Katalog kurser på forskarnivå HT15

Transcription

Katalog kurser på forskarnivå
HT15
# Människans biologi eller sjukdomslära * Allmänvetenskapliga kurser
1202 Human Cell Culture. Methods and Applications 20150921 20150925 (Engelska)
1383 Basic Course in Medical Statistics * 20151130 20151211 (Engelska)
1386 Philosophy of science and research ethics * 20151102 20151106 (Engelska)
1386 Medicinsk vetenskapsteori och forskningsetik * 20151005 20151009 (Svenska)
1391 Writing science and information literacy * 20151123 20151204 (Engelska)
1392 Vetenskapligt skrivande och informationskompetens * 20151026 20151106 (Svenska)
1472 Infections in the Tropics 20151014 20151231 (Engelska)
1496 Flow cytometry: from theory to application 20150921 20150925 (Engelska)
1507 Rörelseapparaten klinisk utvärdering av funktion och behandling 20151012 20151016
(Svenska)
1559 Experimental techniques in study of metabolic and endocrine disorders 20151130 20151204
(Engelska)
1577 Epidemiology I: Introduction to epidemiology 20150902 20150911 (Engelska)
1579 Biostatistics I: Introduction for epidemiologists * 20150916 20151006 (Engelska)
1594 Tumor immunology and immune therapy of cancer 20151116 20151120 (Engelska)
1595 Molecular Immunology 20151012 20151023 (Engelska)
1622 Epidemiology II. Design of epidemiological studies 20150831 20150909 (Engelska)
1626 Cytokines in inflammation 20151116 20151127 (Engelska)
1627 Clinical and experimental neuroimmunology 20151012 20151016 (Engelska)
1635 Basic course in Tumor Biology and Oncology 20150831 20150911 (Engelska)
1794 Study design in clinical research 20151116 20151204 (Engelska)
1814 Methods for Qualitative Content Analysis 20150929 20151125 (Engelska)
1873 Quality of life as an outcome measure in care sciences 20151116 20151127 (Engelska)
1974 Phenotyping of genetically engineered mice 20151207 20151211 (Engelska)
1999 Embryology I 20151012 20151016 (Engelska)
2000 Advanced seminars in Tumor Biology 20150901 20151222 (Engelska)
2001 What is life? The future of biology. 20150916 20160217 (Engelska)
2044 Pathology # 20151019 20151030 (Engelska)
2074 Current Topics in Infection Biology 20150902 20151216 (Engelska)
2132 Forskningsetik * 20150825 20150915 (Svenska)
2133 Vetenskapsteori * 20151006 20151201 (Svenska)
2135 Infectious Disease Epidemiology 20151012 20151016 (Engelska)
2144 To communicate science in different contexts * 20150916 20151001 (Engelska)
2154 Cardiovascular Epidemiology 20151019 20151023 (Engelska)
2166 Basic Tumor Histopathology 20150914 20150925 (Engelska)
2176 Cellular and molecular infection biology 20151026 20151106 (Engelska)
2186 How to make genetically modified mice for immunological research 20150907 20150911
(Engelska)
2188 Developmental biology for regenerative medicine 20150831 20150911 (Engelska)
2283 Live cell imaging 20151005 20151016 (Engelska)
2291 Clinical achievements of reproductive medicine 20150921 20150925 (Engelska)
2302 Basic immunology 20150915 20151029 (Engelska)
2348 Functional Fluorescence Microscopy Imaging (fFMI) in biomedical research 20151102 20151113
(Engelska)
2381 Survey of Molecular Endocrinology 20150928 20151009 (Engelska)
2407 Aktuell Omvårdnadsvetenskap teori och praxis 20151002 20151120 (Svenska)
2416 Causal Inference for Epidemiological Research 20151130 20151204 (Engelska)
2418 Methods in molecular biology and their applications in medical research 20150907 20150918
(Engelska)
2430 Principles of nucleic acid structure 20151116 20151204 (Engelska)
2433 Clinical Research in Lipid Metabolism 20151019 20151023 (Engelska)
2454 Public health intervention and implementation research 20151019 20151120 (Engelska)
2484 Thrombosis and Hemostasis, from mechanisms to therapies 20151102 20151106 (Engelska)
2498 Obesity basic science, clinical and epidemiological aspects 20151116 20151120 (Engelska)
2515 Cancer cell energy metabolism 20151102 20151106 (Engelska)
2518 Basics of Qualitative research 20150914 20150918 (Engelska)
2525 Cellular Reprogramming from basal mechanisms to medical applications 20150914 20150918
(Engelska)
2526 Neuropschopharmacology 20151123 20151201 (Engelska)
2536 The major global infectious diseases: tuberculosis and HIV 20151123 20151127 (Engelska)
2561 Writing Science and Information Literacy * 20150824 20151016 (Engelska)
2570 Introduction to R statistical analysis for biologists 20151109 20151113 (Engelska)
2583 Noncoding RNA and cancer 20151130 20151204 (Engelska)
2600 Neurogenetics 20150928 20151002 (Engelska)
2605 Brain development and Neurodevelopmental disorders 20150921 20150925 (Engelska)
2608 Mechanisms of Gene Regulation in Metabolism 20151105 20151111 (Engelska)
2609 Basic Course in Medical Statistics a distance course * 20150921 20151002 (Engelska)
2616 Frontiers in Cogntive Neuroscience 20150914 20150918 (Engelska)
2618 Write your research results and get them published * 20151012 20151023 (Engelska)
2624 Brain circuits 20150907 20150911 (Engelska)
2629 Neurodegenerative disorders I From molecule to treatment 20151005 20151009 (Engelska)
2630 Neurodegenerative disorders II cellular and molecular mechanisms 20151012 20151016
(Engelska)
2644 Human physiology an overview # 20150914 20150925 (Engelska)
2644 Människans fysiologi en översikt # 20150907 20150918 (Svenska)
2647 Surgical Techniques in Rat and Mouse 20150921 20150925 (Engelska)
2652 Mesenchymal stem cells biology and clinical potential. 20151012 20151016 (Engelska)
2654 Grounded Theory in Health Research 20151130 20151211 (Engelska)
2657 Introduktionskurs i R datahantering, analys och grafisk presentation 20151105 20151127
(Svenska)
2666 Metoder för statistisk analys: Från variansanalys till multilevel modeling * 20151012 20151030
(Svenska)
2668 Evidensbaserad verksamhet inom hörsel, öron, språk och tal 20150901 20151218 (Svenska)
2671 Tumor microenvironment 20151123 20151127 (Engelska)
2686 Introduction to teaching at KI * 20150902 20151007 (Engelska)
2688 Multidisciplinary perspectives on active ageing research 20150921 20151217 (Engelska)
2690 Basic Laboratory Safety * 20151109 20151116 (Engelska)
2690 Basic Laboratory Safety * 20150928 20151005 (Engelska)
2693 Measuring physical activity with focus on wearable monitors applications for clinical and
epidemiological studies 20151023 20151123 (Engelska)
2704 Metoder för systematisk litteraturöversikt 20150907 20151215 (Svenska)
2717 Hematopoiesis and hematopoietic stem cells in health and disease 20151026 20151030
(Engelska)
2721 Culture and Brain 20150901 20160215 (Engelska)
2743 Writing skills for science * 20150813 20150816 (Engelska)
2780 The Developing Brain 20150831 20150904 (Engelska)
2787 Present your research! * 20150831 20151110 (Engelska)
2787 Present your research! * 20150825 20151109 (Engelska)
2790 How to conduct systematic reviews and metaanalyses 20151019 20151104 (Engelska)
2794 Medical developmental biology 20150817 20150821 (Engelska)
2796 Introduction to Stata for epidemiologists 20150914 20150915 (Engelska)
2797 Biostatistics II: Logistic regression for epidemiologists * 20151207 20151216 (Engelska)
2827 Människans Fysiologi en översikt # 20151216 20160115 (Svenska)
2833 Introduction to Quantile Regression and Related Methods 20151102 20151106 (Engelska)
2839 Philosophy of science and research ethics, statistics and oral scientific communication * 20150921
20151023 (Engelska)
2841 The third dimension of nuclear functions 20151012 20151016 (Engelska)
2843 The cell cycle 20151116 20151120 (Engelska)
2844 Exploring entrepreneurial opportunities in research * 20151116 20151120 (Engelska)
2845 Cellbased heart regeneration 20150928 20151002 (Engelska)
2846 Integration of Neuroimaging and Cognition in Normal Aging and Dementia 20151109 20151113
(Engelska)
2849 Cancer and cancer stem cells 20151116 20151120 (Engelska)
2852 Initiating entrepreneurial thinking in connection to research 20150914 20151218 (Engelska)
2854 Translational lung cancer research 20151021 20151022 (Engelska)
2855 Digital photomicrography 20151019 20151023 (Engelska)
2856 Teaching and Learning in Higher Education: educational course for doctoral students a distance
course * 20150911 20151217 (Engelska)
2857 Orientation in qualitative research methods 20151105 20151119 (Engelska)
2858 Longitudinal data analysis classical and modern statistical methods 20151102 20151113
(Engelska)
2859 DNA damage and maintenance of genome integrity 20151012 20151016 (Engelska)
2860 Extracellular vesicles: a tool for diagnostics and therapy. 20151109 20151113 (Engelska)
2861 Biomedical Ecology The microbiota in health and disease 20151123 20151127 (Engelska)
2865 Regulatory RNAs in Development, Disease and Evolution 20151007 20151016 (Engelska)
Title : Human Cell Culture. Methods and Applications
Kursnummer : 1202
Antal högskolepoäng : 1.5
Datum : 20150921 20150925
Språk : Engelska
Nivå : Doctoral level
Kursansvarig institution : The institute of Environmental Medicine
Särskild behörighet : Kursens lärandemål : After the course, the students should be well acquianted with the theory and
practice of cell culture. Knowledge in basic and stateoftheart methods applied to cell cultures. To have
developed skills for bench work with cell cultures on an individual basis.
Kursens innehåll : Cell culture reflecting stem, transit amplifying, differentiated and terminally
differentiated tissue states; Monolayer and organotypic culture involving one or more cell types.
Applicability of cell cultures as alternatives to laboratory animal experiments. Mechanisms regulating cell
growth and viability, differentiation and apoptosis. Assessment of cell transformation to immortal and
malignant phenotypes. Isolation of specific cells, e.g., epithelial cells,characterisation of cultured cells.
Handling and sterile techniques, choice of materials and media for cell culture, e.g., serumdependent vs.
serumfree culture conditions. Cell cloning and gene transfer. Practical handling of cultures:
thawing/freezing, passage, expansion and longterm storage. Handling of normal and tumor tissue for
optimizing obtainment of cultures. Tissue engineering practices. Transcriptomics, proteomics and
informatics methods for biomedical research with cell lines. Discussion of participants own culture
experience and problems.
Arbetsformer : Lectures, laboratory work, ITuse and group discussions on pitfalls and possibilities with
cell cultures.
Examination : Literature studies and oral presentation of results for the course participants.
Obligatoriska moment : Presence at scheduled lectures and time allocated for oral examination of
allparticipants is compulatory. Opportunity to follow missed lectures is possible at repeat courses twice a
year (graduate courses 1202 and 1862). Based on documented participation in the lectures, the oral
examination can be arranged separately with the course organizer. Antal studenter : 10 15
Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's
doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority
given to earlier registration date)
Övrig information : Kursansvarig : Roland Grafstrom
Institutet för miljömedicin
Roland.Grafstrom@ki.se
Kontaktpersoner : Johanna Bergman
johanna.bergman@ki.se
Nobels väg 13
17177
Stockholm
Roland Grafstrom
Roland.Grafstrom@ki.se
Title : Basic Course in Medical Statistics
Kursnummer : 1383
Datum : 20151130 20151211
Språk : Engelska
Kursansvarig institution : Department of Learning, Informatics, Management and Ethics
Särskild behörighet : Kursens lärandemål : The course participants shall after the course be able to perform and interpret basic
descriptive statistics from frequency tables and graphical presentations, perform and interpret results from
basic statistical analysis and test (like ttest, chisquare test, nonparametric test and Regression analysis),
as well as have enhanced their ability to recognize, understand and critically view the statistics being
presented in articles within the medical field of research.
Kursens innehåll : The course is an introduction to basic statistical principles and how statistics play a part
in medical research. Concepts being treated are hypothesis, type I error, type II error, estimates,
measurement of dispersion, regression analysis, inference making and how to present the results.
Arbetsformer : This course is a so called TeamBased Learning (TBL)course. TBL is a special form of
learning that integrates individual assessment and group work with immediate feedback. Focus will be on
solving statistical problems in a group/team setting. This two weeks course consists of online preparation
through video lectures and exercises, and several TBL sessions (in class meeting). The in class meetings
will correspond to twothree full days each course week. The time in between meetings will be spent
reading the course material, and preparing for the assessment and group application exercises.
Examination : Individual and group assessments and active participation during the group application
exercises. Obligatoriska moment : In class attendance during TBL sessions are mandatory for passing grade. If the
student misses more than one TBL occasion, the doctoral student must take the course again.
Antal studenter : 40 50
Urval av studenter : Date for registration as a doctoral student (priority given to earlier registration date).
Please make sure that you have entered the correct registration date for doctoral education in your
personal profile.
Övrig information : This course is a TBLcourse. TBL, TeamBased Learning, is a special form of learning
that integrates individual work, group work and immediate feedback. Focus will be on solving statistical
problems in group/team setting. The course has the same content and length as the original course 1383.
The course will consist of 2 3 full days per week for two weeks.
Kursansvarig : Mesfin Tessma
Institutionen för lärande, informatik, management och etik
Mesfin.Tessma@ki.se
Kontaktpersoner : Margareta KrookBrandt
52487118
Margareta.KrookBrandt@ki.se
Title : Philosophy of science and research ethics
Kursnummer : 1386
Datum : 20151102 20151106
Språk : Engelska
Särskild behörighet : No
Kursens lärandemål : The objective of this course is for the doctoral student to gain a basic
understanding of the philosophy of science and insight into and understanding of key ethical theories,
principles and guidelines related to research and thereby be given the opportunity to reflect on the ethical
aspects of his/her own research. The objective is also to provide the doctoral student with an understanding
of what is good research practice, and also an understanding of the boundary between what is ethically
acceptable or unacceptable in terms of experimentation with human beings and animals. After completing
the course, the research student should: be able to give an account of the positions relative to the
philosophy of science and research ethical theories, principles and, to some extent current guidelines know
the most important terms within the philosophy of science and demonstrate knowledge of common problem
situations in research ethics and of the ethical tools used to manage conflicts concerning research ethics
be able to analyse ethical conflicts in research and see the connection between the philosophy of science
and research ethics be able to construct sustainable research ethical arguments for or against a specific
course of action have developed an ethical approach to research
Kursens innehåll : The course includes the following: Key ethical principles and theories of research
Fundamental values for empirical research, and standards of good scientific practice Experiments on
humans, including a review of informed consent, its ethical basis, and the pros and cons of practices for
informed consent Ethical tests and guidelines on how to conduct ethical research, such as the Helsinki
Declaration Ethics and the use of laboratory animals, including arguments for and against using animals for
research purposes, as well as the three Rs Handling of authorship in scientific writing Conflicts of interest
in research Key scientific terms and positions
Arbetsformer : Introducing lectures, group work and general discussions.
Examination : The doctoral students write a short informal essay on a scientific or research ethical theme
related to their own research. Obligatoriska moment : Attendance is mandatory for the group work and general discussions. If the
student is absent, he or she can compenste by handling in written answers concerning the cases that have
been discussed.
Urval av studenter : Selection is based on 1) the date of PhD registration (where prior registration dates
have priority) 2) curriculum relevant to the candidate's PhD project (as motivation).
Övrig information : Kursansvarig : Gert Helgesson
Gert.Helgesson@ki.se
Kontaktpersoner : Emma Karlsson
08524 83 777
emma.karlsson@ki.se
Kursnummer : 1386
Datum : 20150907 20150911
Språk : Engelska
been discussed.
Urval av studenter : Selection is based on 1) the date of PhD registration (where prior registration dates
have priority) 2) curriculum relevant to the candidate's PhD project (as motivation).
08524 83 777
emma.karlsson@ki.se
Kursnummer : 1386
Datum : 20151130 20151204
Språk : Engelska
been discussed.
Urval av studenter : Selection is based on 1) date of PhD registration (where prior registration dates have
priority) 2) the curriculum relevant to the candidate's PhD project (as motivation).
08524 83 777
emma.karlsson@ki.se
Title : Medicinsk vetenskapsteori och forskningsetik
Kursnummer : 1386
Datum : 20151005 20151009
Språk : Svenska
Nivå : Forskarnivå
Särskild behörighet : Nej
Kursens lärandemål : Målet med kursen är att den forskarstuderande ska få en grundläggande
vetenskapsteorisk förståelse och inblick i och förståelse av centrala forskningsetiska teorier, principer och
riktlinjer och därmed få möjlighet att reflektera över etiska aspekter av den egna forskningen. Målet är
också att den forskarstuderande ska få en förståelse av vad som är god forskningssed, samt var gränsen
går för vad som är etiskt oacceptabelt både vad gäller försök med människor och med djur. Den
forskarstuderande ska efter att ha gått kursen: kunna redogöra för vetenskapsteoretiska positioner samt
forskningsetiska teorier, principer och, i viss mån, riktlinjer känna till centrala vetenskapsteoretiska termer
samt vanliga forskningsetiska problemsituationer och de etiska verktygen för att hantera forskningsetiska
konflikter kunna analysera forskningsetiska konflikter och se kopplingen mellan vetenskapsteori och
forskningsetik kunna ge hållbara forskningsetiska argument för eller mot ett förfarande ha utvecklat ett
forskningsetiskt förhållningssätt Kursens innehåll : Kursen innehåller följande moment: Centrala forskningsetiska principer och teorier
Grundläggande värderingar för empirisk forskning samt normer för god vetenskaplig sed Försök med
människor, inklusive en genomgång av informerat samtycke, dess etiska grund och för och nackdelar med
rutiner för informerat samtycke Etikprövningar och forskningsetiska riktlinjer, såsom
Helsingforsdeklarationen Försöksdjursetik, innefattande argument för och emot att använda djur för
forskningsändamål, samt de tre R:en Hantering av vetenskapligt författarskap Intressekonflikter i
forskningen Centrala vetenskapliga termer och positioner Arbetsformer : Introducerande föreläsningar, grupparbeten och plenumdiskussioner.
Examination : Deltagarna skriver en egen vetenskapsteoretisk eller forskningsetisk reflektion över sitt
eget forskningsprojekt.
Obligatoriska moment : Vid frånvaro krävs särskilt utförliga svar på de fall som diskuterats.
Gruppdiskussionerna och plenumdiskussionerna är obligatoriska.
Urval av studenter : Urvalet baseras på 1) datum för doktorandregistrering (där tidigare
registreringsdatum har förtur) 2) kursplanens relevans för den sökandes doktorandprojekt (enligt
motivering). Övrig information : Kursansvarig : Gert Helgesson
08524 83 777
emma.karlsson@ki.se
Title : Writing science and information literacy
Kursnummer : 1391
Datum : 20151123 20151204
Språk : Engelska
Kursansvarig institution : Karolinska Institutet University Library
Särskild behörighet : Kursens lärandemål : After the course, you should be able to demonstrate: understanding of how to
write an original scientific article and submit it for publication the ability to write other types of texts
required for a scientific career the ability to give, take and make use of constructive criticism the ability to
search and manage the medical sciences literature in a structured way the ability to use resources which
facilitate choosing a journal to publish your research in the ability to describe aspects of postpublication
evaluation and processing of the medical sciences literature Kursens innehåll : Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and
tables, Revising structure and style, Ethical issues in writing, Publication process, Principles of medical
information retrieval, Databases, Reference management, Choosing a journal and Evaluating published
science
Arbetsformer : Individual writing and rewriting, lectures, working in pairs and groups, webbased
teaching, demonstrations, computer exercises and individual study. NOTE THAT THIS IS THE KISOLNA
CAMPUS VERSION OF THE COURSE. THERE IS ALSO AN ONLINE VERSION (COURSE CODE 2561)
INTENDED PRIMARILY FOR DOCTORAL STUDENTS HAVING DIFFICULTIES TO ATTEND THE KISOLNA
CAMPUS COURSES.
Examination : Writing a grant application (including references) with popular science summary and
rewriting based on peer and teacher feedback. There are also three assignments in which participants
demonstrate development of their information literacy.
Obligatoriska moment : The course writing assignment is obligatory and has to be submitted about 10
days BEFORE course start. All scheduled teaching is compulsory (except where clearly stated otherwise).
Absence can usually be compensated for by reading and individual work after consultation with course
leaders. Antal studenter : 30 34
Övrig information : Kursansvarig : David Herron
Karolinska Institutet Universitetsbibliotek
08524 841 13
David.Herron@ki.se
Berzelius 7B
17177
Stockholm
Kontaktpersoner :
Title : Vetenskapligt skrivande och informationskompetens
Kursnummer : 1392
Datum : 20151026 20151106
Språk : Svenska
Särskild behörighet : Kursens lärandemål : Efter kursen ska du kunna visa: förståelse för hur man skriver en vetenskaplig
artikel och skickar in den för publicering förmåga att skriva andra typer av texter som en del i det
vetenskapliga arbetet förmåga att ge, ta emot och använda konstruktiv kritik förmåga att söka och
hantera den vetenskapliga litteraturen på ett strukturerat sätt förmåga att använda olika resurser som
stöd vid valet av tidskrift att publicera sig i förmåga att beskriva aspekter av hur man kan utvärdera
publicerad vetenskap Kursens innehåll : Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and
tables, Revising structure and style, Ethical issues in writing, Publication process, Principer för medicinsk
databassökning, Databaser, Referenshantering, Val av tidskrift och Evaluera publicerat vetenskap.
Arbetsformer : Individuella skrivuppgifter och revision, föreläsningar, par och grupparbeten, webbaserat
lärande, demonstrationer, datorövningar och individuella studier. OBS. KURSDELEN SOM BEHANDLAR
VETENSKAPLIGT SKRIVANDE HÅLLS PÅ ENGELSKA OBS. DET FINNS OCKSÅ EN ONLINE VERSION AV
KURSEN PÅ ENGELSKA (KURSKOD 2561) AVSEDD PRIMÄRT FÖR DOKTORANDER MED SVÅRIGHETER ATT
VARA MED PÅ KI CAMPUS SOLNA KURSERNA. Examination : Skrivande av en anslagsansökan (på engelska) med populärvetenskaplig sammanfattning
(på svenska) samt bearbetning (med referenser) baserat på "peer" och lärarkommentarer. Det finns också
tre uppgifter som demonstrerar utvecklingen av deltagarnas informationskompetens. Obligatoriska moment : Skrivuppgiften är obligatorisk och måste inlämnas cirka 10 dagar FÖRE kursens
början. Samtliga schemalagt undervisningpass är obligatoriska. Frånvaro kan oftast kompenseras efter
samtal med kursledarna. Antal studenter : 30 34
Urval av studenter : Urvalet baseras på 1) kursplanens relevans för den sökandes doktorandprojekt
(enligt motivering), 2) datum för doktorandregistrering (där tidigare registreringsdatum har förtur)
Övrig information : Kursansvarig : David Herron
08524 841 13
David.Herron@ki.se
Berzelius 7B
17177
Stockholm
Kontaktpersoner :
Title : Infections in the Tropics
Kursnummer : 1472
Datum : 20151014 20151231
Språk : Engelska
Kursansvarig institution : Department of Medicine, Solna
Särskild behörighet : Kursens lärandemål : To understand the conditions under which the major infectious diseases in the
tropics arise and how they are prevented/treated locally. To understand the conditions for biomedical
research in a low or middle income country from within and to be able to account for some of the current
local research issues. To be able to discuss these issues with health care professionals and researchers in a
satisfactory way.
Kursens innehåll : Field studies under local staff in low or middle income country and Swedish supervision
at the primary,secondary and tertiary health care level. Joint seminars (mutual presentations of research projects) at local research institute. Students will present their findings of elective projects at the end of the
course. Arbetsformer : Bedside and benchside teachings at hospitals and polyclinics/health care centers.
Seminars. Elective works with oral and written presentations. Field studies will take place in in a low or
middle income country. Examination : Formative assessment of ability to discuss the specific issues encountered with health care
professionals and researchers. Presentation of elective projects to Swedish faculty. Every student will be
examined individually. Obligatoriska moment : Field studies, joint seminars at local research institute, presentation of elective
projects. Absence cannot be compensated for.
Övrig information : The course starts with five twohour evening lectures covering the major tropical
infections such as malaria, helminth infections, tuberculosis/leprosy and leishmania trypanosomiasis. These
will take place Wednesday evenings between 17.3019.00 hrs, starting Oct 14, 2015 at the Dept of
Infectious Diseases, Karolinska Hospital,Solna. One additional session will be devoted to designing elective
projects to be conducted during the field session in Ethiopia. Field session in Ethiopia is
planned for between Nov 28 Dec 21, 2015. Final course week will be between Dec 28 Dec
31, 2015 when elective projects will be reported/discussed and a written quiz issued. A fee
of US$1500 will be required to contribute towards full board accommodation and local transport costs. An
official receipt of the paid sum will be issued for putative reimbursement by the home Department.
International travel and tuition/bench fees will be covered by the course grant. Kursansvarig : Sven Britton
Institutionen för medicin, Solna
0851771967
Sven.Britton@ki.se
Oxtogsgränd 1
11157
Stockholm
Kontaktpersoner : Anne Rasikari
08517 718 61
Anne.Rasikari@ki.se
B3:03
Sven Britton
0851771967
Sven.Britton@ki.se
Oxtogsgränd 1
11157
Stockholm
Title : Flow cytometry: from theory to application
Kursnummer : 1496
Datum : 20150921 20150925
Språk : Engelska
Särskild behörighet : Kursens lärandemål : Through this oneweek course, the participants will acquire the knowledge of flow
cytometry principles. They will know flow cytometric sample preparation and analysis, protocol setup, as
well as data interpretation.
Kursens innehåll : The course covers basic knowledge and main applications of flow cytometry, and
contains both lectures and laboratory/group work. Experts in different fields of flow cytometric application
are invited to give the lectures. The participants will be able to learn: a) Principles of flow cytometry:
working mechanisms of flow cytometer; molecular and cellular probes for flow cytometry; quality control;
and safty procedures and intrument maintainance. b) Basic skills: flow cytometric protocol design; sample
handling and storage; data processing and analysis, and data presentation. c) Major applications of flow
cytometry in biomedical research: leukocyte phenotyping, endothelial cell analysis, stem cell analysis,
apotosis, platelet measurement, cell function analysis (including membrane potential, oxidative metabolism,
intracellular calcium mobilization, pH, and intracellular organelles), as well as nucleic acid analysis.
Arbetsformer : The course includes 28 hr lectures and 12 hr handson lab work.
Examination : The exam will consist two parts: a 30min written test on flow cytometric principles; and a
60 min handson lab work examining flow cytometric lab skills
Obligatoriska moment : The participants must attend handson lab sections during two afternoons. The
students who have missed these sections can book extra lab section time within 4 weeks to compensate the
absence.
Urval av studenter : The course used to receive far more applications than the maximal course slots of
32. Selection of the participants is thus needed and made according to: 1) How relevant is flow cytometry
to the thesis project? 2) How urgent is the flow cytometry training for her/his project work? 3) Has the
student applied for the course before?
Övrig information : The course will be held during week 39 (Sept 2125, 2015; 9:0016:30). Lecture hall
booked: Block Salen, T4:00 at Karolinska University HospitalSolna. Lectures will be given by 1415
lecturers, usaually half of them from institutions outside KI, with one or two from abroad. All the lecturers
are wellestablished flow cytometrists on their lecture subjects. The course has been given 12 times/year
at KI for 14 years. It has been highly appreciated by the participants through the years, with a median
general satisfaction score never below 8 (out of 9; referred to paperbased course evaluation between
20012013), and highly remarked with the websurvey (2014).
Kursansvarig : Nailin Li
0851773996
Nailin.Li@ki.se
Clinical Pharmacology Unit
Karolinska University HospitalSolna
17176
Stockholm
Kontaktpersoner : Nailin Li
0851773996
Nailin.Li@ki.se
17176
Stockholm
Title : Rörelseapparaten klinisk utvärdering av funktion och
behandling
Kursnummer : 1507
Datum : 20151012 20151016
Språk : Svenska
Kursansvarig institution : Department of Molecular Medicine and Surgery
Särskild behörighet : Kursens lärandemål : Kunskaper: Kunskaper om metoder, försöksplanering och statistisk bearbetning av
material inom kliniska forskningsprojekt som berör rörelseorganens sjukdomar och skador. Färdighet:
Kunna framställa och värdera en forskningsplan för ett projekt inom rörelseorganens sjukdomar.
Förhållningssätt: Ha lärt sig ett vetenskapligt och kritiskt förhållningssätt till den vetenskapliga litteraturen
inom området för rörelseorganens sjukdomar och skador.
Kursens innehåll : Klinisk utvärdering av funktion och behandling inom rörelseorganens sjukdomar och
skador.
Arbetsformer : Katedrala föreläsningar, gruppövningar kring ett tänkt forskningsprojekt.
Examination : Kursdeltagarna redovisar de forskningsprojekt som de arbetat med under kursen och
projektet diskuteras med övriga kursdeltagare och en lärarpanel bestående av kursledningen och speciellt
inbjudna experter. Under denna diskussion testas kursdeltagarnas kunskaper, färdigheter,
värderingsförmågor och förhållningssätt utifrån lärandemålen
Obligatoriska moment : Antal studenter : 5 20
Övrig information : Kunskaper: Kunskaper om metoder, försöksplanering och statistisk bearbetning av
material inom kliniska forskningsprojekt som berör rörelseorganens sjukdomar och skador. Färdighet:
Kunna framställa och värdera en forskningsplan för ett projekt inom rörelseorganens sjukdomar.
Förhållningssätt: Ha lärt sig ett vetenskapligt och kritiskt förhållningssätt till den vetenskapliga litteraturen
inom området för rörelseorganens sjukdomar och skador. Klinisk utvärdering av funktion och behandling
inom rörelseorganens sjukdomar och skador. Katedrala föreläsningar, gruppövningar kring ett tänkt
forskningsprojekt. Kursdeltagarna redovisar de forskningsprojekt som de arbetat med under kursen och
projektet diskuteras med övriga kursdeltagare och en lärarpanel bestående av kursledningen och speciellt
inbjudna experter. Under denna diskussion testas kursdeltagarnas kunskaper, färdigheter,
värderingsförmågor och förhållningssätt utifrån lärandemålen Kursansvarig : Lars Weidenhielm
Institutionen för molekylär medicin och kirurgi
Lars.Weidenhielm@ki.se
Kontaktpersoner :
Title : Experimental techniques in study of metabolic and
endocrine disorders
Kursnummer : 1559
Datum : 20151130 20151204
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course the students will be able i) to measure glucose transport in
isolated rodent skeletal muscle; ii) to measure lipolysis in isolated adipocytes; iii) to dissect out mouse
pancreatic islets and measure the insulin release; iv) to judge and analyze obtained data. The students will
be able to describe the possibilities and limitations of the above techniques. Kursens innehåll : The aim of this course is to provide methodology to solve preclinical problems in
metabolic and endocrine research. The course is laboratory based, aiming to give all participants hands on
experience with isolation of pancreatic islets, skeletal muscle and adipose tissue. Theoretical and practical
considerations will be presented and discussed.
Arbetsformer : The course meets for five days full time, including three full day laboratory practical
sessions. The first day will consist of several lectures to give a background to the metabolic questions which
will be addressed in the practical part of the course. Our aim is to provide the student with a hands on
experience of each technique covered. In order to achieve this, for the laboratory work the course
participants will be subdivided into smaller groups.
Examination : The laboratory notebook examination from each student, a short oral presentation of the
project work and a short summary of the project work by each group.
Obligatoriska moment : All three laboratory tasks are compulsory; as an exception, a written task could
be given to a participant to compensate absence.
Övrig information : Kursansvarig : Alexander Chibalin
0852487512
Alexander.Chibalin@ki.se
Kontaktpersoner :
Title : Epidemiology I: Introduction to epidemiology
Kursnummer : 1577
Datum : 20150902 20150911
Språk : Engelska
Kursansvarig institution : Department of Medical Epidemiology and Biostatistics
Särskild behörighet : Kursens lärandemål : After successfully completing this course students are expected to be able to: give
examples of the contribution of epidemiology to science and discuss the importance of epidemiology as a
research discipline. estimate and in a general way interpret measures of disease occurrence and measures
of association, and describe how a specific measure is governed by the study design. explain strengths and
weaknesses of common epidemiological study designs. identify and explain possible sources of bias in
epidemiological studies. describe theoretical models for causation and discuss the principles of causal
mechanisms. apply knowledge of epidemiological concepts when critically reviewing scientific literature. Learning outcomes are classified according to Bloom´s taxonomy: knowledge, comprehension, application,
analysis, synthesis, and evaluation.
