Anju Usman - 4.22.16 Gut Restoration SH (1)

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Gut Restoration
Seeking Health Conference
Anju I. Usman, M.D.
True Health Medical Center
Naperville, Illinois
#SHEICON2016
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DISCLAIMER: THIS PRESENTATION DOES NOT PROVIDE MEDICAL ADVICE
The information, including but not limited to, text, graphics, images and other material contained in this presentation are for informational
purposes only. The purpose of this conference is to provide an understanding and knowledge of various health topics. It is not intended to be a
substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care
provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and
never disregard professional medical advice or delay in seeking it because of something you have encountered in this presentation.
SHEI does not recommend or endorse any specific tests, physicians, products, procedures, opinions or other information that may be
mentioned in this presentation. Reliance on any information appearing in this presentation is solely at your own risk
#SHEICON2016
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Disclaimer
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Information is for educational purposes only
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The alternative view presented has not been established as standard care or practice
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Clinical trials have not yet been conducted
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Not to be taken as specific medical advice
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Dr. Usman is medical director of True Health Medical Center and Pure Compounding Pharmacy
#SHEICON2016
Reconstituting the Depleted Biome to
Prevent Immune Disorders
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Article By William Parker, Duke University
“The light of evolution points toward reconstitution of the biome as the only
reasonable therapy for a wide range of immune-associated disorders,
including allergy, autoimmunity and perhaps autism.”
#SHEICON2016
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Evolution, Medicine and Public Health, 2013
#SHEICON2016
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#SHEICON2016
Human Microbiome Project
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5yr/ $140 million effort to study and explore how the trillions of microscopic
organisms in our bodies affect our health.
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Total microbial cells found in association with humans may exceed the total
number of cells making up the human body by a factor of 10:1.
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The total number of genes associated with the human microbiome could
exceed the total number of human genes by a factor of 100:1. Organisms
found include bacteria, yeast, protozoa, parasites, viruses and bacteriophages
#SHEICON2016
100 trillion bacteria Atleast 1,000 different species
Early disruption of gut flora affects
later immune function causing
potential allergies and
autoimmunity
Good flora protects us from
pathogens
Aids with digestion of
carbohydrates and fiber to form
SCFA which in turn fuels
enterocytes
#SHEICON2016
Gut Microbiota
#SHEICON2016
#SHEICON2016
Nature Reviews Neuroscience 2012
Mice, Microbes and Antibiotics
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Dr. Vincent Young, University of Michigan (2009)
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“the gut ecosystem needs to be preserved and that changing the ecosystem
through stresses such as antibiotics could irreversibly change the ecosystem,
with deleterious effects.”
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He found that mice when given particularly strong antibiotics completely wiped
out all their normal gut microbes.
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Even more striking, Clostridium species and fungal species are then able to
overgrow without the good bacteria there to fend them off.
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Once the bad bugs take hold in our GI tract they may be extremely difficult to
eradicate.
#SHEICON2016
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#SHEICON2016
Tryptophan and IDO
Serotonin
Melatonin
5HTP
BBB
Tryptophan
Proinflammatory
IDO
TDO
Cytokines
(liver)
NAD+
Kynurenine
Quinolinate
Quinolinic
Kyrurenic
IDO= indole amine dioxygenase
#SHEICON2016
TDO=tryptophan dioxygenase
ATP
Tyrosine/Dopamine Metabolism and Gut Bugs
Benzoic acid
Hippuric
Phenylalanine
PAL
Gut Bugs
Phenylacetic
Tyrosine
DOPA
Phenols (p-cresol)
Ammonia
X
DBH
HVA and
other metabolites
Dopamine
Norepinephrine
VMA
Epinephrine
Theory: sulfation of excess phenols causes depletion of sulfate
#SHEICON2016
Leaky Gut and Gluten
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Gluten causes leaky gut by releasing zonulin
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Zonulin release causes cytokine and chemokine activation (CXCR-3 , ligands CXCL
9, 10, 11) and migration of pathological Th1 cells
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Gluten causes wbc (neutrophil) recruitment
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An impaired intestinal barrier is involved in INFLAMMATION
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MS, strokes, asthma, cardiomyopathy, IDDM, thyroiditis, celiec disease, rheumatoid
arthritis, inflammatory bowel disease and Autism
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Anti-zonulin Therapy is being studied
#SHEICON2016
Human Zonulin a Potential Modulator of Intestinal Tight
Junctions Fasano
Mechanisms of Disease: the role of intestinal
