report to the community - Sylvester Comprehensive Cancer Center
Transcription
report to the community - Sylvester Comprehensive Cancer Center
FALL 2003 REPORT TO THE COMMUNITY FISCAL YEAR 2003 J U N E 2 0 0 2 T H R O U GH M AY 2 0 0 3 Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 TABLE OF CONTENTS 1 MESSAGE FROM THE DIRECTOR 3 STORIES OF HOPE Cancer survivors reflect on how they are beating the odds. 7 EVE RYD AY H ERO ES The Sylvester family has changed the face of cancer care in South Florida. 9 ON THE FRONT LINE Message from the Scientific Director; Scientific Programs and Shared Resources facilitate discovery; Physicians and scientists join UM/Sylvester. 16 MILESTONES Looking back on the cancer center’s rich history; State-of-the-art radiation therapy and imaging services keep UM/Sylvester on the cutting edge. 18 IN THE NEWS The Braman Family Breast Cancer Institute, UM/Sylvester at Deerfield Beach, and a $10 million pledge from the Papanicolaou Corps for Cancer Research topped our news stories this past year. 19 MAKING A DIFFERENCE Message from the Chairman of the Board; Support for UM/ Sylvester comes in all shapes and sizes; Special donors continue to make a difference at the cancer center. 30 FACTS AND FIGURES Hospital and research financial profiles and clinical overview reveal a cancer center on the move. OUR MISSION We seek to reduce the human burden from cancer and other serious illnesses through research, education, prevention, and the delivery of quality patient care. OUR VISION UM/Sylvester will become a fully integrated program of patient care, education, and research with an international reputation for excellence. UM/Sylvester will provide new hope for cancer patients in our extended community, which includes South Florida, the southeastern United States, the Caribbean, and South America. UM/Sylvester will promote efficient, community responsive health care, and generate resources to sustain and enhance innovative cancer programs. OUR VALUES Excellence • Compassion • Respect • Discovery 10 Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER MESSAGE FROM THE DIRECTOR I t’s been a terrific year at the University of Miami Sylvester Comprehensive Cancer Center, one marked by notable accomplishments and festive celebrations. UM/Sylvester celebrated its 10th anniversary during this fiscal year, while the University of Miami School of Medicine and the Papanicolaou Corps for Cancer Research each celebrated their 50th. Looking back on the rich history of these organizations there is no doubt that they have left an indelible mark on our community, one that will continue to have a positive impact for years to come. We take our mission to reduce the human burden from cancer very seriW. Jarrard Goodwin, M.D., F.A.C.S. ously, and last January opened a satellite facility in Deerfield Beach. The success of UM/Sylvester at Deerfield Beach has made it increasingly evident that the demand for our expertise in the fight against cancer extends well beyond In January, UM/Sylvester will county lines. Forty percent of our patients live in Broward and Palm Beach counties, and having a significant presence there has allowed us to better serve kick off its comprehensive these communities. We are truly one community fighting cancer and by spreading our wings northward, our commitment has grown that much stronger. capital campaign. We plan UM/Sylvester has also embarked on a significant overhaul of our clinical and research infrastructure and launched an ambitious recruitment program. to invest $260 million to We are looking to expand our facilities and service capabilities in several areas to meet current and future growth. Research and clinical space renovation and significantly grow the cancer construction are in the advanced planning phase to allow us to pursue our aggressive recruitment goals. center over the next five years. For more than two years, we have worked diligently to reorganize the way we provide care and perform clinical research. We use a “site-based” approach to cancer detection and treatment. This means that multidisciplinary teams of highly trained physicians and scientists focus their attention on specific types of cancer, based on where the cancer starts in the body. With this unique approach, patients receive care from physicians who are not only cancer Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 1 MESSAGE FROM THE DIRECTOR specialists, but specialists in a particular type of cancer. With scientists particiSITE DISEASE GROUP LEADERSHIP pating in site disease groups, we have the opportunity to immediately transfer research findings to the bedside, or to the patient. This is a fundamental point O ur priority is to better serve our patients with complex medical needs. UM/Sylvester applies a targeted, “site- of distinction for UM/Sylvester, which is made possible because we are a university-based cancer center. based” approach to treating cancer. The In January, UM/Sylvester will kick off its comprehensive capital 13 site disease groups include: campaign. We plan to invest $260 million to significantly grow the cancer • Breast Cancer: Eli Avisar, M.D.; Joyce Slingerland, M.D., Ph.D.; Cristiane Takita, M.D. center over the next five years. This exciting capital campaign must raise $137 million from friends and supporters with matching contributions from • Colorectal Cancer: Michael D. Hellinger, M.D. the University of Miami and government resources. In fact, we are already • Eye Cancer: Arnold M. Markoe, M.D., Sc.D.; Timothy G. Murray, M.D., F.A.C.S closer to reaching that goal, having raised nearly $50 million during the • Gynecologic Cancer: Joseph A. Lucci III, M.D.; Aaron H. Wolfson, M.D. include an $11.5 million gift from the Sylvester family, a record-setting pledge campaign’s “quiet phase.” Some of our most significant commitments to date of $10 million from the Papanicolaou Corps for Cancer Research, and • Head and Neck Cancer: Donald T. Weed, M.D. $5 million from the Norman and Irma Braman Family Foundation, to create the Braman Family Breast Cancer Institute at UM/Sylvester. The dollars • Leukemia, Lymphoma, and Myeloma: Hugo F. Fernandez, M.D. raised will fund the recruitment of physicians and scientists, help us expand • Lung Cancer: Luis E. Raez, M.D., F.A.C.P.; Richard J. Thurer, M.D. our clinical areas, and enhance our research programs. • Melanoma and Related Skin Cancers: George W. Elgart, M.D.; Lynn G. Feun, M.D. We also plan to compete successfully for a core research support grant from the National Cancer Institute (NCI). All of these efforts combined— • Neurological Cancer: Deborah O. Heros, M.D.; Howard J. Landy, M.D. opening UM/Sylvester at Deerfield Beach, our clinical and research expan- • Orthopedic Cancer: Thomas H. Temple, M.D. as a comprehensive cancer center by the NCI, go hand in hand in helping to sion, recruitment efforts, the capital campaign, and the potential designation • Pancreatic and Other Digestive Cancers: Bach Ardalan, M.D.; Dido Franceschi, M.D. world-class care. W. Jarrard Goodwin, M.D., F.A.C.S. • Pediatric Cancer: Stuart R. Toledano, M.D. Director, UM/Sylvester • Prostate, Bladder, and Kidney Cancers: Mark S. Soloway, M.D. 10 2 achieve our many objectives as a university-based cancer center providing Q U EST Medical Director, UM/Sylvester at Deerfield Beach TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER STORIES OF HOPE B E AT I N G T H E O D D S For all the new tools and scientific discoveries, nothing more poignantly tells the tale of progress t h a n o n e p e r s o n ’s s t o r y o f b e a t i n g t h e o d d s . A n d a n o t h e r ’s . A n d a n o t h e r ’s . A n d a n o t h e r ’s . W ith each issue of Quest magazine we bring you a story of hope. It’s a story about the incredible strength of the human spirit and the true impact of scientific discovery. Generally, it’s a difficult story to imagine—families going about their business suddenly stopped in their tracks, derailed by a cancer diagnosis. But somewhere along their journey through the disease, they crossed paths with the physicians and scientists at UM/ Sylvester. Together they fought the battle with an impressive arsenal of tools—some from the laboratory, some from within. And together, they are winning. The following article is an update on the extraordinary people we’ve profiled in Quest in the last two years. Today, they face life with a renewed commitment to making the most of every moment and making a difference for others who walk in their shoes. These are the people who remind us why we are here. They are the remarkable individuals who help us remember that no effort is too small in the search for a cancer cure. Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 3 STORIES OF HOPE M O T H E R F I N D S H O P E I N E X P E R I M E N TA L T R E AT M E N T W hen K E R R I E B E S T (Quest, Summer 2003) learned from Mark Goodman, M.D., an associate professor of hematology-oncology at the University of Miami Sylvester Comprehensive Cancer Center, that the lower back and abdominal pains she had been experiencing on and off for more than a year were a result of multiple myeloma, she knew she had to be strong. But, after an initial course of oral chemotherapy with promising results, disaster struck. Her partner of seven years, Charles, died suddenly, leaving her to face the disease and care for her two children alone. Best’s condition took a turn for the worse, landing her in the hospital, first in her home in Antigua, then in Miami. It was a difficult time, Goodman says, further complicated by the fact that Best’s disease failed to respond to three standard regimens of chemotherapy. So, Goodman explored the possibility of enrolling Best in a trial that “In less than six months, the tested the effectiveness of Arsenic Trioxide and vitamin C in destroying myeloma cells that have become resistant to standard chemotherapy. amount of myeloma in Kerrie’s The clinical trial, the only one of its kind in the United States, is the brainchild of a team of UM/Sylvester scientists and physicians led by Kelvin P. bone marrow decreased Lee, M.D. For Best, the results were promising. “In less than six months, the amount of myeloma in Kerrie’s bone marrow, as well as the protein that is a notably. Her health improved marker for the disease, decreased notably,” Lee says. And, he adds, “Her health improved significantly.” significantly.” For a course of five weeks, Best received intravenous infusions daily, with two weeks off at the end of the five-week period. That’s when she’d return to Kelvin P. Lee, M.D. Antigua to be with her children before flying back to Miami to repeat the routine. The course of B R A I D F E E L I N G G R E AT; S E E S E V E RY D AY A S A G I F T treatment lasted for six, sevenweek sessions. wenty-eight months since taking a single intravenous dose of the investigaThough Best’s test results tional drug Bexxar, K A T H Y B R A I D (Quest, Summer 2002) is feeling still showed elevated protein great. She isn’t showing any signs of recurrence of the low-grade lymphoma levels after the 42-week treatment that’s been a part of her life since 1995. It is the longest period of quiescence period, her condition was much she’s experienced in seven years. improved. She has returned “I’m doing wonderful. I just turned 51, my job is still great, and I thank to Antigua and now comes to God every day,” she says enthusiastically. “Every day is a gift—whether you’re Miami once each month for two years old or 100 years old. I realize that more and more.” intravenous chemotherapy. That’s the kind of positive attitude that boosted Braid last October when She was recently approved to her husband of almost 24 years, Kenny, suffered a mild heart attack. After a enroll in a new trial, one she brief hospitalization and three weeks at home, Kenny is back to work and takhopes will put an end to her ing part in a cardiac rehabilitation program. ordeal. T 10 4 Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER STORIES OF HOPE LINHART USES MEDIA TO PROMOTE CLINICAL TRIAL A N G E L A L I N H A R T has become a celebrity of sorts. Three years since doctors at the University of Miami Sylvester Comprehensive Cancer Center declared her cancer-free, the 33-year-old “As long as you’ve got faith and wife and mother has been telling her story. She’s been featured in Quest (Fall 2001), the Sun-Sentinel your health, you can get through (December 2001) and Woman’s World (October 29, 2002). She even addressed an audience of more everything else.” than 600 physicians and medical professionals at a conference promoting Bexxar, the investigational Angela Linhart drug that saved her life. Linhart doesn’t have a lot of free time these days. As the office manager at a local elementary school and the mother of an active six-year-old girl, Linhart is on the go. Even so, she never shies from an opportunity to tell the story of how doctors at UM/Sylvester used Bexxar to almost miraculously put into remission the stage four, non-Hodgkin’s lymphoma she had been diagnosed with about a year after the birth of her daughter, Kourtney. “The more I can do to get the word out, the more I can help advance the clinical trial,” she says. But that’s not all Linhart talks about when she gets the chance. She also encourages people to appreciate life a little bit more and worry about everything else a little bit less. “When you’re fighting for your life, that’s big,” Linhart says. “As long as you’ve got faith and your health, a roof over your head, and food on the table, you can get through everything else.” She also reminds her audiences that every person needs to take charge of his or her own health care. Had Linhart not taken matters into her own hands after a previous doctor gave up all hope, she never would have found UM/Sylvester, or the clinical trial that turned her life around. “We didn’t panic too much,” she says. “With evThese days, Linhart’s appointerything we’ve been through, we knew we just had to ments at UM/Sylvester come only deal with it and get on with our lives.” every six months. Though her And that’s just what she’s done. Braid has joined a gym and is enjoying lengthy remission is very encoura new phase of life. With one son now in college, and a second in seventh aging, Linhart doesn’t devote time grade, Braid and her husband are finding themselves in “a whole different to thinking about her disease. Her ballgame,” and enjoying every minute. thoughts are focused on more While the cancer is important, she says it’s not the most important thing. positive things, like the dollhouse “It’s a part of my life; it just doesn’t rule it.” she’s building with her daughter. After so many rounds of chemotherapy, Braid still is amazed that a single “I really believe in UM/Syldose of the experimental drug could produce such remarkable results. “We’re vester,” Linhart says.