IMA IN THE PHARMACEUTICAL

IMA IN THE PHARMACEUTICAL AND COSMETIC INDUSTRIES
IMA IN THE PHARMACEUTICAL
AND COSMETIC INDUSTRIES
www.ima.it
IMA AT YOUR SIDE SUPPORTING YOU WITH INNOVATION
Innovation is ensured through across the board levels of excellence. Such innovation for
designers and manufacturers of automatic processing and packaging machinery starts with
a long process involving the most thorough research. The chances of success are good when
such a process actively involves the final user. This is why the best approach to innovation is
to start with a constructive spirit of collaboration between the supplier and the customer.
Founded in 1961, IMA is the world leader in the manufacture of automatic machines for the
processing and packaging of pharmaceutical products and of tea in filter bags.
IMA IS YOUR KEY TO ENSURING CONTINUING
EFFICIENCY AND COMPETITIVENESS IN THE GLOBAL
MARKET: ALWAYS AT YOUR SIDE
IMA is present in over 70 countries, supported by a sales network made up of nine branches
which provide sales and service in Spain, Portugal, France, the UK, Germany, Austria, the US,
Thailand and China, representative offices in central-eastern Europe and over 50 agencies.
The Group has seven production plants in Italy, one in Germany, one in the UK, one in the
Netherlands, two in the USA, two in India and three in China.
IMA’ s strategic objective is the reinforcement of the position of leadership at world level, in
the role of “general Contractor” for entire production lines.
IMA produces the world’s widest range of automatic process and packaging equipment for
the primary and secondary pharmaceutical manufacturing processes.
With the total acquisition of the freeze drying machinery business of the BOC Edwards
Pharmaceutical Systems Group, undisputed leader in this sector, the IMA Group has
consolidated its strategy of presenting itself to customers as a sole provider of complete
solutions. IMA Edwards, with its wide product offering including state of the art loading &
unloading systems, operates through production facilities based in the USA, the Netherlands
and China.
Getting innovation to circulate on a world scale is equally essential if a firm is to come out on
top of an ever changing market scenario with constantly new demands and requirements.
But IMA is not only “machines”. We invest nearly 7% of the turnover in R&D to develop new
technologies related to the machines, working groups, material handling, etc.
THE CAPACITY FOR INNOVATION IS AN ABSOLUTE
PRIORITY IF A COMPANY WANTS TO GROW AND RETAIN
THE COMPETITIVE EDGE
Getting innovation to circulate on a world scale is equally essential if a firm is to come out on
top of an ever changing market scenario with constantly new demands and requirements.
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IMA AT YOUR SIDE
SUPPORTING
YOU WITH
INNOVATION
Granulation equipment
Intermittent and continuous capsule filling machines
Check weighing machines for capsules and tablets
Centrifugal die filling tablet presses
Force feed tablet press machines
Peripheral equipment
Automatic equipment for coating process
Powder handling and washing systems
High, medium and low speed blister packaging machines
Bottle Unscramblers
Vision System Counters
Electronic Counters
Slat Counters
Desiccant Inserters
Cottoners
Cap and Container Elevators
Tablet Elevators
Rotary Tables
Integrated aseptic systems
Bottle Blowing machines
Rotary washing machines
Linear washing machines
External rotary washing machines
De-pyrogenating tunnels
Aseptic liquid filling & closing machines
Aseptic powder filling & closing machines
Macrodosing powder filling machines
Multifunction liquid filling & closing machines
Liquid filling & closing machines for cosmetics
Industrial freeze dryers
Pilot freeze dryers
Loading systems
Labelling & ancillary equipment
Depacking machines
Tray loaders
Horizontal cartoning machines
Vertical cartoning machines V
Overwrapping machines
Stretch /shrinkwrapping machines
Case packing machines
Traypacking machines
Palletizing machines
Tray forming machines
Complete processing and packaging lines
Granulation equipment
Intermittent and continuous capsule filling
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SALES AND SERVICE THROUGH THE WORLD
A team of experts is available, to ensure that all requirements are carefully examined in close
collaboration with the customer during the initial stages of project development in order to
identify the optimum technical solution every time.
IMA has the size, core skills,
experience and expertise needed to deal with complex and customized projects.
IMA can manage large-scale projects, design and manufacture solutions to meet special
end-user requirements.
Our After-Sales Service is staffed by skilled engineers and supervisors who take customer calls
and provide prompt support with any type of electrical or mechanical query.
After-sales service is also provided by skilled engineers working out of IMA branches and
subsidiaries. On-site after-sales network in many countries, fully co-ordinated from IMA
headquarters. These locally based engineers have been trained in Italy and Germany.
IMA guarantees technical assistance at the customer’s site throughout the entire life-cycle of
a machine. In order to ensure the highest levels of technical assistance, IMA employs trained,
skilled technicians who are kept constantly up to date with the latest technical developments
in their sector. Having a locally-based TA technician brings IMA closer to the customer
ensuring that we have a fuller understanding of customers’ production needs and can thus
ensure high levels of customer satisfaction.
Ima’s Wide-ranging Sales
Network Currently Comprises
Ima Subsidiaries Offering Sales
And After Sales Services In Italy,
France, Spain, United Kingdom,
Germany, Austria, United States,
UNITED KINGDOM
IMA UK LTD
Central And South America,
FRANCE
IMA FRANCE E.U.R.L.
China As Well As Representative
GERMANY
IMA GERMANY GMBH
Offices In Central And Eastern
CENTRAL AND EASTERN EUROPE
I.M.A. EST
European Countries,
HIGH STANDARDS IN AFTERSALES TECHNICAL ASSISTANCE
HAS ALWAYS BEEN CENTRAL TO IMA’S CUSTOMER
ORIENTED POLICY
South East Asia,
SPAIN
IMA IBERICA
PROCESSING AND PACKAGING SL
And Over  Agents.
U.S.A., CANADA AND PUERTO RICO
IMA NORTH AMERICA, INC.
Three Manufacturing And
CENTRAL AND SOUTH AMERICA
IMAUTOMATICHE LDA
Madeira (Portugal)
After-sales Joint-ventures
In China.
Dealers In Japan.
A global approach to customer problems.
Prompt and effective technical assistance
throughout the entire life cycle of the
machine.
Global management of line problems for
complete lines supplied by ima.
Direct involvement of engineering departments
as required.
(Offices in Bucharest, Moscow, Prague and Warsaw)
SOUTH EAST ASIA AND OCEANIA
IMA PACIFIC CO. LTD.
Bangkok (Thailand)
CHINA
IMA PACKAGING AND PROCESSING EQUIPMENT
(BEIJING) CO. LTD.
TIANJIN IMA MACHINERY CO. LTD.
ZIBO IMA XINHUA PHARMATECH CO. LTD.
IMA EDWARDS BEIJING
PHARMACEUTICAL SYSTEMS
IMA IS A GLOBAL SUPPLIER FOR THE PHARMACEUTICAL
AND COSMETIC INDUSTRIES
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ENGINEERING AND COMPLIANCE SERVICES
P.A.T.
P.A.T. system goals:
(PROCESS ANALYTICAL
TECHNOLOGY)
<
Improves process knowledge, allowing
identification and management of
variability (risk mitigation strategies);
<
Improves product quality, by developing
processes that can consistently ensure
quality (quality by design);
<
Increases automation to improve
operator safety and reduce human
errors, product wastes and reprocessing;
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Can replace the QC lab’s historical role
of raw materials testing, batch testing,
and finished product testing;
<
Reduces inventory and production
cycle times by using on-, in-, and/or atline measurements and controls and
therefore reduces manufacturing costs
(real time release, no quarantine, no inprocess inventory, less testing costs);
<
Facilitates products and process
innovation and improvement.
In September 2004 FDA published the guide “PAT – A Framework for
Innovative Development, Manufacturing and Quality Assurance”,
encouraging manufacturers to use the latest scientific advances in
pharmaceutical manufacturing and technology within a Risk-Based
Approach environment.
P.A.T. is a system for designing, analyzing, and controlling
manufacturing through timely measurements (i.e., during
processing) of critical quality and performance attributes of raw
and in-process materials and processes with the goal of ensuring
final product quality.
A in-depth knowledge of the products to be filled and
of the packaging methods in general are the essential
pre-requisites to design complete packaging and processing lines
developed customizing the different production requirements
and offering a “turn-key” solution which also includes backup and
technical service.
The services offered range from the technical commercial approach
to the systems packet(designing and proposal of line configurations
with a high number of variables) to the technical – functional aspect
(capacity to prefigure, programme and organise the production
and integrated commissioning of several machines from several
production sources) to the efficient centralised advisory service that
provides the pharmaceutical partners with a unique reference point.
