the pdf file - Projet BALSAC

Transcription

Dépôt légal : 4e trimestre 2014
Bibliothèque nationale du Canada
Bibliothèque nationale du Québec
ISBN : 2-920803-45-X
2013-2014
Annual Report
Table of contents
3
Word from the director
5
Development Activities
10
Valorization and Operating
Activities
14
Access to Data and Protection
of Privacy
15
Ongoing Research Projects
20
List of Dissemination Activities
24
The BALSAC Project
Word from the Director
I am pleased to present an overview of the work accomplished at BALSAC
this past year to enrich, exploit and enhance the database. But first of all,
on behalf of the entire team, allow me to express our gratitude for the
contributions of all those who make it possible for BALSAC to continue to
grow after more than 40 years.
We first wish to thank the Ministère de l’Économie, de l’Innovation et des
Exportations (MDEIE) for their financial assistance. Their three-year
grant (2011-2014) has enabled us to implement a number of measures
aimed at maintaining our expertise, developing new ways to exploit and
promote the database, and concretely improving the services we offer to
researchers. BALSAC is at the cutting edge of current technology thanks
to support from the MDEIE.
BALSAC and its partners greatly benefited from the leverage created by
that funding. Work on the integrated infrastructure of historical
microdata on the Quebec population (Infrastructure intégrée de
microdonnées historiques de la population du Québec, or IMPQ) is
ongoing thanks to financial support from the Canadian Foundation for
Innovation (CFI) and the Ministère de l’Enseignement supérieur, de la
Recherche et de la Science and to a partnership with the Université de
Montréal and the Université du Québec à Trois-Rivières. This important
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project promises a bright future for the BALSAC Project and the study of
the Quebec population through historical microdata.
In November 2013, BALSAC joined in an application to maintain the
Network of Applied Medical Genetics (RMGA) under the theme network
research funding program managed by the Fonds de recherche du
Québec en santé (FRQS). The funding obtained for 2014-2018 will allow
us to extend our services to more genetics researchers, including those
working with data from the CARTaGENE Project.
It is also important to note the support we receive from the Foundation
and the Programme d’aide à la recherche of the Université du Québec à
Chicoutimi and our three other partner universities (Laval, Montréal and
McGill). Every year, the assistance provided by these institutions proves
crucial to the continued operation and proper management of the
BALSAC Project, which also greatly benefits from the work of an
interinstitutional steering committee, where I am joined by Bernard Brais
from McGill University, Damian Labuda from Université de Montréal
and Marc St-Hilaire from Université Laval. I thank them sincerely for the
time they spent discussing and reflecting on future development
priorities for BALSAC. We are honored to count them among our
ambassadors.
Finally, I want to emphasize the enthusiasm and professionalism of the
entire BALSAC team. We all join in thanking and wishing a happy
retirement to Mario Bourque, who left us this year for a well-deserved
retirement.
Page 5
Development Activities
B u i l d in g t h e I M P Q
BALSAC in Numbers
To date, over 3 million vital records have
been digitized. This includes all Catholic
marriages (and some records from other
denominations) in the province of Quebec
from 1621 to 1965. For the Saguenay-LacSaint-Jean region, the database includes
birth and death records as well as
marriage records from 1838 to 1971. As to
family reconstruction using the data, all
records in the database have been
processed and only the more complex
cases remain to be matched. This year,
over 30 750 linkages were made, with
50 000 more still to come before all records
up to 1965 have been processed
In the 2012 Leading Edge Fund Competition of the Canadian
Foundation for Innovation (CFI), BALSAC and its partners, the
Programme de recherche en démographie historique (PRDH) at the
Université de Montréal and the Centre interuniversitaire d’études
québécoises (CIEQ) at the Université de Trois-Rivières, received major
funding to create the integrated infrastructure of historical microdata
on the Quebec population (IMPQ). The IMPQ will regroup in one
database all available serial microdata on the Quebec population
since the early days of European settlement, namely vital records and
nominal data from the Canadian census. This will position the institution
among leading research entities at the international level and enable
us to preserve, develop and promote a unique scientific and historical
resource to better understand the Quebec population.
For BALSAC, the IMPQ project includes the development of a linkage
software to associate at the nominal level the households from the
census to the families reconstructed in the BALSAC database.