Kursens innehåll : The course gives an introduction to epidemiological theory and practice. It comprises
basic principles regarding design, interpretation, and analysis of epidemiological studies. It introduces the
concept of causation, concepts related to measures of disease occurrence and measures of association,
common designs for epidemiological studies (with main focus on cohort studies), and the role of bias.
Arbetsformer : The course focuses on active learning, i.e. putting knowledge into practice and critically
reflecting upon the knowledge, rather than memorising facts. Different strategies for teaching and learning
will be used, such as lectures, group discussions and various forms of group exercises on selected topics.
Examination : To pass the course, the student has to show that the learning outcomes have been
achieved. Assessments methods used are group assignments along with written and oral individual tasks.
The examination is viewed as contributing to the development of knowledge, rather than as a test of
knowledge. Students who do not obtain a passing grade in the first examination will be offered a second
chance to resubmit the examination within two months of the final day of the course. Students who do not
obtain a passing grade at the first two examinations will be given top priority for admission the next time
the course is offered. Obligatoriska moment : The examination tasks are compulsory. Antal studenter : 12 25
Urval av studenter : Selection will be based on 1) the relevance of the course for the applicant's project
(according to written motivation), 2) date for registration as a doctoral student (priority given to earlier
registration date). Submit a completed application form and give all information requested, including a
short description of current research, motivation for attending and an account of previous courses.
Övrig information : Course dates are: September 2, 4, 7, 9 and 11. The course is extended over 2 weeks
(but still 5 full course days) in order to promote reflection and reinforce learning
Kursansvarig : Fang Fang
Institutionen för medicinsk epidemiologi och biostatistik
Fang.Fang@ki.se
Kontaktpersoner : Gunilla Nilsson Roos
08524 822 93
gunilla.nilsson.roos@ki.se
Title : Biostatistics I: Introduction for epidemiologists
Kursnummer : 1579
Datum : 20150916 20151006
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After successfully completing this course students should be able to: define the
concept of probability, laws of probability, and make simple probability calculations. (S2) suggest a
statistical distribution to describe a naturally occurring phenomonen and evaluate the appropriateness of
the distribution given real data. (S3) present appropriate descriptive statistics for an epidemiological
study. (S2) explain the difference between hypothesis testing and interval estimation and the relation
between pvalues and confidence intervals. (S3) suggest an appropriate statistical test for a comparison of
two groups, perform the hypothesis test using standard statistical software, and interpret the results. (S3)
estimate and interpret three alternative measures of association between binary exposures and binary
outcomes and discuss the relative merits of each measure for a given research question. (S3) explain the
concept of confounding in epidemiological studies and demonstrate how to control/adjust for confounding
using stratified analysis. (S2) explain the basis of the linear regression model, fit a linear regression model
using standard statistical software, assess the fit of the model, and interpret the results. (S2) Learning
outcomes are classified according to Bigg's structure of the observed learning outcome (SOLO) taxonomy:
(S1) unistructural, (S2) multistructural, (S3) relational, and (S4) extended abstract.
Kursens innehåll : The course introduces classical statistical concepts and methods with emphasis on
methods used in epidemiology and public health. Topics covered include: the importance of statistical
thinking; types of data (nominal, binary, discrete and continuous variables); data summary measures;
contingency tables; graphical representations; notions of probability; probability models (distributions);
principles of statistical inference; parameter estimation (mean, proportion (prevalence), incidence and
ratios); concepts of confidence intervals and hypothesis tests; and a general introduction to correlation and
linear regression models. Arbetsformer : Lectures, exercises focusing on analysis of real data using statistical software, exercises
not requiring statistical software, group discussions, literature review.
Examination : The course grade is based mainly on a written examination, but group tasks and individual
written assignments are also used. The course is divided into two parts, and each part will be examined
separately. To pass the course, a student must pass both parts. Students who fail will be offered a re
examination within 2 months of the final day of the course. Students who fail the reexam will be given top
priority for admission the next time the course is offered. If the course is not offered during the following
two academic terms then another reexamination will be scheduled within 12 months of the final day of the
course. Obligatoriska moment : Antal studenter : 12 25
Övrig information : The course is extended over time in order to promote reflection and reinforce
learning. The course will be held the dates: September 16, 17, 18, 21, 22 and examination September 24
(week 1), and September 28, 29, 30 and October 1, 2 and examination October 6 (week 2). We strongly
recommend prior knowledge in Stata software. Kursansvarig : Yudi Pawitan
Yudi.Pawitan@ki.se
08524 822 93
Title : Tumor immunology and immune therapy of cancer
Kursnummer : 1594
Datum : 20151116 20151120
Språk : Engelska
Kursansvarig institution : Department of OncologyPathology
Särskild behörighet : Kursens lärandemål : After the course is completed the students will be able to (1) explain important
aspects of tumor immunology, (2) indicate advantages and disadvantages of different immune therapy
strategies, (3) explain mechanisms of immune escape, 4) hypothesize how different immunebased
regimens may affect clinical outcome in patients with cancer. Kursens innehåll : This course covers basic and applied immunology and a current review of experimental
research and clinical application of tumor immunology. Both preclinical and clinical aspects of cancer
vaccination, adoptive cell therapy, and antibody therapy will be discussed. Development of novel therapies
through modification of immune cell subsets will be presented. Features of the tumor microenvironment,
cancerassociated inflammation, immune surveillance and escape, and immunosuppression will also be
discussed. Planning, performing, and monitoring of clinical trials are included in the course as well. One to
two days are dedicated to lectures by invited international experts from the field.
Arbetsformer : Lectures, seminars, group discussions and casestudies. Examination : Oral group presentation and individual assignment based on casestudies. Every student
will be individually assessed.
Övrig information : Full day lectures/assignments from Monday to Friday at the Lecture hall of the Cancer
Center Karolinska (R8:00). There will at least 4 invited international speakers.
Kursansvarig : Rolf Kiessling
Institutionen för onkologipatologi
0851776857
Rolf.Kiessling@ki.se
Kontaktpersoner : Andreas Lundqvist
Andreas.Lundqvist@ki.se
Jeroen Melief
jeroen.melief@ki.se
Kristina Witt
kristina.witt@ki.se
Title : Molecular Immunology
Kursnummer : 1595
Datum : 20151012 20151023
Språk : Engelska
Kursansvarig institution : Department of Microbiology, Tumor and Cell Biologi
Särskild behörighet : Kursens lärandemål : After the course, the student should be able to relate their own research project to
the cuttingedge developments in other areas of immunology research. Furthermore, they should have
gained increased experience in preparing and presenting novel information about an immunological problem
or a specific technique to their fellow students.
Kursens innehåll : The course is given during 2 weeks. Invited national and international lecturers give
their views on selected problems, or techniques, in immunology. The seminars take off from basic facts, but
the speakers are encouraged to move on to current problems, and to focus on both scientific and
methodological aspects. To merit 3 full ECTS points for the course, students will be asked, in a group
project work, to study an immunological method or problem deeply at the theoretical level and lecture
about this method to the fellow students. At the end of the course, a written and an oral presentation is
expected from all students.
Arbetsformer : Lectures, group work, oral and written presentations
Examination : Evaluation of oral and written presentation of project work. Specific contibution of each
group participant will be investigated and evaluated. A short written exam based on the content of the
course.
Obligatoriska moment : Oral presentations at the end of the course. Written project work and written
test. If a student misses the presentation, a special presentation with the course leader will be arranged.
Övrig information : The course will be held on weekdays with most lectures from 9.00 to 12.00. All
lectures will be held at MTC Nobelsväg 16 on the Solna Campus. The course will also include invited
lecturers from universities outside Sweden who are experts in their field
Kursansvarig : Jonathan Coquet
Institutionen för mikrobiologi, tumör och cellbiologi
jonathan.coquet@ki.se
Kontaktpersoner : Robert Wallin
Institutionen för medicin, Huddinge
0858589197
Robert.Wallin@ki.se
Benedict Chambers
Benedict.Chambers@ki.se
Title : Epidemiology II. Design of epidemiological studies
Kursnummer : 1622
Datum : 20150831 20150909
Språk : Engelska
Särskild behörighet : Knowledge in epidemiology equivalent to "Epidemiology I: Introduction to
epidemiology" or corresponding courses.
Kursens lärandemål : After successfully completing this course you as a student are expected to be able
to: in a selfdirected manner, formulate the principles of different types of common epidemiological study
designs. mainly independently, explain how a specific measure of disease occurrence and measure of
association is governed by the study design. in a selfdirected manner, explain and discuss
epidemiological concepts, including accuracy, in the context of different epidemiological study designs.
draw conclusions from epidemiological scientific papers and to review and criticize these regarding study
design, results and accuracy. Learning outcomes are classified according to Bloom's taxonomy:
knowledge, comprehension, application, analysis, synthesis, and evaluation. Kursens innehåll : The course focus on issues related to study design (primarily casecontrol
methodology), study base, study efficiency, matching in epidemiological studies, induction time,
interpretation of epidemiologic evidence. Arbetsformer : Lectures, group discussions and various forms of group exercises on selected topics, will
be used. The course focuses on active learning, i.e. putting knowledge into practice and critically reflecting
upon the knowledge, rather than memorising facts. Examination : To pass the course, the student has to show that the learning outcomes have been
achieved. Assessments methods used are group tasks along with written and oral individual tasks.The
examination is viewed as a contributing to the development of knowledge, rather than as a test of
knowledge. Students who do not obtain a passing grade in the first examination will be offered a second
examination within two months of the final day of the course. Students who do not obtain a passing grade
at the first two examinations will be given top priority for admission the next time the course is offered. Obligatoriska moment : Only the examination tasks are compulsory.
Urval av studenter : Prerequisite knowledge Epidemiology I: Introduction to epidemiology or
corresponding. We also strongly recommend Biostatistics I: Introduction for epidemiologists or equivalent.
Selection will be based on 1) the relevance of the course for their research 2) the stated motivation for
attending the course. Please submit a completed application form and give all information requested incl. a
short description of current research, motivation for attending and an account of previous courses taken.
learning. Course dates are: August 31, September 2, 4, 7 and 9.
Kursansvarig : Karin Leander
0852487498
Karin.Leander@ki.se
Box 210 (Nobels väg 13), KI
171 77
Stockholm
Kontaktpersoner : Ida Kettley Cronfalk
ida.kettley.cronfalk@ki.se
Title : Cytokines in inflammation
Kursnummer : 1626
Datum : 20151116 20151127
Språk : Engelska
Särskild behörighet : None
Kursens lärandemål : Objectives At the end of the course the participant should be able to: select
adequate experimental methods to analyze cytokines based on specific scientific questions understand
the relevance of cytokines in the context of their research project compare and contrast the function of
cytokines in different organs and different diseases explain how a disease can be treated with drugs
targeting cytokines hypothesize future treatment of a disease, where the modification of a cytokine
pattern is the target
Kursens innehåll : Learning how to measure cytokine responses in different ways and understanding the
function of cytokines in immunological networks.
Arbetsformer : The course is partly theoretical, partly practical, where lectures and laboratory
demonstrations are integrated. Time is also allocated for discussing of lab results and lectures, and for
group assignment.
Examination : To pass the course the participant has to: actively participate in the discussions during
the course present a seminar where different aspects of a cytokine will be discussed, i.e. disease involved
and overall biological effects, and describe and discuss methods to detect it within the methods presented
during the course. take a written exam during the last day of the course. This exam will cover the
course's theoretical and practical content.
Obligatoriska moment : Practical sessions are compulsory, unless stated not. Absence from several
practical sessions cannot be compensated for, but absence from one theoretical session can be
compensated for in subsequent sessions.
Urval av studenter : Priority will be given to 1) PhD students working in the field of immunology 2) early
stage students with at least basic knowledge in immunology (year 1 2), and 3) expressed written
motivation to attend the course.
Övrig information : The aim of the course is to provide an increased understanding of the function of
cytokines in the context of healthy immune system and in different disease contexts. Note: This is not a
basic course of immunology. Location: KI campus Solna. Time: 09.0016.00 all days. Course content
includes lectures from invited experts and KI experts, and local staff are also involved in practical work.
Kursansvarig : Andre Ortlieb
Institutionen för klinisk neurovetenskap
Andre.Ortlieb@ki.se
Kontaktpersoner : Heidi Wähämaa
Heidi.Wahamaa@ki.se
Title : Clinical and experimental neuroimmunology
Kursnummer : 1627
Datum : 20151012 20151016
Språk : Engelska
Kursansvarig institution : Department of Clinical Neuroscience
Särskild behörighet : Kursens lärandemål : After this course the students should be able to: (i) describe the basic clinical
characteristics of the major neuroinflammatory diseases; (ii) design experiments using animal models for
neuroinflammatory diseases in rats and mice, compare models and discuss their advantages and
limitations, (iii) evaluate and interpret new findings and recent scientific papers in the field and (iv)
speculate on molecular mechanisms underlying neuroinflammatory disease and hypothesize how knowledge
on these mechanisms can enable therapy and prevention.
Kursens innehåll : The course includes the overview of clinical symptoms, signs, pathology, treatments
and diagnostic criteria for the most important neuroimmunological conditions including Multiple Sclerosis,
Myasthenia Gravis, GuillainBarré Syndrome, Alzheimer¿s disease as well as infections, trauma, tumors and
pain. Also included is an overview of experimental models of neuroimmunological diseases, with an
emphasis on techniques for genetic analysis (intercrosses, congenics, transgenics etc). Key molecular
concepts in neuroinflammation are covered such as immune mechanisms of disease as well as tissue
degeneration/regeneration. Different techniques used to study neuroinflammation are discussed such as
imaging and flow cytometry. Arbetsformer : The course combines: (i) traditional lectures given by experts in the field, consisting of a
mixture of both clinicians as well as basic researchers covering diseases, technological aspects or basic
processes in neuroimmunology; (ii) an individual assignment followed by an interactive
presentation/discussion on the last day. The assignment will consist of a presentation of a highimpact
scientific paper relevant to the student¿s own research topic and that is of importance for the
neuroimmunology field. Examination : Examination will be based on the presentation of the own individual assignment and the
subsequent discussion during the last day of the course (please see "Teaching and learning activities") and
the feedback given to other students on their assignments. In their presentation, students should be able to
comment on their article of choice in the context of the items described above under "learning outcomes".
Guidelines for the preparation of the assignment will be sent out to the students two weeks before the start
of the course. Obligatoriska moment : All lectures and individual presentations are compulsory. Compensation for
absence can be discussed with the course directors.
Övrig information : This course is part of both the Neuroscience and the Allergy, Immunology and
Inflammation Doctoral Programmes Time: MondayFriday, 9:0017:00; Location: Center for Molecular
Medicine (CMM), Karolinska University Hospital, Solna, building L8, lecture hall/seminar room; Speakers
last year included Prof Jan Hillert (MS genetics), Docent Adnane Achour (MHCTCR interaction), Prof Tomas
Olsson (MS), Dr Rayomand Press (GBS), Prof Fredrik Piehl (neuroprotection), Prof. Dr. Frauke Zipp
(University of Mainz; CNSimmune cell interaction); Prof. Burkhardt Becher (University of Zurich; Tumors in
the CNS)
Kursansvarig : Xingmei Zhang
Xingmei.Zhang@ki.se
CMM
Stockholm
Kontaktpersoner : Andre Ortlieb
Andre.Ortlieb@ki.se
Pernilla Strid
Pernilla.Strid@ki.se
Maja Jagodic
+46851776258
Maja.Jagodic@ki.se
Neuroimmunology Unit, CMM, L8:04
17176
Stockholm
Title : Basic course in Tumor Biology and Oncology
Kursnummer : 1635
Datum : 20150831 20150911
Språk : Engelska
Särskild behörighet : Kursens lärandemål : This is a basic course for all PhDstudents in the field. After the course the students
will have an understanding of the cancer problem, the modern view what cancer is, from a clinical and basic
science view. You will get the basic foundations of cancer biology as well as aquire some ability to discuss
and understand advanced problems in cancer biology. You will have an idea which are the current most
important problems to solve in cancer, to improve diagnosis, prevention, treatment and quality of life. The
over all aim of the course is to form a bridge between preclinical and clinical aspects of tumor biology and
oncology for PhD students and to provide the students an understanding of all aspects of the cancer
problem. This course is a basic introduction to modern cancer research and is recommended to all PhD
students within basic and clinical cancer research. Kursens innehåll : The course will describe the causes as well as the consequences of the transformation
of a normal cell into its malignant counterpart, in order to create an understanding of cancer from
molecule to patient, eventually also discussing the management and treatment of malignant diseasesThe
topics of the course include genetics, the cell cycle, apoptosis, immunology, diagnostics and treatment, all
topics presented from the cancer perspective. There will be focus on a few malignant diseases, described in
more detail serving as models for basic concepts of Tumor Biology and Oncology, including molecular
genetics, curative treatment and palliative care, psychosocial aspects of cancer, ethics and epidemiology. All seminars and demonstrations are compulsory, also some lectures, as well as the written examination.
Single missed occasions can be compensated during the course after discussion with te course director. Arbetsformer : The course consists of lectures, group seminars, group discussions and demonstrations.
Full time during two consecutive weeks. Examination : Written examination with a focus on understanding of concepts, relations and how and how
problems are dealt with in cancer research. Obligatoriska moment : This course is full time for two weeks. All seminars and demonstrations are
compulsory, also some lectures, as well as the written examination. Single missed occasions can be
compensated during the course after discussion with te course director.
given to earlier registration date) Övrig information : The course is scheduled full time for 2 weeks. Nonclinicians will be offered to join
Meetapatient sessions.
Kursansvarig : Svetlana Bajalica Lagercrantz
0851771797
Svetlana.Lagercrantz@ki.se
Trastvägen 24
18279
Stocksund
Kontaktpersoner : Daria Glaessgen
daria.glaessgen@ki.se
Title : Study design in clinical research
Kursnummer : 1794
Datum : 20151116 20151204
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After completion of the course the students should be able to: 1) Independently
plan and produce a study protocol including a thorough methodological evaluation and choice of appropriate
study design. 2) Critically reflect on other students individual project work in a scientifically constructive
way. 3) Interpret and critically evaluate scientific studies relevant to the course content. Kursens innehåll : The course is designed for PhDstudents, in particular those who are at an early stage
of their research education, and those with an interest in conducting clinical research. The content of the
course is as follows: 1) Basic terms in epidemiology and clinical study design, 2) Measures of disease
occurrence and incidence, causality, 3) Observational studies cohort and casecontrol studies, 4)
Systematic and random errors, 5) Experimental studies, randomised clinical trials, 6) Quality of life in
clinical research, 7) Examination and course evaluation. Throughout the course, the students will work on
an individual project (examination 1) for peerreview (examination 2). Further, students will critically
review and discuss relevant scientific articles (examination 3). Arbetsformer : Lectures, seminars, individual article review, group discussions and homework tasks will be
used. The course focuses on active learning, i.e. putting knowledge into practice and critically reflecting
upon the knowledge, rather than memorising facts. Therefore, much of the focus of the course is on the
individual project where students are required to develop a full study protocol including several important
aspects covered in the lectures, article reviews and group discussions. Students will also peerreview
eachothers projects and this will form the basis for the final examination seminar. Examination : To pass the course the student must actively participate in the course and pass the
examinations: 1) Individual project work: To develop a written comprehensive yet concise study protocol
including several important aspects study design as discussed during the course; 2) Peerreview of other
students projects followed by oral presentation own project and opposition of other students projects during
the group examination; 3) Critically review scientific articles relevant to the course content and participate
actively in the seminars. Obligatoriska moment : Compulsory attendance includes the scheduled lectures and seminars. Absence
will need to be replaced by individual assignments following discussion with the course coordinator, e.g.
article reviews, with written or oral followup.
Urval av studenter : Selection will be based on 1) Date of registration as a PhD student 2) suitability of
PhD project 3) The motivation to attend the course.
Övrig information : Kursansvarig : Nele Brusselaers
0851770942
nele.brusselaers@ki.se
UGIR Norra Stationsgatan 67
17176
Stockholm
Kontaktpersoner : Kalle Mälberg
kalle.malberg@ki.se
Title : Methods for Qualitative Content Analysis
Kursnummer : 1814
Datum : 20150929 20151125
Språk : Engelska
Kursansvarig institution : Department of Neurobiology, Care Sciences and Society
Särskild behörighet : Kursens lärandemål : After completing the course the student will be able to: * critically comment on
literature describing the development and method of content analysis. * choose an adequate design for
his/her own data. * describe the different elements of the analysis. * carry out the analysis. * critically
evaluate the weaknesses and strengths of the method of analysis.
Kursens innehåll : Development from a quantitative to a qualitative tradition of content analysis Design
and choice of analysis Different elements of the analysis Application and critically evaluation Arbetsformer : The course includes lectures, seminars and individual assignments. The students will in
project work during the whole course with support from lectures, individual literature assignments apply
content analysis in their own research and reflect on that application in a critical way. Examination : The students will finally in their project work demonstrate their knowledge and
understanding of content analysis by submitting a paper containing the use of the analysis with regard to
the learning outcomes.
Obligatoriska moment : The course in its whole needs active involvement of the students through
participation in the various types of teaching.
Övrig information : The dates for the course are: September 2930, October 2021 and November 2425,
Alfred Nobels allé 23, KI campus Huddinge. Course leaders: Kenneth Asplund and Ella Danielson
Kursansvarig : Lena Koch
Institutionen för neurobiologi, vårdvetenskap och samhälle
52483555
Lena.Von.Koch@ki.se
Kontaktpersoner : Miriam Entesarian Matsson
Miriam.Entesarian@ki.se
Title : Quality of life as an outcome measure in care sciences
Kursnummer : 1873
Datum : 20151116 20151127
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course, the students should be able to critically review research papers
describing quality of life results and to design a study with quality of life as an outcome measure. This
includes phrasing research questions, choosing appropriate instruments, timing of assessments and
procedure as well as choosing methods for analysis. Furthermore should students be able to interpret and
discuss results from studies of quality of life. Kursens innehåll : The concept quality of life and healthrelated quality of life will be discussed to give
insights into these concepts. Aditionally the criticism against these concepts and their measurement will be
addressed.The course will further include phrasing research questions, choosing appropirate instruments,
designing studies measuring quality of life (timing of assessments and procedure), choice of methods for
analysis, and interpretation of results. Arbetsformer : The course is divided in two parts, the first part consist of three fulltime days and the
second part of two fulltime days, three weeks later. The course is based on lectures during morning
sessions, which will be followed up in groupseminars in the afternoons. Between the two parts of the
course students are required to hand in one homework task which will constitute the examination. Examination : The examination consists of a review of a research proposal. The task will be introduced
during the first part of the course. Obligatoriska moment : Groupseminars are compulsory and absence from them will be made up with a
essaywriting on the topics that were to be discussed in the groupseminar. Antal studenter : 15 25
Övrig information : Course dates: November 1617, 2627. The course will take place at Alfred Nobels
Allé 23 in Huddinge. A mix of learning activities will be used such as lectures, seminars, work in
groups and individual assignments. The topics that will be covered include the concept quality of life, design
and sample selection, data collection relating to psychometric properties of the instruments the students
are using in their own research, analysis and reporting of results. Students will in groups scrutinize each
other's research proposals which will be presented the last day of the course as part of the course
examination assignment. Students are also asked to hand in a written individual assignment within one
week of the last course day. Kursansvarig : Lena Wettergren
0852483650
Lena.Wettergren@ki.se
Kontaktpersoner :
Title : Phenotyping of genetically engineered mice
Kursnummer : 1974
Datum : 20151207 20151211
Språk : Engelska
Kursansvarig institution : Comparative medicine
Särskild behörighet : Kursens lärandemål : Mål för kunskap och förståelse Efter kursen skall studenterna kunna redogöra för
fenotypning av genetiskt modifierade möss, beskriva systematisk och standardiserad fenotypsanalys av
både transgena och knock in/outmöss. Studenten skall kunna redovisa för olika strategier för framställning
av genetiskmodifierade möss, avelsproblematik, samt för tekniker och medel för undersökning av både
enklare parametrar och mer specialiserade funktioner såsom beteende, kardiovaskulär fysiologi,
neurobiologi och utvecklingsbiologi samt för djurskyddsaspekter. Mål för praktiska färdigheter Efter kursen
skall studenten kunna identifiera målorgan för fenotypanalys Efter kursen skall studenten kunna genomföra
praktiska undersökningar av genetiskt modifierade möss (obduktionsteknik). Efter kursen skall studenten
kunna identifiera och särskilja mellan olika dataanalyser.
Kursens innehåll : Denna kurs syftar till att visa hur genetiskt modifierade möss kan fenotypas på ett
strategiskt sätt; genom urval av relevanta "endpoints" och med användande av så få djur som möjligt,
genom planering av olika testar som ska genomföras. Den ger baskunskaper i systematisk fenotypsanalys
av både transgena och knockin/out möss. Kursen belyser relevanta delar av musens biologi och fysiologi,
strategier för framställning av genetiskmodifierade möss, avelsproblematik, samt redogör för tekniker och
medel för undersökning av både enklare parametrar och mer specialiserade funktioner såsom beteende,
kardiovaskulär fysiologi, neurobiologi och utvecklingsbiologi. Kursen omfattar laborationer
(obduktionsteknik), demonstrationer av olika moment. Arbetsformer : Kursen omfattar föreläsningar, laborationer, demonstrationer och grupparbete med
seminarieuppgifter. Kursen går heltid och dagtid. Kursspråket är engelska.
Examination : Lärandemål för kunskap och förståelse examineras genom redovisning av grupparbete. Obligatoriska moment : Grupparbeten och avslutande seminarier är obligatoriska. Bortvaro under kursen
kompenseras enligt instruktioner från kursansvarig.
Urval av studenter : The applicants will be first selected for the relevance of the course to their research
projects. Then will the date for registration as a PhD student have priority.
Övrig information : The course will take place at Comparative Medicine Learning Lab in Solna. It is a one
week course with full time studies. International lecturers in the subject like Cory Baryton, Associate
Professor in Molecular and Comparative Pathobiology from John Hopkins University and Björn Rozell,
Professor in Laboratory Animal Pathology at University of Copenhagen will be present among others.
Kursansvarig : Raoul Kuiper
Institutionen för laboratoriemedicin
raoul.kuiper@ki.se
Kontaktpersoner : Dude Gigliotti
Komparativ medicin
0852486529
Dude.Gigliotti@ki.se
von Eulers väg 4a, plan 4
171 77
STOCKHOLM
Title : Embryology I
Kursnummer : 1999
Datum : 20151012 20151016
Språk : Engelska
Kursansvarig institution : Department of Biosciences and Nutrition
Särskild behörighet : Kursens lärandemål : At the conclusion of this course students should be have a good understanding of: Why in vitro systems are suboptimal in producing viable human embryos relative to development in vivo Main components of the culture system (culture media, tissue culture plastics, gases, incubators,
workstations, laboratory environment, input materials) Physicalchemical properties of culture system
(osmolarity and pH of culture media, temperature, light levels) and how they can be influenced
Constitution of tubal and uterine fluids and the evolution of culture media used in ART programmes as well
as nutritional requirements of the various cell stages from gamete to blastocyst Tissue culture vessels
Functional characteristics of different tissue culture incubators Functional characteristics of different
workstations for ART and their benefits The influence of the laboratory and clinic environment on embryo
culture The influence of the quality of the input material on outcomes in ART The morphology of
oocytes, zygotes and cleavage stage embryos as well as morulae and blastocysts Developmental
milestones Predictors of developmental potential Biochemical tests for predicting developmental
potential The use of ultrasound to assess oocyte quality Student should be aware of the general
aspects and implication of the stem cells research and the potentiality that this represent for clinical
application Morphological aspects of the blastocysts for derivation of ICM and Derivation methods
Characterization of the embryonic stem cells and the importance of the pluripotency of these cells The
different differentiations assay on stem cells and what is ongoing in this field The immunorejection
problem and the production of isogonics embryonic stem cells by somatic cell nuclei transfer or therapeutic
clone (SCNT) Finally the students will improve their capacity to produce coherent, logical and concise
explanations of data and concepts both written and oral, through consideration of the course material.
Students will also develop their ability to criticize scientific literature related with ART and reproduction
physiology in a constructive and informed fashion
Kursens innehåll : Divide in lectures and laboratory work Sperm theory (lecture) 1. Anatomy of the testis,
sperm production and maturation, fertilization. 2. Cryopreservation of spermatozoa. 3. Sperm preparation
for IVF and ICSI, criteria for ICSI. Embryology ( Lecture) 1. Follicle growth and maturation, ovulation. 2.
Cell biology and oocyte genetics. 3. Embryo development invitro, morphological evaluation of embryos. 4
Cryopreservation of embryos, theory and practice. 5. Embryonic stem cells. 6. Selection of embryos for
transfer and cryopreservation. Laboratory 1. How to work with sperm, oocytes and embryos. 2.
Manipulation and training with mouse oocytes and mouse embryo handling. 3. Micromanipulation
techniques, presentation. 4. Micromanipulation training. ICSI and embryo biopsy. Genetics (Lecture) 1.
Genetic aspects of prenatal diagnostics and PGD. 2. Cloning techniques. Course test, evaluation,
discussions and closing of course.
Arbetsformer : Course organization The course runs for one weeks with lectures before lunch and practical
training in the afternoons. José Inzunza and Julius Hreinsson are responsible for organizing the lectures and
literature projects; and the practical training of the participants and the laboratory work. Teaching
laboratories at Södertörns Högskola will be used for the training in embryological techniques.
Examination : Writing individual.
Obligatoriska moment : The laboratory parts are obligatory. Not attendance of the laboratory activity;
student should present a literature work related with the subject of the missing activity.
Urval av studenter : The selection is based on the usefulness of the course for the doctoral students'
research projects, and the written motivation of the applicants, as to why they want to take the course. Övrig information : The course will be held at Karolinska Institute, Department of Biosciences and
Nutrition, NOVUM, Huddinge
Kursansvarig : Jose Inzunza
Institutionen för biovetenskaper och näringslära
08585 850 93
Jose.Inzunza@ki.se
Hälsovägen 7, Novum
141 86
Stockholm
Kontaktpersoner : Kenny Rodriguezwallberg
0858580000
kenny.rodriguezwallberg@ki.se
Reproduktionsmedicin
Karolinska Universitetssjukhuset Huddinge
141 86
Stockholm
Title : Advanced seminars in Tumor Biology
Kursnummer : 2000
Datum : 20150901 20151222
Språk : Engelska
Särskild behörighet : Kursens lärandemål : As a result of the course particiants will be able to understand and discuss
advanced problems in cell and tumor biology beyond that of textbooks. The participants will improve their
capacity to evaluate and discuss problem solving amd which methods to choose, outside their own area of
competence. In particular they shall be able to discuss and evaluate new data in these areas. Participants
will get an uptodate overview of cutting edge knowledge beyond textbooks, due to the rapid progress of
the field. This is achieved by seminars lead by national or international scientists, and with teachers among
the course organizers. Questions and discussion after the presentation by the speaker. Kursens innehåll : The course will cover the frontiers of research in some essential parts of tumor biology
and experimental oncology. Subjects that are usually covered deal with cell cycle, apoptosis, signal
transduction, cancer genetics, epigenetics incl histone regulation, cancer stem cells, proteomics incluing
ubiquitin regulation, tumor immunology, infections and cancer, mathematical modelling, angiogenesis, cell
cell communication, tumor heterogeneity, tisue biology and tumor microenvironment, new treatment
concepts, and problems in clinical cancer research. Arbetsformer : Lectures and/or seminars in groups followed by discussions including the students once a
week. Occasionally litterature studies with research articles associated with the seminars. Totally appr 18
weeks with some 20 seminars, and two meetings in a smaller group.
Examination : Written examination at the end of the course («home exam»). Questions of «essay»type to
test understanding and scientific maturity, incl some tests of subject knowledge. In addition to the home
exam the participants are evaluated according to their activity during the seminars' Q&A
sessions/discussions.
Obligatoriska moment : The seminars and the meetings in smaller groups are compulsory. Lack of
attenandance at single events will be compensated in ways agreed with the course leaders.
Övrig information : Seminars on Tuesdays every week between 13.00 appr 14.30 at Seminar room A
302, MTC, Nobels väg 16, KI Campus, Solna. In addition Bonus seminars may be offered occassionally as a
replacement for the Tuesday seminars.
Kursansvarig : Ingemar Ernberg
+46852486262
Ingemar.Ernberg@ki.se
Box 280, Karolinska Institutet
17177
Stockholm
Kontaktpersoner : Anita Göndör
08 524 862 03
anita.gondor@ki.se
Margareta Wilhelm
08524 874 74
Margareta.Wilhelm@ki.se
Elena Kashuba
08524 862 59
Elena.Kashuba@ki.se
Title : What is life? The future of biology.