barrier function in the pathogenesis of
gastrointestinal autoimmune diseases
Nature Clinical Practice Gastroenterology &
Hepatology (2005) 2, 416-422 Alessio Fasano
#SHEICON2016
PANDAS/PITANDS
Pediatric Autoimmune Neuropsychiatric Disorder Triggered by Streptococcus or Other Infections
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Presence of obsessive-compulsive disorder and/or a tic disorder or acute behavioral changes
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Pediatric onset of symptoms
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Episodic course of symptom severity
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Association with group A Beta-hemolytic streptococcal infection (a positive throat culture for Strep or history of
Scarlet Fever)
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Triggered by other infections (Lyme, Bartonella, Mycoplasma, Viruses…)
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Association with neurological abnormalities (motoric hyperactivity, or adventitious movements, such as
choreiform movements)
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Acute change in behavior, skills (handwriting), bladder control
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Elevated CAM kinase and tyrosine hydroxylase, dopamine upregulation, and autoimmunity (M. Cunningham,
Univ of
Oklahoma)
#SHEICON2016
From Research Subgroup to Clinical Syndrome:
Modifying the PANDAS Criteria to Describe PANS
(Pediatric Acute-onset Neuropsychiatric
Syndrome)
Susan E. Swedo. NIH 2013
#SHEICON2016
Inflammation, Infections, Stress and the
BBB
The blood-barrier can be
compromised by inflammation,
infections, stress, histamine, and
hormones allowing antibodies to
enter and affect certain parts of the
brain.
Infectious moods: Bugs that cause bizarre
behavior
12 January 2011 by Linda Geddes
#SHEICON2016
The blood-brain barrier (green) turns
out to be leaky
Basic Biomedical Strategy
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History and Physical Examination
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Laboratory Testing
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Clean Up
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Environment
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Diet
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GUT!!!!!!!!!!!!!!!!!!!
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Foundational Nutrients
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Address HPA axis and Dysautonomia
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Support Detoxification Pathways, esp. Methylation and Sulfation
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Address Mitochondrial Dysfunction
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Heavy Metal/Chemical Detoxification
#SHEICON2016
History - Gastrointestinal
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History of Colic
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Reflux
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Frequent or Early Antibiotics
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Dairy Intolerance, Sugar Cravings
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Frequent Otitis Media or Sinusitis
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History of Thrush, Severe Diaper Rash
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Poorly Formed Stools, Odd Color, Consistency, Odor
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Soft serve stools
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Undigested Food in Stools, Floating Stools
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Constipation, Chronic Diarrhea, Both
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Abdominal Distention, Gassiness, Bloating
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Abnormal Posturing
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Self Injurious Behavior, Aggression
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Poor Sleeping Habits
#SHEICON2016
Clean up the Environment
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Use natural, biodegradable and perfume free detergents and cleaning agents, do not dry clean clothes.
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Avoid chlorine: use water filters, limit pool and hot tubs.
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Wear 100% cotton clothes, avoid flame retardants. (Sb)
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Use fluoride-free toothpaste (tin,titanium).
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Use an air purifier, especially in the bedroom.
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Avoid prolonged exposure to batteries (light up shoes, lap tops, cell phones, head phones).
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Check for recalled TOYS with lead.
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Use aluminum-free salt, baking powder, deodorant. Do not cook in aluminum foil or drink from
aluminum cans.
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Avoid use of herbicides or pesticides or mosquito repellants, on lawns, garden, or self(remove shoes
when home).
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Use natural shampoos, soaps, and make-up (lipstick-Pb/Al)
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Avoid sources of electrosmog/(EMF), especially in the bedroom. (cordless phones, wi-fi, baby monitors)
#SHEICON2016
Clean up the Diet
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Casein-free/Gluten-free/Soy-free Diet Trial for 3-6 months.
Avoid sugar and refined starch, high fiber diet, maximize antioxidants,
cruciferous veggies, turmeric, garlic…
Limit processed and preserved foods; organic is best.