Thanks to its flexible product range and highly qualified engineering
staff, IMA can rightly be considered as the company capable of
offering global solutions to complex requirements.
After several years of using the most advanced technology, and
through the constant research and development of innovative
engineering solutions IMA is able to satisfy a wide range of
packaging requirements.
We have kept pace with innovations in pharmaceutical technologies
& processes thanks to teams of highly motivated personnel radically
rethinking everything once considered being standard.
This has put IMA years ahead of other automatic machinery
manufacturers, achieving levels of quality and productivity unheard
of in the past.
IMA focus on developing and implementing
P.A.T. systems and is therefore your perfect
partner to evaluate customized solutions.
OUR OBJECTIVE IS TO ESTABLISH
A PARTNERSHIP WITH OUR CLIENTS,
NOT ONLY SUPPLYING EQUIPMENT
BUT ALSO PROVIDING SOLUTIONS FOR
YOUR COMPLEX PROJECTS AND, WHERE
APPROPRIATE, INCORPORATING THE
SKILLS AND CAPABILITIES OF THE WHOLE
IMA GROUP
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IMA’S QUALITY SYSTEM
IMA LEADER IN RESEARCH
Upon concluding the development oriented around regulation DIN/ISO9001 and
after rigourous auditing IMA was awarded the ISO9001 Certification in 1997.
This means that all the stipulated criteria for quality, inspection and testing regulations
have been fulfilled without reservation.
Regular internal audits and six-month supervisory auditing conducted by SGS
guarantee that internal quality procedures are continuously updated.
Investment in research and development ensures that we canfulfil this commitment.
Quality standards can be grouped in the following categories:
- standards of processes, which include extensive documentation of the quality
system, organisation and management principles, detailed operation structuring.
- standards which pertain specifically to pharmaceutical safety. These essentially
consist of the integration of GMP regulations into the quality regulations and result
in safety precautions in the individual levels of management and production.
IMA has obtained the gost r Certificate and the Hygienic Certificate to export to
Russia thus getting customer free from this commitment.
WE AIMS TO PRODUCE FLEXIBLE,
TOP PERFORMANCE VALIDATED MACHINES AND
LINES PRODUCING QUALITYCERTIFIED PRODUCTS
IMA has always assisted the users of its
machines in achieving effective production,
guaranteeing, by means
of constant research and development,
the maximum efficiency, flexibility and
versatility of the technology supplied
as well as the certified quality of its
organisation and quality of packaged
products by means of expert support in the
validation of machines and production
lines.
The main enterprises to work with IMA
are those which like the Pharmaceutical
Industry make particular high demands
on the quality assurance systems.
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In planning automatic machines that most effectively satisfy the primary,
secondary and end-of-line packaging demands of the pharmaceutical and
cosmetics industries.
IMA made the strategic and operational decision to be at the forefront
of Research and Development and by using all their expertise and
technology in automatic processing and packaging equipment sector
IMA has achieved both product and market leadership.
IMA's engineering team comprises approximately 460 designers and
engineers specialised in various disciplines (mechanics, electronics,
software); it is a highly proficient and experienced team capable of
interpreting the requests of the product marketing people into projects
for machines and lines incorporating the most advanced technological
solutions available.
The IMA Group holds over 630 patents registered in various countries and
the professional skills of its research staff are acknowledged throughout
the world.
PRODUCT INNOVATION IS DEVELOPED BY
MEANS OF CONTINUOUS CONTACT WITH
CUSTOMERS, LEADING TO AVANTGARDE
SOLUTIONS WHICH RESPOND TO THE
CUSTOMER’S REQUIREMENTS AS WELL TO
MARKET DEMAND
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IMA Active is the ideal partner for each solid dose
processing phase: Granulation, Tableting, Capsule Filling,
Coating, Handling and Washing.
The IMA Active solutions are based on dedicated
experience and technology, and take advantage of the
know-how of experts specialised in individual product
lines, but also capable of using this knowledge to work
together with others as part of a team. This is why
IMA Active is your partner for excellence, not just for
integrated equipment but also for specific installations.
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GRANULATION
IMA HIGH SHEAR MIXER GRANULATORS,
MILLS AND FLUID BED DRYERS CAN
BE EASILY INTEGRATED FOR CLOSED
GRANULATION LINES.
IMA’s experience in granulation has grown with the acquisition of
Zanchetta that had launched on the market the first High Shear
Granulator Dryer with tilting bowl in 1984.
Furthermore IMA’s experience in Fluid Bed Technology and a
constant commitment to innovation assures a wide range of
equipment and technical solution for wet granulation and drying.
All IMA equipment are based on a modular design so to match
any kind of requirements providing the highest manufacturing
flexibility, safety and performance either in terms of process or
cleaning. IMA granulation technology is available in laboratory and
pilot scale too.
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GHIBLI
VORTEX
ROTO CUBE
Ghibli Fluid Bed Equipment can be configured according to a
modular design to perform granulation, drying or coating process.
Patented design of rotating filter chamber allows easy
maintenance and replacement of filters made of different
materials according to the purpose.
For CIP arrangement and easy cleaning validation IMA patented
stainless steel filters with dedicated CIP devices.
Vortex High Shear Mixer Granulator has a basic simple design
to facilitate process and cleaning operation. Vortex can be easily
integrated with Mills and Fluid Bed Dryers for close granulation
lines to minimize contamination during product transfer.
Roto Cube High Shear Granulator Dryer allows to manufacture the
entire granulation drying process in a single self contained bowl.
Vacuum and tilting bowl features take the highest efficiency in
drying. It is quite easy to equip Roto Cube for CIP or integrate it
in a plant for totally contained process. The lifting bowl options
facilitates product loading and unloading operations.
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TABLETING
WEIGHT CHECKING
Precisa series of check weighers for capsules and tablets
features a balcony structure, guaranteeing easy access to the
work area. The continuous motion system used for placing
the product on the weighing cells eliminates vibrations and
ensures the maximum accuracy even at high speeds.
IMA Active includes two tablet presses
production sites, one in Italy and one in Germany,
where Kilian force feed presses are manufactured.
IMA’s presence in the tableting market is
very recent, beginning in 1995, when the
first of the revolutionary Comprima series
of tableting machines was launched. The
acquisition of Kilian, in January 2000, has
brought on the tableting side, the long
experience and the high differentiation of
technical solutions IMA already had in the
capsules sector.
IMA Solid Dose is now the only
manufacturer of tablet presses offering
both centrifugal and force feed die feeding
presses, both Cleaning In Place and
Interchangeable turret.
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A complete range of peripheral equipment is also
available including Advantech Plus dedusting unit,
metal detectors, systems for checking diameter,
hardness and thickness of the tablets, quality
sampling devices, etc.
E150 PLUS AND S250 PLUS
COMPRIMA
SYNTHESIS
PRESSIMA
E150 Plus and S250 Plus Kilian force feed tablet presses are probably
some of the most famous tablet presses in the world, well known
for their proverbial reliability, low service costs and long life. They
are easy to operate, with quick cleaning and machine conversion,
manufactured to produce excellent quality tablets at high output
and reasonable price.
Comprima series of presses feature centrifugal die filling,
guaranteeing yields up to 99,5% and improving powder feeding:
maximum production speeds are possible even with shaped
tablets or difficult to handle products. The long compression time
improves tablet quality even at high speeds, while the complete
separation between processing area and mechanical parts reduces
size change time and makes it possible to fit the machine with a
completely automatic Clean In Place.
The Synthesis tablet press machines feature force feed die filling
technology. The interchangeable die table and the complete
separation of the production area from the mechanical parts allow
fast cleaning operations, quick size changeover, less maintenance
operations and no risk of cross contamination. The patented punch
bellow arrangement guarantees 100% “black spot” free tablets.
The machines are all equipped with a quality control system for
automatic machine set-up and can be fitted with a Wash In Place
System.
The Pressima rotary tablet press is for galenic and research
applications. It is the only press of its type equipped with an
interchangeable die table. This very flexible machine is designed
for compressing small batch production and the instrumented
version allows complete control of all production parameters.
Good accessibility facilitates cleaning and maintenance.
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CAPSULE FILLING AND BANDING
IMATIC and ZANASI capsule fillers can be
configurated for contained production of
high potent products
IMA’s experience in capsule filling goes back to the first automatic
machine for dosing pharmaceutical and non pharmaceutical
products in Hard Gelatine Capsules, produced in the 50's by Zanasi,
acquired by IMA in 1985.
IMA is the only manufacturer of capsule fillers in the world in a
position to offer a complete range of machines for the processing of
hard gelatine capsules, including both continuous and intermittent
motion machines, and a wide range of dosing systems and
technological solutions, ensuring excellent results for all types of
products. The latest innovation is the Hermetica capsule banding
machine.