“I will never just happy and grateful,” she says. “We’re blessed.” go anywhere else.” Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 5 STORIES OF HOPE SURVIVOR SHIFTS FROM RECOVERY TO ADVOCACY T hirty-eight-year-old M A R T Y M A S H (Quest, Spring 2002), a tongue cancer survivor, has had a change in direction. He’s not all about recovering these days. Instead, he’s focused on helping others deal successfully with the unique challenges that come with head and neck cancer. He says, quite simply, “I’m doing great,” and his doctor agrees. Truthfully, Mash isn’t thinking about himself anymore. When he’s not busy at work as a computer entrepreneur in the business he runs with his father, Mash is leading UM/Sylvester’s head and neck cancer support group, offering useful tips and friendship to survivors online, and participating in an Oxford University research study to find new cancer drugs. He’s also serving as the southeast regional advocate for the Yul Brynner Head and Neck Cancer Foundation, and as a lay consultant to the American College of Surgeons Oncology Group regarding new surgical protocols for head and neck cancer. Mash is the consumer member of the Specialty Board on Swallowing and Swallowing Disorders, which was created by the American Speech-Language-Hearing Association. “It’s therapy for me,” says Mash. “Part of it is a debt of gratitude, but the “From all this, I’ve learned rest is something I need to do for myself and for others.” While his speech is not what it once was due to the cancer, the clarity and control with which he speaks to live for today.” are remarkable. “The way I speak,” he says, “ is a reminder to others.” Mash admits he’s not the same person he was before the cancer. He gets Marty Mash tired at the end of the day and has had to make some adjustments at work. But those adjustments, more email than phone communications, for example, seem minor to the hurdles he already has cleared. Today, Mash lives life differently. He no longer says, “I’ll do it tomorrow,” and doesn’t take anything for granted. “From all this, I’ve learned to live for today,” he says. P AT H O F L I G H T C E L E B R A T I O N 2004 Survivors’ Day celebration scheduled for March 20 at Flamingo Gardens in Davie, Florida. Fittingly themed, “A Celebration of Life,” P lease join us as we honor our loved ones who have been af- more than 500 guests will join in the family picnic including cancer fected by cancer. On December 8, we will remember those who survivors, their loved ones, and UM/Sylvester cancer specialists. have passed and celebrate those who have survived. Scheduled for “Cancer Survivors’ Day is a truly moving and symbolic event that 7 p.m., the “Path of Light” celebration will reflect the human spirit’s shows the world that life after a cancer diagnosis can be a reality,” ability to cope and bring together all of us who are tied by the common says W. Jarrard Goodwin, M.D., F.A.C.S., director, UM/Sylvester. bond of cancer. On that day, please light a white taper—wherever you are—and know that we are one in spirit. UM/Sylvester’s 2004 Survivors’ Day celebration will begin at 10 a.m. at Flamingo Gardens, a 60-acre botanical garden and wildlife sanctuary in southwest Broward County. Along with a picnic-style luncheon, S U R V I V O R S ’ D AY E V E N T P R O M I S E S A M O V I N G C E L E B R AT I O N O F L I F E the celebration will feature a performance by Bailey, a brain cancer survivor who has outlived all projections as he travels the world inspiring and entertaining thousands of listeners touched by cancer. N 10 6 ationally acclaimed singer, songwriter, and cancer survivor David M. Bailey will be the featured performer at UM/Sylvester’s Q U EST For more information, contact Carthy Thomas, community relations manager, at 305-243-4071. TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER EVE RYD AY H ERO ES T H E S Y LV E S T E R F A M I LY: CHANGING THE FACE OF CANCER CARE When Harcourt Sylvester, Jr., first pledged $27.5 million to the University of Miami in 1986, in honor of his parents, he probably never imagined the way his family’s gift would change the face of cancer care in South Florida. Harcourt Sylvester, Jr. and his daughters, Laura Cameron and Jayne Malfitano “I think he dreamed the cancer center would be wonderful, but I don’t think any of us could have imagined what it would become.” Jayne Malfitano Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 7 EVE RYD AY H ERO ES I “ think he dreamed the cancer center would be wonderful,” says daughter Jayne Malfitano, “but I don’t think any of us could have imagined what it would become.” Malfitano was in her early 30s when Sylvester made the donation through “Thanks to the extraordinary the family foundation. The foundation was funded from the sale—to the support of the Sylvester family, British firm Hawker-Siddely—of the family business, Fasco, Inc., a manufacturer of a variety of fractional horsepower motors and a wide range of electri- our cancer center is an uplifting and special place.” cal products for the building industry. While she and her sister, Laura Cameron, and their now deceased brother were interested in the cause, their father was passionate. His greatest excitement came, Malfitano says, when the W. Jarrard Goodwin, M.D., F.A.C.S. architects turned their attention to the building’s exterior design. The welcoming, uplifting environment that resulted from Sylvester’s keen input, including the courtyard and beautiful archway, continues to provide a tremendous benefit for the patients, visitors, and staff of the cancer center. The initial multimillion dollar donation made through the Harcourt and Virginia Sylvester Foundation of Palm Beach was like none other in the University of Miami’s history. But the family’s commitment to cancer care didn’t end there. In 1988, the family added another $5 million to their original pledge to help fund the construction and maintenance of what would become the University of Miami Sylvester Comprehensive Cancer Center. Having seen his grandchild survive cancer, Sylvester was later moved to do something more. He pledged an additional $5 million to create a cancer research floor in the Batchelor Institute for Children’s Research at the University of Miami School of Medicine. Recently, the Sylvester family contributed an additional $11.5 million 10 8 Q U EST to UM/Sylvester’s capital campaign, which means that the Sylvester Foundation has contributed or pledged more than $50 million to fund programs in the University of Miami School of Medicine. The Sylvester Foundation was recently inducted into the University’s new Millennium Society. “Thanks to the extraordinary support of the Sylvester family, our cancer center is an uplifting and special place,” said UM/Sylvester director, W. Jarrard Goodwin, M.D., F.A.C.S. Along with the Sylvester family’s generous financial support, their input and guidance over the years have been important factors in the continued growth and success of the cancer center. Today, Malfitano participates actively on the UM/Sylvester Board of Governors and is a member of the Marketing Committee of the Board. Last March, Sylvester and his daughters were on stage for the ribbon cutting ceremony to mark the opening of UM/Sylvester at Deerfield Beach, a 10,000-square-foot satellite facility located on the corner of I-95 and S.W. 10th Street, on the county line. It was an important day for the family, who all live nearby in Palm Beach County. Jayne and Laura are honored to have the torch passed to them and to further help the cancer center’s ability to positively impact the South Florida community, and indeed the entire cancer initiative. “My father feels a great connection with all the people he comes in contact with at UM/Sylvester, and that inspires him to do more,” says Malfitano. “He has always been so understated; he just wants to make a difference.” TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER ON THE FRONT LINE MESSAGE FROM THE SCIENTIFIC DIRECTOR R esearch is curing cancer, and to further achieve that goal, the University of Miami Sylvester Comprehensive Cancer Center continues to build upon its excellent scientific programs already in place. We are expanding our portfolio of clinical trials and developing new multidisciplinary initiatives and site disease groups. What’s more, these efforts extend across departmental lines, which will allow us to provide state-of-theart care and conduct innovative clinical research. The five long-standing, multidisciplinary scientific programs within UM/Sylvester afford unique training opportunities for our residents and fellows and include Tumor Cell Biology, Tumor Immunology, Viral Oncology, Cancer Prevention and Control, and the Clinical Oncology Research Program. Joseph D. Rosenblatt, M.D. Research breakthroughs that will result in new types of treatment are on the horizon. Theodore J. Lampidis, Ph.D., together with Luis E. Raez, M.D., F.A.C.P., is developing new approaches to lung cancer. Khaled Tolba, M.D., continues his research efforts in developing immune therapy approaches to fight cancer. Izidore Lossos, M.D., focuses on lymphoma and has already identified two genes that appear to be very important prognostic indicators in large cell lymphoma. UM/Sylvester is especially invested in the development of home grown clinical trials based on science and technology developed at the University of Miami. We have seen a steady increase in National Cancer Institute (NCI) funding for research at UM/Sylvester during fiscal year 2003, from $10.2 million in 2002 to $10.8 million in 2003. And, since research is at the heart of UM/Sylvester’s mission, this increase in funding will drive advancements that can be moved from the laboratory to the patient’s bedside (known as translational research) more quickly than ever before. Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 9 ON THE FRONT LINE Recruiting prominent clinical researchers to our already distinguished faculty remains a primary focus. UM/Sylvester has already recruited Research is curing cancer and world-renowned breast cancer physician-scientist Joyce Slingerland, M.D., Ph.D., from the University of Toronto, to direct the Braman Family Breast the University of Miami Sylvester Cancer Institute at UM/Sylvester. Rakesh Singal, M.D., M.R.C.P., joined UM/Sylvester this year as an associate professor of medicine in the Division Comprehensive Cancer Center of Hematology-Oncology, from Louisiana State University. A hematologist-oncologist and accomplished molecular biologist, Singal has had a continues to build upon its distinguished career studying gene regulation in prostate and other genitourinary tumors. excellent scientific programs UM/Sylvester currently plans to recruit five additional senior and 25 junior researchers. Each will have significant programmatic involvement already in place. within the five scientific programs. In addition, UM/Sylvester has added new research space, including newly remodeled floors as well as administrative space, to accommodate these additional physicians and scientists. Under the leadership of UM/Sylvester Director W. Jarrard Goodwin, M.D., F.A.C.S., and with the full support of our trustees and dedicated philanthropists in the community, we are well on our way to becoming a world-class cancer center and achieving NCI designation. We have embarked on an ambitious program of scientific and clinical expansion that will transform UM/Sylvester into one of the premier cancer centers in the nation. Joseph D. Rosenblatt, M.D. Scientific Director, UM/Sylvester 10 Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER ON THE FRONT LINE SCIENTIFIC PROGRAMS, SHARED R E S O U R C E S F A C I L I TAT E D I S C O V E R Y S cientists at the University of Miami Sylvester Comprehensive Cancer Center are grouped into five multidisciplinary scientific programs— Tumor Cell Biology, Tumor Immunology, Viral Oncology, Cancer Prevention and Control, and the Clinical Oncology Research Program. These scientific programs not only address important aspects of the cancer challenge, they reflect UM/Sylvester’s strengths and priorities as a research institution. Nine shared research resources are available to all UM/Sylvester members and provide access to technologies, products, services, and expertise that facilitate interaction between physicians and scientists and enhance scientific Xiadong Wu, Ph.D., uses BAT to deliver radiation with productivity. unsurpassed accuracy. A brief summary of UM/Sylvester’s scientific programs and shared research resources follows. NEW DISCOVERY SHOULD ENHANCE EFFECTIVENESS OF CHEMOTHERAPY C urrent cancer chemotherapy treatment works by attacking rap- the slow growing tumor cells take up more 2-DG than the slow grow- idly dividing cells. Fortunately, most normal cells in the body (e.g., ing normal cells and consequently starve to death. organ tissues such as the lung, liver, etc.) are slow dividing, meaning they typically are not affected by chemotherapy. Since chemotherapy does not attack slow dividing cells, it also “Under low oxygen conditions or hypoxia, tumor cells need to burn more sugar to supply them with the necessary energy to do all of the things required in the cell,” explains Lampidis. does not affect the slow growing parts of a tumor, which allows these Moreover, hypoxic conditions do not allow tumor cells to use other cells to withstand such treatment once the rapidly dividing cancer energy sources such as fats or proteins, which normal cells can use cells have been killed off. This means that although the growth of the when oxygen is present. This fundamental difference in metabolism overall tumor can probably be controlled with chemotherapy meth- opens a window of selectivity that can be exploited by