Kursnummer : 2001
Datum : 20150916 20160217
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course students shall be able to discuss: 1. Theories about complexity of
biological systems 2. How biocomplexity can be studied. 3. What is the place of computational simulations
in modern biology? How simulations can be done? What the predictive power is. How mathematics can be
used in simulating biological phernomena. 4. How one understands the organizational principles of biological
systems. If selforganization is a field for study or just a trivial phenomenon. 5. How evolotionary theory
can be formalized into mathematical models. 6. If quantum mechanical theory can have a role in molecular
biology. 7. How genetic information can be converted to mechanical or electrical force in biological system. The students will also aquire an understanding of the conceptual and technical challenges in future
biomedicine and advance your ability to ask scientific questions and identify significant and possible
areas for problem solving. Kursens innehåll : Inspired by the seminal book by Erwin Schrödinger What is life? published 60 years
ago we will adress this question again, in view of the impressive development since then. There are many
new concepts to consider in the future of biology, such as the consequencies of the omics era, complexity,
computation and simulation, as well as the role of mathematicss and physics in biological theory. The
course will cover areas such as biocomplexity, quantum mechanical theory in biology, computation and
simulation (in silico biology), organization of biological systems, causality in biology, how does chemistry
become electric and magnetic forces and evolutionary theory in the light of molecular biology. Leading
scientists with an overview perspective will be invited to discuss in the seminar form the challenges that
meet us today in biology, as a result of the omics era, the availability of large amounts of data as a result
of high throughput techniques, and the possibilities provided by mathematics, simulation theory and
computational biology. Young scientists in this areas are also invited to lecture from their perspective. Invited experts will review these areas in lectures. They will also meet the students for an additional two
hours in a workshop discussion of basic concepts. Arbetsformer : Two seminars+worskhop every month for five months, 2,53 hrs on each occassion. Every
occasion consists of a appr 12 hour seminar/lecture with the invited expert followed by a two hour open
discussion, i.e 34 hours on each occassion. For each seminar the students will usually be given at least one
article on the topic to read. Active participation in discussions in groups with invited speaker of high
international standards is a key element. You also receive DVDrecordings of all lectures for further self
studies at home. Examination : Continuous by workshop discussions. Written homeexam (essay). Obligatoriska moment : The seminars are compulsory. Absence can be compensated for after discussion
with the course leader.
Övrig information : Lectures 12 times/month followed by discussion with the invited speaker, altogether
3 hrs/occassion. Venue is one of the lecture halls at KI Campus, and discussiions at the seminar room A
302 at MTC, Nobels väg 16, KI Campus, Solna.
Kursansvarig : Ingemar Ernberg
+46852486262
17177
Stockholm
Kontaktpersoner : Yvonne Strandberg
Yvonne.Strandberg@ki.se
Title : Pathology
Kursnummer : 2044
Datum : 20151019 20151030
Språk : Engelska
Kursansvarig institution : Department of Laboratory Medicine
Särskild behörighet : Kursens lärandemål : After the course the student should understand basic pathological events and be
able to analyze the connection of these events to the development of diseases.
Kursens innehåll : The course is divided into two parts. The first part illustrates cell injury, adaptation,
tissue repair and inflammation. New methods in cellular and molecular pathology will be discussed. During
the second part of the course will focus on tumor development and malignancy. We will discuss how basic
pathological responses to inflammation or injury might be the first steps on a multistep path to
malignancy.
Arbetsformer : This is a full time course with lectures, seminars, demonstrations and microscopy
exercises.
Examination : Written examination.
Obligatoriska moment : Demonstration/microscopy, microscopy practice, pathology "tour" and project
work are compulsory. Absence must be compensated with a written report.
Urval av studenter : 1)Documented knowledge in areas such as human tissue biology, cell biology or
physiology (this kind of knowledge is a prerequisite to be able to benefit from the course). Those who
already have studied pathology earlier (for example medical doctors) are not prioritized. 2)Date of
admission to doctoral studies (those who have been admitted longest time ago have priority). Övrig information : Kursansvarig : Barbro EkRylander
0858586444
Barbro.EkRylander@ki.se
Kontaktpersoner : Arja Kramsu
Arja.Kramsu@ki.se
Barbro EkRylander
0858586444
Barbro.EkRylander@ki.se
Title : Current Topics in Infection Biology
Kursnummer : 2074
Datum : 20150902 20151216
Språk : Engelska
Kursansvarig institution : Department of Medicine, Huddinge
Särskild behörighet : Kursens lärandemål : After the course, students should have increased their knowledge of various topics
within the field of infection biology such as hostpathogen interactions including viruses, bacteria, parasites
etc, innate immune factors, signalling pathways, antigen presentation, generation of cellular and humoral
immune responses, as well as aspects of vaccine and antimicrobial treatment development. The goal is
that the students to be able to critically analyze data and concepts presented at the seminars within the
course, and to discuss the data with the invited speakers. Since the lectures presented span over several
subtopics all the students should also be able to gain new information on frontline research activities
relevant for their own research project and PhD studies.
Kursens innehåll : The course is built up by a series of weekly seminars by invited speakers (international
and national) presenting their current research in infection biology. The speakers will both give a basic
introduction to their field and present their own research and discuss that in the context of the field as a
whole. The lectures will cover host/microbe interactions, routes and mechanisms of infection, the
susceptibility and the response of the host to such infections, and the molecular and physiological events
leading to the clearance of microbes or a diseased state. Innate and adaptive immunity, inflammation, and
the biology of membranes and receptors will also be presented and discussions. Arbetsformer : The seminars are one hour long and are held weekly as part of a seminar series held. A
total of 1520 seminars will be held during the semester.
Examination : To ensure that the examination is at the individual level, each student is required to read
the review articles provided by each speaker and summarize and critically analyze one seminar in a written
report.
Obligatoriska moment : Attendance at the seminars is compulsory to pass the course. If a student is
unable to attend some seminars, she/he can compensate by summarizing and analyzing additional
seminars in a written report to make up for the absence.
Övrig information : Seminars will be held on Wednesday 13.0014.00 at the Center for Infectious
Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge.
Kursansvarig : Yenan Bryceson
+46858581158
Yenan.Bryceson@ki.se
Centrum för Infektionsmedicin, F59
14186
Stockholm
Kontaktpersoner :
Title : Forskningsetik
Kursnummer : 2132
Datum : 20150825 20150915
Språk : Svenska
Kursansvarig institution : Department for Clinical Science, Intervention and Technology
Särskild behörighet : Kursens lärandemål : Få en inblick i och förståelse av centrala forskningsetiska teorier, principer och
riktlinjer och därmed få möjlighet att reflektera över etiska aspekter av den egna forskningen. Målet är
också att den forskarstuderande ska få en bättre förståelse av vad som är god vetenskap samt var
gränserna går för vad som är etiskt oacceptabel forskning både vad gäller försök med människor och med
djur, samt vad som gäller för forskarens egen hederlighet. Kunskap och förståelse: Den forskarstuderande
ska efter att ha gått kursen kunna 1. redogöra för forskningsetiska teorier, principer och till viss del
riktlinjer, 2. visa kunskap angående vanliga forskningsetiska problemsituationer och de etiska verktygen
som kan användas för att hantera forskningsetiska konflikter Färdigheter: Den forskarstuderande ska efter
att ha gått kursen kunna: 1. analysera forskningsetiska konflikter, 2. ge hållbara forskningsetiska
argument för eller mot ett förfarande Förhållningssätt: Den forskarstuderande ska efter att ha gått kursen
ha: 1. utvecklat ett forskningsetiskt förhållningssätt till andra forskarstuderande, handledare och seniora
forskare, 2. förståelse för hur ett etiskt förhållningsätt uppfattas hos allmänheten Kursens innehåll : Att ge en introduktion till etiken i samband med forskning och en orientering om dess
tillämpning på problem inom det vetenskapliga området. Kursen behandlar bl.a. följande teman: centrala
etiska principer, teorier och argument, forskningsetik/forskaretik, grundläggande värderingar och normer
för god sed i forskningen, innehåll i och värdet av regelverk så som Helsingforsdeklarationen dess funktion,
tillämpning, möjligheter och begränsingar, etikprövningar, avvikelser från värderingar, forskningsfusk och
vetenskaplig oredlighet. Det informerade samtyckets historia och komponenter. Försöksdjursetik,
innefattande argument för och emot att använda olika djur för forskningsändamål samt de 3 R:en.
Hantering av vetenskapligt författarskap (medförfattarskap, författarordning) och intressekonflikter i
forskningen.
Arbetsformer : Föreläsningar (ca 6t), gruppövningar, seminarier(ca 8t) och muntlig och skriftlig
presentation
Examination : Examination består av aktivt deltagande i seminarier, ett kortare skriftligt PM där ett tema
inom ramen för kursen behandlas. Detta PM presenteras också muntligt för de andra kursdeltagarna.
Doktoranden förväntas relatera temat till det egna avhandlingsarbetet. Godkänd kurs innebär aktivt
deltagande i seminarier och godkänd muntlig och skriftlig presentation av examinationsuppgiften. Obligatoriska moment : Obligatoriskt är att delta vid introduktionstillfället och vid seminarier. Vid
frånvaro kan detta kompenseras med utökat PM skrivande och muntlig presentation för kursen eller
kursgivare.
Övrig information : Kursansvarig : Sigridur Kalman
Institutionen för klinisk vetenskap, intervention och teknik
08585 817 87
sigridur.kalman@ki.se
Kontaktpersoner : Carol Melton
carol.melton@ki.se
Title : Vetenskapsteori
Kursnummer : 2133
Datum : 20151006 20151201
Språk : Svenska
Särskild behörighet : Kursens lärandemål : Efter kursen skall kursdeltagaren ha en bred kunskap i vetenskapsteori samt
förmågan att självständigt reflektera över och kritiskt diskutera vetenskapsteoretiska problem i
vetenskapligt arbete, för både den egna forskningsuppgiften och forskning i allmänhet.
Kursens innehåll : En introduktion till vetenskapsteorin och en förståelse för olika slag av vetenskapligt
kunskapssökande. En grundläggande orientering om vetenskapsteoretiska frågor ges. Följande teman
behandlas: begreppet kunskap, vetenskap pseudovetenskap, hypoteser hypotesprövning, orsaker
förklaringar, vetenskap ¿ värderingar samhälle.
Arbetsformer : Föreläsningar (ca 12 t), gruppövningar, seminarier (ca 14 t) och muntlig och skriftlig
presentation.
Examination : Examination består av aktivt deltagande i seminarier, i ett skriftligt PM där ett tema inom
ramen för kursen fördjupas och behandlas mer utförligt, och genom att detta PM presenteras muntligt för
de andra kursdeltagarna. Doktoranden förväntas relatera temat till det egna avhandlingsarbetet, alternativt
andra (centrala) forskningsfrågor inom den egna disciplinen.Godkänd litteraturredovisning vid seminarier
samt godkänd muntlig och skriftlig presentation av examinationsuppgift krävs för godkänd. Obligatoriska moment : Obligatoriskt är att delta vid introduktionstillfället och vid seminarier. Vid
frånvaro kan detta kompenseras med utökad muntlig och skriftlig presentation vid seminarium eller för
kursgivaren.
Övrig information : Kursansvarig : Sigridur Kalman
08585 817 87
sigridur.kalman@ki.se
Kontaktpersoner : Carol Melton
carol.melton@ki.se
Title : Infectious Disease Epidemiology
Kursnummer : 2135
Datum : 20151012 20151016
Språk : Engelska
Särskild behörighet : Knowledge in epidemiology and biostatistics equivalent to "Epidemiology I:
Introduction to epidemiology" and "Biostatistics I: Introduction for epidemiologists", respectively, or
corresponding courses.
Kursens lärandemål : Participants are expected to have a basic knowledge of epidemiological tools, and
the course aims to show how these tools apply to the study of infectious diseases. After successfully
completing this course you as a student are expected to be able to: explain the concepts and terms used
in infectious disease epidemiology list the steps of an outbreak investigation describe the functions and
problems of a surveillance system design a simple model for an epidemic explain how population mixing
patterns influence epidemic spread design a study to test the effectiveness of a vaccine discuss the
important determinants of the antimicrobial resistance problem discuss national and EU systems to control
infectious diseases Learning outcomes are classified according to Bloom's taxonomy: knowledge,
comprehension, application, analysis, synthesis, and evaluation. Kursens innehåll : Definitions; immunity; transmission routes; outbreaks; vaccinology; surveillance;
models and mixing patterns; specific examples, such as antimicrobial resistance; control systems.
Arbetsformer : Lectures, group discussions, computer simulations, case studies.
achieved. Assessments methods used are group assignments along with written and oral individual tasks.
Students who do not obtain a passing grade in the first examination will be offered a second examination
within two months of the final day of the course. Students who do not obtain a passing grade at the first
two examinations will be given top priority for admission the next time the course is offered
Obligatoriska moment : Only the examination tasks are compulsory. Antal studenter : 12 25
Övrig information : Kursansvarig : Johan Giesecke
0858601210
Johan.Giesecke@ki.se
08524 822 93
Title : To communicate science in different contexts
Kursnummer : 2144
Datum : 20150916 20151001
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course the student is expected to be able to: 1. Orally present own
research adapted to different target groups. 2. Reflect on presentation skills and ability to adapt to different
target groups.
Kursens innehåll : During the course each participant will be given the opportunity to develop practical
and theoretical knowledge in: Communication, perception and learning Presentation techniques
Rhetoric Use of different media (such as Posters, Overheadprojector, PowerPoint, Whiteboard) Each
course participant will perform three oral presentations and receive feedback on content, presentation skills
and adaptation towards target group.
Arbetsformer : The course design is based on reflective practice and includes selfdirected learning,
lectures and literature seminar to process theoretical knowledge, and practical training in presentation
skills.
Examination : The assessment consists of two different tasks: 1. Reflective statement based in
experience, feedback and research/literature within communication and learning. 1. Oral presentation in a
popular scientific context supported by PowerPoint or similar. To pass the course the participant needs to
show evidence that they reached the learning outcomes by fulfillment of the assessment criteria. Obligatoriska moment : Compulsory sessions are: 1. Oral presentation in a popular science context
(video recorded) 2. Oral presentation in a scientific context and observe and give feedback to an oral
presentation made by a peer. Absence from the compulsory sessions or assessment seminar can be
compensated through supplementary activity.
Urval av studenter : The selection for this basic general science course will be based on your admission
date to doctoral education (priority given to earlier registration date). Please make sure that you have
entered the correct registration date for doctoral education in your personal profile. Övrig information : This is a two week course which requires time for independent work outside of
scheduled class time. Scheduled class room sessions are on the following dates: 1617 September, 2324
September, 30 September and 1 October. The course is given in ENGLISH.
Kursansvarig : Cormac Mcgrath
cormac.mcgrath@ki.se
Kontaktpersoner : Ingrid Smedberg
08524 837 89
ingrid.smedberg@ki.se
Title : Cardiovascular Epidemiology
Kursnummer : 2154
Datum : 20151019 20151023
Språk : Engelska
Särskild behörighet : Kursens lärandemål : Students having successfully completed the course are expected to recognize
different risk factors or risk indicators for cardiovascular disease and different cardiovascular phenotypes.
Students should be able to discuss the study designs most commonly used within cardiovascular
epidemiology. In addition, students should be able to interpret study results critically.
Kursens innehåll : Overview and discussion of risk factors/risk indicators environmental, genetic and
biochemical. Discussion of theories and concepts related to common epidemiological and genetic study
designs cohort, casecontrol, and genetic association studies. Arbetsformer : Lectures (cathedral) Group work, to consolidate and reflect upon concepts introduced
during the course. Seminars. Examination : Learning outcomes will be assessed using 1) a short individual written examination covering
different research methods used within cardiovascular epidemiology, and 2) a written group examination.
Obligatoriska moment : Participation in group work and article seminars is mandatory. Compensation
through an individual written assignment.
Urval av studenter : Eligible doctoral students will be prioritized according to 1) the relevance of the
course for their research 2) the stated motivation for attending the course. We carefully consider your
motivation to attend the course. There will be no selection based upon type of education and background
knowledge, however we will use this information to divide student in groups for the group works, so please
indicate it in your application.
Övrig information : The course takes place at the Institute of Environmental Medicine (IMM), from 9 am
till 4 pm Monday to Friday. There will be lectures in the morning and group works in the afternoon.
Kursansvarig : Karin Leander
0852487498
Karin.Leander@ki.se
Box 210 (Nobels väg 13), KI
171 77
Stockholm
Title : Basic Tumor Histopathology
Kursnummer : 2166
Datum : 20150914 20150925
Språk : Engelska
Särskild behörighet : Kursens lärandemål : At the end of the course the participants should be able to: Distinguish normal
from malignant cells in tumor tissues and be acquainted with the morphology/histology of the different
tumor types, differentiation stage and tumor grade. Recognize cellular processes in the tumor tissue and
its microenvironment like mitosis, cell proliferation, pleomorphism, lineage differentiation, tumor stage,
necrosis, apoptosis, neural and vascular invasion, vascularisation. Understand ethical issues and legislation
concerning biobanking and practical issues on tumor handling.
Kursens innehåll : Tumor histopathology and grading. Introduction. Endocrine tumors. Breast tumors. Prostate tumors. Gastrointestinal tumors. CNS tumors. Hematological malignancies. Sarcoma. Gynecologycal cancers. Tumor handling and biobanking.
Arbetsformer : The first day will include an introductory lecture covering general aspects of tumor
morphology/histopathology and grading. In the following days we will review one tumor diagnosis per day
organized in 45 min introduction , followed by 2 hrs interactive microscopy sessions using a multiheaded
microscope and a digital screen, guided by pathologists expert in each field. Home exercises consisting on
digital images of tumors together with the clinical history are given at least twice to the students for
training. For distribution of files and examination we use KI Box.
Examination : The students will get different case studies including digital images from tumors tissues and
their clinical history via the KI Box account of the course. The students will then examine the cases and
provide a writen description of the relevant observations leading to a correct diagnosis and answers. Images and questions have been provided by each teaching pathologist. When appropriate, antiplagiarism
tools will be used according to the guidelines from the Board of Doctoral Education at KI. Obligatoriska moment : 100% attendance is recommended, due that each session is exclusive and
cannot be compensated for later on. The student will be asked to review the issue presented in case of
absence in a session.
Övrig information : The lectures take place at the lecture hall at Cancer Centrum Karolinska or
Radiumhemmet. The microscopy session take place at the Division of Tumor Pathology, at Radiumhemmet.
Entrance from CCK floor 2.
Kursansvarig : Bertha Brodin
51775244
Bertha.Brodin@ki.se
Cancer Centrum Karolinska CCK R8:00
171 76
Stockholm
Kontaktpersoner : Bertha Brodin
0851775244
Bertha.Brodin@ki.se
Title : Cellular and molecular infection biology
Kursnummer : 2176
Datum : 20151026 20151106
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course the students will have an overview of the various aspects of
microbial infections with bacteria, viruses and parasites. The students will have knowledge on the level of
current understanding of the cellular and molecular mechanisms used by pathogenic microbes, since the
course will provide "stateoftheartlevel" presentations in selected aspects of a hostpathogen interaction.
The students will be able to give examples of interdisciplinary studies in the research field of microbehost
interactions, many lectures focus on interdisciplinary themes such as microbecell interactions, microbial
manipulation of host inflammatory responses, pathogen transmission and novel techniques to study
microbehost interactions. Analytical and critical thinking will be encouraged by the course design. The
students will also have an improved capability for scientific discussions, since the course provides the
possibility to interactive discussions with invited teachers, who will attend the student presentation. After
the course the students will have a more holistic picture of infection biology, and hopefully they will be
encouraged to apply such new information for the benefit of their further graduate training and even get
significant input for their own research. Kursens innehåll : Microbial pathogenesis, the interplay between microbes and various host responses
and transmission of pathogens
Arbetsformer : The course consists of lectures by inhouse and invited speakers on various topics in the
discipline of cellular and molecular infection biology. Presentations will cover basic aspects of the research
topic that will provide the students with a foundation in the subject. In addition, the more advanced part of
the lecture will present stateoftheart research. Groups of students will prepare a seminar and another
group will act as ¿opponents¿ to critically analyse the presentations. The students will subsequently
participate in interactive studentdriven discussions which includes the invited teacher.
Examination : The students will be assigned a series questions based on topics that have been discussed
during the course in a written examination.
Obligatoriska moment : The compulsory parts of the course are preparation and attendance of the
lectures and the student group presentations. If the students cannot attend a lecture they should write a
summary based on the course literature for this lecture. There will be a written examination at the end
where the students should discuss a given problem within microbial pathogenesis and microbehost
interactions.
Övrig information : The course will be held at the Department of Microbiology, Tumor and Cell Biology
(MTC). It will include lectures from International, National and local researchers in the fields of Bacteriology,
Virology and Parasitology. Kursansvarig : Keira Melican
Institutionen för neurovetenskap
Keira.Melican@ki.se
Kontaktpersoner : Benjamin Libberton
benjamin.libberton@ki.se
Gerald McInerney
08 52486951
Gerald.Mcinerney@ki.se
Nobels väg 16
17177
Stockholm
Keira Melican
Keira.Melican@ki.se
Title : How to make genetically modified mice for immunological
research
Kursnummer : 2186
Datum : 20150907 20150911
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After taking the course the student should have an in depth knowledge of how to
make genetically modified mice. In summary, the student will aquire enough practical and theoretical
knowledge to allow them to independently make genetically modified mice. Specifically, the student will
know how to design and make DNA constructs for gene targeting and transgenesis, how to design and
perform genotyping using Southern blotting and PCR, and finally how to use the modified mice in
immunological experiments. Furthermore, after the course the students will know how to critically analyse
experiments presented in the scientific literature and judge their scientific quality. Kursens innehåll : 1) Gene targeting and transgenesis in general: a) a short history of gene targeting and
transgenesis in mice, b) when is gene targeting or transgenesis suitable for immunological experiments?, c)
overview of the work process. 2) Designing and making constructs for gene targeting and transgenesis. a)
how to obtain the necessary information for designing a gene targeting construct, b) different approaches
to make DNA constructs for gene targeting and transgenesis 3) Conditional gene targeting. 4) Common
problems in gene targeting and transgenesis, and how to solve them. 5) How to use genetically modified
mice in immunological research Arbetsformer : Lectures will be the main form of teaching during the course. However, a workshop and a
homework assignement will also be part of the course. In groups of three, the students will design a gene
targeting project from start to finish and present their research plan.
Examination : Active participation in the workshop and the scientific quality of the homework assignement
will be the main criteria for the examination of the students.
Obligatoriska moment : The homework assignement is compulsory. The homework can alternatively be
handed in later in written form.
Övrig information : Kursansvarig : Alexander Espinosa
Alexander.Espinosa@ki.se
Kontaktpersoner : Lisa Westerberg
Lisa.Westerberg@ki.se
Alexander Espinosa
Alexander.Espinosa@ki.se
Title : Developmental biology for regenerative medicine
Kursnummer : 2188
Datum : 20150831 20150911
Språk : Engelska
Kursansvarig institution : Department of Cell and Molecular Biology
Särskild behörighet : Kursens lärandemål : After the course, the students should know the basics of stem cell biology and the
medical use of cell therapy. The students should be able to describe and understand the theoretical basis
for key technologies utilized in stem cell research.
Kursens innehåll : The course covers key concepts in translational research from the laboratory to the
clinic, including an advanced review of descriptive and molecular developmental biology.
Arbetsformer : The pedagogic learning activities on the course consist of cathedral lectures, group
discussions and student presentations.
Examination : The students are examinated individually with a quiz or a written essay. The final course
examination is a project presentation in groups.
Obligatoriska moment : Participation in the group discussions and student presentations is mandatory.
Compensation through an individual written assignment.
Övrig information : The course is organized by the Research School of the Linné Center DBRM
(Developmental Biology for Regenerative Medicine). More course information can be found at the Research
School web pages at www.dbrm.se. The course is full time and the course venue is the seminar room A216
at CMB, Berzeliusv 35.
Kursansvarig : Matti Nikkola
Institutionen för cell och molekylärbiologi
Matti.Nikkola@ki.se
Kontaktpersoner :
Title : Live cell imaging
Kursnummer : 2283
Datum : 20151005 20151016
Språk : Engelska
Särskild behörighet : none
Kursens lärandemål : After passing the completed course, the students will be familiar with the basic
principles of fluorescence microscopy and diverse live cell imaging techniques. They will be competent in
independently designing and performing live cell imaging experiments and understand the
possibilities/limitations of different live cell imaging techniques.
Kursens innehåll : Basic principles of fluorescence microscopy and live cell imaging. Confocal Laser
Scanning Microscopy Deconvolution fluorescence Microscopy Basic principles of advanced fluorescence
techniques. Design and perform live cell imaging experiments. Data analysis and presentation. Arbetsformer : The pedagogic learning activities on the course consist of lectures, research seminars,
laboratory work (imaging), group discussions, data processing and student presentations.
Examination : The students are examinated through 1) an individually written assigment (case study), 2)
a practical session and 3) a poster presentation. Obligatoriska moment : All activities (lectures, research seminars, laboratory work, group discussions,
data processing and student presentations) are compulsory. If students are unable to attend they have to
discuss with course organizer how this can be compensated. Compensation of the laboratory work is not
possible.
Övrig information : The course will cover theoretical and practical work on different fluorescence
microscopes (confocal laser scanning microscopy, deconvolution fluorescence microscopy, grid confocal
microscope) focused on live cell imaging with the application of various fluorescence techniques
(Fluorescence Restoration After Photobleaching, Fluorescence Loss Induced by Photobleaching,
photoactivation, fluorescence resonance energy transfer). The course includes introduction lectures, 23
research seminars from international speakers, and handson sessions at different fluorescence
microscopes.
Matti.Nikkola@ki.se
Kontaktpersoner :
Title : Clinical achievements of reproductive medicine
Kursnummer : 2291
Datum : 20150921 20150925
Språk : Engelska
Särskild behörighet : Kursens lärandemål : The objectives of this course are that at the conclusion of this course students
should be able to have a comprehensive view of: The key factors involved in gamete biology, gamete
physiology and in vivo and in vitro fertilization The key factors involved in early embryo development and
implantation The clinical achievements of modern reproductive medicine and Assisted Reproduction
Techniques (ART) The causes of subfertility and infertility and the current therapeutic approaches The link
between genetics and male/female infertility and the implications in ART The difference between
chromosomal and DNAbased genetic disease and the different technologies to detect them The basic
genetic technology used in Preimplantation Genetic Diagnosis (PGD) The in vitro systems, culture systems
and work stations used in ART The influence of the laboratory and clinic environment on embryo culture
The assessment of developmental potential and the morphological aspect of normal oocytes, zygotes,
cleavage stage embryos, morulae and blastocysts The implantation process The pathophysiology of
repeated early pregnancy loss and ectopic pregnancy The general aspects, implication and clinical
applications of stem cells research The novel development of ART for fertility preservation, cryobiology
and transplantation The epigenetic aspects of assisted reproduction Kursens innehåll : Contents: Biology of the gametes, fertilization and early embryo development Normal
and pathological implantation, early pregnancy loss, ectopic pregnancy, repeated miscarriage In vitro
spermatogenesis and oocyte maturation Clinical investigation and therapeutic approach on female and
male infertility Genetics in infertility Gonadal dysgenesia Stem cells research Assisted reproduction
techniques (ART) In vitro systems and cultures Cloning. Somatic cell nuclear transfer Clinical aspects of
fertility preservation Cryobiology systems for fertility preservation Preimplantation genetic diagnosis Epigenetics in assisted reproduction Experimental reproductive tissue transplantation procedures: ovarian
and testicular tissue transplantation transplantation of the uterus Arbetsformer : lectures, seminaries/discussion and laboratory demonstrations Examination : Written examination and discussion Obligatoriska moment : All teaching activities, the laboratory sessions and the lectures are obligatory. In
case of not attendance to the activities, students should produce a literature work related with the subject
of the missing activity.
Övrig information : The course is oneweek fulltime and includes laboratory demonstration and visits to
the reproductive medicine clinics at Karolinska Unversity Hospital, Huddinge. Speakers are international
authorities in clinical and experimental research in reproductive medicine
Kursansvarig : Kenny Rodriguezwallberg
0858580000
141 86
Stockholm
Kontaktpersoner : Kenny Rodriguezwallberg
0858580000
141 86
Stockholm
Jose Inzunza
08585 850 93
Jose.Inzunza@ki.se
Hälsovägen 7, Novum
141 86
Stockholm
Title : Basic immunology
Kursnummer : 2302
Datum : 20150915 20151029
Språk : Engelska
Särskild behörighet : Kursens lärandemål : To understand basic principles of innate and adaptive immunity and how different
components of the immune system cooperate. To be able to relate, compare and understand experimental
aspects of immunerelated disease in a clinical perspective. To adapt knowledge gained of the function of
the immune system by being able to analyze and discuss an immunological/clinical case (group project). To present the group project and discuss the results as well as work in pairs with clinical cases.
Kursens innehåll : The course is separated into two parts. In part 1 we discuss basic immunological
mechanisms within the innate and adaptive immune response. In part 2 we apply the knowledge in clinical
settings such as defence against infection, autoimmune and allergic disease or transplantation. Part 1: Introduction An overview of the immune system T cells B cells Antigenpresenting cells Innate vs
adaptive immune responses Methods to study immune reactions. Part 2: Immune defence against
bacterial and viral infections Primary immunodeficiencies Autoimmune disease Allergy Vaccination Clinical Immunology Transplantation Tumour Immunology Questions and discussions Presentation of
projects. Arbetsformer : The course is given fulltime during a total of six days separated into two parts. The
teaching is mainly in lecture/seminar form but also includes project work studying cases individually and
pairwise, as well as in small groups. The group projects are then presented orally on the last day of the
course. The project work requires studies between the two course parts, including meetings with mentors.
Course literature (Abbas) and cases are handed out at the course start. An immunological quiz is connected
to the different chapters in the book so that the student will be able to digest the relatively big material. The course is designed so that clinically active doctors will be better able to combine it with work in the
clinic (Mondays and Fridays contain no scheduled course work) .The purpose of dividing the course into two
parts is that the participants should have time to thoroughly study the literature from part 1 (fundamental
immunological mechanisms) before teaching of the applied immunology in part 2 starts. Considering the
substantial literature requirement plus the cases and project work, we estimate that an extra 32h of study
is needed, which is not included in the schedule. Examination : Webbased exam on the course content. Oral presentations of smallgroup project work. At
this occasion special attention is given to that all students are actively participating. The clinical cases are
examined by written reports. Obligatoriska moment : Project work and attendance at the project presentation is compulsory as well as
work with two clinical cases. In the case of absence a separate occasion is organized with presentation for
the course organizers. The webbased exam is mandatory. Antal studenter : 12 45
Urval av studenter : Selection of students is based on 1. Date of registration as doctoral student
2.Motivation to attend the course.