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ZANASI
IMPRESSA
IMATIC
HERMETICA
The Zanasi and Zanasi Plus intermittent motion capsule fillers for
low and medium production requirements represent probably
one of the most successful products in the capsule filling field: they
are easy to operate and maintain, with very low size changeover
and cleaning times and high flexibility. The PLUS version features
the same user friendly structure but with an increased number of
dosing units and automatic adjustment of working parameters.
The new Zanasi Lab models ensure maximum flexibility for R&D
and clinical trials.
The Impressa capsule fillers are intermittent motion machines
covering medium and high speed requirements. The powder
dosing unit with tamping pins and the volumetric pellet dosing
unit working principles minimise product losses, avoid product
contamination with metal particles and allow separate adjustment
and control of weight and compression, ensuring at the same time
flexibility and dosing precision. The machine can be also fitted with
a volumetric liquid dosing group.
The Imatic series of continuous motion capsule fillers covers
medium and high speed requirements.
The single turret operating system ensures maximum dosing
precision and reliability even at very high speeds, and allows the
machine to be fully automated. All size parts have been paired,
reducing the number of parts to be changed in order to minimise
non productive times, a completely automatic Clean In Place
system can also be applied.
Hermetica is a highly automated capsule banding machine: the
banding is achieved through the application of a ring of liquid
gelatine on the external surface of the capsule. The machine
features easy operation and automatic handling of gelatine
working parameters. A 100% checking system through camera can
be additionally fitted, to control and select each individual banded
capsule.
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COATING
In both solid wall and perforated pan, the
well-designed spraying system ensures easy
maintenance, simple inspection operations
and quick changeover from one product to
another.
All cleaning operations are easy and fast
thanks to the automatic clean-in-place
system: the cleaning cycle can be adjusted
according to each product requirements.
The quality and the process technology offered by the IMA Coating
Equipment are the result of the experience derived from over 800
successful installations all over the world. This experience, together
with the continuous research, the strict collaboration with raw
material producers and universities allow to develop high quality
equipment for an optimal production process.
ALL SIZES AND SHAPES OF PRODUCT CAN
BE PROCESSED ON GS SOLID WALL PAN:
SHAPE AND SURFACE SMOOTHNESS
LEAD TO PERFECT CORES MIXING AND
UNIFORM DISTRIBUTION OF COATING
MATERIAL
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SOLID WALL PANS
PERFORATED PANS
IMA GS coating equipment, with solid wall pan, can process all sizes
and shapes of product without clogging: tablets, microgranules
and pellet film and sugar coating can be performed on the same
machine. The patented core drying system, consisting of two air
blowing or exhausting paddles, immersed in the product bed,
guarantees a uniform and constant drying effect.
GS Evolution machines, made for highly automated installations,
can be also configured for processing high potent products.
The innovative IMA Perfima perforated pans maintain the same
shape and mixing baffles positioning of the IMA GS pans: this
shape has proven over the years to guarantee the best mixing
results. The unidirectional air flo w guarantees a perfect drying of
the cores avoiding turbulences inside the pan.
IMA is the only manufacturer able to supply
both solid wall and perforated pans ensuring
a perfect mixing, a uniform coating and the
highest flexibility, allowing a wide range of
batches to be processed in the same drum
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HANDLING AND WASHING
Zanchetta powder handling and washing systems make
it possible to link all IMA equipment on a complete
installation for solid dose production
IMA's experience in the handling and washing
market began in 2003 and became stronger
thanks to the acquisition of Zanchetta in
2007, a company with a long-standing knowhow on these equipment. Thanks to this
acquisition IMA is able to offer complete
installations for solid dose production, from
raw material dispensing to processing and
feeding of the final packaging lines, as well
as a wide range of washing equipment: from
the simplest washing group to completely
automatic washing cabins and fastrooms.
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PHBIN AND PHDRUM
CYCLOPS AND CANGURO
HERCULES
The PH-Bin and PH-Drum are product
containers designed for handling powders
and granulates for the pharmaceutical, food
and chemical industry. Both equipment are
manufactured in Stainless Steel with Pharma
finishing complying the most restrictive
GMP rules.
T-BINs are also available for tablets and
capsules handling.
The Cyclops series of Bin Tumblers, for
blending and homogenising powders and
granulates, feature the innovative TRIGON
System, a universal Bin Blocking System with
a unique Pharma GMP design, simplifying
loading and unloading operations.
The Canguro tumbler is available for standard
bin blending. The possibility of “Through the
Wall” installation minimizes the space in the
production area, reducing cleaning times.
Hercules Lifting Columns are designed to
lift IBCs, drums, small containers or small
machines as pneumatic conveyors or mills.
These machines comply the most restrictive
GMP rules and are safe thanks to the unique
Self Brake System to hold up the load in case
of emergency. Different Hercules models are
available according to lifting capacity; the
bigger versions can be additionally fitted with
the MIX feature for Bin/Drum Blending.
AIR CHAMBER
AND TMAIL
The Air Chamber and the T-Mail are
product transfer systems suitable for
powders, granules, tablets or capsules. These
equipment avoid product de-mixing or
damage and guarantee very low cleaning
times thanks to the disposable polyethylene
liner.
TWINVALVE
WASHING SYSTEMS
The highly innovative TwinValve connection
System is designed for maximum efficiency
for both standard and high potent products.
The possibility to use compressed air and/
or water cleaning on the same connection
makes the installation suitable for working a
wide range of active products. TwinValve can
be easily retrofitted on existing installations.
Different washing systems can be supplied
with different levels of automation and
functions. The HydroWash is a self-regulating
modular C.I.P. group working in manual
and semiautomatic washing configuration.
Atlantis or Ocean bin washing cabins are
available in different configurations and
dimensions to wash bins, drums and pallets.
Venus components washer is also available
to wash small components such as hoppers,
small containers and drums.
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IMA LIFE, in the aseptic processing field, offers the
pharmaceutical industry a wide range of machines
designed to meet the most stringent FDA and EMEA
regulations, from advanced equipment through to
traditional fillers for generics. Acting not only as
a machine manufacturer but mostly as a solution
provider, IMA LIFE satisfy the increasing requirements
of the pharmaceutical industry with products based
on consolidated technology as well as with new
developments deriving from a continuous partnership
with pharmaceutical multinationals worldwide.
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BLOWING, WASHING AND STERILIZING
IMA LIFE, is a world leader in the production of equipment for
washing and sterilization of pharmaceutical ampoules, vials and
bottles.
All machines are intended for applications requiring equipment of
high scientific and technological content, where the industry must
comply with very strict standards.
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High technology for the safety of sterilizing
processes.
Validatable sterilization & depyrogenation
technology for the highest requirements of
the pharmaceutical industry.
Decontamination technologies.
We manufacture our washers using strict
decontamination methods, to supply downstream machines with containers which are
absolutely clean and free from any kind of
particles.
BLOWING MACHINES MISTRAL SERIES
ROTARY WASHING MACHINES VEGA SERIES
Suitable for the dry-cleaning of bottles and containers in general,
that do not need cleaning with water or detergents but rather the
removal of solid granular or dusty solids by a sterile air jet.
Blowing machines of the Mistral Series can be part of complete
packaging lines or can serve as stand-alone machines.
The Mistral Series of blowing tables include machines from medium
to high-speed capacity, ranging from 120 to 400 vials/min.
Cleaning systems for small vials and ampoules with a production
speed from 200 to 400 vials/min and a production range from 2
to 100 ml vials.
- 8 washing stations inside and outside by intensive rinsing and spraying
- Mechanical function with gentle handling of containers
- Pre-washing in an ultrasonic bath
- Water recycling stations, siliconizing station
- Quick change-over
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BLOWING, WASHING AND STERILIZING
TUNNEL WORKING CYCLE
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EXTERNAL VIAL WASHERS
HYDRA 300
LINEAR WASHING MACHINES
HYDRA SERIES
DEPYROGENATING TUNNELS
BLUE GALAXY SERIES
The importance of decontaminating filled and capped vials coming
out from an aseptic processing line is satisfied by this series of very
flexible external vial washers
Washing machines for vials and bottles, available in 22 models,
to handle containers from 2 to 500 ml, with a production
speed from 175 to 600 vials/min. Designed according to cGMP
recommendations, satisfying the highest quality standards required
by pharmaceutical industries.
- The standard versions are equipped with 8 washing stations, that
can be increased up to 13
- Quick size change-over and simple use
- Single or double recycle station
- Automatic drainage
- Steam in place (S.I.P.) with temperature recording
BLUE GALAXY is a Series of de-pyrogenating tunnels designed
to be inserted in production lines that require continuous depyrogenation by means of dry heat, that guarantee air quality as
per US Federal Standards 209/e, the repeatability and the absolute
control of the process for glass vials and ampoules.