Development of the software was completed in 2013. In the past year,
a linkage function was added to optimize how households with more
than one family nucleus are handled. This feature resolves issues
encountered when matching members of households with more than
one nucleus (for example, a widowed father living with his son's family).
In parallel, the IT team rebuilt an application to explore census records
and created new code to import and manage data. We now have
new space dedicated to census data in the database's relational
structure to handle relationships between BALSAC records and Census
records. A private and secured data sharing network (www.risq.qc.ca)
was also established amongst partner institutions. The physical
installation and configuration of the infrastructure was completed in the
last few months and the network should be functional by October 2014.
To date, households from seven nominal censuses (1852-1911) in TroisRivières and the Côte-Nord region were matched to families from the
BALSAC database (linking census and vital records). The same
matching process was conducted for two censuses from Saguenay
(1871, 1881) and four from Québec City (1851, 1871, 1881 and 1891).
Depending on the census, the linkage software was able to process 80
to 95% of households, the remainder being structured in ways that
prevent linkages with vital records. As we can see in Table 1, the
proportion of matched household also varies depending on the time or
region, but the success rate is over 75% in almost all cases, reaching as
high as 98% in Saguenay. In that region, the BALSAC database includes
birth and death records, which explains the increased performance.
This is also evident in the proportion of census individuals linked to
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BALSAC families, which as can be seen in Table 2 is between 55% and
78% for Trois-Rivières, Côte-Nord and Québec City and jumps to 94% for
Saguenay.
On top of linking census households with the families reconstituted from
vital records, the software has a module enabling it to link different
censuses together (Census-Census + 10 years linkage). The first
intercensus matches were conducted for the regions of Côte-Nord,
Saguenay and Trois-Rivières; the results are presented in Table 3. Here
also, the success rate varies with time and region, but results from TroisRivières and Saguenay show that we can link 60 to 70% of households
recorded in two successive censuses. This past year, the IMPQ project
was presented at the International Union for the Scientific Study of
Population Conference in Korea, at the meeting of the Association des
démographes du Québec during the ACFAS conference, and during a
seminar on computational methods for survey and census data in the
social sciences organized by the Centre de recherches mathématiques
de Montréal. Those presentations demonstrated the richness of the
data that will be available to researchers once the IMPQ is completed.
Efficient and Quick Linkages
The linkage software can associate on a nominative basis census
households to the families from the BALSAC database. A query will return
candidate families to match individuals from a household to their vital
records... in less than three minutes on average!
The Équipe de recherche sur les
populations du passé (ERPP)
met in May 2014 in Québec City for a
workshop on the progress of the IMPQ
project
From left to right, top to bottom :
Philippe Antaya (UQTR), Claude
Bellavance (UQTR), Jean-Sébastien
Bournival (BALSAC),
Marc Tremblay (UQAC),
Eve-Marie Lavoie (BALSAC), Danielle
Gauvreau (Concordia), Lisa Dillon (UdeM),
Alain Gagnon (UdeM), Hélène Vézina
(BALSAC), Laurent Richard (ULaval),
Bertrand Desjardins (UdeM), Michèle
Jomphe (BALSAC), Marc St-Hilaire (ULaval),
Tomy Grenier (UQTR), Marilyn Amore-Vieta
(UdeM) et France Normand (UQTR).
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Table 1 | Ratio of Linked Households to Processed Households
1851
1861
1871
1881
1891
1901
1911
Trois-Rivières
86,1%
81,5%
82,7%
88,9%
92,2%
87,1%
89,9%
Côte-Nord
41,0%
68,0%
84,8%
76,8%
79,5%
78,4%
88,9%
Québec
73,1%
72,9%
79,9%
87,3%
97,9%
98,4%
Saguenay
Table 2 | Ratio of Census Individuals Matched to BALSAC
in Linked Households
1851
1861
1871
1881
1891
1901
1911
Trois-Rivières
63,2%
59,3%
66,0%
65,9%
70,9%
71,3%
73,1%
Côte-Nord
55,8%
58,1%
70,3%
71,9%
74,3%
74,2%
77,5%
Québec
59,4%
63,4%
67,9%
68,1%
93,1%
93,9%
Saguenay
Table 3 | Results from Intercensus Linking Process
Trois-Rivières
Saguenay
Côte-Nord
1852>1861
1891>1901
1871>1881
1861>1871
N
%
N
%
N
%
N
%
Processed
Households
754
95,8
1634
96,1
1875
94,0
719
94,9
Linked
Households
441
58,5
981
60,0
1333
71,1
293
40,1
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C o n t in u in g D e ve l o p m e n t wi t h S u p p o r t f ro m t h e
MDEIE
Originally, the system used to reconstruct families in BALSAC data was
developed exclusively to handle vital records, specifically marriage
records. In order to integrate other types of records like common law
unions, the first imperative was to update the different tables
(dictionaries) to optimize our chances of success when reconstructing
families.