using inhibitors ods, the cancer is not eliminated or cured completely. of glycolysis such as 2-DG, adds Lampidis. Theodore J. Lampidis, Ph.D., a scientist in the Tumor Cell Biology “When a hypoxic tumor cell’s usage of glucose is blocked with Program at UM/Sylvester, has discovered one way to attempt to tackle 2-DG it dies, whereas a normal cell that is treated similarly can use this problem. He has found that since the slow dividing cells located the other sources of energy to survive,” he says. “Combining 2-DG in the middle of the tumor are growing under low oxygen conditions (which targets the slow growing hypoxic cells) with standard chemo- (hypoxia), they differ in their metabolism of glucose from the normal therapeutic agents (that attack the rapidly dividing aerobic cells) should cells in the body. To exploit this difference, he has shown that by sim- increase the overall effectiveness of cancer chemotherapy.” ply using a false sugar—2-Deoxyglucose (2-DG)—instead of glucose, Q U EST The first clinical trials of this treatment will be available soon. TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 11 ON THE FRONT LINE SCIENTIFIC PROGRAMS TUMOR CELL BIOLOGY PROGRAM Program Leader: Kermit L. Carraway, Ph.D. aining a better understanding of the mechanics of cancer cell biology through cutting-edge research is just one of the objectives of the Tumor Cell Biology Program. The ultimate goal of the program is to develop opportunities for novel clinical applications. Much of the work conducted within this program examines how genetic information in cells is translated into functional proteins and how tumor cells interact with other cells and their environment—ultimately helping scientists better understand the biology of cancer, cell proliferation, and metastasis. Individual research within this program ranges from gene therapy to the ultrastructural analyses of protein, but all of the investigators are involved in breakthrough research using the developing methods of molecular biology and cell structural analyses to ask questions of importance to tumor cell biology. Tumor cell biology scientists also are examining how signaling pathways and molecules transmit and integrate information, which determines cell behavior and function. By better understanding how normal tumor cells behave, UM/Sylvester scientists can determine whether tumor cell biology can be targeted to combat cancer. G 10 12 Q U EST TUMOR IMMUNOLOGY PROGRAM Program Leader: Diana M. Lopez, Ph.D. he Tumor Immunology Program investigates the biology of the immune system as it relates to the development and potentially the treatment of cancer. Currently, the research conducted varies widely—from measuring breast cancer patients’ immune system response T William J. Harrington, Jr., M.D. to psychosocial interventions such as group therapy and stress reduction, to the design of effective vaccines to fight various human cancers, to the use of stem cell and bone marrow transplantation. Through ongoing research, investigators are gaining a better understanding of the mechanisms underlying the activities of innate and adaptive immune cells, novel aspects of stem cell biology and bone marrow transplantation, the role of T cells in the host defenses against tumors, and mechanisms of tumor evasion of the immune system. Scientists are working to devise novel immunotherapeutic protocols for human cancers. VIRAL ONCOLOGY PROGRAM Program Leaders: William J. Harrington, Jr., M.D. Antero G. So, M.D., Ph.D. he Viral Oncology Program is committed to developing and implementing novel therapeutic strategies for certain viral diseases and cancers. Program investigators have discovered that although several forms of lymphoma and leukemia do not respond to conventional chemotherapy, they are remarkably sensitive to antiviral therapy. Bench research conducted by members of the Viral Oncology Program has already translated into new clinical trials. The program also develops physician-scientists through a National Cancer Institute-sponsored training grant in viral oncology. The program’s scientists also conduct clinical and basic research to examine the cellular events that occur during the process of disease development (pathogenesis) due to oncogenic viruses such as EBU, HHV8, human T-cell leukemia viruses, and mechanisms underlying the development of malignancies in AIDS patients. T CANCER PREVENTION AND CONTROL PROGRAM Program Leader: Michael H. Antoni, Ph.D. ajor research efforts by the Cancer Prevention and Control Program include work in identifying predictors of tobacco use in adolescents; understanding the ethnic differences in genetic anomalies connoting risk for certain cancers; raising awareness of risk behaviors such as sun exposure that are associated with the high incidence of M TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER ON THE FRONT LINE cancers in Florida; assessment of quality of life among persons who have been treated for breast or prostate cancer and for those who have become long-term survivors of cancer; and testing the effects of stress management intervention on psychosocial, endocrine, and immune system functioning in persons recently diagnosed and treated for early stage breast or prostate cancer, as well as those at risk for AIDS-related cancers such as cervical cancer. Other investigations focus on differences in the incidence of a variety of cancers among the major ethnic groups residing in Florida, on developing culturally competent outreach programs to Hispanic populations, and implementing the most effective cancer control strategies in the South Florida population. The projects currently being conducted within this program vary sub- stantially. Some are purely behavioral or psychosocial in their aims; others examine neuroendocrine and immunological mechanisms relevant for disease promotion and/or progression. CLINICAL ONCOLOGY RESEARCH PROGRAM Program Leaders: Joseph D. Rosenblatt, M.D. Kelvin P. Lee, M.D. developing effort at UM/Sylvester, the Clinical Oncology Research Program is designed to specifically focus on translational and clinical research in relation to cancer prevention, diagnosis, and treatment and often collaborates with the four other scientific programs to ensure timely translation of basic science and breakthroughs to the patient’s bedside. Major program themes include: cellular therapy, gene A therapy, developmental therapeutics, molecular targets/prognostic factors/ pharmacogenetics, and clinical trials. These efforts link UM/Sylvester’s basic science discoveries to the bedside and facilitate the conduct of clinical trials to gain insights into cancer biology. SHARED RESOURCES Cell Purification and Banking Facility Clinical Research Services Resource DNA Core Facility Flow Cytometry Resource Gene Knockout and Transgene Facility Histology Research Lab Core Imaging and Molecular Core Molecular Analysis Core Protein Analysis Facility UM/SYLVESTER SCI ENTI STS IDENTI FY NEW H O D G K I N ’ S D I S E A S E T R E AT M E N T S cientists at UM/Sylvester have developed a new technique to of the Tumor Immunology Program, and has been licensed for use the immune system to attack tumor cells. This new treat- production by Seattle Genetics. It is meant for patients who do not ment identifies a protein on the surface of Hodgkin’s lymphoma cells, respond well to traditional treatments for Hodgkin’s disease, which called CD30, and labels CD30 with an antibody thereby targeting the include chemotherapy, radiation therapy, and bone marrow trans- lymphoma cells for destruction. plants. Unlike chemotherapy, patients treated with SGN30 do not “We have cells in the immune system that can recognize and lose their hair and experience fewer side effects. destroy cells that have been labeled with an antibody that earmarks Patients are enrolled in phase II clinical trials testing SGN30 at those cells for destruction,” says Joseph D. Rosenblatt, M.D., scien- UM/Sylvester and at six other medical centers nationwide. It has tific director at UM/Sylvester. already been administered to these patients at UM/Sylvester by Hugo The discovery of the drug, called SGN30, resulted in the develop- Fernandez, M.D. ment of a monoclonal antibody. Because it is an immunological treat- “CD30 is also seen in lymphoma and myeloma and may poten- ment, scientists expect fewer side effects than with traditional tially be useful in the treatment of those types of tumors as well as chemotherapy. “This type of treatment represents a much more intel- Hodgkin’s disease,” says Fernandez. ligent approach to cancer,” says Rosenblatt. SGN30 was developed by Eckhard Podack, M.D., Ph.D., chairman of microbiology and immunology at UM/Sylvester and member Q U EST The phase II portion of the trial with a fixed dose (when the dose from phase I is used for lymphoma patients to monitor the efficacy of the drug in the disease) will be available soon. TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 13 ON THE FRONT LINE SEVERAL NEW PHYSICI ANS AND SCIENTI STS JOIN UM/SYLVESTER TEAM R ecruiting prominent clinical researchers to our already distinguished faculty remains a primary focus at UM/Sylvester. The magnitude of this recruitment effort is so great, in fact, that 10 physicians and scientists have already joined UM/Sylvester during FY 2003, while many more have been recruited and will be featured in the next issue of Quest. J oining UM/Sylvester as an assistant professor of biochemistry and molecular biology, Terace M. Fletcher, Ph.D., comes to the cancer center with seven years of experience in cancer research as a post-doctoral fellow at the Cancer Therapy and Research Center Institute for Drug Development in San Antonio, Texas (headed by oncologist Daniel Von Hoff, M.D.) and as a staff scientist at the National Cancer Institute. As a basic scientist, Fletcher’s research interests include studying the chromosomal structure called the telomere. The telomere, located at the chromosome terminus, protects DNA and regulates cell growth. According to Fletcher, genomic instability caused by telomere disruption can result in key genetic alterations and subsequent cancer transformations. Experimental evidence suggests that telomeres of cancer and normal cells have architectural distinctions. However, the structural details of the telomere are largely unknown. “Telomeric assemblies found exclusively in cancer cells would present a set of novel chemotherapeutic targets,” says Fletcher. “The goal of our laboratory is to explore the relationship 10 14 Q U EST Terace M. Fletcher, Ph.D. Elizabeth Franzmann, M.D. between specific telomeric higher-order configurations and functions such as chromosome maintenance.” Fletcher holds a Ph.D. in biochemistry from the University of Texas Health Science Center. cation at the University of California at Los Angeles, where she subsequently received her medical degree. She completed her otolaryngology residency and head and neck surgical oncology fellowship at the University of Miami. “Working with a great team is what makes combining a research and clinical career possible,” says Franzmann. J oining UM/Sylvester as an assistant professor of otolaryngology, Elizabeth Franzmann, M.D., is interested in all aspects of prevention, diagnosis, and treatment of head and neck cancer and will combine her surgical practice, where she works closely with residents, with her research interests. Franzmann is studying the role of the CD44 family of molecules in head and neck cancer. CD44 molecules are involved in normal cell function. In some tumor cells CD44 molecules are altered and seem to be involved in uncontrolled growth and migration. Franzmann completed her basic science medical school education at Albert Einstein College of Medicine in New York, finishing her clinical edu- C armen Solorzano, M.D., joins UM/Sylvester as an assistant professor of surgery. She comes to the cancer center from the University of Texas MD Anderson Cancer Center where she completed her surgical oncology fellowship training. Solorzano says one of the primary reasons she wanted to join UM/Sylvester was the opportunity to treat patients of varying geographic and ethnic backgrounds. Solorzano plans to explore better treatments for patients with pancreatic and endocrine cancers. Her prior TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER ON THE FRONT LINE Carmen Solorzano, M.D. May Abdel-Wahab, M.D., Ph.D. laboratory research examined mouse models for pancreatic cancer. “I will also be looking at gene expression profiles in patients with thyroid cancer to better diagnose and treat them,” she adds. Solorzano’s other research interests focus on rapid intraoperative assays to measure hormones in patients with overactive parathyroids and insulin tumors of the pancreas. In these patients, surgical removal of the tumors (overproducing hormones) is necessary, and these assays assure that all overactive tissue has been removed. Solorzano attended medical school and completed her residency in general surgery at the University of Florida in Gainesville. sistant professor of radiation oncology. Abdel-Wahab trained and held various affiliate and adjunct positions in the radiation oncology department at the University of Miami. At UM/Sylvester, Abdel-Wahab will continue to work in the areas of prostate cancer and genitourinary cancers. Her main interest is in the continued study of vitamin D and androgen receptors in prostate cancer. She also continues her research on the effect of androgen receptor transcriptional integrity on outcome in Radiation Therapy Oncology Group (RTOG) study patients. Results of a phase II vitamin D study headed by Abdel-Wahab, funded by the VA Research Service, were presented at the American Society of Clinical Oncology (ASCO) this year. It suggests a possible benefit in prevention of recurrence post-prostatectomy. Abdel-Wahab is now preparing the next step—a study in that group of patients to determine whether vitamin D will enhance the results of radiation in these patients. Other re- M ay Abdel-Wahab, M.D., Ph.D., joins UM/Sylvester as an associate professor of clinical radiation oncology from the Miami Veterans Administration Medical Center where she was a research scientist and an as- Q U EST search interests include the use of a novel radiosensitization developed by Sheldon