The wide range of tunnels manufactured enables us to satisfy any
production requirement, in the same way as the high technology
allows the use of our tunnels for any kind of application.
Ima Life tunnels can be easily integrated into lines for processing
products with high toxicity and/or be in line with isolators.
In this case, the tunnel can be equipped with DRY HEAT
STERILIZATION of the cooling zone or with an exclusive, Ima Life
patented system FOR STERILIZING WITH VHP.
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ASEPTIC LIQUID & POWDER PROCESSING
Latest trend in aseptic manufacturing.
MAC: Proven Aseptic Technology, automation and control of
a Production Line combined with the Compact Area typical of
R&D environments. Standard SVP vial processing as a batch or
continuous process using premium technology.
A COMPACT AND SINGLE UNIT THAT
MEETS ALL STRINGENT FDA AND EMEA
REGULATIONS, ELIMINATING RISKS AND
ENSURING REPEATABILITY AND COST
REDUCTION
MAC is suitable for:
- Laboratory Batches
- Small Production Capacity
- Clinical Trials
Repeatable processes and reduction in risks associated with reduced
customization and cost saving.
FROM MACHINE MANUFACTURER TO
SOLUTION PROVIDER
MAC
MODULAR ASEPTIC COMPACT SYSTEM
MAC is a MODULAR ASEPTIC COMPACT SYSTEM designed
according to a new working philosophy based on a consolidated
filling technology for aseptic environments.
MAC incorporates a washer, tunnel, filling, stoppering and capping
operation in a single mono-block system for liquid, lyo or powder
with RABS or Isolator.
All control parts are integrated on the monoblock frame and
include most of the utility generators necessary for correct
functioning and operation. These features make the unit easy to
transport on standard shipping systems.
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ASEPTIC LIQUID & POWDER PROCESSING
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ASEPTIC LIQUID FILLING IN VIALS
STERIFILL SERIES
ASEPTIC LIQUID FILLING
IN PLASTIC UNIT DOSE
IMA Life machines for aseptic liquid filling in vials are distinguished
by their rigorous design detail, the result of careful research in fluid
dynamics, to guarantee maximum product protection for all aseptic
filling environments (such as traditional clean rooms or isolation
technology). Compact and ergonomic design assure great flexibility
in all types of lay-out. Statistical & 100% IPC control of filled weight,
along with very advanced CIP/SIP units and with a positive transport
system, allow the machines to reach a very high standard in product
quality. The production ranges from medium to high speed sterile
filling & stoppering machines, with or without R.A.B.S. or isolator,
with a production speed from 100 to 600 vials/min.
The use of unit dose containers to pack sterile pharmaceutical
products is becoming increasingly popular due to the many
advantages offered in terms of product safety, dose accuracy and
ease of use.
IMA Life has developed the SL series of machines dedicated to
the dosing of liquid products into monodose containers that can
satisfy all production requirements. With a high degree of flexibility,
these machines can reach an output up to 375 unit doses/min and
can be easily integrated in high-speed production lines.
SL SERIES
ASEPTIC POWDER FILLING IN VIALS
MICRODOSING SERIES
The machines of the Microdosing series are used by major
international companies for the dosing of injectable powders in
vials, establishing IMA Life as the world leader in the micro dosing
machine market. The heritage of more than 40 years dedicated
to all aspects of pharmaceutical powder filling, with hundreds of
machines produced and working all over the world: all this allows
the development of this very innovative filler which features 100%
checkweighing system for all vials filled. Using the vacuum/pressure
dosing system, the machines of this series can reach on output
speed up to 400 vials/min and they are all pre-arranged for RABS
or Isolator attachment.
ASEPTIC CAPPING
ALU SERIES
The machines dedicated to the capping of vials for injectable
products are an extremely important and critical path of the
production process, since they guarantee the hermetic seal and
therefore the integrity of the drug inside the container. IMA Life
designed and built the ALU Series of capping machines with a new
system to control the vertical load applied on each vial and a low
particle generation capping system with vial rotation against an idle
disc. The ALU Series is therefore particularly suitable for installation
in clean-rooms or under isolators. Special aseptic applications have
been developed to apply ADD Vantage and Bio-Set sterile caps. The
machines of the ALU Series reach an output speed of 600 vials/min.
31
ASEPTIC LIQUID & POWDER PROCESSING
INTEGRATED SOLUTIONS
IMA Life provides fully integrated, allinclusive solutions tailored specifically
to individual customer requirements. Our
systems are implemented by a team assembled
from highly experienced individuals who are
specialised in addressing the special challenges
associated with regulated pharmaceutical
environments. Our resources are able to help
you every step of the way; from equipment
specification and selection through to
process support and validation, helping to
eliminate time and cost overruns which can
occur at critical interfaces.
Quality extends beyond our systems offerings
and on into the broad range of services we
can provide, so that with IMA Life you can
be assured of continued productivity and
reliability.
OPTIMIZED PROCESS INCREASE
PRODUCTION EFFICIENCY
ISOLATION TECHNOLOGY
Isolation technology is now used with Increasing frequency.
Combined with automated filling systems for liquid or powders,
isolation technology minimises the direct human intervention in
the processing area and is now a technology that is being rapidly
adopted by the pharmaceutical industry.
The use of this technology on filling machines offers obvious
32
economic advantages as well as operating benefits while assuring
greater product sterility.
Although interest on the part of the pharmaceutical industry in
the use of isolators is relatively recent, ima life has already acquired
a solid experience, producing aseptic filling lines for dosing liquids
and powders using Various types of isolators and creating highly
flexible mechanical interfaces.
33
FILLING & CLOSING IN PHARMACEUTICAL AND COSMETICS
Almost  machines for more than 
different applications: this is the experience
and background that IMA LIFE makes
available to its pharmaceutical customers
in the field of multipurpose liquid filling
and closing machines. The machines of
the Multifill Series, either intermittent or
continuous motion, fill different types of
product applying different types of closures
(ophthalmics preparations, intranasal
products, suspensions, oral drops, drinkables,
sugary syrups, detergent/disinfectant
solutions etc.).
COUPLED WITH YEARS OF CONSOLIDATED
EXPERIENCE THE IMA LIFE CONTINUOUS
INNOVATIVE SPIRIT SETS A MILESTONE IN
DRUGS PROCESSING ASSURING FLEXIBILITY
AND RELIABILITY AT THE SAME TIME.
34
LIQUID FILLING & CLOSING MACHINES
MULTIFILL SERIES
INLINE LIQUID FILLERS
FLEXIFILL SERIES
POWDER FILLING & CLOSING MACHINES
MACROMATICA
Particularly versatile MULTIFILL F800 Series has been conceived to
reach an output speed of up to 450 bpm with up to 24 filling heads
and 10 closing heads. The dosing volume can be set up to 1000 ml.
Thanks to its constructive modular design, the machine can handle
all types of plastic and glass bottles, in any shape, and all the closures
typical of the pharmaceutical industry.
Ideal for big batches production, MULTIFILL F800 series of machines
can be equipped with the latest generation of completely automatic
CIP-SIP systems. Fast and simple change-over, together with low
maintenance, guarantees user friendliness.
Designed to satisfy the flexibility demand of the pharmaceutical
industry this series of fillers consists of various kinds of machines
that can be either electronically or mechanically driven, intermittent
or continuous motion.
Macromatica is suitable for filling powders into bottles for the
preparation of syrups. It is designed and built on the basis of the
experience gained in powder microdosing with the Microfill series
of machines.
Very compact and ergonomic, FLEXIFILL offers high flexibility
in terms of liquid drugs as well as container shape and type;
reliable and innovative, based on modular constructive design,
this Series of machines has an output speed ranging from 120 to
250 bottles/min.
Macromatica can also be fitted with two dosing discs and therefore
maintain a high production speed and efficiency, even with large
doses, or in case of dosing shared in two operations with poor
flowing powders, to maintain a high production efficiency.
35
FREEZE DRYING SOLUTIONS
IMA Edwards has been supplying pharmaceutical process
equipment for more than 50 years, but our origins arise from when
the Edwards Vacuum company was founded in the UK at the
beginning of the 20th century. Having initially focused solely on
vacuum equipment, Edwards broadened its product portfolio with
the major step of entering the pharmaceutical freeze drying sector
in the early 1950’s. This freeze drying business evolved from the UK
into a production facility in Italy, and having been acquired by BOC
Group in 1968, it further expanded in the 1980’s with a production
site in Germany.
As the pharmaceutical market grew in the US so did Edwards freeze
drying business by establishing our current facility in Tonawanda,
NY in 1989. Moving to 1995, the Dongen facility in The Netherlands
was acquired which brought with it considerable expertise in vial
handling which has spurred our existing leadership position in
automated loading and unloading systems. As we moved into the
21st century, we completed our production footprint by starting
up in Beijing, China in 2004. Today we stand as an integral part of
the IMA Group and are widely recognised as the world leader in
freeze drying solutions.
