Big Ideas: Commercializing Oregon`s Nanoscience Research

Big Ideas: Commercializing
Oregon’s Nanoscience Research
November 15, 2011
Robert D. “Skip” Rung
President and Executive Director
Agenda
• What ONAMI does
– The Essential Ecosystem for Commercialization
• ONAMI’s Gap Fund Portfolio – examples
• Oregon Innovation Cluster
– ONAMI’s new EIRs
2
Signature Research Center Investment
Formula
OECDD’s 2002 study
pointed to: “multiscale
materials and devices” =
Nanoscience &
Microtechnologies
Competitive
Research
Commercial
Potential
Oregon
Industry
3
Pacific
Northwest
Micro and
Nano Industry
Assets
9 posters (3 CA, 2 MA, 2 TX,1
AZ, 1 PNW) available at
www.siliconmaps.com
Identified Research Strengths
• Microtechnology-based
Energy and Chemical
Systems
• Green Nanomaterials
and Nanomanufacturing
• Nanolaminates and
Transparent Electronics
• Nanoscale Metrology
and Nanoelectronics
6
ONAMI’s Mission and Metrics
Grow Materials Science and Device R&D
(award/contracts $$, growth rate)
Provide High-Tech Facility Access to Business
(# clients, $$ billed)
Enable Oregon tech startups to raise capital
($$ private capital, $$ leveraged grants)
7
7
ONAMI Research Award History FY02-FY10
$60,000,000
$50,000,000
$40,000,000
$30,000,000
$20,000,000
$10,000,000
$0
FY02
FY03
Research Awards
FY04
FY05
FY06
Research Expenditures
8
FY 07
FY08
FY09
State Operating Support
FY10
An NSF Center for Chemical Innovation
New Materials - Unprecedented Performance
Doug Keszler
Oregon State University
Dave Johnson
University of Oregon
$21.5M
Awarded
from NSF
Oct. 2011!!
Small
Businesses
Startup
Companies
open
fast access
responsive
client friendly
close by
Large
Industry
Education,
Research
well maintained
The “High Tech Extension” Concept
Nanoscience facilities and equipment can best benefit technology development when
they are conveniently located and easy to use by businesses. Such access is especially important to
the small and medium enterprises (SMEs) that are critical for early stage commercialization. State
and regional economic development field staff can serve as “high tech extension” agents.
10
ONAMI Shared User Facilities
Center for Materials Characterization (CAMCOR)
CAMCOR is a full-service, comprehensive materials characterization
center at the University of Oregon (UO) open to outside clients.
Benefit from capabilities, access to analytical experts, priority for time
critical data, and remote access from your office. Equipment includes:
Transmission electron microscope (TEM), Field emission Scanning
electron microscope (SEM), SEM/FIB nanofabrication, Electron
Microprobe Analysis (EPMA), X-ray photoelectron spectrometer
(XPS), Time-of-Flight Secondary Ion Mass Spectrometer (ToF-SIMS),
Single crystal and powder diffractometers, and more.
CAMCOR is located in the
Lorry Lokey Science
Complex, University of
Oregon
View inside the CAMCOR
Surface analytical
laboratory and the X-ray
photoelectron
spectrometer (XPS)
CEMN is located in the
heart of Portland
Transmission electron
micrograph of virus
particles.
The MBI is managed by
Oregon State University
and located on the HP
Corvallis campus.
ESI laser machining tool at
the MBI facility.
Center for Electron Microscopy and Nanofabrication (CEMN)
The CEMN at Portland State University (PSU) provides researchers
and industry with state-of-the-art facilities for characterization and
fabrication of nanoscale materials and devices. Equipment includes:
Transmission electron microscope (TEM), Field emission Scanning
electron microscope (SEM), SEM/FIB nanofabrication, thin film
deposition and sample preparation.
Microproducts Breakthrough institute (MBI)
The MBI is a microsystems fabrication facility located on the Hewlett
Packard (HP) campus in Corvallis. Through miniaturization,
microtechnology has the potential to revolutionize many products.
The MBI uses microfabrication methods to support researchers and
industry to invent and prototype products for energy, environmental,
medical and defense applications. Applications include, blood
processing, fuel injection, DNA sample preparation, nanomaterial
deposition, and microchannel heat exchangers.
11
Product development execution
Global market intelligence
Organizational roles/needs in technology commercialization:
Research Institutions: scientific discovery, fundamental invention, talent
development, shared user facilities. Need: public and philanthropic funding,
enabling regulatory/legal environment
Startup companies: pioneering technology and market development of small but disruptive – first opportunities. Need: equity/royalty licenses, large company
customers/partners, high-risk (early stage) capital, minimal regulatory/legal
burdens
Large companies: Manufacturing scale-up and global business development.