Professions
BALSAC started a project to standardise professions using an
international classification scheme (HISCO/HISCLASS) developed by a
history research group from the Netherlands. This system, a golden
standard in the social sciences, will make the data available to the
international scientific community, allowing for broader comparative
analysis. This year, some 44 000 occupations were standardized, or 97%
of all occupations recorded in BALSAC. The remaining 3% are
occupations that only occur once, are ambiguous or erroneous. The
operation will allow to assign a code to most occupations listed in the
census. A document describing the project and coding process as well
as statistics on occupations will be added to the BALSAC bibliography in
the fall 2014.
Names and Surnames
The many rounds of expansion in the last years have increased the size
and diversity of the BALSAC names and surnames dictionaries, which
are core to the family reconstruction system. It became necessary to
revise the standards and the rules of the phonetic code, which were
originally created for a predominantly francophone patronymic pool
limited to the Saguenay region. A full revision was completed in the
spring of 2014. This operation included the correction and
standardization of spellings to improve matching rates by removing
extra characters like hyphens, periods and apostrophes, for example.
The 579 000 male and female names found to be similar were grouped,
placing all variants of one name under one code. This helped eliminate
doubles and clean up the tables to receive new variants and foreign
names from census data and the RETRO genealogical module. In the
end, the BALSAC name dictionary now includes almost 230 000 distinct
surnames and all their variants observed in the vital records, and the first
name dictionary counts almost 450 000 distinct names and their variant
spellings. This large-scale operation will greatly improve the
effectiveness of the linking process, which is based mainly on the
comparison of nominative elements.
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Résidence Outside Quebec
Important both in its scope and significance, the residence tables
update began in spring 2014. Using official geographical names
databases, BALSAC created a dictionary to classify residence and
follow data entry by recording location. This dictionary includes all
places of residence mentioned in vital records, which can be grouped
at different levels (country, region, census district, residential unit, town,
village, parish, etc.) Places outside the province of Quebec (particularly
in France and the United States) were also included in the dictionary,
but their classification was less systematic and required a major update.
All information on French or American residence was originally entered
in one field, so it was extremely difficult to sort cities from states or from
departments. Funding from the MDEIE was used to split and optimize
the data, and we are now able to conduct analysis at different
geographical levels (from city to country). This will be supplemented
with longitude and latitude coordinates for all residential units in
Quebec. The foundation dates of Catholic parishes were also
validated. The residence dictionary update will be complete in the fall
of 2014. The dictionary now includes over 12 000 entries plus all their
variants from the vital records, for a total of 22 600 places of residence.
Integration of Events Other than Vital Records
The active participation of BALSAC in the CARTaGENE Project brought
to the fore the need for some software changes to facilitate the
addition of genealogical data from contemporary individuals. In order
to handle portions of genealogies not covered in BALSAC, the RETRO
genealogical database was developed in parallel to store data from
sources other than vital records. Once we finish importing RETRO data
into BALSAC, researchers interested in genealogies will be able to use
our specialized tools on more data without being hampered by the
gaps between separate databases and the limitations of the software.
Thus the scientific community will directly benefit from this integration.
The integration of RETRO into BALSAC began with the complete revision
of the two databases’ relational schemes. Then, two important
applications were upgraded: Bal-Saisie, used to enter new events into
the database and modify existing records, and CARGO, used to
reconstruct genealogical lineages. The operation required several
rounds of testing to confirm data compatibility and the standardization
of certain variables, always with the objective to improve data entry
and linkages. Finally, integration and coherence queries were
developed to assure the integrity of both databases is maintained. To
date, many trials were conducted in testing environments and the final
integration is scheduled for late fall 2014.