For more than half a century, Edwards has provided the benchmark
for freeze drying solutions to the pharmaceutical and biotech
industry. With a truly global presence with main facilities well
positioned to serve customers in all corners of the world. With
over 1000 freeze dryers installed in over 50 different countries,
IMA Edwards is ready to leverage this experience to better serve its
customers needs.
36
IMA EDWARDS PRODUCTION RANGE:
 NDUSTRIAL FREEZE DRYERS
 PILOT FREEZE DRYERS
 LOADING SYSTEMS
37
FREEZE DRYING INDUSTRIAL EQUIPMENT
IMA Edwards freeze dryers support a wide
range of pharmaceutical packaging needs.
The Lyofast and Lyomax ranges cover
anything from pilot models up to large
production units.
Products can be conditioned in bulk, vials,
ampoules or other type of containers such
as cartridges or syringes.
IMA EDWARDS HAS BEEN CONSISTENTLY
AT THE LEADING EDGE OF FREEZE
DRYING AND LOADING SYSTEMS
INNOVATION…
PUTTING NEW TECHNOLOGY TO WORK
FOR ITS CUSTOMERS
38
LYOMAX
LYOFAST
MINIFAST
Lyomax comprises the most comprehensive range of custom-built
freeze dryers for those who require more than a standard solution.
Lyomax can provide the solution from 1 m2 to 100 m2 applying
state of the art engeenering in vacuum, refrigeration, stoppering
and heat transfer technology. Created for configure-to-order
applications using Modular Design Technology, Lyomax can be
designed, manufactured and qualified to meet any requirement.
With Lyomax, virtually any configuration is possible, whether single
floor, multi-level or pass-through.
A series of standard modules provide the foundation of the Lyofast
model concept. Pre-engineering results in time and cost benefits,
while a wide range of standard options ensure sufficient flexibility
over a broad range of configurations.
By constructing from a series of standard modules, IMA Edwards
is able to compress project schedules and reduce lead timeseven with large capacity equipment. Compared to a custom-built
lyophiliser, the lead time for Lyofast is reduced by up to 50%. This
provides the customer with a competitive edge by reducing the
time to market.
With the introduction of the Minifast range of lyophilisers, IMA
Edwards has established the connecting factor between a typical
bench-top freeze dryer used in laboratories and the industrial
Lyofast or Lyomax range of freeze dryers. The Minifast provides
you with the direct ‘line of sight’ required by the FDA between the
pilot type freeze dryer that is suitable for scale-up and the larger full
production freeze dryers.
In order to gain control of development time and cost in custom
engineering, IMA Edwards applies Modular Design Technology
(MDT), which allows for the well-balanced use of pre-engineered
modules wherever possible. The Lyomax range is equipped
with the latest SCADA system, managing a robust series of PLCs
to cover global requirements. The machines are all qualified in
accordance with GAMP4 and comply with the latest FDA and
EMEA requirements.
PILOT FREEZE DRYERS
39
FREEZE DRYING LOADING SYSTEMS
AUTOMATIC & SEMIAUTOMATIC
The drive for automation is clear from a
number of angles:
IMA Edwards is one of the few suppliers in
the world that designs, manufactures and
tests a full range of PROVEN SYSTEMS
FOR FULLY AUTOMATIC LOADING
AND UNLOADING VIALS into industrial
freeze dryers.
<
Minimises human intervention and
thereby supports the assurance of
product sterility (SAL levels); reduces
bio-burden; and reduces operating costs
<
Protection of operators depending on
potency of products
<
Repeatable standards and reduction in
room air classification
<
Increased equipment availability
THE SYSTEMS ARE DESIGNED TO CONTINUOUSLY TRANSFER
VIALS FROM THE LIQUID FILLING EQUIPMENT TO THE FREEZE
DRYER AND FROM THE FREEZE DRYER TO THE ALUCAPPER
FIXED SYSTEMS
FLEXIBLE SYSTEMS
MIXED SYSTEMS
APPLICATION DEMANDS
Fixed automatic loading systems are generally
a more cost-effective solution when one
or two freeze dryers require loading, and
simultaneous operation is not required for
loading and unloading. More freeze dryers
can be supported if they are in pass-through
configuration.
Flexible loading systems can serve multiple
freeze dryers and perform multiple scheduled
tasks. Loading systems consist of a loading
accumulation table (LAT), integrated with
the out-feed of the fill line, which collects and
moves vials in a vial pack equivalent in shape
and size to each freeze dryer shelf. Once a vial
pack is created on the LAT, a Transfer Cart
(TCAR) collects the vial pack and transfers
the pack onto the designated freeze dryer
shelf. At the end of the freeze drying process,
the TCAR collects the vial packs from the
designated freeze dryer shelf and transfers the
vial pack to an unloading accumulation table
(UAT) or Unloading Accumulation Buffer
(UAB), where the vials are de-scrambled for
single lining to the alu-capper.
These systems offer a combination using
fixed and flexible solutions:
IMA Edwards not only designs your systems to ensure operating
excellence, but also ensures your time to market is efficient from
installation, documentation and commissioning through to process
validation, certifcation and qualification.
The Fixed system consists of a conveyor
integrated with the out-feed of the filling line,
which transports vials to a loading/unloading
station installed in front of the freeze dryer.
40
- Only pass-through configurations, loading
operating up to 450 vials per minute and
unloading up to 900
- Fixed loading and Flexible unloading
- Flexible loading and Fixed unloading
- vial formats from 14.25mm to 51mm
- vial diameters from 2ml to 100ml vial sizes
- Loading row by row on a bridging plate with the last row pushing
the whole package onto the shelf
- Loading a number of rows together onto the bridging plate as an
individual package then into final shelf position
- Loading a number of rows together onto the leading edge of the
shelf, with each next row sequencing the entire pack
- Advanced, proven techniques to cope with various cold shelf
loading considerations: airflow, temperature differences between
environment and shelf, condensation levels on shelf, ice on shelf,
elapsed/dwell time from filler to buffer to loading system.
41
FREEZE DRYING SERVICES
Technology has always been at the heart of
everything IMA Edwards does. In putting
this technology to work and gaining control
of development time and the expense of
customer engineering, IMA Edwards applies
Modular Design Technology (MDT).
This provides the opportunity for the wellbalanced use of pre-engineered modules in a
customer’s application.
PREVENTIVE
MAINTENANCE
Using its extensive experience, IMA
Edwards will provide the customer with
a comprehensive, tailored solution based
upon specific needs. The preventive
maintenance program is an integral part of
the cGMP approach, and therefore has to
be carried out by qualified personnel only.
All maintenance will be properly
documented to support the customer
during corporate audits and regulatory
inspections.
An effective and approved preventive
maintenance programme will:
- Assure compliance and the continuity of
validated equipment status
- Make the operation of equipment reliable
- Minimise downtime
- Considerably extend equipment life-span
42
WITH ITS WORLDWIDE PRESENCE AND HIGHLY TALENTED
AND PROACTIVE STAFF, IMA EDWARDS CAN HELP THE
CUSTOMER ANY TIME.
TAKING PRIDE IN ITS RESPONSIVE APPROACH OFFERING THE
CUSTOMER SERVICE CONTRACTS TAILORED TO INDIVIDUAL
NEEDS GUARANTEEING OPTIMAL PERFORMANCE OF
YOUR SYSTEMS AT ANY POINT “IN TIME”. ON TOP OF ITS
COMPREHENSIVE SPARE PARTS PROGRAMMES, IMA EDWARDS
OFFERS A WIDE RANGE OF VALUEADDING SERVICES
VALIDATION SUPPORT
IMA Edwards can provide the customer
with an omni-comprehensive package
of documentation for on-site validation.
The package can include DQ, IQ, OQ and
PQ protocols and support by specialists
for execution. IMA Edwards can support
equipment qualification with a variety of
different approaches:
- Integration between commissioning and
qualification. Based on written procedures,
approved by the customer, IMA Edwards
defines rules (deviation management,
project change control, etc.) to limit the
duplication of effort between FAT/SAT and
IQ/OQ/PQ.
- Risk analysis. Through the analysis of the
critical process parameters and written
rationale, IMA Edwards supports the
customer in defining the scope of the
qualification, setting up initial and periodic
qualification programmes, and integrating
the commissioning and qualification
efforts.
CONTROL SYSTEM
UPGRADES
FREEZE DRYING CYCLE
DEVELOPMENT
IMA Edwards can support the customer
in assessing its control system with respect
to compliance with current regulations,
including GAMP IV and 21 CFR part 11.