Avoid excitotoxins (ex. Caffeine, MSG, NutraSweet, red/yellow food dyes,
nitrites, sulfites, glutamates, preservatives).
Drink plenty of clean filtered water.
Begin meals with raw fruits and veggies.
Add good fats (cold pressed, hexane-free) – oils, nuts, seeds.
Avoid hydrogenated, trans-fats, fried or heated fats.
Buy hormone-free, antibiotic-free, organic, GMO-free especially animal
products such as eggs, meat and dairy.
Add fermented foods (coconut kefir, cabbage, kombucha).
#SHEICON2016
Dietary Detours
CF/GF Diet
Persistent Gut Issues
Hyperactivity/Stimming
Specific
Carbohydrate
Diet
Avoid Excitotoxins
SIBO/FODMAPs
Diet
Low Phenolic/Feingold
Diet
Low Oxalate
Diet
Low Copper Diet
GAPs/Paleo
Elimination/Rotation
Diet
#SHEICON2016
Lab Options for Gut Issues
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Urine Organic Acids Test (OATS, MAP)
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Stool Microbiology
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Stool Mycology
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Stool Parasitology
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IgG/IgE Food/Mold Antibody Panel
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Celiac Panel, Carnitine level, Acyl carnitine Panel, Vit D25 OH, retinol
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Ammonia - blood, urine
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Fecal Fat
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Xray – KUB
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Oxalate- 24 hr urine or random
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Breath Test for Fructose Malabsorption, SIBO (methane or hydrogen)
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Inflammatory Markers (ESR, CRP, histamine, calprotectin,…)
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IBD Serology (prometheus testing)
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Endoscopy, Colonoscopy if necessary
#SHEICON2016
Gut Clean Up Strategies
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Address Maldigestion
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Add Digestive Enzymes
Address Malabsorption
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Add Probiotics, Essential Fatty Acids
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Address Fat Soluble Vitamin Deficiencies (A, D, E, K)
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Address Essential Amino Acid Deficiencies
Address Dysbiosis, SIBO and Pathogenic Biofilms
#SHEICON2016
Gut Clean Up Strategies
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Diagnose and Treat Immune Dysregulation
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Address Food Hypersensitivities – Diet, SLIT, LDA
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Treat Immunodeficiencies
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Address Chronic Inflammation
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Address Motility/Constipation
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Address High Oxalates
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Vit D, Vit K, Vit B6, Vit B1, Mb, Biotin, Calcium citrate,
Magnesium citrate, LOD (low oxalate diet)
#SHEICON2016
Addressing Maldigestion
Digestive Enzymes
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Enzyme activity is dependent on specific cofactors and coenzymes(vitamins/minerals)
and pH
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Enzyme activity can be inhibited by toxins, fungi, oxidative stress, and malnutrition
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Enzyme activity can be optimized with proper nutrition and elimination of toxins
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Ex. DDP4 enzyme activity inhibited by Hg
#SHEICON2016
Enzymes
Protein
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Hydrochloric Acid- protein
digestion in stomach
Pepsin
Protease
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Peptidase
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Nuclease
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Trypsin
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Carbohydrates
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Amylase
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Lactase
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Maltase
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Sucrase
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Saccharidase
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Disaccharidase
Lipids/Fats
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Lipase
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Bile Acids (emulsify fat)
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Glycocholic acid
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Taurocholic acid
Enzyme Supplements
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Bromelain- Papaya and Pineapple breaks down protein
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Plant Based Enzymes – Aspergillus derived
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Lumbrokinase- earth worm
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Nattokinase- soy
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Serrapeptase- silk worm
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Carnivora- venus fly trap
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Pancreatic glandular
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Prescription enzymes- Pancrealipase
#SHEICON2016
Probiotics
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Remain viable and stable after culture, manipulation, and storage
Survive gastric, biliary and pancreatic digestion
Able to induce a host response once they enter the intestinal
microbial ecosystem
Transiently colonize or occupy the gut
Not all viable ingested bacteria in the food supply are probiotics
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Live microorganisms which when administered in adequate
amounts confer a health benefit on the host
-WHO 2001
#SHEICON2016
Success of Probiotics
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Safety
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Adhere to intestinal mucosa for transient colonization
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Proven health benefit
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Antimicrobial (lactic acid bacteria)
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Anticarcinogenic (1,2 dimethylhydrazine tumors)
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Survival in the product
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Needs a food source (prebiotic stimulation)
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Using compatible bacteria together (lactobacillus plantarum not compatible with bifido)
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Dosing 10 – 10 cfu, overdosing not possible
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Probiotics may be an issue in patients with inflammatory bowel disease and in patients with SIBO
#SHEICON2016
Lactobacillus and Bifidiobacteria
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L. casei, bulgaricus, and acidophilus increase macrophage and enhance
phagocytosis
Decrease gut permeability
Exert antimicrobial activities
Secrete antimicrobial proteins (activate mucin, MUC2 and MUC3 genes)
Increase T helper cells, Th2
Decrease Th1, and allergic response
Increase IL 10, TGFbeta
Bifidio lowers proinflammatory cytokines
Lactobacillus is highly populated in the small intestines,
Bifido is highly populated in the large intestines
#SHEICON2016
Probiotics to Prevent the Need For, and Augment the
Use Of, Antibiotics
Can J Infect Dis Med Microbiol. 2006 Sept
Gregor Reid, BSc, PhD MBA
● Reduce the risk of antibiotic-induced super infections in the gut and
the vagina.