Need: large & profitable “mainstream” markets, low-risk technology options
The ONAMI Commercialization
Gap Fund Concept
Company
Stage
Funding
Source
Research
Result
(NA)
NNI
Grants
Proven
Prototype
Formation
Products,
Sales
Development
Early Stage
Investors
Product Line
Expansion
Growth
Various
Research
Team,
Idea
Gap Grants
(state +
federal)
Entrepreneur,
Market Need
Gap Project
Technology
Stage
“Investable”
Company:
•Large Opportunity
•Competitive Edge
•Solid Mgmt Team
•Sound Plan
(private)
Federal/state partnerships in “gap” (aka “valley of death”) funding for new ventures commercializing NNI technology could
accelerate commercialization by 2-4 years and also ensure proper focus on economic returns and job creation.
13
Review: ONAMI’s Role in Technology
Commercialization
ONAMI
/Government
Grants
Research
ONAMI
Gap Grants
Early Stage
Funds
Investor
funded
Proof of
Concept
Product
Proof
Revenue
Generation
Self or
Investor
funded
Growth /
Cash
Generation
Focus on interfaces and operations
The ONAMI Gap Fund Portfolio, November 2011
http://www.onami.us/Commercialization/currentProjects.php
Thrust Area
and Project
Host
Campus
MECS
OSU
Home Dialysis Plus
Inpria
Peregrine/Promat
ABP
Nanobits
OnTo Technology
Mtek Energy
CNXL
Green Nano
(microtech(materials and
based energy and processes)
chemical
systems)
Trillium Fiberfuels
Apex Drive Labs
NWUAV
Mtek desal
Nanoscale
Metrology
Nano BioTech
ZAPS
Technologies
NWMI
Pacific Light
Technologies
Flash Sensor
DesignMedix
Perpetua Power
NemaMetrics
Solid State
(batteries, printed
electronics, green
electronic
materials)
Voxtel Nano
CSD Nano
Microflow
Applied Exergy
PSU/OHSU
UO
Puralytics
Crystal Clear
Technologies
Dune Sciences
$103M leverage to date,15more pending
PDX Pharma
Floragenex
A Green Nano Startup Portfolio
Green NanoMaterial
Green NanoManufacture
Green Nano
Application
Safer Design
Reduce eimpact
Waste
Reduction
Process
Safety
Materials
Efficiency
Energy/H2O
Efficiency
16
16
Platform to directly assess nanoparticle fate and
transformations
Thermal SiO2
Si
3 mm
10-30 μ
μm
www.dunesciences.com
Dune Sciences
Nanoparticle Capture for
Visualization and Surface Functionalization
LinkedON™ Technology
• Permanent bonding of nanoparticles to surfaces.
• Reduces environmental impact and footprint.
Nanoparticle Adhesion
Durable anti‐microbial coatings.
Smart Grids™
• New standards for nano‐
particle metrology.
• Better understanding of nanomaterial risks.
• Enhanced imaging of biomolecules for research and diagnostics.
18
nanoSilver coatings – Reducing product
environmental footprint through nanotechnology
 High efficacy against odor-causing bacteria increases
product life and reduces total silver needed
 Durable coating lasts the lifetime of the garment
 Permanent bonding of silver prevents free silver NP
release
 Aqueous, low T process, non-toxic ingredients
 High utilization of silver nanoparticles
What about the fate of the AgNPs on the surface?
Silver NP fate is typically determined indirectly
by monitoring silver loss or retention
Environ. Sci. Technol., 2008, 42 (11), 4133-4139
and data from Dune Sciences
Inpria Corporation (Corvallis, OR)
Inpria develops materials that
enable vacuum-quality metal
oxide thin films with the speed
and low cost of solution
processing
Al Dielectric
325 nm
Thermal SiO2
1.6 nm TiO2
IGZO
150 nm
Hf dielectric
Broad Platform
Adaptable to
Many Applications
Al dielectric
21
Initial Products: Lithography Resists
with Extremely High Etch Resistance
15nm Etched Si Fins
1.6 nm Linewidth
Roughness @ 30nm
High resolution resist for
EUV Lithography: 15 nm l/s
22
Mixing
Growth
Purification
•
Green Aspects
o Reduced Waste
o Increased Yield
o Elimination of Heavy Metals (Pb, Hg, Cd)
Nucleation
•
o Reduced Cost
o Increased Process Control
(Particles of known size, shape and chemistry)
Zoned / Modular Reactor enabling:
• Process Control / Monitoring at each zone
• New chemistries not available to batch processes
• Increased scientific understanding of each step in nanoparticle synthesis (nucleation, growth, ligand exchange)
Business Aspects
•
Green Performance and Business Success are compatible.
Photovoltaics
Demonstrated 200% efficiency through MEG (multiple exciton process)
Photoreceivers
• Night vision goggles
• Improved ergonomics
• Reduced spatial footprint (eyeglass form factor)
• Cameras – Printed Electronics
Security / Anti‐Counterfeiting
• Increased difficulty for reverse engineering
• Increased degree of encryption (>106/pixel)
• Incorporates time resolved emission as another encryption method.