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Valorization and Operating Activities
Outreach and awareness have a direct impact on the use of BALSAC
data by researchers. Efforts to valorize and fully exploit the database
are therefore at the heart of our strategy to reach and recruit new users
and maintain the many relationships we already have within the
national and international scientific community. It is in this perspective
that we undertake the following activities to showcase the data and
analysis tools in their best light. This continued effort has thus far greatly
improved the Project’s recognition and reputation in the fields of history
and the social sciences, but also population genetics and the
biomedical sciences.
Service for researchers
BALSAC provides assistance to
researchers wishing to access
BALSAC data.
Michèle Jomphe
balsac@uqac.ca
E xp l o i t i n g t h e Da t a
Communications and publications by users/researchers are our main
avenue to promote the project. The full list of publications for 2013-2014
can be found in another section.
The main indicator of the Project's performance is the total number of
researchers who use the infrastructure. This has a direct impact on the
number of publications using the data, and informs us on the
researchers’ affiliations, fields and areas of research. In the last year,
data from BALSAC was used in 42 projects involving 48 researchers and
almost 60 students, assistants and research professionals.
Users’ Affiliations :
Furthermore, as per its mandate as part of the Network of Applied
Medical Genetics research infrastructure, BALSAC provides researchers
with access to anonymized genealogical data that can be combined
to genetic data from the laboratory of Damian Labuda at the Research
Centre of CHU Ste-Justine. This data is available on the Quebec
Reference Sample - Population Genetics and Genetic Epidemiology in
Quebec website at this address: http://www.quebecgenpop.ca/
418-545-5011 poste 6539
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The full list of research projects undertaken in 2013-2014 can be found
on page 15.
Research Areas
Genetic Epidemiology
15
Demogenetic and
biodemography
14
Social Sciences
11
Methodological
Developments
6
46 projets
C o o r d in a t i n g A c ce s s t o t h e G e n e a lo g i e s o f
C A R T a G E N E P r o je c t P a rt i c i p a n t s
BALSAC is coordinating the genealogical component of the second
phase of the CARTaGENE Project. This involves getting informed consent
from participants and managing, collecting and compiling the results of
a genealogical questionnaire.
The development of an electronic genealogical questionnaire and
management application was finalized in the fall of 2012. The first
questionnaires were sent out to participants in January 2013. In total,
between September 2013 and August 2014, 11 000 people were invited
to participate in the genealogical option.
The information collected from the participants will be used to
reconstitute genealogical lineages that can then be used for research
in conjunction with other data on health and life habits collected by
CARTaGENE.
C r e a t in g a D e m o - G e n e t ic P o r t ra i t o f t h e
Q u e b e c P o p u la t io n
Supported by the Réseau de médecine génétique appliquée of the
FRQS among others, the objective of this activity is to promote the
BALSAC Project to the scientific community and illustrate all its potential
in order to attract more researchers. It is a way to produce original
scientific data and make it available for research purposes. Popular
science publications are also created from those studies to give a
broader audience some of the insights derived from the data. Finally,
this exercise allows us test the robustness of our analysis tools, notably
GENLIB, when handling large volumes of data.
Painting a demo-genetic portrait of the Quebec population using
BALSAC population data was an interesting initiative. As an illustration,
the genealogies of over 25 000 individuals from all corners of the
province were reconstructed and measured in different ways. This is the
first genealogical sample of that magnitude and generational depth for
the Quebec population. Findings were presented at scientific
conferences and French and English capsules "Did you know?"
summaries
will
be
posted
to
the
BALSAC
website
(http://balsac.uqac.ca). This year, we explored the following themes:
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Consanguinity in the
Regional Populations
of Quebec
Using 46,451 genealogies to measure
variations in the level of close consanguinity
at different periods in regional populations
in Quebec.
Effective Offspring
Number in Different
Periods
Measuring time and location variations of
effective offspring number for 735 457
individuals married between 1640 and 1910.
Contributions of the King’s
Daughters to the Quebec
Population
Development of strategies to identify King's
Daughters in the BALSAC data and measure
their contribution to the contemporary
population.