Greer, Ph.D., at the University of Miami. Abdel-Wahab has had extensive training that includes two fellowships and two residencies at the Crawford Long Hospital of Emory University in Atlanta (high dose rate brachytherapy), National Cancer Institute of Cairo University in Cairo, Egypt (a recognized leader in bladder cancer treatment), and the University of Miami. She also has a doctorate from Cairo University and received specialized training in gamma knife techniques at the University of Pittsburgh and seed implant training at the Seattle Prostate Institute. RECENT RECRUITS 2002-2003 T he following six physicians and scientists were featured in the summer issue of Quest. Izidore Lossos, M.D. Denise Pereira, M.D. Rakesh Singal, M.D., M.R.C.P. Oluwatoyin Shonukan, M.D. Joyce Slingerland, M.D., Ph.D. Khaled Tolba, M.D. TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 15 MILESTONES June 1992 1992 1993 Sylvester Comprehensive Cancer Center facility is dedicated and joined with the University of Miami Hospital and Clinics to become UM/Sylvester. Jay Weiss becomes chairman of the board of UM/Sylvester. W. Jarrard Goodwin, M.D., F.A.C.S., and David Stansberry are recruited to provide faculty and administrative leadership. LOOKING BACK, MOVING FORWARD T he transformation of the University of Miami Sylvester Comprehensive Cancer Center into South Florida’s premier cancer center can be traced to its ability to cope with rapidly changing environments and situations. This history of flexibility and adaptability has enabled UM/Sylvester to grow and accomplish significant milestones in a little more than a decade of operation. Two months after its doors opened in June 1992, UM/Sylvester suddenly found itself confronting a formidable adversary that put the facility’s continued existence into question. On August 24, 1992, a massive category four hurricane named Andrew made landfall in South Florida. One UM/Sylvester employee present that day was Tom Cunningham, now associate administrator. “The memory of that hurricane’s humbling power will always be indelibly etched in my mind,” Cunningham says. “As it turned out, Andrew reserved the bulk of its fury for the Homestead area, and UM/Sylvester weathered the storm sustaining fairly minor damage.” Having survived an encounter with nature at its most unforgiving, UM/Sylvester returned to being 10 18 16 Q U EST buffeted by man-made storms. “Anytime you create a facility like UM/Sylvester, there are going to be growing pains,” Cunningham says. “Frankly, the first months of operation were a bit troubling—operating rooms, for example, were not running anywhere near full capacity. Although those kinds of issues are to be expected, they’re still very tough to deal with.” Eleven years later, inpatient admissions have grown by more than 18 percent in the past four years alone, and surgeries have increased by more than 30 percent. “We’ve grown a lot since the 1990s, and we’ve reached capacity now. Unless we increase our bed count and number of surgery suites, we won’t be able to keep up with our growing volume,” observes hospital administrator David Stansberry. The hospital needs to be expanded to meet the needs of the ever-growing patient population. “We’re working to make the most efficient use of space,” says Stansberry. “We have a rather significant renovation project underway, and we’re almost always moving departments around to accommodate our patients.” One way that UM/Sylvester may expand its inpatient and surgical capacity is by moving the Courtelis Center from its current location to another floor of the hospital. The Courtelis Center, which opened in 1995, provides counseling services, patient education and support groups, medication consultation, patient library/learning center, and many complementary therapies for mind and body healing. “Patients look to us for innovative new treatments and programs,” says Stansberry. “The Courtelis Center is one of our most valuable resources. It’s but one aspect of UM/Sylvester that makes us unique.” In the near future, the Comprehensive Treatment Unit (CTU) is one of the areas that will be expanded in addition to the clinical pharmacy area, which is also running near capacity. “As the number of chemotherapy treatments increases, we have to expand our capability in pharmacy as well,” Stansberry adds. To address these issues, six additional physicians will be hired to the unit by year-end. “We also have a very large research enterprise here within the medical school. An ambitious research pharmacy expansion is underway that will increase that area’s capacity four-fold.” Not all of the improvements are of the bricks-and-mortar variety, however. TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER MILESTONES 1995 2001 2003 The Courtelis Center for Research and Treatment in Psycho-Social Oncology is founded. Joseph D. Rosenblatt, M.D. arrives as scientific director. UM/Sylvester at Deerfield Beach opens. The manner in which UM/Sylvester serves its patients is also being revamped. “One of the concerns has been that our services are lacking during nighttime hours,” says Cunningham. “Patients can’t get x-rays or blood work done, and the pharmacy is closed.” Consequently, UM/Sylvester has begun to add clinicians and treatment areas in order to provide full, roundthe-clock care. “Now we offer a full range of services providing 24-hour care evenings, nights, and weekends.” Clearly these are busy, exciting times for UM/Sylvester, a facility tested by the force of nature and the needs of the South Florida community it serves. “We are committed to ensuring that the cancer center continues to provide the highest quality health care to patients from our region,” Stansberry says. S TAT E - O F - T H E - A R T I M A G I N G S E R V I C E S I n keeping with its dramatic growth, UM/Sylvester continues to offer state-of-theart diagnostic imaging and cancer treatment. Among the services offered at UM/Sylvester are: Interventional Radiology Also known as angiography, interventional radiology is an elegant means of studying the body’s many blood vessels, along with the organs that they supply. Radiologists position a narrow tube within the vessel, then inject a special compound that makes the vessel and its surrounding tissue visible on x-ray images. Stereotactic Breast Core Biopsy After a suspicious area of the breast is identified on a mammogram, a biopsy is often done to extract a sample of the abnormal tissue for analysis. The stereotactic unit takes two x-ray images of the abnormal area from different angles, and a computer then uses those images to determine the precise location in which to place the biopsy needle. Positron Emission Tomography (PET) PET detects metabolic changes in the body’s tissues that may indicate the presence of malignant tumors. PET is especially useful in the detection of malignant, metastatic tumors, those that have spread from the primary site to other locations within the body. Multi-Slice Computerized Tomography R A D I A T I O N O N C O L O G Y: A T E C H N O L O G I C A L L E A D E R (MSCT) MSCT takes rapid, cross-sectional O ne of the most technologically advanced centers in the Southeast, the Department x-ray images that can be displayed of Radiation Oncology at UM/Sylvester offers an extensive variety of treatment tech- three-dimensionally with startling niques including Intensity Modulated Radiation Therapy (IMRT) as well as low- and high- clarity. MSCT enables radiologists dose rate and intravascular implants of radioactive material (brachytherapy). The to evaluate the arteries of the heart department also treats tumors of the eye, orbit, and eyelids and offers eyeplaque for the presence of calcium, a pos- brachytherapy (with Bascom Palmer Eye Institute) and is the only institution in South sible precursor of more serious Florida to offer total skin electron beam therapy for cutaneous lymphomas. heart disease. Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 17 IN THE NEWS B R A M A N F A M I LY BREAST CANCER INSTITUTE MAKES EXCELLENT PROGRESS IN FIRST YEAR S ince its inception last fall, the Braman Family Breast Cancer Institute at the University of Miami Sylvester Comprehensive Cancer Center—a new institute that combines basic science with clinical trials and world-class care to discover more effective treatments for breast cancer patients—has witnessed tremendous advances, thanks in part to an aggressive recruitment effort led by its director, Joyce Slingerland, M.D., Ph.D. Several new faculty members have already been recruited with many more on the way. Stefan Glück, M.D., Ph.D., will soon come on board as clinical associate director, coordinating clinical breast cancer services and clinical research. Other hires include new faculty experts in the areas of breast radiology, breast Joyce surgery, psychological Slingerland, support of breast cancer M.D., Ph.D. patients, and breast cancer genetics, to name just a few. “We have significantly expanded our therapeutic Clinical Trials Program for breast cancer patients, and now have 13 therapeutic clinical trials open and another eight new trials being developed for breast cancer patients. These are trials of new drugs and new surgical or radiation therapy techniques,” says Slingerland. Institute staff is now carrying out a clinical trial to test a new method of breast irradiation that provides a very 10 18 Q U EST localized radiation treatment to the breast. A number of molecular targeted therapies combined with anti-estrogen therapies are also currently in the works. The institute also has received funding from the State of Florida to expand its community outreach and patient education arm. The Braman Family Breast Cancer Institute together with the Institute for Women’s Health at the University of Miami will create this Breast Cancer Education Program that will have an important focus on the indigent population. The Breast Cancer Genetics facility is also expanding, thanks to added clinic space that was made available by Jackson Memorial Hospital. U M / S Y LV E S T E R AT DEERFIELD BEACH RECEIVES WARM WELCOME R esidents have embraced UM/ Sylvester at Deerfield Beach, the cancer center’s satellite facility in northeast Broward County, which officially opened last January. The warm reception is an indication of the growing community’s need for such cancer-related services. One of the reasons UM/Sylvester decided to expand northward was the fact that approximately 40 percent of its patients were travelling to Miami from Broward and Palm Beach counties. The 10,000-square-foot facility offers residents of both counties a broad range of cancer-related services, including physician office visits, education and outreach, complementary therapies from the Courtelis Center for Psychosocial Oncology, and access to clinical trials. Due to increasing demand from patients, UM/Sylvester at Deerfield Beach has added pain management to its lineup of services. Patients with acute, chronic, and cancer-related pain now can be evaluated and treated in both inpatient and outpatient settings. Diagnostic assessment and a range of invasive and non-invasive therapies also are available. Many education and outreach programs are offered at Deerfield Beach as well. Conversations About Cancer, a series of free classes and activities given by physicians and other health care professionals, provides residents information on a variety of topics including cancer prevention, treatment, stress relaxation, women’s wellness, and many more. Free health screenings and support groups are also offered here. Since the facility’s opening, more than 500 residents have benefited from its education and outreach activities. PAP CORPS GIFT BREAKS RECORD C elebration was in order last May when the Papanicolaou Corps for Cancer Research pledged a record-setting $10 million to support cancer research at UM/Sylvester. As the first major philanthropic announcement for the University of Miami and UM/Sylvester in Palm Beach County, the generous donation is the largest gift in the history of the Pap Corps and one that was well received. The Pap Corps was recently inducted into the University’s new Miami Society. The ongoing support of the Papanicolaou Corps, whose headquarters are now located at UM/Sylvester at Deerfield Beach, funds critical research at the cancer center, including work in tumor immunology, cancer cell biology, and genetics. It also has assisted investigations of melanoma, ovarian cancer, and new diagnostic tools for a variety of cancers at UM/Sylvester. TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER MAKING A DIFFERENCE MESSAGE FROM THE CHAIRMAN OF THE BOARD OF GOVERNORS U M / S Y LV E S T E R BOARD OF GOVERNORS Fiscal year 2003 Joaquin F. Blaya, Chair Diane Abrams William H. Allen, Jr. Minor Anderson Joe Arriola Cynthia L. Augustyn, J.D. Jose Bared Gloria Berkowitz Minette Brown Robert Burlington Ira C. Clark John G. Clarkson, M.D. Diane M. Cook Michael Elliott Denny Feinsilver Thomas J. Fitzpatrick Bernard J. Fogel, M.D. Gail Gidney W. Jarrard Goodwin, M.D., F.A.C.S. Rose Ellen Greene, Vice Chair Mark Halpern Peggy Hollander Sherrill W. Hudson Thomas B. Levinson, Vice Chair Alan J. Livingstone, M.D. Jayne S. Malfitano Frederick L. Moffat, Jr., M.D. Eugene K. Montoya Sharon Pontious, Ph.D., M.S.N. Joseph D. Rosenblatt, M.D. John Schulte Anne Smith, R.N. Richard Spring David L. Stansberry Barbara Weintraub Jay Weiss Joined the Board since the beginning of fiscal year 2004 Michael B. Fernandez George Mencio, Jr. Marvin O’Quinn, succeeded Ira C. Clark Dennis Patin, M.D., succeeded Frederick L. Moffat, Jr., M.D. Nilda P. Peragallo, Dr.P.H., R.N., F.A.A.N., succeeded Sharon Pontious, Ph.D., M.S.N. S ince joining the University of Miami Sylvester Comprehensive Cancer Center several years ago, I have been pleased to see how far the cancer center has come and how much we have been able to offer the community. But there is still so much to do. UM/Sylvester has a bold vision—to join the ranks of the best cancer centers in the world—and I am proud to be a part of that endeavor. Despite an encouraging decline in age-adjusted death rates over the last decade, cancer will soon replace cardiovascular disease as Joaquin F. Blaya the number one killer of Americans. Our population is older than that of other communities, and, we