The EPIC-NL cohort now consists of 40,000
men and women aged between 20 and 70 years, with 10 years of followup, 2000 cardiovascular disease cases, 2000 cancer cases, and 750 diabetics. In 2008 cardiovascular risk factors will be measured in the cardiovascular and diabetes cases, and a random sample of the cohort, in order to
have a set ready for extensive analysis and exciting papers. Information
can be found at www.epicnl.eu.
Research
27
A second large population based cohort of within the Julius Center is the
Utrecht Health Project. All new inhabitants in the newly developed large
residential area Leidsche Rijn, part of the city of Utrecht, are invited by
their general practitioner to participate in the Utrecht Health Project
(UHP). Informed consent is obtained and an individual health profile
(IHP) is recorded by dedicated research nurses. The IHP is the starting
point for the UHP research database as well as for the primary care electronic medical records. Follow-up data are collected through continuous
linkage with the computerized medical files recorded by the general
practitioners. UHP staff in each practice takes care of quality management of registration as well as data handling. Currently, over 50% of
invited new residents in the area have given informed consent with
­participation steadily increasing. At present over 10,000 inhabitants are
participating in Utrecht Health Project. Information is available at
www.lrgp.nl.
Using the infrastructure of the Utrecht Health Project, a weight reduction programme was initiated and finished in 2007. The aim was to
reduce weight and subsequently reduce cardiovascular risk in 180 overweight subjects (BMI 28-35). The project involved efforts and intense
collaboration of various health care workers: general practitioners,
­physiotherapists, dieticians. In addition to weight and risk reduction, the
process of the programme was carefully evaluated. A factor that was
related to success of weight reduction in particular was the direct contact of the patient by the general practitioners outside his regular
appointments. The weight reduction programme was designated as
being very innovative by the Dutch Minister of Health.
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Annual Report 2007
Also making use of the infrastructure of the Utrecht Health Study, a
study started into the early roots of cardiovascular disease in the young,
in which indicators of vascular damage are being studied in 6 year old
children. Using state-of-the-art ultrasound techniques information on
the thickness of the arterial wall and on the stiffness of the arterial wall
is collected.
Furthermore, with in the research line, studies are being conducted on
genetic information and the interplay between genes and environment
in, for example, studies on genetic and non-genetic factors that determine the occurrence of type 2 diabetes. The studies are conducted in
close collaboration with partners within and outside the UMC Utrecht
and abroad. In addition, the Center is involved in the setting up and scientific evaluation of both diagnostic and therapeutic heart failure outpatient departments in the broader Utrecht region. The purpose of this is
to gain a better understanding of the nature and causes of heart failure
and to improve early detection and adequate treatment and follow-up of
this syndrome, which constitutes an increasing burden on our ageing
society. Other studies include the etiology and prognostic role of coronary collateral formation, and the risk-benefit ratio of anticoagulation
in patients at a high risk of stroke.
In addition, the Julius Center is increasingly involved in the execution of
large-scale diagnostic studies, aimed at improving the early detection of
cardiovascular diseases, both in the population at large and in patients
requiring the hospital’s primary care unit. These include studies on the
added value of, e.g., various diagnostic imaging techniques and early
(bed-side) biomarkers in recognizing atherosclerotic disease (such as
stroke, coronary artery disease, peripheral arterial disease) as well as
heart failure, deep venous thrombosis and pulmonary embolism.
Research
29
Infectious Diseases
Infectious diseases research at the Julius Center is centered around five
topics:
1 Prevention, diagnosis and prognosis of respiratory tract infections.
This research is mainly positioned within the primary care and Ear
Nose and Throat area and, as an example, it is investigated to what
extent certain patient characteristics predict an abnormal and serious
clinical progression of bronchial infections, and what the
consequences for treatment and patient advice are. In addition,
antibiotic use and indications for prescribing in general practice are
being studied. This research has been expanded to the development
of asthma and allergy, in relation to exposure to infectious agents and
other environmental determinants, both in young children and in
occupationally exposed subjects.
2 Efficacy (and cost-efficacy) of vaccination strategies.
In collaboration with the department of Pediatric Immunology, the
National Vaccine Institute and pharmaceutical industries an
increasing number of vaccination studies have been executed and are
ongoing. Apart from these studies, the role of confounding in
determining vaccination efficacy is investigated.
3 Mathematical modeling of infectious diseases.
In collaboration with the Mathematical Institute of the University
Utrecht and the National Institute of Health and Environment, the
dynamics (and prevention of acquisition) of multi-resistant bacteria
and influenza within hospitals and the community at large is being
investigated, as well as potential effects of intervention. In 2007 a
collaboration between the National Institute of Health and
Environment, the Mathematical Institute, the Veterinary Faculty and
the Julius Center resulted in the Utrecht Epicenter for the study of
Infectious Disease Dynamics.
4 Infections in patients with diabetes mellitus.
The project ‘Development and evaluation of an educational
programme on the prevention of complicated infections in patients
with diabetes’ is currently being carried out. It focuses on respiratory
and urinary tract infections. New research topics include the
treatment of urinary tract infections and the relationship between
onychomycosis and the diabetic foot.
5The effects of nosocomial infections and transmission of antibioticresistant bacteria on patient outcome.
The attributable mortality of ventilator-associate pneumonia is
investigated and the Julius center coordinates a international clusterrandomized trial in European ICUs to determine the efficacy of
several approaches to reduce the transmission of antibiotic-resistant
bacteria.
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Annual Report 2007
Cancer
Cancer research at the Julius Center focuses on the etiology, early diagnosis and prognosis of hormone dependant cancer, predominantly in
women. With approximately 30,000 new cases a year amongst Dutch
women, cancer is a serious health threat. However, the known causes can
explain barely 30% of the cases encountered. An explanation for this
rather low percentage may be sought in the fact that environmental and
hormonal factors are predominantly studied without any consideration
to genetic predisposition. Cancer etiological research within the Julius
Center strongly focuses on the interaction between genes, hormones and
the environment (or lifestyle habits). For the study of genetic determinants or gene-environmental interactions, the Julius Center has access to
biological material originating from two large-scale on-going population-based cohorts, DOM and EPIC-NL, which is a merger of the two
Research
31
Dutch cohorts participating in the European Prospective Investigation
into Cancer and Nutrition: Prospect-EPIC and Morgen-EPIC.
For studies of the optimal (early) diagnostic and (clinical) follow-up
procedures in cancer patients, collaboration has been established with
clinicians from other departments of the University Medical Center in
Utrecht. Examples are the COBRA and MONET studies, both assessing
optimal diagnostic and therapeutic procedures in women with non-palpable breast diseases. Studies to assess ‘quality of life’ and evaluate ‘nurse
practitioners’ in the daily care of cancer patients also fall in the domain
of the oncology research at the Julius Center.
In 2007, Petra Peeters, the head of the cancer research group, was
appointed Professor of Chronic Disease Epidemiology at the Faculty of
Medicine of Imperial College London in London, UK.
1 The presentation of depression in primary care, and its association
with somatic disease such as dementia, diabetes, gastro-enterological
and vascular disease.
2 Functional disease and somatoform disorders: presentation,
determinants and treatment in primary care
3 Psychiatric morbidity in relation to socio-demographic context and
consultation patterns
Mental Health
The Julius Center’s psychiatric epidemiology section studies psychiatric
disease and related co-morbidity in primary care and the general population. Mental illness represents a sizeable proportion of the global burden of disease in the general population, but is only partly presented to
health care professionals. Major psychiatric disease represents 5% of the
prevalent morbidity in primary care, with an annual prevalence of 125
per 1000 patients. A substantial part of minor psychiatric morbidity is
presented in relation to somatic disease or functional syndromes or
expressed through excessive consultation frequency of unexplained
functional syndromes. Mental illness is - though closely linked to
somatic ill-health - traditionally studied in isolation. The psychiatric
epidemiology section focuses on the study of somatic - psychiatric
comorbidity, with the following themes:
These themes are studied on the various levels at which disorders manifest themselves:
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Annual Report 2007
The common background hypothesis is that somatic and psychiatric
disorders share an overlapping etiology and that this overlap has social
and psychological as well as physiological components. Our assessments
typically aim to characterize individuals on several levels (psychological,
physical and physiological).
-The general population, by using existing and developing sampling
frames such as LRGP (Leidsche Rijn Gezondheidsproject), NEMESIS
(Netherlands Mental Health Survey and Incidence Study), AGIS health
database and others.
-Primary health care, in primary care networks such as HNU
(Huisartsen Netwerk Utrecht), PREDICT, the Julius Gezondheids­
centra in Leidsche Rijn and the database of Emergency Primary Care
service in the Gelderse Vallei area.
-Populations of people with reported mental illness like those registered
in our psychiatric case registry (RIPAG).
-Populations of people with reported somatic illness, such as samples of
cardiovascular compromised patients (SMART), (pre)diabetic patients
(UDES), and medication-using people (PHARMO).
Research
33
This approach of studying the phenomenon of somatic psychiatric
comorbidity on various levels of the health care system is unique. From
a clinical point of view it will yield information on the etiology and
prognosis of somatic-psychiatric co-morbidity, and allow preventive
interventions. It will also facilitate evaluation of the patient flow through
the mental health care system, and its effectiveness
-Investigating innovative methods for meta-analysis and individual
patient data-analysis of therapeutic studies.
-Development of models to combine data from randomized and
observational studies including genetic information, for estimating
(long term) prognosis according to specific patient characteristics in
addition to treatment effects.
Most research projects are carried out in collaboration with partners
within primary or secondary care health care: primary care physicians,
secondary care centers for psychiatry, neurology and gastro-enterology,
often in cooperation with other (international) academic centers.
Notably the improvement of methods for design and analysis of multivariable diagnostic and prognostic research is unique. Most research in
this field focuses on single test evaluations rather than evaluations in a
clinical context, accounting for other test results. But also the methodology for modeling data from randomized and non-randomized studies
combined, is in its infancy. This type of research is situated at the crossroad of clinical epidemiology and medical technology assessment.
Theoretical Epidemiology and Biostatistics
Besides more applied studies on improving insights in the etiology, diagnosis, prognosis and therapy of specific disorders, the Julius Center also
aims to further develop the theory and methodology of the discipline
itself. The section Methodology conducts studies aiming to improve
existing methods and to develop innovative methods for design and
analysis of (clinical) epidemiological studies. The section focuses on the
following themes:
-Developing innovative designs for diagnostic and prognostic
(prediction) research.
-Developing innovative methods for quantifying the true value or
contribution of (new) diagnostic and prognostic tests in a
multivariable clinical context.
-Developing innovative methods for the validation and updating of socalled clinical prediction rules.
-Testing and improving sophisticated methods for dealing with missing
values in epidemiologic research.
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Annual Report 2007
All above methodological themes are not only studied on a purely theoretical level, but are also applied by using empirical data from various
medical disciplines, notably from the four disease-oriented sections of
the Julius Center. For example, data are used from the above-mentioned
LRGP (Leidsche Rijn Gezondheidsproject), the Predict study and the
AMUSE study, and from other large ongoing studies in the UMC
Utrecht. It may be obvious that the results of our methodological studies
do not only serve the clinical domains studied, but may serve all medical
domains in which e.g. diagnosis, prognosis and therapy are at issue.
Most methodological projects are carried out in close collaboration with
other clinical departments from the UMC Utrecht. Other epidemiological and (bio)statistical departments from national an international academic centers are also consulted, such as the Utrecht University,
Academic Medical Center Amsterdam, Erasmus Medical Center
Research
35
Rotterdam, Dutch National Institute for Health and the Environment,
Vanderbilt University (USA), Harvard University (USA) and Oxford
University (UK).
Cohorts
The Julius Center coordinates and participates in several large research
cohorts. These cohorts are an important base for research and provide
ample opportunities for obtaining financial research support. Moreover,
the projects of the GP-network Utrecht and the Utrecht Health Project have
the intention to create an infrastructure in which research questions on
efficacy and effectiveness of health care, and effects of (local) health care
policy, can be answered. The latter is of major importance for increasing
the expertise in the areas of health care improvement, extramural health
care, and general practice.
The major cohorts are:
AGIS Health database
The AGIS Health database is a registry of all health care procedures of 1.7
million health insured persons. It contains data on health care procedures
by all contracted health care providers such as general practitioners, specialists, physiotherapists, pharmacists, midwives and hospitals. Besides data
on health care procedures in primary (consultations, referrals, prescriptions)
and secondary care (consultations, prescriptions and procedures), a number
of personal characteristics are documented, such as date of birth and gender. The insured persons are representative of the Dutch population. The
purpose of the database is to improve knowledge on health care consumption, interaction between primary, secondary care and public health, and to
provide data to support health care management and to improve quality
of care.
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37
ARYA
this study is to assess the relation between nutrition and cancer and other
The Atherosclerosis Risk in Young Adults (ARYA) study is an unselected birth
chronic diseases. Participants filled out lifestyle and medical questionnaires
cohort of 750 persons born in between 1970 and 1973 in and around the
and extensive food frequency questionnaires. From all participants blood
city of Utrecht. Its research focus is on early life determinants of later life
samples were drawn, fractionated and stored at -196 C.
cardiovascular disease. At birth, participants had elaborate registered birth
data available at the Municipal Health Service in Utrecht and they were fol-
HNU
lowed up into young adulthood. In 1999, participants underwent elaborate
The HNU (Huisartsen Netwerk Utrecht = Utrecht General Practice Network)
cardiovascular disease risk profiling, including classical cardiovascular dis-
was funded in 1989 and is a collaboration between the General Practice
ease risk factors as well as elaborate non-invasive arterial wall
department of the Julius Center and around 35 general practitioners work-
measurements.
ing in six primary health care centers in the Utrecht area. Approximately
60,000 patients are enlisted with these centers. Data on all primary care
DOM
consultations (including the ICPC coded diagnosis), prescriptions and refer-
The DOM cohort (Doorlopend Onderzoek Morbiditeit en Mortaliteit =
rals in these patients are encoded in the database. GP’s were trained to
Ongoing Study on Morbidity and Mortality) is a cohort of 50,000 healthy
ensure high quality coding. The primary goal was to set up a network of
women, living in Utrecht and surroundings. They were recruited from
practices that could provide valid and detailed routine care data on a pri-
among breast cancer screening participants, 50-70 years at recruitment in
mary care cohort for observational studies. Nowadays, the HNU has a large
1974-1986. The purpose of the DOM study is to identify risk factors for sev-
centralized database with observational data on the patients enlisted from
eral chronic diseases, especially (breast) cancer and cardiovascular diseases.
1995 up until 2006.
Baseline measurements included a short medical examination, and extensive lifestyle and medical questionnaires. Overnight urine samples were col-
PIAMA
lected and stored at -20 C.
The PIAMA (Prevention and Incidence of Asthma and Mite Allergy) birth
cohort includes circa 4,000 children who have been followed for 8 years
EPIC-NL
since birth. It is a multi-centre study including IRAS/Julius Center, National
EPIC-NL is the Dutch contribution to European Prospective Investigation
Institute of Public Health and the Environment (RIVM), Erasmus University
into Cancer and Nutrition. EPIC-NL (www.epicnl.eu) is a merger of the
Medical Center Rotterdam, University Medical Center Groningen and
Prospect cohort (coordinated by the Julius Center) and the MORGEN-EPIC
Sanquin/CLB Amsterdam. The study was started in 1996 and its purpose is
cohort (coordinated by the National Institute of Public Health and the
to investigate the occurrence of asthma and allergy in young children, as
Environment (RIVM), Bilthoven). It is a cohort of over 40,000 men and
well as lifestyle and environmental risk factors for these diseases. At several
women from Amsterdam, Doetinchem, Maastricht and Utrecht and sur-
points in time, data were collected on exposure and health status. Blood
roundings, aged 20-70 years at recruitment in 1993-1997. The purpose of
samples were collected in a sub sample of the children
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Research
39
PREDICT
SMART
This is a prospective study in which consecutive general practice attendees
The SMART (Second Manifestations of ARTerial diseases) cohort started in
in six European countries are recruited and followed up after six and 12
1996. It is an ongoing prospective single-center cohort study of patients
months for the prevalence of depression. The Dutch part is coordinated by
with cardiovascular risk factors or clinically manifest arterial disease. The
the Julius Center. Its purpose is to develop a risk score for use by general
purpose is to screen these patients for vascular problems elsewhere in the
practitioners to predict the onset and maintenance of depression.
body. Consecutive patients aged 18 to 80 years, referred to the University
Recruitment was started in 2003 and participants were 18-75 years old.
Medical Center Utrecht (UMCU), with manifest arterial disease or a cardio-
Over 10,000 participants were included, among which over 1,000 partici-
vascular risk factor underwent vascular screening including questionnaire,
pants in the Netherlands.
blood chemistry, and ultrasonography. After this screening, all patients
biannually fill out a questionnaire in order to collect information on cardio-
PROVIDI
vascular morbidity and mortality as well as diabetes mellitus endpoints.
PROVIDI is a cohort of ca. 16,000 patients who have undergone a chest mul-
SMART includes over 7,500 patients with more than 10 years of follow-up.
tislice Computed Tomography (msCT) scan for diagnostic reasons. The purpose of the cohort is to investigate the extent to which unrequested imag-
Utrecht Health Project (LRGP)
ing findings are of prognostic relevance for the occurrence of several rele-
The Utrecht Health Project (or Leidse Rijn GezondheidsProject (LRGP)) is a
vant diseases, other than the diagnostic CT was originally indicated for.
cohort of over 10,000 residents of the Leidsche Rijn, Utrecht area, who have
been included through their general practitioners. The purpose of this
RIPAG
study is to enable research on the impact of changes in health care policy,
RIPAG-MWU (Regionaal Informatiesysteem Patiënten Geestelijke
developments in community and public health and determinants of health
Gezondheidszorg Midden-Westelijk Utrecht) is an anonymous psychiatric
and disease during lifetime, as well as quality management of (primary)
case registry that contains information on people who have been treated in
health care itself. Individual health profiles have been made at recruitment
a regional mental health care center. It is one of the four regional psychiat-
and follow-up data are collected through continuous linkage with comput-
ric registries that are supported by the Ministry of Health. The primary aim
erized medical files recorded by the general practitioners. Blood samples
of the database is to provide and analyse epidemiological data on mental
were collected as well.
health care, to provide management support and to improve quality of
care. All major institutions for mental health care in the central region of
Whistler
the Netherlands participate in the registry. From 1999 onwards data
Whistler (Wheezing Illnesses Study in LEidsche Rijn) is a satellite cohort of
(patient characteristics, DSM IV diagnosis, referring centre, type of care and
the Utrecht Health Project. Participants are newborns to inhabitants of
prescriptions on 2.7 million episodes of 60,000 patients who were treated
Leidsche Rijn. Whistler was originally initiated to study early life predictors
for mental health problems have been included in the database.
of (lower tract) respiratory disease in childhood. The focus is now expanded
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Research
41
to cardiovascular disease research questions as well. Currently, some 1,800
IRAS
newborns are included in Whistler. The ultimate purpose is to follow participants up until adulthood.
Extensive descriptions of cohorts and related websites can be found at:
http://www.juliuscentrum.nl/julius/Research/cohorts
IRAS, the Institute for Risk Assessment Sciences (IRAS), is an interfaculty research institute within the Utrecht University faculties of Veterinary
Medicine, Medicine and the faculty of Science. The institute has a dual,
complementary mission. It performs interdisciplinary research that concentrates on risk assessment of chemical, physical and biological agents
on man and the environment. It also provides education and training of
graduate and postgraduate (PhD) students in the disciplines of toxicology, environmental and occupational health and epidemiology. The
research is performed in three divisions: Environmental Epidemiology,
Toxicology, and Veterinary Public Health. Research within the
Environmental Epidemiology and Veterinary Public Health Divisions is
determinant-oriented epidemiological research, which in most cases is
conducted in close collaboration with groups from UMC Utrecht (Julius
Center, Heart and Lung Institute, Wilhelmina Children’s Hospital). The
IRAS input to collaborative projects involves exposure assessment methodology and advanced exposure response modeling. Specific areas of
research are cancer and exposure to airborne particulate matter, poly­
cyclic aromatic compounds, dioxin, and organic solvents, asthma and
allergen exposure, immune modulation by exposure to Microbial
Associated Molecular Patterns (MAMPs). There is a particular interest
in exposure to infectious agents and in veterinary public health issues
including zoonoses and exposure to microbial agents through the food
chain.
The IRAS research performance over 2000-2004 was evaluated by an
international site visit in late 2005. The report issued in March 2006 gave
IRAS research the highest possible mark for quality, productivity, relevance and viability. IRAS as a whole produced about 140 peer-reviewed
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Research
43
journal articles in 2007, some 40 of which were co-authored by Juliuscenter affiliated professors Brunekreef and Heederik. In 2007 the Utrecht
Center of Molecular Epidemiology (UCME) was established. This center
is a collaboration between IRAS and the Julius center and provides core
lab-facilities to facilitate specimen handling, DNA extraction and a
diverse range of analytical techniques specifically targeted to large scale
epidemiological research. In addition, to the establishment of the center
plans have been developed to enhance the education curriculum on
molecular and genetic epidemiology Research collaborations with RIVM
have been strengthened. Infectious disease epidemiology has become
more prominent, and active collaboration with other colleagues in the
Julius Center is being developed.
International Collaboration
By nature of its scientific and educational activities, the Julius Center’s
playing field is the world. Research is conducted in collaboration with
research institutes and universities in many different countries. In addition to the inspiring and productive contacts between staff members and
fellows with peers all over the world, the Center aims to establish more
extensive long-term structural partnerships with strategically selected
high-quality Academic institutions. These contacts will play an important role in the Julius Center’s ambition to stay at the forefront of international health scientific research and to disseminate knowledge to an
international audience of students and health professionals
With the specific aim to expand its activities in major outcome trials, an
international alliance was created in collaboration with the George
Institute for International Health in Sydney, Australia, and the Berman
Center for Outcomes and Clinical Research, at the University of
Minnesota, Minneapolis, USA. The Academic Alliance for Clinical Trials
(www.academicalliance.com) is an academic research contract organization with a focus on interaction between the pharmaceutical industry
and academic investigators to promote high-quality innovative phase III
and phase IV clinical trials. The Alliance builds upon an existing network of clinics and health care centers in five continents. Besides designing and conducting research, the Alliance invests in improving the methodology and efficiency of research with ample attention to studies in the
developing world. In 2007 first major study was contracted.
In international education most important development in 2007 was the
start of the European Committee funded AsiaLink project. The Julius
Center, the Malaysian Ministry of Health and the University of Malaya
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Annual Report 2007
Research
45
Medical Center (UMMC) in Kuala Lumpur, Malaysia are nurturing a
growing collaboration. Until now the collaboration was predominantly
based on short intensive courses on clinical epidemiology and evidencebased medicine, delivered by the Julius faculty in collaboration with
local staff in Kuala Lumpur. The AsiaLink project aims to extend this
collaboration to cover three domains: a) Collaborative research for clinical trials and cohort studies, b) Development and creation of a regional
research infrastructure, c) Expansion of educational programmes that
also focus on the South Asian region.
With the project the international educational collaboration was extended to also include the University of Indonesia in Jakarta, Indonesia, and
the University of Oxford, United Kingdom.
will be largely conducted by local staff. An important purpose of these
courses is also the scouting and selection of bright young medical doctors for PhD fellowships. These PhD fellowships will be supervised by
the Julius staff and imbedded in the research lines of both the UMC
Utrecht and the UMMC. During the fellowship, candidates will follow
part of their education in the Netherlands, notably in the Epidemiology
prestige master’s programme. Depending on the subject, research will be
carried out at the Julius Center or in their home country.
With regard to clinical trials, Southeast Asia and Malaysia in particular
offers an excellent competitive environment for innovative pharmaceutical companies and large-scale-studies. It also has a growing burden of
chronic diseases that require attention. The shared interests and combined forces of the Julius Center and its Malaysian partners creates
unique research opportunities. The Ministry of Health’s department of
Medical technology has very good connections with all major hospitals
in the country and a keen interest in improving the quality and efficiency medical care. The partners have jointly created a ‘Julius-KL’ research
infrastructure in Kuala Lumpur that reflects the Julius Center philosophy. In order to foster high quality research, a robust research-support
section is needed in which project managers, research nurses, data managers, computer experts, trial monitors, and administrative personnel
have their basis. In cooperation with local staff, the Julius Center will
continue and broaden the programme of short courses on methods of
clinical research. These courses are targeted at medical doctors and clinical investigators in the Southeast Asian region. Eventually, these courses
In addition to clinical trials, the Julius Center is also participating in the
largest ongoing observational study on nutrition and health in Europe,
the EPIC Study. The European Prospective Investigation into Cancer
and Nutrition started with the collection of extensive dietary questionnaires, anthropometric measurements and blood samples in 10
European countries between 1992 and 1998. The Julius Center recruited
over 17,000 women. In addition to cancer, (healthy) longevity (EPICElderly), cardiovascular diseases (EPIC-heart), and diabetes have been
included as major focal points. There is a strong cooperation with 23
research centers of oncology and public health institutes and universities
across Europe. A new collaborative project called ‘EPIC-Heart’ provides
breakthrough epidemiologic research on causes and consequences of
cardiovascular disease using data and biologic material obtained from
520,000 subjects.
A major development in the expansion of international research contacts, and a spin-off of the collaboration in the EPIC project, is the
appointment in October 2007 of Petra Peeters as professor in Chronic
Disease Epidemiology at the Faculty of Medicine, Imperial College
London in London, UK. Petra Peeters is senior staff member of the
Julius Center and coordinator of the cancer research theme. Her parttime chair at the renown Imperial College London will reinforce the
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47
existing collaboration between the two institutes and stimulate both
research and educational collaboration.
The above initiatives are necessarily a selection of examples of international collaboration. Collaborations exist, among others, with the following institutions:
-Berman Center for Outcomes and Clinical Research, University of
Minnesota, Minneapolis, USA
-Department of Clinical Epidemiology, University of Pretoria, South
Africa.
-Clinical Trial Services Unit and Department of General Practice,
University of Oxford, Oxford, UK.
-Departments of Epidemiology and Nutrition, Harvard School of
Public Health, Boston, USA.
-Department of Cancer Epidemiology, Imperial College London,
London, UK.
-Department of Epidemiology, Karolinska Institute, Stockholm,
Sweden.
-Department of Epidemiology, UCSF, San Francisco, USA.
-Department of Food Science and Nutrition, University of Minnesota,
USA.
-Department of Health Evaluation Sciences, University of Virginia
Medical School, Charlottesville, Virginia, USA.
-Department of Neurology, University of Western Ontario, Ontario,
Canada.
-Department of Public Health, Wake Forest University, Winston Salem,
USA.
-Departments of Nutrition and Cancer, Hormones and Nutrition,
International Agency for Research on Cancer, IARC, Lyon, France.
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Annual Report 2007
-Framingham Heart Study, NHLBI, Boston University Medical Center,
Boston, USA.
-George Institute for International Health, Sydney, Australia.
-Medical Research Council London, UK.
-Medical Research Council, Dunn, Cambridge, UK.
-University of Indonesia, Jakarta, Indonesia.
-University of Malaya Medical Center (UMMC), Kuala Lumpur,
Malaysia.
-University of Tokai, Isehara, Japan.
-Wallenberg Laboratory, Sahlgrenska Hospital, Gothenburg, Sweden.
Research
49
External Assessment of Past Performance
A quote from the conclusion of the committee:
‘The Julius Center is a world renowned center for clinical epidemiology.
In 2007, the research performance of the Julius center was assessed by
two independent external review committees. The first assessment was
part of a review of all research groups of the UMC Utrecht; the second
assessment was part of a review of all research groups involved in the
Netherlands Institute of Health Science (Nihes), because of a renewed
accreditation of this graduate school by the Royal Dutch Academy of
Sciences (KNWA). Both international committees judged both past performance and future perspectives as excellent. The next paragraphs will
provide more detail on their findings.
It engages in all kinds of epidemiological research, from observational
studies and surveys to clinical trials and screening programmes. On
clinical epidemiology, there are a few other centers in Europe that can
compete with this division. In general this division, with its very high
publication output, is one of the pace setters for the UMC Utrecht.
Within the UMC Utrecht matrix, clinical epidemiology figures as a
­horizontal line, crossing through neurosciences, cardiovascular sciences,
immunology and infectious diseases and oncology. The research focus is
predominantly on cardiovascular diseases, but there is a growing
emphasis on immunology and infectious diseases. The collaboration
with oncology and neurosciences is developing. The relevance of clinical
epidemiology for both the research within the UMC Utrecht and the
public at large is great indeed. The future of this division is very good.’
In 2007 the University Medical Center Utrecht had its research 20012006 assessed by an international external review committee, according
to the Standard Evaluation Protocol (accepted in 2002 by the eight
University Medical Centers in the Netherlands). The overall conclusion
of the committee was that the UMC Utrecht as a whole combines a
unique spectrum of preclinical, translational and clinical research. The
research programme of the Julius Center, one of the twelve divisions of
the UMC Utrecht, received extremely high rates, both in absolute scores
as well as relative to the other divisions of the UMC Utrecht. On a score
scale of one to five, the research was judged as:
-Quality 5 (excellent: internationally leading)
-Productivity 4/5 (very good/excellent: internationally
competitive/leading and nationally leading)
-Relevance 5 (excellent: internationally leading)
-Vitality 4 (very good: internationally competitive,
nationally leading)
Also in 2007, the research performance of the Julius center was assessed
by an International Review and Advisory Committee, because of a
renewal of the accreditation of the Netherlands Institute for Health
Sciences (Nihes). The assessment concerned the three research themes
that participate in Nihes (Cardiovascular epidemiology, Cancer epidemiology and Theoretical epidemiology) and the research theme that will
part of Nihes from 2008 onwards: Epidemiology of infectious diseases).
The research themes Cardiovascular epidemiology, Cancer epidemiology
and Theoretical epidemiology all received the maximum score of 5
(excellent) on a scale of one to five.
To quote the assessment committee:
‘The research at this department is excellent and internationally lead-
ing. The committee very much appreciates the ambition of the department to raise the level of clinical research in daily practice by investing
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51
in prognostic and diagnostic research. The committee favours the view of
the department that it is important to have a strong research line on
theoretical epidemiology next to the applied epidemiological research.
The committee was impressed by the societal impact of the department.’
For the newly participating research theme, Epidemiology of infectious
diseases, received a score of 4 (very good). To quote the committee:
‘The committee values the research line of infectious disease epidemiolo-
gy as very good. Together with the research in this field by the department of theoretical epidemiology of the faculty of Veterinary Medicine,
and the affiliation with the Center for Infectious Disease Control of
National Institute of Public Health and the Environment in the near
future, this research line is growing to be a strong infectious disease area
of research.’
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53
Education
‘Education is what survives when what has been
learned has been forgotten.’
(B.F. Skinner, New scientist, May 21, 1964.
Aangeleverd door Yolanda van der Graaf)
Education
55
Educational Organization
The Julius Center participates in numerous educational programmes
covering a broad range of health sciences and primary care. The Center
actively participates in new educational developments such as the UMC
Utrecht’s ambitious undergraduate medicine programme (CRU’99),
which started in 1999 and is based on interdisciplinary problem-oriented learning, and SUMMA, a new 4-year medical grade programme that
started in 2004. The majority of educational programmes are provided
in co-operation with other divisions within or outside the University
Medical Center Utrecht. The Center is home to the only Dutch graduate
programme for nursing science. The Center is, among other things,
responsible for the specialist training of medical doctors as general practitioners in a three-year vocational training programme. Notably, a new
training programme for a master’s degree in epidemiology was started in
2004 together with other faculties of Utrecht University. Education for
the benefit of researchers at the Julius Center takes place by means of
participation in recognized graduate schools such as the Netherlands
Institute for Health Sciences (NIHES) (www.nihes.nl), Infection &
Immunity (www.eijkmanschool.org), Psychology and Health (http://
pandh.fss.uu.nl), and ImagO (www.imago.uu.nl). Agreements with the
management of NIHES led to more intensive collaboration on marketing and recruitment of master’s students and a proposal for a joint website for the Master’s in Epidemiology programme. The number of educational programmes is growing each year. This year a new course for
the medical curriculum has been developed (Medical Humanities) and
will be implemented in the curriculum in September 2008. Medical
Humanities stands for an interdisciplinary field in which the ethics,
health law, history and philosophy of medicine, social sciences and art
converge.
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Annual Report 2007
Education at the Julius Center is typically organised by discipline. Each
discipline has its own co-ordinator who tunes the different teaching programmes within that particular discipline. The Center supports training
of lecturers and 2 co-workers of the Julius Center got their SKO and 1
the BKO certificate. In the scheme on the next page the programmes
(original names of the courses) are summarized that are coordinated by
staff-members of the Julius Center. A more detailed description can be
found in the particular chapters.
Education
57
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Annual Report 2007
Nursing Science
Nutritional Science
Medical Humanities
Public Health
General
Practice
Epidemiology
Clinical Epidemiology
for Internists
Clinical Epidemiology
and EBM for professionals
Research Master
Epidemiology
Discipline Overstijgend Onderwijs
Wetenschappelijke vorming II (SUMMA)
START (CRU + SUMMA)
Master Epidemiology
Wetenschappelijke stages (CRU +
Keuze cursus ‘clinical trials’ (CRU)
Architectuur van Klinisch Wetenschappelijk onderzoek (CRU)
Wetenschappelijke stages
(PAO-H)
ning
(SUMMA + CRU)
Klinisch lijnonderwijs (CRU)
Master Nursing Science
Keuzecursus: voeding in de geneeskunde (CRU)
START (CRU + SUMMA)
classes
wetenschappelijk onderzoek
Lezen en beoordelen van (verplegings-)
nen- als buitenland
Geneeskunde en Maatschappij (CRU)
weken), wetenschappelijke stages (12 weken) zowel in bin-
Keuzecursus Forensische geneeskunde
Co-schappen (4 weken), keuzestages (6 weken), BSAS (12
Keuzecursus Diversiteit
BSAS (CRU)
Keuzecursus Zorgmanagement
(CRU)
START (CRU + SUMMA)
TLO (CRU)
Keuzecursus Gezondheidsrecht
(CRU)
Geneeskunde en Maatschappij (CRU)
Oriëntatie geneeskunde (CRU)
CRU)
Wetenschappelijke stages (SUMMA +
Integrated Care Master
wijs voor Huisartsen
Vocational Trai-
Co-assistentschap huisartsgeneeskunde
Patiënten volgprogramma (CRU)
ASAS (SUMMA + CRU)
Post-Academisch Onder-
General Practice
Praktijk van de zorg (SUMMA)
Oriëntatie geneeskunde (CRU)
SUMMA)
Continuous Professional Education
Graduate
Master
Bachelor
General Practice
Introduction
In the Netherlands, General Practice is an important specialisation in
the medical domain. In the basic medical education (bachelor, master’s)
the General Practice staff of the Julius Center participates in various
ongoing educational programmes and provides courses at several levels
in the medical curriculum. Besides these activities there is a vocational
training programme and continuous medical education.
-Bachelor
-Master’s
-Post-Graduate / Vocational training programme
-Continuing Professional Education
The major purpose of all of these courses is to teach students the principles and methods of general practice and for the trainees in the vocational training programme to become a adequate general practitioner,
and for the general practitioner to keep his competencies on a standard
level.
Bachelor
Description
The basic medical education starts generally after secondary school at
the age of 18 at the university medical school. A three year period of
acquisition of knowledge and skills is followed by three years of internships, where people gain their basic medical experience in teaching hospitals and (for 6 weeks) in general practice. During the last decade however in our university the period of practical experience in internships is
partially put forward to the first years of training. That step is motivated
Education
59
by the evidence that theoretical education in combination with practical
experience allows students to construct their own knowledgebase more
efficiently and more efficaciously. One could also say it gives a student
more opportunities for learning within the context of his future work.
Motivation of students and professional behaviour is stimulated when
students are confronted with patient care in an early stage of their education.
The bachelor programme caters to about 900 students.
Course Information
We teach 312 students in every class-year. The department of general
practice is responsible for the introduction course for new medical students. This course lasts for five weeks. In the last two weeks of the course
most students gain experience in clinical practice during a nursing
apprenticeship, whereas a small part of them (24 students) have the
possibility to participate in an observational apprenticeship in general
practice.
Since the educational programmes are problem-oriented and no longer
discipline-oriented our department has no courses on its own. Together
with other clinical disciplines we teach our specific knowledge and skills
to the students.
Courses we contribute to are:
-students following patients programme, first year
-clinical reasoning programme, first year
-students following patients programme, second year
-clinical reasoning programme, second year
-metabolism
-sensory organs, brain and movement
-acute medicine
-patient care in the Netherlands for foreign physicians
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Annual Report 2007
Master’s
CRU
Description
Two trends are visible in the undergraduate teaching, one is early internships and the second is to realize a better link up between the undergraduate and the post graduate teaching to make the sixth year more a
transition year between the undergraduate teaching and the specialization. In the postgraduate teaching we have to realize that these changes
have occurred.
Course Information
General practice contributes to the following courses:
-eye-diseases
-medicine and society
-determinants of disease
-practical electives
-scientific electives
We offer the six week internship in General Practice to 360 students
every year in the second year of the master’s programme.
In the third year of the master’s programme we supervise 40 selected
students during an internship that lasts 12 weeks.
Summa
Description
The department of general practice is responsible for several parts of the
curriculum of the Summa-master’s. In the first and the second year all
students (40 students yearly) are trained in clinical reasoning by GP staff
members. In addition most students gain experience in clinical practice
Education
61
during a nursing apprenticeship in their first year, whereas five students
yearly have the possibility to participate in an observational apprenticeship in general practice. In the third year all students have a six week
internship in general practice, while two or three students are supervised
annually in a longer internship of 12 weeks in their fourth year.
General Practice Vocational Training (Postgraduate)
Description
The postgraduate training is carried out by 8 Institutes for Postgraduate
Training. They have a total of about 1300 trainees. The Julius Center is
home to one of the eight General Practice Vocational Training Courses
in the Netherlands. In Utrecht there are 216 trainees in our programme;
72 trainees a year.
It is a three-year course and consists of two years of training in general
practices and one year in hospitals, health care institutes and nursing
homes. In order to serve the needs of the course, there is close cooperation with 213 general practitioners, 7 peripheral hospitals, 22 nursing
homes and 18 regional institutes for outpatient mental health care. The
trainees attend the department of general practice for reflection and
training one day a week.
Each training institute is linked to departments of general practice of
university medical centres. In Utrecht we are embedded in the Julius
Centre with epidemiologists.
On a national level a close cooperation exists between the training
departments of all participating University centres and the Dutch
College of General Practitioners.
In that perspective a number of products have seen light: for example a
core competency oriented curriculum has been constructed, educational
tools, all kind of assessment tools and ICT management tools are devel62
Annual Report 2007
oped. We have determined the competencies of trainers and teachers ,
and there is a teach the teacher programme a teach the trainer programme and an assessment protocol. Too much to address all these
issues here. A main advantage of this cooperation is the exchange of
experience on a national level: we learn from each other and we are
stimulated to improve our own results. The cooperation in the Julius
Centre is especially relevant to the topic of EBM education.
As already stated the curriculum of GP training is 3 years full time
according to EU agreements. There are however considerable differences
within Europe caused by the different local organisation of health care
and the different historical background of primary care in Europe.
We do recognise and certify previous postgraduate experience in teaching hospitals. That causes in half the cases a mean reduction of the training period of 6 months.
Besides learning and teaching of the medical expertise, it is more and
more important and accepted by the Board of General practitioners to
teach seven competencies.
We are very happy that not only for the training of general practitioners
but also for all specialists these seven competencies (Canmeds skills for
the new millennium) are formulated that will form the basis for the education for the trainees in the different competencies in a competency
oriented curriculum: medical expertise, doctor patient communication,
collaboration, management, social accountability, science and education
and professionalism.
Education
63
In a competency oriented curriculum you need an adequate assessment
programme. On the basis of the assessment the trainee adjusts his or her
individual learning and development plan. In that perspective in
Utrecht, but also at the other departments in the Netherlands, we developed an extensive assessment programme.
At the end of the first year there is a Go/No Go decision. A ‘Go’ means
that the trainee is supposed to be able to complete the whole training
period successfully to become an adequate general practitioner.
Course Information
Each of the three training years has different characteristics. In the first
year the emphasis is on obtaining and sharpening skills in general practice. In the second year, particular attention is paid to the cooperation
between the GP and specialists and training in special skills by doing
internships in hospitals and Regional Institutes for Outpatient Mental
Health Care and Nursing Homes. In the third-year, the acquisition and
integration of in-depth knowledge takes center stage. Every effort is
made to increase the expertise and quality of future GPs. In 2006 we
started with a more competency oriented curriculum.
As a consequence of the health care reform trends of change can be foreseen which are coming up now and will be reality in the near future. As a
teaching department we must be able to accommodate these changes.
Or, even better, as an university department we should be in the frontline of change with experiments and educational reform.
Networks of general practices are coming up momentarily, with franchising formulas and central management.
They tend to organise own facilitating services for groups of GP prac­
tices to gain more efficiency and more competing power.