The following capsules « Did you know ? » were published on the
BALSAC website :
… The founders of the French-Canadian population do not all originate
from France? (in French)
…Some ancestors appear in the genealogies of almost all Quebecois of
Frech Canadian ancestry? (in French)
...Super-ancestors in the genealogy of French Canadians who stand out
for their large number of occurrences in the same genealogy?
…Surnames tell a story?
Finally, the analyses conducted for this activity will be published in a
special issue of the magazine Saguenayensia in winter 2015.
R e a ch i n g a W id e r P u b l i c
Many of our outreach activities address the greater public and the
media. The team is always willing to initiate young people to social
science research or demonstrate to genealogists the large-scale studies
made possible by our population database, for example. You will recall
the permanent exhibit "Des racines et des rêves : un regard sur le
Saguenay-Lac-Saint-Jean" inaugurated in 2012. The show presents the
history of the region and its inhabitants in a scientific light supported by
40 years of research using BALSAC data. Since it opened, the exhibit
was seen by over 64 000 visitors at the Musée du Fjord, who had a
chance to discover BALSAC and the work of our researchers. The
awards and recognition heaped on the Musée are evidence of the
quality of the exhibit and the interest of the public.
-
Mention honorable de l’Association des musées canadiens;
-
Lauréat Bronze dans la catégorie Attraction touristique 25 000 à 100 000 visiteurs;
-
Gala régional des Grands prix du tourisme 2013, Attractions
touristiques - 25 000 à 100 000 visiteurs;
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-
Prix Coup d’Éclat 2012. Remis par la Société des Attractions
touristiques du Québec;
-
Bourse Québecor Média d’une valeur de 43 500$.
In October 2013, this list got a bit longer with the addition of the
Excellence Award for the permanent exhibit renewal project from the
Société des musées québécois. The partnership continues to be fruitful,
as the Musée du Fjord recently participated in the popular television
series on genealogy Qui-êtes-vous? to be broadcast by Radio-Canada
in 2014-2015.
M a i n t a i n in g a D i ve r s e N e t wo r k
In order to ensure the visibility of the project and improve the services
offered to the scientific community, BALSAC is involved in several
national and international collaborations.
 With Social Sciences and History Research Teams
Centre interuniversitaire d’études québécoises (CIEQ) Group of
researchers from nine universities who study how Quebec society has
transformed since the first settlements.
Research Program in Historical Demography (PRDH) The Quebec
population register contains 700,000 records (baptism, marriage and
death certificates) from the early days of the colony to the end of the
18th century, with additional data from the Canadian census from the
19th century.
EurAmerica Group of European and North American researchers who
utilize available data from the 19th and 20th centuries to understand
and compare the evolution of various demographic phenomena.
European Historical Population Samples Network (EHPS-Net) Group
working to create a common format to provide access and enable
comparisons between different databases containing information on
individuals, families and households.
Collaboratory on Historical International Standard Classification of
Occupations (HISCO) International framework for the classification of
occupations for the purpose of historical research.
 With Basic Science Research Teams
CARTaGENE Both a specific public health survey and a resource for
researchers interested in genomes, epidemiology, genetics or public
health, CARTaGENE maintains a database and representative samples
of the genomic diversity of over 20,000 Quebecers, of which 5400 are
available for genealogical analysis.
Montreal Spring School of Population Genomics and Genetic
Epidemiology Over the last 6 years, the BALSAC database and relevant
analysis tools are presented in an annual workshop open to the
scientific community.
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 With Community Associations
Corporation de recherche et d’action sur les maladies héréditaires
(CORAMH) Non-profit organisation working to prevent hereditary
diseases in Saguenay-Lac-St-Jean through awareness, information and
education.
Regroupement québécois des maladies orphelines (RQMO) RQMO is a
group of associations whose members or their family are suffering from
rare diseases. Its mandate is to further knowledge on rare diseases,
facilitate contact between caregivers and patients and raise
awareness.
Access to Data
and Protection of Privacy
The BALSAC Project's partner institutions have given to the Université du
Québec à Chicoutimi the responsibility to manage access to the
database and protect the confidentiality of the personal information it
contains.