will have more health problems in the future. Cancer will surely be one of them. UM/Sylvester’s role becomes even more imperative: to diagnose and treat patients with cancer and, ultimately, find a cure. As South Florida’s only university-based cancer center, we are leaders in research, education, prevention, and delivery of the highest quality patient care. We are committed to providing state-of-the-art treatment and breakthrough research, and we owe it to our community to offer that level of service. UM/Sylvester will soon embark on a capital campaign that will raise the level of giving. As a board member, I cannot conduct breakthrough research nor can I treat patients; however, I can join my community in the fight against cancer. It is philanthropic, corporate, and community support that will help fund this community treasure going forward. No doubt, with your support, UM/ Sylvester is one of the premier cancer research and treatment facilities in the nation. Your generous efforts go a long way in reducing the human burden from cancer in this community, and together we will make a difference. Joaquin F. Blaya Chairman of the Board of Governors, UM/Sylvester Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 19 MAKING A DIFFERENCE S U P P O R T F O R U M / S Y LV E S T E R C O M E S IN ALL SHAPES, SIZES A cross town and across the nation, people from all walks of life are supporting the search for a cancer cure. Their support comes in the form of book sales and bake sales, grand balls and grand slams, and just about everything in between. Whatever the effort, wherever the stage, one thing remains the same—these folks are doing whatever they can to help fight a disease that has touched the lives of so many of their families and friends. While it would be impossible to chronicle all that has take taken place in the past year to support the important work at UM/Sylvester, we’ve chosen to highlight a few. They are just a small sampling of the myriad ways so many people are making a difference at the University of Miami Sylvester CompreTHANK YOU TO THE S TAT E O F F L O R I D A O hensive Cancer Center. n behalf of our many physicians and scientists—and our patients, the direct beneficiaries of our translational research efforts—UM/Sylvester GALA NETS RECORDBREAKING $1 MILLION FOR CANCER RESEARCH wants to thank the legislators and residents of the State of Florida for their support during a very challenging budget year. The allocation of state funds to the University of Miami Sylvester Comprehensive Cancer Center has enabled us to continue our very important work in the development of cancer vaccines, biological therapies, and other breakthrough treatments. Furthermore, the allocation for breast cancer research has allowed us to significantly enhance our current research initiatives in fighting this disease. Again, we appreciate your support and pledge to work each day to earn it. 10 20 Q U EST W ith the generous support and enthusiastic commitment of more than 600 South Florida philanthropists, celebrities, and friends, UM/ Sylvester’s biennial “In the Garden” gala raised more than $1 million to benefit cancer research. It was a record-breaking night for the cancer center, and one of the most celebrated events of the South Florida social season. Hosted by Gala Grand Honorary Chairs Fran and Mel Harris, Gala Honorary Chair Cynthia Davis Carr, and Celebrity Chair Tara Gilani, the November 2002 spectacular at the Fontainebleau Hilton Resort marked the cancer center’s ten-year anniversary. Among the evening’s highlights were the announcement of six new Founder level commitments and the presentation of the prestigious Caroline W. Halpern Award to Jay and Renee Weiss. The gala’s silent auction featured luxury merchandise donated by world-renowned retailers, resorts, restaurants, hotels, cruise lines, and jewelers. Of the evening’s memorable moments, none stood out more than the realization of the tremendous impact one group of dedicated individuals can have when it comes to making a difference in the battle against cancer. TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER MAKING A DIFFERENCE ACE! E ver since professional tennis coach Dean Goldfine lost his mother to breast cancer in 1998, he’s been dedicated to raising funds to fight the deadly disease. In just three years he’s raised more than $300,000, of which he’s donated $200,000 to UM/Sylvester. From left to right: Amy Martin with son Jackson, Todd Martin, Dean Goldfine, Jessica Goldfine, Dr. W. Jarrard Goodwin at the Third Annual Pat Goldfine Tennis Pro Tournament. The annual Pat Goldfine Tennis Tournament, now in its third year, pairs up amateur tennis players with professional male and female tennis players for a competitively formatted pro-am. Andy Roddick, Jim Courier, and Mary Joe Fernandez are just a few of the tennis greats who have participated in the event. Each year it is followed by a private dinner and live auction for all participants and sponsors. For two years now, UM/Sylvester has been the exclusive beneficiary of the event. This year’s tournament took place at the Westin Diplomat Resort and Spa in Hollywood. Goldfine, who currently coaches Todd Martin, is recognized as one of the most successful professional coaches in tennis. He’s also coached Aaron Krickstein and Mary Joe Fernandez. His fundraising endeavor, a spin on the sport, is quickly gaining awareness as a smashing success for cancer research. J AY A N D R E N E E W E I S S : 2002 CAROLINE W. HALPERN AWARD RECIPIENTS I t was Bernard Fogel, M.D., dean emeritus of the University of Miami School of Medicine, who urged Renee and Jay Weiss to become involved with the University of Miami Sylvester Comprehensive Cancer Center more than a decade ago. His request was one that would be met with unimaginable generosity and selfless dedication. Renee and Jay Weiss’ passion for the cause, and their tireless commitment to helping eradicate cancer and advancing both research and treatment at UM/Sylvester, made them the natural choice for the 2002 Caroline W. Halpern Award. W. Jarrard Goodwin, M.D., F.A.C.S., director of UM/Sylvester, bestowed the highly coveted award upon the Bal Harbour couple last November at UM/ Sylvester’s biennial “In the Garden” gala. W O L D E N B E R G F O U N D AT I O N G I F T H O N O R S C A R O L I N E H A L P E R N C aroline Halpern was a dedicated supporter of the University of person,” says Brown. When her mother was di- Miami Sylvester Comprehensive Cancer Center long before she agnosed, Brown remembers her words as they became a patient. In fact, she supported the cancer center financially walked through the cancer center’s lobby, “She for years before beginning her own four-year battle with lung cancer. said, ‘I was on the ground floor of all this, but I As an administrator of the Woldenberg Foundation, a New Orleans- never dreamed I would be a patient.’” based foundation established by her uncle, Malcolm Woldenberg, Halpern was introduced to the cancer cen- Halpern helped direct an annual donation to the cancer center. After ter by long-time family friend Jay Weiss. Brown her death just six years ago, her children have carried on the support says once he told her the story of the facility—then called the Papanico- in the form of a donation in their mother’s honor. To date, that support laou Cancer Research Institute—and brought her in, she was hooked. has amounted to more than $1 million. Minette Brown Halpern’s support of the cancer center was so meaningful, the “My mother was so committed to UM/Sylvester,” says Minette hospital established an award in her name, the Caroline W. Halpern Brown, Halpern’s daughter who lives in Plantation, Florida, and sits on Award. She was the first recipient of the annual award, followed by Bar- the foundation board with her brother, Mark Halpern, of Surfside. “We bara Weintraub in 1994, Cy and Helene Somerstein in 1996, the do everything we can to perpetuate the gift.” Brown and her brother Grossman Family in 1998, and Jay and Renee Weiss in 2002. also sit on UM/Sylvester’s Board of Governors. “She was a major supporter, yet a very private and very humble Q U EST “She really cared about UM/Sylvester,” says Brown. “She really made a difference.” TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 21 MAKING A DIFFERENCE Established in 1994, in honor and recognition of Caroline Halpern’s commitment to supporting cancer research, the award recognized the true sense of giving back to the community. Giving Jay and Renee Weiss with University President Donna E. Shalala back is what Renee and Jay Weiss seem to do best. “Jay has been a phenomenal driving force behind the cancer center; he has been an unparalleled spokesman on our behalf,” says Goodwin. “His vision and leadership have invigorated and inspired us to reach new heights.” Jay Weiss, a founding executive with Southern Wine and Spirits, has generously given his time and financial support to the University of Miami, and particularly UM/Sylvester. He served as chairman of the Board of Governors of UM/Sylvester for eight years, and is a past chairman of the Miami-Dade County Public Health Trust, which oversees Jackson Memorial Hospital. He currently serves on the University of Miami’s Board of Trustees and his wife is a Grand Founder of UM/ Sylvester. The Weiss family firmly believes in UM/Sylvester and understands Gloria Berkowitz 10 22 Q U EST the vital need for a world-class cancer treatment and research facility here in South Florida. Their efforts are focused on helping improve early detection and better treatment today, while achieving their dream of one day eliminating death from cancer. They recognize the absolutely critical role that funding plays in realizing their goals. The spirit of philanthropy runs deep in the Weiss family. Renee and Jay’s four daughters also are actively involved in a number of charitable and community activities. They are determined to carry on the family tradition of giving back and setting an example for their own children. “To say they are charitable is an understatement,” says Fogel. “They care so much about people, especially those who are not as fortunate as others. Anything they can do to help, they do.” GLORIA BERKOWITZ, PRESIDENT OF THE PAPANICOLAOU CORPS G loria Berkowitz, president of the Papanicolaou Corps for Cancer Research, has a vision. Her hope is that one day the organization she represents will cease to exist because a cure for cancer will have been found. It’s certainly not unthinkable, especially after the Pap Corps donated $2 million and pledged a record-setting $10 million over the next five years for research efforts at the University of Miami Sylvester Comprehensive Cancer Center last May. “Cancer is something that affects every- body, whether directly or indirectly— it affects you no matter what,” says Berkowitz, president of the Pap Corps, a volunteer group with 13,000 members across four counties that has supported cancer research at the University for 51 years. “A lot of our members are survivors,” adds Berkowitz. “Our members truly believe, and I believe, that the cure will only come from research.” “Research cures cancer, and no group works harder than the Pap Corps to support that effort,” says W. Jarrard Goodwin, M.D., F.A.C.S., director of UM/Sylvester. The ongoing support of the Papanicolaou Corps funds critical research at UM/Sylvester, including work in tumor immunology, cancer cell biology, and genetics. It has also assisted investigations of melanoma, ovarian cancer, and new diagnostic tools for a variety of cancers at South Florida’s only university-based cancer center. “Whether it’s members sitting with the Cans for a Cure in front of Publix or running a golf and tennis tournament that makes $150,000, it all comes together,” Berkowitz adds. “There would be no Corps without the members, and they each have their own way to get to the goal—funding cancer research.” DENNY AND PAUL F E I N S I LV E R W hen Denny Feinsilver puts her arms around something, her heart tends to follow. That’s when the act of getting involved explosively shifts from generous support to full-fledged activism. “If there was anything in the world we wanted to be involved in, it was TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER MAKING A DIFFERENCE cancer research,” says Denny. “Research is the only thing that will cure cancer. By getting involved, we’re protecting our future—our families, our colleagues, our friends, and our community.” Her husband, Paul, is behind her every step of the way. In just four years, the Feinsilvers have rooted themselves in the cancer center, becoming founding members of Friends for SylDenny and Paul Feinsilver vester. Together, they sit on the boards of Friends for Sylvester and the Founders’ Society, which Denny now co-chairs. Ironically, on the day they were named to the Founders’ Society, cancer touched their lives in a personal way. The experience solidified their belief that UM/Sylvester is one of the top cancer centers in the world, and today, the Feinsilvers are Grand Founders. When it came time to celebrate the successful outcome of their personal experience with cancer, Denny launched Coupons for a Cure. The successful fundraising program she developed turns the thoughtful deed of gift giving into a meaningful opportunity to support cancer research. In its first full year, the program generated 132 coupons (or donations to the cancer center). Just two years later, the number rose to 1,300, a figure Denny predicts will exceed 2,000 this year. “It’s a simple, user-friendly program,” she says, “that is not only selfperpetuating in its growth, but also is enhanced by additional programs dur- Q U EST ing the holidays as well as displays at local businesses.” In 2001, Denny chaired the inaugural Live on Lincoln, a major biennial Friends event that raises funds for cancer research through a celebrity performance, an exclusive pre-theater dinner, and a spectacular live auction. This year’s event (November 13), which Denny will chair again, features renowned actor Tony Danza, and is expected to raise more than $250,000 for cancer research. “This is an institution we believe in,” says Denny. “We’re committed to more than just financial support. We’re committed to getting the word out and marketing the cause. We want