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Annual Report 2007
Within general practice one can perceive a trend of differentiation
between GP’s and within GP groups. That means that new tasks are
taken up by more or less specialised GP’s within a group in that way
­creating opportunities to distribute tasks between the GP’s. By doing so
one can reach together in cooperation a higher level of care.
That’s why there are possibilities for differentiation in the new curriculum.
Course Titles
-First year: four days of general practice training in medical practice
and one day release course with different topics.
-Second year: internship in emergency department general hospital,
mental health and nursing home.
-Third year: four days of general practice training in medical practice,
differentiation on management/ education/ science/ special interest
like diabetes, asthma, COPD, cardiovascular risk management.
Output 2007
Number of students
In only a few years the capacity has been increased to 216 trainees in
2007.
-Number of students who started their GP training in 2007: 74
-Number of students who finished their GP training in 2007: 71
Advanced Training in General Practice
(Continuing Professional Education)
Description
Post-academic training for general practitioners (Post Academisch
Onderwijs voor Huisartsen, PAOH-Utrecht). The focus is on up-to-date
information for GPs, evidence based and relevant to general practice.
Education
65
Output 2007
80-220 GPs attended each course (with a total of around 1300 GPs)
Evaluation
The courses are evaluated consistently as very good.
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Annual Report 2007
Evaluation
marks
Course Titles (Dutch)
Dermatologie
Sport en beweging
Nierziekten en urologie
Kanker
Zwangerschap en erfelijkheidsvoorlichting
Infectieziekten
Reizigersgeneeskunde
10e Diabetesdag
Kindergeneeskunde
Kinderallergie (EXTRA)
EHBO (EXTRA)
% passed
exam
Course Information
In 2007 the Julius Center organized 9 days (6 accreditation points) and 2
afternoons (PAOH EXTRA, 3 accreditation points) for GPs in the
Netherlands.
Epidemiology
Number
participants
The courses are interactive by using an interactive voting system. All
speakers are experts on their topic.
268
97%
7.0
February – May 2007
40
100%
6.5
Start Block EBM module
6 courses between Aug
2006 – July 2007
250
100%
7.2
EBM DOO
December 14 in 2006
and January 25 in 2007
40
100%
6.5
NIV
15 Feb and 10 Oct 2007
100
100%
6.9
Introduction to
Epidemiology
4 – 15 sep 2006
52
98%
7.4
Study Design
18 Sep. – 6 Oct. 2006
49
94%
7.7
Clinical Epidemiology
16 Oct. – 10 Nov. 2006
44
98%
7.2
Presentation and writing 15 – 17 Jan. 2007
of research proposal
38
97%
7.7
Advanced Diagnostic
Research
5 – 9 March 2007
38
92%
7.9
Prognostic Research
26 – 30 March 2007
49
100%
7.7
Clinical Trials and Drug
Risk Assessment
23 – 27 Apr. 2007
39
95%
6.8
Basics of advanced
mathematical modeling
of infectious diseases
29 May – 1 June 2007
45
98%
7.2
Advanced mathematical
modeling of infectious
diseases
4 – 8 June 2007
20
95%
7.7
Course
AKWO
Course dates
12 courses between Aug
2006 – July 2007
SUMMA
Education
67
Medical Bachelor
AKWO (Architectuur van Klinisch Wetenschappelijk Onderzoek)
-Architecture of Clinical Scientific Research
-Course leader: Maroeska M. Rovers, PhD
Brief Course Description
In modern medicine, physicians ask themselves continuously to what
extent their medical decisions (diagnostic, therapeutic, prediction of
prognosis) are based on solid scientific evidence. This 6-week full time
course will equip medical student with the basic knowledge and skills of
clinical epidemiology.
In order to be able to value and interpret scientific reports, students
will need to acquire their own research experience. During this course
students will learn how scientific knowledge is generated. We give the
students a taste of the various aspects of clinical scientific research by
simulating the entire process of a scientific research project.
They will learn how to define a research question, select the appropriate
study design to answer this question prepare a research protocol, collect
data, and analyze, interpret results, report and present the findings. At
the end of this course students will be able to differentiate between the
different study designs, methods and analytic techniques of etiological,
diagnostic, prognostic and therapeutic research.
Students work in small teaching groups, with practical assignments,
workshops and meet the expert meetings.
This course runs 12 times a year for groups of 25 students. Each time the
course is constructed around a(nother) clinical problem, for example
chest pain or neurological deficits; each year approximately 6 clinical
problems will be discussed. The selection of clinical problems is based
on the frequency of occurrence of the problem and the clinical and
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Annual Report 2007
research expertise of the supervisors. Thereby, although this is not the
main objective of the course, students will improve their knowledge on
the incidence, etiology, diagnosis, prognosis and therapy of the clinical
problem chosen.
Staff Involved
A. Algra, J. Beulens, M.J.M. Bonten, M.L. Bots, K. Fischer, M.I. Geerlings,
C.H. van Gils, Y. van der Graaf, E. Hak, A.W. Hoes, K.G.M. Moons,
P.H.M. Peeters, M.M. Rovers, A.P.E. Sachs, Y.T. van der Schouw, S.S.
Soedamah-Muthu, C.S.P.M. Uiterwaal, Y. Vergouwe, F.L.J. Visseren, and
our PhD students.
Medical Master’s of Science
Evidence Based Medicine
Course leader G.J.M.G. van der Heijden
START Block and Return Days (in Dutch ‘Startblok en Terugkomdagen’)
Brief Description of Course Content
In modern medicine, physicians ask themselves continuously to what
extent their medical decisions (diagnostic, therapeutic, prediction of
prognosis) are based on solid scientific evidence. This 6-week half time
course at the final 6th year of medical school will equip medical student
with the principles of evidence based medicine and applied knowledge
and skills of medical evidence management. This course builds on the
skills and knowledge acquired during the AKWO course at the 3rd year
of medical school.
In order to be able to apply best available evidence in patient care, students will need to acquire their own experience with medical evidence
Education
69
management. During this course students will learn how to write a case
report: a 1200 words comprehensive summary best available evidence
on questions concerning the management of a particular patient. These
are focused on a foreground question, i.e. an applied problem of diagnostic, prognostic and therapeutic patient management rather than on a
theoretical or conceptual scientific background problem.
For this we learn them to adequately translate the problem in an adequately phrased search question, efficiently retrieve and select the best
available evidence, tabulate and translate it in terms of clinical patient
management.
We use of small teaching groups, with practical assignments, workshops
and meet the expert meetings.
During their subsequent 24 weeks internship at the clinical ward students get the assignment to write the 3 case reports per couple. Each student reviews and grades 6 case reports of other students.
Staff Involved
M.L. Bots, K. Fischer, K.G.M. Moons, M.M. Rovers, A.P.E. Sachs,
S.S. Soedamah-Muthu, E.M. Monninkhof, and our PhD students.
Scientific Education 2 (in Dutch: ‘Wetenschappelijke Vorming)
During this course, students of the Selective Utrecht Medical Master’s
(SUMMA) Programme learn will learn in plenary lectures and moder­
ated small student groups about the theory of risk, and the epidemio­
logic design of diagnostic, prognostic, and experimental research.
At the end of this course students will be able to differentiate between
the different study designs, methods and analytic techniques of etiological, diagnostic, prognostic and therapeutic research, and have learned
how to value and interpret scientific reports, as well as how to define a
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Annual Report 2007
research question, select the appropriate study design to answer this
question prepare a research protocol.
This course runs once a year for groups of 40 students.
Staff Involved
Cuno Uiterwaal, Yolanda van der Graaf
Biomedical Master’s of Sciences
Epidemiology Research Master’s Programme
Brief Description of Programme Content
The Utrecht University Graduate School of Life Sciences offers two
Epidemiology Master’s programmes which are organised by research
groups at UMC Utrecht (Julius Center) and Utrecht University (IRAS,
Veterinary Epidemiology, and Pharmaco-epidemiology):
-a 2-year regular Research Master’s programme; this programme is
aimed at students holding a Bachelor of Science degree in Biomedical
Sciences, (Veterinary) Medicine or Pharmaceutical Sciences.
-an 18-month postgraduate Research Master’s programme; this
programme is aimed at professionals, e.g. PhD students or health
professionals involved in clinical research, holding a Master’s of
Science degree in Life Sciences or (Bio-)Medical Sciences, for example
in Medicine (MD), Pharmaceutical Sciences (PharmD).
In close collaboration with these Epidemiology Prestige Master’s
Epidemiology programmes, Utrecht University offers a postgraduate
research master’s programme in Veterinary Epidemiology and
Economics for professionals holding a Doctoral degree in Veterinarian
Medicine (DVM).
Education
71
The two main components of the programmes are:
-comprehensive theoretical education in the principles and methods of
epidemiological research (over 6 months of courses),
-a practical research project in which the theory can be applied. This
research project is finished by the writing of a scientific paper, and an
oral presentation.
These 2 programme components provide students with extensive
knowledge and practical skills in patient-oriented research design,
implementation, quantitative analysis and its application to human or
veterinary medicine and public health. The knowledge and skills gained
form a solid basis for health research and disease control programmes,
including application in developing countries.
The programmes provide the possibility for specialisation in Clinical
Epidemiology, Epidemiology of Infectious Diseases, Pharmaco-epidemiology, Environmental and Occupational Epidemiology, and Veterinary
Epidemiology (as from 2008 labeled: Epidemiology of Animal Diseases).
In December 2005 Utrecht University awarded the Epidemiology master’s programme with the exclusive label ‘Prestige Master’s’. For more
information go to www.msc-epidemiology.eu.
Staff Involved
Programme coordination: M. Kluijtmans, J.E. Brussee,
Programme committee: D.E. Grobbee (Chair), A.W. Hoes, M.J.M.
Bonten, Y.T. van der Schouw, K.G.M. Moons, G.J.M.G. van der Heijden
Course leaders, teaching staff: A. Algra, M.L. Bots, E. Buskens, J.J.M. van
Delden, M. van den Donk, K. Fischer, M.I. Geerlings, C.H. van Gils,
Y. van der Graaf, E. Hak, E.M. Monninkhof, P.A.H. van Noord, P.H.M.
Peeters, M.M. Rovers, S.S. Soedamah-Muthu, I. van der Tweel, C.S.P.M.
Uiterwaal, Y. Vergouwe, PhD
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Annual Report 2007
Continuing Professional Education
Clinical Epidemiology
Course leader: M.L Bots
Brief Description of Programme Content
This 2-day course on the principles of Epidemiology and Evidence Based
Medicine for members of the Dutch Society of Internal Medicine (NIV),
in particular for residents and registrars, includes plenary lectures on
methods of applied research and evidence based medicine and small
moderated student groups.
At the end of this course participants are familiar with the principles of
epidemiological study design for diagnostic, prognostic and intervention
research, are able to critically appraise clinical medical research papers
and clinical guidelines.
Staff Involved
D.E. Grobbee, A.W. Hoes, A. Algra, M.L. Bots, M.I. Geerlings, C.H. van
Gils, Prof. Y. van der Graaf, P.H.M. Peeters, C.S.P.M. Uiterwaal
Evidence Based Medicine
(Discipline Overstijgend Onderwijs)
Brief Description of Programme Content
This 2-day course on the principles of Epidemiology and Evidence Based
Medicine for clerks and residents at UMC Utrecht and collaborating
teaching hospitals, includes plenary lectures on methods of applied
research and evidence based medicine, small moderated student groups,
with additional lectures external speakers for the plenary sessions.
At the end of this course participants are familiar with the principles of
epidemiological study design for etiologic, diagnostic, prognostic and
Education
73
intervention research, are able to coherently formulate a clinical question, search and critical appraisal clinical research papers, clearly summarise available evidence and critically consume clinical guidelines.
Course
Target group
Teaching staff
UNDERGRADUATE
6 week introductory
course in applied clinical
epidemiology
400 3rd year medical
students of University
of Malaya and
University of Indonesia
per year
Staff from the
University Medical
Centre Utrecht and
University of Oxford
(first teaching, then
supervisory).
Staff from University of
Malaya and University
of Indonesia (teaching).
PhD fellows (assisting
in practicum)
POSTGRADUATE
Basic course clinical
epidemiology and
evidence based
medicine
Advanced courses
clinical epidemiology
and evidence based
medicine
480 Medical doctors
(practicing doctors,
post graduate
researchers,
management staff) of
the University of
Malaya and University
of Indonesia and
affiliated hospitals.
Healthcare policy
makers of Ministries of
Health.
Staff from the
University Medical
Centre Utrecht and
University of Oxford
(first teaching, then
supervisory).
Staff from University of
Malaya and University
of Indonesia (teaching).
Staff Involved
Marie-Louise Bartelink, Geert van der Heijden, Maroeska Rovers,
Peter Jacobs, Frank Visseren, Kathelijn Fischer, Evelyn Monninkhof
Clinical Epidemiology & Evidence Based Medicine in Asia
November 1, 2007 was the official start of the EU financed AsiaLink
project. This project, initiated by the Julius Center is a collaboration
between the University Hospital Cipto Mangunkusomo in Jakarta
(Indonesia), the University of Malaya in Kuala Lumpur (Malaysia), the
University of Oxford (UK) and the University Medical Centre Utrecht
(the Netherlands) to establish the necessary platform for a durable
improvement in clinical epidemiological teaching and research in
Indonesia and Malaysia.
The specific actions planned include:
1 Teaching Mission
Aim: to establish common and sustainable knowledge and capacities
in the participating centres in evidence based medicine and clinical
epidemiology by organizing teaching missions aimed at defined
target groups at undergraduate and postgraduate level.
2 PhD Fellowships
Aim: To enable the most talented young medical doctors of
University of Malaya and Cipto Mangunkusumo Hospital Indonesia
to deepen their knowledge and expertise in specialized areas of
clinical epidemiology on an international level.
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Annual Report 2007
Ten PhD fellows (six from each country) will be recruited (six in year
one and six in year two). The PhD fellows will be supported and
mentored by expert scientists of the University of Oxford and the
University Medical Centre Utrecht. In addition, they will be receiving
supervised teaching experience by teaching graduate and
postgraduate students.
Education
75
3Development of Clinical Epidemiology & Evidence Based
Medicine Units
Aim: to develop regional collaborative (support) units at the
premises of Malaya University and Cipto Mangunkusomo Hospital
to assure continuity of the educational programmes beyond the
duration of the programme. These units will be coordinating,
facilitating and supporting future structural collaboration for
educational and research projects between Asia and Europe in
Clinical Epidemiology and Evidence Based Medicine.
The following activities took place in 2007:
- Project launch
In November 2007, AsiaLink Clinical Epidemiology and Evidence
Based Medicine (CE & EBM) was officially launched at the University
of Malaya (Kuala Lumpur), in the presence of University and
Hospital officials, European and Malaysian AsiaLink partners,
students and press.
- Postgraduate courses
In the same period, a first advanced postgraduate course on
Diagnostic Research at the University of Malaya (Kuala Lumpur) was
offered, which was attended by 76 participants.
- Implementation of undergraduate module
At the University of Malaya (Kuala Lumpur) and the University of
Indonesia (Jakarta), we are in the process of, and making good
progress with, the implementation of the undergraduate module. All
relevant officials (Deans, Vice-Deans, Educational Managers etc.) are
on board and have agreed to have implemented the module by July
2009.
- PhD fellowships
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Annual Report 2007
A ‘Call for PhD fellowships’ has been circulated and announced on
our website. In November 2007 in Jakarta, Dutch Professors, in close
collaboration with their Indonesian counterparts, have selected two
PhD candidates. In Kuala Lumpur, two candidates will be selected in
April 2008. These fellows will start their training in the Netherlands
in September 2008.
- Clinical Epidemiology Units
We have hired two local co-ordinators, who will be manning the
Clinical Epidemiology Units in Kuala Lumpur and Jakarta. In both
cities, accommodation has been made available by the local
institutions.
- Communication / Visibility
We have built a project website, www.asialink-ce.org, and sent out
our first newsletter (ALliance).
Education
77
Public Health
On different levels throughout the whole medical educational programme, different courses related to the field of Public Health are being
offered. The educational programme of Public Health defines as main
focus the principles and methods of healthcare research, structure, quality, finance en functioning of healthcare systems, with a focus on Social
Medicine and Public Health interventions. When it comes to these matters there is a constant centre of attention around the updating of the
educational material within the Public Health division.
Bachelor
In the first year of the bachelor phase, the course ‘Orientation to
Medicine’ (‘Orientatie Geneeskunde’) is offered. In this course the main
outlines of the organization of healthcare are the focus point. An internship in a nursing home or a care institution of a different kind is part of
this course. Last year the average result of the evaluation by students
was a 7.
-‘Diversity in prevention, illness and care’ (‘Diversiteit in preventie,
ziekte en zorg’). This course is set up to create and stimulate the
awareness of the presence and influence of diversity in the medical
profession. The average result of last year was a 7.2.
-‘Forensic Medicine’ (‘Forensische geneeskunde’). This course is being
developed.
Master’s
In year 5 the course ‘Medicine and Society’ is offered. Matters that are
being discussed within this course are aspects of health and healthcare,
the grey area between curative forces and society. Connected to this
course are obligatory internships in social medicine for a period of 4
weeks. Past year the average result was a 6.9.
In year 5 the course ‘TLO’ is also offered. In this course themes like avian
influenza, prostate cancer screening and prevention projects in large cities were being studied. This course had an average result of 6.4. This last
year a different approach is chosen with a new theme: patient safety.
In the second year 4 optional courses of 5 weeks each are offered,
­namely:
-‘Disease Management’ (‘Zorgmanagement’). The main objectives of
this course are the improvement of competence on the area of
knowledge of care management, co-operating within a
multidisciplinary context and the communication with different kinds
of professionals. The average result of this course last year was an 8.
-‘Law and Medicine’ (‘Gezondheidsrecht’). This course is centred
around the legal and regulatory framework of the Dutch health care
system, with a focus on the professional competence of doctors. The
average result of last year was a 8.1.
Year 6 has it’s focus points on the decision making processes in healthcare in emergency situations, and the organization, quality and finance
of healthcare.
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Annual Report 2007
Optional internships of 6 weeks are part of the possibilities in the 4th,
5th and 6th year. In year 6 it is possible to do a BSAS, a scientific internship or an educational internship within the division of Public Health.
It is possible to do these internships and optional internships abroad.
For these matters one should contact R.W. Haneveld, head of Public
Health Education. Due to computer problems there are no evaluation
records on the different internships available.
Education
79
Postgraduate
The division post graduate education provides additional and refresher
courses like symposia and conferences for graduated doctors. All of the
courses are accredited. Turn to Prof. A.J.P. Schrijvers via Mrs. G.M.C.
Hageman, Manager Post Graduate Education for additional information. Phone: +31 88 75 530 10
Continuing Professional Education
In cooperation with many foreign and non-foreign guest teachers, the
division Public health provides additional courses for professionals in
healthcare, set up in the form of conferences, courses, workshops and
study trips. For an overview on the different activities go via ‘nascholing’
to www.integratedcare.nl.
Contact
Head of Public Health Education
R.W. Haneveld, MD, PHS, MPH
E-mail: R.W.Haneveld@umcutrecht.nl
Phone: +31 88 75 593 73
Secretariat
Mrs. M.C. van Straaten
Phone: +31 88 75 593 06
Medical Humanities
Overview
Medical humanities is a term which we use for a interdisciplinary field in
which the humanities, sociology and arts come together. The humanities
are medical ethics, health law history of medicine, and philosophy of
medicine. Sociology is medical anthropology and medical sociology and
with arts we mean literature, theatre and movies.
The aim of this course is to help the student become a better physician.
By providing insight into the human condition, complementary to his
or her biomedical knowledge.
By providing a better understanding of the responsibilities and duties
physicians have for their patients and society.
By showing that the art of medicine is performed within a cultural and
societal context which is characterized by diversity and by showing that
this context also shapes the experience of being ill and the way medicine
is performed.
By further developing the student’s competence for observing, analyzing,
empathy and self-reflection.
Bachelor
In the third year of the curriculum CRU2006, starting in September
2008, two courses of four weeks each will be devoted to Medical
Humanities. All students will have to take both courses. Since this course
has not been given yet, evaluations cannot be given at this moment.
Master’s
In the master’s phase of CRU2006 no integrated courses in medical
humanities are given. Nonetheless, some of the disciplines of medical
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Annual Report 2007
Education
81
humanities, especially health law and medical ethics will contribute to
courses, e.g. the starting course in the sixth year.
Postgraduate
Not applicable.
Continuing Professional Education
Not applicable.
Nursing Science
Overview
In 2000, a Master’s of Science degree for the Health Sciences programme
was established at Utrecht University (UU). Nursing Science was the first
major field of study to be offered within the Health Sciences programme. Physiotherapy Science was added as a second major field of
study in 2002 and Speech Therapy Science as the third field in 2003.
However, a new curriculum for the Health Sciences programme was
necessary in order to comply with the European regulations for university education and to conform to the international Bachelor-Master’s
structure in higher education. This resulted in the development of a two
year part-time master’s programme (60 ects) for graduates of a BSc-university degree programme or a premaster’s programme (see description
Bachelor below). The MSc programme in Nursing Science started in
September 2005. In July 2006 accreditation of the master’s programme
was given by the External Accreditation Committee (EAC) - a committee appointed by the Ministry of Education and responsible for accrediting all university programmes. The accreditation is valid till July 2012.
The Department of Nursing Science within the Julius Center for Health
Sciences and Primary Care is responsible for the development and coordination of the Nursing Science field of study.
Bachelor
Description
At this time, Utrecht University does not offer a bachelor programme
Health Sciences. Instead, a one year part-time premaster’s programme
(30 ects) was developed for graduates of a non-university bachelor programme. This programme enables students to qualify for admission to a
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Annual Report 2007
Education
83
university level master’s programme. A certificate is awarded upon successful completion of the premaster’s programme.
Courses
EC
Project and Academic Skills
7.5
Philosophy, Science and Ethics
7.5
Research Methods
7.5
Statistics
7.5
All coursework
30
Output Premaster’s 2007
Started: 72 new students in addition to 6 already enrolled
Completed with success: 42 students
Evaluation
The average grade (on a 0-10 scale) of the students for the premaster’s
programme is 7.35
Master’s
Description
The MSc in Nursing Science is a two year part time programme offered
by Utrecht University. Students are educated and trained in four roles:
academic professional, researcher, innovator and educator/coach.
Consequently, the student is able to combine the world of science with
that of nursing practice and to contribute to the development and scientific foundation of nursing.
Annual Report 2007
Courses
EC
Nursing innovation policy
6.5
Innovation development and implementation
6.5
Advanced Statistics
Premaster’s Nursing Science Programme Information
84
MSc Nursing Science Programme Information
2
Systematic Literature Review
7.5
Science and Nursing Practice
6.5
Elective course
6
Master’s thesis: proposal and preparation
8
Master’s thesis: conduct and reporting
15
Portfolio
2
All coursework
60
For more detailed information (in Dutch) concerning the MSc programme, check the website of Nursing Science:
www.umcutrecht.nl/verplegingswetenschap.
Output MSc Nursing 2007
Started: 50 new students in addition to 40 already enrolled
Graduated: 55 master’s students.
Evaluation
The average grade (on a 0-10 scale) of the students in the master’s
­programme is 7.38.
Postgraduate
Not applicable.
Education
85
Continuing Professional Education
Description
Nutritional Science
In collaboration with the Education Center of the University Medical
Center Utrecht a 2.5-day course is offered annually for nurses who want
to develop basic competencies in reading and critically appraising scientific research (particularly in nursing). The content of the course focuses
on research methods and concepts, searching in scientific databases such
as PubMed, reading and appraising quantitative and qualitative research,
and finally the use of research findings and evidence in practice.
Overview
There are many misconceptions about the effect of nutrition on health.
Most consumers, patients and doctors are uncertain whether a prudent
diet can prevent diseases and whether clinical nutrition can help cure
disease. The Division of Nutritional Sciences strives to enhance the professional knowledge and the understanding of nutritional problems,
depletion and metabolic needs in relation to disease. Our target consists
of medical students because nutrition education is fragmentary in their
medical courses. We teach them to acknowledge nutritional problems
and malnutrition, and to decide which patients should be referred to a
dietician.
The facultative course Nutrition and Medicine (‘Voeding in de
Geneeskunde’) takes a collaborative and interdisciplinary approach to
nutritional problems in the clinical setting. An evidence-based approach
is encouraged.
Output 2007
12 participants.
Evaluation
The course was rated with an average score of 7.5 (on a 0-10 scale).
Bachelor
GNK0708 3 – facultative course ‘Voeding in de Geneeskunde’: twice a
year, 4-week course for 3rd year bachelors. The course consists of (guest)
lectures and group work. Topics include:
-Methodology: how to read scientific papers about nutrition and health
-Practice: how to assess nutritional status (malnutrition)
-Prevention of chronic diseases
-Therapeutic diets
-Nutritional supplements and functional foods
-Management of treatment side effects
-Management of specialized feeding regimens like tube feedings
-The effect of life style modification
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Annual Report 2007
Education
87
The course is assessed by means of an individual multiple choice test
and group poster presentations about a concise research project. In
2007, 47 students took the course of whom 46 passed their examinations. The course was graded 6,4 (March) and 7,1 (October). The course
will be changed into a 5-weeks course within the CRU2006 programme.
Master’s
Not applicable.
Postgraduate
Not applicable.
Continuing Professional Education
Not applicable.
88
Annual Report 2007
Education
89
Patient Care
‘Leidsche Rijn offers us a unique opportunity to
deliver academic and integrated primary health
care. The challenge is how to do that in a real client
centered way. In daily practice this is much more
difficult than theory suggests.’
(Rob van Damme)
Patient care
91
Nutritional Sciences and Dietetics
Nutritional Sciences and Dietetics are two groups which form one
­section. Education and research are the core activities of Nutritional
Sciences while the Dietetics core activity is providing patient care at
UMC Utrecht and at rehabilitation center ‘De Hoogstraat’. The section
Dietetics is nationwide leading in evidence based dietetics and standardized processes for dietetics professionals.
Electronic Dietetics Patient File
The implementation of an electronic dietetics patient file was the most
important project in 2007. This file will replace all paper files. All new
patients and most of the chronic patients have been imported in the new
system. All personnel were trained to work with the file. During 2007 the
section developed several improvements to the system and files.
Connections with other electronic files in the UMC Utrecht were made.
Dietetics is the first section within UMC Utrecht that is working with
the electronic patient file. The implementation was successful. In the
near future the electronic files offer more and new possibilities for
research.
Evidence-based Guidelines
The development of evidence-based guidelines and product descriptions
(short practical guidelines) is still making progress. As always several
guidelines and product descriptions provided topics for concise (student) projects, such as cystic fibrosis related diabetes, growth and lung
capacity, iodine restricted diet, patient satisfaction in food allergy treatment and treatment during radiotherapy, etc. One student project, on
the relationship between sulphur intake and exacerbations of Colitis
Patient Care
93
Ulcerosa, won 3 awards; the NVVL award, Novartis dietetics award and
the prof. dr. W. van Mechelen award.
Educational and Scientific Contributions
In 2007 21 students from Wageningen University and from the various
Dietetics Academies performed student projects and worked on practical skills.
The dieticians gave several lectures, workshops and poster presentations
for health care professionals on topics such as Cystic Fibrosis related
Diabetes, ketogenic diet in the Netherlands and other European countries. A 5-week course on nutrition was provided 7 times to food service
assistants nutrition aids in the hospital. Education on several subjects
was provided to several specialist nursing groups, the nursing training
school in Utrecht and dieticians. The section hosted a TODU workshop
on regional cooperation workshop and the 3-yearly gathering of all
Dutch academic hospital dieticians. The dietetic section co-operated in
the facultative course on Nutrition and Medicine.
A few scientific articles were published and several articles and book
chapters are in progress.
Training was provided to the dieticians in the form of external courses,
meetings, and conferences (30 individual activities and 4 group activities
for all dieticians). These activities took place in the Netherlands and
other European countries.
External (International, National and Regional) Projects
The Dietetics section contributed to several external projects. The most
important are:
-The CBO guidelines ‘Peri-operative nutrition’ and ‘Cystic Fibrosis’
were finished. Guideline implementation is in progress.
94
Annual Report 2007
-The national project ‘Ketogenic nutrition guidelines’, including
evidence-based guidelines.
-Chairing and vice-chairing a regional oncology group
-Chairing the national academic dieticians working groups
-Rehabilitation Centre ‘De Hoogstraat’ policy plan , due to the renewed
co-operation goals on development and care provided by dieticians
were set clear
-Member scientific advisory committee of the PKU association
Besides these projects, our staff participated in a wide range of (national) consultation groups.
Internal Projects
Within the UMC Utrecht, the Dietetics sections participated in the following internal projects and work groups:
-hosting the UMC Utrecht Clinical Nutrition Advice Board, this enables
us to discuss nutrition problems and new insights in dietetics in a
broader clinical context. Advice on ‘screening malnutrition’, and
‘Weight plan’ was given. The tube feeding plan and UMC Utrecht food
policy plan are forthcoming.
-indicator malnutrition, delivering figures to the board of directors
-development of a website on PKU in children
-‘Better eating’ project in the Wilhelmina Children’s Hospital
-HOOP study (evidence-based treatment for obese patients)
-participation in clinical multicenter studies (ALS study, propatria)
-introduction of a new tube feedings system
-participation in a hospital food distribution project
Patient Care
95
Dieticians participated besides these projects in several internal multidisciplinary groups to develop, improve and implement evidence-based
and best practice guidelines
Academic primary care
One of the ambitions of the Julius Center is to create an academic
environment in primary care, in which research and medical education are
Personnel
In 2007 no personnel left the section. There were no vacancies. There
was 1 formal complaint.
combined with high quality, innovative patient care. To materialize this
ambition the Julius Center joined in the development of the primary health
facilities in Leidsche Rijn, the VINEX area of Utrecht, and took over management responsibility of the health centers in 2002. After a period of sta-
Care provided by the Dietetics section in 2007
bilization and development the five – of what are presently called - Julius
1st visit
Follow-up visits
DME*
Outpatients
592
1904
3704
Hospitalized
768
1770
2958
No-show
62
190
Team 1
development.
In 2007 an ambitious academic development plan was written, in which the
key features of academic patient care and the required infrastructure and
time frame to develop an integrated research/education/patient care environment are described in detail. The process will require close cooperation
Team 2
Outpatients
653
2091
2668
Hospitalized
1265
4387
6102
23
51
No-show
Health Centers are now ready for the next phase in their academic
with other primary care partners, hospital colleagues, patients and other
stakeholders.
This development plan, which covers a time period of 5 years, was discussed
with the academic staff and the professionals involved, and adopted by the
management team of the Julius Center end of 2007.
Team 3
Outpatients
996
3452
5764
As a result in 2008 the first phase of this academic development in the
Hospitalized
406
712
1752
Julius Health Centers will be implemented, starting off with the assignment
9
49
No-show
and training of academic staff for four different clinical fields (cardiovascular disease, COPD, mental health and diabetes) as well as for education and
Rehabilitation centre
‘De Hoogstraat’
No-show
164
438
1
1
610
research. The academic patient care programmes that they will develop will
be integrated in daily clinical care in 2008/2009. In 2009 and 2010 the programme will be extended to eight other clinical fields, resulting in full
DME *= 30-minute time units
implementation of the academic infrastructure in 2012.
96
Annual Report 2007
Patient Care
97
Julius Center Health Care Leidsche Rijn
As of January 2004, the Julius Center has been hosting a network for
academic patient care, located in the newly developed Utrecht district of
‘Leidsche Rijn’. In the next few years, Leidsche Rijn will expand to a large
suburban area, with approximately 80,000 inhabitants. Six health centers
will provide general practice services, physiotherapy, mental health care,
mother and child health services, pharmacies and social workers. In the
underlying health care concept for Leidsche Rijn, these curative services
are closely related to preventive, social and educational activities in the
area.
This concept is being developed together with municipal health authorities, the University Medical Center, the Mesos hospital and the regional
general practitioners’ organization. The new Mesos hospital will be built
in the center of Leidsche Rijn, offering excellent opportunities for continuity of care and cooperation between general practitioners and consultants (secondary care specialists).
Five health centers were operating in 2007: Parkwijk, which offers health
care services for 10,000 inhabitants; Veldhuizen, with 9,000 listed
patients; Terwijde, with 4,500 registered patients and rapidly expanding;
Vleuterweide, which began in March 2006 in a highly competitive environment. At the end of 2007, Vleuterweide had approximately 1,600 listed patients. Health Center number five: ’t Zand, started in September
2007. The centers offer primary medical care (19 general practitioners,
10.4 full-time equivalencies), physiotherapy (10 physiotherapists,
approximately 7 fte), and additional dietary services, obstetrics, social
work, pharmacy etc. GP’s, assistants and nurses provide medical services
that cover the full spectrum of family medicine, with curative care,
98
Annual Report 2007
chronic disease management for hypertension, diabetes and lung disease
and preventive services involving e.g. cardiovascular disease. The Julius
Center directs the health centers’ management.
The next few years another center will be developed in the Leidsche
Rijn’s Central Zone district. Health care services for new inhabitants in
those areas will be provided in the meantime by the existing health centers nearby.
The Leidsche Rijn Network offers an excellent opportunity for the Julius
Center to fulfill its ambition of providing academic health care services
in primary care. This involves high quality patient care, closely inte­
grated with (vocational) training and research. In order to facilitate this,
training facilities will be incorporated into the health centers at Leidsche
Rijn, enabling on-location training of medical students, general practitioners and other health care professionals. Electronic recording of all
aspects of medical care as well as dedicated support staff will provide the
basis for an excellent research environment in the Leidsche Rijn health
centers. Most new inhabitants of Leidsche Rijn are already participating
in the Leidsche Rijn Health project (LRGP), which records their basic
health characteristics and offers instant medical assessments. In future
this health profile will be related to updated primary medical care data
at the health centers. Medical follow-up of the Leidsche Rijn population
combined with academic research will enable us to develop evidencebased multidisciplinary patient-centered health care programmes.
Patient Care
99
Unit Health Care Innovations
In February 2007 the Board of Trustees of the UMC Utrecht and the
management team of the Julius Center founded the Unit Health Care
Innovations. Mission is to evaluate organizational innovations, to design
instruments to work in innovations and to disseminate knowledge by
courses, congresses and lectures. The Unit is strongly involved with public health education for the medical students of the UMC Utrecht.
Leader of the unit is Guus Schrijvers, professor of public health. The
unit is positioned within the Julius Center.
The focus of the unit is the study of 1. integrated care and disease management and 2. emergency services. The first theme consists of three sub
themes: a. the epidemiology of chronic care b. the evaluation of innovative interventions and c. the validation of assessment instruments and
procedures to select patients with a chronic condition for early interventions. The theme emergency services has three comparable sub themes:
a. the epidemiology of emergency services provided by GP cooperatives,
emergency departments and ambulance services b. evaluation of innovative emergency interventions and c. validation of assessment instruments and procedures to triage patient with acute needs.
In 2007 the unit worked with 17 fte professional staff. They profiled
themselves on the two mentioned themes. Six research grants were
acquired from scientific funds, social funds, and Ministry of health,
social insurance agencies and health care providers. Eight congress and
four courses took place. Seven scientific publications and may reports
were published. Often, the group was asked to give guest lectures on
­scientific and professional congresses. In 2007 the Unit had a positive
financial result.
100 Annual Report 2007
Patient Care 101
Operational Support
‘My taste is simple: I am satisfied with the best.’
(Thijs Bekkers)
Operational support 103
Management Support
The Julius Center’s core activities of research, education and patient care
are supported by a number of services. Management is supported by a
central finance department, a personnel & organization (P&O) department and an ICT department. The finance department handles all contracts and other financial matters. The Julius Center is highly dependant
on external funding, such as the European Counsel funds or Dutch
research funds, such as ZonMw. Because the administration of these
funds is very complex, the center devoted much attention in 2007 to
professionalization and staff development. This professionalization takes
shape in a renewed planning and control cycle which makes it possible
to manage all financial aspects of the organization. Keyword in this
planning is ‘prognostication’. The P&O department deals with management development, vacancies and all procedural matters involving
employment. The ICT Department is responsible for the development
and maintenance of an infrastructure that supports both office automation and scientific research. It provides user support and Internet development services. The Julius Center website was renewed and updated in
2007. The ICT Department is certified by KEMA (ISO 9001:2000).
Operational Support 105
Clinical Trial Services Unit / Research Services
Research Services is available for internal (Julius Center) and external
sponsors. External sponsors can be other divisions of the UMC Utrecht
or pharmaceutical companies.
Our services include
-Project Management including the organization, conduct and
monitoring of clinical trials from initial design to final publication
-Clinical trial co-ordination
-Site monitoring
-Site management
-Endpoint adjudication management
-Adverse event reporting
-Clinical Trial Monitoring of mono- and multi-center trials based in
The Netherlands and other European countries
-Research Clinic: an out-patient research center fully equipped with
state of the art clinical and diagnostic facilities for carrying out clinical
trials
-Vascular Imaging Center: a center of expertise in vascular ultrasound
imaging and retinal vascular measurements
About 60 persons are working for Research Services, including 10 CRA’s
home-based in other European countries. They are involved in about 40
different projects.
The CTSU has been certified according to ISO 9001:2000 since January
2005.
106 Annual Report 2007
The Julius Center is responsible for the Quality Assurance System for
clinical drug trials performed in the UMC Utrecht. Activities include
compulsory quality intake check before starting the study, helpdesk service for questions regarding quality issues, training and audits. Since its
inception in July 2006 100 intakes were performed within 18 months.
The 1-year evaluation showed positive feedback from investigators and
in general improvement in quality consciousness.
In 2007:
-The name CTSU (Clinical Trial Services Unit) was introduced for
external communication. A brochure was developed with fact sheets
covering the services of the CTSU for both Research Services and Data
Management.
-Within the Academic Alliance for Clinical Trials (AACT) the first
international study was acquired.
-Together with scientists of the Julius Center and the Wilhelmina
Children’s Hospital, several vaccination studies were performed. For
this type of research, specialized logistical knowledge is required.
-Within the UMC Utrecht Research Services is responsible for
monitoring of about 40 investigator-driven studies.
-At the research clinic, we were involved in 11 studies. Seven of them
were new (drug) intervention studies, among which a complicated
phase II study.
-After successful completion of two large studies at the Vascular
Imaging Center, we could not realize immediate continuation of the
activities and staff had to decrease accordingly.
-Fifteen multicenter studies were managed and monitored by Research
Services. These studies were performed in up to 16 European
countries.
Operational Support 107
Data Management
Data Management provides a technical infrastructure for the collection,
processing and analysis of epidemiological data. The department provides these services for the Julius Center’s research, but also for other
UMC Utrecht divisions, as well as external parties.
implementing Accolade. The project management is carried out by Data
Management and the CTSU.
The Data management department consists of 13.3 FTE’s (15 employees
in absolute numbers), it has been certified according to ISO 9001:2000
since January 2005.
This year Data Management participated in about 90 studies. These
studies include 21 new ones and eight cohorts (pertaining to mental
health care, oncology and general practice). There were 30 projects were
closed in 2007, at the end of the year the department had 10 prospects.
In 2006 the department successfully implemented a web-based research
system (Research Online Platform) in collaboration with Mediportaal.
The system has been put to use for the first time for GRACE, the first
pan-European primary care research network focusing on the challenge
of treating respiratory tract infections in an era of emerging antibiotic
resistance. In 2007 new projects have been implemented on the platform. The major projects are summarized: DESC (Dexamethason usage
in heart surgery), MOSAR, an EU-funded research programme pertaining to antimicrobial resistance of bacteria responsible for major and
emerging nosocomial infections in hospitals and the Leidsche Rijn
Health care Project.
In 2007 the implementation of the ‘Accolade’ application has started,
which aims to provide management information in the context of the
activities of Quality Assurance System for clinical drug trials. The ambition is to identify all clinical trials in the UMCU as a whole. The
Division DIGD is the first that participates in the project and is now
108 Annual Report 2007
Operational Support 109
Personnel and Finances
‘Working with pleasure, active aging.’