R e p o r t f ro m t h e Co m m it t e e
f o r t h e P ro t e c t io n o f P r i va c y
a n d A c c e s s t o Da t a
For this purpose, the UQAC Board of Directors has entrusted the
application of the Policy on Access to BALSAC Data for Research
Purposes to the Committee for the Protection of Privacy and Access
to Data (CPAD) and the BALSAC Project directors. The CPAD is the
entity charged with evaluating requests for access to confidential
data for research purposes. It is composed of five members:
•
Marc Tremblay, Professor, Human Sciences, UQAC;
•
Jacinthe Douesnard, Professor, Economic and Administrative
Sciences, UQAC;
•
François Guérard, Professor, Human sciences, UQAC;
•
Christine Drolet, Communications Consultant, Chicoutimi Health
and Social Services Centre;
•
Michèle Jomphe, Research Professional, BALSAC Project.
This section of the BALSAC Annual Report serves as a summary of the
CPAD's activities for the UQAC Board of Directors. In 2013-2014, no new
request was made to access confidential BALSAC data. The committee
was however consulted on the delays affecting requests for access
submitted to the Commission d’accès à l’information du Québec under
article 125 of the Act respecting Access to documents held by public
bodies and the Protection of personal information, as well as on the
possibility to use BALSAC data for clinical purposes. Under the terms of
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the Policy, the detailed list of ongoing research projects can be found
on page 15.
R e p o r t f ro m t h e B A L S A C S t e e r in g C o m m it t e e
The Steering Committee is mandated by the UQAC Board of Directors
to evaluate all requests for access to non-confidential BALSAC data.
The committee includes Hélène Vézina, Mario Bourque, Ève-Marie
Lavoie and Michèle Jomphe. Jean-Sébastien Bournival provides
assistance managing data access forms and agreements and Jacinthe
Sabourin handles the keys. In 2013-2014, the committee was consulted
approximately twenty times on data access or privacy matters. Four (4)
requests for access to non-confidential data and four (4) requests for
extensions of access to data were submitted to the Committee.
Ongoing Research Projects
G e n e t ic E p i d e m i o lo g y
Analyse et caractérisation des effets fondateurs pour les mutations responsables
des maladies de Morquio et de Tay-Sachs chez les Canadiens français.
VÉZINA Hélène
Université du Québec à Chicoutimi
OUELLETTE Gail
Portail québécois des maladies orphelines
Étude de la prédisposition génétique à la sclérose en plaques au Québec
ST-HILAIRE Marc
Institut et Hôpital neurologiques de Montréal
Université McGill
Université Laval
DUBÉ Marie-Pierre
Université de Montréal
BRAIS Bernard
Étude démographique et généalogique de la névrite optique héréditaire de Leber
DESJARDINS Bertrand
Université McGill
TREMBLAY Marc
BRAIS Bernard
ST-HILAIRE Marc
Université Laval
VÉZINA Hélène
Caractérisation génétique des ataxies spino-cérébelleuses héréditaires :
volet généalogique
BRAIS Bernard
Centre de recherche CHUM Notre-Dame
ST-HILAIRE Marc
Université Laval
DESJARDINS Bertrand
TREMBLAY Marc
VÉZINA Hélène
Étude généalogique de la dystrophie musculaire oculopharyngée
DESJARDINS Bertrand
Université McGill
VÉZINA Hélène
BRAIS Bernard
ST-HILAIRE Marc
Université Laval
TREMBLAY Marc
Page 16
Étude de l'introduction des mutations de la névrite héréditaire sensitive
et autonomique de type 2 (NHSA2) au Québec et des modifications sensitives
chez les porteurs hétérozygotes
BRAIS Bernard
ST-HILAIRE Marc
Université McGill
Université Laval
VÉZINA Hélène
TREMBLAY Marc
Recherche des gènes de l’hypertension et de ses facteurs associés
HAMET Pavel
CHUM Hôtel-Dieu
SEDOVA Lucie
CHUM Technopole Angus
GAUDET Daniel
CSSS-Chicoutimi
BOUCHARD Gérard
DUMAS Pierre
MERLO Ettore
École polytechnique Université de Montréal
SEDA Ondrej
Étude des déterminants génétiques de l'asthme au Saguenay-Lac-St-Jean
LAPRISE Catherine
VÉZINA Hélène
LABUDA Damian
ROY-GAGNON Marie-Hélène
CHU-Ste Justine
Nature polygénique du glaucome à angle ouvert
RAYMOND Vincent
Université Laval
Recherche des déterminants génétiques de la mucolipidose de type II
dans la région du Saguenay-Lac-St-Jean
VÉZINA Hélène
LAPRISE Catherine
Analyse des effets associés aux transmissions maternelle et paternelle de
l'hypercholestérolémie familiale et des déterminants démogénétiques
de la distribution des diverses mutations et de l'intolérance aux statines
COUTURE Patrick
Université Laval
GAUDET Daniel
CSSS-Chicoutimi
BRISSON Diane
CSSS-Chicoutimi
TREMBLAY Marc
Malformations cardiaques congénitales: vers une analyse génomique intégrale
ANDELFINGER Gregor U.