• Covert Taggants
• Allows tracking and identification of unwilling targets at long stand‐off distances
• Allows tagging and identification of munitions / suppliers
Detectors
• Sensors for large area x‐rays and g‐rays
• Built in spectrometer through wavelength selective absorption
• Cost effective detection of near infrared / short wavelength infrared
Biosensing
• Allows selective detection and identification of chemical and biohazards.
• Anthrax, E. coli, Salmonella, Ricin
Displays
• Incorporated in NQD‐LEDs for highly emissive, high color purity displays
Carbon Nanotubes
• Flow Cell Reactor principles also being applied to synthesis of highly purified, monochiral CNTs.
• (4‐hour process versus 2‐3 week process)
The World Needs Solid State Lighting
Worldwide Electricity Consumption
Lighting: 27% 4.7B KWh in 2009
Other: 73%
Photo Source: NASA
Solid State Lighting Will:
• Save a cumulative 5T kWh of electricity WW in the next decade,
• Remove the need for 500 power plants from the grid
• Reduce cumulative tons of CO2 emissions by 8B tons (equal to the emissions from all of the passenger cars in the world)
Source: Canaccord Genuity
27
Pacific Light Technology
efficient lighting through engineered nanomaterials
High Efficiency Blue LEDs
Quantum Dot
“Down Converters”
White Light
SSL Bulbs Today Reduce Electricity Usage by:
• 80% vs. Filament Bulbs (But initial price is 2‐3x too high)
• 10‐20% vs. Florescent (Not sufficient)
PLT’s High Efficiency QD Down Converters Will:
• Reduce Cost by Reducing Number of LEDs (20‐50%)
• Reduce SSL “Florescent” Electricity Usage by another 20‐50%
• Improve Stability of Color (no objectionable CFL color “shifts”)
Green, Lean, and Mean
Mark Owen, CEO
Beaverton, OR
www.puralytics.com
29
 Novel LED-activated nanotechnology
coated mesh for water purification
 Green:
 Water and electricity reduced
 Contaminants destroyed
 Lean:
 Operating Expenses reduced 80%
 18 Month Payback
Shield 500 – world’s
first solid state water
purification system
 Mean:
 Eliminates contaminants competitive
systems can’t
LEDs excite a nanotechnology coated mesh
which destroys germs and chemicals
4 Patent Apps Filed, 3 Grants, Field tests successful
31
Shield #113 Performance
Fraction Removed at 500 gal/day
100%
80%
60%
40%
20%
0%
Caffeine (4 ppm)
MTBE (1 ppm)
32
Photocatalytic Oxidation
Photocatalytic Reduction
Photolysis
Photoadsorption
Photo Disinfection
33
Award-Winning Power Pucks®
Life-long, renewable battery for
powering Wireless Sensor Networks
•
Renewable energy from waste heat
• Eliminates batteries
• Like a battery – constant voltage
• Easy installation
© 2010, 2011 Perpetua Power Source Technologies, Inc.
Contact Information
Perpetua Power Source Technologies, Inc.
Nicholas Fowler, Chairman & CEO
4314 SW Research Way
Corvallis, OR 97333 USA
Telephone:
541.223.3112
Fax:
253.399.0373
Email:
nff@perpetuapower.com
Web site:
www.perpetuapower.com
Perpetua Power Puck®
Renewable energy solutions for wireless sensors.
© 2010, 2011 Perpetua Power Source Technologies, Inc.
Oregon Innovation Cluster
Economic Development Administration i6 Challenge Award Winners
Presentation to OIC Advisory Committee
October 7, 2011
Patricia Beckmann, PhD
David Kenney
Skip Rung
Oregon Translational Research & Drug Development Institute
Oregon Built Environment & Sustainable Technologies Center
Oregon Nanoscience and Microtechnologies Institute
1
Technical & Business Assistance Services
 Provide coaching on entrepreneurial success factors and commercialization to at least 65 start‐ups across the state.
 Facilitate the writing of at least 16 SBIR/STTR grants, R&D plans and business plans.  Guide concepts through value proposition and investment development and to venture capital through match‐making
 Increase accessibility of relevant expertise in business and legal services
 Optimize strategic networking opportunities
 Impact statewide – beyond Portland Metro, and beyond Willamette Valley
2
Proof‐of‐Concept Grants

Share best practices for management of proof‐of‐concept development projects.

Improve success of proof‐of‐concept project teams through monitoring and mentoring.

Increase use of shared lab and fabrication facilities and test for proof‐of‐concept projects. 
Increase number and quality of University/Industry collaborative projects.
ONAMI Entrepreneurs In Residence
Team, Network, Marketand Sales assistance from veteran CEOs
Augie Sick asick@onami.us
 Chemistry, nanomaterials, life science tools
Michael Tippie mtippie@onami.us
 Biomedical, pharma, nanomedicine
John Brewer jbrewer@onami.us
 Semiconductors, electronics, optics
39
39
Summary: What it Takes
• Solid research base
• Successful industry cluster & workforce
• Locally and professionally managed gap &
seed funding
• Local executive talent base and mentoring
for new entrepreneurs and teams
40