(Coby Molenaar)
Personnel and finances 111
Personnel, Figures (2007-12-31)
Scientific
Support
Care
Total
Male
79
31
2
112
Female
143
67
29
239
TOTAL
222
98
31
351
Male
51.46
27.51
1.67
80.63
Female
97.06
52.97
21.87
171.91
TOTAL
148.52
80.48
23.54
252.53
Male
0.65
0.89
0.83
0.72
Female
0.68
0.79
0.75
0.72
TOTAL
0.67
0.82
0.76
0.72
Absolute numbers
FTE
Average FTE
Personnel and Finances 113
Personnel, Listing 2007
CTSU
AAA Huisman-Bak
AC Krediet
AMH Suiker
CAJ Tims-Polderman
CCW Brugman
CGEM Groot
CTM Nollen
DB Mooiweer-Boogaerdt
EAM Ram
EM Hertogh
GB van Hemert
GP Makhanlal
I Noorman
IE Zwartsenberg-Kowal
JA Zuidema
JJ van de Brink
JWM van Eck
KE Menninga
L Romkes-van Urk
LD Izeboud
M Bolkenbaas
M Verblaauw
MCT Ehrencron
MJ van der Meer-Poelwijk
MTA van Beijnen
ON van Hall
PH Barkel
114 Annual Report 2007
S Ouchan
TC van der Weerd
WS Heddema
AB Marks
AM Bos
BWPM Sies
CBGH van de Pas
CEA Tacke
CH van Everdingen
DA Rozie-Maalderink
EA Wijnia-Lemstra
EM Bollaert-Vendrig
G Haars
GEPM Meijers
H Wisse
I Vissers
IEM Sikking
JAG Stooker-Brouwer
JJM Stern-van den Heuvel
K Koppenol
KM Muller-Nijssen
L van der Vlist
LM Zwart
M de Leeuw
MC Hafkamp
MHGH Wildenborg
MJG Scholten
MW Kuiper
P Holleman
RCM Wilken
Datamanagement
AC Geerts
BJ Slotboom
EHJ Spithoven-van Leeuwen
J Zwerver
JW Maaskant
ML van den Haak-van Mourik
NPA Zuithoff
RB van Petersen
S Brinkman
TC Loffeld
WG Bobbink
BD Dijker
D ter Doest
FR Leus
JJ Schotsman
LM Heuveling
N Boekema-Bakker
R van Lom
RER Veen
ICT
HC Frens
JC Harkema
MS Vos
RER Veen
J de Jonge
KP Dieleman
R Nelissen
S Bouabdellaoui-Abahai
MTA/Kea
BA Borkent-Raven
H Koffijberg
K Fischer
BA van Hout
IL de Kruif
MP Janssen
Cardiovascular Diseases
A Algra
AG Pijl
AW Hoes
AF Baas
ALM Vlek
B Gramsma
Personnel and Finances 115
BG Brouwer
CSPM Uiterwaal
DJ Piersma
EA Molenaar
FH Rutten
GJ Geersing
JP Greving
KJ Gorter
LEM Perales-Hijman
LT Bakker
M de Weerd
M Edlinger
MF de Beus
MH van der Hoorn-van Kempen
MJA Gondrie
MM Monteban
S Dogan
T Scheltens
US Dasrath
Y van der Graaf
CH Vaartjes
DJ Duits-Kroon
DJW van Noppen-Pinkaarts
FGW Cleveringa
GEHM Rutten
I Sluijs
JWJ Beulens
KJM Janssen
LG Exalto
M Bloemendaal
M Djuanda-Ojemann
M van den Donk
MH Kamphuis
MJ Knol
ML Bots
PCA Jacobs
SS Muthu-Soedamah
TWJ Rikkers
Y Plantinga
YT van der Schouw
Infectious Diseases
AE Schep-Akkerman
APE Sachs
BDL Broekhuizen
CW Helsper
EJ Groen
EM Blijleven
J Bont
JJ Groenendijk
AN van Gorcum
AW van der Velden
C van den Dool
E Hak
EJ Pijpers
GA van Essen
JAR van Bruggen
JMI Vos
116 Annual Report 2007
JP Trapman
L Grigoryan
LMAJ Muller
MEL Bartelink
MJP van Avendonk
MM Kuyvenhoven
PGH Janssen
RHH Groenwold
SJ Damman
KY Tsoi
L Koopman
ME Numans
MJ Warnier
MK van Dijk-Okla
MM Rovers
PM van Eden
SF van Vugt
WG Melsen
Managementteam
AW Hoes
M Kluijtmans
M van der Starre
DE Grobbee
Y van der Graaf
Secretariat
A Koopmans
CE Maekelbergh
EM Blijleven
H Meegdes-Kuiperij
IC Laurens
MA den Hartog
MCE van Eck
N Linnebank-Hillebrand
TLTM Haks-Schoonderwoerd
AI van den Hoeven-van Vriesland
CET de Bruin
GMC Hageman-Raatgever
HA Braun
JC Kusters-Ritman
MC van Straaten
ML van der Linde-Hablous
R de Vries
Management support
A Slimani
GHM Horstink
JC Griffioen
EP Plomp
HGB van Kesteren
JH ter Keurs
Personnel and Finances 117
JJ Molenaar
K Blom-Klein
LJC Kolste
MH Bekkers
WD Baars
Cancer
A Vrieling
AWJ van Winden
EM Monninkhof
JJ Metselaar-van den Bos
M Verheus
PHM Peeters
Unit Health Care Innovations
ABM Simkens
APP Janssen
E Verweij
EML Verschuur
F Hamdaoui El
FL Oosterwijk
GHJ Rosken
H Belkadi
HF van Stel
IFM Schweitzer-Janssen
IL van den Herik
J Thiesen
JJN Urbanus-van Laar
L Catoen
L van Hensbergen
118 Annual Report 2007
JLM Tuithof
K Booden
M Perdon
MME van der Werff
AM May-de Groot
CH van Gils
FJB van Duijnhoven
JJMM Drijvers
PAH van Noord
SG Elias
AJP Schrijvers
BC ten Tusscher
EGJ Ensink
EVH van Velzen
FF Berkhof
GH de Weert-van Oene
GW Westendorp
HA van Oers
I van der Wulp
IJEM Swaans
J Sinke
JCA Trappenburg
KA de Rooij
L Rietveld
LAJ van Egmond
LJ van Veenendaal
MA Smit-Kam
MB Berk
MCA Smit
MF Engel
MS Poeschmann
MYV Homs
O Visser
R Brandenburg
RG van der Meulen
SA de Bruin
VJM Baggen
M Meier
MA van Dijk
MC Kuyvenhoven
ME van Baar
MMJE Makkinga
MS Schrijvers
NM Glerum
PHA Bours
RAJM Bierings
S van Erp
SK Kwee
ZAY Braam
Mental Health
AJG Knoops
CJ Bijkerk
HM Smeets
J Neeleman
MI Geerlings
W Laan
AW Braam
EE Beem
IS van den Hengel-Koot
L Gerritsen
NJ de Wit
Medical Ethics
FG Huisman
JJM van Delden
MC Stuifbergen
GJMW van Thiel
KN Lanting
R van der Graaf-Verhave
Education Epidemiology
A Algra
AMC Raat
B Gramsma
AAHM Weel-van de Heijden
AW Hoes
CH van Gils
Personnel and Finances 119
CLM Appelman
DE Grobbee
E Hak
GMG van der Heijden
HE Hart
I Noorman
JM Houthuysen
KGM Moons
M Bosman
M Perdon
MC de Knegt-Schmidt
MHGH Wildenborg
ML Bots
MM Rovers
P Timmen-Jobse
PHM Peeters
SSL Mol
VR Rambharose
Y van der Graaf
CSPM Uiterwaal
DJ Piersma
EAE Scheele
HAE Vreugdenhil
HM Verkooijen
IE Wesselink-van Meerten
JWJ Beulens
LHM Rikken
M Kluijtmans
M van den Donk
MEL Bartelink
MI Geerlings
MM Kuyvenhoven
MM van Eenige
PAH van Noord
PMA Dudok van Heel
V Coenen
Y Groeneveld
YT van der Schouw
IH Barels
JE Konings
JJS Tjin A Ton
L Truijens
LJ de Boer
M Schouten
M Zwijnenburg
MCGA Albert
MEV Ledoux
MI van der Cingel
MJFM Suijs-Schellekens
MKE Feijen
MM Kuyvenhoven
MS van den Dool-Mulder
PJ Kruithof
S van den Hoeven
S Zwart
SM van Honk
W Mertens
WM van Stempvoort
Education General Practice
A Belgraver
AO Quartero
AR Maille
C Nusse
C Vernooij
CJ Mutsaers
E van Bruggen
EJ van der Jagt
HM Jordan-Carels
AJ van Leeuwen
AP de Graaf
ARJ van Lennep-Sanders
C van Beek
CF Dagnelie
DLM Zwart
EFHM Hendrickx
HHG de Jong
HM Pieters
Education Public Health
MCIH Biesaart
RG van der Meulen
120 Annual Report 2007
J Maaijen
JJ Molenaar
JLM Tuithof
LGM van Berkestijn
M Bogaards-Godschalk
M Terluin
MA Mathot
MED Filippo
MH Bekkers
MI Vermeulen
MJG de Wilt
MLC van Voorst-Vader
MMH van Hemert
NG de Grunt
R Hirsch
S Vossen
SK Kwee
TWPM Wolf-Verschuure
W van der Kraan
O Visser
Leidsche Rijn Health Care Project
DJ Duits-Kroon
K Koppenol
KN Lanting
Personnel and Finances 121
Julius Health Care Centers
AG Pijl
Nursing Science
A Akoudad
AL van Dillen
AM van Straalen
BKG van Meijel
CJ Gamel
EL Meerwijk
G van der Hooft-Leemans
GH Tuijtel
HEM Morselt
JI Dijkstra
JM van Vuuren-Rozendaal
LGC Bouter
M Oosterom
MC Kars
MHF Janssens-Grypdonck
MJ van den Berg
MM van Halm-Walters
WJG Ros
RAE van Damme
AH Horenberg
AM May-de Groot
B van Garden
CAM Goverde
DG Zwiers
F de Boer
GEJ Weustink-Mathu
H Moes
J van Sonsbeek
JJ van der Bijl
JRJ de Leeuw
M Engel
MC de Korte-Verhoef
ME Wigboldus
MJ van Vliet
MM Bosman
RH van Linge
Theoretical Epidemiology & Biostatistics
DB Toll
JAH de Groot
KGM Moons
LM Peelen
R Oudega
Y Vergouwe
AL Zuur
CME van Marissing
DJ van den Berg
EC Carbasius Weber
FM Hollander-Kraaijeveld
J Dopheide
JA Iestra
JM van Maarseveen-Hendriks
JNN van Harten
JWH van der Luyt
K van Halen-Kemp
M Los
N Broekman-Peters
NM de Roos
S Chevalier-Runia
TAM van den Hurk
C Timmer
D Schregardus
E Steenhagen
EH de Jongh-Kampherbeek
GK Hiemstra
J Hiemstra
JCM Schreurs
JMP Leermakers-Vermeer
JW Woestenenk
JWM Renken-Terhaerdt
M de Bruin
M Somer
N Lamarche
PD van Heest-Cooman
SCG van Alst
Adjunct faculty (in Dutch ‘nul-aanstelling’)
Cancer
H Besson
HGM Peters
RCH Vermeulen
Nutritional Sciences & Dietetics
A Gil
AD Michelsen-Huisman
Cardiovascular Diseases
A Mosterd
BG Brouwer
CL Verheugt
EJC van Ameijden
122 Annual Report 2007
HB Bueno de Mesquita
MJ Velthuis
AM Baart
BI Idris
E Peterfai
F Travert
Personnel and Finances 123
H Burger
HJ van Duijn
I Arts
JF Hoekstra
LE Vos
LJM Boonman-de Winter
M Jager-Geurts
M Rietveld-Ernst
MHE Bruins Slot
OP van der Spoel
RGA Ettema
S Sabour
CTSU
AJ van Hoek
CGEM Groot
JJM Stern-van de Heuvel
LD Izeboud
MJF Bastiaansen
PA van Meurs
V Ruda
H Nakhai Pour
HM Smeets
I Oudejans-Mooijaart
K Williamson
LJ Bax
M Edlinger
M Lengyel
MH Zafarmand
N van Geloven
PB van Bemmelen
RP Stolk
SECA de Jong
CA Mulder
E Chalachanova
JL de Bruin
M Dirven
P Novotny
V Puzej
Z Bielicka
Datamanagement
RJT Wit
Education Epidemiology
JE Brussee
General Practice
A Hendrix
124 Annual Report 2007
RP Venekamp
ICT
C van den Broeck
Infectious Diseases
CW Helsper
FAM van Balen
KM van Asselt
LPG Derde
MJ Warnier
W Opstelten
M Lensink
EJM van Gils
I Looijmans
LMAJ Muller
MEE de Roos-Kretzschmar
MW Marcus
Mental Health
HL Keijer
MTA/Kea
BMS Heeg
E Buskens
M Verschuuren
CL van der Poel
GJ Bonsel
MJ Meijboom
Nursing Science
BKG van Meijel
FAJ Fluttert
L Noorland-Schoonhoven
MJ Schuurmans
E van Swieten-Duifjes
JAM Winnubst
MHF Janssens-Grypdonck
S Mujakovic
YS Tjang
AM Mathot
Nutritional Sciences & Dietetics
B Pottinga
CME van Marissing
E de Bruin
E Stravers
Personnel and Finances 125
EJ Sinnige
I Oude Groeniger
J van Riemsdijk
ME Berkenpas
SE Zwolsman
Other
BE de Galan
F Linnebank
G Wolfslag
J Tiebesl
JAG Stooker-Brouwer
JJ Noordzij-van Willigen
MK Van Dijk-Okla
R Dettingmeijer
S Rampal
EK Makkink
I Wijers
K de Jong
RM van Oversteeg
EE Wineke
G Jongebreur
HA Smit
JA Zuidema
JC Kelder
ME Avezaath
MW Kuiper
R Tan-Paap
TJ Huizenga
Financial report
Financial overview 2007
Personnel costs
UMC
€ 8.561.614
UMC
-€ 5.897.567
Projects
€ 5.898.759
External
-€ 4.105.336
GPVT
-€ 3.180.931
Projects
-€ 4.506.732
Investments
Computers
Unit Health Care Innovations
AH Peters
H Kraijo
IFM Schweitzer-Janssen
JH Schaaf
MSA Hady
RW Haneveld
Traveling & Lodging
€ 380.601
Post & Phone
€ 402.548
126 Annual Report 2007
€ 1.813.204
UMC Central
Overhead
G Powell Davies
HJ van der Steeg
IIE van de Woestijne-Staal
JMD Boot
RJP Coenen
€ 114.192
Running costs
Other
Theoretical Epidemiology and Biostatistics
I van der Tweel
Income
€ 952.202
VAT reimbursement
Grand Total
-€ 366.958
-€ 65.598
€ 18.123.121
-€ 18.123.121
Personnel and Finances 127
Organizations and companies providing funding
ADIR
AGIS Zorgverzekeringen nv
Akzo Nobel N.V.
Astmafonds
Astra Zeneca
Bayer HealthCare
Bowling Pfizer
Centrum Maliebaan
College van Zorgverzekeraars
Diabetes Fonds
Districts Huisartsen Vereniging
DGV Nederlands Instituut voor Verantwoord Medicijngebruik
Eli-Lilly bv
European Union
Gemeente Amsterdam
George Institute for International Health
GlaxoSmithKline
Imperial College London
Internationale Stichting Alzheimer Onderzoek
Koningin Wilhelminafonds (Nederlandse Kankerbestrijding)
Lipid Nutrition bv
Landelijk Centrum Verpleging & Verzorging
Landelijke Stichting Beheer Kruiswerk
Merck Sharp en Dohme
Ministerie van Volksgezondheid, Welzijn en Sport
Nederlandse Hartstichting
Nederlandse Organisatie voor Wetenschappelijk onderzoek (ZonMW)
Nederlandse Vaccin Instituut
Novartis Pharma bv
Novo Nordisk Farma bv
Nutricia
Organon nederland bv
Pfizer
Pharmanet
RIVM
Sanofi-Aventis
SBOH
Servier
Schering Plough
Sticares
Stichting centraal fonds Reserves Voormalig Vrijwillige
Ziekenfondsverzekering
Stichting Egris
Stichting Interactie
Stichting Koningsheide
Stichting RIPAG
Stichting Vascular Research Netwerk
Stichting Vecozo
Stichting tot steun VCVGZ
Strangeways Research
The Icelandic Heart Association
The Stanley Medical Research Institute
TNO-voeding
UMC Utrecht
University of Durham
University of Oxford
VU Medical Centre
Wyeth
World Cancer Research Fund
128 Annual Report 2007
Personnel and Finances 129
World Health Organization
Zorgonderzoek Nederland
Zorggroep Almere
130 Annual Report 2007
Personnel and Finances 131
Research Projects (2007)
‘The theme-oriented organisation of our research
contributes to the high quality of the output.’
(Manon Kluijtmans)
Research projects 133
Cardiovascular Diseases
PhD projects, finished 2007
Name
Title
Janssen, K.J.M. Improvements in clinical prediction
(see also Theor. Epi.) research
JC
Discipl
intern
CE
Nakhai Pour,
H.R.
Androgens and selected cardiovascular
risk factors in aging men
intern
CE
Sabour, S.
Calcification of the coronary arteries.
Reproducibility, risk factors and risk
intern
CE
Thoolen, B.J.
Beyond good intentions. The
effectivenes of a proactive selfmanagement intervention in patients
with screen-detected type 2 diabetes
extern
GP,
Psych.
VenmansDiabetes and infections: towards an
Muller, L.M.A.J. optimal treatment strategy in primary
(see also Infectious care
intern
GP
JC
Discipl
diseases)
PhD projects, ongoing
Name
Title
vacature
Cardiovascular effects of severe caloric
restriction: Dutch ‘hongerwinter’ cohort
collaboration
joint
CE
Appelman,
A.P.A. (see also
Early cerebral damage in patients with
manifest vascular disease
joint
CE
Arts, I.
Determinants of disability in older
persons
joint
CE
Avendonk,
M.J.P. van
Insulin therapy in diabetes type 2
patients in general practice
intern
GP
Bauer, F.
IOP Genomics project: The role of
inflammation in obesity-induced type 2
diabetes
intern
CE
Mental Health)
Research Projects 135
extern
CE
Expert patients as a coach in a selfmanagement programme for newly
diagnosed patients with diabetes type 2
joint
GP, NS
Beus, M.F. de
Sudden death in sportsman, SPORTCOR
intern
CE
Bijker, J.
Intra-operative hypotension and
adverse outcome after surgery
extern
CE
Boonman-de
Winter, L.J.M.
Heart failure in diabetes
extern
GP
intern
MTA
Beelen, R.M.J.
Long-term effects of traffic-related air
pollution on respiratory and
cardiovascular mortality.
Berg, M.J. van
den
Borkent-Raven, The relationship between the costB.A.
effectiveness of blood safety measures
and the distribution of patients
receiving blood; the PROTON study
Bozkurt, O.
intern
CE
El Fakiri, F.
Preventive cardiovascular care in
deprived neighbourhoods
extern
GP
Elbers, C.C.
Role of inflammation in obesity-induced
type 2 diabetes, Phd study
joint
CE
Emmelot-Vonk, Effects of testosterone suppl. on
M.H.
functional mobility, quality of life, body
composition, cognitive function, vasc.
ageing, and bone mineral density in
testosterone deficient men, PhD project
1
intern
CE
Engelsen, C.
den
The IJsselstein screening for central
obesity to detect metabolic syndrome
intern
CE, GP
Gast, G.C.M.
A net preventive benefit of
postmenopausal hormone therapy in
peri-menopausal women
joint
CE
Geersing, G.J.
Generalizability of the Wells rule for
excluding pulmonary embolism to
primary care: The AMUSE 2 study
intern
CE, GP
Geerts, C.C.
The relation between early childhood
obesity and arterial disease
intern
CE
Psychological stress and depression as
risk factors for cognitive decline and
Alzheimer’s disease
intern
CE
intern
CE
joint
CE
joint
CE
Evaluation of multidisciplinary care in
cardiovascular disease
intern
CE
Bruggen, J.A.R. IMPETUS: Implementation of shared
van
care guidelines for people with type 2
diabetes
intern
GP
BrugginkAndré de la
porte, P.W.F.
Value of doctor- and nurse directed
multidisciplinary interventions in heart
failure
extern
CE, GP
also Mental Health)
Bruins Slot,
M.H.E.
Improving the early diagnosis of
myocardial infarction in primary care:
the added value of a rapid assay to
detect heart-type FABP, a novel marker
of myocardial injury - PhD project 2.
intern
CE, GP,
MTA
Gondrie, M.J.A. PROVIDI: Prognostic value of
unrequested information in diagnostic
imaging
Cleveringa,
F.G.W.
Diabetes care Inplementation Study
(DIS)
intern
CE, GP
Dogan, S.
Methodological aspects of carotid
intima-media-thickness measurements
in observational and intervention
studies
intern
CE
(see
UDES project pharmacy
Eck, J.W.M. van Complications in first year after
pacemaker implants
also Mental Health)
Brouwer, B.G.
136 Annual Report 2007
Gerritsen, L.
(see
Gorter, P.M.
Insulin resistance and adipose tissue in
the development of vascular diseases in
high-risk patients
Hajer, G.R.
Vascular risk factors and adipocyte
dysfunction in metabolic syndrome
extern
CE
Halkes, P.H.A.
Minor and major vascular diseases of
the brain
extern
CE
Research Projects 137
joint
CE
Pruissen, M.
Genetic determinants for new vascular
events in patients with cerebral
ischaemia
extern
CE
CE, GP
Regieli, J.J.
Prognosis in ischemic heart disease.
Impact and molecular determinants of
collateral circulation - the SMART study
and REGRESS trial cohorts
joint
CE
extern
CE
Rutten, A.
Multi-detector row CT of the heart:
methodological evaluation and
application in high-risk patients
extern
CE
Jongen, L.M.
Cerebral perfusion and cerebral vascular intern
morphology in patients with
symptomatic carotid artery stenosis
CE
Scheltens, T.
Prevention of cardiovascular diseases in
primary care
intern
CE, GP
Sluijs, I.S.
CE
Diagnostic strategies in patients
suspected of heart failure
Knol, M.J.
Psychiatric comorbidity in diabetes
(UDES-project JC)
The effect of environmental as well as
genetic factors on selected biomarkers
of pathophysiological pathways thusfar
known to be involved in the ethiology
of type 2 diabetes
intern
Kelder, J.C.
Spoel, O.P. van
der
Improving the early diagnosis of
myocardial infarction in primary care:
the added value of a rapid assay to
detect heart-type FABP, a novel marker
of myocardial injury - PhD project1.
intern
CE, GP,
MTA
Svircevic, V.
Optimal technique in cardiac anestesia
recovery
extern
CE
Toll, D.B.
Diagnosing deep vein thrombosis in
primary care
intern
CE, GP
Uijl, I.E.M. den
Long term outcome of mild and
moderate haemophilea
intern
CE
Uijl, S.
Optimal diagnostic routing to
determine the indication of surgery in
epilepsy patients
extern
CE
Vaartjes, C.H.
Cerebrovascular disease and peripheral
arterial disease in the Netherlands:
incidence and prognosis
intern
CE
Verheugt, C.L.
Prognosis of adults with congenital
heart disease in the CONCOR national
registry
intern
CE
Jacobs, P.C.A.
The prognostic value of incidental
findings in diagnostic imaging
(PROVIDI)
Janssen, P.G.H.
intern
The Dutch ADDITION Study; As part of
the Anglo-Danish-Dutch study of
intensive treatment in people with
screen detected diabetes in primary care
Jong, S.E.C.A.
de
(DREAM)on: Dutch Randomised
Endovascular Aneurysm Management
Trial - 2nd part.
intern
CE, GP
joint
CE
The etiology of Alzheimer disease: an
innovative hypothesis of depression,
vulnerability an biological interaction
intern
CE
Koffijberg, H.
Modeling complex disease processes:
subarachnoid hemorrhage and frailty
intern
MTA
Laar, F. van de
Nutritional and pharmaceutical
treatment aspects in newly diagnosed
type 2 diabetes patients in general
practice
extern
GP
Determinants of physical aging among
healthy postmenopausal women and
their relation with serum hormone
levels
extern
Determinants of end-of-life decisions in
ALS: prospective study
extern
(see
also Mental Health)
Knoops, A.J.G.
(see also Mental
Health)
Lebrun, C.E.I.
Maessen, M.
Meijs, M.F.L.
Non invasive cardiac imaging
Nijdam, M.E.
OudejansMooijaart, I.
CE
CE
joint
CE
Elevated blood pressure in young adults
intern
CE
Heart failure in the very old
extern
CE
138 Annual Report 2007
(see
also Methodology)
Research Projects 139
Vlak, M.
Triggers for rupture of intracranial
aneurysms
extern
CE
Vlek, A.L.M.
Parameters of cardiovascular diseasethe SMART study (definitive title to be
decided)
intern
CE
Vos, A.M. de
Cardiac imaging in patients with
peripheral arterial disease.
extern
CE
Weerd, M. de
Chronic renal insufficiency in the
Netherlands, incidence and prevalence
+
Is screening of asymptomatic carotid
stenosis to prevent stroke risk cost
effective
intern
CE
Wermer, M.
Aneurysm Screening after surgical
Treatment in Ruptured Aneurysms
(ASTRA)
extern
CE,
MTA
Westerhuis,
M.E.M.H. (see
The cost-effectiveness of ST-analysis of
the fetal electrocardiogram as
compared to fetal blood sampling for
intrapartum monitoring: a randomised
controlled trial
extern
CE
Diagnostic value of an innovative noninvasive diagnostic to determine the
grade of atherosclerosis before
sternotmy in patients scheduled for
cardiac surgery
extern
Genetic risk factors in cardiovascular
disease
intern
also Theor. Epi.)
Zaane, B. van
Zafarmand,
M.H.
CE
Title
Kruif, I.L. de
Prevention of cardiovascular disease
140 Annual Report 2007
Name
Title
Bak, A.A.A.,
Bots, M.L.
Effects of increased convective clearance intern
by online hemodiafiltration on all cause
mortality in chronic hemodialysis
patients
Berg, M.J. van
den
Expectations and preferences of people
with type 2 diabetes mellitus with
regard to changes in primary diabetes
care
intern
CE, GP
Beulens, J.W.J.
Nutrition, Type 2 Diabetes and
Cardiovasular Disease
intern
CE, DT
Bots, M.L.
Optimal risk factor management in CRI
patients and risk of CVD events:
MASTERPLAN
intern
CE
Bots, M.L.
Cardiac imaging and risk of CVD PAD
patients: GROUND study
intern
CE
Bots, M.L.
Carotid intima-media thickness
measurement (CIMT): Is it useful for
clinical practice?
intern
CE
Donk, M. van
den
Quality of life in screen detected type 2
DM patients
intern
CE, GP
Donk, M. van
den
intern
Cognition in screen/detected patients
with type 2 diabetes mellitus in primary
care± two and five years follow/up after
randomisation towards intensive or
standard treatment
CE, GP
CE
Other projects, finished 2007
Name
Other projects, ongoing
JC
Discipl
intern
MTA
JC
Discipl
CE
SMART: Second Manifestations of
Graaf, Y. van
der, Soedamah- ARTerial disease
Muthu, S.S.
intern
CE
Greving, J.P.
intern
CE
Balancing the risks and benefits in
primary prevention. Development of an
individualised approach.
Research Projects 141
Grobbee, D.E.,
SoedamahMuthu, S.S.
Hees, Y. van
intern
ADVANCE: Action in Diabetes and
Vascular Disease, an international
multicenter clinical trial on the effects
of Perindopril-Indapamide and Glicazide
on cardiovascular disease in patients
with diabetes mellitus type 2
Outcomes after aortic valve
replacement. A prognostic cohort study
on survival, quality of life and costs
Kluijtmans, M.
IPD analysis of on- versus off pump
coronary bypass surgery
Onland-Moret, Role of inflammation in obesity-induced
N.C.
type 2 diabetes
Peeters, P.H.M. PROSPECT: European prospective
investigation into cancer and nutrition
(see also Cancer)
 
CE
Infectious Diseases
PhD projects, finished 2007
Klep
intern
CE
joint
CE
intern
CE
Rutten,
G.E.H.M.
NAVIGATOR: Efficacy and safety of long
term administration of nateglinide and
valsartan in the prevention of diabetes
and cardiovascular outcome
intern
GP
Schouw, Y.T.
van der
European Prospective Investigation into
Cardiovascular diseases (EPIC-Heart)
intern
CE
Shahin, G
Outcomes after mitral valve
replacement. A prognostic cohort study
 
Klep
Name
Title
JC
Discipl
Boldin, B.
Mathematical aspects of infectious
disease dynamics
extern
CE
Jansen,
A.G.S.C.
Extending recommendations for
respiratory vaccines: experimental and
non-experimental studies
intern
GP
Leavis, H.L.
Evolutionary insights into CC17
Enterococcus faecium
extern
CE
Top, J.
Molecular epidemiology Enferococcus
faecium from commensal to hospital
adapted pathogen
extern
CE
VenmansDiabetes and infections: towards an
Muller, L.M.A.J. optimal treatment strategy in primary
care
(see also
intern
GP
JC
Discipl
extern
CE
extern
CE
intern
CE
Lower respiratory tract infections in the intern
elderly: Prognostic studies in primary
care
GP
Cardiovascular
Sonsma, A.C.M. Application of nurse practitioners at the intern
vascular center
CE
Peelen, L.M.
diseases)
PhD projects, ongoing
Name
Title
Theoretical epidemiology in
cardiovascular surgery
intern
CE
Aardweg,
Effectiveness of adenoidectomy in
M.T.A. van den children with recurrent upper
respiratory tract infections
Diagnostic prediction rules: innovative
methods to improve their applicability Postdoc project
intern
CE
Ammerlaan,
H.S.M.
Verheus, M.
Does equol-producer capacity
determine beneficial effect of soy?
intern
CE
Bolkenbaas, M. 13-valent pneumococcal conjugate
vaccin efficacy in prevention in
prevention of pneumococcal CAP and
IPD
Wamsteker,
E.W.
HOOP-study: Baseline expectations and
the effect of weight reduction therapy.
Does changing baseline expectations
prevent undesired weight gain within
the first two years after treatment?
intern
DT
Bont, J.
(see
also Theor. Epi.)
Vergouwe, Y.
(see also Theor. Epi.)
142 Annual Report 2007
MRSA, clinical epidemiologie
Research Projects 143
Boonacker,
C.W.B.
Optimizing the transferability and
applicability of trial results to other
countries
intern
CE
Broekhuizen,
B.D.L.
FRESCO study: Diagnostic Strategies for
COPD in coughing patients in general
practice
intern
CE, GP
Derde, L.P.G.
Mastering hOSpital Antibiotic Resistance intern
(MOSAR); ICU trial (WP3)
Dool, C. van
den
Mathematical modeling as an
alternative for clinical trials in
predicting effectiveness of preventive
measures for influenza in healthcare
settings
intern
Local anti-inflammatory treatment in
the prevention of long-term airway
morbidity following hospitalisation for
respiratory syncytial virus infection:
clinical efficacy and immunological
correlates.
extern
Ermers, M.J.J.
CE
Jong, B.M. de
Whistler: Wheezing illness study in
Leidsche Rijn, study deJong
Jongerden, I.P.
Endotracheal suctioning in ICU patients: extern
towards an evidence based guideline
CE, NS
Kempen,
E.E.M.M. van
Transportation noise exposure and
children’s health and cognition
CE
Lemjahdi, H.
Clinical and molecular epidemiology of joint
pseudomonas aeruginos in cystic fibrosis
patients
CE
Looijmans-van
den Akker, I.
Evaluation of influenza vaccinations in
healthy adults
intern
CE, GP
extern
Meijboom, M.J. Cost-effectiveness (CEA/CUA) of
influenza vaccination programmes
during interpandemic & pandemic years
CE, GP
Melsen, W.G.
Nosocomial infections and Mortality
intern
CE
Pijpers, E.J.
CHAMP - Changing behaviour of Health intern
care professionals And the general
public towards a More Prudent use of
anti-microbial agents & Arti-4
GP
Ruskamp, J.M.
extern
Upper respiratory tract infections in
children; the role of atopy,
environmental and life style factors, and
genetic polymorphisms in a prospective
birth cohort study
CE
Scholtens, S.
Breastfeeding in relation to growth,
childhood overweight and asthma in
Dutch children. The PIAMA birth cohort
study.
extern
CE
CE, GP
CE
extern
CE, GP
Gils, E.J.M. van Effect of 2 versus 3 pneumococcal
conjugate vaccinations Prevnar ® on
nasopharyngeal carriage, transmission
and herd immunity; a randomized,
controlled study
joint
Groenwold,
R.H.H.
Control and Quantification of
confounding by indication in nonrandomised studies: Methodological
inquiry using an example of vaccine
effectiveness
intern
Helsper, C.W.
Improving diagnosis in Hepatitis C in
General Practice
intern
GP
Soares da Silva, Air pollution study in São Paulo
A.
extern
CE
Hendrickx,
A.P.A.
Vaccine Development to combat NEF
infections
extern
CE
Steenhof, M.
Risk evaluation of ultrafine (nanosize)
ambient particular matter
extern
CE
Houben, M.L.
Perinatal determinants, including
amniotic fluid inflammation and
innative immunity, of infant wheeze
and RSV lower respiratory infection.
extern
CE
Suarthana, E.
Development of diagnostic models for
occupational asthma in the framework
of a health monitoring system
joint
CE
Vervoort,
S.C.J.M.
Factors influencing therapy-fidelity in
the view of HIV infected patients
extern
NS
144 Annual Report 2007
CE, GP
joint
CE, GP
Research Projects 145
Visscher, S.
Predicting VAP
extern
CE
Vos, J.M.I.
Prestudy optimizing diagnosis of
Community Acquired Pneumonia (CAP)
extern
CE
Vugt, S.F. van
GRACE (WP 09 + 10)
intern
CE, GP
Warnier, M.J.
Optimising COPD care: going for silver
or for gold
intern
GP
Willers, S.M.
Environmental and life style
determinants of childhood asthma and
allergy in birth cohort
extern
CE
Trapman, J.P.
Mathematical modelling of infection
diseases
Velden, A.W.
van der
joint
Implementation of a multiple
intervention aimed at optimising
prescription of antibiotics for respiratory
tract infections, embedded within the
new practice accreditation of the Dutch
College of General Practitioners; a
randomised controlled trial
GP
Verhoeff, M.
The effectiveness of treatment with co- extern
trimoxazol in children with chronic otitis
media
CE
Other projects, finished 2007
Name
Title
JC
Discipl
Niesink, A.
COPD care in general practice;
evaluation of the copd-astma care
protocol
intern
PH
intern
CE
Other projects, ongoing
Name
Title
JC
Discipl
Grigoryan, L.
European project: Mastering hospital
antimicrobial resistance and its spread
into the community
intern
CE
Hak, E.
Utrecht GP Network (HNU)
intern
GP
Hooven, E.C.
van den
Quantification of confounding by
indication
intern
GP
Rovers, M.M.
Which children with acute otitis media
benefit from treatment with antibitics?
An individual patients data metaanalysis
intern
CE, GP
Smeets, H.M.
Optimalising antibiotic prescribing in
respiratory tract infections in general
practice implementation in the Middle
region of the Netherlands.
intern
GP
Strijp, J. van
In-vitro study of anti-inflammatory
activity of Zithromax
intern
GP
146 Annual Report 2007
Research Projects 147
Cancer
Velthuis, M.
extern
PACT-Study: The influence of physical
activity, weight changes and hormone
levels on (breast) cancer risk and cancer
survival
CE
Vernooij, F.
extern
Ovarian cancer treatment in The
Netherlands. The effect of care provider
on the outcomes of treatment between
1996 and 2003
CE,
MTA
PhD projects, finished 2007
Name
Title
JC
Discipl
Verheus, M.
Endocrine determinants of breast
density and breast cancer risk
intern
CE
Winden, A.W.J. The use of proteomics in the etiologic
van
epidemiology of breast cancer
PhD projects, ongoing
Name
Title
JC
Discipl
Braunius, W.
Diagnostic management in patients
with head and neck malignancies
extern
CE
Haars, G.
Influences on mammographic tissues
and patterns
intern
CE
Horrée, N.
Molecular biology in endometrial
carcinogenesis
extern
CE
Kars, M.C.
PRESENCE study: The experiences,
needs, coping strategies and
professional support of parents caring
at home for a child with cancer during
the palliative phase
intern
NS
MR imaging: the efficacy of noninvasive techniques to detect lymph
node involvement in gynecologic
malignancies
joint
Rehabilitation in cancer: Training and
talking? Effects of physical training
versus physical training combined with
cognitive-behavioural therapy
intern
Klerkx, W.
May, A.M.
(see
also Mental Health)
Oosterom, M.
(see also Mental
Health)
Peters, H.G.M.
intern
NUCAI: The effect of comprehensive
counseling by a specialized nurse on
depressive symptoms and quality of life:
a prospective randomised study.
NS
MR in non-palpable breast tumors
CE
148 Annual Report 2007
joint
CE
Other projects, ongoing
Name
Title
JC
Discipl
Duijnhoven,
F.J.B. van
SOR project: fruit and vegetables in
relation to colonrectal cancer in epic.
extern
CE
Elias, S.G.
KWf project Harvard disease risk model
intern
CE
Gamel, C.J.
Care for (relatives of) patients with
cancer
intern
NS
Gils, C.H. van
Carotenoids, vitamin C and risk of
breast cancer in the european
prospective investigation into cancer
and nutrition
joint
CE
Huitema, M.C.
Effectiveness of oncological follow-up
by specialized nurses
joint
NS
Monninkhof,
E.M.
Physical activity and breast cancer risk:
a trial in postmenopausal women
intern
CE
Noord, P.A.H.
van
DOM project: diagnostic investigation
mamma carcinoma
intern
CE
Peeters, P.H.M. PROSPECT: European prospective
investigation into cancer and nutrition
intern
CE
Vrieling, A.
extern
CE
CE
NS
intern
SOR project: fruit and vegetables in
relation to pancreatic cancer in EPIC
Research Projects 149
Psychological stress and depression as
risk factors for cognitive decline and
Alzheimer’s disease
intern
CE
Heeg, B.M.S.
Health economic modeling of complex
systems; the case of schizophrenia
extern
CE
Houtjes, W.
extern
Development of protocol for the
assesment of needs and the application
of individualized nursing interventions
in depressed elderly
NS
Joosten, G.
“Deciding Together”: A research into
the effectiveness of making a
standardised treatment agreement in
the addiction treatment care
extern
PH
Knol, M.J.
Psychiatric comorbidity in diabetes
(UDES-project JC)
joint
CE
Knook, L.M.E.
Prognosis of children referred for
unexplained chronic pain: the PUC
(Pediatric Unexplained Chronic pain)
study
extern
CE
Knoops, A.J.G.
The etiology of Alzheimer disease: an
innovative hypothesis of depression,
vulnerability an biological interaction
intern
CE
Gerritsen, L.
Mental Health
(see
also Cardiovascular
diseases)
PhD projects, finished 2007
Name
Title
JC
Mujakovic, S.
Genetic and psychological determinants intern
of dyspepsia and implications for
treatment
Discipl
CE, GP
PhD projects, ongoing
Name
Title
JC
Discipl
Aanen, M van
Determinants of diagnostic in reflux
disease
extern
GP
Appelman,
A.P.A.
Early cerebral damage in patients with
manifest vascular disease
joint
CE
Bijkerk, C.J.
Irritable bowel syndrome in primary
care
intern
GP
Boonstra, G.
Quiting-study antipsychotic medicine
extern
CE
Bosman, M.
Prevention of self-harm in psychiatric
inpatients
extern
NS
Bozkurt, O.
(see
UDES project pharmacy
diseases)
joint
CE
also Cardiovascular
(see also
Cardiovascular
diseases)
diseases)
Building blocks project: prospective
study on development of
psychopathology within the normal
population
extern
Clignet,
F.G.H.M.
Physical excercise in depressed elderly:
The development of a nursing
intervention
extern
NS
Dieleman, J.M.
Prophylactic corticosteroids in cardiac
surgery
extern
CE
Fluttert, F.A.J.
Prevention of violence in forensic
psychiatry
extern
NS
Breetveld, E.J.
(see
also Cardiovascular
150 Annual Report 2007
CE, GP
Koekkoek, B.
The development and testing of a best- joint
practice programme for nursing care
for chronically depressed patients
NS
Laan, W.
Acetylsalicylic acid as an adjuvant
therapy for schizophrenia
intern
CE
Lee-Kwon, S.
Primary Caregivers perception of a long extern
term care facility for their demented
elders in Korea and intervening factors
of those perceptions
NS
Leeuw, M.G.C.
de
Quality of the working alliance in
Assertive Community Treatment
NS
extern
Research Projects 151
Rehabilitation in cancer: Training and
talking? Effects of physical training
versus physical training combined with
cognitive-behavioural therapy
intern
Determinants of cognitive decay in the
HALE project
extern
CE
Effectiveness of mebeverine in IBS in
Oberndorff
Klein Wolthuis, primary care
A.
extern
CE, GP
Oosterom, M.
NUCAI: The effect of comprehensive
counseling by a specialized nurse on
depressive symptoms and quality of
life: a prospective randomised study.
intern
NS
Multidisciplinary diagnostics of anxiety
related behavioural disorders in
patients with intellectual disabilities
joint
Reincke, C.
A clinical prospective cross-sectional
diagnostic study on the referral for
screening for epilepsy surgery
extern
CE
Smeets, H.M.
ARAMIS: analysis of the effectiveness of extern
a PPI reduction programme
GP
Velden, A.W.
van der
ELISE: placebo determinants of PPI
dependancy.
GP,
MTA
Verkaik, R.
Nursing care for depressed elderly with extern
dementia in nursing homes: A multi
centre intervention study into the
effects of a nursing guideline
May, A.M.