Övrig information : The course is divided into two parts, consisting of three days each (Tuesday to
Thursday 1517 September and 2729 October). Between the two parts the participants perform project
work, including meetings with mentors as well as study the literature. Teachers include specialists in
different fields of immunology including both basic and clinical researchers: examples: Peter Bergman, Ola
Winqvist, Rolf Kiessling, Helena Erlandsson Harris and Guro Gafvelin. Litterature includes Abbas (Basic
Immunology) the book is free and is handed out at the course start and clinical cases as well as
handouts etc. The course location is at or near the Center for Molecular Medicine (CMM), Karolinska
University Hospital in Solna. Kursansvarig : Jan Wahlstrom
0851770663
Jan.Wahlstrom@ki.se
Lungforskningslab L4:01
Karolinska Universitetssjukhuset, Solna
171 76
Stockholm
Kontaktpersoner : Tina Heyder
Tina.Heyder@ki.se
Title : Functional Fluorescence Microscopy Imaging (fFMI) in
biomedical research
Kursnummer : 2348
Datum : 20151102 20151113
Språk : Engelska
Särskild behörighet : Kursens lärandemål : At the end of the course the student should be able: 1. to use fundamental aspects
of molecular structure to describe molecule (matter) interaction with light (electromagnetic radiation) and
the emission of fluorescence, and to use this knowledge to discuss fluorescent properties of a fluorophore
and different labeling strategies. 2. to understand the fluorescence imaging instrumentation, to define
elements of a fluorescent microscope and to describe instrumentation properties in terms of sensitivity. 3.
to describe the theoretical background behind fluorescence based methodologies for studying molecular
interactions in live cells. Discuss pros and contras in relation to the biological problem studied. 4. to specify
instrumental requirements and to design a fluorescence imaging assay for a biological problem of interest. 5. to apply a specific labeling strategy and perform a live cell fluorescence imaging assay. 6. to document
experimental work in accordance with Good Laboratory Practice (GLP) guidelines. 7. to communicate the
results in written and oral form. 8. to discuss the adequateness of the methodology used in the scientific
literature concerned. Kursens innehåll : Fluorescence microscopy and associated techniques are becoming indispensable
research tools for investigating molecular mechanisms of biological processes. Versatility of fluorescence
based methodologies comes from the multifaceted possibility to characterize fluorescence emission by
position, intensity, wavelength, lifetime and polarization. These methodologies bring new biological insight
at an unprecedented rate and are of crucial importance for the development of life sciences. The course
covers the following topics: Luminescence and the nature of light (Fluorescence, Phosphorescence, Light
scattering, RayleighTyndall scattering, Raman scattering); Fluorescent markers and their photophysical
properties (Organic fluorescent dyes for covalent conjugation (Rhodamine 6G, Alexa dyes, Cyanine dyes);
Quantum dots; Intrinsically Fluorescent Proteins (Aequorea victoria (GFP, YFP), Discosoma coral (DsRFP)
and Montipora (Keima) families); Selectively binding and intercalating dyes (DiI, DraQ 5). Labeling
strategies for biomedical application. Instrumentation for fluorescence imaging (Light sources, Wavelength
selection, Detectors, Readout devices, Sample holders, Problems of high blank values, Cuvettes, Solvents
and Reagents, Other contaminants); Quantitation and Sensitivity (Instrumental sensitivity, Method
sensitivity, Absolute sensitivity); Factors affecting quantitative accuracy (Adsorption, Photodecomposition,
Oxidation, Temperature, pH, Innerfilter effects, Quenching); Fluorescence based methodologies for
studying molecular interactions in live cells (FRET, FLIM, FRAP). Singlemolecule detection (Quantitative
APD imaging, FCS and FCCS). Nonlinear microscopy (Multiphoton excitation, STED). Spatially resolved
fluorescence imaging (STORM, PALM). Arbetsformer : The course includes lectures, laboratory sessions, discussion sessions and a project work.
Examination : The final assignment consists of a written project report (5 pages) and an oral presentation
of the project report (15 min). Obligatoriska moment : All sessions are compulsory. Please report any absence to the course leader in
advance by email. Absence from any part of the course (lectures, laboratory sessions, discussion sessions
and exam) is generally not accepted but could in special cases be compensated by an individually tailored
additional module and a special written examination organized by the course committee.
Urval av studenter : This course is on advanced fluorescence microscopy imaging and spectroscopy
techniques for quantitative study of molecular transport and interactions in live cells. Number of
participants is limited to 12. Priority will be given to applicants who can concisely (max 250 words) show in
their application an urgent need to begin their independent work with these techniques. Övrig information : This is a two week course, with 10 sessions. Each session includes a lecture (1 h),
laboratory practice and discussions (3 h) and time for selfstudy. Last session is reserved for assessment.
 The total working load for the students is estimated to be 95 h (3 hp). Experimental
exercises are carried out in the fFMI laboratory CMM, L5:02, 020a. Lectures are conducted in the
lecturing hall CMM L8:01, 021.
Kursansvarig : Vladana Vukojevic
51771797
Vladana.Vukojevic@ki.se
CMM L8:01
17176
Stockholm
Kontaktpersoner :
Title : Survey of Molecular Endocrinology
Kursnummer : 2381
Datum : 20150928 20151009
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After successfully completing this course, student should have obtained a
fundamental knowledge of molecular endocrinology and acquired the following abilities: 1. explain the
molecular mechanisms by which peptide and steroid hormones activate their receptors to provoke their
biological effects 2. comprehend how the actions of hormones are involved in diseases 3. construct
pathways of the endocrine systems that link control and production of hormones in specific tissues with the
actions of these hormones in their respective target organs 4. analyse and evaluate scientific reports within
the research field of molecular endocrinology 5. develop an indepth comprehensive knowledge of
endocrinology from a physiological, cellular, and molecular perspective 6. incorporate knowledge learned
from this course to critically evaluated clinical and research case problems relating to molecular
endocrinology mechanisms 7. evaluate clinical, translational and basic research articles critically and
conceptualize alternative interpretations approaches and theories from primary molecular endocrine
principles learned in the course 8. structure principles endocrine concept proposal in hypothesis driven
objectives for a research grant 9. prepare for public speaking infront of a scientific audience Kursens innehåll : This course will cover current topics involved in hormone signalling at a cellular and
molecular level from receptor interaction to gene response including receptor structure and function
interactions with their hormone, second messengers, transcription regulation and autocrine and paracrine
feedback signalling pathways. The course will emphasize the critical understanding of how hormones act
at the molecular level and why their signalling pathways synergize or antagonize each other under normal
and pathological physiological conditions. A survey of current topics in endocrinology will be used to
exemplify the concepts of the course such as stem cell commitment and differentiation, the molecular
signalling and genetics of embryogenesis; reproductive determination and differentiation; cancer stem cell
dedifferentiation and carcinogenesis; hormonal regulation of gene expression, steroid and peptide hormone
action via paracrine, autocrine signalling; endocrine mechanisms of receptor interaction, transmembrane
and intracellular signal transduction, ionic signalling, and regulation of nuclear gene transcription. Arbetsformer : The course will consist of cathedralstyle lectures to exposure students to fundamental
molecular endocrine concepts, current topic seminars to exemplify concepts, and studentled seminars and
discussions to allow the students an opportunity to utilize conceptual knowledge within an informal
environment. Examination : 1. One studentled presentation and discussion with chosen student partner Teams of two
students each will be assigned a current journal article with an emphasis in molecular endocrinology to
present to the rest of the class. All articles will be read by the students prior to the presentation. Each team
will be assigned a faculty member who will supervise their preparation and understanding of the article to
be presented at an assigned date during class. Each team will make a formal presentation on the article and
will review, critique and discuss alternative interpretations of the article. (Learning outcomes 4, 6, 7, and 9) 2. one written peer evaluation report Each student will be assigned one team led presentation to critique
both presenters and journal article. The critique will be formulated in a grant style format. The student will
be expected to review the specific topic within molecular endocrinology that the article emphasizes. Then
create a testable question and develop a hypothesis based on the topic. Then develop a methodological
approach to prove the hypothesis. The student teams that present the article will be considered experts in
that topic and the student will critique their position with in the field. (Learning outcomes 4, 6, 7, and 8) 3.
one final exam The final written exam will assess the fundimental principles in the following learning
outcomes 1, 2, 3, and 5. Obligatoriska moment : The students are expected to attend all lectures and seminars. They are
expected to actively participate in discussions. Missed sessions may be replaced by written tasks adapted to
the situation. Antal studenter : 5 25
Övrig information : This course will be located on the Solna campus. During lecture days, lectures will be
held between 1014. Kursansvarig : John Flanagan
0704816995
john.flanagan@ki.se
CMM, L8:01
Andrology and Molecular Endocrinology Units
171 76 Solna
Kontaktpersoner :
Title : Aktuell Omvårdnadsvetenskap teori och praxis
Kursnummer : 2407
Datum : 20151002 20151120
Språk : Svenska
Särskild behörighet : Tidigare studier inom vårdområdet och närliggande områden i förhållande till
forskningsprojektets inriktning.
Kursens lärandemål : Kursen syftar till fördjupning i omvårdnadsämnets begreppsliga och teoretiska
grunder, samt granskning och värdering av aktuell omvårdnadsvetenskaplig forskning. Mål för lärande är
studerandes tillägnan av omvårdnadsvetenskaplig begrepps och teorigrund samt pågående
omvårdnadsvetenskapliga paradigm och diskurser. Studerande ska kunna ställa samman
vetenskapteoretiska grunder för teori och begreppsutveckling inom omvårdnad samt kunna tillämpa detta i
relation till egen forskningsinriktning. Studerande ska kunna förklara den historiska utvecklingen av
omvårdnad som vetenskap och kunna sammanfatta för innehållet i utvalda omvårdnadsteorier Studerande
ska kunna kritiskt granska, analysera och värdera utvecklingen av omvårdnadsvetenskapliga begrepp
relaterat till egen forskningsinriktning. Kursens innehåll : Vetenskapsteoretiska aspekter på omvårdnadsvetenskap Teoriutveckling och
begreppsutveckling inom en vetenskap Metateoretiskt perspektiv enligt Meleis Den Nordiska utvecklingen
av omvårdnad/vårdvetenskap Granskning och värdering av aktuell omvårdnadsforskning samt pågående
teoriutveckling Arbetsformer : Målen bearbetas genom att studera internationell och Nordisk utveckling av
omvårdnadsvetenskap. Exempel studeras på olika forskningsprogram inom omvårdnad vårdvetenskap. Vi
bekantar oss med, analyserar och granskar kritiskt, paradigmutvecklingen inom ämnet idag. Kursen bygger
på en huvuddel av självstudier av litteratur. Arbetsformerna på campus är seminarier samt föreläsningar. Examination : Litteraturuppgifter på obligatorisk kurslitteratur samt integrativ granskning och analys av
omvårdnadsteoretiska grundbegrepp i relation till eget projekt. Obligatoriska moment : Undervisningsmomenten på campus, föreläsningar och seminarier under kursen
är obligatoriska. Frånvaro kompenseras genom skriftliga eller muntliga extrauppgifter vilka beslutas av
examinator. Antal studenter : 15 30
Övrig information : HT 2015 kommer fredagarna 2/10, 16/10, 6/11 och 20/11 vara obligatoriska campus
samlingar för kursen. Kursen ges på Alfred Nobels Alle 23 i Huddinge (tågstation Flemingsberg).
Kursansvarig : Maria Arman Institutionen för neurobiologi, vårdvetenskap och samhälle
0852483973
Maria.Arman@ki.se
Kontaktpersoner :
Title : Causal Inference for Epidemiological Research
Kursnummer : 2416
Datum : 20151130 20151204
Språk : Engelska
Särskild behörighet : The students are expected to have taken Epidemiology I, Epidemiology II,
Biostatistics I, and Biostatistics II. Exceptions can be made if the students have taken other courses with an
equivalent content.
Kursens lärandemål : After the course the student will be able to use counterfactuals to express and
interpret causal queries be able to judge when standard statistical methodology is appropriate for causal
inference, and when it is not be able to use Directed Acyclic Graphs to describe and analyze complex
epidemiological scenarios be able to use Marginal Structural Models to analyze longitudinal data, with
additional help from a skilled statistician Kursens innehåll : Causal inference from observational data is a key task of biostatistics and of allied
sciences such as sociology, education, behavioral sciences, demography, economics, health services
research, etc. These disciplines share a methodological framework for causal inference that has been
developed over the last decades. This course presents this unifying causal theory and shows how
biostatistical concepts and methods can be understood within this general framework. The course
emphasizes conceptualization but also introduces statistical models and methods for timevarying
exposures. Specifically, this course strives to a) formally define causal concepts such as causal effect and
confounding, b) identify the conditions required to estimate causal effects, and c) use analytical methods
that, under those conditions, provide estimates that can be endowed with a causal interpretation. The
(causal) methods can be used under less restrictive conditions than the traditional statistical methods. For
example, causal methods allow one to estimate the causal effect of a timevarying exposure in the presence
of timedependent confounders that lie on the causal pathway between exposure and outcome.
Arbetsformer : Lectures and group discussions.
Examination : There will be a takehome exam handed out at the last day of the course. Students who fail
will be given the opportunity to write at a maximum 2 reexams. Dates for the reexams will be announced
later.
Urval av studenter : Eligible doctoral students will be prioritized according to 1) the relevance of the
course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration
as a doctoral student (priority given to earlier registration date). To be considered, submit a completed
application form. Give all information requested, including a short description of current research and
motivation for attending, as well as an account of previous courses taken. Övrig information : Prerequisite knowledge equivalent to "Epidemiology I: Introduction to epidemiology",
"Epidemiology II: Design of epidemiological studies", "Biostatistics I: Introduction for epidemiologists" and
"Biostatistics II: Logistic regression for epidemiologists" or courses with corresponding learning outcomes
Kursansvarig : Yudi Pawitan
Yudi.Pawitan@ki.se
08524 822 93
Title : Methods in molecular biology and their applications in
medical research
Kursnummer : 2418
Datum : 20150907 20150918
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course, the students will understand the principles, from both a
theoretical and practical viewpoint, of a number of basic techniques used in DNA/protein research and their
application in medical research. The students should also be able to design and perform investigations with
some of the discussed techniques.
Kursens innehåll : The aim of this course is to confer knowledge of how basic molecular biology and
protein work can be applied in clinically oriented research work. The course is designed for graduate
students with limited experience of molecular biology and combines a lecture program with laboratory work.
The lectures will include theoretical and practical aspects on basic concepts concerning techniques in
molecular biology and proteomics and their application in medical research. Specified subjects will include
cloning, RNAanalysis, promoter studies, DNAsequencing, expression, bioinformatics, antibody based
protein detection and proteomics. The overall objective is to convey knowledge of possibilities and
limitations with different techniques and introduce valuable methodology for the students PhDprojects. Arbetsformer : The course combines a lecture program in the morning with laboratory work in the
afternoon, where course participants will be subdivided into smaller groups.
Examination : The students will be asked to solve a scientific problem using methods they learned during
the course. The last day of the course, the participants will give a presentation. They should be able to
defend the laboratory design, discuss methodologies applied and anticipated results. The students will work
in pairs. The task will be given to the participants at the end of the first week.
Obligatoriska moment : Laboratory work is compulsory. To compensate for absence, selfstudies and an
written essay on the topic(s) that they have missed must be performed.
Övrig information : The course combines a lecture program in the morning with laboratory work in the
afternoon, where course participants will be subdivided into smaller groups.
Kursansvarig : Agne Kulyte
Agne.Kulyte@ki.se
Kontaktpersoner : Camilla Pramfalk
Camilla.Pramfalk@ki.se
Title : Principles of nucleic acid structure
Kursnummer : 2430
Datum : 20151116 20151204
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course, the participants will be able: to describe and to visualize nucleic
acid structures. to apply principles regulating nucleic acid structures. to explain the relation between
structure and function in nucleic acid molecules to evaluate critically experiments used to provide RNA or
DNA structural information. Kursens innehåll : A general introduction to nucleic acids nomenclature. Structural and conformational
features of nucleotides. Physical properties. Hydrogen bonding and base stacking. Water and nucleic acid.
Metal ion and nucleic acid. Secondary and tertiary structures of DNA and RNA. Methods to determine
structures and dynamics of DNA and RNA systems (such as xray crystallography, NMR, theoretical
approaches and so on) General consideration on proteinnucleic acid interactions, DNA superhelix, higher
order nucleic acid structure. Small introduction to secondary structure predictions, structural database,
molecular visualization. Three invited lectures on specific topic.
Arbetsformer : The course consist in lectures, seminars, short presentations given by the participants.
group activities under the supervision of the course leader, computer tutorials on database and molecular
visualization (14 meetings of three hours each) During the course period, the participants will work
individually on an written assessment portfolio, give and receive feedback on the written work. In addition,
the participants will prepare and discuss a seminar on an assigned topic. The participants should integrate
each lectures hour with homework and reading. Examination : A final written exam will be used to assess the participant's ability to describe and apply the
structural principles of nucleic acid structures. The seminar and written assessment portfolio will be used to
assess the participant's ability to explain the relation between structure and function in nucleic acid
molecules and to evaluate critically experiments used to provide RNA or DNA structural information. Obligatoriska moment : The participant must participate actively by attending the lectures and the
seminars, by completing the assigned tasks. In addition, the participant must complete the assessment
portfolio and final exam. Absence to a lecture will be compensated with extra assignments. The students
will get some key questions on the corresponding lecture, and the answers should be submit in written form
for review and approval. Antal studenter : 8 20
Övrig information : The course is held at Huddinge Campus. The meetings will be held from 9 to 16
during all the day of week 47, and Thursday and Friday of weeks 48 and 49. A minisymposium will be held
on Friday 27th November with national and international experts (see
http://www.biosci.ki.se/users/villa/teach.htm for the speakers in the previous occasions). The course is
held every 1.52 years
Kursansvarig : Alessandra Villa
+4686089195
Alessandra.Villa@ki.se
Hälsovägen 7
NOVUM
141 83
Huddingen
Kontaktpersoner :
Title : Clinical Research in Lipid Metabolism
Kursnummer : 2433
Datum : 20151019 20151023
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course the students will be able to: 1. Describe lipid and lipoprotein
metabolism 2. Understand how to analyze fatty acids, and sterols (by SEC, HPLC and gaschromatography
mass spectrometry) 3. Understand principles for subcellular fractionation, enzyme and receptor assays, and
molecular biology of proteins in lipid metabolism 4. Describe genetic hyperlipoproteinemias 5. Understand
which techniques that can be used in in vivo studies, such as biopsy techniques, microdialysis, and in
turnover studies of lipid and lipoprotein metabolism
Kursens innehåll : Overview and new developments within the field of clinical research in lipid
metabolism. Emphasis will be laid on cholesterol metabolism, lipoproteins, lipoprotein receptors and on the
regulation of enzymes involved in biosynthesis and metabolism of cholesterol, bile acids, fatty acids and
triglycerides. Genetic diseases and effects of diet on clinical conditions such as atherosclerosis, obesity,
diabetes, and gallstone disease will also be highlighted. Arbetsformer : Lectures (24). The participants will also be invited to present their own projects for general
discussion on the methodological aspects of their project. Examination : In order to evaluate the students knowledge regarding clinical research in lipid metabolism
a written examination consisting of short answer questions and multiple choice questions will be given. Obligatoriska moment : The lectures are not mandatory. However all information presented at the
lectures is compulsory and will be a significant basis for the written examination. Antal studenter : 10 30
Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant¿s
doctoral project (according to written motivation) and 2) date for registration as a doctoral student (priority
given to earlier registration date).
Övrig information : The course is held in English and lectures and self studies will correspond to 40
working hours (1.5 ECTS credits). The location is the Red Seminar Room at Novum, Karolinska Institutet,
Huddinge
Kursansvarig : Mats Rudling
Mats.Rudling@ki.se
Kontaktpersoner : Sara Straniero
sara.straniero@ki.se
Ylva Bonde
Ylva.Bonde@ki.se
Lena Emtestam
Lena.Emtestam@ki.se
Title : Public health intervention and implementation research
Kursnummer : 2454
Datum : 20151019 20151120
Språk : Engelska
Särskild behörighet : Kursens lärandemål : At the end of the course the student should be able to: 1. Define core concepts in
intervention and implementation research 2. Understand the concept of evidencebased public health 3.
Understand how to critically appraise published intervention and implementation studies, as well as
systematic reviews in public health 4. Describe models and frameworks of intervention and implementation
research 5. Design an intervention study, which includes a relevant problem theory and a programme
theory, appraisal of ethical aspects as well as evaluation design 6. Design the implementation of an
evidencebased programme or practice, and describe the evaluation design 7. Understand concepts of
fidelity and adaptation Kursens innehåll : As this course aims at giving doctoral students knowledge in theory, method and
practice in the field of public health intervention and implementation research, the content focuses on the
following themes: 1. Models and frameworks in intervention and implementation research 2. How to apply a
theoretical perspective using relevant change theories 3. Intervention and implementation core
components, barriers and facilitators 4. Appropriate study designs for process and outcome evaluation 5.
Systematic and critical appraisal of published intervention and implementation studies 6. Dissemination of
scientific results Arbetsformer : The course is based on lectures in combination with seminars in order to promote a
reflective, analytical and critical approach towards this research field. The course will also use group
assignments and group discussions to promote the students active participation in their learning process, as
well as the ability to accomplish tasks both individually and in groups. All teaching activities aim at
enhancing the student's ability to apply for example core concepts and theoretical frameworks, not the least
ethical aspects, in an analytical and reflective practice and to apply this on the students own research
projects. All teachers in the course are active researchers in the field of intervention and implementation
research. Examination : The students' knowledge and skills in theory, method and practice in the field of public
health interventions and implementation research will be assessed in relation to the expected learning
outcomes through the following examinations: a. Formative assessment during active participation in
seminars with presentations, in discussions and short seminar reports b. Summative assessment of a
written project report, oral presentation of the report and opposition Obligatoriska moment : Participation in scheduled seminars and group work and examination is
compulsory. Absence is compensated through a written summary of the literature for the seminar where
the absence occurred. Antal studenter : 12 20
Urval av studenter : Selection will be based on the relevance of the course syllabus for the applicant's
doctoral project (according to written motivation)
Övrig information : Classroom meetings are scheduled on Mondays and Tuesdays. All teachers involved in
the course are active researchers in the field of intervention and implementation research.
Kursansvarig : Lydia Kwak
Lydia.Kwak@ki.se
Nobels väg 13
17177
Stockholm
Title : Thrombosis and Hemostasis, from mechanisms to
therapies
Kursnummer : 2484
Datum : 20151102 20151106
Språk : Engelska
Särskild behörighet : Kursens lärandemål : The concept from bench to bed side and back will be reinforced at all levels.
Therefore, at the end of the course the students should be able to: 1. Describe the molecular and cellular
mechanisms of haemostasis and thrombosis, as well as the dynamic processes of primary haemostasis,
secondary haemostasis, and thrombosis. 2. Explain the mechanisms underlying bleeding and thrombotic
disorders. 3. Have a good understanding of current anticoagulant and antiplatelet therapies, and obtain a
clear view of the challenges of future anticoagulant and antiplatelet drug developments. 4. Apply current
knowledge of thrombosis and haemostasis into future research design and to formulate new treatment
strategies. 5. Sharpen the sense of critical appreciation of research literature, and strengthen their ability to
develop new research concepts through critical reading. Kursens innehåll : The course aims to bring in indepth knowledge of thrombosis and hemostasis, and to
emphasize a translational view, from bench to bed side and back, of the hemostatic system to the students.
The course is designed for the students who work in both basic and clinical aspects of hemostasis,
thrombosis and cardiovascular research. The following aspects of hemostasis and thrombosis will be
discussed: biochemistry of the blood clotting system; cellcell and cellprotein interactions in the
cardiovascular system in relation to thrombosis and bleeding disorders; crosstalks of the clotting system
with inflammation, host defense and complement systems; diagnosis of bleeding and thrombotic disorders;
therapeutic strategies to fight thrombosis and bleeding with the emphasis placed on new pharmacological
concepts.
Arbetsformer : Lectures Seminars Group work Presentation of papers related to the key lectures Examination : Presentation of a paper related to key lectures Short written homework. Multiplechoice
test. Obligatoriska moment : To participate in the lectures, group work and presentation of the group work is
compulsory. The students who have missed the group work sessions can book extra session time within 4
weeks to compensate the absence. Absence in lectures should be compensated for in accordance with the
course director.
Urval av studenter : In case the course receives more applications than the maximal course slots.
Selection of the participants is thus needed and made according to: 1) the relevance of the course syllabus
for the applicant's doctoral project (according to written motivation), 2) KI doctoral students prior to
doctoral students from partner universities; 3) date for registration as a doctoral student (priority given to
earlier registration date)
Övrig information : Course will be held during week 45 (Monday Friday; 9:0016:30). Lecture hall
booked: CMM lecture hall, L8:00 at Karolinska University HospitalSolna. Lectures will be given by 14
lecturers who are all wellestablished experts on their lecture subjects. The course has been given at KI
over 20 years with about 10 course occasions. The course is well received by the course participants over
the years. The course in HT 2014 was highly remarked in the course evaluation (linked).
Kursansvarig : Nailin Li
0851773996
Nailin.Li@ki.se
17176
Stockholm
Kontaktpersoner : Angela Silveira
0851773224
Angela.Silveira@ki.se
Title : Obesity basic science, clinical and epidemiological
aspects
Kursnummer : 2498
Datum : 20151116 20151120
Språk : Engelska
Kursansvarig institution : Department of Public Health Sciences
Särskild behörighet : Kursens lärandemål : At the end of the course the students should be able to: 1, Discuss different
hypothesis and theories concerning the pathogenesis of obesity 2, Discuss occurence of obesity and co
morbid diseases in society 3, Discuss current treatment methods of obesity and effects of these treatments
on comorbid diseases 4, Discuss methods to prevent obesity and methods used to evaluate effects of
treatment and prevention 5, To relate clinical and public health aspects of obesity to research aspects of
obesity Kursens innehåll : The course is to give an overview of obesity in society, pathogenesis and current
treatment methods. These clinical examples will be used to demonstrate how one can design various
research projects related to obesity and comorbid disease preclinical, clinical, epidemiologcal and
preventive projects.
Arbetsformer : The course will be based on lectures, work in small seminar groups and demonstration of
surgery of obesity.
Examination : Written examination
Obligatoriska moment : Presence at lectures, group work and demonstration is mandatory. Absence must
be compensated by a written task.
Övrig information : The course will take place at Danderyd University Hospital. Kursansvarig : Erik Näslund
Institutionen för kliniska vetenskaper, Danderyds sjukhus
086555017
Erik.Naslund@ki.se
Kontaktpersoner :
Title : Cancer cell energy metabolism
Kursnummer : 2515
Datum : 20151102 20151106
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course, the student should be able to: describe and explain the role of
altered cellular metabolism in cancer development and cancer progression; reflect upon the interaction
between oncogenic signaling and tumor metabolism; discuss how tumor metabolism may be exploited in
anticancer therapies and diagnosis/prognosis. Kursens innehåll : The course provides an introduction to cancer cell metabolism. Focus is on the roles of
oncogenic signaling and tumor microenvironment as drivers of tumor development and progression.
Therapeutic and diagnostic perspectives exploiting the altered cancer metabolism are discussed.
Arbetsformer : The course consists mainly of lectures, but also a minisymposium with invited international
speakers and group discussions/seminars.
Examination : Examination is divided into two parts: Firstly, during active participation in the Meet the
scientists seminar and in connection with the beehive group preparing that. Secondly, the students will be
given an individual written assignment to be delivered within two weeks after the end of the course. This
assignment is a short project proposal within one topic chosen from a list of 10. The proposal will contain an
overview of the field which motivates a specific research question identified by the student and a brief work
plan that explains how the question/hypothesis can be solved/investigated. Obligatoriska moment : Attendance at lectures is strongly advised. Participation in the beehive and Meet
the scientist session is mandatory. To compensate for absence due to e.g. illness the student may be
required to write a report and/or discuss the missed subject with the course leaders.
Övrig information : Kursansvarig : Angelo De Milito
0851771766
Angelo.DeMilito@ki.se
Forskningsringen 50
17462
Sundbyberg
Kontaktpersoner : Mimmi Shoshan
08517 754 60
Mimmi.Shoshan@ki.se
Title : Basics of Qualitative research
Kursnummer : 2518
Datum : 20150914 20150918
Språk : Engelska
Kursansvarig institution : Department of Clinical Science and Education, Södersjukhuset
Särskild behörighet : Kursens lärandemål : At the end of the course the participants will be able: 1. To describe different
theoretical starting points for qualitative inquiry 2. To apply knowledge of qualitative research methods for
discussing rationales for the design of the qualitative inquiry 3. To critically compare of qualitative and
quantitative research (basic assumptions of the qualitative research paradigm as it compares to the
quantitative paradigm) 4. To describe the common essential elements of qualitative research including How
to select the appropriate: qualitative research methods based on phenomenon of interest setting for data
collection,study participants, data generation strategies (including individual interviews, focus group
discussion, written narratives, participants observation and field notes)and data analysis method 5. To
critically comments on/evaluate the weaknesses and strengths of the studies(published papers) using
qualitative research in terms of research question, aim and method 6. To design a qualitative research
proposal in the field of health Kursens innehåll : The course will provide some of the most important information which students need to
understand and implement successful qualitative research methods (including the common essential
elements of qualitative research). In addition the course will provide step by step guidance to examine and
apply current qualitative methodologies as a way to generate, manage, analysis qualitative data and
moreover ,ethical considerations. The course will starts with the definition of qualitative research, basic
assumptions and characteristics of qualitative research in comparison to quantitative research. Following
that will be the notion of some common essential elements in qualitative methods such as: selecting the
methods based on phenomenon of interest, using the literature review, choosing the setting for data
collection, selecting participants, generating data and content analysis .After that , practical principle to do
qualitative inquiry will be addressed. Finally ethical considerations in qualitative research will be explained.
Arbetsformer : The learning activities on the course are a mix of lectures, discussions, individual and
group; interview, seminar, field observation and individual presentations.
Examination : The course assessment will include formative and summative assessments. The formative
assessment (50%) will be made through Peer learning Activity, critic a qualitative paper, individual and
group presentation, while summative assessment (50%) will be through a written examination and
individual qualitative proposal. In this way, the students are examined with both groupwise and individual
presentations.
Obligatoriska moment : Active participation in the class discussions, individual and group assignment
(individual and group interview and field observation), written assignment (an abstract of a qualitative
proposal) and student presentations is mandatory. Compensation according to the instructions of the course
director, which means absence in less than 2 lectures is acceptable and should be compensated by an
individual project related to that particular session.
Övrig information : Kursansvarig : Hamid Khankeh
Institutionen för klinisk forskning och utbildning, Södersjukhuset
hamid.khankeh@ki.se
Sjukhusbacken 10
118 83 Stockholm
Kontaktpersoner : Jeanette Brynholt Ohrman
086162935
jeanette.brynholt.ohrman@ki.se
Title : Cellular Reprogramming from basal mechanisms to
medical applications
Kursnummer : 2525
Datum : 20150914 20150918
Språk : Engelska
Särskild behörighet : Kursens lärandemål : Upon completion of the course, the doctoral student will be familiar with
mechanisms of nuclear reprogramming and how reprogramming techniques can be utilized in various
research areas. Emphasis will be put on providing the student with knowledge to critically read and evaluate
research work in the reprogramming field, as well as on how appropriate reprogramming methods and
procedures can be applied in various research projects.
Kursens innehåll : The course is composed of lectures that address different aspects of cellular
reprogramming, i.e. how cellular identity can be changed, covering both basic scientific mechanisms as well
as experimental procedures of cellular reprogramming. The primary focus will be on the reprogramming of
fully differentiated cells to induced pluripotent stem (iPS) cells, but direct reprogramming from one
differentiated state to another will be discussed as well. Controlled differentiation of pluripotent cells to
specific fates and the use of cellular reprogramming in disease modeling will be discussed.
Arbetsformer : The learning activities are a mixture of lectures, discussions, group seminars and individual
presentations.
Examination : The students are examined with individual presentations.
Obligatoriska moment : Participation in the group discussions and student presentations is mandatory.
Compensation is according to the instructions of the course director.
Övrig information : The course is organized by the Research School of the Linné Center DBRM
(Developmental Biology for Regegerative Medicine). More course information can be found at the Research
School web pages at www.dbrm.se. The course is full time, given in English, and the course venue is the
seminar room A216 at CMB, Berzeliusv 35.
Matti.Nikkola@ki.se
Kontaktpersoner :
Title : Neuropschopharmacology
Kursnummer : 2526
Datum : 20151123 20151201
Språk : Engelska
Särskild behörighet : Kursens lärandemål : By the end of this course the PhD students should: 1) have achieved an
understanding of the etiology of psychiatric disorders and are able to account for different hypotheses in
this field and how the major psychiatric diseases are treated. 2) possess skills in handling methods and
animal models for studying the effects of drugs on different symptoms of psychiatric diseases. 3) be able to
evaluate data and preclinical research within the research fields of psychiatric diseases. Kursens innehåll : This course will focus on pharmacological strategies in the treatment of psychiatric
disorders, e.g. schizophrenia, major depression etc. The course will also discuss methods and models which
are used in preclinical research concerning the mechanisms of action of different drugs in the treatment of
these disorders. Arbetsformer : The pedagogic framing of the course include lectures given by invited clinicians and
researchers within the field of psychiatric disorders. We will also have demonstrations of key
models/methods which are used in specific research projects.
Examination : Written exam Obligatoriska moment : The demonstrations are mandatory. The student has to compensate absense
from this part with a written description of the model/method.
Övrig information : Kursansvarig : Kent Jardemark
Institutionen för Fysiologi och Farmakologi
0852487918
Kent.Jardemark@ki.se
Kontaktpersoner : Vasco Sousa
vasco.sousa@ki.se
Title : The major global infectious diseases: tuberculosis and
HIV
Kursnummer : 2536
Datum : 20151123 20151127
Språk : Engelska
Särskild behörighet : Kursens lärandemål : At the end of the course the students should be able to: describe the disease
mechanisms of TB and HIV infection and discuss important differences and similarities between these
infections and their impact on global health. explain the challenges regarding clinical symptoms,
diagnosis, treatment and drugresistance, vaccine strategies and TB/HIV coinfection. analyse how clinical
management of TB and HIV can be integrated and linked to molecular knowledge as well as public health
issues. discuss and critically evaluate current issues in TB and HIV research including prevention and
control in low, middle and high income countries. Kursens innehåll : An overview of tuberculosis (TB) and HIV/AIDS infection and disease including relevant
virology and bacteriology, TB/HIV coinfection, clinical management, international public health aspects,
immunology and pathogenesis, diagnostic methods and principles of vaccines, therapy and drug resistance
as well as novel research strategies.