Upgrades are available for SCADA, PLC, and
Field instrumentation and are fully debugged
and bench tested in a simulation environment
through to FAT and SAT. They include a fully
compliant documentation package and can
include:
- Validation master plan
- User requirements specification
- Design qualification/traceability matrix
- Functional design specification for PLC
- Block diagrams
- Pin chart
- Functional design specification for SCADA
- Hardware design specification
- Software design specification for PLC and
SCADA
- FAT (Factory Acceptance Tests) and SAT
(Site Acceptance Test) protocols
Our laboratory facilities can offer a complete
set of equipment and facilities for cycle
development study, enabling focus on:
- Optimising the freezing temperature and
cooling time
- Vacuum to optimise the heat transfer from
shelves to product avoiding undesirable
melting
- Product temperature to optimise the
primary and secondary drying time
modifying the shelf temperature and
vacuum with calibrated leak (nitrogen gas
bleeding)
- The secondary drying phase using calibrated
leak and shelf temperature to reduce time
and meet the customer request for residual
moisture
- Measurement of the residual moisture
- Karl Fischer analyser to verify the residual
moisture after lyophilisation
- DSC analyser to verify the eutectic point
and phase transitions
CALIBRATION SERVICES
TRAINING SERVICES
Calibration must fulfill both maintenance
and compliance requirements. IMA Edwards
can develop a comprehensive programme
for you using its extensive experience. Gain
direction for classifying instruments and
setting appropriate limits to ensure product
quality. Avoid unnecessary deviation
investigations. IMA Edwards can also provide
you with calibration procedures and perform
calibration of your instruments with highly
qualified technicians and fully traceable
primary instruments.
IMA Edwards offers a variety of training
programmes for Machine operators,
Electrical and mechanical engineers,
Maintenance engineers, and Supervisory
personnel. Programmes are designed not
only to improve the participants’ overall
understanding of the production equipment,
but also to enhance their confidence and
performance levels to provide the customer
with a beneficial return for its business.
Training programme options:
- Level 1: System fundamentals, operation
and error recovery
- Level 2: Preventive maintenance techniques
- Level 3: Corrective maintenance techniques
- Train the trainer: Course development and
material delivery
43
LABELLING & ANCILLARY EQUIPMENT
SELFADHESIVE TECHNOLOGY FOR
LABELLING OF AMPOULES, SYRINGES,
VIALS, BOTTLES AND CARTONS
WITH FLEXIBILITY, VERSATILITY
AT HIGH SPEED
IMA Life production includes a wide range of labelling machines
which can be an integral part of complete packaging lines or
serve as stand-alone machines known as Sensitive Series, which
comprises a number of highly flexible and high performance selfadhesive labellers, specifically designed to meet the demand of the
pharmaceutical field.
SENSITIVE SERIES
V/VL SERIES
Easy to use and designed according to the latest cGMP’s the
Sensitive Series can cover all the requirements typical of the
pharmaceutical processing, handling glass and plastic bottles and
vials, ampoules, cartridges, syringes and containers with irregular
shapes. Front and rear labelling of elliptical or rectangular based
products as well as application of vignette labels or self-adhesive
tamper evident seals on formed cartons are included in the range.
The Sensitive Series offers today the highest reliability and the
possibility to install different kinds of printing systems, such as hot
foil, ink jet, thermal transfer, laser and all the state of the art control
units, like vision systems, camera pixel counters, bar code readers,
2D code readers.
Following the increasing demand in automation of lyophilization
processes, IMA Life has designed and developed a range of special
traying facilities to ease the loading/unloading operations typical
of lyophilization lines, facilitating transfer operations of vials to/
from the freeze-dryers.
The V and VL Series of tray loaders represent the ideal solution
to all activities concerned with the automatic unloading and
collecting of vials onto trays.
The range of models of the Sensitive Series, is the solution for
various problems concerning primary labelling such as :
- wrap-around labelling of cylindrical products like ampoules,
cartridges, vials and bottles
- front /rear labelling of elliptical or rectangular based products
- application of vignette labels or self-adhesive tamper evident seals
on formed cartons
The distribution and label application units are driven by stepping
motors.
To support the machines’ high specification all models can be
equipped with-:
- overprinting units (hot foil, ink-jet, thermal transfer)
- bar code readers
- checking units
- control camera systems (ocr-ocv)
- automatic reject units
- semi-automatic splicing of label reel without machine stop
44
STARPACK SERIES
The Starpack debundling machines have been developed to
solve the problem of extracting cylindrical glass containers from
polyethylene shrink wrapping and feeding them onto a production
line or downstream machine.
Semi-automatic and automatic de-packers offer the possibility of
further enhancing the performances of complete processing lines,
with an output speed up to 240 bundels/min.
45
IN
G
KA
C
PA
G
L
SO
U
NS
O
TI
Protect your products: IMA SAFE is at the forefront
for packaging pharmaceuticals and cosmetics. A
complete range of primary and secondary packaging
machines provides customers with flexible solutions
with high efficiency outputs.
IMA SAFE offers the widest range of BLISTER & TRAY
PACKAGING MACHINES, TABLET & CAPSULE COUNTERS,
TUBE FILLERS, horizontal and vertical CARTONERS and
END-OF-LINE EQUIPMENT.
Global technical services and assistance reinforce and
enhance IMA Safe’s market leadership.
46
47
BLISTER & TRAY PACKAGING
IMA SAFE’s experience in blister packaging goes back to 1976 when
the C60 was launched. The C60 was manufactured with totally
new concepts that were the cornerstone to the new era in blister
packaging; the first monobloc blister machine with integrated
cartoner with the ability to count, stack and introduce blisters
automatically. With a speed of 350 blisters/min and 150 cartons/
min, it was the fastest machine in the market. Today, IMA SAFE
blister machines incorporate the latest developments in technology,
electronic and mechanical engineering and are designed to ensure
high production efficiency and low maintenance.
<
continuous forming film motion
<
highly efficient feeding systems
<
integrated cartoners with positive
blister transport
<
stand-alone solutions for specific
requirements (e.g. wallet)
<
reduced changeover and cleaning times
<
balcony design for greater accessibility
<
high mechanical efficiency
<
operator friendly
<
visibility of the material flow
<
conformity to gmp
<
less product and material waste
<
validatable processes
With almost 40 years of experience dedicated to blister packaging
and thanks to more than 3.200 blister machines supplied worldwide,
IMA SAFE has the expertise and core skills needed to the supply
solutions to meet even the most complex end-user’s requirements.
Much of IMA’s success can also be attributed to having the widest
range of blister and tray packaging machines that the market has to
offer, as well as a well having an established worldwide presence and
technical assistance.
WE SOLVE PROBLEMS IN PRODUCT
FEEDING ON A DAILY BASIS
Customers know that they can rely on IMA SAFE’s experience in
feeding systems.
IMA SAFE feeding systems are built in accordance with the GMP
and FDA regulations especially in terms of selecting suitable materials
that remain in contact with the product. Careful and innovative
feeding systems are designed to facilitate cleaning and to reduce
changeover times to a minimum.
Thanks to more than 7000 feeding units supplied worldwide, IMA
SAFE reaches the highest levels of efficiency (99,9%) in handling
every possible kind of product shape. A specific department within
IMA Safe is dedicated to product feeding solutions and includes
several GMP test rooms for product feeding under controlled
environmental conditions. Solutions are found which are based
upon each unique project.
<
Minimal invest with high O.E.E.
<
Fast and easy changeover
<
Flexibility in handling all materials
<
Roller and platen sealing
LOW SPEED FOR BLISTER AND TRAY
IMA SAFE proposes a vast range of solutions for low output
blister and tray packaging machines which enable high Overall
Equipment Efficiencies. Roller sealing and platen sealing models
are manufactured at the IMA plants in Italy and India (IMA SAFE
PG). Machines are GMP designed and address the needs of the
operator for ease of use.
48
PG CLINIPACK
PG TR100 SERIES
PG C102
TR130S
PG SUPER
TR135
PG ROTOVAC 210 SERIES
90 BLISTERSTRAYS/MIN.
150 BLISTERS/MIN.
160 BLISTERSTRAYS/MIN.
220 BLISTERS/MIN.
225 BLISTERS/MIN.
230 BLISTERS/MIN.
240300 BLISTERS/MIN
49
BLISTER & TRAY PACKAGING
technical features:
<
stainless steel covering
<
balcony construction for easier cleaning
and easy insertion of feeding units
<
product area and technical areas separate;
<
reduced energy consumption
<
rapid size changeovers thanks to preset
positioning
<
fast and easy changeover and cleaning
with downtimes reduced to a minimum
<
minimum maintenance and supervision
<
complete automation with simplicity of use
With the Giant1, “the fastest micro-line”, IMA has become the only
company which has successfully addressed the problem of product
recall; a problem which faces the entire drug manufacturing industry.