(see
also Cancer)
Meijer, B
(see also Cancer)
Pruijssers, A.C.
intern
NS
Name
Title
JC
Discipl
Meerwijk, E.L.
Development and testing of an
evidence based practice guideline for
nurses to effectively handle suicidality
in patients with schizofrenia or
associated psychotic disorders
intern
NS
Other projects, ongoing
Name
Title
JC
Discipl
Beem, E.E.
Regional case registry of psychiatric
disturbances in the West and Central
Netherlands
intern
CE
Boter, H.
The european first episode
schizophrenia trial
extern
CE
Hage, S.
Self-management strategies for
adolescents with violent behaviour
extern
NS
Matthijs, W.
Treatment of children with functional
disorders or behaviour disorders
extern
MTA
Nuboer, V.S.P.
Prevention of suicide in patients with
schizophrenia
extern
NS
extern
NS
intern
Early diagnosis in child health centers
Stel, H.F. van,
of boisterous behavior in children of 0Swaans,
I.J.E.M., Weert- 4 years
van Oene, G.H.
de
PH
Villevoye, D.P.J. Out of school prevention of alcohol
and drugs in the European countries
extern
PH
intern
Demand driven mental health care in
Utrecht: baseline measurement with
respect to care programming in mental
health facilities in the region Utrecht
PH
NS
NS
Visscher, A.J.M. Prevention of violent behaviour in
patients with Acquired Brain Injury.
extern
NS
Zegwaard, M.I. Family care of elder persons with
chronic psychiatric problems and
difficult behaviour
extern
NS
Zuithoff, N.P.A. Early decision of depression in primary
care: application and theory
intern
152 Annual Report 2007
Other projects, finished 2007
CE, GP
Peijnenburg, R. The development of a nursing
guideline aimed at the reduction of
agitated behaviors in patients with
dementia
Weert-van
Oene, G.H. de
Research Projects 153
Theoretical Epidemiology and Biostatistics
Groenwold,
R.H.H.
Control and Quantification of
confounding by indication in nonrandomised studies: Methodological
inquiry using an example of vaccine
effectiveness
intern
CE, GP
Groot, J.A.H.
de
Diagnostic research in the absence of a
‘gold’ standard.
joint
CE
Heeg, B.M.S.
Health economic modeling of complex
systems; the case of schizophrenia
extern
CE
Idris, B.I.
Long-term outcomes in cardiac surgery
extern
CE
Janssen, M.P.
Transfusion Technology Assessment
collaboration with Sanquin Blood
Supply Foundation
intern
MTA
Kappen, T.
IMplementation of a Prediction rule in extern
Anesthesia practice to improve Costeffectiveness of Treatment of
postoperative nausea and vomiting: the
IMPACT trial
CE
Koopman, L.
Pooling of individual patient data from
clinical trials. Improvement of analyses
of subgroups
intern
CE
Molenaar, E.A.
Research and Development Utrecht
Health Project
intern
CE, GP
PhD projects, finished 2007
Name
Title
Janssen, K.J.M. Improvements in clinical prediction
research
(see also
JC
Discipl
intern
CE
Cardiovascular
diseases)
Roosbroeck,
S.A.H. van
Validation of traffic related air pollution extern
exposure estimates for long-term
studies
CE
PhD projects, ongoing
Name
Title
JC
Discipl
Baart, A.M.
Prediction of future hemoglobin levels
in whole blood and plasma donors
extern
CE,
MTA
Bax, L.J.
Synthesis of clinical research data:
extern
innovations in methods and applications
CE
Boonacker,
C.W.B.
Optimizing the transferability and
applicability of trial results to other
countries
intern
CE
Bruins Slot,
M.H.E.
Improving the early diagnosis of
myocardial infarction in primary care:
the added value of a rapid assay to
detect heart-type FABP, a novel marker
of myocardial injury - PhD project 2.
intern
CE, GP,
MTA
Spoel, O.P. van Improving the early diagnosis of
der
myocardial infarction in primary care:
the added value of a rapid assay to
detect heart-type FABP, a novel marker
of myocardial injury - PhD project 1.
intern
CE, GP,
MTA
Dieleman, J.M. Postoperative cognitive decline
extern
CE
Improving outcomes of cardiac surgery
in elderly patients
extern
CE
Thiel, G.J.M.W. Evidence-based ethics: reflective
van
equilibrium as a method for combining
empirical and ethical elements.
intern
Ettema, R.
Med.
Ethics
Gondrie,
M.J.A.
PROVIDI: Prognostic value of
unrequested information in diagnostic
imaging
intern
CE
Toll, D.B.
intern
CE, GP
Graaf-Verhave, Justice in research ethics
R. van der
154 Annual Report 2007
(see
also Cardiovascular
Diagnosing deep vein thrombosis in
primary care
diseases)
intern
Med.
Ethics
Research Projects 155
Westerhuis,
M.E.M.H. (see
also Cardiovascular
diseases)
The cost-effectiveness of ST-analysis of
the fetal electrocardiogram as
compared to fetal blood sampling for
intrapartum monitoring: a randomised
controlled trial
extern
CE
PhD projects, finished 2007
Other projects, ongoing
Name
Title
JC
Discipl
Hooven, E.C.
van den
Quantification of confounding by
indication
intern
GP
Rovers, M.M.
Methodological challenges of subgroup intern
analyses in IPD meta-analyses
CE
Peelen, L.M.
Theoretical epidemiology in
cardiovascular surgery
intern
CE
intern
Diagnostic prediction rules: innovative
methods to improve their applicability Postdoc project
CE
(see also
Miscellaneous
Name
Title
JC
Discipl
Berg, B. van
den
Physical symptoms that are frequently
unexplained among survivors of the
Enschede fireworks disaster
extern
CE
Coping with itch, a nurse-led
OsMedendorp, H. intervention
van
extern
NS
Vlimmeren,
L.A. van
extern
CE
Cardiovascular
Asymmetry in infancy - The effect of
paediatric physical therapy on the
course of deformational plagiocephaly
and subsequent developmental delay
diseases)
Vergouwe, Y.
(see also
Cardiovascular
diseases)
156 Annual Report 2007
PhD projects, ongoing
Name
Title
JC
Discipl
Berk, M.B.
Evaluation patient organisations
intern
PH
BoelhouwerJacobsen, D.E.
Efficacy of tibolone and raloxine on the extern
maintenance of muscle strength, bone
mineral density and cognitive function
in late postmenopausal women.
CE
Boogaard,
J.M.C.
Integrated assessment of health risks of extern
environmental stressors in Europe
(INTARESE)
CE
Bruijn, C. de
Cognitive behavioural treatment for
sub-acute shoulder disorders
extern
CE
BrunsNeumann, E.E.
Support of parents of premature
children
extern
NS
Buiting, H.
Evaluation of the law on euthanasia
extern
MTA
DijkstraChaves, L.M.
Prevention of pressure ulcers in home
care
extern
NS
Eland-Kok, P.
A patient portal for patients with
constitutional eczema: feasibility and
effectiveness
extern
NS
Research Projects 157
Emmrich, D.
Promotieproject Emmrich,
Verplegingswetenschap
extern
NS
Stuifbergen,
M.
Changing familiy ties and caretaking of
the elderly
intern
MTA
Engel, M.
Palliative care and presence
intern
NS
Sutedja, N.A.
extern
CE
Grul, Y.M.
Attention, care and professionalism in
care for the elderly
extern
NS
Environmental and genetic risk factors
for amyotrophic lateral sclerosis (ALS)
PH
extern
PH
Hoogerduijn, J. Prevention of complications in elderly
after hospital admission
joint
NS
Disease management in patients with
COPD; New stratiegies to improve selfmanagement skills and early detection
of exacerbations
intern
Quality of life in relation to ICU
treatment
Trappenburg,
J.C.A.
Vallenga, D.
extern
NS
Jansen, A.J.M.
Differences in health perception
between physician and patient in
chronically ill children
extern
CE
Risk management in care of mentally
retarded patients with epilepsy
Wassenberg,
M.W.M.
Rapid diagnostics of MRSA
extern
CE
Jong, S.W. de
Population based study on Amyotrophic extern
Lateral Sclerosis Netherlands PAN
CE
Zuurbier,
M.M.M.
extern
CE
Jukema, J.S.
Presence in caring relationships
joint
NS
TRAVEL: Transport Related Air
pollution, Variance in commuting,
Exposure and Lungfunction
Klijn, A.
Efficacy of home-uroflowmetry in
children with dysfunctional voiding
(UFO)
extern
CE
JC
Discipl
Hofhuis, J.
Other projects, ongoing
Name
Title
extern
NS
Belkadi, H.
Beheer kwaliteitsMonitor voor Centrum extern
Maliebaan
PH
Moes, H.
Development and testing of innovation/ intern
implementation measurement
instruments
NS
Bie-de Waal,
M.N.A. de
Stop the care-stops
intern
PH
extern
CE
Reduction of care-delay for multi
trauma patients
PH
Effectiveness of non-invasive artificial
respiration at home in patients with
ALS
Bie-de Waal,
M.N.A. de
intern
Piepers, S.
Buskens, E.
PATMAN: Patient workflow
management systems
intern
MTA
Development and validation of a
multidisciplinary protocol for
withdrawal of artificial breathing on IC
units
joint
Lemmens, L.
Implementation of POS clinics in Dutch
hospitals
extern
CE
Linden, B.A.
van der
Meaning of American integrated care
programmes to Dutch chronically ill
patients
extern
PH
Niesink, A.
Telemonitoring of COPD patients
intern
PH
Rietveld, L.A.
Evaluation of Physician in general
practice
extern
PH
Luiking-Martin, Implementation of evidence based
M-L.
practice
Polet, J.C.
NS
Rademakers, K. Additional value of MRI in prediction of extern
psychomotorical development in
premature children: a cost benefit
analysis
CE
Simkens,
A.B.M.
PH
Evaluation of Physician Assistant
trainees in Dutch general practices.
158 Annual Report 2007
intern
Research Projects 159
Rooij, S.
Early recognition in elderly hospital
patients who are at risk for functional
impairments
extern
NS
Clinical Trial Services Unit / Research Services
Schrijvers,
A.J.P.
Evaluation of periodical indicators of
intern
youth health care in child health centers
PH
Projects 2007 finished
Urbanus-van
Laar, J.J.N.
Evaluation Sylvia Toth Center
intern
Veenendaal,
L.J. van
CIZ
Weert-van
Oene, G.H. de
Project
Title
Activity
PH
Aspirin/
Schizophrenia
Acetylsalicylic acid as an adjuvant
therapy for schizophrenia
M/DM
Other
extern
PH
CIRA
M/DM
CT
IMC benchmarking. Routine Outcome
Monitoring of patients in impatient
motivation centers in substance
dependence care
extern
PH
Study on chronic hepatits-C treatment
with interferon alpha, ribavirin and
amantadine
DEPRESSIE
CT
Weldam,
S.D.W.
Guideline development to stimulate
fluid intake
extern
NS
Pharmacological Treatment of Psychotic M/DM
Depression. Comparance of efficacy at 7
weeks after treatment with venlafaxine,
imipramine, venlafaxine + imipramine.
DIS
Diabeteszorg Implementatie Studie
Comparative study of triage systems in
the Netherlands
intern
PH
Adm./
DM
Other
Wulp, I. van
der
Epi-flu
CT
Implementation of care homes
extern
NS
intern
PH
An observational study to investigate
the incidence of influenza-related
complications in adults between 50-64
years and elderly adults 65 years and
over vaccinated with GSK biologicals
influenza vaccine (Fluarix™)
administered intramuscularly.
Site
Zweers-de
Groot, J.A.M.
EUFEST
The EUropean First Episode
Schizophrenia Trial
M/DM
CT
ILLUMINATE
Site
Phase 3 multi-center, double-blind,
randomized, parallel group evaluation
of the fixed combination torcetrapib/
atorvastatin, administered orally, once
dai ly (QD), compared with atorvastatin
alone, on the occurence of major
cardiovascular events in subjects with
coronary heart disease or risk
equivalents
Other projects, finished
Meier, M.
Organisation of acute care. Demand
and supply of emergency care in the
region of Utrecht
160 Annual Report 2007
CT
Research Projects 161
Site
Randomized, double-blind, placebocontrolled, multinational study
evaluating the safety and
pharmacokinetics of 5 and 10 µg
AVE0010 single doses and the efficacy,
safety and pharmacokinetics of
AVE0010 administered for 6 or 6 weeks,
either once or twice daily, following
dose escalation from 5 to 30 µg in
Japanese and Caucasian type 2 diabetic
patients not adequately controlled with
sulfonylurea and metformin.
CT
Telmisartan
Telmisartan and simvastatin in
hyperlipidemia and hypertension.
Site
CT
UHFO-DD
Utrecht Heart Failure Study –
Diagnostics
M/DM
Other
Zolip
Randomized clinical trial on the efficacy Site
and safety of combination fenofibrate/
simvastatin compared to simvastatin
monotherapy in patients with mixed
dyslipidemia
PDY
Ascertain
Assesment of everolimus in addition to Site
(CIMT
calcineurin inhibitors reduction in
maintenance renal transplant recipients only)
CT
AUDITOR
Atherosclerosis underlying development Site
assessed by intima-media thickness in
patients on Rimonabant
CT
CLA
Possible effects of supplementation
with cis-9, 11 conjugated linoleic acid
on markers of atherosclerosis
Site/DM
CT
CONTRAST
The Dutch Convective Transport Study
M/DM
CT
Diasulin
Falen van metformine en
sulfonylureumderivaat
combinatietherapie: stoppen of
doorgaan met een
sulfonylureumderivaat in combinatie
met insuline glargine bij diabetes type
2 patiënten in de huisartspraktijk.
Site/DM
CT
DREAM
Dutch Randomised Endovascular
Aneurysm Management Trial
M/DM
CT
FAME
Heart-type Fatty Acid binding protein
Site/DM
for early Myocardial infarction Exclusion
Other
FOLLOW-PACE
Complications in first year after
pacemaker implants
DM
Other
CT
Projects, ongoing
Project
Title
ADVANCE
Action in Diabetes and Vascular disease; M
pretax and Diamicron MR Controlled
Evaluation
CT
Grace
Genomics to combat resistance against
antibiotics in community-acquired LRTI
in Europe
PM/DM
Other
Altitude
A randomized, double-blind, placebocontrolled, parallel-group study to
determine whether, in patients with
type 2 diabetes at high risk for
cardiovascular and renal events,
aliskiren, on top of conventional
treatment, reduces cardiovascular and
renal morbidity and mortality.
M
CT
Interact
Validering van de EPIC-vragenlijst over
lichamelijke activiteit (InterAct-studie).
Site
Other
Interaction
Site
A phase 3, randomized, double-blind
trial evaluate the safety, tolerability,
and immunogenicity of a 13-valent
pneumococcal conjugate vaccine when
administered concomitantly with
trivalent inactivated influenza vaccine
in healty adults 65 years of age or older
who are naïve to 23-valent
pneumococcal polysaccharide vaccine
CT”A
162 Annual Report 2007
Research Projects 163
JUPITER
Justification for the use of statins in
primary prevention: an intervention
trial evaluating Rosuvastatin
Site
CT
LRGP
Utrecht Health Monitoring Study
Leidsche Rijn
Site/DM
Other
MASTERPLAN
Multifactorial Approach and Superior
Treatment Efficacy in renal patients
with the aid of nurse practitioners
M/DM
CT
MINOES
Invloed van 2 en 3 Prevenar®
vaccinaties in het RVP pneumokokken
neusdragerschap, transmissie en
‘herdimmunity’: een gerandomiseerd,
gecontroleerd onderzoek.
M/DM
CT
NAVIGATOR
Efficacy and safety of long term
administration of nateglinide and
valsartan in the prevention of diabetes
and cardiovascular outcome.
Site
Perform
Site
Prevention of cerabrovascular and
cardiovascular events if ischaemic origin (IMT’s)
with te rutroban in patients with a
history of ischaemic stroke or transient
ischaemic attack
CAPITA’s Pilots
Community Acquired Pneumonia
Immunization trial in adults-Pilot
studies
Site/DM
Other
SHARP
Study on Heart And Renal Protection
M
CT
The Dutch
ADDITION
Study
As part of the Anglo-Danish-Dutch
study of intensive treatment in people
with screen detected diabetes in
primary care
Site/DM
CT
Zoster
A study to determine the acceptability
of the Zostavax vaccine when
simultaneously offered with the
influenza vaccination in patients of 65
year and above in the general practice
Site/DM
Other
164 Annual Report 2007
067 lipids
A multicenter, randomized, doubleblind, parallel group, 12-week study to
evaluate the efficacy and safety of
extended-release (ER) niacin/
laropiprant. added to statin versus
doubling the dose of statin in patients
with primary hypercholesterolemia of
mixed dyslipidemia.
Site
CT+
CT = Clinical Trial
M = Monitoring & Projectmanagement
PM = Projectmanagement
DM = Datamanagement
CT
CT
Research Projects 165
Vascular Imaging Center (VIC)
Data Management
without participation of Research Services or VIC
Projects 2007 finished
AdRem
A5091003
A5091004
Retinal CT
ADVANCE Retinal Measurements, a
large sub-study of ADVANCE on diabetic
retinopathy and vascular retinal
changes
CIMT
Measurement of carotid intima-media
thickness in a multi centre randomised
controlled trial on lipid lowering (CP529,414/Atorvastatin, Administered
Orally, Once daily (QD) for 24 months,
Compared with Atorvastatin alone) on
progression of carotid intima-media
thickness in patients with Heterozygous
Familial Hypercholesterolaemia:1003 FH
CT
CIMT
CT
Measurement of carotid intima-media
thickness in a multi centre randomised
controlled trial on lipid lowering (CP529,414/Atorvastatin, Administered
Orally, Once daily (QD) for 24 months,
Compared with Atorvastatin alone) on
progression of carotid intima-media
thickness in subjects with Mixed
Hyperlipidemia: 1004MH
Projects, ongoing
AED Projects
Online vragenlijst bij plotselinge dood
other
BLOEDBANK
Datamining gegevens van bloedbanken
other
CHECK
Reuma-onderzoek DIGD
cohort
COCO
Onderzoek naar BLWI bij kinderen
CT
CRINE
Onderzoek naar de prevalentie en incidentie van other
chronische nierinsufficiëntie in Nederland
DECS
Dexamethason gebruik bij hartoperaties
CT
DIASULIN
Trial bij diabetes type 2 patienten in Breda e.o.
CT
DOM
Utrechts cohort t.b.v. opsporing risicofactoren
voor onstaan van borstkanker
cohort
EBCR
Website voor onderwijs Evidence Based Medicine other
EPIC-NL
Combineren van de cohorten PROSPECT (JC) en
MORGEN (RIVM)
cohort
FAME
Evaluatie van hartschade test in huisartsen
praktijk.
CT
FIBRE
Dieet interventies bij Prikkelbare Darm
Syndroom: oplosbaar, onoplosbaar of geen
vezels?
CT
GRACE WP2
IT/datamanagement workpackage binnen
GRACE. (Europees onderzoek naar antibiotica
resistentie)
other
GROUND
CT
Multicenter trial bij patienten met perifeer
vaatlijden, waarbij gekeken wordt of imaging en
vervolgbehandeling gevolgen heeft voor
cardiovasculairrisico binnen 5 jaar.
GGD 18
maanden
Vergelijking tussen consultatiebureaubezoek of
thuisbezoek bij kinderen van 18 maanden bij
GGD Zeeland
other
Hemofilie
Zweden
Vragenlijsten bij hemofilie patiënten in Zweden
other
Projects, ongoing
Organisation
Title
Measurement
Contrast
The Dutch Convective Transport Study IMT measurements
CIMT
CIMT = Carotid intima-media thickness
CT= Clinical Trial
For all studies datamanagement is performed by the Julius Center.
166 Annual Report 2007
CT
Research Projects 167
HNU
cohort
Huisartsen Netwerk Utrecht, database gevuld
met gegevens van 6 huisartsenpraktijken in regio
Utrecht
IMPACT
Onderzoek naar het gebruik van een
predictieregel voor anesthesist op misselijkheid
bij geopereerde patiënten
CT
IMPETUS
Implementatie en evaluatie van transmurale
werkafspraken diabets mellitus
CT
STEM VAN DE Onderzoek naar beleving kwaliteit van zorg bij
PATIENT
diabetespatiënten
Other
KEMA
Verwerking vragenlijsten
other
ST.
QUADRAET
Database gevuld met gegevens alle 20
huisartsenpraktijken in Almere
Cohort
LEUKO
Leukemie-studie bij WKZ
other
ST. RIPAG
NS-2
Nationale Studie 2, database gevuld met
gegevens van 195 huisartsen verspreid over
Nederland
cohort
Datamanagement van een psychiatrisch cohort in Cohort
de regio Utrecht
VAN PELT
Kinderen met reuma
NUCAI
Trial waarbij patienten met kanker in hoofdhalsgebeid op reguliere wijze wordt behandeld
t.o.v. inzet van counseling
CT
ODIN
Ontspanning door Inspanning
other
ONCOREV
Effectiviteit van oncoligische revalidatie op
kwaliteit van leven
CT
OPTICA
Optimising Circulating blood Volume After
Subarachnoid Haemorrhage
OVARIUMCARCINOOM
Database met patiënten met ovariumcarcinoom
cohort
PANTER
PAncreatitis, Necrosectomie versus minimaal
invasieve sTEp up benadeRing
CT
PATIENT­
VEILIGHEID
Onderzoek naar patiëntveiligheid binnen UMC
Utrecht
Other
PEDNET
European paediatric network for Haemophilia
management
Cohort
PGO-O
Pilot preventief gezondheidsonderzoek ouderen
other
PROSPECT
Utrechts cohort t.b.v. leefgewoonten en kanker
en hart-en vaatziekten
Cohort
QUOFUN
Vragenlijsten bij kaakkankerpatiënten
Other
REACTIE
Vergelijking therapietrouw bij verschillende
manieren van risico-omschrijving
Other
168 Annual Report 2007
RODIN
Internationaal Internet based dataverzameling
bij hemofilie patiënten.
Cohort
SPIN UTI
Trial mbt wel/niet preventief geven van
antibiotica bij kinderen met spina bifida
CT
SPIEGEL
Patiëntveiligheid in de huisartsenpraktijk
Other
Other
CT = Clinical Trial
Research Projects 169
Publications 2007
‘A 12 month trial to study the effect of lipid
modifying drugs on carotid intimamedia thickness
progression should precede the launch of a
morbidity and mortality trial.’
(Michiel Bots)
Publications 171
PhD Theses
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
Berg, B. van den (2007, april 05). Physical symptoms that are frequently unexplained among survivors
of the Enschede fireworks disaster. Utrecht University (165 pag.). Prom./coprom.: prof.dr.ir. B.
Brunekreef, L. Grievink, E. Lebret & dr. C.J. Yzermans.
Boldin, B. (2007, september 05). Mathematical aspects of infectious disease dynamics. Utrecht
University (169 pag.). Prom./coprom.: prof. dr. O. Diekmann & prof. dr. M.J.M. Bonten.
Jansen, A.G.S.C. (2007, september 20). Extending recommendations for respiratory vaccines:
experimental and non-experimental studies. Utrecht University. Prom./coprom.: prof.dr. E.A.M.
Sanders, prof. dr. A.W. Hoes & dr. E. Hak.
Janssen, K.J.M. (2007, december 06). Improvements in clinical prediction research. Utrecht University
(159 pag.). Prom./coprom.: prof.dr. K.G.M. Moons, prof.dr. D.E. Grobbee & dr. Y. Vergouwe.
Leavis, H.L. (2007, december 06). Evolutionary insights into CC17 Enterococcus faecium. Utrecht
University (208 pag.). Prom./coprom.: prof.dr. M.J.M. Bonten & dr. R.J.L. Willems.
Mujakovic, S. (2007, december 18). Genetic and psychological determinants of dyspepsia and
implications for treatment. Utrecht University (170 pag.) (Utrecht). Prom./coprom.: prof.dr. D.E.
Grobbee, prof.dr. M. Samsom, dr. N.J. de Wit & dr. M.E. Numans.
Nakhai Pour, H.R. (2007, juli 12). Androgens and selected cardiovascular risk factors in aging men.
Utrecht University (152 pag.). Prom./coprom.: prof.dr. D.E. Grobbee, dr. Y.T. van der Schouw & dr.
H.J.J. Verhaar.
Nieuwenhoven, C. van (2007, april 27). Prevention of ventilator-associated pneumonia: Making a
difference?! Utrecht University. Prom.coprom.: prof.dr. G. Ramsay, prof.dr. C.A. Bruggeman, prof.dr.
M. Bonten & dr. F. van Tiel.
Os-Medendorp, H. van (2007, november 22). Coping with itch, a nurse-led intervention. Utrecht
University. Prom./coprom.: prof.dr. M.H.F. Grypdonck, prof.dr. C.A.F.M. Bruijnzeel-Koomen & dr.
W.J.G. Ros.
Roosbroeck, S.A.H. van (2007, juni 04). Validation of traffic-related air pollution exposure estimates
for long term studies. Utrecht University (139 pag.). Prom./coprom.: prof.dr.ir. B. Brunekreef, G.
Hoek & N.A.H. Janssen.
Sabour, S. (2007, juli 12). Calcification of the coronary arteries. Reproducibility, risk factors and risk.
Utrecht University (121 pag.). Prom./coprom.: prof.dr. D.E. Grobbee & dr. M.L. Bots.
Thoolen, B.J. (2007, oktober 24). Beyond good intentions. The effectiveness of a proactive selfmanagement intervention in patients with screen-detected type 2 diabetes. Utrecht University. Prom./
coprom.: prof. dr. D.T.D. de Ridder, prof. dr. J. Bensing & prof.dr. G.E.H.M. Rutten.
Top, J. (2007, mei 10). Molecular Epidemiology of Enterococcus faecium from commensal to hospital
adapted pathogen. Utrecht University (175 pag.). Prom./coprom.: prof.dr. M.J.M. Bonten & dr. R.J.L.
Willems.
Venmans-Muller, L.M.A.J. (2007, september 11). Diabetes and Infections. Towards an optimal
treatment strategy in primary care. Utrecht University (189 pag.). Prom./coprom.: prof.dr. G.E.H.M.
Rutten, dr. K.J. Gorter & dr. E. Hak.
Verheus, M. (2007, mei 23). Endocrine determinants of breast density and breast cancer risk. Utrecht
University (163 pag.). Prom./coprom.: prof.dr. D.E. Grobbee, dr. C.H. van Gils & dr. P.H.M. Peeters.
Vlimmeren, L.A. van (2007, april 24). Asymmetry in infancy - The effect of paediatric physical
therapy on the course of deformational plagiocephaly and subsequent developmental delay. Utrecht
University. Prom./coprom.: prof.dr. P.J.M. Helders, prof.dr. Y. van der Graaf, dr. R.H.H. Engelbert &
L.N.A. van Adrichem.
Publications 173
International Refereed Publications
Akkerman, A.E., Kuyvenhoven, M.M., Verheij, T.J.M. & Dijk, L. van. Antibiotics in Dutch general
practice: nationwide electronic GP database and national reimbursement rates. Pharmocoepidemiol
Drug Saf. 2007; doi: 10.1002/pds. 1501.
2 Al-Zoughool, M., Dossus, L., Kaaks, R., Clavel-Chapelon, F., Tjonneland, A., Olsen, A., Overvad, K.,
Boutron-Ruault, M.C., Gaulthier, E., Linseisen, J., Chang-Claude, J., Boeing, H., Schulz, M.,
Trichopoulou, A., Chryssa, T., Trichopoulos, D., Berrino, F., Palli, D., Mattiello, A., Tumino, R.,
Sacerdote, C., Bueno de Mesquita, H.B., Boshuizen, H.C., Peeters, P.H.M., Gram, I.T., Braaten, T.,
Lund, E., Chirlaque, M.D., Ardanaz, E., Agudo, A, Larranaga, N., Quiros, J.R., Berglund, G., Manjer, J.,
Lundin, E., Hallmans, G., Khaw, K.T., Bingham, S, Allen, N., Key, T.J., Jenab, M., Cust, A., Rinaldi, S. &
Riboli, E. (2007). Risk of endometrial cancer in relationship to cigarette smoking: Results from the
EPIC study. International Journal of Cancer, 121(12), 2741-2747.
3 Annesi-Maesano, I., Forastiere, F., Kunzli, N. & Brunekreef, B. (2007). Particulate matter, science and
EU policy. European Respiratory Journal, 29(3), 428-431.
4 Arslan, F., Kaya, M.G., Heijden, G.J.M.G. van der & Cengel, A. (2007). Hypertension as a predictor of
adverse cardiac events in patients with borderline fractional flow reserve. Acta Cardiologica, 62(4),
367-372.
5 Baas, A.F., Grobbee, D.E. & Blankensteijn, J.D. (2007). Impact of randomized trials comparing
conventional and endovascular abdominal aortic aneurysm repair on clinical practice. Journal of
Endovascular Therapy, 14(4), 536-540.
6 Bakker, A.M., Mees, S.M., Algra, A. & Rinkel, G.J.E. (2007). Extent of acute hydrocephalus after
aneurysmal subarachnoid hemorrhage as a risk factor for delayed cerebral infarction. Stroke, 38(9),
2496-2499.
7 Bamia, C., Trichopoulos, D., Ferrari, P., Overvad, K., Bjerregaard, L., Tjonneland, A., Halkjaer, J.,
Clavel-Chapelon, F., Kesse, E., Boutron-Ruault, M.C., Boffetta, P., Nagel, G., Linseisen, J., Boeing, H.,
Hoffmann, K., Kasapa, C., Orfanou, A., Travezea, C., Slimani, N., Norat, T., Palli, D., Pala, V., Panico,
S., Tumino, R., Sacerdote, C., Bueno de Mesquita, H.B., Waijers, P.M., Peeters, P.H.M., Schouw, Y.T.
van der, Berenguer, A., Martinez-Garcia, C., Navarro, C., Barricarte, A., Dorronsoro, M., Berglund, G.,
Wirfalt, E., Johansson, I., Johansson, G., Bingham, S, Khaw, K.T., Spencer, E.A., Key, T.J., Riboli, E. &
Trichopoulou, A. (2007). Dietary patterns and survival of older Europeans: The EPIC-Elderly Study
(European Prospective Investigation into Cancer and Nutrition). Public Health Nutrition, 10(6), 590598.
8 Bax, L.J., Yu, L.M., Ikeda, N. & Moons, K.G.M. (2007). A systematic comparison of software dedicated
to meta-analysis of causal studies. BMC Medical Research Methodology [E], 7, 40.
9 Beelen, R.M.J., Hoek, G., Fischer, P., Brandt, P.A. v.d. & Brunekreef, B. (2007). Estimated longterm
outdoor air pollution concentrations in a cohort study. Atmospheric Environment, 41(7), 1343-1358.
10 Bendermacher, B.L.W., Teijink, J.A., Willigendael, E.M. van, Bartelink, M.E.L., Peters, R.J., Bie, R.A.
de, Büller, H.R., Boiten, J., Langenberg, M & Prins, M.H. (2007). A clinical prediction model for the
presence of peripheral arterial disease - the benefit of screening individuals before initiation of
measurement of the ankle-brachial index: an observational study. Vascular Medicine, 12(1), 5-11.
11 Benders, M.J.N.L., Groenendaal, F., Uiterwaal, C.S.P.M., Nikkels, P.G.J., Bruinse, H.W., Nievelstein,
R.A.J. & Vries, L.S. de (2007). Maternal and Infant Characteristics Associated With Perinatal Arterial
Stroke in the Preterm Infant. Stroke, 38(6), 1759-1765.
12 Berg, H.M. van den, Groot, Ph.G. de & Fischer, K. (2007). Phenotypic heterogeneity in severe
hemophilia. Journal of Thrombosis and Haemostasis, 5(suppl 1), 151-156.
1
174 Annual Report 2007
13 Bernal, M., Haro, J.M., Bernert, S., Brugha, T., Graaf, R.M. de, Bruffaerts, R., Lepine, J.P., Girolamo, G.,
Vilagut, G., Gasquet, I., Torres, J.V., Kovess, V., Heider, D., Neeleman, J., Kessler, R. & Alonso, J. (2007).
Risk factors for suicidality in Europe: results from the ESEMED study. Journal of Affective Disorders,
101(1-3), 27-34.
14 Besselink, M.G.H., Verwer, T.J., Schoenmaeckers, E.J., Buskens, E., Ridwan, B.U., Visser, M.R.,
Nieuwenhuijs, V.B. & Gooszen, H.G. (2007). Timing of surgical intervention in necrotizing
pancreatitis. Archives of Surgery, 142(12), 1194-1201.
15 Beulens, J.W.J., Bruijne, L.M. de, Stolk, R.P., Peeters, P.H.M., Bots, M.L., Grobbee, D.E. & Schouw,
Y.T. van der (2007). High dietary glycemic load and glycemic index increase risk of cardiovascular
disease among middle-aged women: a population-based follow-up study. Journal of the American
College of Cardiology, 50(1), 14-21.
16 Beus, M.F. de & Mosterd, A. (2007). The SPORTCOR registry: a national databank for sports
cardiology. Netherlands Heart Journal, 15(6), 207-208.
17 Beus, M.F. de, Mosterd, A. & Grobbee, D.E. (2007). Sudden cardiac death in athletes: An overview.
Current Cardiovascular Risk Reports, 1, 349-351.
18 Bijker, J.B., Klei, W.A. van, Kappen, T.H., Wolfswinkel, L. van, Moons, K.G.M. & Kalkman, C.J. (2007).
Incidence of intraoperative hypotension as a function of the chosen definition: literature definitions
applied to a retrospective cohort using automated data collection. Anesthesiology, 107, 213-220.
19 Bleeker, S.E., Derksen-Lubsen, G., Grobbee, D.E., Donders, A.R.T., Moons, K.G.M. & Moll, H. (2007).
Validating and updating a prediction rule for serious bacterial infection in patiens with fever without
source. Acta Paediatrica, 96, 100-104.
20 Bobbink, W.G., Gorter, K.J., Rutten, G.E.H.M., Wens, J., Claramunt, X.C., Topsever, P. & Khunti, K.
(2007). The EUCCLID study: Proposed European study on care and complications in people with
type 2 diabetes in primary care. Primary Care Diabetes, 1(3), 167-172.
21 Boelens, J.J., Wynn, R.F., O’meara, A., Veys, P., Bertrand, Y., Souillet, G., Wraith, J.E., Fischer, A,
Cavazanna-Calvo, M., Sykora, K., Sedlacek, P., Rovelli, A., Uiterwaal, C.S.P.M. & Wulffraat, N.M.
(2007). Outcomes of hematopoietic stem cell transplantation for Hurler’s syndrome in Europe: a risk
factor analysis for graft failure. Bone Marrow Transplantation, 40(3), 225-233.
22 Boldin, B., Bonten, M.J.M. & Diekmann, O. (2007). Relative effects of barrier precautions and topical
antibiotics on nosocomial bacterial transmission: results of multi-compartment models. Bulletin of
Mathematical Biology, 69(7), 2227-2248.
23 Bollen, C.W., Uiterwaal, C.S.P.M. & Vught, A.J. van (2007). Meta-regression analysis of highfrequency ventilation vs conventional ventilation in infant respiratory distress syndrome. Intensive
Care Medicine, 33(4), 680-688.
24 Bom, J.G. van der, Gouw, S.C. & Berg, H.M. van den (2007). Response: Immunogenicity of factor
VIII concentrates in patients with hemophilia: a randomized clinical trial is warranted. Blood, 110(8),
3084-3084.
25 Bom, J.G. van der, Gouw, S.C. & Berg, H.M. van den (2007). Response: Plasma-derived or
recombinant factor VIII products and inhibitors in previously untreated patients with severe
hemophilia. Blood, 110(3), 1074-1075.
26 Bont, J., Hak, E., Birkhoff, C.E., Hoes, A.W. & Verheij, Th.J.M. (2007). Is co-morbidity taken into
account in the antibiotic management of elderly patients with acute bronchitis and COPD
exacerbations? Family Practice, 24(4), 317-322.
27 Bont, J., Hak, E., Hoes, A.W., Schipper, M, Schellevis, F.G. & Verheij, Th.J.M. (2007). A prediction
rule for elderly primary-care patients with lower respiratory tract infections. European Respiratory
Journal, 29(5), 969-975.
28 Bootsma, M.C., Bonten, M.J.M., Nijssen, S., Fluit, A.C. & Diekmann, O. (2007). An algorithm to
estimate the importance of bacterial acquisition routes in hospital settings. American Journal of
Epidemiology, 166(7), 841-851.
Publications 175
29 Borggreve, S.E., Hillege, H.L., Dallinga-Thie, G., Jong, P.E. de, Wolffenbuttel, B.H., Grobbee, D.E. &
Dullaart, R.P.F. (2007). High plasma cholesteryl ester transfer protein levels may favour reduced
incidence of cardiovascular events in men with low triglycerides. European Heart Journal, 28(8),
1012-1018.
30 Bots, M.L., Baldasarre, D., Simon, A., Groot, E. de, O’Leary, D.H., Riley, W., Kastelein, J.J. & Grobbee,
D.E. (2007). Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations?
European Heart Journal, 28(4), 398-406.
31 Bots, M.L., Remme, W.J., Luscher, T.F., Fox, K.M., Bertrand, M., Ferrari, R., Simoons, M.L. &
Grobbee, D.E. (2007). ACE inhibition and endothelial function: main findings of PERFECT, a substudy of the EUROPA trial. Cardiovascular Drugs and Therapy, 21(4), 269-279.
32 Bots, M.L., Visseren, F.L.J., Evans, G.W., Riley, W.A., Revkin, J.H., Tegeler, C.H., Shear, C.L., Duggan,
W.T., Vicari, R.M., Grobbee, D.E. & Kastelein, J.J. (2007). Torcetrapib and carotid intima-media
thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial. Lancet,
370(9582), 153-160.
33 Bozkurt, O., Boer, A. de, Grobbee, D.E., Heerdink, E.R., Burger, H. & Klungel, O.H. (2007).
Pharmacogenetics of glucose-lowering drug treatment: a systematic review. Molecular Diagnosis &
Therapy, 11(8), 291-302.
34 Brands, A.M.A., Biessels, G.J., Kappelle, L.J., Haan, E.H.F. de, Valk, H.W. de, Algra, A. & Kessels, R.P.C.
(2007). Cognitive Functioning and Brain MRI in Patients with Type 1 and Type 2 Diabetes Mellitus: A
Comparative Study. Dementia and Geriatric Cognitive Disorders, 23(5), 343-350.
35 Brauer, M., Hoek, G., Jongste, J.C. de, Gerritsen, J., Postma, D.S., Kerkhof, M. & Brunekreef, B.
(2007). Air pollution and development of asthma, allergy and infections in a birth cohort. European
Respiratory Journal, 29(5), 879-888.
36 Braun, K.P.J., Rafay, M.F., Uiterwaal, C.S.P.M., Pontigon, A.M. & Deveber, G. (2007). Mode of onset
predicts etiological diagnosis of arterial ischemic stroke in children. Stroke, 38(2), 298-302.
37 Bree, L. van, Fudge, N., Tuomisto, J.T. & Brunekreef, B. (2007). Closing the gap between science and
policy on air pollution and health. Journal of Toxicology and Environmental Health A, 70(3-4), 377381.
38 Breekveldt-Postma, N.S., Koerselman, J., Erkens, J.A., Lammers, J.W.J. & Herings, R.M.C. (2007).
Enhanced persistence with tiotropium compared with other respiratory drugs in COPD. Respiratory
Medicine, 101(7), 1398-1405.
39 Brouha, X.D.R., Tromp, D.M., Koole, R., Hordijk, G.J., Winnubst, J.A.M. & Leeuw, J.R.J. de (2007).
Professional delay in head and neck cancer patiënts: Analysis of the diagnostic pathway. Oral
Oncology, 43(6), 551-556.
40 Brouwer, B.G., Visseren, F.L.J. & Graaf, Y. van der (2007). The effect of leisure-time physical activity
on the presence of metabolic syndrome in patients with manifest arterial disease. The SMART study.
American Heart Journal, 154(6), 1146-1152.
41 Brouwer, B.G., Visseren, F.L.J., Stolk, R.P. & Graaf, Y. van der (2007). Abdominal Fat and Risk of
Coronary Heart Disease in Patients with Peripheral Arterial Disease. Obesity (Silver Spring), 15(6),
1623-1630.
42 Brouwer, C.N.M., Schilder, A.G.M., Stel, H.F. van, Rovers, M.M., Veenhoven, R.H., Grobbee, D.E.,
Sanders, E.A.M. & Maille, A.R. (2007). Reliability and validity of functional health status and healthrelated quality of life questionnaires in children with recurrent acute otitis media. Quality of Life
Research, 16(8), 1357-1373.
43 Bruggen, J.A.R. van, Gorter, K.J., Stolk, R.P. & Rutten, G.E.H.M. (2007). Shared and delegated
systems are not quick remedies for improving diabetes care: A systematic review. Primary Care
Diabetes, 1(2), 59-68.