Arbetsformer : The course will consist of a mixture of lectures by invited speakers, seminars and practical
sessions i.e. study questions and group assignments. The students will have access to computer rooms.
Examination : Study questions and group assignment will be presented (both orally and in written) and
discussed by the students and facilitators on a daily basis. Thus, the individual learning outcome will be
assessed on a daily basis. Furthermore, on the last day of the course, concept maps will be used to
summarize individual learning outcome.
Obligatoriska moment : It is compulsory to attend all the lectures and sessions, including the group
assignment. Absence has to be compensated by an individual written assignment provided by the course
leader.
Övrig information : The course will take place at Karolinska Universityhospital Solna, at the Center for
Molecular Medicine (CMM), MondayFriday 08.3016.30. We plan to invite several speakers from TB/HIV
high endemic countries to talk about reallife experiences
Kursansvarig : Annelie Tjernlund
Annelie.Tjernlund@ki.se
Jordgränd 44
192 74
Sollentuna
Kontaktpersoner : Anne Rasikari
08517 718 61
Anne.Rasikari@ki.se
B3:03
Title : Writing Science and Information Literacy
Kursnummer : 2561
Datum : 20150824 20151016
Språk : Engelska
Särskild behörighet : Kursens lärandemål : Demonstrate understanding of how to write an original scientific article and submit
it for publication Demonstrate ability to write other types of texts required for a scientific career Demonstrate ability to give, take, and make use of constructive criticism Demonstrate the ability to search
and manage the medical sciences literature in a structured way Demonstrate the ability to use resources
which facilitate choosing a journal to publish your research Describe aspects of postpublication evaluation
and processing of the medical sciences literature
Kursens innehåll : Basic of scientific writing Writing an original scientific paper Supporting the text Writing
in other contexts The publication process Searching the literature Managing the literature Choosing a
journal Evaluating published science KIpostpublication processing Arbetsformer : This webbased course will be held using the learning management system PingPong.
Content will be learnt with various learning objects and learning practised by exercises. Formative feedback
will be given by teachers/peer/selfassessment. Writing and IT skills will be developed.
Examination : The intended learning outcomes are assessed in the summative examination. Participants
will write and rewrite a grant application and popular science summary based on teacher and peer
feedback. Participants will also complete a number of assignments which demonstrate their ability to use a
number of relevant IT resources in a context of scientific communication.
Obligatoriska moment : There will be a number of obligatory tests and assignments to be completed.
Övrig information : This is an entirely webbased course with teacher support but no physical meetings.
The course is read at 25% of fulltime.
Kursansvarig : David Herron
08524 841 13
David.Herron@ki.se
Berzelius 7B
17177
Stockholm
Kontaktpersoner :
Title : Introduction to R statistical analysis for biologists
Kursnummer : 2570
Datum : 20151109 20151113
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the completion of the course, the participants will be able to make use of R
for exploring and analyzing data sets. More specifically, the participants will be able to manage data sets,
perform descriptive data analysis, generate plots for graphical display of data, and to perform tests such as
Regression and ANOVA. A very specific goal is to provide the participants with a longterm tool and the
guidelines for improving their knowledge on it. Kursens innehåll : Data sets and formats in R. Descriptive statistics. Graphical display of data. Classical
tests. Regression, ANOVA, KruskalWallis. Experimental design. Graphical display of analysis. Use of
documentation in R. Arbetsformer : The course consists of lectures, computer excercises and project work.
Examination : The acquired knowledge and skills will be examined in two ways: by successfully completing
computer exercises and by a individual project (analysis of a selected data set; which can be provided by
the student).
Obligatoriska moment : Attendance is compulsory in lectures and computer excercises. Absence from
obligatory moments is compensated according to the instructions of the course director.
Urval av studenter : Selection is based on the relevance of the course content for the doctoral project, the
personal motivation included in the course application and the date for registration as a doctoral student
(priority given to earlier registration date).
Övrig information : The course takes place at CMB at KI Solna campus, in the seminar room A216.
Entrance Berzeliusv 35. The course director is Dr. David GomezCabrero at the Department of Medicine,
Solna. Email david.gomezcabrero@ki.se.
Matti.Nikkola@ki.se
Kontaktpersoner :
Title : Noncoding RNA and cancer
Kursnummer : 2583
Datum : 20151130 20151204
Språk : Engelska
Särskild behörighet : Kursens lärandemål : At the end of the course, the students are expected to be able to: understand the
diversity of noncoding RNAs and their importance in tumorigenesis and tumor progression. describe
various methodologies for noncoding RNA research, account for applications and apply relevant approaches
in their own projects.
Kursens innehåll : Noncoding RNAs are key regulators of gene expression with important impact in many
biological processes. Recent research has identified different classes of noncoding RNA and their roles in
cancer development and progression. Through short introductory lectures and indepth discussion of key
papers from the recent literature, this course will cover an uptodate introduction to the biogenesis of
diverse noncoding RNAs (including small RNAs and long noncoding intergenic RNAs) and their
mechanisms of gene regulation, methodologies for noncoding RNA research, expression and function of
noncoding RNAs in cancer development, and their potential clinical implications.
Arbetsformer : The course consists of lectures and problembased discussions. In addition, the students
are required to submit a research proposal on a topic related to noncoding RNA and cancer.
Examination : The examination of the course includes problembased discussions, and reviewing and
presenting individual research proposal related to noncoding RNA. Obligatoriska moment : The students are expected to attend all lectures and problembased discussions,
as well as to complete all assignments. In the case of absence, the student will be asked to compensate by
completing another written assignment given by the course organizer. Antal studenter : 12 20
Urval av studenter : Selection will be based on the relevance of the course to the student's research
project and the personal motivation for participation in this course.
Övrig information : This fulltime course will be held at Cancer Center Karolinska, Karolinska University
HospitalSolna. Kursansvarig : Wengonn Lui
0851773930
Wengonn.Lui@ki.se
Kontaktpersoner :
Title : Neurogenetics
Kursnummer : 2600
Datum : 20150928 20151002
Språk : Engelska
Särskild behörighet : Kursens lärandemål : I) The student will be able to understand and describe the major differences and
uses of human genetic studies of neurogenetic diseases using i) Twinstudies, ii) population based studies,
iii) casecontrol studies, iv) family studies. Students will have an in depth knowledge and understanding of
selected neurologic conditions such as Alzheimer disease, trinucleotide repeat disorders, their genetic basis
and an insight into the molecular pathogenesis, if known. II) The students will also be able to describe how
genetic studies can be used to increase our understanding of the biological basis of neurological conditions.
III) The students will be able to contribute substantially to critical evaluation and presentation of scientific
articles in the field of neurogenetics. IV) The students will have an understanding of the different genetic
techniques and platforms available for studies in human (neurological) conditions.V) The students will have
an insight in the application/use of genetic testing for neurological diseases.
Kursens innehåll : I) The course will give examples of how different types of genetic studies can help us
identify genes involced in the pathogenesis of neurological disease: i) Twinstudies, ii) population based
studies, iii) casecontrol studies, iv) family studies. II) The course will give examples of different gene
defects in neurological diseases such as trinucleotide repeats, point mutations, copy number variations,
susceptibility genes, rearrangements, transciptional regulation and epigenetics. III) The course will provide
an in depth understanding of the genetics of selected neurological diseases and how these genetic
dysfunctions help us understand the molecular mechanisms of disease.
Arbetsformer : Daily classroom lectures. The last session on Monday through Thursday will be in a
workshop/seminar format where the students prepare a group presentation of a selected topic/genetic
neurological disease. The presentation will be on the last day of the course and consitutes the examination.
Examination : The examination will be on the last day of the course and it will consist of i) participating in
a group presentation of a selected topic/genetic neurological disease ii) participate as an active audience
when other groups have their presentations. Every student will be assessed individually in accordance with
the intended learning outcomes of the course.
Obligatoriska moment : All lectures/seminars are compulsory and in case of absence, the session can be
compensated by a short written report using the literature after agreement with the course director.
Urval av studenter : Selection will be based on 1) the applicant's written motivation 2) the date of
admission to doctoral education. Övrig information : The course is part if the Frontiers Courses in Neuroscience and the course participants
will be a mix of master students and PhDstudents. This is a fulltime course (9:0017:00) and will be held
at the Karolinska Institutet. Details about specific lecturehalls and seminar rooms will be provided in
August 2015. Kursansvarig : Caroline Graff
0858583619
Caroline.Graff@ki.se
KIADRC, Novum plan 5
141 86
Stockholm
Kontaktpersoner : Annica Rönnbäck
annica.ronnback@ki.se
Title : Brain development and Neurodevelopmental disorders
Kursnummer : 2605
Datum : 20150921 20150925
Språk : Engelska
Kursansvarig institution : Department of Neuroscience
Särskild behörighet : Background in medicine, biomedicine, neuroscience or psychology.
Kursens lärandemål : The aim of this translational neuroscience course is to provide an overview on the
emerging field of developmental cognitive neuroscience. In particular, we will focus on cortical brain
development, development of cognitive functions in typically developing children and children with
neurodevelopmental disorders e.g., AttentionDeficit /Hyperactivity Disorder (ADHD) and Autism Spectrum
Disorders (ASD), and the role of both genetic and environmental factors in the etiology of these disorders.
During the course, students will learn to critically evaluate and explain in presentations the content of
original articles. After the course students should be able to: 1) Describe fundamental
neurodevelopmental processes (e.g. neurogenesis, neuronal migration, synaptogenesis). 2) Describe
genetic and molecular mechanisms controlling cortical development. 3) Describe cognitive deficits among
neurodevelopmental disorders (e.g., ADHD and ASD). 4) Postulate potential genetic /molecular
mechanisms underlying cognitive deficits in children with neurodevelopmental disorders Kursens innehåll : Course Curriculum Part I: Fundamentals of Developmental Neurobiology 1. Early
brain development, construction of neural circuits, and modification of neural circuits as a result of
experience 2. Genetic control of cortical development 3. Effects of sex hormones on brain development Part II: Functional Brain development in humans 1. AgeRelated Changes in executive function (e.g.,
working memory) 2. Working memory, and training induced plasticity 3. The molecular genetics of
executive function Part III: Neurodevelopmental Aspects of Clinical Disorders 1. The neurobiology and
genetics of ADHD 2. Advances in the Cognitive Neuroscience of ASD 3. Childhood psychiatric disorders as
anomalies in neurodevelopmental trajectories Arbetsformer : A variety of teaching and learning strategies are presented during the course to facilitate
students learning. These strategies include short lectures, small group discussions, computerbased
learning, and problem based learning.
Examination : The examination will consist of an oral group presentation focusing on cognitive deficits
found in children with neurodevelopmental disorders (e.g. ADHD and ASD) and the potential genetic /
molecular mechanisms underlying these deficits. At the beginning of the course, students will be assigned
into different working group themes e.g., ADHD and ASD. These groups will work together throughout the
course and prepare for the final oral presentation. During the course there will also be formative
assessments to give students immediate feedback about their learning process during the different
milestones of the course and clarify any questions relating to the final assessment. Course grades Pass:
Students demonstrate an understanding of brain development and cognitive deficits found in neuro
developmental disorders, and can postulate/hypothesize potential genetic / molecular mechanisms
underlying these deficits based upon findings from both basic and clinical literature.
Obligatoriska moment : All lectures and seminars are mandatory. In order to make up for absence of a
particular lecture, the students will be required to read specific chapters from the recommended literature
and write a short report.
Övrig information : We are very honored to have Professor Pasko Rakic from Yale University School of
Medicine as our keynote speaker and other top international speakers, including Professor Derrick MacFabe
from the University of Western Ontario. The course will take place at KI Solna campus (Monday through
Friday between 09:0016:30). Note: The title of the course will change to "Neurodevelopmental
Disorders: From basic research to the clinic".
Kursansvarig : Rochellys Heijtz
0852487886
Rochellys.Heijtz@ki.se
Retzius Väg 8
17177
Stockholm
Kontaktpersoner :
Title : Mechanisms of Gene Regulation in Metabolism
Kursnummer : 2608
Datum : 20151105 20151111
Språk : Engelska
Kursansvarig institution : Department of Physiology and Pharmacology
Särskild behörighet : Kursens lärandemål : At the end of the course students will understand and be able to discuss the
different mechanisms that regulate gene expression. They will be able to describe how these processes can
affect metabolic disease and disease progression. The students will be able to choose the most appropriate
methodologies to study diverse aspects of gene regulation in metabolism.
Kursens innehåll : This course aims at giving students an overview of the current understanding of how
metabolism and metabolic dysfunction are controlled at the level of gene regulation. During one week,
students will focus on the genetic and epigenetic mechanisms that affect transcriptional output in diverse
organs and tissues in health and disease situations. This will include: basic mechanisms of gene
transcription, transcription factors and coregulators, mRNA splicing and genetic variability, the chromatin
landscape and associated DNA and histone modifications, noncoding RNAs and regulation of gene
expression. Attention will be given to single gene analysis as well as global regulation of gene expression.
In each module the student will be introduced to the basic concepts in the field and analyze situations in
which dysregulation of the processes under examination leads to metabolic disease. Each module will
include a chapter dedicated to the presentation and discussion of current experimental approaches relevant
to research in that particular field of science.
Arbetsformer : This course will consist mainly of lectures and group discussions covering both theoretical
and practical questions related to the different areas of gene regulation and metabolism. Some sessions will
be dedicated to problem solving and presentation of stateoftheart methodologies relevant to research in
each field.
Examination : Examination will consist of an oral presentation in which students discuss an example of
metabolic disorder caused by dysregulation of gene expression and propose a research plan to further study
that problem. The research plan should include appropriate methodology learned during the course.
Obligatoriska moment : Presence at lectures, group work, and final presentation and discussion is
mandatory. To compensate for absence a written essay on the missed topic must be performed.
Övrig information : The course duration is 5 weekdays and it's divided in two blocks. The first block (Nov
5 6) addresses more general knowledge in mechanisms of gene regulation with focus on metabolism, and
the second (Nov 9 11), the more specialised course content. We always have an invited lecturer who will
be announced closer to the date since we are still awaiting confirmation.
Kursansvarig : Jorge Ruas
(08)52487261
Jorge.Ruas@ki.se
von Eulers väg 8
17177
Stockholm
Kontaktpersoner :
Title : Basic Course in Medical Statistics a distance course
Kursnummer : 2609
Datum : 20150921 20151002
Språk : Engelska
Särskild behörighet : Kursens lärandemål : The course participants shall after the course be able to perform basic summaries,
analyses and presentation of data, as well as have enhanced their ability to recognise, understand and
critically view the statistics being presented in medical articles.
Kursens innehåll : The course is an introduction to basic statistical principles and how statistics play a part
in medical research. Concepts being treated are hypothesis, type I error, type II error, estimates,
measurement of dispersion, regression analysis, inference making and how to present the results.
Arbetsformer : The course will be a distance course by using the platform edX. The course contains
videolectures, exercises with suggested solutions and 2 statistical software demonstration videos
Statistica and SPSS. The first and last day of the course will be facetoface with an introduction the first
day and seminars and group discussions the last day. In addition to the different videomoments the time
will be spent working on computer based exercises and reading the course literature. Examination : Course requirements: Correct answers on the computer based exercises. The doctoral
student will during the seminars have to demonstrate their ability to recognise, understand and criticize the
statistics presented in the medical articles by active participation in the discussions. Obligatoriska moment : Attendance is mandatory for the seminars on the last day of the course. If the
student is absent, he or she can compensate the absence by handing in written answers to questions
concerning the compulsory moments.
Urval av studenter : Date for registration as a doctoral student (priority given to earlier registration date).
Please make sure that you have entered the correct registration date for doctoral education in your
personal profile.
Övrig information : Kursansvarig : Mesfin Tessma
Mesfin.Tessma@ki.se
52487118
Title : Frontiers in Cogntive Neuroscience
Kursnummer : 2616
Datum : 20150914 20150918
Språk : Engelska
Särskild behörighet : 180 hp in medicine, biomedicine, biology, psychology, or cognitive science, or
master degree in medical imaging engineering
Kursens lärandemål : After the course the student must be able to: (1) account for current concepts and
key principles of cognitive neuroscience; (2) show an understanding of the interdisiplinary nature of
cognitive neuroscience with its roots in both psychology and neuroscience; (3) discuss and critically
evaluate scientific articles in the field; (4) To show basic knowledge about the strengths and weakness of
the different stateoftheart methods used in cognitive neuroscience.
Kursens innehåll : (1) Series of lectures informing about the state of art knowledge about: (i) Perception
and sensory mechanisms; (ii) action planning and execution (iii); (iv) sex differences in the brain; (v)
higher cognitive functions including working memory and creativity; (vi) memory; and (vii) cognitive effects
of aging (2) Seminars where the students will critically discuss key published papers, and group
presentations where they will present their analyses and conclusions for the whole group. Arbetsformer : Lectures, seminars, and group presentations.
Examination : The oral presentation and group discussions during the last day¿s seminar count as
examination. We will assess individual students¿ ability to discuss and reason about current issues and
problems in cognitive neuroscience. Obligatoriska moment : The group seminar is obligatory. In addition to that, the students are assumed to
take part in the lectures. The student will be able to compensate missing attendance by submitting written
reports on the missed material later.
Urval av studenter : Selection will be based on 1) having signed up for the doctoral programme in
Neuroscience or similar field, 2) the relevance of the course syllabus for the applicant's doctoral project
registration date) For more information about the doctoral programmes at KI, see:
https://internwebben.ki.se/en/doctoralprogrammes0
Övrig information : Full day course, Monday to Friday. Kursansvarig : Henrik Ehrsson
0852487231
Henrik.Ehrsson@ki.se
Retzius väg 8
17177 Stockholm
Kontaktpersoner :
Title : Write your research results and get them published
Kursnummer : 2618
Datum : 20151012 20151023
Språk : Engelska
Kursansvarig institution : Department of Women's and children's health
Särskild behörighet : None.
Kursens lärandemål : AFTER ATTENDING THE COURSE, THE PhD STUDENT SHOULD BE ABLE TO:
Explain the characteristics and disposition of different written presentation media and decide which forum is
the most suitable for a specific text Understand, and apply, the terminology associated with scientific
writing Write an abstract Use the correct structure and language to compose a scientific paper and
follow the editorial requirements Revise a manuscript according to a checklist with the most common
lanuage and structure mistakes in scientific writing Use the focus points in a scientific paper (where the
readers focus their reading) Identify the main scope and focus of the research and summarize
information aligned to the target group Apply the structure of popular science writing and use popular
science as a tool for presentations Give a poster presentation Design a scientific poster and reflect
upon structure, language and style Understand the ethics in publication Use the software EndNote for
reference management Search for references in databases (e.g. PubMed) and decide what sources are
reliable Respond to the reviewer´s comments Write a cover letter Reflect on his/her own
development as a writer of different texts during the course Kursens innehåll : THE MAIN SCOPE OF THE COURSE is how to write about research in different contexts
and forums. THE CONTENT OF THE COURSE: Terminology associated to scientific writing Designing
and writing a poster an abstract a draft for a research paper a project plan a reply to the reviewer´s
comments a cover letter a popular science paper The writing process: structure, language, style
Editorial requirements of different journals Summarising and presenting information aiming at the target
audience Identifying the main scope of a research project References and reference management
(EndNote software) Data base search Basic rhetoric for poster presentations References Ethics in
publication Arbetsformer : Lectures, seminares, writing exercises, group assignments and practical exercises. As part
of the learning process, the Ph.D students will be members of inclass review groups, giving feedback to
their colleagues.
Examination : 1) Written assignments reflecting the learning goals of the course: draft for scientific and
popular science paper, poster, electronic poster, and abstract. 2) Evaluation sessions, where the PhD
students give each other feed back on the written assignments as a part of the learning process 3) Poster
presentation, where the PhD students present their posters to another course participant (there are no
presentations in front of a larger group)
Obligatoriska moment : Lectures, workshops, evaluation sessions, and group assignments as well as all
written assignments. Absence can be compensated: a) during next years course b) individual assigments Antal studenter : 18 20
given to LATER registration date)
Övrig information : Welcome to apply for the Ph. D. writing course 2618 on Scientific and popular science
writing! During the course, you will have the opportunity to write a draft for a scientific manuscript, an
abstract, a popular science article, a press release, and to design a poster. The popular science writing is
used as a tool for finding the core of your research project, poster design and presentations. The
course also covers: presentation techniques for presenting your poster at a conference, how to answer the
reviewer's questions, letter to the editor, review article, cover letter, and ethics in publication. New Ph.D.
students are given priority to the course, as we believe that writing is an essential skill that should be
acquired as soon as possible during your time as a doctoral student. However, students who have already
published articles will benefit as much from the course as newly registered students, as you write about
your own research projects, starting on your own level, and in your own pace. The course curriculum takes
into consideration that all students have different background knowledge and are on different stages of
their doctoral education. In order to participate in the course, you need either some preliminary data from
your own research project or other data provided by your supervisor to work with. Our intention is that you
should be able to use everything you write and design during the course: this will keep motivation high and
make sure that you are spending your time in the best possible way. Please address all questions to
Anna Hildenbrand Wachtmeister: anna.wachtmeister@ki.se Cellphone: 0707890607 We are looking
forward to meeting you in the course!
Kursansvarig : Anna Hildenbrand Wachtmeister
Institutionen för kvinnors och barns hälsa
0707890607
Anna.Hildenbrand.Wachtmeister@ki.se
Kontaktpersoner : Anna Hildenbrand Wachtmeister
0707890607
Lalit Kumar
Lalit.Kumar@ki.se
Kursnummer : 2618
Datum : 20150928 20151009
Språk : Engelska
their colleagues.
0707890607
0707890607
Lalit Kumar
Lalit.Kumar@ki.se
Kursnummer : 2618
Datum : 20151116 20151127
Språk : Engelska
their colleagues.
0707890607
0707890607
Lalit Kumar
Lalit.Kumar@ki.se
Kursnummer : 2618
Datum : 20150907 20150918
Språk : Engelska
their colleagues.
0707890607
0707890607
Lalit Kumar
Lalit.Kumar@ki.se
Kursnummer : 2618
Datum : 20151130 20151211
Språk : Engelska
their colleagues.
0707890607
0707890607
Lalit Kumar
Lalit.Kumar@ki.se
Title : Brain circuits
Kursnummer : 2624
Datum : 20150907 20150911
Språk : Engelska
Särskild behörighet : Kursens lärandemål : By the end of the course the student shall be able to: Explain the structure and
function of main neuronal circuits in the brain. Describe the principles for excitatory and inhibitory
networks, including receptors and neurotransmittors, as well as the action of different chemical
neuromodulators. Describe principles, use and readout of optogenetics and recording technologies. Describe
principles of viral labeling and tracing of neuronal circuits. Explain how dysfunctions of networks can
manifest as neuropsychiatric disorders. Describe animal behavior tests probing specific networks and
network functions.
Kursens innehåll : The course will cover the organization and function of main circuits in the brain,
including the interaction and participation of different cell types, the interplay between excitation and
inhibition, and how circuit output result in behavior. Different techniques for labeling and manipulation of
neuronal circuits will be discussed, including molecular targeting, optogenetics and transsynaptic viral
tracing. The connection between deficient circuit functions and neuropsychiatric disorder will be included, as
well as animal behavior tests probing specific circuits and circuit (dys)functions. Specific emphasis will be
put into describing the technologies currently used in the neuroscience field.
Arbetsformer : Lectures by invited experts and group exercises.
Examination : The student should in discussions and a seminar presentation demonstrate the ability to
critically evaluate original research papers on the topics covered and be able to show that the intended
learning outcomes for the course are reached. Obligatoriska moment : The seminar presentations are obligatory. Antal studenter : 16 28
Urval av studenter : We welcome highly motivated applicants from all areas of neuroscience. Basic
knowledge of how neurons function and of brain anatomy is a prerequisite to benefit from the course. Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project
according to the written motivation in the application, 2) date for registration as a PhD student (priority
given to earlier reg. date), 3) Experience of neuroscience research as stated in the written motivation. Övrig information : The course will be given in lecture hall Tellus, Department of Neuroscience, Scheeles
väg 1, Karolinska Institutet, Solna. Time: 9.0017.00 Monday to Friday. Invited teachers are international
scientists with important contributions to and expertise in their respective fields, often involving
development or application of novel technologies. Confirmed speakers: Karl Deisseroth Stanford University,
Peter Magill University of Oxford, Daniel Huber University of Geneva, Menno Witter NTNU Trondheim, Laura
Busse University of Tubingen, Ofer Yizhar Wiezmann Institute of Science, Jeremiah Cohen Johns Hopkins,
Konstantinos Meletis, Marie Carlén and Gilad Silberberg Karolinska Institutet, and more. Kursansvarig : Marie Carlen
0852483043
Marie.Carlen@ki.se
Kontaktpersoner :
Title : Neurodegenerative disorders I From molecule to
treatment
Kursnummer : 2629
Datum : 20151005 20151009
Språk : Engelska
Särskild behörighet : Kursens lärandemål : The student should after the course: 1) understand cellular processes and
molecular mechanisms of neurodegeneration 2) understand mechanisms of protein turnover, degradation
and aggregation 3) based on knowledge of these mechanisms critically be able to evaluate the concept of
conformational disorders and its relevance to the different neurodegenerative disorders 4) have achieved
basic knowledge about epidemiology, symptoms, pathology and current treatments of the most common
neurodegenerative disorders such as Alzheimers disease, Parkinsons disease, amyotrophic lateral sclerosis
and multiple sclerosis. 5) In addition, the student should understand how the pathology of these disorders
is reflected in their symptoms. 6) Based on this understanding, the student should be able to discuss the
effects of treatments, if they are (or may be) symptomatic or curative. 7) Be able to evaluate the relevance
of different disease models, their advantages and limitations with respect to the clinical picture and to what
is known about disease mechanisms.
Kursens innehåll : The course will cover topics related to the degeneration of neural cells, apoptosis and
necrosis as well as the cellular and biochemical reactions to neuronal injury. During the course we will also
present and discuss symptoms, diagnosis, pathology, epidemiology, genetics and treatment of the most
common neurodegenerative disorders such as Alzheimers disease, Parkinsons disease, amyotrophic lateral
sclerosis and multiple sclerosis. Molecular mechanisms of current and future treatment strategies, disease
models and their potential will be presented and discussed. In addition, the students may within group
assignments study less common neurodegenerative diseases such as frontotemporal dementia, Lewy body
disease, ataxias, prion diseases as well as vascular, inflammatory or trauma related causes of
neurodegeneration such as stroke, epilepsy or trauma.
Arbetsformer : The course runs day time for 1 week fulltime with lectures by invited scientists, literature
seminars as group assignments, and individual studies.
Examination : The examination part includes: the group assignments, the oral presentations by the
students and the following general discussion between all participants. All students are individually
assessed.
Obligatoriska moment : The group assignments, the oral presentations by the students and the following
general discussion between all participants are compulsory. Students that are absent from these parts will
have to individually submit a written presentation of the subject.
Urval av studenter : If selection of course participants is necessary, we will prioritize 1) students for
whom the course is mandatory, 2) students with an educational plan encompassing the topics of the
course, and 3) students close to thesis defence missing course on the topic.
Övrig information : The course will be held at Karolinska Institutet, Huddinge.
Kursansvarig : Elisabet Åkesson
08585 838 92 Elisabet.Akesson@ki.se
Kontaktpersoner : Helena Karlström
08585 837 77
Helena.Karlstrom@ki.se
Maria Roos
0858585417
Maria.Roos@ki.se
Title : Neurodegenerative disorders II cellular and molecular
mechanisms
Kursnummer : 2630
Datum : 20151012 20151016
Språk : Engelska
Särskild behörighet : Kursens lärandemål : The student should: Understand and critically evaluate relevant cellular and
molecular pathophysiological mechanisms of neurodegenerative disorders such as stroke, Alzheimer¿s
disease, frontotemporal dementia, Lewy body disease, Parkinson¿s disease, multiple sclerosis, amyotrophic
lateral sclerosis, ataxias, prion diseases, epilepsy and trauma, and the mechanisms of current and/or
possible future treatments. Understand and be able to perform the common assays of cell degeneration,
and discuss the results, taking into account the limitations of the assays. Be able to discuss the present
disease models, propose alternative models, and critically evaluate these models from the perspectives of
a) clinical picture, b) disease mechanisms, and c) treatment mechanisms. Kursens innehåll : The course is a continuation of the course Neurodegenerative disorders ¿ From
molecule to treatment, but it can also be taken as a separate course, provided the participant has in other
ways achieved the learning outcomes of that course. The course addresses topics in basic and clinical
research on neurodegenerative disorders, with a particular focus on the cellular and molecular mechanisms.
The focus will be on a deeper understanding of cellular and molecular mechanisms, and the techniques to
study them. Arbetsformer : The course runs daytime for 1 week fulltime with some key lectures by invited scientists,
laboratory practicals, literature seminars, and discussions in small groups and the entire class.
Examination : Written examination followed by group discussions on the examination questions, and a
general discussion between all participants.
Obligatoriska moment : Laboratory practicals, literature seminars and the exam (including the group
discussion after the exam) are compulsory. Students that are absent from literature seminars and/or
practicals will have to submit a written presentation of the subject.
Övrig information : Kursansvarig : Lars Tjernberg
Lars.Tjernberg@ki.se
Kontaktpersoner : Sophia Schedin Weiss
sophia.schedin.weiss@ki.se
Title : Human physiology an overview
Kursnummer : 2644
Datum : 20150914 20150925
Språk : Engelska
Särskild behörighet : Kursens lärandemål : The student will after completed course have an overview and understanding of
how the organ systems of the human body function and interact under normal conditions. The course
content will also be possible to use for further studies in a PhD education where knowledge about human
biology is of value. More specifically, the student will be able to: Demonstrate knowledge about basic
functions of and interaction between organ systems. Assemble and share information in selected areas.
Demonstrate a critical and scientific attitude to literature sources for the different course tasks. Kursens innehåll : Overview of cellular and integrative physiology Basic anatomy and biochemistry
Physiology of the nervous system Endocrinology Digestion physiology Cardiovascular physiology
Renal physiology, fluid balance, acidbase balance Respiration Arbetsformer : Different learning forms such as problem based learning, lectures and a handson human
lab session. Full time during two consecutive weeks.
achieved. Assessment methods used are an oral quiz along with a written exam.
Obligatoriska moment : The examination tasks and the handson human lab are compulsory. Students
that are absent from the oral quiz or the handson lab will have to compensate it in agreement with the
course organizer. Students that are absent from the exam or do not obtain a passing grade in the first
examination will be offered a second examination.
Urval av studenter : Selection is based on 1) the date of admission to doctoral education 2) the relevance
of the syllabus to the doctoral projects of the applicants.
Övrig information : Lectures will take place in mornings and afternoons. Most of the lectures will take
place at von Eulers väg 4a/b, KI Solna. � Among the lecturers are Carl Johan Sundberg and Jessica
Norrbom.
Kursansvarig : Jessica Norrbom
Jessica.Norrbom@ki.se
Kontaktpersoner : Charlotte Schönbeck
charlotte.schonbeck@ki.se
Title : Människans fysiologi en översikt
Kursnummer : 2644
Datum : 20150907 20150918
Språk : Svenska
Särskild behörighet : Kursens lärandemål : Studenten ska efter genomgången kurs ha översiktlig kunskap och förståelse för
hur människokroppens organsystem fungerar och samverkar under normala betingelser. Kursinnehållet ska
kunna användas för fortsatt fördjupning inom en forskarutbildning där vissa humanbiologiska kunskaper är
av värde. Färdigheter Muntligt kunna redogöra för organsystemens funktion. Sammanställa och delge
information muntligt och skriftligt för utvalda fördjupningsområden. Förhållningssätt och
värderingsförmåga Uppvisa ett kritiskt och vetenskapligt förhållningssätt till litteratur som inhämtas för
olika fördjupningsuppgifter. Kursens innehåll : Översikt av cellulär och integrativ fysiologi Basal anatomi och biokemi
Nervsystemets fysiologi Endokrinologi Digestionsfysiologi Hjärt cirkulationsfysiologi Njurfysiologi,
vätskebalans, syrabasfysiologi Respiration Arbetsformer : Kursen innehåller delvis problembaserad undervisning, föreläsningar och en praktisk
laboration. Examination : För att bli godkänd i kursen måste studenten visa att lärandemålen har uppnåtts. Detta
bedöms genom en muntlig dugga och en skriftlig tentamen. Obligatoriska moment : Moment som är obligatoriska är examinationsuppgifter och praktisk laboration.