to let people know how very fortunate they are to have UM/Sylvester in their own backyard.” THE BERNICE KRASLOW OVARIAN CANCER RESEARCH FUND W hen UM/Sylvester physicians diagnosed Bernice Kraslow with third-stage ovarian cancer in 1990, both she and her husband, University of Miami Life Trustee and Public Health Trust Board Member David Kraslow, were shocked. “They call this the silent disease of women because it usually produces few symptoms,” says Hervy E. Averette, M.D., American Cancer Society professor of oncology, Division of Gynecologic Oncology at UM/Sylvester. Then, of course, came the questions. What were her treatment options? What were her chances for recovery? What next? “The initial diagnosis was that she would live another two to three years. She might live longer or less. There was no guarantee,” recalls David Kraslow. “Fortunately, she was a fighter. She received superb care at UM/Sylvester, and she lived another 12 years.” Standard therapy for advanced ovarian cancer involves surgery, followed by chemotherapy. According to Averette, Bernice’s doctor, extensive surgery was performed to remove the bulk of the tumor. In addition to follow-up surgeries, she was placed on a dozen different types of regimens of chemotherapy and drugs over the next 12 years. Bernice responded well to the treatment most of the time. “The uniqueness of this case was that Bernice Kraslow was tough; she was a fighter and as feisty as anyone I have ever seen,” recalls Averette. “Bernice hung in there—I don’t think that I ever made a suggestion that she didn’t follow.” During her 12-year bout with the disease, Bernice didn’t sit idly by. Determined to help other women in the same situation, she created a forum at UM/Sylvester to allow cancer patients to support each other through knowledge and hope. She also fielded calls from women from around the country who called her to share their experiences, often finding inspiration in Bernice’s remarkable story of sur- David Kraslow vival. Her efforts even caught the eye of cancer center staff, who presented Bernice with a business card that read: Bernice Kraslow, Cancer Educational Consultant. “Bernice asked a lot of questions after the first surgery and started researching the disease and talking to people,” recalls Kraslow. “That’s when TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 23 MAKING A DIFFERENCE she decided that she would be a source of knowledge for other women with ovarian cancer.” Bernice had a severe setback in July 2001, and she agreed the time probably had come to engage hospice. But she rallied remarkably, tore up the hospice papers, and survived another year with a reasonably good quality of life. She died in July 2002. “She was a survivor,” says Averette. “She had the perfect positive attitude to do what she had to do to be with her family until the very end.” In memory of Bernice and her tireless efforts to help others, the family created a fund in her name for contributions to cancer research—the Bernice Kraslow Ovarian Cancer Research Fund. “Both Bernice and I were determined to create a program to support research at UM/ Sylvester,” says Kraslow, “and at the time of her death, I was convinced that this was the thing R. Kirk Landon to do. This fund is in concert with everything that she had done during the course of her illness.” Kraslow, in fact, believes wholeheartedly that more individuals should support cancer research. This notion has even trickled down to other members of his family. For his Bar Mitzvah project, grandson Ryan Dandes solicited collectibles from the Hurricanes and other sports teams, which he raffled off to raise money for his grandmother’s fund. The effort raised more than $600. “Not only did we create the fund as a way to memorialize Bernice, it was a way of creating a vehicle to support 10 24 Q U EST research dedicated only to ovarian cancer,” says Kraslow. “It’s not a closed fund by any means; we welcome any penny that comes in.” R. KIRK LANDON R. Kirk Landon truly believes in cancer research and feels strongly that South Florida deserves a worldclass cancer research center. So strongly, in fact, that he’s put the financial support of his family’s foundation behind the facility he says is among the best in the Southeastern United States. Landon understands that research is what ultimately will find a cure for cancer. And, he knows that financial support is key to advancing that research. Thus, when charged with the responsibility of administering the Kirk A. and Dorothy P. Landon Foundation, Landon approached UM/Sylvester about establishing a prize program for cancer research. The foundation was established by a bequest from his stepmother who willed that her estate be committed to medical research, especially cancer research. That meeting, and several that followed, became the foundation for the Landon-AACR Prizes for Cancer Research, two of the world’s most lucrative prizes for cancer research. Early next year, UM/Sylvester, along with the Landon Foundation, will host the second annual ceremony awarding two, $200,000 prizes for cancer research. The first will be given to Charles J. Sherr, M.D., Ph.D., from the Howard Hughes Medical Institute, who will receive recognition for basic cancer research in the area of tumor cell biology. The second, for his work in translational cancer research, will be given to Dennis J. Slamon, M.D., Ph.D., from the Jonsson Comprehensive Cancer Center at UCLA. The 2004 event will take place January 16. As part of the program, and because of Landon’s deep regard for the important work under way at UM/Sylvester, the award recipients spend time in Miami exchanging ideas with UM/Sylvester faculty. Landon realizes it is UM/ Sylvester that is truly advancing cancer research in the region, something he believes is absolutely vital to the well being of the community, which he adores. “UM/Sylvester has recruited some of the country’s most outstanding cancer researchers,” he says. “As they continue to add to that program, they will continue to do more and more in the fight against cancer.” Landon says giving “constantly and continually” to cancer and cancer research is essential. “The more we can do, the better we can be,” he says. “When it comes to cancer, it’s not a question of if, it’s a question of when. The numbers are staggering; everyone has had some kind of cancer experience, somewhere in their family.” Landon praises the recent strides made at UM/Sylvester to advance basic and translational research. JOHN AND JUDY S C H U LT E I t takes a few tries to get John Schulte to agree to talk about the contributions that he and his wife, Judy, have made to the University of Miami Sylvester Comprehensive Cancer Center. He shies away from the spotlight, TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER MAKING A DIFFERENCE uncomfortable discussing the business acumen that has allowed him to be a donor today. Ignoring the Schultes’ story, though, would mean missing the chance to bring attention to this couple’s strong belief that people need to get involved and stay involved. “John is extremely private about his involvement,” says Joaquin Blaya, chairman of UM/Sylvester’s Board of Governors. “But his commitment is unbelievable. His actions are a stronger statement than anything that could be said verbally.” Since becoming members of the Founders’ Society five years ago and more recently the Ashe Society, John and Judy Schulte have become an impressive force in the fight against cancer. Each year, the Schultes contribute to cancer research in the hope that others will benefit from their gifts. Their goal is to renew their Founders’ Society membership each and every year. When John was named to the Board of Governors last year, he renewed his commitment to help improve every facet of cancer care at UM/Sylvester. “We consider ourselves to be very ordinary people who live very private lives,” John says. “Along the way, we have been blessed to be able to make extraordinary contributions to such an important cause.” Judy and John Schulte Q U EST T H E S P R I N G F A M I LY I life. Today Jeanne is cancer-free, enjoying her family and new grandchild. “No question, the best line of attack is going to a major medical center,” says Richard. “For those living in Florida, UM/Sylvester is the place to go to get the best, state-of-the-art treat- n 1989, Jeanne Spring was diagnosed with squamous cell cancer. Following surgery, chemotherapy, and radiation therapy, multiple complications developed. During the next four years, the Spring family spent endless hours waiting to see the best doctors New York had to offer. “When a person is informed they have cancer, after the initial shock, they think in terms of finding the best medical care possible. Many think of going North to a well-known hospital,” says husband Richard. “Our personal experiences show Left to right: Jennifer Spring, Jill and Adam Spring, Jeanne and Richard Spring, this may not be the Jean Marc de Silva, and Daniel Spring. best. The renowned hospitals are often overcrowded and ap- ment, as well as providing your loved pointments are difficult to get.” one with the best chance for recovery.” In 1994, Jeanne and Richard moved In gratitude, the Spring family has to Boca Raton. At that time, Jeanne’s donated to UM/Sylvester substantially condition worsened, requiring exten- in both money and effort. Richard sits sive surgery. She was cared for by a on the Board of Governors, the Sciennumber of doctors and hospitals in tific Steering Committee, and chairs Boca Raton and Fort Lauderdale— the Cancer Research Committee. Chileach prescribing different medications dren Daniel and Jennifer are involved and treatments—but her health with Friends for Sylvester. Richard and steadily deteriorated. At that point, ev- Jeanne were inducted into the Ibis Soeryone had just about given up hope. ciety last year, and this year Daniel and At the suggestion of a friend, the Jennifer became Grand Founders. Son Springs scheduled an appointment Adam and wife Jill are Founders and with a team of physicians at UM/Syl- soon will become Grand Founders. vester. These doctors performed addiTo date, the Spring family has dotional surgery, and oversaw her treat- nated more than $500,000 to fund ments and medications. UM/Sylvester’s cancer research effort, The coordinated team approach all with the hope of helping others, just worked. This team of doctors saved her as they were helped. TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10 25 MAKING A DIFFERENCE STRENGTH IN NUMBERS This listing is representative of gifts received during June 1, 2002 – May 31, 2003. B elow is a listing of the generous men and women, foundations and corporations, who link the South Florida community with its only university-based, research-oriented comprehensive cancer program. Together, we are reducing the burden of cancer for patients and their families in South Florida. $2,000,000 $15,000 - $24,999 Papanicolaou Corps for Cancer Research, Inc. (Merrick) Robert A. & Gertrude Barnett Foundation Louis Ducoff First National in Palm Beach Greater Miami Jewish Federation Herbert and Susen Grossman (Ibis) Joan Levy Cancer Foundation Thomas B. and Sandy Levinson (Founder) Lillian Lowen Mellon United National Bank Florence Mufson (Founder) The Stephen Muss Foundation, Inc. (Founder) Bill and Irene Panoff/PPI Group Gerald and Joan Robins (Grand Founder) Richard H. Simons Charitable Trust (Grand Founder) Harcourt M. & Virginia W. Sylvester Foundation, Inc. (Merrick) Women’s Cancer Association of UM (Merrick) Women’s Cancer League of Miami Beach & Greater Miami, Inc. (Ashe) $1,000,000 Norman and Irma Braman Family Foundation (Merrick) $100,000 - $249,000 The Applebaum Foundation Dorothy Besserman (Grand Founder) Estate of Sherlock Hibbs William G. and Alice Pannill (Grand Founder) Ronald A. Silver Charitable Foundation, Inc. John K. and Judy Schulte (Ashe) Richard and Jeanne Spring (Ibis) Woldenberg Foundation $50,000 - $99,999 Harvey R. and Roberta Chaplin (Grand Founder) Colson Hicks & Eidson Dade Community Foundation Steven Dwoskin (Founder) Jewish Communal Fund Mel and Fran Harris Foundation (Grand Founder) Sherman Simon (Grand Founder) United Way of Miami-Dade $25,000 - $49,999 ASCPA (American Society of Composers, Authors and Publishers) Joaquin F. and Isabel Blaya (Grand Founder) John and Barbara A. Cirino (Founder) David and Isabel Etter (Founder) Fontainebleau Hilton Hotel & Resort Estate of Will Hudson John McGuire* Stuart Miller Morgan Stanley Northern Trust Bank of Florida N.A. (Founder) Mario C. Rodriguez (Founder) University Shopping Center Bruce Weber 10 26 $10,000 - $14,999 John and Susan Adams (Founder) Anilam Acu-Rite Ansin Foundation Jerry and Nancy Blair The Cejas Family Foundation, Inc. (Founder) Chartwell Charitable Foundation Zita Danoff (Founder) * Eagle National Holding Company Farnsworth Farms Paul and Denny Feinsilver (Grand Founder) Terry & Linda Fenner First Miami Securities, Inc. N.M. B. Joel and Paula Friedland (Founder) Gerald and Rose Ellen Greene (Founder) Allen and Jill Greenwald Halogenetics, Inc. Thomas and Sherry Ireland James and Diane Klotz (Founder) David Kraslow Christopher and Jayne Malfitano Alvin I. and Nancy Malnik (Founder) Oceanview Club Development Co. LLC Pfizer, Inc. Corporate Affairs PharMed Group Corp. Podhurst Family Foundation, Inc. (Founder) Steven Posner (Founder) Q U EST Mark S. and Susan Rodack (Founder) Sands Brothers Rowland and Sylvia Schaefer J. David and Joan Scheiner (Founder) Lois H. Siegel The David & Susan Strauss Foundation, Inc. (Grand FFS) Phillip and Eileen Youtie (Founder) The Yulman Foundation (Founder) United Automobile Insurance CO. (FFS) Vanneck Bailey Foundation (Founder) Jay Weiss Family Foundation Inc. (Merrick) $5,000 - $9,999 Michael and Judy Adler Amadeus North America, Inc. Ray and Nancy Anderson Garner Anthony Cara and Bobby Balogh Family Foundation (Founder) Fred and Marilyn Berens (Founder) Terry L. Cardwell (Grand FFS) Codina Group, Inc. Commercial Bank of Florida Wileen Coyne Daughters Of Penelope Grand Lodge Sonja Eiteljorg (Founder) Samuel and Freda Epstein (FFS) Estate of Will Hudson Federated Stores Ginger Spirits, Inc. W. Jarrard & Sharon Goodwin, Jr. (Grand Founder) Jesse Gottlieb Mary M. Graham Green Family Foundation (FFS) Louis and Evelyn