44 Bruggink-André de la Porte, P.W.F., Lok, DJ, Veldhuisen, D.J. van, Wijngaarden, J. van, Cornel, J.H.,
Zuithoff, N.P.A., Badings, E. & Hoes, A.W. (2007). Added value of a physician-and-nurse-directed
heart failure clinic: results from the Deventer-Alkmaar heart failure study. Heart, 93(7), 819-825.
45 Bruijn, C. de, Bie, R.A. de, Geraets, J., Goossens, M., Heuvel, W.J. van den, Heijden, G.J.M.G. van der,
Candel, M. & Dinant, G.J. (2007). Effect of an education and activation programme on functional
limitations and patient-perceived recovery in acute and sub-acute shoulder complaints - a
randomised clincal trial. BMC Musculoskeletal Disorders [E], 8(1), 112-112.
46 Bruin, M.L. de, Langendijk, P.N.J., Koopmans, R.P., Wilde, A., Leufkens, H.G.M. & Hoes, A.W. (2007).
In-hospital cardiac arrest is associated with use of non-antiarrhythmic QTc-prolonging drugs. British
Journal of Clinical Pharmacology, 63(2), 216-223.
47 Brunekreef, B. (2007). Health effects of air pollution observed in cohort studies in Europe. Journal of
Exposure Science and Environmental Epidemiology, 17(S2), S61-S65.
48 Brunekreef, B., Miller, B.G. & Hurley, J.F. (2007). The brave new world of lives sacrificed and saved,
deaths attributed and avoided. Epidemiology, 18(6), 785-788.
49 Bruns, A.H.W., Oosterheert, J.J., Prokop, M., Lammers, J.W.J., Hak, E. & Hoepelman, A.I.M. (2007).
Patterns of Resolution of Chest Radiograph Abnormalities in Adults Hospitalized with Severe
Community-Acquired Pneumonia. Clinical Infectious Diseases, 45(8), 983-991.
50 Buiting, H.M., Delden, J.J.M. van, Rietjens, J.A.C., Onwuteaka-Philipsen, B.D., Bilsen, J., Fischer, S.,
Lofmark, R., Miccinesi, G., Norup, M. & Heide, A. van der (2007). Forgoing artifical nutrition or
hydration in patients nearing death in six European countries. The journal of pain and symptom
management, 34(3), 305-314.
51 Burger, H. & Neeleman, J. (2007). A glossary on psychiatric epidemiology. Journal of Epidemiology
and Community Health, 61(3), 185-189.
52 Buskens, E., Staaij, B.K. van, Akker, J. van den, Hoes, A.W. & Schilder, A.G.M. (2007).
Adenotonsillectomy or watchful waiting in patients with mild to moderate symptoms of throat
infections or adenotonsillar hypertrophy: a randomized comparison of costs and effects. Archives of
Otolaryngology - Head & Neck Surgery, 133(11), 1083-1088.
53 Caudri, D., Wijga, A., Gehring, U., Brunekreef, B., Kerkhof, M., Hoekstra, M., Gerritsen, J. & Jongste,
J.C. de (2007). Respiratory symptoms in the first 7 years of life and birth weight at term: the PIAMA
birth cohort. American Journal of Respiratory and Critical Care Medicine, 175(10), 1078-1085.
54 Clarke, J., Tulder, M.W. van, Blomberg, S., Vet, H.C.W. de, Heijden, G.J.M.G. van der, Bronfort, G. &
Bouter, L.M. (2007). Traction for low-back pain with or without sciatica. The Cochrane Database of
Systematic Reviews [E], apr 18(2), CD003010.
55 Cleveringa, F.G.W., Gorter, K.J., Donk, M. van den, Pijman, P.L.W. & Rutten, G.E.H.M. (2007). Task
delegation and computerized decision support reduce coronary heart disease risk factors in type 2
diabetes patients in primary care. Diabetes Technology & Therapeutics, 9(5), 473-481.
56 Coenen, S., Ferech, M., Haaijer-Ruskamp, F.M., Butler, C.C., Stichele, R. Vander, Verheij, Th.J.M.,
Monnet, D.L., Little, P. & Goossens, H.H.L.M. (2007). European Surveillance of Antimicrobial
Consumption (ESAC): quality indicators for outpatient antibiotic use in Europe. Quality & Safety in
Health Care, 16(6), 440-445.
57 Crouse, J.R., Grobbee, D.E., O’Leary, D.H., Bots, M.L., Evans, G.W., Palmer, M.K., Riley, W.A. &
Raichlen, J.S. (2007). Carotid intima-media thickness in low-risk individuals with asymptomatic
atherosclerosis: baseline data from the METEOR study. Current Medical Research and Opinion,
23(3), 641-648.
58 Crouse, J.R., Raichlen, J.S., Riley, W.A., Evans, G.W., Palmer, M.K., O’Leary, D.H., Grobbee, D.E. &
Bots, M.L. (2007). Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk
individuals with subclinical atherosclerosis: the METEOR trial. JAMA-Journal of The American
Medical Association, 297(12), 1344-1353.
176 Annual Report 2007
Publications 177
59 Cust, A., Allen, N.E., Rinaldi, S., Dossus, L., Friedenreich, C.M., Olsen, A., Tjonneland, A., Overvad,
K., Clavel-Chapelon, F., Boutron-Ruault, M.C., Linseisen, J., Chang-Claude, J., Boeing, H., Schulz, M.,
Benetou, V., Trichopoulou, A., Trichopoulos, D., Palli, D., Berrino, F., Tumino, R., Mattiello, A., Vineis,
P., Quiros, J.R., Agudo, A, Sanchez, M.J., Larranaga, N., Navarro, C., Ardanaz, E., Bueno de Mesquita,
H.B., Peeters, P.H.M., Gils, C.H. van, Bingham, S, Khaw, K.T., Key, T.J., Slimani, N., Riboli, E. &
Kaaks, R. (2007). Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk;
Results from the European prospective investigation into cancer and nutrition. International Journal
of Cancer, 120(12), 2656-2664.
60 Cust, A., Kaaks, R., Friedenreich, C.M., Bonnet, F., Laville, M., Tjonneland, A., Olsen, A., Overvad, K.,
Jakobsen, M.U., Chajes, V., Clavel-Chapelon, F., Boutron-Ruault, M.C., Linseisen, J., Lukanova, A.,
Boeing, H., Pischon, T., Trichopoulou, A., Christina, B., Trichopoulos, D., Palli, D., Berrino, F., Panico,
S., Tumino, R., Sacerdote, C., Gram, I.T., Lund, E., Quiros, J.R., Travier, N., Martinez-Garcia, C.,
Larranaga, N., Chirlaque, M.D., Ardanaz, E., Berglund, G., Lundin, E., Bueno de Mesquita, H.B.,
Duijnhoven, F.J.B van, Peeters, P.H.M., Bingham, S., Khaw, K.T., Allen, N., Key, T.J., Ferrari, P.,
Rinaldi, S., Slimani, N. & Riboli, E. (2007). Metabolic syndrome, plasma lipid, lipoprotein and glucose
levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and
Nutrition (EPIC). Endocrine-related Cancer, 14(3), 755-767.
61 Cust, A., Kaaks, R., Friedenreich, C.M., Bonnet, F., Laville, M., Lukanova, A., Rinaldi, S., Dossus, L.,
Slimani, N., Lundin, E., Tjonneland, A., Olsen, A., Overvad, K., Clavel Chapelon, F., Mesrine, S.,
Joulin, V., Linseisen, J., Rohrmann, S., Pischon, T., Boeing, H.H., Trichopoulos, D., Trichopoulou, A.,
Benetou, V., Palli, D., Berrino, F., Tumino, R., Sacerdote, C., Mattiello, A., Quiros, J.R., Mendez, M.,
Sanchez, M.J., Larranaga, N., Tormo, M.J., Ardanaz, E., Bueno de Mesquita, H.B., Peeters, P.H.M.,
Gils, C.H. van, Khaw, K.T., Bingham, S, Allen, N., Key, T.J., Jenab, M. & Riboli, E. (2007). Plasma
adiponectin levels and endometrial cancer risk in pre- and post-menopausal women. Journal of
Clinical Endocrinology and Metabolism, 92(1), 255-263.
62 Cust, A., Slimani, N., Kaaks, R., Bakel, M. van, Biessy, C., Ferrari, P., Laville, M., Tjonneland, A., Olsen,
A., Overvad, K., Lajous, M., Clavel-Chapelon, F., Boutron-Ruault, M.C., Linseisen, J., Rohrmann, S.,
Nothlings, U., Boeing, H., Palli, D., Sieri, S., Panico, S., Tumino, R., Sacerdote, C., Skeie, G., Engeset,
D., Gram, I.T., Quiros, J.R., Jakszyn, P., Sanchez, M.J., Larranaga, N., Navarro, C., Ardanaz, E., Wirfalt,
E., Berglund, G., Lundin, E., Hallmans, G., Bueno de Mesquita, H.B., Du, H., Peeters, P.H.M.,
Bingham, S, Khaw, K.T., Allen, N.E., Key, T.J., Jenab, M. & Riboli, E. (2007). Dietary Carbohydrates,
Glycemic Index, Glycemic Load, and Endometrial Cancer Risk within the European Prospective
Investigation into Cancer and Nutrition Cohort. American Journal of Epidemiology, 166(8), 912-923.
63 Danesh, J., Saracci, R., Berglund, G., Feskens, E.J.M., Overvad, K., Panico, S., Thompson, S.J., Fournier,
A., Clavel-Chapelon, F., Canonico, M., Kaaks, R., Linseisen, J., Boeing, H., Pischon, T., Weikert, C.,
Olsen, A., Tjonneland, A., Johnsen, S.P., Jensen, M.K., Quiros, J.R., Svatetz, C.A., Perez, M.J.,
Larranaga, N., Sanchez, C.N., Iribas, C.M., Bingham, S, Khaw, K.T., Wareham, N., Key, T.J., Roddam,
A., Trichopoulou, A., Benetou, V., Trichopoulos, D., Masala, G., Sieri, S., Tumino, R., Sacerdote, C.,
Mattiello, A., Verschuren, W.M., Bueno de Mesquita, H.B., Grobbee, D.E., Schouw, Y.T. van der,
Melander, O., Hallmans, G., Wennberg, P.W., Lund, E., Kumle, M., Skeie, G., Ferrari, P., Slimani, N.,
Norat, T. & Riboli, E. (2007). EPIC-Heart: the cardiovascular component of a prospective study of
nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European
countries. European Journal of Epidemiology, 22(2), 129-141.
64 Delden, J.J.M. van (2007). Terminal sedation: source of a restless ethical debate. Journal of Medical
Ethics, 33(4), 187-188.
65 Diamond, G.A., Bax, L.J., Kaul, S. (2007) Uncertain effects of rosiglitazone on the risk for myocardial
infarction and cardiovascular death. Annals of Internal Medicine, 147, 578-581.
66 Dietrich, A., Riese, H., Sondeijker, F, Greaves-Lord, K., Roon, A.M., Ormel, J., Neeleman, J. &
Rosmalen, J.G. (2007). Externalizing and internalizing problems in relation to autonomic function: a
population-based study in preadolescents. Journal of the American Academy of Child and Adolescent
Psychiatry, 46(3), 378-386.
67 Dijk, D. van, Spoor, M., Hijman, R., Nathoe, H.M., Borst, C., Jansen, E.W., Grobbee, D.E., Jaegere,
P.P.T. de & Kalkman, C.J. (2007). Cognitive and cardiac outcomes 5 years after off-pump vs on-pump
coronary artery bypass graft surgery. JAMA-Journal of The American Medical Association, 297(7),
701-708.
68 Dijk, K. van, Bom, J.G. van der, Fischer, K., Groot, Ph.G. de & Berg, H.M. van den (2007). Phenotype
of severe hemophilia A and plasma levels of risk factors for thrombosis. Journal of Thrombosis and
Haemostasis, 5, 1062-1064.
69 Dorhout Mees, S.M., Bergh, W.M. van den, Algra, A. & Rinkel, G.J.E. (2007). Achieved serum
magnesium concentrations and occurrence of delayed cerebral ischaemia and poor outcome in
aneurysmal subarachnoid haemorrhage. Journal of Neurology, Neurosurgery and Psychiatry, 78(7),
729-731.
70 Dorhout Mees, S.M., Bergh, W.M. van den, Algra, A. & Rinkel, G.J.E. (2007). Antiplatelet therapy for
aneurysmal subarachnoid haemorrhage. The Cochrane Database of Systematic Reviews [E], oct
17(4), CD006184.
71 Dorhout Mees, S.M., Rinkel, G.J.E., Feigin, V.L., Algra, A., Bergh, W.M. van den, Vermeulen, M. &
Gijn, J. van (2007). Calcium antagonists for aneurysmal subarachnoid haemorrhage. The Cochrane
Database of Systematic Reviews [E], Jul 18(3), CD000277.
72 Duijn, H.J. van, Kuyvenhoven, M.M., Schellevis, F.G. & Verheij, Th.J.M. (2007). Illness behaviour
and antibiotic prescription in patients with respiratory tract symptoms. British Journal of General
Practice, 57(540), 561-568.
73 Duijn, H.J. van, Kuyvenhoven, M.M., Tiebosch, H.M., Schellevis, F.G. & Verheij, Th.J.M. (2007).
Diagnostic labelling as determinant of antibiotic prescribing for acute respiratory tract episodes in
general practice. BMC Family Practice, 20(8), 55-55.
74 Duijnhoven, F.J.B van, Peeters, P.H.M., Warren, R.M., Bingham, S, Noord, P.A.H. van, Monninkhof,
E.M., Grobbee, D.E. & Gils, C.H. van (2007). Postmenopausal hormone therapy and changes in
mammographic density. Journal of Clinical Oncology, 25(11), 1323-1328.
75 Eck, J.W.M. van, Hemel, N.M. van, Zuithof, P., Asseldonk, J.P. van, Voskuil, T.L., Grobbee, D.E. &
Moons, K.G.M. (2007). Incidence and predictors of in-hospital events after first implantation of
pacemakers. Europace, 9(10), 884-889.
76 Effing, T, Monninkhof, E.M., Valk, P. van der, Palen, J. van der, Herwaarden, C. van, Partidge, M.,
Walters, E. & Zielhuis, G.A. (2007). Self-management education for patients with chronic obstructive
pulmonary disease. The Cochrane Database of Systematic Reviews [E], oct 17(4), CD002990.
77 Ege, M., Frei, R., Bieli, C., Schram-Bijkerk, D., Waser, M., Benz, M.R., Weiss, G., Nyberg, F., Hage, M.
van, Pershagen, G., Brunekreef, B., Riedler, J., Lauener, R., Braun-Fahrlander, C. & Mutius, E. von
(2007). Not all farming environments protect against the development of asthma and wheeze in
children. Journal of Allergy and Clinical Immunology, 119(5), 1140-1147.
78 Ekkelenkamp, M.B., Verhoef, J. & Bonten, M.J.M. (2007). Quantifying the relationship between
Staphylococcus aureus bacteremia and S. aureus bacteriuria: a retrospective analysis in a tertiary care
hospital. Clinical Infectious Diseases, 44(11), 1457-1459.
79 El Fakiri, F., Bruijnzeels, M.A. & Hoes, A.W. (2007). No evidence for marked ethnic differences in
accuracy of self-reported diabetes, hypertension, and hypercholesterolemia. Journal of Clinical
Epidemiology, 60(12), 1271-1279.
80 Elbers, C.C., Onland-Moret, N.C., Franke, L.H., Niehoff, A.G., Schouw, Y.T. van der & Wijmenga, C.
(2007). A strategy to search for common obesity and type 2 diabetes genes. Trends in Endocrinology
and Metabolism, 18(1), 19-26.
178 Annual Report 2007
Publications 179
81 Elias, S.G., Noord, P.A.H. van, Peeters, P.H.M., Tonkelaar, I. den, Kaaks, R. & Grobbee, D.E. (2007).
Menstruation during and after caloric restriction: The 1944-1945 Dutch famine. Fertility and Sterility,
88(4 Suppl), 1101-1107.
82 Elias, S.G., Peeters, P.H.M., Grobbee, D.E. & Noord, P.A.H. van (2007). Transient caloric restriction
and cancer risk (The Netherlands). Cancer Causes & Control, 18(1), 1-5.
83 ESPRIT Study Group, The, Algra, A. & Kappelle, L.J. (2007). Medium intensity oral anticoagulants
versus aspirin after cerebral ischaemia of arterial origin (ESPRI): a randomised controlled trial.
Lancet Neurology, 6(2), 115-124.
84 Ferrari, P., Jenab, M., Norat, T., Moskal, A., Slimani, N., Olsen, A., Tjonneland, A., Overvad, K., Jensen,
M.K., Boutron-Ruault, M.C., Clavel-Chapelon, F., Morois, S., Rohrmann, S., Linseisen, J., Boeing, H.,
Bergmann, M., Kontopoulou, D., Trichopoulou, A., Kassapa, C., Masala, G., Krogh, V., Vineis, P.,
Panico, S., Tumino, R., Gils, C.H. van, Peeters, P.H.M., Bueno de Mesquita, H.B., Ocké, M.C., Skeie,
G., Lund, E., Agudo, A., Ardanaz, E., López, D.C., Sanchez, M.J., Quiróz, J.R., Amiano, P., Berglund, G.,
Manjer, J., Palmqvist, R., Guelpen, B. van, Allen, N., Key, T.J., Bingham, S, Mazuir, M., Boffetta, P.,
Kaaks, R. & Riboli, E. (2007). Lifetime and baseline alcohol intake and risk of colon and rectal cancers
in the European prospective investigation into cancer and nutrition (EPIC). International Journal of
Cancer, 121(9), 2065-2072.
85 Fischer, K., Grobbee, D.E. & Berg, H.M. van den (2007). RCTs and observational studies to determine
the effect of prophylaxis in severe haemophilia. Haemophilia, 13(4), 345-350.
86 Fransen, G.A., Marrewijk, C.J. van, Mujakovic, S., Muris, JW, Laheij, R.J., Numans, M.E., Wit, N.J. de,
Samson, M., Jansen, J.B. & Knottnerus, J.A. (2007). Pragmatic trials in primary care. Methodological
challenges and solutions demonstrated by the DIAMOND-study. BMC Medical Research
Methodology [E], 7, 7-16.
87 Friedenreich, C.M., Cust, A., Lahmann, P.H., Steindorf, K., Boutron-Ruault, M.C., Clavel-Chapelon,
F., Mesrine, S., Linseisen, J., Rohrmann, S., Boeing, H., Pischon, T., Tjonneland, A., Halkjaer, J.,
Overvad, K., Mendez, M., Redondo, M.L., Garcia, C.M., Larranaga, N., Tormo, M.J., Gurrea, A.B.,
Bingham, S, Khaw, K.T., Allen, N., Key, T.J., Trichopoulou, A., Vasilopoulou, E., Trichopoulos, D., Pala,
V., Palli, D., Tumino, R., Mattiello, A., Vineis, P., Bueno de Mesquita, H.B., Peeters, P.H.M., Berglund,
G., Manjer, J., Lundin, E., Lukanova, A., Slimani, N., Jenab, M., Kaaks, R. & Riboli, E. (2007).
Anthropometric factors and risk of endometrial cancer: the European prospective investigation into
cancer and nutrition. Cancer Causes & Control, 18(4), 399-413.
88 Friedenreich, C.M., Cust, A., Lahmann, P.H., Steindorf, K., Boutron-Ruault, M.C., Clavel-Chapelon,
F., Mesrine, S., Linseisen, J., Rohrmann, S., Pischon, T., Schulz, M., Tjonneland, A., Johnsen, N.F.,
Overvad, K., Mendez, M., Arguelles, M.V., Garcia, C.M., Larranaga, N., Chirlaque, M.D., Ardanaz, E.,
Bingham, S, Khaw, K.T., Allen, N., Key, T.J., Trichopoulou, A., Dilis, V., Trichopoulos, D., Pala, V.,
Tumino, R., Panico, S., Vineis, P., Bueno de Mesquita, H.B., Peeters, P.H.M., Monninkhof, E.M.,
Berglund, G., Manjer, J., Slimani, N., Ferrari, P., Kaaks, R. & Riboli, E. (2007). Physical activity and risk
of endometrial cancer: The European prospective investigation into cancer and nutrition.
International Journal of Cancer, 121(2), 347-355.
89 Garde, E.M.W. van de, Oosterheert, J.J., Bonten, M.J.M., Kaplan, R.C. & Leufkens, H.G.M. (2007).
International classification of diseases codes showed modest sensitivity for detecting communityaquired pneumonia. Journal of Clinical Epidemiology, 60(8), 834-838.
90 Garde, E.M.W. van de, Souverein, P.C., Hak, E., Deneer, V.H.M., Bosch, J.M.M. van den & Leufkens,
H.G.M. (2007). Angiotensin-converting enzyme inhibitor use and protection against pneumonia in
patients with diabetes. Journal of Hypertension, 25(1), 235-239.
91 Geerts, C.C., Grobbee, D.E., Ent, C.K. van der, Jong, B.M. de, Zalm, M.M. van der, Putte-Katier, N.,
Kimpen, J.L.L. & Uiterwaal, C.S.P.M. (2007). Tobacco smoke exposure of pregnant mothers and
blood pressure in their newborns: results from the wheezing illnesses study Leidsche Rijn birth
cohort. Hypertension, 50(3), 572-578.
92 Gehring, U., Hoek, G., Heinrich, J., Giovannangelo, M., Nordling, E., Bellander, T., Gerritsen, J.,
Jongste, J.C. de, Smit, H.A., Wichmann, H.E., Wickman, M. & Brunekreef, B. (2007). Bacteria and
mould components in house dust and children’s allergic sensitisation. European Respiratory Journal,
29(6), 1144-1153.
93 Geijer, R.M.M., Sachs, A.P.E., Verheij, Th.J.M., Kerstjens, H.A.M., Kuyvenhoven, M.M. & Hoes, A.W.
(2007). Quality of life in smokers: focus on functional limitations rather than on lung function?
British Journal of General Practice, 57(539), 477-482.
94 Geleijnse, J.M., Witteman, J.C., Stijnen, T., Kloos, M.W., Hofman, A. & Grobbee, D.E. (2007). Sodium
and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam Study.
European Journal of Epidemiology, 22(11), 763-770.
95 Gemert, L. & Schuurmans, M.J. (2007). The NEECHAM Confusion Scale and the Delirium
Observation Screening Scale: predictive value and ease of use in clinical practice. Nursing, 29, 3-6.
96 Gent, R. van, Ent, C.K. van der, Essen-Zandvliet, L.E.M., Rovers, M.M., Kimpen, J.L.L., Meer, G. de &
Klijn, P.H. (2007). No differences in physical activity in (un)diagnosed asthma and healthy controls.
Pediatric pulmonology, 42(11), 1018-1023.
97 Gent, R. van, Ent, C.K. van der, Rovers, M.M., Kimpen, J.L.L., Essen-Zandvliet, L.E.M. & Meer, G. de
(2007). Excessive body weight is associated with additional loss of quality of life in children with
asthma. Journal of Allergy and Clinical Immunology, 119(3), 591-596.
98 Gent, R. van, Essen, L.E.M. van, Rovers, M.M., Kimpen, J.L.L., Ent, C.K. van der & Meer, G. de (2007).
Quality of life in children with undiagnosed and diagnosed asthma. European Journal of Pediatrics,
166(8), 843-848.
99 Gent, R. van, Essen-Zandvliet, L.E. van, Rovers, M.M., Kimpen, J.L.L., Meer, G. de & Ent, C.K. van der
(2007). Poor perception of dyspnoea in children with undiagnosed asthma. European Respiratory
Journal, 30(5), 887-891.
100 Gerlofs-Nijland, M.E., Bloemen, H.J., Leseman, D.L., John, A., Boere, F., Kelly, F.J., Mudway, I.S.,
Jimenez, A.A., Donaldson, K., Guastadisegni, C., Janssen, N.A.H., Brunekreef, B., Sandstrom, T., Bree,
L. van & Cassee, F.R. (2007). Toxicity of coarse and fine particulate matter from sites with contrasting
traffic profiles. Inhalation toxicology, 19(13), 1055-1069.
101 Giovannangelo, M., Gehring, U., Nordling, E., Oldenwening, M., Terpstra, G., Bellander, T., Hoek, G.,
Heinrich, J. & Brunekreef, B. (2007). Determinants of house dust endotoxin in three European
countries-the airallerg study. Indoor Air, 17(1), 70-79.
102 Giovannangelo, M., Gehring, U., Nordling, E., Oldenwening, M., Rijswijk, K. van, Wind, S. de, Hoek,
G., Heinrich, J., Bellander, T. & Brunekreef, B. (2007). Levels and determinants of beta (1-->3)glucans and fungal extracellular polysaccharides in house dust of (pre-)schoolchildres in three
European countries. Environment International, 33(1), 9-16.
103 Giovannangelo, M., Nordling, E., Gehring, U., Oldenwening, M., Bellander, T., Heinrich, J., Hoek, G.
& Brunekreef, B. (2007). Variation of biocontaminant levels within and between homes - the airallerg
study. Journal of Exposure Science and Environmental Epidemiology, 17(2), 134-140.
104 Goessens, B.M.B., Graaf, Y. van der, Olijhoek, J.K. & Visseren, F.L.J. (2007). The course of vascular
risk factors and the occurrence of vascular events in patients with symptomatic peripheral arterial
disease. Journal of Vascular Surgery, 45(1), 47-54.
105 Goessens, B.M.B., Visseren, F.L.J., Kappelle, L.J., Algra, A. & Graaf, Y. van der (2007). Asymptomatic
carotid artery stenosis and the risk of new vascular events in patients with manifest arterial disease.
The SMART Study. Stroke, 38(5), 1470-1475.
106 Goessens, B.M.B., Visseren, F.L.J., Kappelle, L.J., Algra, A. & Graaf, Y. van der (2007). Response to the
letter by Dr Cote (letter). Stroke, 38, e149-e149.
107 Gorter, P.M., Visseren, F.L.J., Algra, A. & Graaf, Y. van der (2007). The impact of site and extent of
clinically evident cardiovascular disease and atherosclerotic burden on new cardiovascular events in
patients with Type 2 diabetes. The SMART study. Diabetic Medicine, 24(12), 1352-1360.
180 Annual Report 2007
Publications 181
108 Gouw, S.C., Berg, H.M. van den, Cessie, S. le & Bom, J.G. van der (2007). Treatment characteristics
and the risk of inhibitor development: a multicenter cohort study among previously untreated
patients with severe hemophilia A. Journal of Thrombosis and Haemostasis, 5, 1383-1390.
109 Gouw, S.C., Bom, J.G. van der & Berg, H.M. van den (2007). Treatment-related risk factors of
inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study.
Blood, 109(11), 4648-4654.
110 Gouw, S.C., Bom, J.G. van der, Auerswald, G., Ettinghausen, C.E., Tedgard, U. & Berg, H.M. van den
(2007). Recombinant versus plasma-derived factor VIII products and the development of inhibitors
in previously untreated patients with severe hemophilia A: the CANAL cohort study. Blood, 109(11),
4693-4697.
111 Groenwold, R.H.H., Hoes, A.W. & Hak, E. (2007). Confounding in publications of observational
intervention studies. European Journal of Epidemiology, 22(7), 413-415.
112 Groot, M.H. de, Keijser, J. de, Neeleman, J., Kerkhof, A.C., Nolen, W.A. & Burger, H. (2007). Cognitive
behaviour therapy to prevent complicated grief among relatives and spouses bereaved by suicide:
cluster randomised controlled trial. BMJ - British Medical Journal, 334(7601), 994-999.
113 Haeck, I.M., Timmer-de Mik, L., Lentjes, E.G.W.M., Buskens, E., Hijnen, D.J., Guikers, C.L.H.,
Bruijnzeel - Koomen, C.A.F.M. & Bruin-Weller, M.S. de (2007). Low basal serum cortisol in patients
with severe atopic dermatitis: potent topical corticosteroids wrongfully accused. British Journal of
Dermatology, 156(5), 979-985.
114 Hafsteinsdottir, T.B., Kappelle, L.J., Grypdonck, M.H.F. & Algra, A. (2007). Effects of Bobath-based
therapy on depression, shoulder pain and health-related quality of life in patients after stroke. Journal
of Rehabilitation Medicine, 39(8), 627-632.
115 Hafsteinsdottir, T.B., Kruitwagen, C.L.J.J., Strijker, H., Wee, K. & Grypdonck, M.H.F. (2007). Assessing
quality of nursing care as a confounding variable in an outcome study on neurodevelopmental
treatment. Journal of nursing care quality, 22, 371-377.
116 Haiman, C.A., Dossus, L., Setiawan, V.W., Stram, D.O., Dunning, A.M., Thomas, G., Thun, M.J.,
Albanes, D., Altshuler, D., Ardanaz, E., Boeing, H., Buring, J.E., Burtt, N.P., Calle, E.E., Chanock, S.,
Clavel-Chapelon, F., Colditz, G., Cox, D.G., Feigelson, H.S., Hankinson, S.E., Hayes, R.B., Henderson,
B.E., Hirschhorn, J.N., Hoover, R., Hunter, D., Kaaks, R., Kolonel, L.N., LeMarchand, L., Lenner, P.,
Lund, E., Panico, S., Peeters, P.H.M., Pike, M.C., Riboli, E., Tjonneland, A., Travis, R.C., Trichopoulos,
D., Wacholder, S. & Ziegler, R. (2007). Genetic variation at the CYP19A1 locus predicts circulating
estrogen levels but not breast cancer risk in postmenopausal women. Cancer Research, 67(5), 18931897.
117 Hajer, G.R., Graaf, Y. van der, Olijhoek, J.K., Edlinger, M. & Visseren, F.L.J. (2007). Low plasma levels
of adiponectin are associated with low risk for future cardiovascular events in patients with clinical
evident vascular disease. American Heart Journal, 154(4), 750.e1-750.e7.
118 Hajer, G.R., Graaf, Y. van der, Olijhoek, J.K., Verhaar, M.C. & Visseren, F.L.J. (2007). Levels of
homocysteine are increased in metabolic syndrome patients but are not associated with an increased
cardiovascular risk, in contrast to patients without the metabolic syndrome. Heart, 93(2), 216-220.
119 Halkes, P.H.A. & Algra, A. (2007). Anticoagulants, aspirin and dipyridamole in the secondary
prevention of cerebral ischemia; which is the best for which patient? Cerebrovascular Diseases, 24,
107-111.
120 Hankey, G.J., Baker, R.I., Algra, A., Song, S. & e.a., - (2007). VITATOPs, the VITAmins TO Prevent
Stroke Trial: Rationale and design of a randomised trial of B-vitamin therapy in patients with recent
transient ischaemic attack or stroke (NCT00097669) (ISRCTN74743444). International Journal of
Stroke, 2(2), 144-150.
121 Happo, M.S., Salonen, R.O., Halinen, A.I., Jalava, P.I., Pennanen, A.S., Kosma, V.M., Sillanpaa, M.,
Hillamo, R., Brunekreef, B., Katsouyanni, K., Sunyer, J. & Hirvonen, M.R. (2007). Dose and time
dependency of inflammatory responses in the mouse lung to urban air coarse, fine, and ultrafine
particles from six European cities. Inhalation toxicology, 19(3), 227-246.
122 Heide, A. van der, Onwuteaka-Philipsen, B.D., Rurup, M.L., Buiting, H.M., Delden, J.J.M. van,
Hanssen-de Wolf, J.E., Janssen, A.G., Pasman, H.R., Rietjens, J.A.C., Prins, C.J., Deerenberg, I.M.,
Gevers, J.K.M., Maas, P.J. van der & Wal, G. van der (2007). End-of-life practices in the Netherlands
under the Euthanasia Act. New England Journal of Medicine, 356(19), 1957-1965.
123 Heijstek, M.W., Pileggi, G.C., Zonneveld-Huijssoon, E., Armbrust, W., Hoppenreijs, E.P.A.H.,
Uiterwaal, C.S.P.M., Kuis, W. & Wulffraat, N.M. (2007). Safety of measles, mumps and rubella
vaccination in juvenile idiopathic arthritis. Annals of the Rheumatic Diseases, 66(10), 1384-1387.
124 Heikens, E., Bonten, M.J.M. & Willems, R.J.L. (2007). Enterococcal surface protein Esp is important
for biofilm formation of Enterococcus faecium E1162. Journal of Bacteriology, 189(22), 8233-8240.
125 Hellingman, C.A., Bergh, W.M. van den, Beijer, I.S., Dijk, G.W. van, Algra, A., Gijn, J. van & Rinkel,
G.J.E. (2007). Risk of rebleeding after treatment of acute hydrocephalus in patients with aneurysmal
subarachnoid hemorrhage. Stroke, 38(1), 96-99.
126 Hendrickx, A.P.A., Wamel, W.J.B. van, Posthuma, G., Bonten, M.J.M. & Willems, R.J.L. (2007). Five
genes encoding surface-exposed LPXTG proteins are enriched in hospital-adapted Enterococcus
faecium clonal complex 17 isolates. Journal of Bacteriology, 189(22), 8321-8332.
127 Henskens, L.H., Kroon, A.A., Schouw, Y.T. van der, Schiffers, P.M., Grobbee, D.E., Leeuw, P.W. de &
Bots, M.L. (2007). Renin-angiotensin system and nutric oxide synthase gene polymorphisms in
relation to stroke. American Journal of Hypertension, 20(7), 764-770.
128 Hjortnaes, J., Algra, A., Olijhoek, J.K., Huisman, A.M., Jacobs, J.W.G., Graaf, Y. van der & Visseren,
F.L.J. (2007). Serum Uric Acid Levels and Risk for Vascular Diseases in Patients with Metabolic
Syndrome. Journal of Rheumatology, 34(9), 1882-1887.
129 Hofhuis, J.G., Spronk, P., Stel, H.F. van, Schrijvers, A.J.P. & Bakker, J. (2007). Quality of life before
intensive care unit admission is a predictor of survival. Critical Care [E], 11(4), R78.
130 Hofmeijer, J., Amelink, G.J., Hertog, H. den, Algra, A., Kappelle, L.J., Worp, H.B. van der & HamletPais, Investigators (2007). Appreciation of the informed consent procedure in a randomised trial of
decompressive surgery for space occupying hemispheric infaction. Journal of Neurology,
Neurosurgery and Psychiatry, 78(10), 1124-1128.
131 Hogenhuis, J., Voors, A.A., Jaarsma, T., Hoes, A.W., Hillege, H.L., Kragten, J.A. & Veldhuisen, D.J. van
(2007). Anaemia and renal dysfunction are independently associated with BNP and NT-proBNP
levels in patientswith heart failure. European Journal of Heart Failure, 9(8), 787-794.
132 Hoogerduijn, J.G., Schuurmans, M.J., Duijnstee, M.S.H., Rooij, S.E. & Grypdonck, M.H.F. (2007). A
systematic review of predictors and screening instruments to identify older hospitalized patients at
risk for functional decline. Journal of clinical nursing, 16(1), 46-57.
133 Hopmans, T.E.M., Blok, H.E.M., Troelstra, A. & Bonten, M.J.M. (2007). Prevalence of hospitalacquired infections during successive surveillance surveys conducted at a university hospital in the
Netherlands. Infection control and hospital epidemiology, 28(4), 459-465.
134 Howard, S.C., Algra, A. & Rothwell, P.M. (2007). Effect of age and glycaemic control on the
association between fibrinogen and risk of acute coronary events after transient ischaemic attack or
stroke. Cerebrovascular Diseases, 25, 136-143.
135 Huddleston Slater, J.J., Lobbezoo, F., Onland-Moret, N.C. & Naeije, M. (2007). Anterior disc
displacement with reduction and symptomatic hypermobility in the human temporomandibular
joint: prevalence rates and risk factors in children and teenagers. Journal of orofacial pain, 21(1), 5562.
136 Huijbregts, H.J.T.A.M., Bots, M.L., Moll, F.L. & Blankestijn, P.J. (2007). Accelerated increase of
arteriovenous fistula use in haemodialysis centres: results of the multicentre CIMINO initiative.
Nephrology Dialysis Transplantation, 22(9), 2595-2600.
137 Huijbregts, H.J.T.A.M., Bots, M.L., Moll, F.L. & Blankestijn, P.J. (2007). Hospital specific aspects
predominantly determine primary failure of hemodialysis arteriovenous fistulas. Journal of Vascular
Surgery, 45(5), 962-967.
182 Annual Report 2007
Publications 183
138 Ista, E., Dijk, M. van, Gamel, C.J., Tibboel, D. & Hoog, M. (2007). Withdrawal symptoms in children
after a long-term administration of sedatives and/or analgesics: a literature review. Assessment
remains troublesome. Intensive Care Medicine, 33(8), 1396-1406.
139 Jacobs, J.W.G., Nijs, R.N.J.T.L. de, Lems, W.F., Geusens, P.P., Laan, R.F., Huisman, A.M., Algra, A.,
Buskens, E., Hofbauer, L.C., Oostveen, A.C.M., bruyn, G.A., Dijkmans, B.A. & Bijlsma, J.W.J. (2007).
Prevention of glucocorticoid indiced osteoporosis with alendronate or alfacalcidol: relations of
change in bone mineral density, bone markers, and calcium homeostasis. Journal of Rheumatology,
34(5), 1051-1057.
140 Jacobs, M.A., Wijga, A.H., Brunekreef, B., Jongste, J.C. de, Baan, C.A., Kerkhof, M. & Smit, H.A.
(2007). Do parents who smoke underutilize health care services for their children? A cross sectional
study within the longitudianl PIAMA study. BMC Health Services Research, 7(83).
141 Jalava, P.I., Salonen, R.O., Pennanen, A.S., Halinen, A.I., Happo, M.S., Hillamo, R., Brunekreef, B.,
Katsouyanni, K., Sunyer, J. & Hirvonen, M.R. (2007). Heterogeneities in inflammatory and cytotoxic
responses of RAW 264.7 macrophage cell line to urban air coarse, fine, and ultrafine particles from six
European sampling campaigns. Inhalation toxicology, 19(3), 213-225.
142 Jansen, A.G.S.C., Sanders, E.A.M., Hoes, A.W., Loon, A.M. van & Hak, E. (2007). Influenza- and
respiratory syncytial virus-asscociated mortality and hospitalisations. European Respiratory Journal,
Dec;30(6), 1158-66.
143 Jansen, F.E., Huffelen, A.C. van, Algra, A. & Nieuwenhuizen, O. van (2007). Epilepsy surgery in
tuberous sclerosis: a systematic review. Epilepsia, 48(8), 1477-1484.
144 Janssen, P.G.H., Gorter, K.J., Davis, K., Wang, J & Girach, A. (2007). Screen detected subjects with
type 2 diabetes and impaired glucose tolerance have more adverse cardiovascular risk than subjects
with impaired fasting glucose especially when they are obese: The Addition Netherlands Study.
Primary Care Diabetes, 1(2), 69-74.
145 Janssen, P.G.H., Gorter, K.J., Stolk, R.P. & Rutten, G.E.H.M. (2007). Low yield of population-based
screening for Type 2 diabetes in the Netherlands: the ADDITION Netherlands study. Family Practice,
24(6), 555-561.
146 Jenab, M., Riboli, E., Cleveland, R.J., Norat, T., Rinaldi, S., Nieters, A., Biessy, C., Tjonneland, A.,
Olsen, A., Overvad, K., Gronbaek, H., Clavel-Chapelon, F., Boutron-Ruault, M.C., Linseisen, J.,
Boeing, H., Pischon, T., Trichopoulos, D., Oikonomou, E., Trichopoulou, A., Panico, S., Vineis, P.,
Berrino, F., Tumino, R., Masala, G., Peeters, P.H.M., Gils, C.H. van, Bueno de Mesquita, H.B., Ocke,
M.C., Lund, E., Mendez, M., Tormo, M.J., Barricarte, A., Martinez-Garcia, C., Dorronsoro, M., Quiros,
J.R., Hallmans, G., Palmqvist, R., Berglund, G., Manjer, J., Key, T.J., Allen, N.E., Bingham, S, Khaw,
K.T., Cust, A. & Kaaks, R. (2007). Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and
rectal cancers in the European Prospective Investigation into Cancer and Nutrition. International
Journal of Cancer, 121(2), 368-376.
147 Johansson, M., McKay, J.D., Wiklund, F., Rinaldi, S., Verheus, M., Gils, C.H. van, Hallmans, G., Balter,
K., Adami, H.O., Gronberg, H., Stattin, P. & Kaaks, R. (2007). Implications for prostate cancer of IGF1
genetic variation and circulating IGF1 levels. Journal of Clinical Endocrinology and Metabolism,
92(12), 4820-4826.
148 Jong, B.M. de, Ent, C.K. van der, Putte-Katier, N., Zalm, M.M. van der, Verheij, Th.J.M., Kimpen,
J.L.L., Numans, M.E. & Uiterwaal, C.S.P.M. (2007). Determinants of health care utilization for
respiratory symptoms in the first year of life. Medical Care, 45(8), 746-752.