The patented blister cutting system assures that rejected, faulty,
blisters cannot be re-inserted in further packaging process.
HIGH SPEED
MEDIUM SPEED
Machines from 300 to 600 blisters/minute with solutions that include
both stand alone or integrated cartoners. Machines are designed to
maximise the time needed for format changes and cleaning. A high
level of O.E.E (overall equipment efficiency) is possible, even when
multiple format or batch changes are needed during a single work
shift.
50
C80R
C90A91
C80A81
TR200
GIANT1
400/600 BLISTERS/MIN.
400 BLISTERS/MIN. 270 CARTONS/MIN.
400 BLISTERS/MIN. 250 CARTONS/MIN.
360 BLISTERS/MIN.
350 BLISTERS/MIN. 175 CARTONS/MIN.
When high production output levels are needed - from 600 to
1300 blisters/min and up to 400 cartons/min. Each machine is
designed for rapid and easy format change over and to work with
all packaging materials and blister formats. Maximum flexibility
combined with highest production efficiency.
C96A96
C98
C80HS
1300 BLISTERS/MIN. 450 CARTONS/MIN.
800 BLISTERS/MIN.
700 BLISTERS/MIN.
51
COUNTING EQUIPMENT
IMA SAFE, together with IMA SAFE Nova and IMA SAFE Swiftpack,
can act as sole supplier of the widest range of solutions to the
tablet and capsule counting industry intended mainly for the
pharmaceutical sector.
The Lakso, Merrill and King brands of high-speed slat fillers have a
long and renowned history and have evolved over the last 50 years
to encompass a full range of fillers for speeds of up to 400 bpm.
Furthermore the Swiftpack brand, formed in 1985, has established
itself as a leader within the electronic tablet and capsule counting
industries by having sold over 3,000 machines.
With hundreds of successful installations around the world, IMA
SAFE Nova and IMA SAFE Swiftpack have proven their ability as
line integrators of low and high speed packaging lines. Whether
integrating their own equipment or complementary machines,
their extensive machine knowledge and proven record of using the
latest technologies and methods positions them as the best source
to provide turnkey integrated bottle packaging systems.
IMA SAFE, YOUR ONE STOP SHOP
FOR THE PURCHASE OF COMPLETE
COUNTING LINES:
<
SLAT COUNTERS
<
ELECTRONIC COUNTERS
<
VISION SYSTEM COUNTING
<
ASSOCIATED EQUIPMENT:
FULL RANGE OF SLAT COUNTERS
DESIGNED TO MEET HIGH LEVEL GMP
AND FEATURING QUICK CHANGEOVER,
COUNT VERIFICATION AND COLOUR
TOUCHSCREEN OPERATOR INTERFACE
- unscramblers, bottle cleaning
- desiccant inserters, cotton inserters,
induction sealer
- cap, product and container elevators
- intermittent and rotary cappers
- product and bottle inspection
stations, quality check point stations,
checkweigher
- cartoning machines from  to 
bottles per minute
- wrapping machines, tray packers, casepacking machines, palletizers
- bench top counters for: laboratories,
quality control depts, pharmacies,
drug distribution centres, distributors
and hospitals
- turntable, conveyors
52
SLAT COUNTERS
IMA SAFE offers a wide range of slat counters to suit any
application. With a high level of GMP design, tool-free
changeover and controls incorporating product recipe and
changeover module, cleaning and changeover are quick and easy.
As the world leader in slat counting, IMA SAFE has successfully
designed slats to run all types of product shapes and counts with
a very high level of filling efficiency.
MERRILL HYBRID 72-39 UP TO 400 BPM OR 40,000 PRODUCTS
SL 16
UP TO 180 BPM OR 18,000 PRODUCTS
SL 39
UP TO 400 BPM OR 40,000 PRODUCTS
53
COUNTING EQUIPMENT
INTEGRATED SOLUTIONS: SOLVING SPACE
ISSUES WHILE MAINTAINING QUALITY
DESIGNED TO AVOID
CROSSCONTAMINATION, THE ONLY
MACHINE AVAILABLE ON THE MARKET
THAT PROVIDES HIGHLY ACCURATE
PRODUCT INSPECTION AND SINGLE
PRODUCT REJECTION.
ELECTRONIC COUNTING SYSTEMS
Infrared System: Products are counted thru the use of infrared
sensors. Electrostatic Field System (EFS): Products are not only
counted but examined in order to assure their geometric integrity.
A key aspect of IMA SAFE’s Electrical Counting Systems is the very
limited number of parts which are in contact with the product
The UNILINE and MONOPHARM systems, represent two
innovative solutions which integrate multiple functions into one
compact monobloc counting machine.
54
VISION COUNTERS
SWIFTVISION/SWIFTVISION II
TWIN SWIFTVISION/
SWIFTVISION II
SWIFTPHARM
TWIN SWIFTPHARM
MONOPHARM
UNILINE
UP TO 60 BPM OR 6,000 PRODUCTS
UP TO 120 BPM OR 12,000 PRODUCTS
UP TO 120 BPM OR 12,000 PRODUCTS
UP TO 240 BPM OR 24,000 PRODUCTS
UP TO 50 BPM OR 5,000 PRODUCTS
UP TO 150 BPM
The vision counter is based on the vibratory tray method of feeding
products to a counting head, but also adds the capability of product
inspection (one side) and rejection of non-conforming products.
This inspection and rejection capability is achieved through the
use of a vacuum drum that takes the products from the vibratory
trays and presents them to a high-resolution colour camera system
which controls of colour, area, perimeter and length.
CONTA 150
CONTA 300
UP TO 150 BPM OR 6,000 PRODUCTS
UP TO 240 BPM OR 12,000 PRODUCTS
55
TUBE FILLING
Located in Senago near Milan, IMA SAFE CO.MA.DI.S. is specialized
in the production of tube filling and closing machines for all types
of tubes, from aluminium to polythene, laminate and polyfoil ones
to meet the most stringent requirements of the pharmaceutical,
cosmetic and chemical industries. The acquisition of CO.MA.DI.S.,
in April 2001, has brought to IMA the long experience gained on
this production side; with more than 2,500 machines supplied
all over the world the know-how developed and the design
flexibility are the keys to manufacture high quality machinery and
provide customised solutions. The production range has been
always distinguished by a high degree of innovation, the design
and manufacturing characterized by the highest technological
standards, to assure high productivity coupled with flexibility and
reliability. The CO.MA.DI.S.. production program currently includes
14 different models in several versions, equipped with 1, 2 or 3
filling nozzles for a wide range of applications. Output up to 240
tubes/minute. The success of these tube fillers represents not only
the great experience gained in the field, but derives also from a
continuous co-partnership in the development with customers all
over the world.
56
CO.MA.DI.S. TUBE FILLING AND CLOSING
MACHINES ARE VERY EASY TO USE AND
CAPABLE OF HANDLING ALMOST EVERY
TYPE OF PRODUCTS SUCH AS GELS,
OINTMENTS, CREAMS, TOOTHPASTE,
GLUES, SILICON, IN DIFFERENT TYPE OF
TUBES. THE SEALING SYSTEMS VARY
ACCORDING TO THE TUBE TYPE HOT
JAWS OR HOT AIR SYSTEMS.
LOW SPEED SINGLE NOZZLE
MEDIUM SPEED SINGLE NOZZLE
HIGH SPEED MULTIPLE NOZZLE
- Semiautomatic tube filler
C630 UP TO 30 TUBES/MINUTE
- Semiautomatic/automatic tube filler
C945 UP TO 45 TUBES/MINUTE
- Automatic tube filler
C960 UP TO 60 TUBES/MINUTE
C970 UP TO 70 TUBES/MINUTE
- Automatic tube filler
C1090
UP TO 90 TUBES/MINUTE
C1110
UP TO 110 TUBES/MINUTE
C1090 SERVOMATIC UP TO 90 TUBES/MINUTE
- Automatic tube filler
CD150 UP TO 150 TUBES/MINUTE
CD180 UP TO 180 TUBES/MINUTE
CT240 UP TO 240 TUBES/MINUTE
57
CARTONING
Since the mid 1970’s IMA SAFE has had the reputation of innovator
in cartoning technology.
IMA SAFE cartoning machines are designed to run efficiently,
reliably, quietly and with fast changeovers. Maintenance needs are
minimised.
Each machine is designed to optimize valuable floor space and
innovative solutions, such as carton transport by way of belts, tuck
closing solutions and balcony construction are the result of IMA
SAFE’s focus on increasing production output.
Compact and versatile, IMA SAFE cartoning machines
ensure high operation standards and are suitable to flexible
packaging needs.