Vid eventuell frånvaro vid muntlig dugga eller laboration kompenseras detta i överenskommelse med
kursens koordinator. I anslutning till kursen ges ett resttentamenstillfälle. Antal studenter : 10 20
Urval av studenter : Urval sker utifrån 1) datum för doktorandregistrering (där tidigare
registreringsdatum har förtur) 2) utifrån kursplanens relevans för sökandes doktorandprojekt (enligt
motivering). Övrig information : Föreläsningar är fördelade under förmiddag och eftermiddag och äger rum vid KI
Campus, Solna. Doktorander har en del gemensamma föreläsningar med kursdeltagare från den fristående
kursen Människans Fysiologi. Bland föreläsarna finns bland annat Håkan Westerblad och Carl Johan
Sundberg. Kursansvarig : Carl J Sundberg
0852486886
Carl.J.Sundberg@ki.se
von Eulers väg 8
17177
Stockholm
Title : Surgical Techniques in Rat and Mouse
Kursnummer : 2647
Datum : 20150921 20150925
Språk : Engelska
Kursansvarig institution : Comparative medicine
Särskild behörighet : Passed both Laboratory Animal Science for Researchers Rodents and Lagomorphs
AND Laboratory Animal Science for Project Directors, OR have a FELASA C certificate.
Kursens lärandemål : After the course the participants are expected to be able to: 1. handle pre, peri and
postoperative care of rats and mice, including asepsis and analgesia 2. recognize microsurgery instruments
and their use 3. set and use a microsurgery microscope 4. use appropriate suture materials 5. catheterize
blood vessels and to collect blood Kursens innehåll : Analgesia and perioperative care, aseptic surgical techniques, basic surgical techniques
including instrumentation, suturing and tissue handling, vein and artery cannulation, explorative laparotomy
and blood sampling techniques. Rat will be our main animal model during the course (as techniques are
easier to learn in a larger model), but mouse will also be available.
Arbetsformer : A minor part of the learning activities are lectures (10%). The laboratory activities account
for 70 % of the course. The remaining part of learning activities are demonstrations and project work
(tutoring available). Examination : Assessment of learning outcomes To satisfactorily complete this course the participant
must: 1) be able to perform a jugular vein cannulation and to perform blood sampling techniques 2) write a
report of provided fictive research projects or of participant's own research project
Obligatoriska moment : The presence of participants is required during all scheduled moments. Absence
to lectures can be compensated by a written task. The laboratory moments are compulsory. A retake
might be offered at the next course. Antal studenter : 10 16
Urval av studenter : The course offers very few places and only applications from PhD students registered
at Karolinska Institutet will be considered. The relevance of microsurgery to the applicants research project,
will also be considered.
Övrig information : The course will take place at Comparative Medicine Learning Lab in Solna. Professor
René Remie from the Netherlands and Professor Michael Axelsson from Gothenburg University, both experts
on microsurgery techniques in rodents, are the course leaders. The course is to 95% practical. One week
full time labs.
Kursansvarig : Dude Gigliotti
Komparativ medicin
0852486529
Dude.Gigliotti@ki.se
von Eulers väg 4a, plan 4
171 77
STOCKHOLM
Kontaktpersoner :
Title : Mesenchymal stem cells biology and clinical potential.
Kursnummer : 2652
Datum : 20151012 20151016
Språk : Engelska
Särskild behörighet : None. Kursens lärandemål : After the completed course, the student will be able to describe the basics of stem
cell biology and transplantation and a number of novel technologies and approaches in mesenchymal stem
cell research and regenerative medicine. The student can demonstrate an interdisciplinary understanding of
central concepts in mesenchymal stem cell science and critically evaluate different methods and techniques
used. The student will be able to extract and integrate information from stateoftheart lectures in
combination with overview articles and literature searches on the internet within the research field.
Kursens innehåll : The course covers key concepts in translational research on mesenchymal stem cells
from the laboratory to the patient in the clinic. This includes a general overview of stem cell biology,
transplantation immunology, mesenchymal stem cell history, sources, homing and circulation and
interaction with the immune system. Experts will give an advanced summary of the latest events in the
mesenchymal stem cell field. The student will be required to take an active part, contribute and value
discussions on ethical dilemmas in the transplantation area and in workshops on relevant topics in the
mesenchymal stem cellfield. Networking with students and speakers is highly encouraged in this course.
Arbetsformer : The pedagogic framing of this course is based on lectures with corresponding review
papers. The course includes workshops with illustrative predicaments where the students are required to
take an active part in the discussions. Group discussions and workshops will be conducted where the
students discuss and integrate information from the lectures and review papers. The students prepare and
present their examination task in a written report that is handed in after the course.
Examination : Individual written project report that will be performed and handed in at the end of the
course. The individual performance of each student will be evaluated separately.
Obligatoriska moment : The lectures, workshops and discussions are mandatory. Compensation
according to the instructions of the course director.
Urval av studenter : The selection process will be based on a comprehensive assessment of the students: 1. Motivation for the course 2. Topic of their PhD project 3. Years since PhD registration
Övrig information : The course is coorganised with the Swedish network for Mesenchymal stem cell
biology and is given at Karolinska Institutet in Huddinge. Invited international key experts in the
mesenchymal stem cell field will lecture at the course. The examination task (written report) will be handed
in after the end of the course.
Kursansvarig : Katarina Le Blanc
Katarina.Leblanc@ki.se
Kontaktpersoner :
Title : Grounded Theory in Health Research
Kursnummer : 2654
Datum : 20151130 20151211
Språk : Engelska
Kursansvarig institution : Department of Clinical Science and Education, Södersjukhuset
Särskild behörighet : Kursens lärandemål : At the end of the course the participants should: 1. Be able to describe the
experience of a classroom climate that incorporates principles of respect, mutuality, cooperation,
collaboration, and teamwork. 2. Be able to demonstrate understanding of philosophical and practical
underpinnings of grounded theory. 3. Be able to express understanding of the essential characteristics of
grounded theory and exploration methodology. 4. Be able to apply knowledge of grounded theory in
discussing rationales for design of grounded theory study. 5. Be able to understand and assess the
applicability of a grounded theory methodology for a particular research problem. 6. Be able to critically
comment/evaluate strength and weakness of studies(published papers) using grounded theory methodology
7. Be able to implicate grounded theory research findings for practice and future research 8. Be able to
design grounded theory research proposals including: Title, Background, Research question, Study goal and
objectives, Methodology and reasons to choose grounded theory methodology, Study population, Study
sample (participants), Sampling method, Sample size, Inclusion and exclusion criteria, Data gathering
technique/s, Data analysis method, Limitation, Ethical consideration, Trustworthiness/ Credibility(validity&
reliability) Kursens innehåll : The course will provide practical, handson experience in using grounded theory
research. Students will gain a knowledge and understanding of main features and the basic characteristics
of grounded theory, the applicability of grounded theory for particular research problems, including those of
their own original grounded theory research projects; and how to critically appraise appropriateness of
grounded theory. The teachers will share their experience of grounded theory research method, the
application of grounded theory in their respective fields and provide advice and consultation on the
advanced use of cuttingedge grounded theory. The course will start with a deep discussion about what
grounded theory is, the aim of grounded theory and when to use grounded theory. Then teachers will
continue with key characteristics of grounded theory research, the applicability of grounded theory for
particular research problems, how to conduct a grounded theory study; and evaluation of rigor in this
approach. Students will learn to evaluate and make comments on published grounded theory studies in
terms of methodology, data gathering, quality of gathered data, data analysis approach, display of result,
study limitation and ethical considerations. Finally implications of grounded theory findings for practice and
future research will be discussed and students will learn to design a grounded theory research proposal in
their respective fields. Arbetsformer : The learning activities of the course are a mix of lectures, discussions, individual and group
activities; interviews, seminars, field observations and individual and group presentations.
Examination : The course assessment will include formative and summative assessments. The formative
assessment (50%) will be made through Peer learning Activity, critic a grounded theory paper, individual
and group presentations, while the summative assessment (50%) will be through a written examination,
and individual qualitative data gathering and analysis and finally a written grounded theory proposal in their
respective fields. In this way, the students are examined with both groupwise and individual presentations.
Obligatoriska moment : Active participation in the class discussions, individual and group assignments
(individual and group data gathering by interviews and field observations and data analysis), written
assignment (a complete grounded theory proposal) and student presentations are mandatory.
Compensation according to the instructions of the course director, which means absentees less than 2
lectures is acceptable and should be compensated by individual projects related to absentee¿s session.
Övrig information : The course is held at Department of Clinical Science and Education at Södersjukhuset
in Stockholm. Kursansvarig : Hamid Khankeh
hamid.khankeh@ki.se
Sjukhusbacken 10
118 83 Stockholm
Kontaktpersoner : Jeanette Brynholt Ohrman
086162935
jeanette.brynholt.ohrman@ki.se
Title : Introduktionskurs i R datahantering, analys och grafisk
presentation
Kursnummer : 2657
Datum : 20151105 20151127
Språk : Svenska
Särskild behörighet : Grundläggande statistikkunskaper (motsvarande "Grundläggande kurs i medicinsk
statistik")
Kursens lärandemål : Efter kursen ska doktoranden kunna använda R för datahantering, statistisk analys
och grafisk presentation av data. Man ska också kunna installera nya funktioner i R. Kursens innehåll : R är ett kraftfullt program/programspråk för analys och grafisk presentation av data. R
är helt kostnadsfritt och i de flesta ett fullgott alternativ till kommersiella statistikprogram. Programspråket
är helt textbaserat vilket gör det svårare att komma igång med jämfört med program som har ett grafiskt
gränssnitt. När man behärskar det ger det dock en större flexibilitet, bättre kontroll över analyserna och en
automatisk dokumentation av utförda analyser. Kursens fokus ligger på struktur och grundläggande
funktioner i programspråket R. Därutöver presenteras ett urval av funktioner för datahantering, statistisk
analys och grafik. De metoder som tas upp är sådana som vanligen används inom klinisk medicinsk
forskning (t.ex. ttest, chi2test, regressionsanalys, överlevnadsanalys, boxplot, linje, punkt, stapel och
cirkeldiagram). Kursen fokuserar på hur de statistiska metoderna utförs i R och inte t.ex. deras teoretiska
bakgrund, användningsområden eller tolkning.
Arbetsformer : Föreläsningar och praktiska övningar.
Examination : Varje kursdag avslutas med praktiska övningsuppgifter som löses enskilt. Korrekta
lösningar krävs för godkänd kurs.
Obligatoriska moment : Föreläsningar och inlämningsuppgifter är obligatoriska.
Övrig information : Kursdatum: 56/11, 13/11, 20/11, 27/11. Egen laptop behövs för de praktiska
övningarna. Kursen hålls vid Karolinska Universitetssjukhuset, Huddinge.
Kursansvarig : Jonatan Lindh
0858581201
Jonatan.Lindh@ki.se
Avd. för klin. farmakologi, C1:68
Karolinska universitetssjukhuset Huddinge
14186
Stockholm
Kontaktpersoner : Marine Andersson
08585 81064
Marine.Andersson@ki.se
Title : Metoder för statistisk analys: Från variansanalys till
multilevel modeling
Kursnummer : 2666
Datum : 20151012 20151030
Språk : Svenska
Särskild behörighet : Kursens lärandemål : Efter genomgången kurs ska studenterna kunna använda sig av följande statistiska
analysmetoder: (1) Variansanalys; (2) Multipel regressionsanalys; (3) Risk och Oddskvoter; (4) Logistisk
regression; (5) Cox regression; (6) Faktoranalys; (7) Strukturekvationsmodellering; (8) Multilevel Modeling.
Kursens innehåll : De ovan angivna statistiska analysmetoderna.
Arbetsformer : Kursen består av föreläsningar och datorövningar. Föreläsningarna kommer att täcka det
teoretiska materialet och beskrivas med relevanta exempel. I datorövningarna kommer de olika
analysmetoderna att användas på givna data. Vid datorövningarna används programmet SPSS.
Examination : Kursen examineras genom att studenterna utför de i kursen ingående analysmetoderna
samt presenterar och tolkar resultaten från dessa i form av en skriftlig rapport.
Obligatoriska moment : Inga obligatoriska moment.
Övrig information : Datum med undervisning: 8/10; 14/10; 15/10; 19/10, 22/10; 27/10; 29/10; Vi håller
till i Huddinge; En stor del av undervisningen finns tillgänglig på nätet.
Kursansvarig : Kimmo Sorjonen
Kimmo.Sorjonen@ki.se
Title : Evidensbaserad verksamhet inom hörsel, öron, språk och
tal
Kursnummer : 2668
Datum : 20150901 20151218
Språk : Svenska
Särskild behörighet : Kursens lärandemål : formulera och motivera en klinisk/motsvarande forskningsfråga inom verksamhet
och forskningsfälten hörsel, öron, språk eller tal självständigt söka information i primära och sekundära
informationskällor och granska informationen kritiskt i enlighet med utvald evidenshierarki eller kriterier
redogöra för och beräkna power samt visa förmåga att analysera effektstyrka reflektera över betydelse
och konsekvenser för verksamheten samt förmedla dessa presentera, diskutera och argumentera för
tillvägagångssätt och resultat skriftligt och muntligt
Kursens innehåll : Kursdeltagarens kliniska/annan erfarenhet och nuvarande forskningsområde ligger till
grund för formulering av en forskningsfråga inom området. Kritisk granskning av befintlig evidens
sammanställs och analyseras med relevanta statistiska metoder. Resultatet bearbetas för skriftlig och
muntlig presentation för olika målgrupper (t ex forskare, kliniker samt målgrupp i det omgivande
samhället).
Arbetsformer : Föreläsningar i metod och statistik, eget arbete och gruppövningar i granskningsprocessen,
handledning samt seminarier
Examination : Samtliga lärandemål examineras genom den skriftliga och muntlig rapporteringen.
Obligatoriska moment : Seminarier. Form för kompensation av ev frånvaro beslutas i samråd med
kursansvarig
Övrig information : Forskarutbildningskursen ges parallellt som kurs på avancerad nivå (då med annan
kursplan och annan examinationsuppgift).
Kursansvarig : Ellika Schalling
0858587411
Ellika.Schalling@ki.se
Kontaktpersoner : Christina Hedestedt
christina.hedestedt@ki.se
Title : Tumor microenvironment
Kursnummer : 2671
Datum : 20151123 20151127
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After completion of the course, the students will be able to describe and discuss the
tumor microenvironment and how it contributes to the carcinogenic process.
Kursens innehåll : The course is designed for PhDstudents with an interest in tumor biology. It consists
of lectures and experimental demonstration. The course will specifically address the concepts of tumor
associated fibroblasts and macrophages, hypoxia, tumor metabolism, metastasis and tumor vascular
angiogenesis and lymphangiogenesis. Experimentally, students will be able to describe the advantages and
pitfalls of laser dissection.
Arbetsformer : The course will be organized with a series of lectures, experimental demonstration, group
discussion and examination at the final day.
Examination : To pass the course the learning outcomes of the course must be reached. This will be
evaluated individually during the group discussion and based on the written exam.
Urval av studenter : Selection of students will be based on personal motivation and the relevance of the
course content for their research. Priority will be given to registered doctoral students at KI. If necessary, a
further selection will be based on the date for registration as a doctoral student.
Övrig information : The course will be held at CCK lecture Hall, R8:00, Karolinska University Hospital,
Solna.
Kursansvarig : Yujuan Zheng
yujuan.zheng@ki.se
Kontaktpersoner : Teresa Frisan
0852486385
Teresa.Frisan@ki.se
Berzelius väg 35
S17177
Stockholm
Title : Introduction to teaching at KI
Kursnummer : 2686
Datum : 20150902 20151007
Språk : Engelska
Särskild behörighet : Kursens lärandemål : At the end of the course we expect you to: Be able to explain general aspects of
how to facilitate student learning in different teaching situations Be able to reflect upon own teaching
experiences and use educational concepts in a discussion about teaching and learning Kursens innehåll : During the course we will discuss and elaborate on practical issues regarding teaching
and learning in laboratory, seminars and lectures. We will discuss and work with ways to challenge students
and what to do to facilitate their learning. Course participants will observe (auscultate) teaching and reflect
upon their experiences. We will touch upon the role of the teacher and KI teaching policies as well as
strategies for coping with stress.
Arbetsformer : The course is designed to promote active learning and a variety of teaching and learning
strategies will be used during the course. Examples are lectures, small group discussion, peer teaching,
group work, literature studies, auscultation of teaching and reflection in groups. Examination : To satisfactorily complete this course you must demonstrate that you have reached the
learning outcomes by orally presenting your reflections of literature studies and auscultation of teaching. Obligatoriska moment : The assessment seminar the last day of the course is mandatory. If absent, the
student need to present his/her knowledge at a separate occasion.
Urval av studenter : Priority will be given to doctoral students who have just started or soon will be
involved in teaching and that have no teacher training.
Övrig information : The course is scheduled 2 September, 15 September and 7 October. In addition, time
for reading and auscultation must be planned by the course participants.
Kursansvarig : Juha Nieminen
juha.nieminen@ki.se
08524 837 89
Title : Multidisciplinary perspectives on active ageing research
Kursnummer : 2688
Datum : 20150921 20151217
Språk : Engelska
Särskild behörighet : Kursens lärandemål : The students shall be able to: Theorize on complexity of research directed towards
older people, and reflect on methodological challenges in ageing research Analyse research on ageing from
a multidisciplinary perspective within the framework of different ageing theories Critically judge and
hypothesize on research questions within the field of ageing from different disciplinary viewpoints Kursens innehåll : To reach the intended learning outcomes, the course will be built on the research
projects of the students involved. Definitions and concepts relevant for the focus of those projects will be
penetrated to make students aware of their own frame of reference and of the theory that forms a base for
their research design. The course will include an overview of current ageing research issues within
different professional and scientific domains in health, covering the four levels health promotion, prevention
of disease and disability, rehabilitation and preservation of function. A focus on a persons resources for
developing an active life, and their possible implications in research will be analysed.
Arbetsformer : Lectures, seminars, study of and group discussions on scientific literature and individual
work based on each student's research project.
Examination : The students will be examined at a seminar, where a written assignment related to the
students research project will be presented, discussed and evaluated. The paper should include an attempt
to apply the perspective of empowerment as well as a multidisciplinary approach on the project. Obligatoriska moment : Active participation in the seminars, which are mandatory. Absence from a
seminar must be compensated by means of a written task, suggested by the course leader.
doctoral project (according to written motivation), 2) the usefulness for the applicant's future research.
Övrig information : The dates for the course meetings are September 21, October1213, December 16
17, from 9.0016.00. The meetings will take place in Flemingsberg, Alfred Nobels allé 23. Doctoral students
from various disciplines are welcome to apply.
Kursansvarig : Elisabeth Rydwik
elisabeth.rydwik@ki.se
Elisabeth Rydwik
elisabeth.rydwik@ki.se
Title : Basic Laboratory Safety
Kursnummer : 2690
Datum : 20151109 20151116
Språk : Engelska
Särskild behörighet : Experience of and/or education in laboratory work
Kursens lärandemål : After successfully completing this course you as a student should be able to
evaluate the risks associated with experiments in the laboratory. The hazards could originate from
chemicals, microbiological agents, cell cultures and human blood/tissues. You should also be able to identify
the needs for suitable personal protective equipment, routines for waste management and transport. In
addition, you should be familiar with the regulatory framework that governs these topics, the basic needs of
a safe laboratory, and be able to identify the chain of responsibilities.
Kursens innehåll : The course aims at giving theoretical and practical knowledge on chemical and
biological aspects of laboratory safety. Topics will deal with writing risk assessments, chemical health risks
including allergy, cancer and flammable agents, handling and storage of dangerous chemicals, handling of
microorganisms and cell cultures including human blood and tissue samples, laboratory acquired infections,
biosafety measures including personal protection devices, ventilated workplaces, genetically modified
microorganisms, biosecurity and dual use, transport of dangerous goods, waste management and the
sustainable laboratory.
Arbetsformer : The information will be given as lectures, group discussions, practical sessions, web
tutorials and computer sessions during a total of six days.
Examination : The examination is based on an individual written examination and performance of an
approved risk assessment.
Obligatoriska moment : Presence during some activities, like introduction, group discussions, practical
sessions and examination, is compulsory according to schedule. Students can not compensate for absence
during compulsory activities, but are referred to coming courses for these activities.
Urval av studenter : Selection will be based on 1) date for registration as a doctoral student (priority
given to earlier registration date), 2) the relevance of the course syllabus for the applicants doctoral project
(according to written motivation).
Övrig information : Kursansvarig : Roland Möllby
0852487175
Roland.Mollby@ki.se
Kontaktpersoner : Ingela Djupedal
Universitetsförvaltningen
Ingela.Djupedal@ki.se
Åsa Belin
asa.belin@ki.se
Anne Eklöf
Anne.Eklof@ki.se
Title : Basic Laboratory Safety
Kursnummer : 2690
Datum : 20150928 20151005
Språk : Engelska
Särskild behörighet : Experience of and/or education in laboratory work
Kursens lärandemål : After successfully completing this course you as a student should be able to
evaluate the risks associated with experiments in the laboratory. The hazards could originate from
chemicals, microbiological agents, cell cultures and human blood/tissues. You should also be able to identify
the needs for suitable personal protective equipment, routines for waste management and transport. In
addition, you should be familiar with the regulatory framework that governs these topics, the basic needs of
a safe laboratory, and be able to identify the chain of responsibilities.
Kursens innehåll : The course aims at giving theoretical and practical knowledge on chemical and
biological aspects of laboratory safety. Topics will deal with writing risk assessments, chemical health risks
including allergy, cancer and flammable agents, handling and storage of dangerous chemicals, handling of
microorganisms and cell cultures including human blood and tissue samples, laboratory acquired infections,
biosafety measures including personal protection devices, ventilated workplaces, genetically modified
microorganisms, biosecurity and dual use, transport of dangerous goods, waste management and the
sustainable laboratory.
Arbetsformer : The information will be given as lectures, group discussions, practical sessions, web
tutorials and computer sessions during a total of six days.
Examination : The examination is based on an individual written examination and performance of an
approved risk assessment.
Obligatoriska moment : Presence during some activities, like introduction, group discussions, practical
sessions and examination, is compulsory according to schedule. Students can not compensate for absence
during compulsory activities, but are referred to coming courses for these activities.
Urval av studenter : Selection will be based on 1) date for registration as a doctoral student (priority
given to earlier registration date), 2) the relevance of the course syllabus for the applicants doctoral project
(according to written motivation).
Övrig information : Kursansvarig : Roland Möllby
0852487175
Roland.Mollby@ki.se
Kontaktpersoner : Ingela Djupedal
Universitetsförvaltningen
Ingela.Djupedal@ki.se
Åsa Belin
asa.belin@ki.se
Anne Eklöf
Anne.Eklof@ki.se
Title : Measuring physical activity with focus on wearable
monitors applications for clinical and epidemiological studies
Kursnummer : 2693
Datum : 20151023 20151123
Språk : Engelska
Särskild behörighet : Kursens lärandemål : The primary objective of the course is to promote high quality research in clinical
and epidemiological studies through understanding of principles for measuring physical activity and
methods for analyzing physical activity data. By the end of the course the student should be able to: 1.
Reflect on the concepts relevant for the relation between physical activity and health and understand
measurement principles for assessing these concepts and especially the principles of of wearable monitors
such as accelerometry. 2. Choose and justify the best method of choice for assessment of physical activity
in accordance with different research questions, study designs and populations. 3. Apply the best method of
choice for assessment of physical activity in relation to a specific research question. 4. Design a validation
or calibration study in clinical and/or epidemiological studies in different populations. 5. Analyse physical
activity data and interpret the outcomes in accordance with different research questions, study designs and
populations. Kursens innehåll : Assessment of physical activity using questionnaires and wearable monitors in
different types of studies Sensor development and measurement principles Calibration and validation
Different approaches handling and analyzing the data and outcomes Statistical considerations
Interpretation of results Arbetsformer : The course has the primary focus on measurement of physical activity using accelerometry
and its use in clinical and epidemiological studies. An overview of other methods to measure physical
activity such as questionnaires, heart rate monitoring or a combination of different physiological measures
will also be covered. The course is based on demonstrations, workshops and seminars in combination with
a few lectures in order to promote a reflective, analytical and critical approach towards this research field.
Students will be encouraged to be interactive in demonstrations, workshops and seminars. There will be
handson experience with students wearing accelerometer throughout a week and opportunities for
exploring, processing and analysis this data. Examination : The learning outcomes will be examined by a written assignment were the students apply
the course content to their own doctoral projects. The written assignments will be presented and discussed
in a seminar where the students are respondents and opponents on each other¿s work. After the seminar
the students will be given one week to refine their work based on the feedback they are given.
Obligatoriska moment : Active participation in workshops and seminars. Absence from a seminar must be
compensated by means of a written task, suggested by the course leader.
Övrig information : The course is given in English. Localities will be KI Campus Huddinge, Alfred Nobels
Alle 23. Course days are planned to Oct 23, Nov 24th and an examination day Nov 23. There will be
assignments to do during the period of the course. The platform PingPong will be used for online learning,
discussions and documents. The course consist of lectures, lab and seminars. Professor Malcom Granat,
Professor Ulf Ekelund and Associate Professor Örjan are invited lecturers.
Kursansvarig : Maria Hagströmer
0852488836
Maria.Hagstromer@ki.se
Kontaktpersoner :
Title : Metoder för systematisk litteraturöversikt
Kursnummer : 2704
Datum : 20150907 20151215
Språk : Svenska
Särskild behörighet : Kursens lärandemål : Efter avslutad kurs förväntas deltagarna: *kunna reflektera över vilket bidrag den
egna forskningsöversikten tillför kunskapsfältet och identifiera frågor som kvarstår *ha utvecklat
färdigheter i användandet av forskningssyntes som en vetenskaplig process *kunna kritiskt utvärdera
procedurer vid systematiska litteraturöversikter
Kursens innehåll : Utveckla färdigheter att: *använda systematiskt tillvägagångssätt och att sammanfatta
kunskap utifrån en vetenskaplig process *reflektera över hur den valda frågeställningen inom ramen för
avhandlingsarbetet bidrar till kunskapsbasen inom aktuellt forskningsområde Centralt i kursen är att
utveckla färdigheter att använda systematiskt tillvägagångssätt och att sammanfatta kunskap utifrån en
vetenskaplig process. Olika syften och metoder för forskningsöversikter exemplifieras. Processen i en
systematisk litteratur översikt karaktäriseras av en tydligt formulerad fråga som besvaras genom
systematiska och explicita metoder för att identifiera, välja ut, kritiskt bedöma och analysera relevanta
studier utifrån frågeställningen. Arbetsformer : Kursen tillhandahåller en introduktion i metoder för systematisk litteraturgenomgång. Kursdeltagaren utvecklar ett protokoll för och genomför en systematisk litteraturgenomgång som fokuserar
på en valfri komponent/aspekt som kommer att appliceras i deltagarens eget avhandlingsarbete. Kritiskt
bedöma och diskutera svagheter och styrkor i det egna och kursdeltagarnas protokoll och översikter
(reviews). Kursen är en distanskurs på deltid som omfattar tre till fyra tillfällen om 12 dagar varav ett är
slutseminarium. Under kursen varieras arbetsformerna med t.ex. föreläsningar, eget arbete, granskning av
andras arbete och gruppdiskussioner, för att kursdeltagarna utifrån denna erfarenhet ska kunna reflektera
över hur kunskapen inom det egna forskningsfältet byggs upp. I kursen får deltagarna prova på att arbeta
systematiskt utifrån principer om forskningssyntes och även bearbeta och kritiskt granska olika procedurer
för forskningsöversikter. Vid första tillfället diskuteras frågeställningen och hur den valda komponenten
inom ramen för det egna avhandlingsarbetet kan användas i studentens egna forskning. Till andra tillfället
görs en individuell skriftlig plan eller protokoll för hur man implementerar en systematisk forskningsöversikt
utifrån frågeställningen om den valda komponenten (23 sidor, 1,5 radavstånd, 12 punkter Times, Roman).
Uppgiften skickas i form av ett word dokument (döpt med ditt namn). Examination : Kursen examineras individuellt genom muntlig och skriftlig examination i form av en
systematisk forskningsöversikt. För godkänd kurs krävs att lärandemålen är uppfyllda, vilket innebär
godkänt resultat på den skriftliga examinationen samt aktivt deltagande i obligatoriska delar. Examinationen består av: 1) En individuell uppsats i formen av en systematisk översikt och består av en
litteratur genomgång utifrån den valda frågeställningen (812 sidor, 1,5 radavstånd, 12 punkter Times
Roman Fokus i den sista uppgiften kommer att vara på: a) hur kursdeltagaren har undersökt och
sammanfattat den valda frågeställningen i den individuellt genomförda forskningssyntesen b) hur
studenten, i en metoddiskussion, har kritiskt granskat procedurer i den egna systematiska genomgången 2) Aktivt deltagande i det sista seminariet, där den individuella uppgiften (punkt 1) presenteras och
diskuteras. Examination för kursen kommer att tillhandahållas under ett år efter kursens slut. Obligatoriska moment : Deltagandet i slutseminariet är obligatoriskt. Frånvaro från det sista seminariet
ska kompenseras med en skriftlig kritisk diskussion av en annan students skriftliga rapport till det sista
seminariet.
Urval av studenter : 1. Doktorander i Forskarskolan i vårdvetenskap har företräde över andra sökanden.
 2. Doktorander har företräde över andra sökanden 3. KI doktorander har företräde över
andra doktorander 4. Motivering Övrig information : Kursen är en distanskurs på deltid som omfattar fem till sex tillfällen om 12 dagar
varav ett är slutseminarium. Tider och lokal Tillfälle 1: 7 september, 9.0016.00 Tillfälle 2: 8 september, 9.0016.00 Tillfälle 3: 9 september, 9.0016.00 Tillfälle 4: 1 oktober,
9.0016.00 Tillfälle 5: 5 november, frivillig handledning, OBS detta datum kan komma att ändras i
samråd med er! Tillfälle 6: (detta sker i halvklass och ni kommer att närvara en av de två dagarna):
14 eller 15 december, 9.0016.00 Samtliga tillfällen är på Solna campus. De två första
tillfällena består av föreläsningar och hjälp att starta upp ert egna arbete. Föreläsare under dessa dagar är
Agneta Pettersson, (projektledare från SBU, Statens beredning för medicinsk utvärdering), Yvonne
Wengström (Karolinska Institutet) och Petter Gustavsson (Karolinska Institutet). Vid tillfälle tre får ni
personlig hjälp i bibliotekets lokaler av bibliotekets kunniga personal. Dessa tre tillfällen är viktiga för att
komma igång med arbetet. Kontaktperson: Ann Rudman Kursansvarig : Ann Rudman
0739343478
Ann.Rudman@ki.se
Title : Hematopoiesis and hematopoietic stem cells in health and
disease
Kursnummer : 2717
Datum : 20151026 20151030
Språk : Engelska
Kursens lärandemål : After the completed course, the student will be able to describe the basics of
hematopoietic stem cell development, stem cell transplantation, development of different types of leukemia
and a number of novel technologies and approaches for hematopoietic stem cell research and clinical
treatment. The student will be able to demonstrate an interdisciplinary understanding of central concepts in
hematopoietic stem/progenitor cells, regulation of hematopoiesis, engraftment and immunological aspects
of stem cell transplantion and critically evaluate different methods and techniques used. The student will be
able to extract and integrate information from stateoftheart lectures in combination with overview
articles and literature searches on the internet within the research field. Kursens innehåll : The course covers key concepts in hematology from the laboratory to the patient in the
clinic. This includes visits to hematology clinic including bone marrow sampling and ward round as well as
laboratory demonstration. There will be a general overview of hematology including development of fetal
and adult hematopoiesis, molecular regulation of hematopoiesis, leukemic stem cells, immunological
consideration in stem cell transplantation, future treatment, stem cell homing and summary of the latest
events in the normal development of hematopoiesis as well as development and treatment of hematological
disorders including myeloid and lymphoid leukemia. The student will be required to take an active part,
contribute and value discussions on stem cell transplantation. Arbetsformer : The pedagogic framing of this course is based on lectures with corresponding review
take an active part in the discussions. Group discussions/workshop will be conducted where the students
discuss and integrate information from the lectures and review papers. The students prepare and present
their examination task in a written report that is handed in after the course.
Examination : Individual written project report that will be performed and handed in at the end of the
course. The individual performance of each student will be evaluated separately. Obligatoriska moment : The lectures and discussions are mandatory. Compensation according to the
instructions of the course director.
Urval av studenter : The selection process will be based on a comprehensive assessment of the students: 1. Motivation for the course 2. Topic of their PhD project 3. Registration date (priority given to students
with earlier registration date)
Övrig information : The course is given in Huddinge.