149 Jongerden, I.P., Rovers, M.M., Grypdonck, M.H.F. & Bonten, M.J.M. (2007). Open and closed
endotracheal suction systems in mechanically ventilated intensive care patients: a meta-analysis.
Critical Care Medicine, 35(1), 260-270.
150 Kamphuis, M.H., Geerlings, M.I., Dekker, J.M., Giampaoli, S., Nissinen, A.M., Grobbee, D.E. &
Kromhout, D. (2007). Autonomic dysfunction: a link between depression and cardiovascular
mortality? The FINE Study. European Journal of Cardiovascular Prevention and Rehabilitation, 14(6),
796-802.
151 Kamphuis, M.H., Geerlings, M.I., Tijhuis, M.A., Giampaoli, S., Nissinen, A.M., Grobbee, D.E. &
Kromhout, D. (2007). Physical inactivity, depression, and risk of cardiovascular mortality. Medicine
and science ini sports exercise, 39(10), 1693-1699.
152 Karadag, B., Ege, M.J., Scheynius, A., Waser, M., Schram-Bijkerk, D., Hage, M. van, Pershagen, G.,
Brunekreef, B., Riedler, J., Braun-Fahrlander, C. & Mutius, E. von (2007). Environmental
determinants of atopic eczema phenotypes in relation to asthma and atopic sensitization. Allergy,
62(12), 1387-1393.
153 Kastelein, J.J., Leuven, S.I. van, Burgess, L., Evans, G.W., Kuivenhoven, J.A., Barter, P.J., Revkin, J.H.,
Grobbee, D.E., Riley, W.A., Shear, C.L., Duggan, W.T. & Bots, M.L. (2007). Effect of torcetrapib on
carotid atherosclerosis in familial hypercholesterolemia. New England Journal of Medicine, 356(16),
1620-1630.
154 Kastelein, J.J., Leuven, S.I. van, Evans, G.W., Riley, W.A., Revkin, J.H., Shear, C.L. & Bots, M.L. (2007).
Designs of RADIANCE 1 and 2: carotid ultrasound studies comparing the effects of tocetrapib/
atorvastatin with atorvastatin alone on atherosclerosis. Current Medical Research and Opinion, 23(4),
885-894.
155 Kaya, M.G., Arslan, F., Abaci, A., Heijden, G.J.M.G. van der, Timurkay - Nak, T. & Cengel, A. (2007).
Myocardial blush grade: a predictor for major adverse cardiac events after primary PTCA with stent
implantation for acute myocardial infarction. Acta Cardiologica, 62(5), 445-451.
156 Keulen, J.K. van, Kleijn, D.P.V. de, Oude Nijhuis, M.M., Busser, E., Velema, E., Fijnheer, R., Graaf, Y.
van der, Moll, F.L., Vries, J.P.P.M. de & Pasterkamp, G. (2007). Levels of extra domain A containing
fibronectin in human atherosclerotic plaques are associated with a stable plaque phenotype.
Atherosclerosis, 195(1), 83-91.
157 Kim, J.Y., Burnett, R.T., Neas, L., Thurston, G.D., Schwartz, J., Tolbert, P.E., Brunekreef, B., Goldberg,
M.S. & Romieu, I. (2007). Panel discussion review: session two - interpretation of observed
associations between multiple ambient air pollutants and health effects in epidemiologic analyses.
Journal of Exposure Science and Environmental Epidemiology, 17(S2), S83-S89.
158 Klazen, C.A.H., Verhaar, H.J.J., Lampmann, L.E.H., Juttmann, J.R., Blonk, M.C., Jansen, F.H., Tielbeek,
A.V., Schoemaker, M.C., Buskens, E., Graaf, Y. van der, Janssens, X., Fransen, H., Everdingen, K.J. van,
Muller, A.F., Mali, W.P.T.M. & Lohle, P.N.M. (2007). VERTOS II: Percutaneous vertebroplasty versus
conservative therapy in patients with painful osteoporotic vertebral compression fractures; rationale,
objective and design of a multicenter randomized controlled trial. Trials [E], 8(1), 33-33.
159 Klijn, P.H., Baan-Slootweg, O.H. van der & Stel, H.F. van (2007). Aerobic exercise in adolescents with
obesity: preliminary evaluation of a modular training program and the modified shuttle test. BMC
Pediatrics, 7(19).
160 Knol, M.J., Geerlings, M.I., Egberts, A.C.G., Gorter, K.J., Grobbee, D.E. & Heerdink, E.R. (2007). No
increased incidence of diabetes in antidepressant users. International Clinical Psychopharmacology,
22(6), 382-386.
161 Knol, M.J., Heerdink, E.R., Egberts, A.C.G., Geerlings, M.I., Gorter, K.J., Numans, M.E., Grobbee,
D.E., Klungel, O.H. & Burger, H (2007). Depressive symptoms in subjects with diagnosed and
undiagnosed Type 2 diabetes. Psychosomatic Medicine: Journal of the American Psychosomatic
Society, 69(4), 300-305.
162 Knol, M.J., Tweel, I. van der, Grobbee, D.E., Numans, M.E. & Geerlings, M.I. (2007). Estimating
interaction on an additive scale between continuous determinants in a logistic regression model.
International journal of epidemiology, 36(5), 1111-1118.
163 Koek, H.L., Kardaum, J.W., Gevers, E., Bruin, A. de, Reitsma, J.B., Grobbee, D.E. & Bots, M.L. (2007).
Acute myocardial infarction incidence and hospital mortality: routinely collected national data versus
linkage of national registers. European Journal of Epidemiology, 22(11), 755-762.
184 Annual Report 2007
Publications 185
164 Koek, H.L., Soedamah - Muthu, S.S., Kardaun, J.W., Gevers, E., Bruin, A. de, Reitsma, J.B., Bots, M.L.
& Grobbee, D.E. (2007). Short- and long-term mortality after acute myocardial infarction:
comparison of patients with and without diabetes mellitus. European Journal of Epidemiology,
22(12), 883-888.
165 Koerselman, J., Jaegere, P.P.T. de, Verhaar, M.C., Grobbee, D.E. & Graaf, Y. van der (2007). Coronary
collateral circulation: The effects of smoking and alcohol. Atherosclerosis, 191(1), 191-198.
166 Koopman, L., Heijden, G.J.M.G. van der, Glasziou, P.P., Grobbee, D.E. & Rovers, M.M. (2007). A
systematic review of analytical methods used to study subgroups in (individual patient data) metaanalyses. Journal of Clinical Epidemiology, 60(10), 1002-1009.
167 Kreijkamp-Kaspers, S., Kok, L., Grobbee, D.E., Haan, E.H.F. de, Aleman, A. & Schouw, Y.T. van der
(2007). Dietary phytoestrogen intake and cognitive function in older women. Journals of Gerontology
Series A-Biological Sciences and Medical Sciences, 62(5), 556-562.
168 Krom, M. de, Schouw, Y.T. van der, Hendriks, J.C.J.M., Ophoff, R.A., Gils, C.H. van, Stolk, R.P.,
Grobbee, D.E. & Adan, R.A.H. (2007). Common genetic variations in CCK, leptin, and leptin
receptor genes are associated with specific human eating patterns. Diabetes, 56(1), 276-280.
169 Kroneman, M. & Essen, G.A. van (2007). Stagnating influenza vaccine coverage rates among high-risk
groups in Poland and Sweden in 2003/4 and 2004/5. Euro surveillance, 12(4), E1-E2.
170 Kroneman, M.W. & Essen, G.A. van (2007). Variations in influenza vaccination coverage among the
high-risk population in Sweden in 2003/4 and 2004/5: a population survey. BMC Public Health [E],
14(7), 113.
171 Kuijpers, T., Heijden, G.J.M.G. van der, Vergouwe, Y., Twisk, J.W. & Boeke, A.J.P. (2007). Good
generalizability of a prediction rule for prediction of persistent shoulder pain in the sort term. Journal
of Clinical Epidemiology, 60(9), 947-53.
172 Kuijpers, T., Vergouwe, Y., Heijden, G.J.M.G. van der, Bot, S.D., Twisk, J.W., Windt, D.A. van der &
Bouter, L.M. (2007). Generalizability of a prediction rule for sick leave due to shoulder pain. Scand J
Work Environ Health 2007, 33(6): 440-446.
173 Kuijpers, T., Windt, D.A.W.M. van der, Heijden, G.J.M.G. van der, Twisk, J & Vergouwe, Y. (2007). A
prediction rule for shoulder pain related sick leave: a prospective cohort study. BMC Musculoskeletal
Disorders [E], 7, 97-97.
174 Kwee, A., Bots, M.L., Visser, G.H.A. & Bruinse, H.W. (2007). Obstetric management and outcome of
pregnancy in women with a history of caesarean section in the Netherlands. European Journal of
Obstetrics, Gynecology and Reproductive Biology, 132(2), 171-176.
175 Laan, W., Selten, J.P.C.J., Grobbee, D.E., Smeets, H., Kahn, R.S. & Burger, H. (2007). Non-steroidal
anti-inflammatory drugs and the risk of psychosis. European Neuropsychopharmacology, 17(4), 309311.
176 Laat, E de, Schoonhoven, L., Grypdonck, M.H.F., Verbeek, A., Graaf, R. de, Pickers, P. van &
Achterberg, T. van (2007). Early postoperative 30 degrees lateral positionering after coronary artery
surgery: influence on cardiac output. Journal of clinical nursing, 16(4), 654-661.
177 Laat, M.W.M. de, Alderen, E.D. van, Franx, A., Visser, G.H.A., Bots, M.L. & Nikkels, P.G.J. (2007). The
umbilical coiling index in complicated pregnancy. European Journal of Obstetrics, Gynecology and
Reproductive Biology, 130(1), 66-72.
178 Lahmann, P.H., Friedenreich, C.M., Schuit, A.J., Salvini, S., Allen, N.E., Key, T.J., Khaw, K.T., Bingham,
S, Peeters, P.H.M., Monninkhof, E.M., Bueno de Mesquita, H.B., Wirfalt, E., Manjer, J., Gonzalez,
C.A., Ardanaz, E., Amiano, P., Quiros, J.R., Navarro, C., Martinez, C., Berrino, F., Palli, D., Tumino, R.,
Panico, S., Trichopoulou, A., Bamia, C., Trichopoulos, D., Boeing, H., Schulz, M., Linseisen, J., ChangClaude, J., Chapelon, F.C., Fournier, A., Boutron-Ruault, M.C., Tjonneland, A., Fons Johnson, N.,
Overvad, K., Kaaks, R. & Riboli, E. (2007). Physical activity and breast cancer risk: the European
Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology, Biomarkers & Prevention,
16(1), 36-42.
186 Annual Report 2007
In 2007, dr M.L. Bots managed to publish results from his research on the
effect of lipid modifying drugs on atherosclerosis progression in three
major journals: TheNew England Journal of Medicine, JAMA, and the
Lancet. In addition, he had also publication in the other top cardiovascular
journal such as Circulation, JACC, and Eur Heart Journal.
In the METEOR study statin treatment slowed progression of atherosclerosis, assesses as carotid intima-media thickness, in a population of healthy
men and women, free from previous vascular disease and diabetes and with
a low Framingham risk score (JAMA. 2007;297:1344-53). A multicenter international trial among familial hypercholesterolemia patients (RADIANCE I)
on the effect of increasing HDL cholesterol levels by cholesteryl ester transfer protein inhibitor on atherosclerosis progression showed no benefit of
the intervention (N Engl J Med. 2007;356:1620-30). Similar results were
found in RADIANCE II among patients mixed dyslipidemia (Lancet
2007;370:153-60).
Publications 187
179 Lanki, T., Ahokas, A., Alm, S., Janssen, N.A.H., Hoek, G., Hartog, J.J. de, Brunekreef, B. & Pekkanen, J.
(2007). Determinants of personal and indoor PM(2.5) and absorbance among elderly subjects with
coronary heart disease. Journal of Exposure Science and Environmental Epidemiology, 17(2), 124133.
180 Le, T., Rovers, M.M., Veenhoven, R.H., Sanders, E.A.M. & Schilder, A.G.M. (2007). Effect of
pneumococcal vaccination on otitis media with effusion in children older than 1 year. European
Journal of Pediatrics, 166, 1049-1052.
181 Le, T.M., Rovers, M.M., Staaij, B.K. van, Akker, E.H. van den & Schilder, A.G.M. (2007). Alterations
of the oropharyngeal microbial flora after adenotonsillectomy in children: a randomized controlled
trial. Archives of Otolaryngology - Head & Neck Surgery, 133(10), 969-972.
182 Leavis, H.L., Willems, R.J.L., Wamel, W.J.B. van, Schuren, F.H., Caspers, M.P. & Bonten, M.J.M.
(2007). Insertion Sequence-Driven Diversification Creates a Globally Dispersed Emerging
Multiresistant Subspecies of E. faecium. PLoS Pathogens, 3(1), e7-0075-e7-0096.
183 Linseisen, J., Rohrmann, S., Miller, A.B., Bueno de Mesquita, H.B., Buchner, F.L., Vineis, P., Agudo, A,
Gram, I.T., Janson, L., Krogh, V., Overvad, K., Rasmuson, T., Schulz, M., Pischon, T., Kaaks, R.,
Nieters, A., Allen, N.E., Key, T.J., Bingham, S, Khaw, K.T., Amiano, P., Barricarte, A., Martinez, C.,
Navarro, C., Quiros, R., Clavel-Chapelon, F., Boutron-Ruault, M.C., Touvier, M., Peeters, P.H.M.,
Berglund, G., Hallmans, G., Lund, E., Palli, D., Panico, S., Tumino, R., Tjonneland, A., Olsen, A.,
Trichopoulou, A., Trichopoulos, D., Autier, P., Boffetta, P., Slimani, N. & Riboli, E. (2007). Fruit and
vegetable consumption and lung cancer risk: Updated information from the European Prospective
Investigation into Cancer and Nutrition (EPIC). International Journal of Cancer, 121(5), 1103-1114.
184 Looijmans-van den Akker, I., Heuvel, P.M. van den, Verheij, Th.J.M., Delden, J.J.M. van, Essen, G.A.
van & Hak, E. (2007). No intention to comply with influenza and pneumococcal vaccination:
behavioural determinants among smokers and non-smokers. Preventive Medicine, 45(5), 380-385.
185 Looijmans-van den Akker, I., Delden, J.J.M. van & Hak, E. (2007). Uptake of influenza vaccination in
Dutch nursing home personnel following national recommendations. Journal of the American
Geriatrics Society, 55(9), 1486-1487.
186 Lorenz, M., Markus, H.S., Bots, M.L., Rosvall, M. & Sitzer, M. (2007). Prediction of clinical
cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis.
Circulation, 115(4), 459-467.
187 Maas, A.H., Schouw, Y.T. van der, Atsma, F., Beijerinck, D., Deurenberg, J.J.M., Mali, W.P.T.M. &
Graaf, Y. van der (2007). Breast arterial calcifications are correlated with subsequent development of
coronary artery calcifications, but their aetiology is predominantly different. European Journal of
Radiology, 63(3), 396-400.
188 Maas, A.H., Schouw, Y.T. van der, Beijerinck, D., Deurenberg, J.J.M., Mali, W.P.T.M., Grobbee, D.E. &
Graaf, Y. van der (2007). Vitamin K intake and calcifications in breast arteries. Maturitas, 56(3), 273279.
189 Madsen, C., Lodrup Carlsen, K.C., Oftedal, B., Hoek, G., Nafstad, P., Meliefste, K., Jacobsen, R.,
Nystad, W. & Brunekreef, B. (2007). Modeling the intra-urban variability of outdoor traffic pollution
in Oslo, Norway A GA2LEN project. Atmospheric Environment, 41(35), 7500-7511.
190 Maessen, M., Post, M.W.M., Maille, A.R., Lindeman, E., Mooij, R., Veldink, J.H. & Berg, L.H. van den
(2007). Validity of the Dutch version of the amyotrophic lateral sclerosis assessment questionnaire,
ALSAQ-40, ALSAQ-5. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 8(2), 96100.
191 Manschot, S.M., Biessels, G.J., Valk, H.W. de, Algra, A., Rutten, G.E.H.M., Grond, J. van der &
Kappelle, L.J. (2007). Metabolic and vascular determinants of impaired cognitive performance and
abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes. Diabetologia,
50(11), 2388-2397.
192 Manuguerra, M., Matullo, G., Veglia, F., Autrup, H., Dunning, A., Garte, S., Gormally, E., Malaveille,
C., Guarrera, S., Polidoro, S., Saletta, F., Peluso, M., Airoldi, L., Overvad, K., Raaschou-Nielsen, O.,
Clavel Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulos, D., Kalandidi, A., Palli, D., Krogh, V.,
Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Lund, E., Pera, G., Martinez, C.,
Amiano, P., Barricarte, A., Tormo, M.J., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E.,
Allen, N.E., Saracci, R., Kaaks, R., Ferrari, P., Riboli, E. & Vineis, P. (2007). Multi-factor dimensionality
reduction applied to a large prospective investigation on gene-gene and gene-environment
interactions. Carcinogenesis, 28(2), 414-422.
193 Masterton, R., Craven, D., Rello, J., Struelens, M., Frimodt-Moller, N., Chastre, J., Ortqvist, A.,
Cornaglia, G., Lode, H., Giamarellou, H., Bonten, M.J.M., Eraksoy, H. & Davey, P. (2007). Hospitalacquired pneumonia guidelines in Europe: a review of their status and future development. Journal of
Antimicrobial Chemotherapy, 60(2), 206-213.
194 Mauser-Bunschoten, E.P., Posthouwer, D., Fischer, K. & Berg, H.M. van den (2007). Safety and
efficacy of a plasma-derived monoclonal purified factor VIII concentrate during 10 years of followup. Haemophilia, 13(6), 697-700.
195 May, A.M., Weert, E. van, Korstjens, I., Hoekstra-Weebers, J.E., Schans, C.P. van der, Zonderland, M.L.,
Mesters, I., Borne, B.V. & Ros, W.J.G. (2007). Improved physical fitness of cancer survivors: A
randomised controlled trial comparing physical training with physical and cognitive-behavioural
training. Acta Oncologica, 5, 1-10.
196 Meijs, M.F.L., Bots, M.L., Vonken, E.P.A., Cramer, M.J.M., Melman, P.G., Velthuis, B.K., Graaf, Y. van
der, Mali, W.P.T.M. & Doevendans, P.A. (2007). Rationale and design of the SMART heart study: A
prediction model for left ventricular hypertrophy in hypertension. Netherlands Heart Journal, 15(9),
295-298.
197 Meijs, M.F.L., Windt, L.J. de, Jonge, N. de, Cramer, M.J.M., Bots, M.L., Mali, W.P.T.M. & Doevendans,
P.A.F.M. (2007). Left ventricular hypertrophy: a shift in paradigm. Current Medicinal Chemistry,
14(2), 157-171.
198 Meiland, R., Stolk, R.P., Geerlings, S.E., Peeters, P.H.M., Grobbee, D.E., Coenjaerts, F.E.J., Brouwer,
E.C. & Hoepelman, A.I.M. (2007). Association between Escherichia Coli bacteriuria and renal
function in women: long-term follow-up. Archives of Internal Medicine, 167(3), 253-257.
199 Metz, R., Kerkhoffs, G.M.M.J., Verleisdonk, E.J.M.M. & Heijden, G.J.M.G. van der (2007). Acute
achilles tendon rupture: minimally invasive surgery versus non operative treatment, with immediate
full weight bearing. Design of a randomized controlled trial. BMC Musculoskeletal Disorders [E],
8(1), 108-108.
200 Molenaar, E.A., Ameijden, E.J.C. van, Grobbee, D.E. & Numans, M.E. (2007). Comparison of routine
care self-supported and biometrical data on hypertension and diabetes: results of the Utrecht Health
Project. European Journal of Public Health, 17(2), 199-205.
201 Monninkhof, E.M., Elias, S.G., Vlems, F.A., Tweel, I. van der, Schuit, A.J., Voskuil, D.W. & Leeuwen,
F.E. van (2007). Physical activity and breast cancer: A systematic review. Epidemiology, 18(1), 137157.
202 Monninkhof, E.M., Peeters, P.H.M. & Schuit, A.J. (2007). Design of the sex hormones and physical
exercise (SHAPE) study. BMC Public Health [E], 7(1), 232.
203 Mosterd, A. & Hoes, A.W. (2007). Clinical epidemiology of heart failure. Heart, 93(9), 1137-1146.
204 Muller, M., Grobbee, D.E., Aleman, A., Bots, M.L. & Schouw, Y.T. van der (2007). Cardiovascular
disease and cognitive performance in middle-aged and elderly men. Atherosclerosis, 190(1), 143-149.
188 Annual Report 2007
Publications 189
205 Nagel, G., Linseisen, J., Boshuizen, H.C., Pera, G., Del Giudice, G., Westert, G.P., Bueno de Mesquita,
H.B., Allen, N.E., Key, T.J., Numans, M.E., Peeters, P.H.M., Sieri, S., Siman, H., Berglund, G.,
Hallmans, G., Stenling, R., Martinez, C., Arriola, L., Barricarte, A., Chirlaque, M.D., Quiros, J.R.,
Vineis, P., Masala, G., Palli, D., Panico, S., Tumino, R., Bingham, S, Boeing, H., Bergmann, M.M.,
Overvad, K., Boutron-Ruault, M.C., Clavel-Chapelon, F., Olsen, A., Tjonneland, A., Trichopoulou, A.,
Bamia, C., Soukara, S., Sabourin, J.C., Carneiro, F., Slimani, N., Jenab, M., Norat, T., Riboli, E. &
Gonzalez, C.A. (2007). Socioeconomic position and the risk of gastric and oesophageal cancer in the
European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). International
journal of epidemiology, 36(1), 66-76.
206 Nakhai Pour, H.R., Grobbee, D.E., Bots, M.L., Muller, M. & Schouw, Y.T. van der (2007). C-reactive
protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community.
Journal of human hypertension, 21(12), 949-955.
207 Nakhai Pour, H.R., Grobbee, D.E., Bots, M.L., Muller, M. & Schouw, Y.T. van der (2007). Circulating
homocysteine and large arterial stiffness and thickness in a population-based sample of middle-aged
and elderly men. Journal of human hypertension, 21(12), 942-948.
208 Nakhai Pour, H.R., Grobbee, D.E., Bots, M.L., Verhaar, H.J.J., Muller, M. & Schouw, Y.T. van der
(2007). Circulating sex hormone levels and aortic stiffness in men. Journal of the American Geriatrics
Society, 55(4), 621-622.
209 Nakhai Pour, H.R., Grobbee, D.E., Emmelot-Vonk, M.H., Bots, M.L., Verhaar, H.J.J. & Schouw, Y.T.
van der (2007). Oral testosterone supplementation and chronic low-grade inflammation in elderly
men: a 26-week randomized, placebo-controlled trial. American Heart Journal, 154(6), 1228-e1 - 7.
210 Nakhai Pour, H.R., Grobbee, D.E., Muller, M. & Schouw, Y.T. van der (2007). Association of
endogenous sex hormone with C-reactive protein levels in middle-aged and elderly men. Clinical
Endocrinology, 66(3), 394-398.
211 Niehoff, A.G., Haeften, T.W. van, Onland-Moret, N.C., Elbers, C.C., Wijmenga, C. & Schouw, Y.T.
van der (2007). C-Reactive protein is independently associated with glucose but not with insulin
resistance in healthy men. Diabetes Care, 30(6), 1627-1629.
212 Niermeijer, J.M.F., Eurelings, M., Linden, M.W. van der, Lokhorst, H.M., Franssen, H., Fischer, K.,
Teunissen, L.L., Berg, L.H. van den, Schobben, A.F.A.M., Wokke, J.H.J. & Notermans, N.C. (2007).
Intermittent cyclophosphamide with prednisone versus placebo for polyneuropathy with IgM
monoclonal gammopathy. Neurology, 69(1), 50-59.
213 Niesink, A., Trappenburg, J.C.A., Weert-van Oene, G.H. de, Lammers, J.W.J., Verheij, Th.J.M. &
Schrijvers, A.J.P. (2007). Systematic review of the effects of chronic disease management on qualityof-life in people with chronic obstructive pulmonary disease. Respiratory Medicine, 101(11), 22332239.
214 Norat, T., Dossus, L., Rinaldi, S., Overvad, K., Gronbaek, H., Tjonneland, A., Olsen, A., Clavel
Chapelon, F., Boutron-Ruault, M.C., Boeing, H.H., Lahmann, P.H., Linseisen, J., Nagel, G.,
Trichopoulou, A., Trichopoulos, D., Kalapothaki, V., Sieri, S., Palli, D., Panico, S., Tumino, R.,
Sacerdote, C., Bueno de Mesquita, H.B., Peeters, P.H.M., Gils, C.H. van, Agudo, A, Amiano, P.,
Ardanoz, E., Martinez, C., Quiros, R., Tormo, M.J., Bingham, S, Key, T.J., Allen, N.E., Ferrari, P.,
Slimani, N., Riboli, E. & Kaaks, R. (2007). Diet, serum insulin-like growth factor-I and IGF-binding
protein-3 in European women. European Journal of Clinical Nutrition, 61(1), 91-98.
215 Numans, M.E. (2007). Open-access upper GI endoscopy in the 21st century. Digestion, 75(4), 225226.
216 Oftedal, B., Brunekreef, B., Nystad, W. & Nafstad, P. (2007). Residential outdoor air pollution and
allergen sensitization in schoolchildren in Oslo, Norway. Clinical and Experimental Allergy, 37(11),
1632-1640.
217 Olijhoek, J.K., Graaf, Y. van der, Haffner, S.M. & Visseren, F.L.J. (2007). Defining the metabolic
syndrome: Resolving unresolved issues? European journal of internal medicine, 18(4), 309-313.
218 Onland-Moret, N.C., A, D.L. van der, Schouw, Y.T. van der, Buschers, W., Elias, S.G., Gils, C.H. van,
Koerselman, J., Roest, M., Grobbee, D.E. & Peeters, P.H.M. (2007). Analysis of case-cohort data: A
comparison of different methods. Journal of Clinical Epidemiology, 60(4), 350-355.
219 Opstelten, W. & Zaal, M.J. (2007). Hutchinson sign and herpes zoster. Otolaryngology - Head and
Neck Surgery, 136(6), 1027.
220 Opstelten, W., Zuithoff, N.P., Essen, G.A. van, Loon, A.M. van, Wijck, A.J.M. van, Kalkman, C.J.,
Verheij, Th.J.M. & Moons, K.G.M. (2007). Predicting postherpetic neuralgia in elderly primary care
patients with herpes zoster: Prospective prognostic study. Pain, 132(Suppl 1), S52-S59.
221 Opstelten, W., Loon, A.M. van, Schuller, M., Wijck, A.J.M. van, Essen, G.A. van, Moons, K.G.M. &
Verheij, Th.J.M. (2007). Clinical diagnosis of herpes zoster in family practice. Annals of Family
Medicine, 5(4), 305-309.
222 Opstelten, W., Loon, A.M. van, Wijck, A.J.M. van & Moons, K.G.M. (2007). Correlates of acute pain
in herpes zoster. Journal of Clinical Virology, 39, 238-239.
223 Opstelten, W., Wijck, A.J.M. van, Essen, G.A. van, Moons, K.G.M., Verheij, Th.J.M., Kalkman, C.J. &
Hout, B.A. van (2007). Cost effectiveness of epidural injection of steroids and local anesthetics for
relief of zoster-associated pain. Anesthesiology, 107(4), 678-679.
224 Orfanos, P., Naska, A., Trichopoulos, D., Slimani, N., Ferrari, P., Bakel, M. van, Deharveng, G,
Overvad, K., Tjonneland, A., Halkjaer, J., Santucci de Magistris, M., Tumino, R., Pala, V., Sacerdote, C.,
Masala, G., Skeie, G., Engeset, D., Lund, E., Jakszyn, P., Barricarte, A., Chirlaque, M.D., MartinezGarcia, C., Amiano, P., Quiros, J.R., Bingham, S., Welch, A., Spencer, E.A., Key, T.J., Rohrmann, S.,
Linseisen, J., Ray, J., Boeing, H., Peeters, P.H.M., Bueno de Mesquita, H.B., Ocke, M.C., Johansson, I.,
Johansson, G., Berglund, G., Manjer, J., Boutron-Ruault, M.C., Touvier, M., Clavel-Chapelon, F. &
Trichopoulou, A. (2007). Eating out of home and its correlates in 10 European countries. The
European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutrition,
10(12), 1515-1525.
225 Os-Medendorp, H. van, Eland-de Kok, P.C.M., Ros, W.J.G., Bruijnzeel-Koomen, C.A.F.M. &
Grypdonck, M.H.F. (2007). The nursing programme ‘Coping with itch’: a promising intervention for
patients with chronic pruritic skin diseases. Journal of clinical nursing, 16(7), 1238-1246.
226 Os-Medendorp, H. van, Ros, W.J.G., Eland-de Kok, P.C.M., Kennedy, C., Thio, B.H., Schuur-van der
Zande, A. van der, Grypdonck, M.H.F. & Bruijnzeel-Koomen, C.A.F.M. (2007). Effectiveness of the
nursing programme ‘Coping with itch’: a randomized controlled study in adults with chronic pruritic
skin disease. British Journal of Dermatology, 156(6), 1235-1244.
227 Palli, D., Masala, G., Del Giudice, G., Plebani, M., Basso, D., Berti, E., Numans, M.E., Ceroti, M.,
Peeters, P.H.M., Bueno de Mesquita, H.B., Buchner, F.L., Clavel-Chapelon, F., Boutron-Ruault, M.C.,
Krogh, V., Saieva, C., Vineis, P., Panico, S., Tumino, R., Nyren, O., Siman, H., Berglund, G., Hallmans,
G., Sanchez, M.J., Larranaga, N., Barricarte, A., Navarro, C., Quiros, J.R., Key, T.J., Allen, N., Bingham,
S, Khaw, K.T., Boeing, H., Weikert, C., Linseisen, J., Nagel, G., Overvad, K., Thomsen, R.W.,
Tjonneland, A., Olsen, A., Trichopoulou, A., Trichopoulos, D., Arvaniti, A., Pera, G., Kaaks, R., Jenab,
M., Ferrari, P., Nesi, G., Carneiro, F., Riboli, E. & Gonzalez, C.A. (2007). CagA+ Helicobacter pylori
infection and gastric cancer risk in the EPIC-EURGAST study. International Journal of Cancer,
120(4), 859-867.
228 Patel, A., MacMahon, S., Chalmers, J., Neal, B., Woodward, M., Billot, L., Harrap, S., Poulter, N.,
Marre, M., Cooper, M., Glasziou, P., Grobbee, D.E., Hamet, P., Heller, S., Liu, L.S., Mancia, G.,
Mogensen, C.E., Pan, C.Y., Rodgers, A. & Williams, B. (2007). Effects of a fixed combination of
perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2
diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet, 8;370(9590), 829-840.
190 Annual Report 2007
Publications 191
229 Peeters, P.H.M., Lukanova, A., Allen, N., Berrino, F., Key, T.J., Dossus, L., Rinaldi, S., Gils, C.H. van,
Bueno de Mesquita, H.B., Boeing, H., Schulz, M., Chang-Claude, J., Linseisen, J., Panico, S., Sacerdote,
C., Palli, D., Tumino, R., Trichopoulou, A., Trichopolos, D., Bamia, C., Larranaga, N., Ardanaz, E.,
Pera, G., Quiros, J.R., Martinez-Garcia, C., Navarro, C., Bingham, S, Khaw, K.T., Clavel, F.,
Tjonneland, A., Olsen, A., Overvad, K., Tetsche, M., Lund, E., Lundin, E., Berglund, G., Riboli, E. &
Kaaks, R. (2007). Serum IGF-I, its major binding protein (IGFBP-3) and epithelial ovarian cancer
risk: the European Prospective Investigation into Cancer and Nutrition (EPIC). Endocrine-related
Cancer, 14(1), 81-90.
230 Peeters, P.H.M., Slimani, N., Schouw, Y.T. van der, Grace, P.B., Navarro, C., Tjonneland, A., Olsen, A.,
Clavel-Chapelon, F., Touillaud, M., Boutron-Ruault, M.C., Jenab, M., Kaaks, R., Linseisen, J.,
Trichopoulou, A., Trichopoulos, D., Dilis, V., Boeing, H., Weikert, C., Overvad, K., Pala, V., Palli, D.,
Panico, S., Tumino, R., Vineis, P., Bueno de Mesquita, H.B., Gils, C.H. van, Skeie, G., Jakszyn, P.,
Hallmans, G., Berglund, G., Key, T.J., Travis, R.C., Riboli, E. & Bingham, S (2007). Variations in
plasma phytoestrogen concentrations in European adults. Journal of Nutrition, 137(5), 1294-1300.
231 Pera, M., Agudo, A, Bueno de Mesquita, H.B., Palli, D., Boeing, H., Carneiro, F., Berrino, F., Sacerdote,
C., Tumino, R., Panico, S., Berglund, G., Manjer, J., Johansson, I., Stenling, R., Martinez, C.,
Dorronsoro, M., Barricarte, A., Tormo, M.J., Quiros, J.R., Allen, N., Key, T.J., Bingham, S, Linseisen, J.,
Kaaks, R., Overvad, K., Jensen, M., Olsen, A., Tjonneland, A., Peeters, P.H.M., Numans, M.E., Ocke,
M.C., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Lund, E., Slimani, N., Jenab, M.,
Ferrari, P., Riboli, E. & Gonzalez, C.A. (2007). Cereal fiber intake may reduce risk of gastric
adenocarcinomas: The EPIC-EURGAST study. International Journal of Cancer, 121(7), 1618-1623.
232 Peters, H.G.M., Borel Rinkes, I.H.M., Mali, W.P.T.M., Bosch, M.A.A.J. van den, Storm, R.K., Plasier,
P.W., Boer, E. de, Overbeeke, A.J. van & Peeters, P.H.M. (2007). Breast MRI in nonpalpable breast
lesions: a randomized trial with diagnostic and therapeutic outcome - MONET - study. Trials [E],
8(1), 40-40.
233 Platenkamp, M., Hanlo, P.W., Fischer, K. & Gooskens, R.H.J.M. (2007). Outcome in pediatric
hydrocephalus: a comparison between previously used outcome measures and the hydrocephalus
outcome questionnaire. Journal of Neurosurgery, 107(1 Suppl.), 26-31.
234 Posthouwer, D., Fischer, K., Heusden, N. de & Mauser-Bunschoten, E.P. (2007). Pegylated interferon
and ribavirin combination therapy for chronic hepatitis C in patients with congenital bleeding
disorders: a single-centre experience. Haemophilia, 13, 98-103.
235 Posthouwer, D., Makris, M., Yee, T.T., Fischer, K., Veen, J.J. van, Griffioen, A., Erpecum, K.J. van &
Mauser-Bunschoten, E.P. (2007). Progression to end-stage liver disease in patients with inherited
bleeding disorders and hepatitis C: an international, multicenter cohort study. Blood, 109(9), 36673671.
236 Posthouwer, D., Mauser-Bunschoten, E.P., Fischer, K., Erpecum, K.J. van & Knegt, R.J. de (2007).
Significant liver damage in patients with bleeding disorders and chronic hepatitis C: non-invasive
assessment of liver fibrosis using transient elastography. Journal of Thrombosis and Haemostasis,
5(1), 25-30.
237 Posthouwer, D., Yee, T.T., Makris, M., Fischer, K., Griffioen, A., Veen, J.J. van & Mauser-Bunschoten,
E.P. (2007). Antiviral therapy for chronic hepatitis C in patients with inherited bleeding disorders: an
international, multicenter cohort study. Journal of Thrombosis and Haemostasis, 5, 1624-1629.
238 Prinssen, M., Buskens, E., Jong, S.E.C.A. de, Buth, J., Mackaay, A.J., Sambeek, M.R. & Blankensteijn,
J.D. (2007). Cost-effectiveness of conventional and endovascular repair of abdominal aortic
aneurysms: Results of a randomized trial. Journal of Vascular Surgery, 46(5), 883-890.
239 Pruissen, D.M.O., Gerritsen, S.A., Prinsen, T.J., Dijk, J.M., Kappelle, L.J. & Algra, A. (2007). Carotid
intima-media thickness is different in large- and small-vessel ischemic stroke: the SMART study.
Stroke, 38(4), 1371-1373.
240 Pruissen, D.M.O., Rosendaal, F.R., Gorter, J.W., Garcia, A., Kappelle, L.J. & Algra, A. (2007).
Haemostatic genetic variants, ABO blood group and bleeding risk during oral anticoagulant
treatment after cerebral ischaemia of arterial origin. Journal of Neurology, 254(12), 1660-1665.
241 Putte-Katier, N., Uiterwaal, C.S.P.M., Jong, B.M. de, Kimpen, J.L.L., Verheij, Th.J.M. & Ent, C.K. van
der (2007). The influence of maternal respiratory infections during pregnancy on infant lung
function. Pediatric pulmonology, 42(10), 945-951.
242 Putte, E.M. van de, Engelbert, R.H.H., Kuis, W., Kimpen, J.L.L. & Uiterwaal, C.S.P.M. (2007).
Alexithymia in adolescents with chronic fatigue syndrome. Journal of Psychosomatic Research, 63(4),
377-380.
243 Rademaker, K.J., Groenendaal, F., Bel, F. van, Vries, L.S. de & Uiterwaal, C.S.P.M. (2007). The DART
study of low-dose dexamethasone therapy. Pediatrics, 120(3), 689-691.
244 Rademaker, K.J., Uiterwaal, C.S.P.M., Groenendaal, F., Uniken Venema, M.M.A.T., Bel, F. van, Beek,
F.J., Haastert, I.C. van, Grobbee, D.E. & Vries, L.S. de (2007). Neonatal hydrocortisone treatment:
neurodevelopmental outcome and MRI at school age in preterm-born children. The Journal of
Pediatrics, 150(4), 351-357.
245 Ramadhani, M.K., Elias, S.G., Noord, P.A.H. van, Grobbee, D.E., Peeters, P.H.M. & Uiterwaal,
C.S.P.M. (2007). Innate handedness and disease-specific mortality in women. Epidemiology, 18(2),
208-212.
246 Regieli, J.J., Nathoe, H.M., Koerselman, J., Graaf, Y. van der, Grobbee, D.E. & Doevendans, P.A.F.M.
(2007). Coronary collaterals--insights in molecular determinants and prognostic relevance.
International Journal of Cardiology, 116(2), 139-143.
247 Rinaldi, S., Dossus, L., Lukanova, A., Peeters, P.H.M., Allen, N.E., Key, T.J., Bingham, S, Khaw, K.T.,
Trichopoulos, D., Trichopoulou, A., Oikonomou, E., Pera, G., Larranaga, N., Martinez-Garcia, C.,
Ardanaz, E., Quiros, J.R., Tormo, M.J., Tjonneland, A., Olsen, A., Overvad, K., Chang-Claude, J.,
Linseisen, J., Schulz, M., Boeing, H., Gils, C.H. van, Bueno de Mesquita, H.B., Pala, V., Palli, D., Panico,
S., Tumino, R., Vineis, P., Clavel-Chapelon, F., Mesrine, S., Boutron-Ruault, M.C., Lundin, E., Agren,
A., Berglund, G., Manjer, J., Kumle, M., Lund, E., Slimani, N., Saracci, R., Riboli, E. & Kaaks, R. (2007).
Endogenous androgens and risk of epithelial ovarian cancer: results from the European Prospective
Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiology, Biomarkers & Prevention,
16(1), 23-29.
248 Rodriguez Feo, J.A., Hellings, W.E., Verhoeven, B.A.N., Moll, F.L., Kleijn, D.P.V. de, Prendergast, J.,
Gao, Y., Graaf, Y. van der, Tellides, G., Sessa, W.C. & Pasterkamp, G. (2007). Low levels of Nogo-B in
human carotid atherosclerotic plaques are associated with an atheromatous phenotype, restenosis,
and stenosis severity. Arteriosclerosis, Thrombosis and Vascular Biology, 27(6), 1354-1360.
249 Roest, M., Himbergen, T.M. van, Barendrecht, A.B., Peeters, P.H.M., Schouw, Y.T. van der & Voorbij,
H.A.M. (2007). Genetic and environmental determinants of the PON-1 phenotype. European Journal
of Clinical Investigation, 37(3), 187-196.
250 Roest, M., Voorbij, H.A.M., Barendrecht, A.D., Peeters, P.H.M. & Schouw, Y.T. van der (2007). The
risk of acute ischaemic heart disease in post menopausal women depends on von Willebrand factor
and fibrinogen concentrations and blood group genotype. Thrombosis and Haemostasis, 5(1), 189191.
251 Rohrmann, S., Becker, N., Linseisen, J., Nieters, A., Rudiger, T., Raaschou-Nielsen, O., Tjonneland, A.,
Johnsen, H.E., Overvad, K., Kaaks, R., Bergmann, M.M., Boeing, H., Benetou, V., Psaltopoulou, T.,
Trichopoulou, A., Masala, G., Mattiello, A., Krogh, V., Tumino, R., Gils, C.H. van, Peeters, P.H.M.,
Bueno de Mesquita, H.B., Ros, M.M., Lund, E., Ardanaz, E., Chirlaque, M.D., Jakszyn, P., Larranaga,
N., Losada, A., Martinez-Garcia, C., Agren, A., Hallmans, G., Berglund, G., Manjer, J., Allen, N.E., Key,
T.J., Bingham, S, Khaw, K.T., Slimani, N., Ferrari, P., Boffetta, P., Norat, T., Vineis, P. & Riboli, E.