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Secrete antibacterial substances that lower pathogenic bacterial
populations locally and at distant mucosal sites, and disrupt biofilms,
making it easier for antibiotics to function.
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Enhance generalized mucosal immunity, which in turn aids in the
eradication of the organisms at the mucosal site.
#SHEICON2016
Ingestion of Lactobacillus Strain Regulates Emotional
Behavior and Central GABA Receptor Expression in a
Mouse Via the Vagus Nerve
Bravo. Aug 2011
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Chronic treatment with L. rhamnosus (JB-1) induced region-dependent alterations in
GABA(B1b) mRNA in the brain
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L. rhamnosus (JB-1) reduced GABA(Aα2) mRNA expression in the prefrontal
cortex and amygdala, but increased GABA(Aα2) in the hippocampus.
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L. rhamnosus (JB-1) reduced stress-induced corticosterone and anxiety- and
depression-related behavior.
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The neurochemical and behavioral effects were not found in vagotomized mice.
#SHEICON2016
L. acidophilus and salivarius may help with
pain perception
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Oral administration induced a sustained release of the expression of
analgesic opioid and cannabinoid receptors in humans.
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Direct contact of NCFM with epithelial cells is able to induce, through
the NF kappa beta pathway, MOR1 and CB2 expression and contribute
to the modulation and restoration of the normal perception of pain.
#SHEICON2016
Prebiotics
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Fibers (non-digestible) that are a food source for good bacteria
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Bifidobacteria ferment this to make short chain fatty acids(SCFA)
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SCFA help feed and fuel the cells of the colon, prevent dysbiosis and inflammation in the gut
Probiotics, prebiotics, and synbiotics
#SHEICON2016
De Vrese. 2008
Prebiotic Health Benefits
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Enhance absorption of minerals such as calcium, magnesium
and iron
Promote bowel motility and regularity
Inhibit growth of cancerous lesions in the GI tract
Improve immune function
Lower blood cholesterol
Slow digestion of carbohydrates/sugar
Goal: 5-15 grams/day
#SHEICON2016
Sources of Prebiotics
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Food Sources:
Artichokes, garlic, onions, leeks, asparagus, chives
legumes, soybeans, peas, chicory root, oatmeal, flax,
bananas
Supplements:
● Inulin
● Fructooligosaccharides, galacto-oligosaccharides
● Larch arabinogalactan
● Guar gum
● Polydextrose
● Maltodextrin
● Lactulose
#SHEICON2016
Improving Motility
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5HTP
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Acetyl L Carnitine
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Iberogast
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Cholinergic Agents
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Phosphatidyl Choline
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Urecholine
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Vitamin C, Mg citrate
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Triphala, Aloe, Senna
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Address Oxalates- Consider B6, Biotin, Mb, Calcium citrate
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Address Metal Burden especially Lead (Pb) and Aluminum (Al)
#SHEICON2016
If it takes greater than 24 hrs to
pass charcoal or beets, consider
a motility issue!