Grossman (Founder) Peggy Hollander (Ibis) Benjamin and Rita Holloway (FFS) H. I. G. Capital Management, Inc. Ingrid Hunter Jacksonville Greyhound Racing Bruce and Deborah Kaye Donald and Eileen Kramer Bowen A. Arnold and Trude Koby (FFS) Ella Kugelmann Edward & Bloosom Leibowitz Family Foundation, Inc. Ronald Levy Estate of Frank J. Lewis Thomas and Sandy Levinson (Founder) Charles J. Lopiccolo Ruben and Denise Lujo Merrill Lynch Trust Eugene K. and Jimmie Montoya (Founder) Ocean Bank Oren Development Corp. Terrence M. O’Grady (FFS) Rafael and Alexandra Ordonez Bruce Ovitz Alan Richardsen The Rubach Family Foundation (Founder) Pete and Susan Sibley Norman Shulevitz Foundation Lewis and Eileen Silberman Robert D. and Sheila Slewett (Founder) William D. and Jean Soman (Founder) Southern Wine & Spirits of America, Inc. Daniel Spring (Founder) Jennifer Spring (Founder) Standard Broadcasting Corporation Ltd. Sylvester Socialites Ilene F. Tessler C. Thomas and Donna Tew Tropic Supply, Inc. Ruth Wagner (Founder) Geoffrey S. Weisbaum Sherwood M. and Judith Weiser (FFS) William J. Whelan Young Family Foundation (Founder) Y.S. Liedman & Associates $2,500 - $4,999 Michael and Diane Abrams (FFS) AHEPA National Housing Corp. Ruby M. Bacardi Gail and Antoniette Baldwin (FFS) Bank of America Joel and Susan Barnett Donald and Geraldine Bohning Burdines, Inc. Charitable Gift Fund Andy M. Custer Downrite Engineering Corp. David and Beth Ertel (FFS) Scott Feder Jack and Mindy Finkelman Abbey Glassman Michael A. Gott Herschel and Nancy Green Maurice and Sonya Greenfield Jon Greenwell Jerome J. and Honora Grossbardt Hanzman Criden Chaykin & Rolnick, P.A. Florence Hecht Eugene J. and Elsie Howard (Founder) *deceased TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER MAKING A DIFFERENCE Elmer A. and Roslyn Hurwitz (Founder) Jacobson Properties Craig M. and Martha Johnson Michael D. and Susan Jones Brian King William and Carole Landa Hal and Rita Leeds Mark and Suzanne Levitats (Founder) Alan R. and Diane Lieberman The Mailman Foundation, Inc. Marion A. Roletti Foundation Inc. Mark J. Gordon Foundation Miles A. and Patty McGrane III Rolf Meijer-Werner Peter and Marion Mosheim Jeff and Selma Newman (Founder) Pershing Industries, Inc. The Potamkin Foundation (Founder) Benton and Ronnie Pumpian Harvey and Theodora Robbins (FFS) Harry and Ronni Shier (Founder) Michael A. and Peggy Silver Peter B. Simel Glenn H. Singer Family Foundation, Inc. Standard Pacific Corp. Technion Communications Corp. Thomsen Foundation, Inc. Grant Thornton Vintage Homes Of Parkland, Inc. Irving and Kay Waltman Alan and Patty Weinstein (FFS) WFOR-TV Williams Island, The Florida Riviera $1,000 - $2,499 Africk Family Foundation Inc. Samuel I. Adler Family Supporting Foundation Jonathan and Bonnie Aibel (FFS) Akerman Senterfitt Jon and Shirley Alexiou (FFS) Allstate Giving Campaign Ritchie and Barbara Ambers American Italian Association American Research Kemicals Peter Andolina Anonymous Barbara Cox Anthony Foundation Aventura Orthopedicare Center Cara Balogh (Founder) Bank One Corporation Bank United Alberto and Alegre Barrocas George L. and Ellen Baum Gary and Patricia A. Becker (FFS) BET Miami Greyhound Partnership Tito and Monica Betancourt Bernie Bercuson Steven Bernstein Donald and Suzanne Bezahler Andrew Blum Bonnie & Ilene Inc. Mark and Carol Brooks (FFS) Artie and Susan Brown Bruce and Jacquelyn Brown (FFS) Brown Jordan International, Inc. Robert and Alden Burlington (FFS) Calamos Asset Management, Inc. Camner Family Charitable Foundation Campaign to Re-elect Judge Ronald M. Friedman Edward J. and Susan Capuano Q U EST Carl’s Furniture, Inc. (Founder) Cesar E. and Claire Ceballos (FFS) Joe Chang Jerome and Jacqueline Chaves Geraldine V. Chavez Louis J. and Rosemarie Ciccotto Cobb Family Foundation City First Mortgage Corp. (FFS) Kendall and Joni Coffey Arthur and Diane Cohen (FFS) Rita & Jerome J. Cohen Foundation, Inc. Michael A. Comras and Susan Hally (FFS) Robert and Fredi Consolo (Founder) Credit Suisse First Boston Corporation Michael and Michele Criden (FFS) Glenn and Michelle Cutler (FFS) Steve and Arlyn Cypen (Founder) Dauer Family Foundation James W. Davidson Alicia M. Dahling (FFS) Dean and Kayrn Dekker (FFS) Leslie Delman Drehl & Larison, P.A. Dianne Dimond Warren and Carolyn Dodd Leonard and Adele Dublin (FFS) William G. and Cassandra Earle (FFS) Alex and Mary Claire Espenkotter (FFS) Jeanne-Marie Fascell Richard and Colleen Fain (FFS) Miguel and Nelly Farra (FFS) George Sparrer and LaReine R. Fedor (FFS) Michael and Clara Felsher Sanford Fenster Jose M. and Lilia Fernandez Fiber Seal of N.Y. Ted and Jeanette Fine Elaine Fink Iris Fisher Flagship Resort Development Company (Founder) Robert and Nancy S. Frehling (Founder) Albert and Muriel Freund John and Bonnie Gaebe Harold and Jill Gaffin (FFS) Richard and Barbara Garrett (FFS) B. Milfred Gerson Barry and Linda Gibb Jeff and Gail Gidney (Founder) Justin J. Gimelstob Glassman Development (FFS) Maynard Goldberg Frank Gomez Maida Gordon Greenhill & Co., L.C Grossman & Roth, P.A. Steven and Wendy Gurowitz (Founder) Susan Gutman (FFS) Mark M. and Margaret Halpern Michael A. and Reva Hanzman (FFS) Jeannette G. Harris (Founder) Tim Henman Paul and Susan Herman (FFS) Samuel and Barbara Herzberg Jeffrey Herzfeld Thomas and Kathy Hewitt (FFS) Mark and JoAnn Hildebrandt (FFS) Walter and Barbara Hinterkopf (FFS) David Stone and Sheri Hirschfield Hite Foundation Martin and Geraldine Hoffman Robert and Christy Hoffman Daniel M. and Toni Holtz (FFS) Laurie Holtz Robert and Virginia Horner* Scot L. and Barbara Hunter Garry J. Hurewitz IDS Telcom Richard and Marilyn Jacobs Craig M. and Martha Johnson K. Phillips & Co. Inc. Marc and Lori Kahn (FFS) Martin Kalb (FFS) Frank and Missy Kardonski (FFS) Jack and Arden Karson (FFS) Katcher Family Foundation, Inc. Katz, Kutter, Alderman, Bryant & Yon Charles D. Kelman Eugene and Lois Kessler (FFS) Herman H. Klorman Alan Kluger and Amy Dean (Founder) Robert and Gloria Kolikof Michelle R. Krinzman Richard C. Kronrad Richard J. and Susan Lampen (FFS) Larise Realty Group, Inc. Alan and Alice Lash (FFS) Everett and Lynne Lassman Albert & Temmy Latner Family Foundation Michael and Alexa Lazarus Stephen and Terri Lazarus (FFS) Leesfield Family Charitable Foundation Inc. David and Bette Lehman Lehman Dealership Enterprises, Inc. (FFS) Allen and Kathy Levi Meron and Carol Levitats (FFS) Sidney and Sandra Levy Daniel and Jan Lewis (Founder) James G. and Phyllis Lippman Lloyd/Flanders Industries, Inc. Carlos and Amada Lopez-Aguiar Lucky Brand Dungarees of America, Inc. Heinz and Marianne Luedeking Leo George and Mary Ellen Lynch (FFS) H. Larry and Penny Mager (FFS) Frances Maichin Manulife Financial Masarek Family Foundation, Inc. John McCarthy McCrea Foundation Victor and Lisa Mendelson (FFS) Minto Foundation, Inc. Fernando and Lynn Elena Miranda (FFS) George J. Mitchell Ricky and Amy Mittelberg (FFS) Paul and Adrianne Mittentag David and Tracy Moret (FFS) Ewan C. Moffat Melvin and Elaine Morse (FFS) Mirtha Orue Muller (FFS) Neiman Marcus Craig and Deirdre Nash (FFS) Steven W. Neckman Northwestern Mutual Foundation Scott and Shari Notowitz (FFS) Yair and Frieda Oren (Founder) Pallant Spring & Grace Gonzalo Parodi (FFS) Mary Carr Patton Ray H. and Georgia Pearson Michael and Karen Pernick (FFS) Joel S. and Jean Perwin (FFS) Richard and Erin Pfenniger (FFS) Philips Medical Systems North America Co. TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER Lester N. and Mary Pokorne (FFS) Richard H. Pollak Bruce W. Polozker John and Laura Pomerantz Irwin and Linda Potash Premier Parking Management, Inc. (FFS) Premier Wine & Spirits Michael and Lisa Puder (FFS) Arthur Queler (FFS) Rick Quintner Peter Cassileth and Judith Ratzan (FFS) Lillian Redlich Nathan and Carolee Reiber Charles and Valerie Riback (FFS) Richmond Jewish Foundation Alan Richardson (FFS) Norman and Myrna Ricken (FFS) Victoria J. Rogers (FFS) Roepnack Corporation Saul J. Rosen Stanley M. and Susan Rosenblatt Robert and Jill Rosenhaus Rosenstiel Foundation Claire M. Rotella Mark and Tobi Rousso (FFS) Sam and Dorothy Rubin (FFS) Raquel Rydz Saks Fifth Avenue-Bal Harbour (Founder) Salomon Smith Barney, Inc. Guillermo and Irma Sanabria Sanford Fenster San Jose Mercury News Douglas J. Sanders (FFS) Scharlin Family Foundation (Founder) James J. Schlesselman David and Stephanie Schwartz (FFS) Joseph and Gail Serota (FFS) David and Liliy Serviansky Daniel and Rita Shapiro Hy and Sheila Shapiro Sherry Shariatmadar H. Allan Shore (Founder) Dorothy Sibley (FFS) Scott A. and Susan Silver (FFS) Joseph Esformes and Kathy Simkins Richard Simon Guy and Teresa Skellenger Alan M. Slewett (FFS) Nancy Smith Songwriters Guild of America South Beach Insurance Agency, Inc. George Feldenkreis and Maria Srebnick Sterling USA, Inc. Tibor and Hana Stern (FFS) Sweet Paper Sales Corp. James D. and Janie Tate (FFS) Tate Enterprises Technical Olympic, USA, Inc. Todd and Desiree Tennen Maurice W. and Betty Terkel (FFS) Peter and Paula Trematerra (FFS) Denis P. and Linda Trupkin Harry N. and Alina Turk (FFS) Rita Ullman Joseph Weintraub Family Foundation, Inc. (Grand Founders) Union Bank United Way of Broward County, Inc. US Bank Vanguard Charitable Endowment Program Manuel and Carmen Villamanan (FFS) *deceased 10 27 MAKING A DIFFERENCE Diane Walder Michael Walder Jeanette Wax (FFS) Joseph Weintraub Family Foundation, Inc. (Grand Founder) Eric and Shelley Weis (FFS) Joel and Sally Weiss (FFS) Michael Weisser Warren and Jill Weisser (FFS) Maria L. Wiebelt William Hutton Associates, Inc. (FFS) Kenneth J. Wolf Allan and Barbara Wolk W. P. Productions, Inc. Allan and Ray Ellen Yarkin (FFS) Richard and Janet Yulman (Founder) Z Management Services, Inc. Joseph Zappala Paul Zarcadoolas (Grand FFS) Robert Zuckerman (FFS) $500 -$999 Advertising Direct Marketing Consultants of America Inc. Ronald and Eleanor Ager Barbara T. Alexander Andrew Alpert Michael and Randi Applebaum (FFS) Bernard Shapiro Fund Inc. Thomas and Karen Bezold (FFS) Big Pine Key Lions Club Jason Binn Stephen and Jill Bloch Donald and Geraldine Bohning Ronald Book Richard L. Braunstein Michael and Corina Browarnik Scott and Jodi Brown (FFS) Robert J. and Evelyn Carbonell Centex Homes Beryl L. Cesarano William and Dolores Chambreau Robert and Azucena Cherry City Photo, Inc Edmond Gong and Dana L. Clay Comerica Bank Harold and Alice Commings Corina Enterprises, Inc. Cox Enterprises, Inc. Crispin Porter Bogusky Wayne and Nicole Cypen Brian Davidoff Jean and Tallie Davis Deloitte & Touche Destination Resort Management, Inc. John and Marianne Devine (FFS) Dimensional Plastics Corporation Ethel Blum Dublin Eagle Brands, Inc. Seymour and Marsha Edelman Aaron and Andrea Edelstein Barry Ehrenfeld Eli J. Ehrlich Carol A. Eisenberg Stewart Eisenberg Lisa Enfield Jose and Lilia Fernandez Richard Finkelstein Adrian Fogel Lori J. Fogel Lloyd and Dolores Foley Stephen E. and Nancy Frank (FFS) 10 28 Fri-Mar Activewear & Shoes, Inc. Allen and Susan Fuller Evelyn Gargano Michael Gates Gateway Investment Advisers Henry and Ilene Gayer (FFS) Martin and Gladys Gelb James A. Gillis Daniel and Nancy Ginsberg Allan M. and Patty Glaser Peter S. Gold Michael C. and Cathy Goldberg (FFS) Patricia Goldsmith Gloria Gottlieb Gene and Pauline Grabarnick Greek Orthodox Ladies Philoptochos Society of St. Catherine Victor and Maralyn Green David and Andrea Grossman (FFS) Sheldon B. Guren Merrick W Hellyar Alan Hodes Lynn Hover Juliano H. Ibarra Jerry and Barbara Isan (FFS) Michael and Laura Jones Albert and Arlene Kahn Edythe Kay Perry and Annamae Kaye Roy and Caryl Barrie Kaplan Steven R. and Nancy Kaplan Kaufman Foundation, Inc. James Kennedy Alfred and Jane Ketcham Kiwanis Club of Deerfield Beach Ronald M. and Carol Kovnot Donald and Eileen Kramer Brad Krassner Stanley J. Krieger Richard and Margaret Kronenberg Roni and Joanne Laskin (FFS) Michael and Alexa Lazarus Marvin H. and Isabel Leibowitz Lennar Corporate Center & The Patronis Group Mike and Phyllis Levin Stanton and Sandra Levin Laurence Levy Alvin F. and Helen Lindsay Michael A. and Andrea Love Josie Manno Jeffrey and Barbara Martin Mechanix Wear Renthal America Medical Faculty Association of the University of Miami Hillel and Judith Meyers Jerry Milgram David Miller Harold S. Miller Kevin Fitzmaurice and Renu Mody (FFS) Ronald Molko Anthony R. and Beth Morgenthau Kelli Morris N. A. Crane Winston F. and Ruby Nees Joseph Nesbitt Stuart G. and Sandy Newman (Founder) Jim and Heidi Nosich Harvey Oxenberg Oxford Services, Inc. Hermine Pallot Eugene and Althea I. Peck Q U EST PEICO Corali Pino Jason H. Port Profit Concepts Q. Grady Minor & Associates, P.A. Mary Belle Quesenberry Jack Carmel and Katika Quittner (Founder) Joel and Sandra Rattner Steven Rindley Morton J. and Jane Robinson Juan M. Rodriguez Joann Rosen Robert and Jill Rosenhaus Ruden McClosky Smith Schuster & Russell, P.A. Steven Sanders David and Marli Sandri David and Carrie Schulman Deborah K. Schwarzberg Peter H. and Miriam Segall Ginny Sembello Howard and Frances Shapiro Steven and Ellen Shapiro Jean Scheinman Jeffrey G. Schwarz Craig B. and Ellen Sherman (FFS) Michael and Barbara Sherman (Founder) G. Robert and Joni Sheetz (FFS) Michael S. Smith Carol Soffer F. Ronald and Alexandra Mastriana-Solal (FFS) Somerstein Land Co. Richard N. and Carol Songer South Florida Trane Robert and Arlene Spevak Adam and Jill Spring David Stone Robert and Michele Stone Pat Strawgate Norman Strell John and Blair Strickroot Mathew and Linda Swalling J. Kenneth and Sandy Tate Francisco Tejada Jim Teper John W. Thatcher The Cartledge Foundation Inc. The Comras Company of Florida, Inc. The Dadeland Capri Apartments The Efron Foundation, Inc The Gloria and Sidney Danziger Foundation, Inc. The Hasey Foundation Tom Thumb Food Stores, Inc. University of Miami Philip J. and Sandra Walsh L. Austin and Marta Weeks William Morse David S. Wilson Julieana Wilson Pauline Winick Larry F. Witte David and Shelley Wolfberg Allan and Barbara Wolk Teri Esther Wolofsky Louis and Lillian Yagoda Antoinette Zel Richard and Susan Zinn (FFS) Richard Zipes Matthew Zucker $250 - $499 AD Hoc Law Associates, Inc. Harvey B. Adelstein Alexander Lynn & Associates Barry R. and Franne Alter Beatrice Arnel Jose and Lourdes Arriola (Founder) ASL Enterprises, Inc. Robert and Jo Ann