(2007). Fruit and vegetable consumption and lymphoma risk in the European Prospective
Investigation into Cancer and Nutrition (EPIC). Cancer Causes & Control, 18(5), 537-549.
192 Annual Report 2007
Publications 193
252 Rombout-Sestrienkova, E., Noord, P.A.H. van, Deursen, C.T. van, Sybesma, B.J., Nillesen-Meertens,
A.E. & Koek, G.H. (2007). Therapeutic erythrocytapheresis versus phlebotomy in the initial treatment
ofhereditary hemochromatosis - A pilot study. Transfusion and Apheresis Science, 36(3), 261-267.
253 Rooij, N.K. de, Linn, F.H.H., Plas, J.A., Algra, A. & Rinkel, G.J.E. (2007). Incidence of subarachnoid
haemorrhage: a systematic review with emphasis on region, age, gender and time trends. Journal of
Neurology, Neurosurgery and Psychiatry, 78, 1365-1372.
254 Roosbroeck, S.A.H. van, Jacobs, J.H., Janssen, N.A.H., Oldenwening, M., Hoek, G. & Brunekreef, B.
(2007). Long-term personal exposure to PM2.5, soot and NOx in children attending schools located
near busy roads, a validation study. Atmospheric Environment, 41(16), 3381-3394.
255 Rosmalen, J.G., Neeleman, J., Gans, R.O.B. & Jonge, P. de (2007). The association between
neuroticism and self-reported common somatic symptoms in a population cohort. Journal of
Psychosomatic Research, 62(3), 305-311.
256 Rovers, M.M., Glasziou, P., Appelman, C.L.M., Burke, P., McCormick, D.P., Damoiseaux, R.A.M.J.,
Little, P., Saux, N. Le & Hoes, A.W. (2007). Predictors of pain and/or fever at 3 to 7 days for children
with acute otitis media not treated initially with antibiotics: a meta-analysis of individual patient data.
Pediatrics, 119(3), 579-585.
257 Rutten, G.E.H.M. (2007). The nature of quality and the goals of diabetes care. Primary Care Diabetes,
1(2), 57-58.
258 Rutten, F.H., Cramer, M.J.M., Zuithoff, N.P., Lammers, J.W.J., Verweij, W., Grobbee, D.E. & Hoes,
A.W. (2007). Comparison of B-type natriuretic peptide assays for identifying heart failure in stable
elderly patients with a clinical diagnosis of chronic obstructive pulmonary disease. European Journal
of Heart Failure, 9(6-7), 651-659.
259 Rutten, G.E.H.M. & Munro, N. (2007). Primary care diabetes: Promoting research in primary care.
Primary Care Diabetes, 1(1), 1-2.
260 Sabour, S., Franx, A., Rutten, A., Grobbee, D.E., Prokop, M., Bartelink, M.L., Schouw, Y.T. van der &
Bots, M.L. (2007). High blood pressure in pregnancy and coronary calcification. Hypertension, 49(4),
813-817.
261 Sabour, S., Rutten, A., Schouw, Y.T. van der, Atsma, F., Grobbee, D.E., Mali, W.P.T.M., Bartelink,
M.E.L., Bots, M.L. & Prokop, W.M. (2007). Inter-scan reproducibility of coronary calcium
measurement using Multi Detector-Row Computed Tomography (MDCT). European Journal of
Epidemiology, 22(4), 235-243.
262 Sande, M van de, Dippenaar, H & Rutten, G.E.H.M. (2007). The relationship between patient
education and glycaemic control in a South African township. Primary Care Diabetes, 1(2), 87-92.
263 Sandstrom, T. & Brunekreef, B. (2007). Traffic exposure affects children’s lung development. Lancet,
369(9561), 535-537.
264 Santvoort, H.C. van, Besselink, M.G.H., Bollen, T.L., Buskens, E., Ramshorst, B. van & Gooszen, H.G.
(2007). Case-matched comparison of the retroperitoneal approach with laparotomy for necrotizing
pancreatitis. World journal of surgery, 31(8), 1635-1642.
265 Scheltens, T., Bots, M.L., Numans, M.E., Grobbee, D.E. & Hoes, A.W. (2007). Awareness, treatment
and control of hypertension: the ‘rule of halves’ in an era of risk-based treatment of hypertension.
Journal of human hypertension, 21(2), 99-106.
266 Scheltens, T., Bots, M.L., Numans, M.E., Grobbee, D.E. & Hoes, A.W. (2007). Erratum: Awareness,
treatment and control of hypertension: the ‘rule of halves’ in an era of risk-based treatment of
hypertension. Journal of human hypertension, 21(2), 182-182.
267 Scholtens, S., Brunekreef, B., Visscher, T.L., Smit, H.A., Kerkhof, M., Jongste, J.C. de, Gerritsen, J. &
Wijga, A.H. (2007). Reported versus measured body weight and height of 4-year-old children and the
prevalence of overweight. European Journal of Public Health, 17(4), 369-374.
268 Scholtens, S., Gehring, U., Brunekreef, B., Smit, H.A., Jongste, J.C. de, Kerkhof, M., Gerritsen, J. &
Wijga, A.H. (2007). Breastfeeding, weight gain in infancy, and overweight at seven years of age: the
prevention and incidence of asthma and mite allergy birth cohort study. American Journal of
Epidemiology, 165(8), 919-926.
269 Schonewille, W.J., Wijman, C.A.C., Michel, P., Algra, A. & Kappelle, L.J. (2007). The Basilar Artery
International Cooperation Study (BASICS). International Journal of Stroke, 2(3), 220-223.
270 Schoonhoven, L., Bousema, M.T. & Buskens, E. (2007). The prevalence and incidence of pressure
ulcers in hospitalised patients in The Netherlands: A prospective inception cohort study. International
Journal of Nursing Studies, 44(6), 927-935.
271 Schryver, E.L.L.M. de, Algra, A. & Gijn, J. van (2007). Dipyridamole for preventing stroke and other
vascular events in patients with vascular disease. The Cochrane Database of Systematic Reviews [E],
jul 18(3), CD001820.
272 Schulz, M., Nothlings, U., Allen, N., Onland-Moret, N.C., Agnoli, C., Engeset, D., Galasso, R., Wirfalt,
E., Tjonneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.C., Chajes, V., Clavel-Chapelon, F., Ray,
J., Hoffmann, K., Chang-Claude, J., Kaaks, R., Trichopoulos, D., Georgila, C., Zourna, P., Palli, D.,
Berrino, F., Tumino, R., Vineis, P., Panico, S., Bueno de Mesquita, H.B., Ocke, M.C., Peeters, P.H.M.,
Lund, E., Gram, I.T., Skeie, G., Berglund, G., Lundin, E., Hallmans, G., Gonzales, C.A., Quiros, J.R.,
Dorronsoro, M., Martinez, C., Tormo, M.J., Barricarte, A., Bingham, S, Khaw, K.T., Key, T.J., Jenab, M.,
Rinaldi, S., Slimani, N. & Riboli, E. (2007). No association of consumption of animal foods with risk
of ovarian cancer. Cancer Epidemiology, Biomarkers & Prevention, 16(4), 852-855.
273 Schurink, C.A.M., Visscher, S., Lucas, P.J.F., Leeuwen, H.J. van, Buskens, E., Hoff, R.G., Hoepelman,
I.M. & Bonten, M.J.M. (2007). A Bayesian decision-support system for diagnosing ventilatorassociated pneumonia. Intensive Care Medicine, 33(8), 1379-1386.
274 Selten, J.P.C.J., Veen, N.D., Hoek, H.W., Laan, W., Schols, D., Tweel, I. van der, Feller, W.G. & Kahn,
R.S. (2007). Early course of schizophrenia in a representative Dutch incidence cohort. Schizophrenia
Research, 97(1-3), 79-87.
275 Selten, J.P.C.J., Wierdsma, A., Mulder, N. & Burger, H. (2007). Treatment seeking for alcohol and drug
use disorders by immigrants to the Netherlands. Social Psychiatry and Psychiatric Epidemiology,
42(4), 301-306.
276 Setiawan, V.W., Schumacher, F.R., Haiman, C.A., Stram, D.O., Albanes, D., Altshuler, D., Berglund, G.,
Buring, J.E., Calle, E.E., Clavel-Chapelon, F., Cox, D.G., Gaziano, J.M., Hankinson, S.E., Hayes, R.B.,
Henderson, B.E., Hirschhorn, J.N., Hoover, R., Kaaks, R., Kolonel, L.N., Kraft, P., Ma, J., LeMarchand,
L., Linseisen, J., Lund, E., Navarro, C., Overvad, K., Palli, D., Peeters, P.H.M., Pike, M.C., Riboli, E.,
Stampfer, M.J., Thun, M.J., Travis, R.C., Trichopoulos, D., Yeager, M., Ziegler, R., Feigelson, H.S. &
Chanock, S.J. (2007). CYP17 Genetic Variation and Risk of Breast and Prostate Cancer from the
National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). Cancer
Epidemiology, Biomarkers & Prevention, 16(11), 2237-2246.
277 Sijmons, E.A., Lankveld, M.A.L., Witteveen, P.O., Peeters, P.H.M., Kuck-Koot, V.C.M. & Leeuwen, J.S.
van (2007). Compliance to clinical guidelines for early-stage epithelial ovarian cancer in relation to
patient outcome. European Journal of Obstetrics, Gynecology and Reproductive Biology, 131(2), 203208.
194 Annual Report 2007
Publications 195
278 Sinilnikova, O.M., McKay, J.D., Tavtigian, S.V., Canzian, F., DeSilva, D., Biessy, C., Monnier, S., Dossus,
L., Boillot, C., Gioia, L., Hughes, D.J., Jensen, M.K., Overvad, K., Tjonneland, A., Olsen, A., ClavelChapelon, F., Chajes, V., Joulin, V., Linseisen, J., Chang-Claude, J., Boeing, H., Dahm, S., Trichopoulou,
A., Trichopoulos, D., Koliva, M., Khaw, K.T., Bingham, S, Allen, N.E., Key, T.J., Palli, D., Panico, S.,
Berrino, F., Tumino, R., Vineis, P., Bueno de Mesquita, H.B., Peeters, P.H.M., Gils, C.H. van, Lund, E.,
Pera, G., Quiros, J.R., Dorronsoro, M., Martinez Garcia, C., Tormo, M.J., Ardanaz, E., Hallmans, G.,
Lenner, P., Berglund, G., Manjer, J., Riboli, E., Lenoir, G.M. & Kaaks, R. (2007). Haplotype-based
analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a casecontrol study nested within the European Prospective Investigation into Cancer and Nutrition.
Cancer Epidemiology, Biomarkers & Prevention, 16(3), 409-415.
279 Slimani, N., Deharveng, G, Unwin, I., Southgate, D.A., Vignat, J., Skeie, G., Salvini, S., Parpinel, M.,
Moller, A., Ireland, J., Becker, W., Farran, A., Westenbrink, S., Vasilopoulou, E., Unwin, J., Borgejordet,
A., Rohrmann, S., Church, S., Gnagnarella, P., Casagrande, C., Bakel, M. van, Niravong, M., BoutronRuault, M.C., Stripp, C, Tjonneland, A., Trichopoulou, A., Georga, K., Nilsson, S., Mattisson, I., Ray, J.,
Boeing, H., Ocke, M.C., Peeters, P.H.M., Jakszyn, P., Amiano, P., Engeset, D., Lund, E., Santucci de
Magistris, M., Sacerdote, C., Welch, A., Bingham, S, Subar, A.F. & Riboli, E. (2007). The EPIC nutrient
database project (ENDB): a first attempt to standardize nutrient databases across the 10 European
countries participating in the EPIC study. European Journal of Clinical Nutrition, 61(9), 1037-1056.
280 Smeets, H.M., Hoes, A.W. & Wit, N.J. de (2007). Effectiveness and costs of implementation strategies
to reduce acid suppressive drug prescriptions: a systematic review. BMC Health Services Research,
7(1), 177-177.
281 Speets, A.M., Graaf, Y. van der, Hoes, A.W., Kalmijn, S., Wit, N.J. de & Mali, W.P.T.M. (2007).
Expected and unexpected gallstones in primary care. Scandinavian Journal of Gastroenterology,
42(3), 351-355.
282 Stork, S.F.J., Bots, M.L., Angerer, P., Schacky, C. von, Grobbee, D.E., Angermann, C.E. & Seufert, J.
(2007). Low levels of adiponectin predict worsening of arterial morphology and function.
Atherosclerosis, 194(2), e147-e153.
283 Strien, T. van, Laar, F.A. van de, Leeuwe, J. van, Lucassen, P.L., Hoogen, H.J. van den, Rutten, G.E.H.M.
& Weel, C. van (2007). The dieting dilemma in patients with newly diagnosed type 2 diabetes: does
dietary restraint predict weight gain 4 years after diagnosis? Health Psychology, 26(1), 105-112.
284 Strozyk, D., White, L.R., Petrovitch, H., Geerlings, M.I., Remaley, A.T. & Launer, L.J. (2007). Sex
hormones and neuropathology in elderly men: The HAAS. Neurobiology of Aging, 28(1), 62-68.
285 Suarthana, E., Moons, K.G.M., Heederik, D.J.J. & Meijer, E. (2007). A simple diagnostic model for
ruling out pneumoconiosis among construction workers. Occupational and Environmental Medicine,
64, 595-601.
286 Sutedja, N.A., Sinke, R.J., Vught, P.W.J. van, Linden, M.W. van der, Wokke, J.H.J., Duijn, C.M. van,
Njajou, O.T., Schouw, Y.T. van der, Veldink, J.H. & Berg, L.H. van den (2007). The association
between H63D mutations in HFE and amyotrophic lateral sclerosis in a Dutch population. Archives
of Neurology, 64(1), 63-67.
287 Sutedja, N.A., Veldink, J.H., Fischer, K., Kromhout, H., Wokke, J.H.J., Huisman, M.H., Heederik, D.J.J.
& Berg, L.H. van den (2007). Lifetime occupation, education, smoking, and risk of ALS. Neurology,
69(15), 1508-1514.
288 Svirsevic, V., Passier, M.L., Nierich, A.P., Kalkman, C.J., Dijk, D. van & Heijden, G.J.M.G. van der
(2007). Epidural analgesia for cardiac surgery. In Epidural analgesia for cardiac surgery The Cochrane
Database of Systematic Reviews [E].
289 Thoolen, B.J., Ridder, D.T.D. de, Bensing, J., Gorter, K.J. & Rutten, G.E.H.M. (2007). Who participates
in diabetes self-management interventions?: Issues of recruitment and retainment. The Diabetes
Educator, 33(3), 465-474.
290 Tiehuis, A.M., Vincken, K.L., Mali, W.P.T.M., Kappelle, L.J., Anbeek, N., Algra, A. & Biessels, G.J.
(2007). Automated and visual scoring methods of cerebral white matter hyperintensities: relation
with age and cognitive function. Cerebrovascular Diseases, 25, 59-66.
291 Tits, L.J. van, Heerde, W.L. van, Vleuten, G.M. van der, Graaf, J. de, Grobbee, D.E., Vijver, L.P.L. van
de, Stalenhoef, A.F. & Princen, H.M.G. (2007). Plasma annexin A5 level relates inversely to the severity
of coronary stenosis. Biochemical and Biophysical Research Communications, 356(3), 674-680.
292 Tjang, Y.S., Hees, Y. van, Korfer, R., Grobbee, D.E. & Heijden, G.J.M.G. van der (2007). Predictors of
mortality after aortic valve replacement. European Journal of Cardio-Thoracic Surgery, 32(3), 469474.
293 Tjonneland, A., Christensen, J., Olsen, A., Stripp, C, Thomsen, B.L., Overvad, K., Peeters, P.H.M., Gils,
C.H. van, Bueno de Mesquita, H.B., Ocke, M.C., Thiebaut, A., Fournier, A., Clavel-Chapelon, F.,
Berrino, F., Palli, D., Tumino, R., Panico, S., Vineis, P., Agudo, A, Ardanaz, E., Martinez-Garcia, C.,
Amiano, P., Navarro, C., Quiros, J.R., Key, T.J., Reeves, G., Khaw, K.T., Bingham, S, Trichopoulou, A.,
Trichopoulos, D., Naska, A., Nagel, G., Chang-Claude, J., Boeing, H., Lahmann, P.H., Manjer, J.,
Wirfalt, E., Hallmans, G., Johansson, I., Lund, E., Skeie, G., Hjartaker, A, Ferrari, P., Slimani, N., Kaaks,
R. & Riboli, E. (2007). Alcohol intake and breast cancer risk: the European Prospective Investigation
into Cancer and Nutrition (EPIC). Cancer Causes & Control, 18(4), 361-373.
294 Top, J., Willems, R.J.L., Blok, H.E.M., Regt, M.J.A. de, Jalink, K., Troelstra, A., Goorhuis, B. & Bonten,
M.J.M. (2007). Ecological replacement of Enterococcus faecalis by multiresistant clonal complex 17
Enterococcus faecium. Clinical microbiology and infection, 13(3), 316-319.
295 Totlandsdal, A.I., Fudge, N., Sanderson, E.G., Bree, L. van & Brunekreef, B. (2007). Strengthening the
science-policy interface: experiences from a European thematic network on air pollution and health
(AIRNET). Environmental Science & Policy, 10(3), 260-266.
296 Trichopoulou, A., Bamia, C., Norat, T., Overvad, K., Schmidt, E.B., Tjonneland, A., Halkjaer, J., ClavelChapelon, F., Vercambre, M.N., Boutron-Ruault, M.C., Linseisen, J., Rohrmann, S., Boeing, H.,
Weikert, C., Benetou, V., Psaltopoulou, T., Orfanos, P., Boffetta, P., Masala, G., Pala, V., Panico, S.,
Tumino, R., Sacerdote, C., Bueno de Mesquita, H.B., Ocke, M.C., Peeters, P.H.M., Schouw, Y.T. van
der, Gonzalez, C., Sanchez, M.J., Chirlaque, M.D., Moreno, C., Larranaga, N., Guelpen, B. van,
Jansson, J.H., Bingham, S., Khaw, K.T., Spencer, E.A., Key, T.J., Riboli, E. & Trichopoulous, D. (2007).
Modified Mediterranean diet and survival after myocardial infarction: the EPIC-Elderly study.
European Journal of Epidemiology, 22(12), 871-881.
297 Uijl, S.G., Leijten, F.S.S., Arends, J.B., Parra, J, Huffelen, A.C. van & Moons, K.G.M. (2007). The added
value of [18F]-fluoro-D-deoxyglucose positron emission tomography in screening for temporal lobe
epilepsy surgery. Epilepsia, 48(11), 2121-2129.
298 Uiterwaal, C.S.P.M., Verschuren, W.M., Bueno de Mesquita, H.B., Ocke, M.C., Geleijnse, J.M.,
Boshuizen, H.C., Peeters, P.H.M., Feskens, E.J.M. & Grobbee, D.E. (2007). Coffee intake and
incidence of hypertension. American Journal of Clinical Nutrition, 85(3), 718-723.
299 Vaart, C.H. van der, Roovers, J.P.W.R., Leeuw, J.R.J. de & Heintz, A.P.M. (2007). Association between
urogenital symptoms and depression in community-dwelling women aged 20 to 70 years. Urology,
69(4), 691-696.
300 Vahedi, K., Hofmeijer, J., Juettler, E., Vicaut, E., George, B., Algra, A., Amelink, G.J., Schmiedeck, P.,
Schwab, S., Rothwell, P.M. & Decimal-Destiny-Hamlet, Investigators (2007). Assessing the benefits of
hemicraniectomy: what is a favourable outcome? - Authors’ reply. Lancet Neurology, 6(7), 580-581.
301 Vahedi, K., Hofmeijer, J., Juettler, E., Vicaut, E., George, B., Algra, A., Amelink, G.J., Schmiedeck, P.,
Schwab, S., Rothwell, P.M., Bousser, M.G., Worp, H.B. van der, Hacke, W. & Decimal-Destiny-Hamlet,
Investigators (2007). Early decompressive surgery in malignant infarction of the middle cerebral
artery: a pooled analysis of three randomised controlled trials. Lancet Neurology, 6(3), 215-222.
302 Vanderwee, K., Grypdonck, M.H.F. & Defloor, T. (2007). Non-blanchable erythema as an indicator
for the need for pressure ulcer prevention: a randomized controlled trial. Journal of clinical nursing,
16, 325-335.
196 Annual Report 2007
Publications 197
303 Vanderwee, K., Grypdonck, M.H.F., De, K.A. van & Defloor, T. (2007). Effectiveness of turning with
unequal time intervals on the incidence of pressure ulcer lesions. Journal of Advanced Nursing, 57,
59-68.
304 Veen, E.L. van der, Rovers, M.M., Albers, F.W.J., Sanders, E.A.M. & Schilder, A.G.M. (2007).
Effectiveness of trimethoprim/sulfamethoxazole for children with chronic active otitis media: a
randomized, placebo-controlled trial. Pediatrics, 119(5), 897-904.
305 Veldink, J.H., Kalmijn, S., Groeneveld, G.J., Wunderink, W., Koster, A., Vries, J.H. de, Wokke, J.H.J. &
Berg, L.H. van den (2007). Intake of polyunsaturated fatty acids and vitamin E reduces the risk of
developing amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 78(4),
367-371.
306 Veling, W.A., Selten, J.P.C.J., Susser, E., Laan, W., Mackenbach, J.P. & Hoek, H.W. (2007).
Discrimination and the incidence of schizophrenia among ethnic minorities in the Netherlands.
International journal of epidemiology, 36, 761-768.
307 Venmans-Muller, L.M.A.J., Sloof, M, Hak, E., Gorter, K.J. & Rutten, G.E.H.M. (2007). Prediction of
complicated urinary tract infections in patients with type 2 diabetes: a questionnaire study in primary
care. European Journal of Epidemiology, 22(1), 49-54.
308 Venmans-Muller, L.M.A.J., Gorter, K.J., Baard, K.P., Rutten, G.E.H.M. & Hak, E. (2007). Acceptibility
and effects of an educational leaflet on infections in type 2 diabetes patients: A randomized controlled
trial in primary care. Primary Care Diabetes, 1(3), 135-142.
309 Verberk, W.J., Kroon, A.A., Lenders, J.W., Kessels, A.G.H., Montfrans, G.A. van, Smit, A.J., Kuy, P.H.,
Nelemans, P.J., Rennenberg, R.J., Grobbee, D.E., Beltman, F.W., Joore, M.A., Brunenberg, D.E.,
Dirksen, C., Thien, T. & Leeuw, P.W. de (2007). Home versus office measurement, reduction of
unnecessary treatment study investigators. Self-measurement of blood pressure at home reduces the
need for antihypertensive drugs: a randomized, controlled trial. Hypertension, 50(6), 1019-1025.
310 Vergouwen, A.C., Burger, H., Koerselman, G.F. & Verheij, Th.J.M. (2007). Initial rate of improvement
in relation to remission of major depressive disorder in primary care. Journal of Clinical Psychiatry,
9(5), 364-366.
311 Verhaeghe, S., Zuuren, F.J. van, Defloor, T., Duijnstee, M.S.H. & Grypdonck, M.H.F. (2007). The
process and the meaning of hope for family members of traumatic coma patients in intensive care.
Qualitative health research, 17(6), 730-743.
312 Verhaeghe, S., Zuuren, F.J. van, Defloor, T., Duijnstee, M.S.H. & Grypdonck, M.H.F. (2007). How
does information influence hope in family members of traumatic coma patients in intensive care
unit? Journal of clinical nursing, 16, 1488-1497.
313 Verheus, M., Gils, C.H. van, Keinan-Boker, L., Grace, P.B., Bingham, S & Peeters, P.H.M. (2007).
Plasma phytoestrogens and subsequent breast cancer risk. Journal of Clinical Oncology, 25(6), 648655.
314 Verheus, M., Peeters, P.H.M., Kaaks, R., Noord, P.A.H. van, Grobbee, D.E. & Gils, C.H. van (2007).
Premenopausal insulin-like growth factor-I serum levels and changes in breast density over
menopause. Cancer Epidemiology, Biomarkers & Prevention, 16(3), 451-457.
315 Verheus, M., Peeters, P.H.M., Noord, P.A.H. van, Schouw, Y.T. van der, Grobbee, D.E. & Gils, C.H.
van (2007). No relationship between circulating levels of sex steroids and mammographic breast
density: the Prospect-EPIC cohort. Breast Cancer Research and Treatment, 9(4), R53.
316 Vernooij, F., Heintz, A.P.M., Witteveen, P.O. & Graaf, Y. van der (2007). The outcomes of ovarian
cancer treatment are better when provided by gynecologic oncologists and in specialized hospitals: a
systematic review. Gynecologic Oncology, 105(3), 801-812.
317 Verschuren, O.W., Ketelaar, M., Gorter, J.W., Helders, P.J.M., Uiterwaal, C.S.P.M. & Takken, T. (2007).
Exercise training program in children and adolescents with cerebral palsy: a randomized controlled
trial. Archives of pediatrics & adolescent medicine, 161(11), 1075-1081.
318 Vervoort, S.C.J.M., Borleffs, J.C.C., Hoepelman, A.I.M. & Grypdonck, M.H.F. (2007). Adherence in
antiretroviral therapy: a review of qualitative studies. AIDS, 21(3), 271-281.
319 Vineis, P., Hoek, G., Kryzanowski, M., Vigna-Taglianti, F., Veglia, F., Airoldi, L., Overvad, K.,
Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H., Trichopoulou, A., Palli, D., Krogh,
V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Lund, E.E., Agudo, A, Martinez,
C., Dorronsoro, M., Barricarte, A., Cirera, L., Quiros, J.R., Berglund, G., Manjer, J., Forsberg, B., Day,
N.E., Key, T.J., Kaaks, R., Saracci, R. & Riboli, E. (2007). Lung cancers attributable to environmental
tobacco smoke and air pollution in non-smokers in different European countries: a prospective study.
Environmental Health, 6, 7.
320 Vineis, P., Veglia, F., Garte, S., Malaveille, C., Matullo, G., Dunning, A., Peluso, M., Airoldi, L., Overvad,
K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Kaaks, R., Boeing, H., Trichopoulou, A.,
Palli, D., Crosignani, P.G., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Lund, E.,
Gonzalez, C., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, G.,
Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Riboli, E. & Autrup, H. (2007). Genetic susceptibility
according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in
nonsmokers. Annals of Oncology, 18(7), 1230-1242.
321 Visser, E., Pijl, Y.J., Stolk, R.P., Neeleman, J. & Rosmalen, J.G. (2007). Accident proneness, does it exist?
A review and meta-analysis. Accident Analysis & Prevention, 39(3), 556-564.
322 Vlimmeren, L.A. van, Graaf, Y. van der, Boere-Boonekamp, M.M., L’Hoir, M.P., Helders, P.J.M. &
Engelbert, R.H.H. (2007). Risk factors for deformational plagiocephaly at birth and at 7 weeks of age:
a prospective cohort study. Pediatrics, 119(2), e408-18.
323 Vollset, S.E., Igland, J., Jenab, M., Fredriksen, A., Meyer, K., Eussen, S., Gjessing, H.K., Ueland, P.M.,
Pera, G., Sala, N., Agudo, A., Capella, G., Del Giudice, G., Palli, D., Boeing, H., Weikert, C., Bueno de
Mesquita, H.B., Carneiro, F., Pala, V., Vineis, P., Tumino, R., Panico, S., Berglund, G., Manjer, J.,
Stenling, R., Hallmans, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R.,
Allen, N., Key, T.J., Bingham, S., Linseisen, J., Kaaks, R., Overvad, K., Tjonneland, A., Buchner, F.L.,
Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Lund,
E., Slimani, N., Ferrari, P., Riboli, E. & Gonzalez, C.A. (2007). The association of gastric cancer risk
with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the
European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology, Biomarkers &
Prevention, 16(11), 2416-2424.
324 Voormolen, M.H., Mali, W.P.T.M., Lohle, P.N., Fransen, H., Lampmann, L.E., Graaf, Y. van der,
Juttmann, J.R., Janssens, X. & Verhaar, H.J.J. (2007). Percutaneous vertebroplasty compared with
optimal pain medication treatment: short-term clinical outcome of patients with subacute or chronic
painful osteoporotic vertebral compression fractures. The VERTOS study. American Journal of
Neuroradiology, 28(3), 555-560.
325 Voort, T.Y.G. van der, Goossens, P.J.J. & Bijl, J.J. van der (2007). Burden, coping and needs for support
of caregivers for patients with a bipolar disorder: a systematic review. Journal of psychiatric and
mental health nursing, 14(7), 679-687.
326 Voskuil, D.W., Monninkhof, E.M., Elias, S.G., Vlems, F.A. & Leeuwen, F.E. van (2007). Physical
activity and endometrial cancer risk, a systematic review of current evidence. Cancer Epidemiology,
Biomarkers & Prevention, 16(4), 639-648.
327 Vries, A.C . de, Besselink, M.G.H., Buskens, E., Ridwan, B.U., Schipper, M., Erpecum, K.J. van &
Gooszen, H.G. (2007). Randomized controlled trials of antibiotic prophylaxis in severe acute
pancreatitis: relationship between methodological quality and outcome. Pancreatology, 7(5-6), 531538.
328 Wamel, W.J.B. van, Hendrickx, A.P.A., Bonten, M.J.M., Top, J., Posthuma, G. & Willems, R.J.L. (2007).
Growth condition dependent Esp expression by Enterococcus faecium affects initial adherence and
biofilm formation. Infection and Immunity, 75(2), 924-931.
198 Annual Report 2007
Publications 199
329 Waser, M., Michels, K.B., Bieli, C., Floistrup, H., Pershagen, G., Mutius, E. von, Ege, M., Riedler, J.,
Schram-Bijkerk, D., Brunekreef, B., Hage, M. van, Lauener, R. & Braun-Fahrlander, C. (2007). Inverse
association of farm milk consumption with asthma and allergy in rural and suburban population
across Europe. Clinical and Experimental Allergy, 37(5), 661-670.
330 Water, J.M. van de, Bergh, W.M. van den, Hoff, R.G., Algra, A. & Rinkel, G.J.E. (2007). Hypocalcaemia
may reduce the beneficial effect of magnesium treatment in aneurysmal subarachnoid haemorrhage.
Magnesium research, 20(2), 130-135.
331 Weber, S.G., Huang, S.S., Oriola, S., Huskins, W.C., Noskin, G.A., Harriman, K., Olmsted, R.N.,
Bonten, M.J.M., Lundstrom, T., Climo, M.W., Roghmann, M.C., Murphy, C.L. & Karchmer, T.B.
(2007). Legislative mandates for use of active surveillance cultures to screen for methicillin-resistant
Staphylococcus aureus and vancomycin-resistant enterococci: position statement from the Joint
SHEA and APIC Task Force. American journal of infection control, 35(2), 73-85.
332 Weber, S.G., Huang, S.S., Oriola, S., Huskins, W.C., Noskin, G.A., Harriman, K., Olmsted, R.N.,
Bonten, M.J.M., Lundstrom, T., Climo, M.W., Roghmann, M.C., Murphy, C.L. & Karchmer, T.B.
(2007). Legislative mandates for use of active surveillance cultures to screen for methicillin-resistant
Staphylococcus aureus and vancomycin-resistant enterococci: position statement from the Joint
SHEA and APIC Task Force. Infection control and hospital epidemiology, 28(3), 249-260.
333 Weert-van Oene, G.H. de, Burger, H., Grobbee, D.E. & Schrijvers, A.J.P. (2007). Identification of
patients at high risk of noncompliance in substance dependence treatment. European Addiction
Research, 13, 74-80.
334 Weert-van Oene, G.H. de, Burger, H., Grobbee, D.E. & Schrijvers, A.J.P. (2007). Indentification of
patients at high risk of noncompliance in substance dependence treatment. European Addiction
Research, 13(2), 74-80.
335 Weinmayr, G., Weiland, S.K., Bjorksten, B., Brunekreef, B., Buchele, G., Cookson, W.O., GarciaMarcos, L., Gotua, M., Gratziou, C., Hage, M. van, Mutius, E. von, Riikjarv, M.A., Rzehak, P., Stein,
R.T., Strachan, D.P., Tsanakas, J., Wickens, K. & Wong, G.W. (2007). Atopic sensitization and the
international variation of asthma symptom prevalence in children. American Journal of Respiratory
and Critical Care Medicine, 176(6), 565-574.
336 Wermer, M.J.H., Schaaf, I.C. van der, Algra, A. & Rinkel, G.J.E. (2007). Risk of rupture of unruptured
intracranial aneurysms in relation to patient and aneurysm characteristics: an updated meta-analysis.
Stroke, 38(4), 1404-1410.
337 Westerhuis, M.E.M.H., Moons, K.G.M., Bijvoet, S.M., Drogtrop, A., Geijn, H.P. van, Lith, J.M. van,
Mol, B.W.J., Nijhuis, J.G., Oei, S.G., Porath, M., Rijnders, R.J.P., Schuitemaker, N.W.E., Tweel, I van
der, Visser, G.H.A., Willekes, C. & Kwee, A. (2007). A randomised clinical trial on cardiotocography
plus fetal blood sampling versus cardiotocography plus ST-analysis of the fetal electrocardiogram
(STAN) for intrapartum monitoring. BMC Pregnancy and Childbirth, 7(13).
338 Wijk, I. van, Gorter, J.W., Lindeman, E., Kappelle, L.J., Gijn, J. van, Koudstaal, P.J. & Algra, A. (2007).
Mental status and health-related quality of life in an elderly population 15 years after limited cerebral
ischaemia. Journal of Neurology, 254(8), 1018-1025.
339 Willems, R.J.L. & Bonten, M.J.M. (2007). Glycopeptide-resistant enterococci: deciphering virulence,
resistance and epidemicity. Current Opinion in Infectious Diseases, 20(4), 384-390.
340 Windt, D.A.W.M. van der, Kuijpers, T., Jellema, A.P., Heijden, G.J.M.G. van der & Bouter, L.M. (2007).
Do psychological factors predict outcome in both low-back pain and shoulder pain? Annals of the
Rheumatic Diseases, 66(3), 313-319.
341 Winter, A.F. de, Heijden, G.J.M.G. van der, Scholten, R.J.P.M., Windt, D.A.W.M. van der & Bouter,
L.M. (2007). The Shoulder Disability Questionnaire differentiated well between high and low
disability levels in patients in primary care, in a cross-sectional study. Journal of Clinical
Epidemiology, 60(11), 1156-63.
200 Annual Report 2007
342 Zaane, B. van, Nierich, A.P., Buhre, W.F., Brando Bravo Huisman, G.J. & Moons, K.G.M. (2007).
Resolving the blind spot of transoesophageal echocardiography: a new diagnostic device for
visualizing the ascending aorta. British Journal of Anaesthesia, 98(4), 434-441.
343 Zijlstra, M., Dam, S.M. ten, Hulshof, P.J., Ram, C., Hiemstra, G. & Roos, N.M. de (2007). 24-hour
indirect calorimetry in mechanically ventilated critically ill patients. Nutrition in Clinical Practice,
2(22), 250-255.
344 Zonneveld-Huijssoon, E., Ronaghy, A., Rossum, M.A.J., Rijkers, G.T., Klis, F.R. van der, Sanders,
E.A.M., Vermeer-de Bondt, P.E., Hoes, A.W., Net, J. van der, Engels, C., Kuis, W., Prakken, B.J., Tol,
M.J.D. van & Wulffraat, N.M. (2007). Safety and efficacy of meningococcal c vaccination in juvenile
idiopathic arthritis. Arthritis and Rheumatism, 56(2), 639-646.
Professional Publications
Avendonk, M.J.P. van, Gorter, K.J., Donk, M. van den & Rutten, G.E.H.M. (2007). Niet alle
huisartsen hebben de praktijkorganisatie om optimale diabeteszorg te leveren. Huisarts en
Wetenschap, 50(11), 529-534.
2 Balen, J.A. van, Verduijn, M.M., Sachs, A.P.E., Berger, M.Y., Lucassen, P.L.B.J., Wiersma, T.J. &
Goudswaard, A.N. (2007). [Summary of the practice guideline ‘allergic and non-allergic rhinitis’ (first
revision) from the Dutch College of General Practitioners]. Nederlands Tijdschrift voor
Geneeskunde, 151(41), 2261-2265.
3 Beulens, J.W.J., Bots, M.L. & Grobbee, D.E. (2007). [Moderate alcohol consumption may be
recommended for the prevention of heartattacks]. Nederlands Tijdschrift voor Geneeskunde, 151(49),
2716-2716.
4 Bijl, J.J. van der & Djadoenath, L. (2007). Verpleegkundige Masteropleidingen aan de Academie
Gezondheidszorg Utrecht. Complementair en onderscheidend. Tijdschrift voor Ziekenverpleging, 5,
16-19.
5 Boomsma, L.J., Rovers, M.M., Balen, F.A.M. van, Wiersma, T. & Goudswaard, A.N. (2007). [The
practice guideline ‘Otitis media with effusion’ (second revision) from the Dutch College of General
Practitioners]. Nederlands Tijdschrift voor Geneeskunde, 151(4), 267-268.
6 Borleffs, C.J., Wilde, A.A. de, Bots, M.L., Kruyt, E. & Mosterd, A. (2007). Obductie redt levens.
Medisch Contact, 45, 1851-1853.
7 Bosman, M.M., Limmen, H. & Meijel, B.K.G. van (2007). Een spanningsmeter ter preventie van
zelfverwonding bij jongeren: ervaringen in de jeugdpsychiatrische hulpverlening. Psychopraxis, 9(2),
44-49.
8 Bots, M.L. & Dunselman, P.H.J.M. (2007). Gebruik van verandering in vaatwanddikte van de
halsslagader in trials naar effecten van geneesmiddelen. Cardio-Actueel, 12(2).
9 Bots, M.L. & Visseren, F.L.J. (2007). Interventieonderzoek met vasculaire geneesmiddelen: van
effecten op ziekte naar effecten op slagaderverkalking. Diabetes Actueel, 6(1).
10 Broekhuizen, B.D.L., Sachs, A.P.E., Hoes, A.W., Moons, K.G.M. & Verheij, Th.J.M. (2007).
Hoestklachten in de huisartspraktijk: een exacerbatie van COPD? Huisarts en Wetenschap, 50, 269.
11 Buiting, H.M., Delden, J.J.M. van, Rietjens, J.A.C., Onwuteaka-Philipsen, B.D., Bilsen, J., Fischer, S.,
Löfmark, R., Miccinesi, G., Norup, M. & Heide, A. van der (2007). Beslissingen over het afzien van
voeding en vocht bij stervende patiënten in zes Europese landen. Palliatieve Zorg, 8(1), 14-21.
12 Burgers, J.S., Simoons, M.L., Hoes, A.W., Stehouwer, C.D.A. & Stalman, W.A. (2007). [Guideline
‘Cardiovascular Risk Management’]. Nederlands Tijdschrift voor Geneeskunde, 151(19), 1068-1074.
1
Publications 201
13 Duijn, H.J. van, Kuyvenhoven, M.M., Butler, C., Coenen, S. & Verheij, Th.J.M. (2007). Variatie in
ambulant antibioticagebruik in drie Europese landen. Exploratie van mogelijke determinanten.
Huisarts nu, 36 (juni 2007), 246-248.
14 Duijn, H.J. van, Kuyvenhoven, M.M., Schellevis, F.G. & Verheij, Th.J.M. Groen slijm, witte stippen en
antibiotica. Huisarts en Wetenschap 2007; 50 (4): 150-5.
15 Geijer, R.M.M., Chavannes, N.H., Muris, J.W.M., Sachs, A.P.E., Schermer, T., Smeele, I.J.M., Thoonen,
B., Molen, T. van der, Schayck, C.P. van, Weel, C. van, Kolnaar, B.G.M. & Grol, M.H. (2007). NHG
Astma standaard. Huisarts en Wetenschap, 50(11), 537-551.
16 Geldorp, W.J. van, Numans, M.E., Berg, H.F., Putten, A.M. van, Scheele, M.E. & Bouma, M. NHGStandaard Virushepatitis en andere leveraandoeningen, tweede herziening. Huisarts en Wetenschap
2007;50(13):666-81.
17 Gent, R. van, Essen-Zandvliet, L.E. van, Rovers, M.M., Kimpen, J.L.L., Ent, C.K. van der & Meer, G. de
(2007). Kwaliteit van leven bij kinderen met niet gediagnosticeerd astma en gediagnosticeerd astma.
Medisch Journaal, 36(4), 189-193.