Check a KUB
Remember constipation may
mask as intermittent diarrhea
Our whole life is solving puzzles. ~Erno Rubik
#SHEICON2016
What is Biofilm?
A biofilm is a collection of microbial communities
enclosed by a matrix of extracellular polymeric
substance (EPS) and separated by a network of
open water channels.
Their architecture is an optimal environment for
cell-cell interactions, including the intercellular
exchange of genetic material, communication
signals, and metabolites, which enables diffusion
of necessary nutrients to the biofilm community.
The matrix is composed of a negatively charged
polysaccharide substance, held together with
positively charged metal ions (calcium,
magnesium, and iron).
Staphylococcus aureus biofilm
#SHEICON2016
The matrix in which microbes in a biofilm are
embedded protects them from UV exposure, metal
toxicity, acid exposure, dehydration salinity,
phagocytosis, antibiotics, antimicrobial agents and
the immune system.
Where do they grow?
Biofilm formation appears common near polluted and toxic
areas and environments.
Account for the majority of all microbial infections of the
human body.
Device-related infections,
intravenous catheters,
joint prostheses
Human body –
Mouth, teeth, pancreaticbiliary tracts, lungs,
sinuses, adenoids,
tonsils #SHEICON2016
and the intestinal tract….
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Biofilm/Slime!
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Difficult to Treat
Remarkably difficult to treat with antimicrobials, resistant to doses of
antimicrobials 100- to 1000-fold
Antibiotics do not penetrate the polysaccharide matrix.
Difficult to diagnose, difficult to culture.
Microbes impart genetic material to one another to maintain resistance.
Colonies communicate with one another through the use of quorum sensing
molecules.
Colonies fail to express OMP (outer membrane proteins).
“Testing the Susceptibility of Bacteria in Biofilms to Antibacterial Agents” Antimicrobial Agents and Chemo.
Nov 1990.
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Potential Biofilm Control Strategies
Probiotics and Prebiotics and Synbiotics
NaEDTA
Iron chelating compounds
Enzymes – mucous/fibrin degrading
Chitosans
Surfactants
#SHEICON2016
The Efficacy of EDTA
Against Biofilm Bacteria
(Kim, 2005)
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Biofilms = complex communities of micro-organisms attached to surfaces held
together by EPS (extracellular polysaccharides, that are negatively charged and
held together by positively charged cations, specifically Fe2+, Ca2+, and Mg2+.
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EDTA complexes with cations in the extracellular matrix.
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Neither Vancomycin or EDTA alone detached Staph biofilm.
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EDTA plus Vancomycin together caused biomass removal.
#SHEICON2016
Chelator-Induced Dispersal and Killing of
Pseudomonas aeruginosa Cells in a Biofilm
(Banin, 2005)
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EDTA is a potent Pseudomonas biofilm disrupter.
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1000x killing when EDTA combined with Gentamicin.
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EDTA causes dispersal and killing of biofilm cells.
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Ca, Fe, and Mg protect biofilm.
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When Ca or Fe are added, killing and detachment are completely blocked.
#SHEICON2016
A Component of Innate Immunity Prevents Bacterial
Biofilm Development
Nature. 2002 May 30;417(6888):552-5.
Singh PK, Parsek MR, Greenberg EP, Welsh MJ.
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Antimicrobial factors form one arm of the innate immune system, which protects mucosal
surfaces from bacterial infection.
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Lactoferrin, a ubiquitous and abundant constituent of human external secretions, blocks
biofilm development.
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By chelating iron, lactoferrin stimulates twitching, a specialized form of surface motility,
causing the bacteria to wander across the surface instead of forming cell clusters and biofilms.
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These findings reveal a specific anti-biofilm defense mechanism acting at a critical juncture in
biofilm development, the time bacteria stop roaming as individuals and aggregate into durable
communities.
#SHEICON2016
The effects of lactoferrin on P. aeruginosa biofilms
after three days.
Left image: Without lactoferrin, the cells congregate.