Kursansvarig : Julian Walfridsson
julian.walfridsson@ki.se
Kontaktpersoner : Julian Walfridsson
julian.walfridsson@ki.se
Title : Culture and Brain
Kursnummer : 2721
Datum : 20150901 20160215
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course students should be able to describe the interplay between culture
(in a wide sense of the word) our brain and health, wellbeing and learning. They shall also be able to
explain different scientific paradigms by which such questions are studied. Specifically, students shall be
able to 1) give examples of how experience and performance of culture are perceived by the brain, 2) give
examples of how culture might be used in prevention, health care and rehabilitation, 3) also give examples
where brain and educational science meet and inform each other, 4) discuss possible mechanisms, and 5)
propose further studies that will increase and enhance our understanding of the field.
Kursens innehåll : Inspired by the fast development in the cross disciplinary field of culture brain health,
we will address questions concerning how activities and experiences in different fields of culture (music,
literature, fine arts, physical activity etc) are perceived by and affect the human brain in ways that influence
wellbeing, health, healing and rehabilitation, and also how processes and plastic structures in brain
influence learning. The course will cover questions such as how brain perceives culture, brain plasticity, use
of culture in health care and rehabilitation, and the crossroad between brain and educational research. The
course will touch upon a large number of different sorts of culture, and make students familiar with
different scientific paradigms in various academic disciplines studying these phenomena, and wide range of
different scientific approaches and techniques. Arbetsformer : In average 12 lectures each month for five months, each immediately followed by a
seminar, 23 hrs on each occasion. Lectures and seminars held by internationally leading scientists in the
fields, whose work quailify to be presented on the website "Kulturella hjärnan". (www.culturalbrain.se).
Every occasion consists of a appr 12 hour seminar/lecture with the invited expert followed by a two hour
open discussion, i.e 34 hours on each occassion. For each seminar the students will usually be given at
least one article on the topic to read. Active participation in discussions in groups with invited speaker of
high international standards is a key element. You also receive DVDrecordings of all lectures for further self
studies at home.
Examination : On an individual basis. Continuous by workshop discussions. Written homeexam (essay). Obligatoriska moment : The seminars are compulsory. Absence can be compensated for after discussion
with the course leader.
Övrig information : Kursansvarig : Ingemar Ernberg
+46852486262
17177
Stockholm
Kontaktpersoner : Bertha Brodin
51775244
Bertha.Brodin@ki.se
Cancer Centrum Karolinska CCK R8:00
171 76
Stockholm
Henrik Brändén
henrik.branden@ki.se
Title : Writing skills for science
Kursnummer : 2743
Datum : 20150813 20150816
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the completed course, the students will be able to explain and relate the basic
components of a good scientific manuscript in the IMRaD format, and demonstrate knowledge on the
different linguistic strategies for constructing sentences and paragraphs for improved readability and flow in
scientific manuscripts and other communications. Kursens innehåll : The course consists of two major parts: 1) A creative writing workshop focusing on the
use of creative writing techniques for improved communication in science and in general, and in using text
as a tool in communication. The creative writing workshop includes writing exercises and readings and
discussions. 2) A scientific writing workshop on writing IMRaD style articles including exercises in analysing
the structure of published papers. The workshop includes perspectives from an editor's point of view about
factors affecting rejection or acceptance of a paper.
Arbetsformer : The course includes presentations, readings, writing exercises and text analysis exercises. Examination : The students will be examined on the basis of their active participation in individual
exercises (writing exercises and IMRaD style article analysis). Obligatoriska moment : The writing and text analysis exercises and readings are obligatory. Absence
from compulsory parts is compensated according to the instructions from the course directors.
Övrig information : This writing course is organised as an intensive weekend camp at Solvik. Participants
will be able to enhance their creative and professional writing skills with instructors from Harvard Medical
School, Uppsala University and Karolinska Institutet in a relaxed small group setting. The course is free of
cost with basic summer camp food. The participants will live in shared accommodation and must bring their
own bed linen and towels. Solvik is located in a beautiful archipelago setting in Värmdö, just half an hour
from central Stockholm with public transport from Slussen.
Matti.Nikkola@ki.se
Kontaktpersoner :
Title : The Developing Brain
Kursnummer : 2780
Datum : 20150831 20150904
Språk : Engelska
Särskild behörighet : Kursens lärandemål : By the end of the course the student shall be able to describe the major steps
contributing for the development of the brain and transfer new knowledge acquired in the course into their
specific projects or fields of research. The student should be able to explain basic principles behind neural
development such as patterning, specification from neural stem cells to neurons and oligodendrocytes,
migration, neurite outgrowth, axon pathfinding, synapse formation, neuroglia interactions, the role of
neuronal activity, and regeneration final circuit integration. Describe key concepts such as epigenetic states,
cell potency and faterestriction, transcriptional programs. To apply and understand the readout of modern
methods of probing developmental questions including inducible genetic fatemapping, manipulation and
tissue culture systems in different animal model systems as well as transcriptomic analysis. Kursens innehåll : The course will cover the main developmental steps for creating the mature circuits in
the brain, including the patterning of the neural plate and thus the origin of cell types, the interplay
between intrinsic and extrinsic factors, neuroglia interactions and the role of network activity in shaping
the final circuits. Different molecular and tracing technologies, and model organisms will be covered. An
important aspect of the course regards molecular technologies for labeling, transcriptional analysis and
genetic manipulation of defined neural populations. Connections between aberrant developmental processes
and neurological disorders will be covered.
Arbetsformer : Lectures by invited experts, group work, seminar presentations.
Examination : The students should demonstrate their knowledge about the items stated as individual
learning outcomes during interaction with invited experts, group work and presentations. They should
demonstrate that they can critically evaluate original research papers on these topics in a seminar
presentation and in discussions.
Obligatoriska moment : All lectures and the seminar presentation (examination) are compulsory. Student
who cannot attend will be given the opportunity to perform an individual seminar presentation and take
part in an individual exam.
given to earlier registration date) Övrig information : The course is a full time course (09.0016.00) and will be given at the Department of
Neuroscience (Room Tellus, Scheeles väg 1, 5th floor). Confirmed external speakers are: Paola Arlotta,
Harvard, USA. Steve Goldman, Rochester Univ, USA. Yevgenia Kozorovitskiy, Northwestern, USA. Denis
Jaubadon, Univ. Geneva, CH. Eve Seuntjens, GIGANeuroscience, BE.
Kursansvarig : Jens HjerlingLeffler
Institutionen för medicinsk biokemi och biofysik
jens.hjerlingleffler@ki.se
Kontaktpersoner : Goncalo CasteloBranco
Goncalo.CasteloBranco@ki.se
Title : Present your research!
Kursnummer : 2787
Datum : 20150831 20151110
Språk : Engelska
Kursens lärandemål : The overall aim of the course is to give the Ph.D. student knowledge in presenting
research results orally with support of visual media like power point slides, whiteboard, flipchart and a
scientific poster. After attending the course, the Ph.D. Student should: 1. BE ABLE TO DESIGN AN ORAL
PRESENTATION IN AN ADEQUATE WAY WITH EMPHASIS ON : a. Setting goals and aims for the
presentation b. Structure of the presentation c. Simplification of research results in order to enhance the
understanding d. Choice of pictures e. Language f. Adjusting to different presentation types like poster
presentation, grant proposal, and for example your dissertation lecture, or presentation of your research
results to your research group, or a journal club g. Time management: how much time do I have at my
disposal and how to keep the time limits h. Basic rhetoric and presentation techniques 2. BE ABLE TO
DESIGN AND USE SUPPORTIVE MEDIA FOR A SUCCESSFUL PRESENTATION: a. Power Point slides ¿
interesting and structured, adjusted to the room conditions and the audience b. Scientific poster ¿
illustrative, good flow and conclusive c. Flipchart, whiteboard and other supporting media 3. KNOW THE
BASICS ABOUT HOW TO PRESENT (presentation techniques and rhetoric): a. Body language and posture b.
Language and pace c. How to prepare yourself for a presentation d. How to remember what you want to
present e. Building confidence (be less nervous) to present f. What to avoid doing during a presentation g.
How to deal with questions from the audience 4. HAVE GAINED KNOWLEDGE ON HOW TO INTERACT WITH
THE AUDIENCE: a. Catching the audience¿s attention b. Keeping the audience´s attention for a longer
period of time c. How to impress your audience d. How to address the audience e. Communicating with the
audience f. How to make the audience trust you g. Preparing the presentation with different audiences in
mind h. Different learning styles which influences the audience´s attention i. Attention curve of the
audience j. How to enhance the learning of the audience Kursens innehåll : The scope of the course is to design and give oral presentations of your research
results in different contexts. The main content of the course: 1. DESIGN AND DISPOSITION OF AN ORAL
PRESENTATION (poster presentation, grant proposal, short presentation of research results): a. Goals and
aims b. Structure c. Simplifications to enhance understanding d. Choice of pictures e. Language f. Time
management: how much time, keeping the time limits 2. PRESENTATION TECHNIQUES AND RHETORIC
FOR ORAL PRESENTATIONS: a. Body language and posture b. Language and pace c. How to prepare
yourself for a presentation d. How to remember what you want to present e. Building confidence (be less
nervous) to present f. What to avoid doing during a presentation g. How to deal with questions from the
audience 3. DESIGN AND USE OF SUPPORTING MEDIA FOR A PRESENTATION: a. Power Point slides
including introduction to power point b. Scientific poster c. Flipchart, whiteboard and other supporting
media 4. INTERACTION WITH THE AUDIENCE: a. Catching the audience's attention b. How to address the
audience c. Keeping the audience´s attention for a longer period of time d. Communicating with the
audience e. How to make the audience trust you f. Preparing the presentation with different audiences in
mind g. Different learning styles which influences the audience´s attention h. How to impress your audience i. Attention curve of the audience j. How to ease the learning of the audience 5. PRACTICAL EXERCISES: a. Presenting in front of an audience: i. Grant proposal ii. Poster presentation iii. Presentation of student´s
choice b. Presentation exercises in pairs or small groups c. Presenting to different audiences d. Body
language e. Language and pace f. How to use your audience as an asset g. How to interact with your
audience h. How to remember your presentation i. Give an receive feedback on presentations j. Deal with
nervousness and stay focused on your presentation k. Video recording of presentation with feedback from
different perspectives Arbetsformer : Lectures, written assignments, workshops, coaching, group work, and practical exercises
in groups and with peer.
Examination : Poster presentation including scientific poster, grant proposal presentation, and a
presentation of your own choice.
Obligatoriska moment : Three complete presentations (designed and presented to the class): q. Poster
presentation including a scientific poster b. Grant proposal presentation c. One presentation of the student
´s own choise Antal studenter : 16 18
Övrig information : Welcome to apply for Ph.D. course Present your research! The course takes place on
the following days: 31st of August, 1st OR 2nd of September, 22nd of September, 3rd of November, 10th of
November. The reason for giving the course over a longer period of time is to give you a chance to practice
the skills your learn during the course. This course is suitable for anyone that wants to improve his or her
presentation techniques skills; no matter if you are starting off on a beginner's level or if your skills are
quite advanced. You will be working together with very experienced teachers, both in groups and
individually, and we will focus on your individual needs. Different approachess and techniques are used
based on the latest research in the field and we focus a lot on the participant's individual needs in terms of
needs (aims, nervousness, structure, bodylangugage, voice etc) and different kinds of presentations that
you might need to give.
0707890607
0707890607
Title : Present your research!
Kursnummer : 2787
Datum : 20150825 20151109
Språk : Engelska
Kursens lärandemål : The overall aim of the course is to give the Ph.D. student knowledge in presenting
research results orally with support of visual media like power point slides, whiteboard, flipchart and a
scientific poster. After attending the course, the Ph.D. Student should: 1. BE ABLE TO DESIGN AN ORAL
PRESENTATION IN AN ADEQUATE WAY WITH EMPHASIS ON : a. Setting goals and aims for the
presentation b. Structure of the presentation c. Simplification of research results in order to enhance the
understanding d. Choice of pictures e. Language f. Adjusting to different presentation types like poster
presentation, grant proposal, and for example your dissertation lecture, or presentation of your research
results to your research group, or a journal club g. Time management: how much time do I have at my
disposal and how to keep the time limits h. Basic rhetoric and presentation techniques 2. BE ABLE TO
DESIGN AND USE SUPPORTIVE MEDIA FOR A SUCCESSFUL PRESENTATION: a. Power Point slides ¿
interesting and structured, adjusted to the room conditions and the audience b. Scientific poster ¿
illustrative, good flow and conclusive c. Flipchart, whiteboard and other supporting media 3. KNOW THE
BASICS ABOUT HOW TO PRESENT (presentation techniques and rhetoric): a. Body language and posture b.
Language and pace c. How to prepare yourself for a presentation d. How to remember what you want to
present e. Building confidence (be less nervous) to present f. What to avoid doing during a presentation g.
How to deal with questions from the audience 4. HAVE GAINED KNOWLEDGE ON HOW TO INTERACT WITH
THE AUDIENCE: a. Catching the audience¿s attention b. Keeping the audience´s attention for a longer
period of time c. How to impress your audience d. How to address the audience e. Communicating with the
audience f. How to make the audience trust you g. Preparing the presentation with different audiences in
mind h. Different learning styles which influences the audience´s attention i. Attention curve of the
audience j. How to enhance the learning of the audience Kursens innehåll : The scope of the course is to design and give oral presentations of your research
results in different contexts. The main content of the course: 1. DESIGN AND DISPOSITION OF AN ORAL
PRESENTATION (poster presentation, grant proposal, short presentation of research results): a. Goals and
aims b. Structure c. Simplifications to enhance understanding d. Choice of pictures e. Language f. Time
management: how much time, keeping the time limits 2. PRESENTATION TECHNIQUES AND RHETORIC
FOR ORAL PRESENTATIONS: a. Body language and posture b. Language and pace c. How to prepare
yourself for a presentation d. How to remember what you want to present e. Building confidence (be less
nervous) to present f. What to avoid doing during a presentation g. How to deal with questions from the
audience 3. DESIGN AND USE OF SUPPORTING MEDIA FOR A PRESENTATION: a. Power Point slides
including introduction to power point b. Scientific poster c. Flipchart, whiteboard and other supporting
media 4. INTERACTION WITH THE AUDIENCE: a. Catching the audience's attention b. How to address the
audience c. Keeping the audience´s attention for a longer period of time d. Communicating with the
audience e. How to make the audience trust you f. Preparing the presentation with different audiences in
mind g. Different learning styles which influences the audience´s attention h. How to impress your audience i. Attention curve of the audience j. How to ease the learning of the audience 5. PRACTICAL EXERCISES: a. Presenting in front of an audience: i. Grant proposal ii. Poster presentation iii. Presentation of student´s
choice b. Presentation exercises in pairs or small groups c. Presenting to different audiences d. Body
language e. Language and pace f. How to use your audience as an asset g. How to interact with your
audience h. How to remember your presentation i. Give an receive feedback on presentations j. Deal with
nervousness and stay focused on your presentation k. Video recording of presentation with feedback from
different perspectives Arbetsformer : Lectures, written assignments, workshops, coaching, group work, and practical exercises
in groups and with peer.
Examination : Poster presentation including scientific poster, grant proposal presentation, and a
presentation of your own choice.
Obligatoriska moment : Three complete presentations (designed and presented to the class): q. Poster
presentation including a scientific poster b. Grant proposal presentation c. One presentation of the student
´s own choise Antal studenter : 16 18
Övrig information : Welcome to apply for Ph.D. course Present your research! The course takes place on
the following days: 25th of August, 26th OR 27th of August, 21st of September, 2nd of November, 9th of
November. The reason for giving the course over a longer period of time is to give you a chance to practice
the skills your learn during the course. This course is suitable for anyone that wants to improve his or her
presentation techniques skills; no matter if you are starting off on a beginners level or if your skills are
quite advanced. You will be working together with very experienced teachers, both in groups and
individually, and we will focus on your individual needs. Different approachess and techniques are used
based on the latest research in the field and we focus a lot on the participant's individual needs in terms of
needs (aims, nervousness, structure, bodylangugage, voice etc) and different kinds of presentations that
you might need to give.
0707890607
0707890607
Title : How to conduct systematic reviews and metaanalyses
Kursnummer : 2790
Datum : 20151019 20151104
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After completion of the course the students should be able to: 1) Independently
plan and produce a study protocol to perform a systematic review and metaanalysis, including a detailed
description of the selection of the eligible studies and statistical methodology. 2) Critically reflect on other
students individual project work in a scientifically constructive way. 3) Interpret and critically evaluate
scientific studies relevant to the course content.
Kursens innehåll : The course is designed for PhD students, in particular those who are at an early stage
of their research education, and those with an interest in conducting systematic reviews and metaanalysis.
The content of the course is as follows: 1) Basic terms in systematic reviews and metaanalyses, 2) How to
write a study protocol for a systematic review, 3) How to perform a systematic literature search, 4) Data
extraction and quality assessment of included studies, 5) Statistical methods used in metaanalyses and
interpretation, 6) Problems and limitations of systematic reviews and metaanalysis, 7) Examination and
course evaluation. Throughout the course, the students will work on an individual project and will have to
peerreview the project of another student. Further, students will critically review and discuss relevant
scientific articles.
Arbetsformer : Lectures, seminars, individual article review, group discussions, practical sessions (one on
systematic literature search, one on statistical methods) and homework tasks will be used. The course
focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge,
rather than memorising facts. Therefore, much of the focus of the course is on the individual project where
students are required to develop a full study protocol including several important aspects covered in the
lectures, article reviews and group discussions. Students will also peerreview each other¿s projects and
this will form the basis for the final examination seminar.
Examination : To pass the course the student must actively participate in the course and pass the
examinations: 1) Individual project work: To develop a written comprehensive yet concise study protocol
including several important aspects as discussed during the course; 2) Peerreview of other students¿
projects followed by an oral presentation of their own project and opposition of other students projects
during the group examination; 3) Critically review scientific articles relevant to the course content and
participate actively in the seminars.
Obligatoriska moment : Compulsory attendance includes the scheduled lectures and seminars. Absence
will need to be replaced by individual assignments following discussion with the course coordinator, e.g.
article reviews, with written or oral followup.
Urval av studenter : Selection will be based on 1) Date of registration as a PhD student 2) suitability of
PhD project 3) The motivation to attend the course.
Övrig information : Kursansvarig : Nele Brusselaers
0851770942
nele.brusselaers@ki.se
UGIR Norra Stationsgatan 67
17176
Stockholm
Kontaktpersoner : Kalle Mälberg
kalle.malberg@ki.se
Title : Medical developmental biology
Kursnummer : 2794
Datum : 20150817 20150821
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course the doctoral student is expected to be able: To fully understand
and review the basic biology and definitions of embryonic and fetal stem cells, To understand and review
the most fundamental genetic and epigenetic/transcriptional regulatory mechanisms guiding the
development of the essential organs, To understand and review the basic principles of regenerative
medicine and perinatal physiology.
Kursens innehåll : To achieve a better understanding of embryonic and fetal development, and to provide
better healthcare for newborns and children, it is necessary to understand the development in basic
research to be able to more rapidly apply such knowledge in clinical care. In this course, worldleading
scientists in the fields of developmental biology, stem cell research, and regenerative medicine, will discuss
the molecular mechanisms, cell biology, genetics and epigenetics of development in general and more
specifically in a wide variety of organs, with a particular bias towards human development and disease. The
nature of the course is translational and provide a wide range of knowledge from transcriptional
mechanisms to basic physiology and patient care.
Arbetsformer : The course is based on lectures from morning to lunch by prominent lecturers. There are
practical workshops and clinical visits in the afternoons. The course is considered demanding and requires
fulltime presence and attention.
Examination : Every student needs to make either a fifteen minute individual presentation or to present
their projects by poster presentation. The oral and poster presentations are examined by at least four
course leaders and the participants receive immediate feedback directly from the course leaders/examiners.
Further feedback is given continuously throughout the course. Every student will be individually assessed.
Obligatoriska moment : Full presence is absolutely required. Necessary absence will be regulated with
the course leader and given as extra tasks.
Övrig information : This is an international exchange course between Karolinska Institutet (KI) and
University of Toronto (U of T) on developmental and perinatal biology with a translational focus. It has been
organised since 1996 and now has over 500 alumni. It takes place every second year in Toronto and every
other second at KI, and 2015 it will take place at KI. In addition to lectures from 20 leading researchers in
the field from KI and Toronto, workshops, and "meet the expert" sessions, there is also an extensive social
program to allow the building of new contacts and interactions between the two universities. For 2015, this
program includes visits to the Canadian Embassy and City Hall of Stockholm. The course is also closely
linked to the Mats Sundin postdoc fellowship for exchange between KI and U of T. Please note that this is a
fulltime course.
Kursansvarig : Ola Hermanson
46852487477
Ola.Hermanson@ki.se
Kontaktpersoner : Ola Hermanson
46852487477
Ola.Hermanson@ki.se
Title : Introduction to Stata for epidemiologists
Kursnummer : 2796
Datum : 20150914 20150915
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After successfully completing this course you as a student should independently be
able to: use Stata to open and describe a dataset import and export datasets in different formats
produce tables of descriptive statistics count and present table of counts provide a graphical
presentation of continuous variables generate new variables and recode existing variables test
univariable associations for continuous and categorical data Kursens innehåll : This course is designed to introduce students to the basics of Stata. It will focus on the
minimum set of commands students should know to organize their own work. Specific topics include data
management, datareporting, graphics and basic use of dofiles. By the end of this course, the student
should be capable of using Stata independently. As motivating and instructive examples both lectures and
exercises will be based on real studies published in top scientific journals. Arbetsformer : Lectures and computer exercises using Stata®.
Examination : Written examination. Students who do not obtain a passing grade in the first examination
will be offered a second chance to resubmit the examination within two months of the final day of the
course. Students who do not obtain a passing grade at the first two examinations will be given top priority
for admission the next time the course is offered.
Obligatoriska moment : Examination is compulsory.
Urval av studenter : Selection according to 1) the relevance of the course for the applicant's project
Övrig information : The present course covers an introduction to the Stata package and basic commands
for data manipulation and presentation. The content on how Stata can be used to manage and analyse
epidemiological data is not covered.
Kursansvarig : Nicola Orsini
Nicola.Orsini@ki.se
Title : Biostatistics II: Logistic regression for epidemiologists
Kursnummer : 2797
Datum : 20151207 20151216
Språk : Engelska
Särskild behörighet : Knowledge in epidemiology and biostatistics equivalent to "Epidemiology I:
Introduction to epidemiology" (course 1577) and "Biostatistics I: Introduction for epidemiologists" (course
1579) or corresponding courses
Kursens lärandemål : After successfully completing this course you as a student are expected to be able
to: choose a suitable regression model for assessing a specific research hypothesis using data collected
from an epidemiological study, fit the model using standard statistical software, evaluate the fit of the
model, and interpret the results. explain the concept of confounding in epidemiological studies and
demonstrate how to control/adjust for confounding using statistical models. apply and interpret
appropriate statistical models for studying effect modification. critically evaluate the methodological
aspects (design and analysis) of a scientific article reporting an epidemiological study. Learning outcomes
are classified according to Bloom´s taxonomy: knowledge, comprehension, application, analysis, synthesis,
and evaluation.
Kursens innehåll : This course focuses on the application of linear and logistic regression in the analysis of
epidemiological studies. Topics covered include a brief introduction to continuous and binary outcome data,
univariable and multivariable models, interpretation of parameters for continuous and categorical
predictors, flexible modeling of quantitative predictors, confounding and interaction, model fitting and
model diagnostics. Arbetsformer : Lectures, computer lab with exercises focusing on analysis of real data sets using
statistical software, exercises not requiring statistical software, group discussions, literature review.
achieved. The course grade is based solely on a written examination. The focus of the exam will be on
understanding concepts and their application to analysis of epidemiological studies rather than
mathematical detail. The course examination will be held within one week of the final day of the course.
Students who do not obtain a passing grade in the first examination will be offered a second examination
within two months of the final day of the course. Students who do not obtain a passing grade at the first
two examinations will be given top priority for admission the next time the course is offered. If the course is
not offered during the following two academic terms then a third examination will be scheduled within 12
months of the final day of the course.
Obligatoriska moment : Examination.
Urval av studenter : Prerequisite knowledge equivalent to Epidemiology I and Biostatistics I or
corresponding courses. Eligible doctoral students will be prioritized according to 1) the relevance of the
course for their research, and 2) the stated motivation for attending the course. To be considered, please
submit a completed application form and give all information requested including a short description of
current research and motivation for attending, as well as an account of previous courses taken.
learning. The course will be given the following dates: December 7, 9, 11, 14, 16. Compared to the
previous version of this course, linear regression will be covered more and thus the number of higher
education credits is increased to 2.0 from 1.5.
Kursansvarig : Nicola Orsini
Nicola.Orsini@ki.se
Title : Människans Fysiologi en översikt
Kursnummer : 2827
Datum : 20151216 20160115
Språk : Svenska
Särskild behörighet : Kursens lärandemål : Studenten ska efter genomgången kurs ha översiktlig kunskap och förståelse för
hur människokroppens organsystem fungerar och samverkar under normala betingelser. Kursinnehållet ska
kunna användas för fortsatt fördjupning inom en forskarutbildning där vissa humanbiologiska kunskaper är
av värde. Färdigheter Skriftligt kunna redogöra för organsystemens funktion. Sammanställa och delge
information skriftligt för utvalda fördjupningsområden. Förhållningssätt och värderingsförmåga Uppvisa
ett kritiskt och vetenskapligt förhållningssätt till data som presenteras under föreläsningar och i
kurslitteratur. Kursens innehåll : Nervsystemets fysiologi Muskel Autonoma nervsystemet och endokrinologi
Högre hjärnfunktioner Hjärta och cirkulation Njure och syrabas Respiration Digestion Samt
samspelet mellan olika organsystem.
Arbetsformer : Kursen innehåller föreläsningar, gruppdiskussioner i form av frågestunder samt
problembaserad undervisning. Dessutom ges en frivillig dugga som ger bonuspoäng på tentamen.
Examination : För att bli godkänd i kursen måste studenten visa att lärandemålen har uppnåtts. Detta
bedöms genom en skriftlig tentamen. Obligatoriska moment : Moment som är obligatoriskt under kursen är tentamen. I anslutning till kursen
ges ett resttentamenstillfälle.
Urval av studenter : Urval av kursdeltagare baseras på 1) datum för doktorandregistrering (där tidigare
registreringsdatum har förtur) 2) kursplanens relevans för sökandes doktorandprojekt (enligt motivering). Övrig information : Bland föreläsarna kommer ni att träffa Håkan Westerblad och Bo Rydqvist.
Föreläsningarna ligger för det mesta på förmiddagarna. Kursansvarig : Hakan Westerblad
Hakan.Westerblad@ki.se
Title : Introduction to Quantile Regression and Related Methods
Kursnummer : 2833
Datum : 20151102 20151106
Språk : Engelska
Särskild behörighet : Biostatistics I or corresponding knowledge.
Kursens lärandemål : The main objective of this course is to introduce regression techniques for
analyzing data arising in epidemiology, environmental health, and other global health domains. After a brief
review of regression methods, the course will focus on quantile estimation. Statistical reasoning will be
emphasized through problem solving and applications. At the completion of this course, a student will be
able to: 1) Interpret commonly used statistics and regression methods; 2) When reading journal articles,
identify potential errors and limitations in the analyses; 3) Develop judgment about which statistical
technique to use in a given situation; and 4) Implement the described statistical techniques, including
estimation and hypothesis testing, using statistical software.
Kursens innehåll : Course Topics: The following is a tentative list of topics to be covered: 1. Descriptive
statistics ¿ measures of location and dispersion; empirical quantiles 2. Advantages of using quantiles.
Examples from the existing literature 3. The concept of regression. Examples of regression 4. Extending the
concept of quantiles to a regression framework 5. Quantile regression: examples and applications to real
datasets 6. Censored quantile regression: examples and applications to real datasets Arbetsformer : Laboratory Sessions: Lab sessions will take place every afternoon; they will be used to
review the material that was covered in the lectures and to work through additional problems and
computing issues. During these handson lab sessions, the students will have the opportunity to utilize the
methods presented in the morning lectures to the analysis of reallife data examples. Computing: This
course will provide an introduction to the R statistical package. R is free software and can be downloaded at
www.rproject.org. Full information about the usage of the software will be provided during the course. Any
student who has his or her own favorite statistical package is welcome to use it. The final exam does not
require the use of a computer.
Examination : Final assignment that assesses that all learning outcomes of the course are reached.
Övrig information : Kursansvarig : Matteo Bottai
08524 870 24
matteo.bottai@ki.se
Nobels väg 13
17177
Stockholm
Title : Philosophy of science and research ethics, statistics and
oral scientific communication
Kursnummer : 2839
Datum : 20150921 20151023
Språk : Engelska
Särskild behörighet : Kursens lärandemål : communicate own research well adjusted to different contexts by using various
means of communication based on theories of communication and learning assess the quality of peers'
communication of own research and give constructive feedback accordingly articulate considerations on
philosophy of science and research ethics in relation to the own research project be able to perform
basic summaries, analyses and presentation of data, as well as have enhanced their ability to recognize,
understand and critically view the statistics being presented in medical articles Kursens innehåll : Philosophy of science and research ethics 1.5 hp Oral communication techniques 3 hp Basic statistics 3 hp Arbetsformer : The pedagogic framing is based on student activity with interactive lectures, seminars and
workshops. The scheduled facetoface activities in the course will be mixed with individual work and
feedback from teachers and peers via the web based platform PingPong.
Examination : The knowledge, skills and attitudes acquired in the course will be assessed through written
assignments and oral presentations.
Obligatoriska moment : Assignments, seminar and group activities. Absence from seminar and group
activities can be compensated by self studies and written assignments.
Urval av studenter : The selection for this general science course will be based on your admission date to
doctoral education (priority given to earlier registration date). Please make sure that you have entered the
correct registration date for doctoral education in your personal profile. Övrig information : The content and focus of course 2839 is equivalent to the three independent courses
2144 "To communicate science in different contexts", 1386 "Ethics and Philosophy of Science" and
1383/2609 "Basic Course in Medical Statistics". It is required that students have not attended any of these
courses previously (or their equivalent). Transfer of credits from previously attended courses will not be
approved/possible. This is a five week course which requires time for independent work outside of
scheduled class time. Scheduled class room sessions are on the following dates: 2125 September, 28
September2 October, 59 October, 1216 October and 1923 October. The course is given in ENGLISH. Kursansvarig : Cormac Mcgrath
Kontaktpersoner :
Title : The third dimension of nuclear functions
Kursnummer : 2841
Datum : 20151012 20151016
Språk : Engelska
Särskild behörighet : ingen särskild behörighet efterfrågas
Kursens lärandemål : Following the completion of the course the students will be able to describe the
basic principles of 3D genome organisation and how this relates to nuclear functions such as transcription,
replication, DNA repair and telomere maintenance. The students will also be able to design experiments for
studying the 3D structure of chromatin, compartmentalisation of nuclear functions in the nuclear space and
to critically evaluate results obtained with these techniques.
Kursens innehåll : The course covers the basic principles of genome regulation in 3D and how marks of
the primary chromatin fibre relate to the 3D structure of chromatin. Particular attention will be paid to the
regulation the nuclear architecture during development, and its role in lineage specification by means of
coordination of transcription and replication in space and time. Speakers will include the course organizers
and several wellknown international researchers dedicated to research on relevant aspects of chromatin.
Arbetsformer : The learning activities used in the course include lectures, research seminars and research
article presentation by the students. Each student will present a recent publication in the form of a journal
club. Students will also be encouraged to actively participate in the course. There will be substantial time
for discussions after the lectures and research seminars.
Examination : Examination is based on the journal club presentation and a written test. Every student will
present a preselected article, and will be the opponent for the presentation of a fellow student. The
student's performance at these two occasions combined with the test results will be the basis for the final
assessment.
Obligatoriska moment : The lectures, seminars and journal club presentations are compulsory.
Compensation according to the instructions of the course director.
Övrig information : This is a 5day (Monday to Friday) fulltime doctoral course offered by the
'Tumorbiology/Oncology doctoral programme'. The course will take place at the Department of
Microbiology, Tumor and Cell Biology. Kursansvarig : Anita Göndör
08 524 862 03
anita.gondor@ki.se
Kontaktpersoner : Anita Göndör
08 524 862 03
anita.gondor@ki.se
Title : The cell cycle
Kursnummer : 2843
Datum : 20151116 20151120
Språk : Engelska
Särskild behörighet : Kursens lärandemål : Upon completion of the course the students should: Be able to explain the key
aspects of the cell cycle Show uptodate knowledge on the molecular mechanisms that regulate the cell
cycle. Explain the relevance of the cell cycle for health and disease. Understand and discuss diverse
pharmacological strategies targeting the cell cycle. Critically evaluate different experimental models and
technologies used in cell cycle research Be familiar with stateofthe art methodologies used for studies in
cell cycle Be capable of designing experiments for studies on cell cycle Be able to relate the contents of
the course to their specific projects and field of research Present and discuss the most recent findings in
cell cycle research Kursens innehåll : The course will cover key aspects of cell cycle, including cell cycle control, DNA
replication, chromosome segregation, checkpoints, mitosis and asymmetric cell division. During the course,
we will openly and critically discuss the latest research advances in a broad spectrum of experimental
organisms. The course will have a special focus on the molecular events that regulate the cell cycle and
their relevance for human diseases, such as developmental disorders and cancer.