Bass Betty Bellman Pedro F. and Barbara Bermann Kenneth and Marla Bern Todd and Diana Berwick Karl and Carmen Bishopric Bluestein and Wayne, P.A. B. Pila Design Studio Robert W Baird & Co. Foundation, Inc. BRESTL, Inc Elmer L. Bunge Barbara Burnstine Juan and Elda Cabrera CAM Associates Heloisa Campos Capital Rental Agency, Inc. Angel Castro Causeway Lumber Company Honorable Paul and Trudy Cejas (Founder) Kenneth and Merryl Chaitman Maria E. Chance Afif and Mona Chanouha Katherine A. Chouinard Terri Clark Dan and Patricia Cohen Jay Cohen Leonard and Brandy Cohen Nicholas Condorousis Richard Conway Steven and Susan Dandes Betty Y. Dean Perry and Geraldine Delman Victor Demetrion Nancy Donner Dennis Doucette Neil Eisenberg Lawrence and Carole Epstein Mark and Paula Epstein F. Mary Fee Michael and Nancy Feldman Michael Fichtel John W. and Iris Fisher Audrey Frankel Joseph and Joan Frechette Ann Fried Kathy S. Friedman Joseph Furfaro Solomon and Esther Garazi Fredeswinda Garcia Raymond L. and Jacque Gellein Terry Glasser Deborah S. Gold Sharon Goldman Charles J Goodell Ben and Gladys Goulding John and Doris Greaner Randolph and Anne Green Greater Houston Community Foundation James Griffin Wayne A. Haltiwanger John R. Hart, Jr. William Craig Hayes, III *deceased TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER MAKING A DIFFERENCE Manuel and Nyria Herran Barry and Cynthia Hersh Arthur H. Hertz Lawrence C. and Jacqueline Hoff Hometown Lending Group Hubert and Carolyn Hine Morton Howard Sherrill and MaryAnn Hudson Lavette Hunter I J Feldman Foundation In Source, Inc. Interamerican Bank Investec, Ernst & Company Issa Homes, Inc. Gilbert Jacobs Michael Kahn Abbey Kaplan (FFS) Alice M. Kaye Jeffrey B. Kaye Seymour Keith Ken Brahms Agency, Inc. Michael and Kimberley Kraft Lester and Anna Kreider J & D Financial Corp. Joe’s Stone Crab Restaurant Everett A. Jones Nelson and Tillie Lancione Marshall and Joy Landy Sidney and Ruth Lapidus Levi, Cahlin & Co. Sidney Levin Steven Dan and Sandra Lewis Jerry and Elena Lindzon Robert Lopinto Bernard L. and Meryle Loring Donna S. Lundy Lee Mandell Joel and Elaine Margolies Thomas and Angela Marroccoli Joseph Maya Susan Miller Carleton and Ruth Mitchell Garen and Jan Minkler MK Real Estate Group INC Beatriz Montanez Klara P. Mora Stanley J. and H. Moss Daniel and Denise Movens Myra P. and Company, Inc. Mary V. Nash National Provisions, Inc. Lucas C Nordejee Francisco J. and Elizabeth Olazabal Lawrence E. Major and Suzanne Pallot (FFS) Ana Paredes Dennis J. Patin Ana M Peña Armando A. Perez Albert Hernandez and Aymee Perez Ora F. Phillips Pipe Vine, Inc. Anolan Ponce Juan and Carmen Prieto Peter and Barbara Pruitt Stanley K. Reiss Ana Maria Reyes Richard Cheroff Sales, Inc. RMW Debbie Robins Edward Robinson Alejandro and Elda Robles Frank L. Rosenblatt Howard H. and Elaine Roth Neal and Vicki Roth Sondra Fleck Rubin Gina Russ Jon A. and Jayne Sale Richard Schaeffer Audrey Schanfald Carol Schiller Melvin D. and Gladys Schiller Alejandro R. Scopelli Stanley and Harriet Seren Gary and Dana L. Shear (FFS) Gary and Tina Silverstein Charles and Sandra Simon Kay Sirianni Eileen Solimene Carmi M. Slomovitz Starwood Vacation Ownership SVO-Legal Dept. Michael and Joan Storch Cynthia Swol Tanenbaum Harber of Florida The Zurich U.S. Foundation Barbara Tifford Titles Unlimited Inc. Sandro M. Tomaselli Eden Torres Robert H. and Jacqueline Traurig Carrie Ola Trop Omar and Haydee Vazquez Irving and Kay Waltman Water Works of Boca, Inc. Douglas Weiser Phyllis Weiss White & Case Vincent J. Wing Zubi Advertising Services, Inc. DONOR RECOGNITION SOCIETIES MERRICK $1,000,000 and above ASHE $500,000-$999,999 IBIS $250,000-$499,000 GRAND FOUNDER $100,000-$249,999 FOUNDER $50,000-$99,999 GRAND FRIEND $25,000-$49,000 F R IEN D S F O R S Y LV ES TER (FFS) Pledge $10,000 over a maximum of 10 years (cumulative giving levels) CIRCLE OF PROMISE M embers of the Circle of Promise belong to a select and unique group of individuals, distinguished by their generosity and determination to eradicate cancer. The Circle of Promise: helping more people in South Florida survive cancer. Abascal, Maria E. Adelstein, Harvey B. Angelo, Jr., Henry Arnel, Beatrice Baker, Elaine M. Baros, Evans E. Bayer, Cathy Behar, Saby Berg, Estelle C. Birger, Arlyne Bolz, Charles S. Brown, Elizabeth Byrne, Wynn K. Candib, Murray A. Carbonell, Robert J. Carmona, Leticia I. Castillo, Maria Pessoa Pereira Chonoles, Jack R Chouinard, Katherine A. Christenson, Joyce L. Clarey, John R. Clingan, Thomas A. Cohen, Leonard Cohen, Myrna Q U EST Corrigan, Melita Creative Pharmacy Services, Inc. Cristy, Delia Crocker, John F. Dingeldein, Margarete Epstein, Paula Esman, Theresa M. Fennell, Trudy H. Filloramo, Ida Fink, Renee Frechette, Joan G. Galatz, Arthur Galperin, Martha Goldman Glasser, Meredith C. Gonzalez-Mir, Jaime J. Goulding, Gladys Greaner, Doris F. Green, Anne Wilson Green, Donald M. Hagelberg, Beatrice Herran, Manuel Hokin, Eugene F. Hyman, Michael L. Jackson, Myrtle M. Jordan, Betsy P. Kaiser, Gerard A. Kaplan, Edward S. Ketcham, Alfred Kingsberg, David M. Kramer, Donna R. Kranitz, Florence Leitner, Irving Levin, Sandra Levy, Marvin Lindsay, Alvin F. Longo, Marteen Lopez, Luis E. Lopez-Aguiar, Carlos Lopinto, Robert Loring, Bernard L. Lundy, Edith Milo, Anne M. Moffat, Ewan C. Mooers, Malcolm M. Moses, Edward A. Movens, Denise Muroff, Gloria Nelson, Audrey R. Nichols, Eleanor M. Nitenson, Sheldon Ober, Marjorie Y. P.A.L. Resources, Inc Parent Services, Inc. Peña, Ana M Purcell, Ania S. Rabin, George M. Rebhan, Lori Rechtman, Lorraine Retchkiman, Guillermo Robins, Idah D. Rodriguez, Eloisa Rodriguez, Juan M. Roggenburg, Sanford Rosen, Muriel Rosenblatt, Frank L. Ruiz, Angela G. Ruiz, Manuel Sandberg, Deborah D. Schleifer, Nancy Schwartz, Jay D. SECO Supplies, Inc TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER Sendlein, Lyle V.A. Shochet, Suzanne Shuminer, Leila K. Silverstein, Raquel Simon, Sandra Stavrojohn, Evonne S. Stein, Marcia G. Steinberg, Harris N. Stern, Donald E. Stock, Shara L. The David & Susan Strauss Foundation, Inc. Tate Enterprises Taylor, Charles G. Thornton, Melinda S. Vazquez, Haydee C. Vazquez, Rosa Wahl, Thomas B. Waldron, Edward J. Weinberg, Frances Weiss, Phyllis Wiegand, Joseph P. Yambo, Inc. Zarcadoolas, Paul 10 29 FACTS AND FIGURES U M / S Y LV E S T E R I S O N T H E M O V E A careful look at our financial and clinical profiles shows that UM/Sylvester is a financially strong and growing cancer center, and an important source of research funding throughout the University of Miami School of Medicine. FINANCIAL PROFILE—HOSPITAL FY 2001 FY 2002 FY 2003 SOURCES OF REVENUE (Figure 1) Net patient revenue Other revenue (operating and non-operating) $89,884,430 2,278,481 $108,002,717 2,986,515 $108,829,476 2,732,015 TOTAL REVENUE $92,162,911 $110,989,232 $111,561,491 USES OF REVENUE (Figure 2) Salaries and related costs $29,821,556 $32,620,669 $38,102,336 Supplies 16,606,237 19,229,674 20,850,783 Utilities and maintenance Purchased services 3,350,418 12,877,814 3,366,238 15,889,997 3,741,965 17,673,474 Provisions for bad debt TOTAL OPERATING EXPENSE 4,841,166 6,436,286 4,416,075 $67,497,191 $77,542,864 $84,784,633 $24,665,720 $33,446,368 $26,776,858 INCOME BEFORE FINANCING COSTS, DEPRECIATION, AND SUPPORT OF ACADEMIC MISSION Financing costs and depreciation Support of academic mission* $5,901,361 $6,903,344 $7,197,727 $18,764,389 $26,543,024 $19,529,131 *Each year the hospital contributes a portion of its net revenues to support the academic mission (research, teaching, and clinical care) of UM/Sylvester and the University of Miami School of Medicine. FINANCIAL PROFILE—RESEARCH FY 2001 FY 2002 FY 2003 SOURCES OF REVENUE (Figure 3) Institutional support Hospital $600,000 $1,125,313 $1,125,313 School of Medicine State of Florida 252,287 2,500,000 241,632 2,000,004 1,234,030 1,875,192 $3,352,287 $3,366,949 $4,234,535 $6,010,421 25,314,065 $5,536,540 28,345,095 $7,279,347 30,775,619 $34,676,773 $37,248,584 $42,289,501 $31,484,772 $34,765,859 $38,652,635 1,424,188 1,022,916 1,456,549 1,767,813 $34,676,773 1,459,809 $37,248,584 2,180,317 $42,289,501 Total Institutional Support Philanthropy* (Figure 5) Cancer-related sponsored program funding TOTAL REVENUE USE S OF RE SEARCH FUN DIN G (Fi g ure 4) Investigator/research programs Research resources Infrastructure TOTAL RESEARCH FUNDING *With the exception of sponsored program funding in the form of grants, UM/Sylvester relies most heavily on philanthropic support to fund cutting-edge basic and translational research. F I N A N C I A L P R O F I L E — U M / S Y LV E S T E R Total revenue—hospital Total revenue—research TOTAL REVENUE (Figure 6) 10 30 Q U EST FY 2001 FY 2002 FY 2003 $92,162,911 $110,989,232 $111,561,491 34,676,773 37,248,584 42,289,501 $126,839,684 $148,237,816 $153,850,992 TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER FACTS AND FIGURES S O U R C E S O F R E V E N U E — H O S P I TA L U S E S O F R E V E N U E — H O S P I TA L FIGURE 1 FY 2003 FIGURE 2 FY 2003 $2,732,015 17.5% 34.2% 6.5% 4% $108,829,476 15.8% 3.4% Salaries and related costs Supplies Utilities and maintenance Purchased services Net patient revenue Other revenue (operating and non-operating) SOURCES OF REVENUE— RESEARCH 18.7% Provisions for bad debt Financing costs and depreciation Support of academic mission USES OF REVENUE—RESEARCH FIGURE 3 FY 2003 FIGURE 4 $1,125,313 $1,234,030 $1,875,192 FY 2003 3.4% 5.2% $7,279,347 Hospital School of Medicine State of Florida Philanthropy Cancer-related sponsored program funding 91.4% $30,775,619 Research resources Infrastructure Investigator/research programs PHILANTHROPY T O TA L R E V E N U E —U M / S Y LV E S T E R FIGURE 5 FY 2001-2003 FIGURE 6 FY 2001-2003 $7,279,347 $6,010,421 $5,536,540 2001 Q U EST 2002 2003 2001 Total revenue—research Total revenue—hospital TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 2002 2003 10 31 FACTS AND FIGURES C L I N I C A L P R O F I L E — H O S P I TA L FY 2001 Inpatient beds Surgery suites FY 2002 FY 2003 40 4 40 4 40 4 2,345 1,922 4,267 2,696 2,410 5,106 2,877 2,491 5,368 Clinical trials underway** Therapeutic Non-therapeutic Total 125 36 161 115 37 152 86 40 126 Clinical trial accruals Therapeutic Non-therapeutic Total 210 122 332 305 278 583 257 261 518 Inpatient admissions (Figure 8) 1,040 1,017 1,114 Hospital days Inpatient Observation Total 7,192 2,775 9,967 7,293 3,075 10,368 7,484 2,816 10,300 27.3 6.9 169,487 2,592 10,147 4,085 28.4 7.2 175,792 2,793 10,848 3,992 28 7.0 174,210 2,794 9,858 4,445 47% 24% 13% 6% 10% 46% 23% 15% 6% 9% 45% 25% 16% 5% 9% Patient volume* (Figure 7) New cancer patients treated at UM Hospital and Clinics New cancer patients supervised by UM faculty at Jackson Memorial Hospital Total Average daily census Average length of stay Outpatient visits (Figure 9) Surgical cases (Figure 10) Patients receiving chemotherapy Patients receiving radiation therapy Patient base demographics % from Miami-Dade % from Broward % from Palm Beach % International % Other *Patient volume as reported to the State of Florida; data are one year behind. **During FY 2003, all clinical trials were carefully reviewed. Those that did not meet stringent standards for scientific merit and those that were not accruing subjects in a timely fashion were closed. N E W PAT I E N T V O L U M E I N P AT I E N T A D M I S S I O N S — H O S P I TA L FIGURE 7 FY 2001-2003 FIGURE 8 FY 2001-2003 (As reported to State of Florida; data are one year behind) 1,114 1,040 2001 2002 2003 New cancer patients supervised by UM faculty at Jackson Memorial Hospital New cancer patients treated at UM Hospital and Clinics O U T PAT I E N T V I S I T S — H O S P I TA L FIGURE 9 2001 1,017 2002 2003 S U R G I C A L C A S E S — H O S P I TA L FY 2001-2003 FIGURE 10 FY 2001-2003 175,792 2,793 2,794 2002 2003 174,210 2,592 169,487 2001 10 32 2002 Q U EST 2003 2001 TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER UM/SYLVESTER LAUNCHES NEW WEB SITE W e have some exciting news! Later this year we will be launching our new web site at www. sylvester.org. We are very proud of our efforts to make this site informative and easy to read and understand. On the UM/Sylvester site you will have a chance to meet some of the “names and faces” that work with us every day, and learn how you can help in our search for a cure. Please check in from time to time so that you’re “first in line” for the launch. QUEST Editor Felicia Lopez-Walker, M.S.B. Design Sabia Communications Inc. Photography Steve Gold, Donna Victor, and UM School of Medicine Biomedical Communications On the Cover The Sylvester Family Direct inquiries to: Published by the Office of Marketing and UM/Sylvester Marketing and Communications for patients, donors, and Communications friends of the University of Miami 1475 N.W. 12th Avenue, Suite C002 Sylvester Comprehensive Cancer Center. Miami, Florida 33136 All contents ©2003, University of Miami. Telephone: 305-243-4302 Contents may be reproduced by Fax: 305-243-4146 permission from the editor and if E-mail: flopez1@miami.edu appropriate credit is given. P AT I E N T P R I V A C Y P R O T E C T E D Of the many types of personal information, health information is among the most sensitive. The Health Insurance Portability and Accountability Act of 1996 (known as HIPAA) is federal legislation that protects the privacy and security of patients’ health information (referred to as PHI). The new privacy rules, which took effect April 14, 2003, assure that patient’s sensitive health information will be kept confidential. The University of Miami Sylvester Comprehensive Cancer Center is committed to protecting the information of its patients. A central privacy office has been established to facilitate all patient rights requests and promote a culture of privacy at UM/Sylvester. The privacy office can be reached at 305-243-5000 or by email at privacy@miami.edu. With these measures in place, patients can be confident that their privacy and confidentiality will be protected. If you do not wish to receive Quest in the future, please send your request in writing to the University of Miami Privacy Office, P.O. Box 019132 (M-379), Miami, Florida 33101. Q U EST TH E M A G AZIN E O F TH E U N IVER SITY O F MIA MI SYL VES TER C O MPR EH EN SIV E CA N CER CE N TER 10