VALUE COMPETITIVE, FLEXIBLE, SAFE,
OPERATOR FRIENDLY AND COMPACT
CARTONERS
INTERMITTENT MOTION HORIZONTAL
CARTONERS
CONTINUOUS MOTION HORIZONTAL
CARTONERS
Several models of horizontal intermittent motion cartoners
providing cost efficient operation at speeds up to 190 cartons per
minute, compact layout and best ergonomics.
A series of cartoners offering best uptime for high speed packaging
lines up to 400 cartons per minute.
EASY
PG IC150
K150
A83E/EH
FLEXA
58
70 CARTONS/MINUTE
100 CARTONS/MINUTE
110 CARTONS/MINUTE
160 CARTONS/MINUTE
190 CARTONS/MINUTE
FLEXA
DYNAMICA
190 CARTONS/MINUTE
400 CARTONS/MINUTE
FEEDING SYSTEMS
Cost effective and flexible feeding systems are available which offer
a wide range of solutions for both pharmaceutical and cosmetic
products. Systems have been developed to facilitate modular
feeding concepts which are necessary to meet the market’s needs
as well as product variants which are increasing over time.
59
END-OF-LINE EQUIPMENT
IMA’s high quality standards also apply to the End of Line machines
making them ideal to complete all packaging lines produced within
the Group.
IMA SAFE Line has to date supplied over 6500 machines to various
sectors such as the pharmaceutical, cosmetic, tea, coffee, food,
confectionery and tobacco markets.
Almost 30 years of experience combined with the most advanced
research and manufacturing technology allow IMA SAFE Line to
offer specific solutions to the demands of overwrapping, stretch/
shrink wrapping, casepacking, traypacking and palletising.
OVERWRAPPING MACHINES
IMA SAFE Line can supply a wide range of machines in the
overwrapping field for the following applications:
- Single carton overwrapping machines
3791 SERIES  3701/3711/3721 SERIES  3705
FROM 25 TO 250 CARTONS/MIN.
- High quality single cosmetic carton overwrapping machines
3791U  AC 60  AC120
FROM 25 TO 120 CARTONS/MIN.
- Cartons collator overwrapping machines
3791AB  AC60  3711ABV
3786 SERIES  3703 SERIES  AF60
FROM 10 TO 100 BUNDLES/MIN.
60
IMA SAFE LINE MANUFACTURES A
COMPLETE RANGE OF ENDOFLINE
MACHINES AND CAN SUPPLY
TURNKEY SOLUTIONS.
STRETCHBANDING & SHRINK
WRAPPING MACHINES
SIDE AND TOP LOADING CASE PACKING
MACHINES
IMA SAFE Line has developed reliable solutions for the following
applications:
Even in this field IMA SAFE Line can offer innovative solutions
for the following applications:
- High speed collator stretch-banding machine for cartons
MS 300 SERIES UP TO 40 BUNDLES/MINUTE
MS 250 UP TO 60 BUNDLES/MINUTE
- Stretch-banding machine for naked blisters
MS 300 BLISTER UP TO 40 BUNDLES/MINUTE
- Bottle collator shrinkwrapping machines
MS 450+T450 UP TO 45 BUNDLES/MINUTE
- High speed bottle collator shrink-wrapping machines
3727 BAN UP TO 60 BUNDLES/MINUTE
- Side loading casepacking for cartons
CP18 UP TO 14 CASES/MIN.
CP28/48 UP TO 10 CASES/MIN.
CP38 UP TO 30 CASES/MIN.
CP50 UP TO 50 CASES/MIN.
CPM SEMIAUTOMATIC CASEPACKER
- Top loading casepacking for loose or bundled bottles
CPV15 UP TO 1520 CASES/MIN.
3754 UP TO 50 CASES/MIN.
61
END-OF-LINE EQUIPMENT
62
TRAYPACKING MACHINES
PALLETIZING MACHINES
IMA SAFE Line can also propose a full range of machines in this
market sector to cover the following applications:
To complete the packaging lines, IMA SAFE Line can supply solutions
to the following applications:
- Trayforming and filling machine for cartons
TP60 UP TO 60 TRAYS/MIN.
- Displaybox forming and filling machine for cartons, bottles, vials
and sachets with lid closing
FR30 UP TO 30 TRAYS/MIN.
- Individual palletizing machine
MINIFLEX UP TO 6 CYCLES/MIN.
2FPS UP TO 10 CYCLES/MIN.
FLEX PALLETIZER UP TO 15 CYCLES/MIN.
DEPALLETIZER UP TO 5 CYCLES/MIN.
INTEGRATED SYSTEMS FOR
CASEPACKING AND PALLETIZING
- Integrated side-loading case-packing and palletizing
CP18/28+FLEX UP TO 10 CASES/MIN.
CP18/28 + MINIFLEX UP TO 6 CASES/MIN.
- Integrated top-loading case-packing and palletizing
VERTICAL CARTOPALLET UP TO 7,5 CASES/MIN.
VERTICAL CARTOPALLET HIGH SPEED
UP TO 15 CASES/MIN.
63
IMA GROUP IN THE WORLD
IMA S.p.A.
ADMINISTRATION OFFICES
Via Tosarelli, 184
40055 Castenaso (Bologna) - Italy
Tel. +39 051 783111 - Fax +39 051 784422
IMA ACTIVE DIVISION
SOLID DOSE SOLUTIONS
Via I° Maggio, 14
40064 Ozzano Emilia (Bologna) - Italy
Tel. +39 051 6514111 - Fax +39 051 6514287
mktg.soliddose@ima.it
IMA KILIAN GmbH & Co. KG
TABLET PRESS MACHINES
Scarletallee, 11
D - 50735 Köln - Germany
Tel. +49 0221 717402 - Fax +49 0221 7174110
mktg.soliddose@ima.it
ZANCHETTA S.r.l.
POWDER HANDLING AND WASHING SYSTEMS,
GRANULATION EQUIPMENT
Via della Contea 24 - 55015 San Salvatore
Montecarlo (Lucca) - Italy
Tel. +39 0583 2171 - Fax: +39 0583 217317
mktg.soliddose@ima.it
IMA LIFE S.r.l.
ASEPTIC PROCESSING & FILLING SOLUTIONS
Ozzano Production Facility:
Via Emilia, 428/442
40064 Ozzano Emilia (Bologna) - Italy
Tel. +39 051 6514111 - Fax +39 051 6514821
mktg.filling@ima.it
Calenzano Production Facility:
Via Petrarca, 34/38/40
50041 Calenzano (Firenze) - Italy
Tel. +39 055 883231 - Fax +39 055 8879745
IMA EDWARDS
FREEZE DRYING SOLUTIONS
USA Regional Headquarters:
2175 Military Road - Tonawanda, NY 14150 USA
Tel. +1 716 695 6354
European Regional Headquarters:
Steenstraat 7 - Dongen, NE 5107, The Netherlands
Tel. +31 162 383 500
Asian Regional Headquarters:
101 Wangjing Lize Zhong Yuan, Chaoyang District
Beijing, China
Tel. +86 10 64399688
www.imaedwards.com
sales@imaedwards.com
64
IMA SAFE S.r.l.
PACKAGING SOLUTIONS
Via I° Maggio, 14
40064 Ozzano Emilia (Bologna) - Italy
Tel. +39 051 6514111 - Fax +39 051 6414743
mktg.packaging@ima.it
IMA SAFE LINE
END OF LINE SOLUTIONS
Via Romagnoli, 2
40010 Bentivoglio (Bologna) - Italy
Tel. +39 051 6642111 - Fax +39 051 6642255
imaeol@ima.it
CO.MA.DI.S. S.p.A.
TUBE FILLING MACHINES
Via Piemonte, 34
20030 Senago (Milano) - Italy
Tel. +39 02 99010284 - Fax +39 02 99010803
sales@comadis.ima.it
NOVA PACKAGING SYSTEMS Inc.
COUNTING EQUIPMENT
7 New Lancaster Road, Leominster, MA USA 01453
Tel. +1 978 537 8534 - Tool-Free 800 851 1518
Fax +1 978 840 0730
www.imanova.com
PRECISION GEARS Ltd.
THERMOFORMING AND CARTONING MACHINES
Corporate Office & Factory:
Plot No. R-677, MIDC T.T.C Indl. Area,
Thane Belapur Area, Rabale,
Navi Mumbai 400 701, India
Tel.: +91 22 67179191 - Fax: +91 22 27600888
sales@precisiongears-ima.com
SWIFTPACK AUTOMATION Ltd.
COUNTING EQUIPMENT
Swiftpack House, 3 Arden Road, Alcester,
Warwickshire B49 6HN
United Kingdom
Tel. +44 0 1789 400880 - Fax +44 0 1789 400780
sales@imaswiftpack.com
www.imaswiftpack.com
For information on the IMA subsidiaries
and sales offices, visit our website:
www.ima.it (contacts section)