Arbetsformer : The teaching modes will consist of lectures and research seminars by invited speakers,
including time for discussions with each speaker. In addition, the students will work in groups, with a
guiding tutor, to critically review original articles that are relevant to the content of the course, with specific
focus on the background, the technologies and experimental models used and the significance and
implication of the findings. Finally, the students will work on teams to prepare posters that summarise the
most important 'takehome messages' of the course and putting them in the context of their own research
activities. The original papers and the posters will be presented in a minisymposium that will take place the
last day of the course. Examination : Each student will be examined by his/her individual journal club presentation and his/her
contribution to the poster session that will take place during the minisymposium. All learning outcomes will
be assessed.
Obligatoriska moment : Attendance to the lectures, research seminars, journal clubs and mini
symposium are compulsory. Compensation could be done according to the instructions of the course
director. Antal studenter : 15 20
Övrig information : 'The cell cycle' is a 5day (Monday to Friday) fulltime doctoral course offered by the
'Developmental biology and cellular signalling doctoral programme'. The course will take place at the
Bioscience and Nutrition department (South Campus, Huddinge). Kursansvarig : Victoria Menendez Benito
victoria.menendez.benito@ki.se
Kontaktpersoner :
Title : Exploring entrepreneurial opportunities in research
Kursnummer : 2844
Datum : 20151116 20151120
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course, a doctoral student shall be able to; demonstrate an
understanding of the opportunities of innovation, entrepreneurship and utilization, use basic business tools
in their own research project, assess their new skills and reflect on the possible future effects (individual,
organization or society).
Kursens innehåll : The course aims to increase the awareness of the potential of innovation and
entrepreneurship. It begins with an introduction to entrepreneurship, what it is and how it can be used in
the doctoral education. The doctoral students are then given a number of practical business tools to use in a
minor innovation projects based on their own research.
Arbetsformer : The course runs over five full days, including two days of training and three days of own
work. Learning activities consist of seminars and workshops as well as group and individual work. With the
individual assignments the doctoral students are given the opportunity to take a closer look at the actual
benefits of the new knowledge and put it into a larger context, with value for their own research.
Examination : The doctoral students are examined by a written individual assignment and design of a
poster. In the written assignment the doctoral student describes what they learned, how it can be utilised in
their own research and reflect on the effects for the future. The poster describes a concrete example of
application of the new knowledge in their own research project.
Obligatoriska moment : Attendance is mandatory. The course director assesses if and in that case how
absence can be compensated.
Övrig information : The course will be given at KI Campus in Solna, in collaboration with the actors of the
local innovation system.
Kursansvarig : Hanna Jansson
0852483861
hanna.jansson@ki.se
Kontaktpersoner :
Title : Cellbased heart regeneration
Kursnummer : 2845
Datum : 20150928 20151002
Språk : Engelska
Särskild behörighet : Kursens lärandemål : Upon completion of the course, the doctoral students will be able to describe
important principles in studying the development of the human heart, relate these to heart disease, and
critically evaluate important methods and technologies applied in the context of regenerative medicine for
heart disease. Kursens innehåll : The developmental principles, logic, pathways, technology, and model systems to
unravel human heart disease. Regenerative cardiology, bioartificial heart tissues and translational bench to
bedside regenerative medicine. Arbetsformer : The learning modes used in the course include lectures, discussions, seminars and a one
day research symposium. Examination : The students are examined with individual and group presentations on the course themes. Obligatoriska moment : Participation in the group discussions and student presentations is mandatory.
Compensation is according to the instructions of the course director.
Övrig information : The course is jointly organized by SCRMC/Emerging Strategic Research Theme on
Stem Cell at Hong Kong University and DBRM Research School (www.dbrm.se) at KI. The course takes
place at CMB, seminar room A216, Berzelius v 35 in Solna. One day of the course is organized in the form
of a research symposium at Nobel Forum. Kursansvarig : Matti Nikkola
Matti.Nikkola@ki.se
Kontaktpersoner :
Title : Integration of Neuroimaging and Cognition in Normal
Aging and Dementia
Kursnummer : 2846
Datum : 20151109 20151113
Språk : Engelska
Särskild behörighet : Previous knowledge in cognitive processes, brain anatomy and neuroimaging is a
requirement.
Kursens lärandemål : After attending the course, the graduate student will be able to (1) describe and
differentiate neural and cognitive profiles that accompany normal aging and different types of dementia (2)
select the most appropriate methods in order to address scientific questions pertaining to neural correlates
of cognitive functions, (3) identify, combine and test different risk factors for dementia (genetic, biological,
environmental) on brain integrity and cognition, (4) compute analyses in the most commonly used
neuroimaging softwares (e.g., SPM, Freesurfer). Kursens innehåll : This course focuses on the study of the neural bases of cognitive decline in normal
aging and dementia. The main neuroimaging methods included in this course are: Structural MRI (including
volumetry and DTI), functional MRI, molecular PET and MRI (neurotransmission (e.g., dopamine) and
markers of Alzheimer's disease amyloidbeta, iron). Each day of the course constitutes a specific subtopic.
Day 1 is about "the essentials" on dementia, cognitive trajectories and neural changes in normal aging and
dementia. On Days 2 and 3, cognitive and neuroimaging data will be integrated (day 2: structural and
functional MRI; day 3: molecular neuroimaging PET/MRI, and multimodal and multivariate imaging). On
Day 4, genetic, biological and environmental modifiers of cognition and neural integrity are considered. On
Day 5, an introduction to cognitive and brain plasticity in aging is provided. Arbetsformer : The course contains: (1) short lectures that provide uptodate knowledge about the brain
correlates of cognitive decline in normal aging and dementia, (2) seminars where methods linking
neuroimaging and cognitive data are discussed based on the literature, (3) handson sessions where the
students compute analyses on real data. Each subtopic (e.g., atrophy and cognition in normal aging and
dementia) includes one lecture with relevant literature, a seminar on the methods used to address the
question of interest and/or handson implementing the methods on real data. Examination : The students will be evaluated on group presentations during seminars and on an individual
written examination consisting of a 2page essay describing how the student can test his/her hypotheses
related to his/her thesis based on the knowledge and methods acquired during the course. After the end of
the course, one week is given to allow the students to send the essay.
Obligatoriska moment : All parts of the course are compulsory. Absence is compensated for by a written
assignment.
Urval av studenter : We welcome students from different academic backgrounds (master in psychology,
neuroscience, medicine, biology, engineering, neuroepidemiology). Students with specific backgrounds such
as cognitive psychology and neuroscience will be prioritized. Selection will be based on 1) the relevance of
the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for
registration as a doctoral student (priority given to earlier registration date).
Övrig information : The course is held during 5 consecutive days (MondayFriday) from ca 9.00 to 16.00
(with breaks). Address: Aging Research Center (ARC), Gävlegatan 16, 113 30 Stockholm.
Kursansvarig : Grégoria Kalpouzos
gregoria.kalpouzos@ki.se
Kontaktpersoner : Alireza Salami
alireza.salami@ki.se
Francesca Mangialasche
Francesca.Mangialasche@ki.se
Title : Cancer and cancer stem cells
Kursnummer : 2849
Datum : 20151116 20151120
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After completion of the course, the student will be able to describe the concept of
cancer stem cells, the relationship between cancer and cancer stem cells, as well as assays to identify these
stem cells. Within this framework, the student will be able to demonstrate an understanding for the
development of cancer in the context of solid tumors and leukemia. In addition, the students will be able to
critically evaluate the advantages and drawbacks of basic mechanisms employed for cancer treatment in
the clinic. Kursens innehåll : The course covers key principles of cancer development and cancer therapies, and
provides an appreciation for the concept of cancer stem cells and its implications from a clinical and basic
science perspective. This includes a general overview of molecular and cellular mechanisms underlying
cancer development, drug resistance, disease relapse, cancer stem cells, therapeutic stem cell
transplantation and clinical care for the treatment of solid tumors and leukemia, immunological cancer
related considerations, and perspectives for novel cancer therapies. The student will be required to take an
active part in this course by contributing with presentations and discussions related to cancer and cancer
stem cells.
Arbetsformer : The pedagogic frame of this course is based on lectures combined with topicrelated
research articles. The course includes workshops where the students are required to present articles,
integrate the knowledge acquired from lectures and reading of the articles, and actively discuss their
acquired knowledge as a group. Each student will research, prepare and present his or her examination task
orally.
Examination : The individual performance of each student will be evaluated separately based on their
presentation of a cancer stem cellrelated topic and the feedback the students provide to their fellow
students. The content and organization of the presentation and discussion will follow a format provided by
the instructors.
Obligatoriska moment : The lectures and discussions are mandatory. Absence is compensated according
to the instructions of the course director.
Urval av studenter : The selection process will be based on a comprehensive assessment of the
applicants, including students and postdoctoral researchers: 1. Motivation for the course 2. Topic of their
PhD project 3. Years since PhD registration (priority will be given to earlier registration date) Övrig information : The course is organised by the Department of Medicine, KI Solna and the Center for
Hematology and Regenerative Medicine, KI Huddinge. The course sessions will take place at KI Solna and KI
Huddinge campuses. There will be a course lunch during the course week. Kursansvarig : Natalia Landazuri
natalia.landazuri@ki.se
Kontaktpersoner : Hong Qian
hong.qian@ki.se
Natalia Landazuri
natalia.landazuri@ki.se
Title : Initiating entrepreneurial thinking in connection to
research
Kursnummer : 2852
Datum : 20150914 20151218
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course, a doctoral student shall be able to; describe selected business
tools for e.g. needs assessment, ideation, market analysis and business modelling, understand the
qualities and challenges with interdisciplinary team work, assess their new skills and reflect on the
implementation in research and development.
Kursens innehåll : Entrepreneurship courses give their participants tools to come up with ideas, plan and
carry out projects. These courses also increase the participants knowledge of what happens outside their
own academic context. This course contains a selection of lectures from courses within everything from
ideation and design to startup and business modelling. Each course is unique in that the participating
doctoral student selects six (6) lectures from a sample of the courses offered within the framework of the
Stockholm School of Entrepreneurship (SSES).
Arbetsformer : The course is offered in evenings and parttime over one semester. The doctoral student
selects, in discussion with the course director, at the beginning of the course six (6) lectures to attend.
Learning activities consist of these lectures (and/or seminars), an online individual learning log and an
individual reflection. With the individual assignments the doctoral student is given the opportunity to take a
closer look at the actual benefits of the new knowledge and put it into a larger context, and value for their
own research.
Examination : The doctoral students are examined by an individual learning log and an individual
assignment. In the assignment the doctoral student describes what they learned, how it can be utilised in
their own research and reflect on the effects of the new knowledge.
Obligatoriska moment : Attendance at six (6) selected lectures is mandatory. The course director
assesses if and in that case how absence from compulsory parts can be compensated.
Övrig information : The course is given by KI but individual lectures/seminars will be held at the Royal
Institute of Technology (KTH), Stockholm School of Economics (SSE), Stockholm University (SU) and/or the
University College of Arts, Crafts and Design (Konstfack). Find out more about the different topics/courses
that will form the basis for this course at www.sses.se. The course can be completed in a shorter time
period depending on individual interest.
Kursansvarig : Hanna Jansson
0852483861
hanna.jansson@ki.se
Kontaktpersoner :
Title : Translational lung cancer research
Kursnummer : 2854
Datum : 20151021 20151022
Språk : Engelska
Särskild behörighet : Kursens lärandemål : At the end of the course the student is expected to: Understand lung cancer
tissue processing for biobanking, and extraction of DNA, RNA and proteins Know how to apply molecular
techniques on clinical lung cancer tissue samples Have basic knowledge about lung cancer pathology Be
oriented about the frontlines of genomic, transcriptomic and proteomic lung cancer research Understand
standard and targeted therapy concepts for lung cancer, and coupled biomarker research and diagnostics. Kursens innehåll : The course aims to convey a basic understanding of how modern high throughput
molecular analyses can be applied to clinical lung cancer tissue, with regard to opportunities and limitations
imposed by diagnostic sampling and tissue processing. The students will be introduced to basic diagnostic
algorithms, treatment strategies, cancer histopathology and molecular diagnostics, as well as to exploratory
translational research in lung cancer genomics, transcriptomics and proteomics. A final goal is that the
students shall be able to formulate a translational project related to their own research interest.
Arbetsformer : The course will be organized as a one day lecture/seminar module (in Stockholm), followed
by a second day with microscopy seminars and visits/introductions to pathology laboratory units for tissue
processing, biobanking and molecular diagnostics (in Uppsala). As a basic learning process we emphasize
informal critical dialectic constructive discussions throughout the course ("Filip och Fredrik pedagogic"). The
students will be provided before the starting of the course with material that they should read in advance
and that will be used as base for the lectures and discussions during the course days.
Examination : To pass the course the students must show that they have reached the learning outcomes
of the course. This will be assessed formatively during the two days "on site" and by writing a potential
translational lung cancer project related to their own research interests afterwards.
Obligatoriska moment : Full attendance during the two days "on site" module is compulsory.
Urval av studenter : Selection of students will be based on personal motivation and the relevance of the
course content for their research. Priority will be given to register doctoral students at KI and Uppsala
University. If necessary, a further selection will be based on the date for registration as a doctoral student.
Övrig information : The course is organised in two days. The first day, organised as lecture/seminar
module, will take place at the Dept of Cell and Molecular Biology (CMB) Karolinska Institutet, Stockholm.
The second day, with microscopy seminars and visits/introductions to pathology laboratory units for tissue
processing, biobanking and molecular diagnostic, will be held at the Department of Pathology, Rudbeck
laboratory, Uppsala University Hospital. Course directors Johan Botling johan.botling@igp.uu.se Patrick
Micke patrick.micke@igp.uu.se Course coordinator: Teresa Frisan teresa.frisan@ki.se
Kursansvarig : Teresa Frisan
0852486385
Teresa.Frisan@ki.se
Berzelius väg 35
S17177
Stockholm
Kontaktpersoner :
Title : Digital photomicrography
Kursnummer : 2855
Datum : 20151019 20151023
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After completing the course, the participants will have a working knowledge of the
fundamentals of optical microscopy and be able to use appropriate presentation methods for conveying
their research results in a clear and informative way. Multimedia software and image processing software
will be used including Adobe Photoshop® as well other digital microscopy software for image acquisition.
Kursens innehåll : The course will include theory and practice investigating conventionallight microscopy,
dark field, ultraviolet fluorescence, phase contrast and interference (DIC). Additionally, the course will
dedicate one day to confocal microscopy and the Analysis and Measurement of Data through theoretical and
practical sessions. Following the mastery of microscopy, the course explores fundamentals of digital
photography. The participants will be exposed to digital cameras and their proper operation. There is an
overview of video and still digital cameras relative to application needs. Relevant issues such as capture,
processing, transmission and storage concerns are explored. Participants will work individually with popular
image editing softwares such as Adobe Photoshop® as well as other imaging softwares. Exercises have
been created to develop image processing imperatives such as file resolution and type, adjusting of tones
and contrast, and composition. Arbetsformer : The course will consist of lectures and practical micrography laborations.
Examination : Each student's knowledge will be assesed through an oral examination during a practical
microscopy laboration.
Obligatoriska moment : Practical micrography sessions are compulsory, as is an overall attendance of
100%. Absence can be compensated for by completing extra work as agreed with the course organizer.
Övrig information : This course has a strong theoretical and handson component evenly distributed over
the five days and will run from 8:3017:00 Monday Friday in lecture room Bi515, floor 5, KTH/Teknik och
Hälsa, (Bipontus) Alfred Nobels Allé 10 at KTH Huddinge University Campus. The workshop explores in good
depth fundamentals of bright field microscopy, as well as various other microscopy techniques such as
fluorescence and phase. A significant amount of content is also dedicated to electronic imaging and image
processing using Adobe Photoshop®. This is an approved PhD course, number HL201U at KTH Royal
Institute of Technology, and 2855 at Karolinska Institutet, and has a credit value of 1.5 point. The course is
run in conjunction with contract education for external participants. The number of participants is limited to
18. Kursansvarig : Moustapha Hassan
08585 838 62
Moustapha.Hassan@ki.se
Kontaktpersoner : Jennifer Usterud
08585 832 38
jennifer.usterud@ki.se
Title : Teaching and Learning in Higher Education: educational
course for doctoral students a distance course
Kursnummer : 2856
Datum : 20150911 20151217
Språk : Engelska
Särskild behörighet : Kursens lärandemål : At the end of the course, students are expected to: Be familiar with different
roles of a professional university teacher and current conditions related to teachinglearning within higher
education. Be able to use educational concepts in discussions of teaching and learning situated in Higher
Education. Design teaching in regards to outcome or competency based frameworks for curriculum
design and also in relation to theories of learning or research on student learning in higher education. Kursens innehåll : Roles and conditions related to being a professional university teacher. Students
learning in higher education Different forms of teaching and learning activities Design of teaching for
learning Arbetsformer : The course is based on theories of experiential learning, a reflective attitude and learning
through participation and collaboration. Teaching is conducted via the learning platform Ping Pong and is
constructed largely around the students' own reading of literature, written assignments, peer feedback and
online group discussions. The majority of assignments are based on the students describing, examining
and reflecting over their own teaching and relating this to literature/theory.
Examination : In a final examination assignment, the participant apply course content in reviewing and
discussing development of one a teaching situation related to their own practice. This is presented through
a written essay. To pass the course, the participant is required to: Complete all module assignments and
participate actively in group work and discussions online during the course Conduct the assignment of
being a "critical friend"; observing and giving feedback on a colleagues teaching. Giving feedback to a
peers´ examination assignment Pass the final examination assignment, which is judged using assessment
criteria. Obligatoriska moment : Participation in group discussions online Doing the examination assignment
Provide peer feedback on course and examination assignments. Antal studenter : 5 7
Urval av studenter : Priority will be given to students with planned teaching included in their individual
study plan. Enter a brief motivation and indicate the area within which the teaching is to be given.
Secondly, selection will be based on registration date as a doctoral student. Please make sure that you have
entered the correct registration date for doctoral education in your personal profile.
Övrig information : The course aims to prepare students for teaching in higher education and contribute
to the professional development as teacher. The course is a distance course and teaching is conducted via
the learning platform Ping Pong and is constructed largely around the students' own reading of literature,
written assignments, peer feedback and online group discussions. The course is given in English.
Kursansvarig : Cormac Mcgrath
08524 837 89
Title : Orientation in qualitative research methods
Kursnummer : 2857
Datum : 20151105 20151119
Språk : Engelska
Kursansvarig institution : Department of Public Health Sciences
Kursens lärandemål : At the end of the course the students should be able to: understand and explain
the theoretical basis for the main qualitative methods understand and explain the main differences
between qualitative and quantitave research know the main qualitative research methods (content
analysis, phenomenography, grounded theory, narrative analysis, discourse analysis), understand the
differences between them and know how to choose the method most adequate for the research question at
hand plan and carry out a qualitative research interview, a focus group discussion and an observation
session, including know how to handle the information gathered and analyse the data understand the
ethical aspects of qualitative research and how to handle them in a professional way explain how the
validity/quality is assessed in qualitative research prepare the outline of an article based on data collected
during the course Kursens innehåll : Theoretical basis for qualitative research The main qualitative research methods
(participant selection, data collection, handling of data, analysis) Validity/quality assessment of qualitative
research Ethics in qualitative research Reading and writing qualitative research Arbetsformer : Lectures Group work Practising observations, interviewing and moderating focus
group discussions Practising handling of qualitative data by hand and using software Practising how to
analyse qualitative data and writing it up Seminars to discuss the experiences from the practical sessions Examination : an individual written examination to assess aquired knowledge and understanding of
qualitative research assessment of the practical assignments and how the experiences are presented in
the seminars the drafts for an article based on the data collected in the practical assignments to assess
the understanding of the process and ablity to analyse data and condense information Obligatoriska moment : Practical assignments are compulsory and have to be carried out during the
course. This cannot be compensated for.
Övrig information : The course meets inperson on three consecutive Thursdays, 5 November, 12
November and 19 November; with practical assignments outside of course
Kursansvarig : Rachel Irwin
Institutionen för folkhälsovetenskap
rachel.irwin@ki.se
Kontaktpersoner :
Title : Longitudinal data analysis classical and modern
statistical methods
Kursnummer : 2858
Datum : 20151102 20151113
Språk : Engelska
Särskild behörighet : Basic medical statistics
Kursens lärandemål : After successful completion of the course the student will be able to: 1. Understand
the underlying characteristics of longitudinal data 2. Identify appropriate tests for longitudinal studies 3.
Manage longitudinal datasets and prepare these for statistical analysis using statistical software program
SPSS 4. Apply both simple and complex statistical methods of longitudinal data 5. Use SPSS to perform the
above mentioned statistical analysis 6. Present and interpret the results of analysis Kursens innehåll : The aim of the course is to introduce statistical models and methods for the analysis of
longitudinal data and to develop statistical skills of analyzing correlated data. The main focus will be on
frequently used statistical methods and how these should be used to provide more insight concerning
research questions in longitudinal studies. Thus the course covers both classical and modern methods to
analyze longitudinal data. Topics include Univariate repeated measures analysis of variance, Multivariate
repeated measures analysis of variance, Drawbacks and limitations of classical methods; General linear
models for longitudinal data; Linear mixed effects models; Non linear longitudinal data models and handling
missing data. The underlying mathematical theory will not be stressed, and the main focus will be on
concepts and applications.
Arbetsformer : Teaching methods include lectures, computer based exercise and seminars 34 scheduled
days during two weeks. Participants will have access to materials from a number of studies and are given
the opportunity to use the statistical software program, SPSS during practice sessions. In addition, you will
have seminars, group discussion and presentations. Examination : Assessment of the intended learning outcomes by the computer based exercises (should all
be approved) and the final seminar. Obligatoriska moment : Computer based exercises, seminars, presentations and some lectures are
mandatory. The course leader assesses whether and if so, how absence can be compensated.
given to earlier registration date) Övrig information : The course will consist of four scheduled whole days per week for two weeks. Course
dates: 2 3/11, 5 6/11, 9 10/11, 12 13/11; 2015 Kursansvarig : Mesfin Tessma
Mesfin.Tessma@ki.se
52487118
Title : DNA damage and maintenance of genome integrity
Kursnummer : 2859
Datum : 20151012 20151016
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the course, the student shall be able to: Regarding knowledge and
understanding, describe how exposure to various environmental agents and anticancer drugs can lead to
modifications of DNA account for various types of DNA damage and how they can be analyzed, as well as
the molecular mechanisms by which cells detect, signal, and repair DNA damage to maintain the integrity of
the genome describe epigenetic mechanisms in relation to genome instability account for the
connections between DNA damage/DNA repair capacity and human disease, particularly cancer Regarding
skills and ability, plan and perform one established method used for studying genotoxic effects such as
comet assay, micronuclei assay or gammaH2AXstaining Regarding judgment and approach, evaluate
their own results and critically assess research papers relevant to the field of DNA damage, DNA repair and
genome instability. Kursens innehåll : Drugs and many environmental pollutants such as airborne particles, hydrocarbons,
metals, manufactured nanoparticles as well as different mixtures may affect the genome integrity by
causing changes in the genome or epigenome. Effective maintenance and interpretation of the genome is
essential for normal cell division, tissue homeostasis, and cellular and organismal fitness. DNA damage and
errors in DNA replication, recombination and repair, and epigenetic mechanisms all contribute to genomic
instability and tumor progression. The course focuses on the formation of DNA damage as well as molecular
mechanisms devoted to the preservation of genome integrity in eukaryotic cells. Topics include DNA
damage formation and analysis, DNA damage recognition and repair pathways, cell cycle checkpoint
mechanisms, and DNA repair as target for therapeutic intervention. The course emphasizes the relevance of
these mechanisms in human disease development. The course also includes a practical part in which the
students perform one selected assay for assessing DNA damage following cellular exposure to a substance
of interest for the student. The course builds on a strong core of researchers with expertise in multiple
aspects of genome biology across a broad range of research areas including Toxicology, Cancer biology, and
Molecular Biology research.
Arbetsformer : The teaching includes lectures, seminars, laboratory sessions, oral presentations and group
assignments.
Examination : The students will present in an oral form their laboratory group work and demonstrate their
skills in discussing their own work and the work presented by their fellow students. Obligatoriska moment : Participation in the laboratory sessions is mandatory. Absence can be
compensated with an individual task.
Övrig information : Kursansvarig : Kristian Dreij
08524 875 66
Kristian.Dreij@ki.se
Nobels väg 13
17177
Stockholm
Title : Extracellular vesicles: a tool for diagnostics and therapy.
Kursnummer : 2860
Datum : 20151109 20151113
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After the completed course, the student will be able to describe the basics of
extracellular vesicles (EV) biology and function as well as a number of novel technologies and approaches in
EV isolation and characterization. The student can demonstrate an interdisciplinary understanding of central
concepts in EV biology and critically evaluate different methods and techniques used. The student will be
able to extract and integrate information from stateoftheart lectures in combination with overview
articles and literature searches on the internet within the research field. Kursens innehåll : The course covers key concepts in EV biology and function from the laboratory to the
patient in the clinic. This includes a general overview of EV isolation and characterization approaches, tools
as diagnostics and prognostics of various diseases and the possible use of EVs in therapy. Experts will give
an advanced summary of the latest events in the EVfield. The student will be required to take an active
part, contribute and value discussions in workshops on relevant topics in the EVfield. Networking with
students and speakers is highly encouraged in this course. Arbetsformer : The pedagogic framing of this course is based on lectures with corresponding review
take an active part in the discussions. Group discussions and workshops will be conducted where the
students discuss and integrate information from the lectures and review papers. The students prepare and
present their examination task in a written report that is handed in after the course.
Examination : An individual written project report consisting of 2 A4 pages covering one of three topics
provided by the course leaders is expected to be handed in after the course. The last date to hand in the
report is 1 week after the last day of lectures on the course. The written report will be evaluated on the
understanding of central concepts in EV biology and integration of discussions from the course and provided
course literature.
Obligatoriska moment : The lectures, workshops and discussions are mandatory. Compensation
according to the instructions of the course director.
given to earlier registration date). Post docs and master students are welcome to apply and will be
accommodated if spaces are available. Övrig information : The course covers key concepts in EV biology and function from the labratory to the
patient in the clinic. Invited speakers represent world leading scientists in the field including Professor
Matthew JA Wood from the Department of Physiology, Anatomy and Genetics at University of Oxford. Prof.
Wood is a worldleading scientist in developing RNAbased therapies for neurological diseases. He has
developed systems for creating engineered exosomes which can target specific molecules to the brain,
which paves the way for generating targetspecific exosomebased therapies. The course including lectures,
workshops and discussions will be scheduled full time from Monday to Friday in "Cellen", Hälsovägen 79,
Novum Huddinge. Time to prepare the individual examinations will be given during two days the following
week. Kursansvarig : Nina Heldring
0700626390
Nina.Heldring@ki.se
Karolinska Institutet HERM, Novum
14157
Huddinge
Kontaktpersoner : Samir ElAndaloussi
Samir.ElAndaloussi@ki.se
Title : Biomedical Ecology The microbiota in health and disease
Kursnummer : 2861
Datum : 20151123 20151127
Språk : Engelska
Särskild behörighet : Kursens lärandemål : After finishing the course the student should be able to show knowledge about:
the composition and function of the intestinal microbiota and its cross talk with the host. the establishment
of the microbiota during different stages of life, and its impact on the development and function of the
immune system and host tissues. the role of how an altered intestinal function and dysbiosis might occur
in connection with different diseases/disturbances. The student should be able to show insight in:
methods to study the intestinal microbiota as well as data analyses and interpretation. the microbiota as
the largest metabolic organ in the body and its physiological and pathophysiological role in health and
disease. the role of the hostmicroflora crosstalk for the intestinal ecology/homeostasis. Kursens innehåll : The course will cover the aspects of the composition and function of the intestinal
microbiota from birth, during life and the ageing period, how it might be influenced by diet and disease, and
hostmicrobe crosstalk. Sequencing techniques will be introduced for the study the microflora and compared
to biochemical methods. Novel findings will be discussed by lecturers in the research frontline on the
translational topics of normal flora in relation to inflammatory bowels diseases (IBD), irritable bowels
syndrome (IBS) celiac disease, reumatological and neurophysiological diseases. The course will be suitable
for clinical and preclinical PhD students and researchers where the microbiota is of significance, including
areas such as allergy, asthma, systemic autoimmune diseases, cardiovascular diseases, obesity,
rheumatology, neurophysiological disturbances such as autism spectrum disorders, chronic fatigue, nutrition
including effects of pre and probiotics, diabetes, metabolic syndrome, infectious diseases and
bioinformatics. The course replaces the previous course 2300. Arbetsformer : The course will combine lectures, student work shops and student seminars, and practical
laboratory work lectures by well established frontline researchers in their respective fields. laboratory
experiments on the students own intestinal flora. work shops/combined with focused literature studies
within defined areas which will be summarized in terms of student seminars. flipped class room and peer
learning using the competence of the course attendees. Examination : Summative examination includes laboratory work and student presentations that are
evaluated by the respective tutor at the specific course module and written examination of the course
content by multiplechoice questions covering all topics discussed. Obligatoriska moment : Laboratory work and student workshops and seminars. Participants that are
absent from the laboratory part and seminars will have to present a written paper on the subject. Antal studenter : 12 24
Urval av studenter : Selection will be based on the relevance of the course syllabus for the applicant's
doctoral project (according to written motivation). Övrig information : Kursansvarig : Åsa Sjöling
08524 875 04
asa.sjoling@ki.se
Kontaktpersoner : Katrin Pütsep
Katrin.Putsep@ki.se
Title : Regulatory RNAs in Development, Disease and Evolution
Kursnummer : 2865
Datum : 20151007 20151016
Språk : Engelska
Kursansvarig institution : Department of Medical Biochemistry and Biophysics
Särskild behörighet :
Kursens lärandemål : After completing the course, the students should be able to: describe the
different kinds of regulatory RNAs in development, disease and evolution, and their mechanism of action
describe and critically evaluate the application of emerging experimental strategies for the study of
regulatory RNAs transfer the knowledge acquired in the course into their specific projects and fields of
research. Kursens innehåll : The course will cover key concepts concerning regulatory RNAs and their mechanisms
of action. The following themes will be covered: Different kinds of regulatory (noncoding) RNAs in
eukaryotes, regulatory RNAs in development and disease, regulatory RNAs in virus and bacteria, evolution
of regulatory RNAs, RNA dynamics and RNA methodologies (bioinformatics and emerging experimental
strategies). Arbetsformer : The learning activities include lectures, seminars, group discussions and presentations. The
students will present themselves with short chalk talks on the first day. They will be divided into groups and
will have several sessions designated for groups discussions and brainstorming to transfer and apply the
new knowledge acquired during the course into their specific projects and fields of research. Each group will
present and discuss their conclusions from these discussions to all the other students and course directors.
Examination : Examination according to the intended learning outcomes of the course will take place in
form of a presentation, where the course participants will discuss the transfer of the knowledge acquired
during the course into their specific projects and fields of research. Each course participant will be assessed
individually. Obligatoriska moment : Lectures, seminars, group discussions and presentations are mandatory.
Compensation in case of absence according to the instructions of the course director.
Urval av studenter : The selection is based on relevance of the course content for their doctoral project
and the personal motivation included in the course application.
Övrig information : The course is full time. Most of the course lectures will be given at the main seminar
room at the Scheele building, Department of Medical Biochemistry and Biophysics (A3 311). The students
will participate in a Karolinska Institutet conference on Regulatory RNAs and Chromatin at the Nobel Forum,
October 16th 2015, with the following speakers confirmed: Leonie Ringrose, Institute of Molecular
Biotechnology, Vienna, Austria, Johan Jakobsson, Lund University, John Rinn, Harvard University, USA,
Raffaella Santoro, University of Zurich, Switzerland, Marcel Dinger, Garvan Institute of Medical Research,
Sidney, Australia and Tony Kouzarides, University of Cambridge, United Kingdom. The course is jointly
organized by Karolinska Institutet and Uppsala University and cofunded by the doctoral programme in
Regenerative medicine, doctoral programme in Cell Biology and Genetics (see
https://internwebben.ki.se/en/doctoralprogrammes0) and DBRM (www.dbrm.se). This course has
previously been given as a one week course (1,5 hp), course number 2698.
Kursansvarig : Goncalo CasteloBranco
Goncalo.CasteloBranco@ki.se
Kontaktpersoner :

Katalog kurser på forskarnivå HT15

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