Right image: With lactoferrin, the cells wander freely. ©Nature #SHEICON2016
Treating Dysbiosis and Chronic Infections
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Clostridia
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Yeast
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Bacteria and Strep
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Parasites
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Viruses
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Lyme and Co-infections
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SIBO
#SHEICON2016
True Health Medical Center
Gut Biofilm/Dysbiosis Approach
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Step 1 Lysis/Detachment – empty stomach
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Step 2 Microbial Killing – 15-30 min later
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Step 3 Clean up – 2hr later and/or at night
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Step 4 Rebuilding/Nourishing the Gut Lining
#SHEICON2016
Step 1: Lysis/Detachment
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Enzymes
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Polysaccharidase, Disaccharidase –mucolytic
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Fibrinolytic
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Careful with proteases on an empty stomach
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Disodium EDTA (oral only) or Apple Cider Vinegar
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Lactoferrin (especially for Pseudomonas, do not give if dairy allergy)
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Natural Iron Chelators (green tea, rice bran IP6, curcumin)
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Oxidative Therapies
#SHEICON2016
Step 1: Lysis/Detachment •
Works best on an empty stomach
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Do not give Enzymes on an empty stomach to patients with severe GI issues
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Do not give Lactoferrin to patients with dairy allergy
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Avoid giving Iron, Calcium or Magnesium within an hour or two of protocol
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Careful with sensitive patients or weak patients
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Careful with patients with severe autoimmunity
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Go slow, ease into enzymes and chelators
#SHEICON2016
Step 2: Killing
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Consider natural Antimicrobials first
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Do not start with Pharmaceuticals
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Vary agents depending on microbiology, mycology and parasitology testing
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Dysbiosis may seem to worsen initially
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Watch for die off, treat accordingly
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Start low and go slow
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It is not always about killing the bugs, it is more important to change the
gastrointestinal environment so the bugs don’t grow! Diet is crucial.
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If dysbiosis remains persistent, address toxicity
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Treatment is usually long term
#SHEICON2016
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Never, Never, Never Give Up…
-Winston Churchill
#SHEICON2016
Symptoms
Clostridia Issues
Treatment Options
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Aggressive
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Probiotics, High Potency single strain
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OCD
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Sacchromyces Boulardii
Temper
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Antibiotics
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Agitation
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Irritable
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Vancomycin
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Metronidazole (Flagyl)
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Herbals(Bayleaf, Thyme)
Very foul stools
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Immune modulators
Mucus in stools
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HBOT
Severe diarrhea following antibiotic use
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L. Carnitine
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Oxidative Therapies
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Probiotic Enemas
#SHEICON2016
#SHEICON2016
Yeast Issues
Symptoms
Treatment Options
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Spacey
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Foggy thinking
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Inappropriate laughter
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Sugar cravings
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Poor sleep
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Frequent diaper rash
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Drugs
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History of frequent antibiotics
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Nystatin, Ampho B
Fluconazole
Itraconazole
Ketoconazole
Herbals
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Frequent urination
#SHEICON2016
Limit carbs, sugar, yeast
Probiotics
Saccharomyces Boulardii
Zinc, Molybdenum, Biotin,
MCT
Antifungals
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Grapefruit Seed Extract
Oil of Oregano, Pau d’Arco
Garlic, Samento, …
Enzymes
Homeopathics
CPPX3
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Strep/Bacteria Issues
Symptoms
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Ritualistic
Treatment Options
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Repetitive
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Verbal tics
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Obsessive
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Compulsive
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Verbal stims
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Frequent strep infections
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Frequent bacterial infections