18 Gils, E.J.M. van, Veenhoven, R.H., Hak, E., Alphen, L. van, Hoitink, C.W.G., Ende, A. van der,
IJzerman, E.P.F., Schouls, L.M. & Sanders, E.A.M. (2007). Pneumokokkenconjugaatvaccinatie
Prevenar en onderzoek in Nederland. Tijdschrift voor Infectieziekten, 5(okt/nov), 173-181.
19 Gorter, K.J. & Romeijnders, A.C.M. (2007). De NHG-Standaard Jicht, reacties vanuit de reumatologie
en de huisartsgeneeskunde. Nederlands Tijdschrift voor Geneeskunde, 146, 872-873.
20 Gorter, K.J. (2007). Jaarlijkse voetscreening bij mensen met diabetes en wat kan je dan verder doen?
Tijdschrift voor praktijkondersteuning, 6, 190-193.
21 Graaf, Y. van der (2007). [The technology is ahead of the knowledge]. Nederlands Tijdschrift voor
Geneeskunde, 151(1), 36-38.
22 Grypdonck, M.H.F. (2007). Dokters-of verpleegkundige stoel? Mediator, 18(4), 12-13.
23 Grypdonck, M.H.F. (2007). Evidence Based Practice: een kritische beschouwing. Tijdschrift LVW,
7(2), 16-17.
24 Hafsteinsdottir, T.B., Algra, A., Kappelle, L.J. & Grypdonck, M.H.F. (2007). Neurodevelopmental
treatment following stroke: no beneficial effect shown in measurements taken after 1 year;
comparative study. Nederlands Tijdschrift voor Geneeskunde, 151(37), 2045-2049.
25 Haks, K., Bruijne, L.M. de & Ameijden, E.J.C. van (2007). Veranderingen in etnische
gezondheidsverschillen in de stad Utrecht in de periode 1995-2003. TSG, 85, 16-22.
26 Halkes, P.H.A., Gijn, J. van, Kappelle, L.J., Koudstaal, P.J., Algra, A. & ESPRIT Study, Group (2007).
Combinatie van acetylsalicylzuur en dipyridamol gunstig voor secundaire preventie na een ‘transient
ischaemic attack’ of een herseninfarct; een debat geeindigd. Nederlands Tijdschrift voor Geneeskunde,
150, 2671-2674.
27 Heide, A. van der, Onwuteaka-Philipsen, B.D., Rurup, M.L., Buiting, H.M., Delden, J.J.M. van,
Hanssen-de Wolf, J.E., Jansen, A.G.J.M., Pasman, H.R., Rietjens, J.A.C., Prins, C.J., Deerenberg, I.M.,
Gevers, J.K.M., Maas, P.J. van der & Wal, G. van der (2007). Medische beslissingen rond het
levenseinde in Nederland na de inwerkingtreding van de euthanasiewet. Nederlands Tijdschrift voor
Geneeskunde, 151, 1635-1642.
28 Hoekstra, J. & Meijel, B.K.G. van (2007). Choosing the Mental Health Care Field. A Study among
First-year Nursing Students. Maandblad Geestelijke Volksgezondheid, 62(11), 941-951.
29 Hoogerduijn, J.G., Buurman-van Es, B.M. & Schuurmans, M.J. (2007). Zorg voor oudere patiënten in
het ziekenhuis. Tijdschrift voor Ziekenverpleging, 9, 40-43.
30 Huisman, F.G. (2007). Het gezag van de expert. Marktwerking of gewogen oordeel? Karakter,
Tijdschrift van wetenschap, 19, 6-8.
31 Iestra, J.A. (2007). Implementatieonderzoek uitdaging voor studenten. Nederlands Tijdschrift voor
Voeding & Diëtetiek, 5(62), 20-22.
32 Jansen, A.G.S.C., Sanders, E.A.M., Loon, A.M. van, Hoes, A.W. & Hak, E. (2007). Griepvaccinatie:
herziening van de indicatiestelling. (Schatting van de sterfte en ziektelast door het influenzavirus en
het respiratoir syncytieel virus in Nederland gedurende 1997-2003: een epidemiologische
benadering.). Den Haag: Gezondheidsraad.
33 Kars, M.C. & Sulkers, E. (2007). Strategieën van ouders in de wetenschap dat hun kind zal overlijden
aan een progressieve neuro-degeneratieve spierziekte. Tijdschrift Kinderverpleegkunde, 13(1), 26.
34 Koek, H.L., Bruin, A. de, Gast, A., Gevers, E., Kardaun, J.W., Reitsma, J.B., Grobbee, D.E. & Bots, M.L.
(2007). Incidence of first acute myocardial infarction in the Netherlands. Netherlands Journal of
Medicine, 65(11), 434-441.
35 Koekkoek, B., Meijel, B.K.G. van & Hutschemakers, G. (2007). Moelijke psychiatrische patiënten. Een
overzicht van de literatuur. Maandblad Geestelijke Volksgezondheid, 62(2), 93-108.
36 Kuyvenhoven, M.M., Essen, G.A. van, Schellevis, G.G. & Verheij, Th.J.M. Behandeling van
bovensteluchtweginfecties met antibiotica in de Nederlandse Huisartspraktijk. Huisarts en
Wetenschap 2007; 50 (4): 139-43.
37 Lo, S.I., Swaans, I.J.E.M., Jong, B.J.B., Weert-van Oene, G.H. de & Schrijvers, A.J.P. (2007).
Visusbepaling bij kinderen vanaf 7 jaar op indicatie: goed gezien?! Tijdschrift voor
Jeugdgezondheidszorg, 2(39), 33-36.
38 Meijel, B.K.G. van (2007). Actueel: Competitie of samenwerking. Verpleegkunde, 22(2), 70-71.
39 Meijel, B.K.G. van (2007). Humor of schizofrenie. TVZ : Tijdschrift voor Verpleegkundigen, 117(9),
39.
40 Meijer, M, Meijel, B.K.G. van, Boer, F de & Bijl, J.J. van der (2007). Eenzaamheid bij mensen met
schizofrenie. Verpleegkunde, 22(2), 74-85.
41 Melker, R. de, Kuyvenhoven, M.M., Venekamp, R. & Damoiseaux, R. Vijftig jaar
bovensteluchtweginfecties. Huisarts en Wetenschap 207; 50(10): 478-82.
42 Nierop-van Baalen, C. & Grypdonck, M.H.F. (2007). Hoop doet leven. Een kwalitatief onderzoek
naar de rol van hoop bij patiënten met kanker die deelnemen aan fase-1 onderzoek. IKR Bulletin.
Tijdschrift van het Integraal Kankercentrum Rotterdam, juni 2007, 18-21.
43 Nijs, R.N.J.T.L. de, Jacobs, J.W.G., Lems, W.F., Laan, R.F., Algra, A., Huisman, A.M., Buskens, E, Laet,
C. de, Oostveen, J.C., Geusens, P.P., bruyn, G.A., Dijkmans, B.A. & Bijlsma, J.W.J. (2007). [Alendronate
more effective than alfacalcidol in the prevention of osteoporosis in patients with rheumatic disease
who are starting glucocorticoid therapy]. Nederlands Tijdschrift voor Geneeskunde, 151(21), 11781185.
44 Numans, M.E. (20-02-2007). Wat is de rol van een Helicobacter pylori infectie bij het ontstaan van
refluxziekte? Vademecum permanente nascholing huisartsen.
45 Opstelten, W., Steenbergen, J.E. van, Essen, G.A. van & Sande, M.A. van der (2007). [The use of
antiviral agents during an (impending) influenza pandemic]. Nederlands Tijdschrift voor
Geneeskunde, 151(18), 1008-1012.
46 Pel-Littel, R.E., D.G. Krouwel & Schuurmans, M.J. (2007). Voorkom een tweede val in het ziekenhuis.
TVZ : Tijdschrift voor Verpleegkundigen, 117(5), 44-47.
47 Peters, A., Thiesen, J., Schene, A.H. & Schrijvers, A.J.P. (2007). Zorgprogrammering in de GGZ zet
door. MGV : Maandblad Geestelijke Volksgezondheid, 6(62), 500-511.
48 Rooij, S.E., Buurman, B.M., Korevaar, J.C., Munster, B.C. van, Schuurmans, M.J., Laqaaij, A.M.,
Verhaar, H.J.J. & Levi, M. (2007). De betekenis van geriatrische syndromen en reeds bekende fysieke
beperkingen bij acuut in het ziekenhuis opgenomen oudere patiënten. Nederlands Tijdschrift voor
Geneeskunde, 151(36), 1987-1993.
49 Roos, N.M. de & Rijkers, G.T. (2007). Probiotica bij Cystic Fibrosis: volop keus, maar wat kies je? CFNieuws, 38(3), 20-25.
50 Roovers, J.P.W.R., Weenen, M., Bom, J.G. van der & Vaart, C.H. van der (2007). [Defecation
complaints after hysterectomy because of a benign condition are rare: a prospective study].
Nederlands Tijdschrift voor Geneeskunde, 151(22), 1239-1243.
202 Annual Report 2007
Publications 203
51 Rutten, A., Vos, A.M. de, Bots, M.L., Rensing, B.J., Cramer, M.J.M. & Prokop, W.M. (2007).
Multidetector computer tomografie van het hart. Gamma, 57(1), 3-8.
52 Rutten, G.E.H.M., Grauw, W.J.C. de, Bouma, M. & Goudswaard, A.N. (2007). Beperkte plaats voor
pioglitazon bij de behandeling van diabetes mellitus type 2. Huisarts en Wetenschap, 50(3), 118.
53 Sachs, A.P.E. & Grol, M.H. (2007). Samenvatting allergische en niet-allergische rhinitis. Nederlands
Tijdschrift voor Allergie, 2, 3-7.
54 Sachs, A.P.E. (2007). Kunnen inhalatiecorticosteroïden worden gebruikt in de zwangerschap?
Vademecum voor de huisarts, 25(13).
55 Sachs, A.P.E. (2007). Onderzoeksresultaten optimale behandeling ‘COPD’ in de huisartspraktijk.
Huisarts en Wetenschap, 50(12), 584-585.
56 Sachs, A.P.E. & Hoes, T. (2007). Rokers voor rokers. Het solidariteitsprincipe terug in de
ziektekostenverzekering. Medisch Contact, 27, 1165-1166.
57 Schrijvers, A.J.P. (2007). Californisch zorgmodel schoolvoorbeeld preventie. MedNet Magazine,
15(4), 25-25.
58 Schrijvers, A.J.P. (2007). Goede zorg, niet bij wet alleen... Tijdschrift voor
Gezondheidswetenschappen, 2(85), 12-13.
59 Schuurmans, M.J. (2007). Verbeteren van de medicatie-inname bij ouderen met polifarmacie.
Tijdschrift voor Ziekenverpleging, 117(2), 47.
60 Smeele, I.J.M., Weel, C. van, Schayck, C.P. van, Molen, T. van der, Thoonen, B., Schermer, T., Sachs,
A.P.E., Muris, J.W.M., Chavannes, N.H., Kolnaar, B.G.M., Grol, M.H. & Geijer, R.M.M. (2007). NHG
standaard COPD. Huisarts en Wetenschap, 50(8), 362-379.
61 Smit, M.C.A., Schothorst, A. van, Baar, M.E. van, Bie-de Waal, M.N.A. de, Meier, M. & Schrijvers,
A.J.P. (2007). De huisarts als poortwachter buiten kantoortijden. Tijdschrift voor
Gezondheidswetenschappen, 2(85), 115-115.
62 Steeman, E., Godderis, J., Grypdonck, M.H.F., De Bal, N. & Dierckx de Casterlé, B. (2007). Living
with dementia from the perspective of older people: Is it a positive story? Maandblad Geestelijke
Volksgezondheid, 62(2), 93-108.
63 Stringer, B., Meijel, B. van, Vree, W. de & Bijl, J.J. van der (2007). Patiëntenparticipatie in de GGZ. Een
literatuuronderzoek naar de mogelijkheden van verpleegkundigen. Maandblad Geestelijke
Volksgezondheid, 62(4), 290-302.
64 Thiel, G.J.M.W. van & Uniken Venema, M.M.A.T. (2007). Kind is geen volwassene. Niet therapeutisch
onderzoek schaadt de kleintjes. Medisch Contact, 62(29-30), 1251-1252.
65 Vaartjes, C.H., Peters, R.J.G., Dis, SJ van & Bots, M.L. (2007). Aangeboren hartafwijkingen. Cijfers en
feiten. Hart Bulletin, 38(6), 164-166.
66 Vaartjes, C.H., Peters, R.J.G., Dis, SJ van & Bots, M.L. (2007). Hartinfarct. Cijfers en feiten. Hart
Bulletin, 38(4), 112-114.
67 Vaartjes, C.H., Peters, R.J.G., Dis, SJ van & Bots, M.L. (2007). Sterfte aan hart- en vaatziekten en
kanker anno 2005. Cijfers en feiten. Hart Bulletin, 38(1), 29-31.
68 Vaartjes, C.H., Peters, R.J.G., Dis, SJ van & Bots, M.L. (2007). Ziekenhuisopnamen voor hart- en
vaatziekten. Feiten en cijfers. Hart Bulletin, 38(3), 85-86.
69 Ven, S.M.W.Y. van de, Elias, S.G., Luijten, P.R. & Mali, W.P.T.M. (2007). Optische beeldvorming van
de borst. Nederlands Tijdschrift voor Oncologie, 4(7), 299-307.
70 Vergouwen, A.C., Burger, H., Verheij, Th.J.M. & Koerselman, G.F. (2007). How can the results of
primary-care treatment for depression be improved? Tijdschrift voor Psychiatrie, 49(8), 559-567.
71 Vergouwen, A.C.M., Burger, H., Verheij, Th.J.M. & Koerselman, G.F. (2007). Hoe kunnen de
resultaten van de eerstelijnsbehandeling van depressie worden verbeterd? Tijdschrift voor Psychiatrie,
49, 555-558.
72 Verheij, Th.J.M. (2007). The practice guideline ‘Hearing impairment’ (first revision) from the Dutch
College of General Practitioners; a response from the perspective of general practice. Nederlands
Tijdschrift voor Geneeskunde, 151(8), 453.
204 Annual Report 2007
73 Verheus, M., Gils, C.H. van & Peeters, P.H.M. (2007). Fyto-oestrogenen en borstkanker. Tijdschrift
Kanker, 5, 10-12.
74 Verhoeven, M., Meijel, B. van, Winter, C.P. & Kars, M.C. (2007). Als de dood voor het leven: over
verpleegkundige zorg aan suïcidale patiënten. Verpleegkunde, 22(1), 8-18.
75 Verkade, P.J., Meijel, B. van, Brink, C., Schmitz, P. & Peijnenburg, R. (2007). Geagiteerd gedrag van
dementerende ouderen. TVZ : Tijdschrift voor Verpleegkundigen, 117(3), 38-41.
Books and Book Chapters
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Bynum, W.F., Bynum, H. & Huisman, F.G. (Eds.). (2007). Dictionary of Medical Biography (Editor 39
Lemma’s, from Rembertus Dodonaeus till Karel Wenckebach) (5 vols). Westport/London: Greenwood
Press.
Delden, J.J.M. van (2007). Euthanasie. In M. Becker, B. van Stokkum, P. van Tongeren & J.P. Wils
(Eds.), Lexicon van de ethiek (pp. 116-118). Assen: Van Gorcum.
Festen, H.P.M., Wit, N.J. de & Brouwers, J.R.B.J. (2007). Gastroenterologie. In Diagnose en Therapie
Jaarboek 2008. Houten: Bohn Stafleu van Loghum.
Gorgels, A.P.M., Rutten, F.H. & Tanks-Köhlen, B.C.M.J. (2007). Hart- en vaatziekten. In J.J.E. van
Everdingen & J.H. Glerum (Eds.), Diagnose en therapie. Jaarboek 2008 (pp. 180-217). Houten: Bohn
Stafleu van Loghum.
Gorter, K.J. (2007). Hielspoor/fasciitis plantaris. In J Eekhof, A Knuistingh Neven & W Opstelten
(Eds.), Kleine kwalen in de huisartspraktijk (pp. 756-759). Maarssen: Elsevier Gezondheidszorg.
Gorter, K.J. (2007). Tendinopathie van de achillespees. In J Eekhof, A Knuistingh Neven & W
Opstelten (Eds.), Kleine kwalen in de huisartspraktijk (pp. 752-755). Maarssen: Elsevier
Gezondheidszorg.
Graaf-Verhave, R. van der & Delden, J.J.M. van (2007). Ethische aspecten van medisch onderwijs. In
D. Engberts (Ed.), Ethiek en recht in de gezondheidszorg (pp. III119-III136). Antwerpen/Houten:
Bohn Stafleu Van Loghum.
Hene, R.J., Lock, M.T.W.T. & Pieters, H.M. (2007). Nefrologie/urologie. In J.J.E. van Everdingen &
J.H. Glerum (Eds.), Diagnose en Therapie, jaarboek 2008 (pp. 219-567). Houten: Bohn Stafleu van
Loghum.
Hoes, A.W. & Mosterd, A. (2007). Epidemiologie: prevalentie, incidentie en prognose. In A.A. Voors &
J.H. Kirkels (Eds.), Leerboek Hartfalen. Tweede, geheel herziene editie (pp. 29-45). Houten: Bohn
Stafleu Van Loghum.
Huisman, F.G. (2007). Abraham Hijmans van den Bergh. In W.F. Bynum & H. Bynum (Eds.),
Dictionary of Medical Biography (pp. 642-643). Westport/London: Greenwood Press.
Huisman, F.G. (2007). Franciscus dele Boë, Sylvius. In W.F. Bynum & H. Bynum (Eds.), Dictionary of
Medical Biography (pp. 1212-1213). Westport/London: Greenwood Press.
Huisman, F.G. (2007). Johannes van Loghem. In W.F. Bynum & H. Bynum (Eds.), Dictionary of
Medical Biography (pp. 808-809). Westport/London: Greenwood Press.
Huisman, F.G. (2007). Willem Einthoven. In W.F. Bynum & H. Bynum (Eds.), Dictionary of Medical
Biography (pp. 456-458). Westport/London: Greenwood Press.
Hurk, Th.A.M. van den & Louw, E.J.T.M. van der (2007). Dieetbehandelingsrichtlijn ketogeen dieet
voor kinderen met refractaire epilepsie. Evidence-based handleiding voor een multidisciplinaire
behandeling. Utrecht: UMC Utrecht, afdeling Diëtetiek.
Kneepkens, C.M.F. & Wit, N.J. de (2007). Chronische diarree. In Praktische Huisartsgeneeskunde,
deel Kindergeneeskunde. Houten: Bohn Stafleu van Loghum.
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16 Moons, K.G.M. & Burger, H. (2007). Designs voor observationeel onderzoek. In T. Plochg, R.E.
Juttmann, N.S. Klazinga & J.P. Mackenbach (Eds.), Handboek Gezondheidszorgonderzoek (pp. ---).
Houten: Bohn Stafleu van Loghum.
17 Neeleman, J. (2007). Epidemiologie van suïcidaal gedrag. In Handboek Suïcidaal gedrag (pp. 31-48).
Utrecht: de Tijdstroom.
18 Numans, M.E. & Smout, A.J.P.M. (2007). Dyspepsie. In J.W.M. Muris, E.M.H. Mathus-Vliegen &
Th.B. Voorn (Eds.), Gastroenterologie (Praktische Huisartsgeneeskunde) (pp. 38-50). Houten: Bohn
Stafleu Van Loghum.
19 Otten, M.H., Opstelten, W. & Asbeck, F.W.A. van (2007). Obstipatie bij neurologische aandoeningen.
In M.H. Otten (Ed.), De huisarts en het achterpoortje. Het spectrum van obstipatie (pp. 41-50).
Alphen a/d Rijn: Van Zuiden Communicaties BV.
20 Sachs, A.P.E. (2007). Astma en COPD handboek. Utrecht: Academic Pharmaceutical Productions.
21 Schrijvers, A.J.P., Baar, M.E. van, Ravelli, D P, Rosendal, H., Stel, H.F. van, Vrijhoef, H.J.M. & Weertvan Oene, G.H. de (2007). Onderzoek naar geïntegreerde zorg. In Juttmann.RE Klazinga NS Plochg T
(Ed.), Handboek gezondheidszorgonderzoek (pp. 296). 2007: Bohn Stafleu Van Loghum.
22 Thomas-Holtus, M.H.M., Klaassen, P.W.J. & Carbasius Weber, E.C. (2007). Eetstoornissen bij jonge
kinderen. In M. Former, G.A.E.G. van Asseldonk, J.J. van Duinen & R. van Nuland (Eds.), Dieetleer
(Informatorium voor Voeding en dietetiek, 67) (pp. XIVa-1-XIVa-14). Houten/Antwerpen: Bohn
Stafleu Van Loghum.
23 Vaartjes, C.H., Bakker, M.K. & Bots, M.L. (2007). Hart- en vaatziekten bij kinderen. In C.H. Vaartjes,
R.J.G. Peters, S.J. van Dis & M.L. Bots (Eds.), Hart- en vaatziekten in Nederland. Cijfers over leefstijlen risicofactoren, ziekte en sterfte (pp. 99-112). Den Haag: Nederlandse Hartstichting.
24 Vaartjes, C.H., Peters, R.J.G., Dis, SJ van & Bots, M.L. (2007). Hart- en vaatziekten in Nederland.
Cijfers over leefstijl- en risicofactoren, ziekte en sterfte. Den Haag: Nederlandse Hartstichting.
25 Vaartjes, C.H., Peters, R.J.G., Dis, SJ van & Bots, M.L. (2007). Hart- en vaatziekten in Nederland. In
C.H. Vaartjes, R.J.G. Peters, S.J. van Dis & M.L. Bots (Eds.), Hart- en vaatziekten in Nederland 2007,
cijfers over ziekte en sterfte (pp. 9-36). Den Haag: Nederlandse Hartstichting.
26 Vaartjes, C.H., Reitsma, J.B., Bruin, A. de & Bots, M.L. (2007). Kans op overlijden na een
ziekenhuisopname vanwege perifere arteriële vaatziekten. In C.H. Vaartjes, R.J.G. Peters, S.J. van Dis &
M.L. Bots (Eds.), Hart- en vaatziekten in Nederland 2007, cijfers over ziekte en sterfte (pp. 37-50).
Den Haag: Nederlandse Hartstichting.
27 Vaartjes, C.H., Reitsma, J.B., Bruin, A. de & Bots, M.L. (2007). Vergelijking van prognose van
patiënten met een eerste ziekenhuisopname wegens een acuut hartinfarct, een herseninfarct of
claudication intermittens in Nederland. In C.H. Vaartjes, R.J.G. Peters, S.J. van Dis & M.L. Bots (Eds.),
Hart- en vaatziekten in Nederland. Cijfers over leefstijl- en risicofactoren, ziekte en sterfte (pp. 51-59).
Den Haag: Nederlandse Hartstichting.
28 Wit, N.J. de & Matthus Vliegen, E.M.H. (2007). Obstipatie. In Praktische Huisartsgeneeskunde, deel
gastroenterologie. Houten: Bohn Stafleu en Loghum.
29 Wit, N.J. de, Rubin, G.D. & Jones, R. (2007). Irritable bowel syndrome. In Clinical evidence. BMJ.
206 Annual Report 2007
Publications 207
Nederlandse Samenvatting 2007
Annual Report Overview
Organisatie
Vanaf het ontstaan in 1996 is het Julius Centrum gegroeid zowel qua
grootte als qua werkgebied. Het Centrum is opgericht door het samenvoegen van de afdelingen Epidemiologie en Public Health en de verpleegafdeling van Klinische Epidemiologie. In 1999 werden de afdelingen Huisartsgeneeskunde en Patiënt-gericht Onderzoek toegevoegd. De
uiteindelijke toevoeging van de afdelingen Verplegingswetenschap en
Voedingswetenschappen in 2002 werd het huidige Julius Center for
Health Sciences and Primary Care.
Twee ontwikkelingen hebben plaatsgevonden binnen de organisatie in
2007. Er is een besluit genomen om te stoppen met
Verplegingswetenschap in de huidige vorm binnen de divisie. Daarnaast
zal vanaf medio 2008 het Centrum voor Biostatistiek van de Universiteit
Utrecht worden toegevoegd aan het Julius Centrum.
Onderzoek
Het onderzoek van het Julius Centrum valt binnen het UMC programma Epidemiologie. Binnen dit programma valt de voornaamste bijdrage
aan het totale onderzoek van het UMC Utrecht. Daarnaast draagt het
Julius Centrum bij aan de vier ziekte-gerelateerde onderzoeksgebieden
van het UMC Utrecht: hart- en vaatziekten, infectieziekten en immunologie, kanker en hersenen. Tot slot is het Julius Centrum ook betrokken
bij de twee andere methodologische onderzoeksthema’s van het UMC
Utrecht, te weten beeldwetenschappen en genomics.
Nederlandse Samenvatting 211
Onderzoek binnen het Julius Centrum is georganiseerd volgens een
matrixstructuur zoals die van het UMC Utrecht. Langs de horizontale as
de wetenschappelijke disciplines; Klinische Epidemiologie,
Huisartsgeneeskunde, MTA/Public Health/Medische Ethiek,
Verplegingswetenschap en Voedingswetenschappen. Langs de verticale as
staan de hierboven genoemde vier ziekte-gerelateerde onderzoekslijnen
met daaraan toegevoegd een methodologische onderzoekslijn.
multi-center trials, uitgevoerd door het Julius Centrum, onder andere
over het effect van lipid modifying drugs.
Het Julius Centrum is verantwoordelijk voor verschillende grote patiëntgebaseerde cohort onderzoeken zoals EPIC-NL en het Utrecht Health
Project. Daarnaast is het Julius Centrum betrokken bij de uitvoering van
grootschalige diagnostische onderzoeken die erop gericht zijn een vroege
ontdekking van hart- en vaatziekten te verbeteren.
Het Julius Centrum heeft formele banden met de volgende afdelingen/
groepen binnen de Universiteit Utrecht: het interfacultaire Institute for
Risk Assessment Sciences (IRAS), Environmental and Occupational
Epidemiology, farmaco-epidemiologie and veterinaire epidemiologie.
Infectieziekten
Onderzoek naar infectieziekten kan worden onderverdeeld in vijf gebieden:
1 Voorkomen, diagnose en prognose van infecties van de
ademhalingswegen
2 Doeltreffendheid van vaccinatiestrategieën
3 Mathematische modellen van infectieziekten
4 Infecties bij patiënten met diabetus mellitus
5 Effecten van ziekenhuisinfecties en de overdracht van antibioticaresistente bacterieën op patiënten
Het Julius Centrum geeft methodologisch advies en ondersteuning voor
klinisch onderzoek aan vrijwel alle afdelingen van het UMC. Stafleden
worden ingezet als adviseurs voor onderzoeksmethoden zowel binnen
als buiten het UMC Utrecht.
Onderzoeksthema’s
Hart- en Vaatziekten
Dit is de meest omvangrijke onderzoekslijn binnen het Julius Centrum.
Het meeste onderzoek richt zich op oorzaken, diagnose, prognose en
behandeling van hart- en vaatziekten. Epidemiologische onderzoeksmethoden, inclusief multi-centered randomized controlled trials, worden toegepast om de effecten van preventief en therapeutisch ingrijpen
te onderzoeken. De nadruk ligt op atherosclerose progressie als onderliggende oorzaak van ischemische vaatziekte.
In 2007 verschenen er publicaties in vooraanstaande publicaties zoals
JAMA en The Lancet over de resultaten van diverse grote internationale
212 Annual Report 2007
Kanker
Het kankeronderzoek binnen het Julius Centrum richt zich op de
oorzaak, vroege diagnose en prognose van hormoon-gerelateerde kanker, met name bij vrouwen. Het onderzoek naar de oorzaken richt zich
met name op de interactie tussen genen, hormonen en het milieu.
In 2007 werd Petra Peeters, hoofd van de kanker onderzoeksgroep, benoemd tot Professor of Chronic Disease Epidemiology aan de medische
faculteit van het Imperial College London in Londen, Verenigd
Koninkrijk.
Nederlandse Samenvatting 213
Geestelijke Gezondheid
Het onderdeel psychiatrische epidemiologie van het Julius Centrum
bestudeert psychiatrische ziekten en de daaraan gerelateerde comorbiditeit in eerstelijns zorg en de bevolking. Het onderzoek omvat de volgende drie gebieden;
1 Presentatie van depressie in eerstelijns zorg en de relatie met
lichamelijke ziekten zoals dementie, diabetes, maag-darmziekten en
2 Functionele ziekten en somatoforme aandoeningen
3 Psychiatrische morbiditeit gerelateerd aan sociodemografische
context en consultatie patronen.
De benadering van het bestuderen van het fenomeen somatische psychiatrische co-morbiditeit op verschillende niveau’s van het systeem van de
gezondheidszorg is uniek. De meeste onderzoeksprojecten worden uitgevoerd in samenwerking met partners in de eerstelijns- of tweedelijns
gezondheidszorg, en vaak in samenwerking met andere (internationale)
academische centra.
Theoretische Epidemiologie en Biostatistiek
Het Julius Centrum richt zich op het ontwikkelen van de theorie en
methodologie van epidemisch onderzoek. Theoretische epidemiologie
houdt zich bezig met onderzoek naar het verbeteren van bestaande
methoden en ontwikkelt innovatieve methoden voor de opzet en analyse
van epidemiologische studies.
IRAS
Het Institute for Risk Assessment Sciences (IRAS) is een interfacultair
onderzoeksinstituut binnen de Universiteit Utrecht dat zich bezighoudt
met interdisciplinair onderzoek dat zich richt op het vaststellen van risico’s van chemische, natuurlijke en biologische middelen op de gezond214 Annual Report 2007
heid. Dit onderzoek wordt uitgevoerd binnen drie divisies: Environ­
mental Epidemiology, Toxicology en Veterinary Public Health.
In 2007 werd het Utrecht Center of Molecular Epidemiology (UCME)
opgericht. Het centrum is een samenwerkingsverband tussen het IRAS
en het Julius Centrum en stelt core lab-faciliteiten ter beschikking voor
het faciliteren van handling van monsters, afname van DNA en een grote
diversiteit aan analytische technieken specifiek gericht op grootschalig
epidemiologisch onderzoek.
Internationale samenwerking
Onderzoek in het Julius Centrum wordt uitgevoerd in samenwerking
met onderzoeksinstituten en universiteiten in veel landen. Het centrum
richt zich met name op het ontwikkelen van intensieve structurele lange
termijn partnerships met strategisch geselecteerde vooraanstaande en
hoogwaardige academische instituten. Deze partnerships zijn van groot
belang bij het verwezenlijken van de ambitie van het Julius Centrum:
voorop blijven lopen in het internationaal gezondheidswetenschappelijk
onderzoek en het verspreiden van kennis onder een internationaal publiek van studenten en gezondheidsprofessionals.
De Academic Alliance for Clinical Trials is een academische onderzoekscontract organisatie die zich met name richt op de interactie tussen de
farmaceutische industrie en academische onderzoekers om zo innovatieve hoogwaardige fase III en fase IV clinical trials te stimuleren. Deze
alliantie is samengesteld uit een bestaand netwerk van klinieken en
gezondheidscentra verdeeld over vijf continenten.
De belangrijkste ontwikkeling in 2007 op het gebied van internationaal
onderwijs was de start van het AsiaLink project, gesubsidieerd door de
Europese Commissie. Het Julius Centrum, het Ministerie van
Nederlandse Samenvatting 215
Volksgezondheid in Maleisië en de University of Malaya Medical Center
(UMMC) in Kuala Lumpur, Maleisië ontwikkelen een steeds intensievere samenwerking.
Naast participatie in clinical trials neemt het Julius Centrum ook deel
aan het grootste lopende waarnemingsonderzoek op het gebied van
voeding en gezondheid in Europa, het EPIC onderzoek. Er is een nauwe
samenwerking tussen 23 kankeronderzoekscentra en public health instituten en universiteiten in heel Europa. Het nieuwe samenwerkingsproject EPIC-Heart levert baanbrekend epidemiologisch onderzoek naar de
oorzaken en gevolgen van hart- en vaatziekten waarbij gebruik wordt
gemaakt van gegevens en biologisch materiaal van 520.000 personen.
Externe beoordeling van onderzoeksresultaten
In 2007 werden de onderzoeksresultaten van het Julius Centrum beoordeeld door twee onafhankelijke externe beoordelingscommissies. De
eerste beoordeling maakte onderdeel uit van een waardering van alle
onderzoeksgroepen binnen het UMC Utrecht; de tweede beoordeling
maakte onderdeel uit van een waardering van alle onderzoeksgroepen
die betrokken waren bij het Nihes (Netherlands Institute of Health
Science). Deze tweede beoordeling vond plaats vanwege een hernieuwde
accreditatie van deze hogeschool door de Koninklijke Nederlandse
Academie van Wetenschappen (KNWA). Beide internationale commissies beoordeelden zowel de resultaten in het verleden als het toekomstperspectief als uitstekend.
Onderwijs
Het Julius Centrum neemt deel aan een grote hoeveelheid onderwijsprogramma’s in een breed scala aan gezondheidswetenschappen en eerstelijns zorg. Het centrum neemt actief deel aan nieuwe ontwikkelingen op
het gebied van onderwijs zoals het ambitieuze undergraduate medicine
program (CRU’99) van het UMC Utrecht, gestart in 1999 en gebaseerd
op interdisciplinair probleem-georiënteerd leren en aan SUMMA, een
nieuw 4-jarig master programma dat startte in 2004. Het merendeel van
de onderwijsprogramma’s wordt gegeven samen met andere divisies binnen of buiten het UMC Utrecht. Het centrum is de basis van het enige
Nederlandse universitaire masterprogramma voor verplegingswetenschap. Het centrum is onder andere ook verantwoordelijk voor de specialistenopleiding tot huisarts voor artsen in een driejarige vakopleiding.
Speciaal is ook het nieuwe opleidingsprogramma voor een master titel in
de epidemiologie dat in 2004 werd opgestart samen met andere faculteiten van de Universiteit Utrecht. Onderwijs voor onderzoekers van het
Julius Centrum vindt plaats door middel van deelname aan erkende
graduate schools zoals het Nihes (Netherlands Institute of Health
Science). Contracten met het management van het Nihes leidden tot een
intensievere samenwerking op het gebied van marketing en werving van
master studenten en een voorstel voor een gezamenlijke website voor de
Masteropleiding in Epidemiologie programma. Elk jaar groeit het aantal
onderwijsprogramma’s en dit jaar is een nieuw programma ontwikkeld
voor het medisch curriculum (Medical Humanities) dat zal worden
opgenomen in het curriculum vanaf september 2008.
Huisartsgeneeskunde is een belangrijke specialisatie in Nederland. De
medewerkers van Huisartsgeneeskunde in het Julius Centrum nemen
deel aan diverse onderwijsprogramma’s en geven cursussen op verschil-
216 Annual Report 2007
Nederlandse Samenvatting 217
lende niveau’s in de basis van het medisch curriculum (Bachelor,
Master). Daarnaast is er een vakopleiding en doorlopend medisch
onderwijs. Evenzo neemt het Julius Centrum actief deel aan de Bachelor,
Master, Post-Graduate/vakopleiding (waar van toepassing) en vervolgopleidingen op het gebied van Epidemiologie, Public Health, Medical
Humanities, Verplegingswetenschap en Voedingswetenschappen.
Patiëntenzorg
Diëtetiek
De groepen Voedingswetenschap en Diëtetiek vormen één unit.
Voedingswetenschappen richt zich op onderwijs en onderzoek, terwijl
de hoofdactiviteit van Diëtetiek bestaat uit het verschaffen van patiëntenzorg in het UMC Utrecht en het revalidatiecentrum “De Hoogstraat”.
Diëtetiek is landelijk koploper op het gebied van evidence-based diëtetiek en gestandaardiseerde processen voor diëtetiek professionals.
Het belangrijkste project van 2007 was de invoering van een elektronisch
patiëntendossier. Diëtetiek is het eerste onderdeel van het UMC Utrecht
dat werkt met het elektronisch patiëntendossier. De Diëtetiekgroep nam
deel aan een groot aantal externe (internationaal, nationaal en regionaal) en interne projecten, workshops, presentaties en cursussen in 2007.
Leidsche Rijn
Sinds januari 2004 heeft het Julius Centrum een netwerk voor academische patiëntenzorg, gesitueerd in het recent ontwikkelde Utrechtse
district “Leidsche Rijn”. In de komende paar jaar zal Leidsche Rijn uitbreiden naar een groter voorstedelijk gebied met ongeveer 80.000
inwoners. Zes gezondheidscentra zullen zorgdragen voor huisartsendienstverlening, fysiotherapie, geestelijke gezondheidszorg, moeder en
kind gezondheidszorg, apotheken en maatschappelijk werk. In het
onderliggende gezondheidszorgconcept voor Leidsche Rijn zijn deze
curatieve diensten nauw verbonden met preventieve, sociale en onderwijs activiteiten in het gebied.
In 2007 waren vijf gezondheidscentra operationeel: Parkwijk, dat
gezondheidsdienstverlener is voor 10.000 inwoners; Veldhuizen, met
218 Annual Report 2007
Nederlandse Samenvatting 219
9.000 geregistreerde patiënten; Terwijde, met 4.500 geregistreerde
patiënten dat sterk groeit; Vleuterweide, dat startte in 2006 in een zeer
concurrerende omgeving. Eind 2007 had Vleuterweide ongeveer 1.600
geregistreerde patiënten. Het vijfde gezondheidscentrum ’t Zand startte
in september 2007. Het Julius Centrum stuurt het management van de
gezondheidscentra aan. Het Leidsche Rijn netwerk biedt een uitstekende
mogelijkheid aan het Julius Centrum om haar ambities vorm te geven
op het gebied van het bieden van eerstelijns academische gezondheidszorg.
Unit Health Care Innovations
In februari 2007 heeft de Raad van Bestuur van het UMC Utrecht en het
Management Team van het Julius Centrum de Unit Health Care
Innovations opgericht. De missie van deze unit is het evalueren van
innovaties in organisaties, het ontwikkelen van instrumenten om aan
deze innovaties te werken en de distributie van kennis via cursussen,
congressen en lezingen. De unit richt zich op onderzoek naar 1.
Geïntegreerde zorg en ziektebeheer en 2. Hulpdiensten. In 2007 werkten
er een equivalent van 17 full time professionele medewerkers.
Operationele Ondersteuning
Management Support
De kernactiviteiten van het Julius Centrum, onderzoek, onderwijs en
patiëntenzorg, worden ondersteund door een aantal diensten. Het management wordt ondersteund door een centrale financiële afdeling, een
P&O afdeling en een ICT afdeling. In 2007 is de Julius Centrum website
compleet vernieuwd.
Subsidies
Het Julius Centrum is in hoge mate afhankelijk van externe fondsen
zoals die van de European Counsel en van Nederlandse onderzoeksfondsen zoals ZonMw.
Research Services
Research Services is beschikbaar voor interne (Julius Centrum) en
externe sponsors. Externe sponsors kunnen andere divisies van het
UMC Utrecht zijn, of farmaceutische bedrijven. De diensten bestaan uit
project management, coördinatie van clinical trials, site monitoring, site
management, endpoint adjudication management, melding van
medische fouten (adverse event reporting), clinical trial monitoring van
mono- en multi-center trials in Nederland en andere Europese landen,
een onderzoekskliniek en een Vascular Imaging Center.
In 2007 werd de naam CTSU (Clinical Trial Services Unit) geïntroduceerd om in de externe communicatie te verwijzen naar Research
Services.
220 Annual Report 2007
Nederlandse Samenvatting 221
Data Management
Data Management verzorgt de technische infrastructuur voor het verzamelen, verwerken en analyseren van epidemiologische gegevens. De
afdeling verleent deze diensten aan de onderzoekers van het Julius
Centrum, maar ook aan andere divisies van het UMC Utrecht, en aan
andere externe partijen.
Tot slot
222 Annual Report 2007
De overeenkomstige onderdelen van het jaarverslag gaan dieper in op de
bovengenoemde onderwerpen. Daarnaast geeft het jaarverslag informatie over de medewerkers van het Julius Centrum, de financiële stand van
zaken, lopende onderzoeksprojecten en niet te vergeten de publicaties
van 2007.
Nederlandse Samenvatting 223
Colophon
Editor: Manon Kluijtmans
Production: Hellen Braun
Concept: Marlice van der Werff / Gea Wolfslag
Design cover: Atelier Van Gog, Amsterdam
Design and lay out: Frank Boesveld, Multimedia, UMC Utrecht
Photography: Jacqueline Bosman, Multimedia, UMC Utrecht
Printing: ZuidamUithof drukkerijen, Utrecht
Circulation: 1000
University Medical Center Utrecht
Julius Center for Health Sciences and Primary Care
224 Annual Report 2007
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VACANCY
University Medical Center Utrecht
Julius Center for Health Sciences
and Primary Care
Address:
Heidelberglaan 100
3584 CX Utrecht
The Netherlands
Correspondence:
P.O. Box 85500
3508 GA Utrecht
The Netherlands
Phone +31 (0)88 75 681 81
Fax +31 (0)88 75 554 80
juliuscenter@umcutrecht.nl
www.umcutrecht.nl
www.juliuscenter.nl