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Chronic inflammatory conditions
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#SHEICON2016
Probiotics
Xylitol
Antibacterial Herbs
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Goldenseal
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Neem
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Berberine
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Oregano
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Garlic
Immune modulators
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Oral Immunoglobulins- SBI
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Transfer Factors
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Colostrum
Drugs
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Antibiotics
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Non absorbed antibiotics
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Vanco, Gent, Neomycin, Rifaximin
Homeopathics
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Elevated Strep Titers/ PANDAS
#SHEICON2016
SIBO
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Symptoms
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Distention, Bloating, Gas
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Poor motility
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Constipation – Methane
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Diarrhea – Hydrogen
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Abdominal Pain
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Malabsorption
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Low Fat Soluble Vitamins
Maldigestion
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Low Total Protein/Globulin
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Low Essential Amino Acids
Gastroparesis
#SHEICON2016
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Avoid
• Fiber
• Probiotics
• Fermented Foods
• Slippery Elm, Yucca, Aloe
Diet
• SCD
• Remove disaccharides
• Fructose, Lactose, Sucrose…
• Low FODMAPs
Hydrogen
• Rifaximin
• Berberine Complex
• Neem Plus
• Oregano
Methane
• Riaximin plus Metronidazole or Neomycin
• Allicin Extract
• Neem Plus
Support Motility
Support Neurons
• Lion’s Mane
• ALA
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#SHEICON2016
Symptoms
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Parasites
Bizarre Behavior
Treatment Options
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Insatiable Appetite
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Aggressive
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Worse at full moon
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Picking, biting, licking, itching, grinding
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Fecal smearing
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Restlessness
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#SHEICON2016
Probiotics
Antiparasitic Drugs
• Flagyl
• Paromomycin
• Mebendazole, Pyrantel (non-systemic
• Ivermectin, Praziquantal (systemic)
• Alinia
Natural Remedies
• Wormwood(artemesia)
• Black Walnut
• Pumpkin Seeds
• Clove Oil
Homeopathics
• Combo remedies
Viral Burden
Symptoms
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Treatment Options
Easy Fatigue
Visual Issues
• Squinting
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• Divergent Gaze
• Poor Eye Contact
Cold sores
Warts
History of Regression after MMR or •
other live viruse
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Antiviral Agents
•
•
•
•
Olive Leaf Extract, Elderberry
Caprylic Acid
High Dose Vitamin A
Antiviral Drugs
•
•
•
•
Acyclovir
Valacyclovir
Imunovir
Amantadine
Immune Support
•
•
•
•
•
Low Dose Naltrexone
Red. Glutathione
Zinc
Immune Modulators
GcMAF
Step 3: Clean Up / Binding Agents
•
•
•
•
•
•
•
•
•
•
•
•
Fiber, insoluble/soluble (prebiotics)
Pectin, guar gum, ground flaxseeds, psyllium husks
Activated Charcoal if needed
Alginates, Brown Algae, Clay
Modified Citrus Pectin
Slippery Elm, Yucca
Burbur
Chlorella, Cilantro/Chinese Parsley
Zeolites
Chlolestyramine (binds fat soluble toxins)
Very important step
Helps prevent symptoms of die off and detox
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Step 4: Rebuilding/ Nourishing the Gut Lining
•
•
•
•
•
•
#SHEICON2016
Probiotics
Prebiotics
Probiotic/Prebiotic Rich Foods
Healing, nutritious, non-toxic foods
•
Ghee
•
Aloe
•
Ginger
•
Okra
Fermented Foods
•
Kefir
•
Kombucha
•
Cabbage
Supportive Supplements
•
Comfrey
•
Chamomile
•
Colostrum
Case Study Daniel
●
Development stopped progressing following vaccines; PDD
diagnosis age 2yrs.
●
Yeast problems & repeated ear infections.
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Began diet and basic supplements.
●
From 2.5 years to 4 years of age no improvements, sick, seemed to
get worse.
●
Seemed foggy with very delayed skills, repetitive behaviors.
●
DDx?
●
Labs?
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#SHEICON2016
Case study Daniel
•
•
•
•
•
Broad Spectrum Digestive Enzymes
Strep free probiotics and S. boulardii
SCD diet with fermented foods
Antimicrobial herbs (G+, G-, yeast, strep, virus)
• Berberine Complex
• Olive Leaf Extract
• Advanced Biocidin
Biofilm Lysis
• Biofilm Defense
•
2x/day before breakfast and dinner on an empty stomach
•
Dose ¼ to ½ adult dose depending on weight
•
3 month protocol, then usually reassess and/or retest
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#SHEICON2016
Case study Daniel
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Gut Protocol led to increased awareness, less spacey, better attention and focus, expressive
language began emerging
●
Yeast remained a chronic concern and needed ongoing treatment as other interventions were
tried
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IV chelation with CaEDTA, DMPS, NAC and GSH brought more language
●
IVIG added to treatment, helped overall symptoms
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HBOT fueled belief that child will recover, and led to imaginary play and more presence
●
Genomic panel refined treatment approach
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Daniel now in mainstream classroom, indistinguishable from peers. Independent. Very social.
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4 months later
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79
Remember to stop and smell the roses!!!!
#SHEICON2016
Thank You!! #SHEICON2016