Cardiologue CHU-Ste Justine
DUBÉ Marie-Pierre
Étude rétrospective des paramètres cliniques et paracliniques des patients
affectés par des tumeurs sécrétrices de catécholamines au CHUM
(paragangliome phéochromocytome et ganglioneurome surrénaliens)
BOURDEAU Isabelle
CRCHUM-Hôtel-Dieu
GRUNENWALD Solange
CRCHUM-Hôtel-Dieu
VÉZINA Hélène
BINET Marie-Claire
Médecine génique CHUM
Effet fondateur dans la population canadienne-française avec le syndrome AMRF
ANDERMANN Frederick
VÉZINA Hélène
AMROM Dina
ANDERMANN Eva
Institut et hôpital neurologique de Montréal
Université McGill
Université McGill
Université McGill
Vers une utilisation optimale des ressources généalogiques de la population
québécoise en épidémiologie génétique
CHU-Ste Justine
Page 17
LABUDA Damian
VÉZINA Hélène
D e m o g e n e t ic
Influence de divers facteurs démographiques sur la fécondité des femmes
Projet terminé en 2013-2014
LUMMAA Virpi
Sheffield University, Angleterre
Caractéristiques démogénétiques des populations régionales du Québec
TREMBLAY Marc
VÉZINA Hélène
DESJARDINS Bertrand
CHU-Ste Justine
Ramifications génétiques et démographiques de l'effet fondateur québécois
Prolongation accordée en 2013-2014
BHÉRER Claude
Study of genetic predisposition to fertility and longevity and of their possible
relationship in the BALSAC population
PEARSON Peter Lees
Université de Sao Paulo, Brésil
OTTO Alberto Otto
Université de Sao Paulo, Brésil
Portrait démogénétique de la population du Québec
Demande de prolongation en cours
VÉZINA Hélène
TREMBLAY Marc
Diversité, relations interculturelles et intégration: une étude sociodémographique
et démogénétique de la population du Québec, 1760-1940
VÉZINA Hélène
GAUVREAU Danielle
Université Concordia
OLSON Sherry
Université McGill
THORNTON Patricia
Analyse des caractéristique généalogiques des participants au projet CARTaGENE
TREMBLAY Marc
Étude du phénomène de surf génétique dans la population de Charlevoix
et du Saguenay Lac-St-Jean
LABUDA Damian
VÉZINA Hélène
EXCOFFIER Laurent
Université de Bern, Suisse
Groupe de référence en épidémiologie génétique et génétique
des populations humaines au Québec
VÉZINA Hélène
LABUDA Damian
TREMBLAY Marc
CHU-Ste Justine
EXCOFFIER Laurent
Université de Bern, Suisse
Fecundity and human evolution
GALOR Oded
Université Brown, États-Unis
KLEMP Marc
Page 18
Test de l’accumulation de mutations délétères lors d’expansions spatiales
par le séquençage d’exomes
EXCOFFIER Laurent
Université de Berne, Suisse
DUPERRET Isabelle
FOUCAL Adrien
La consanguinité au Québec : description spatiale et temporelle du phénomène
en utilisant le fichier de population BALSAC
ASSELIN Tommy
Hérédité et mortalité
CHARPENTIER Arthur
Université du Québec à Montréal
VIARD Julie
Université de Rennes, France
La contribution démographique et génétique des Filles du Roy
à la population québécoise contemporaine
Nouveau projet 2013-2014
DESPORTES Sophie
S o c ia l S c i e n c e s
Occupation de l'espace au Québec
ST-HILAIRE Marc
Université Laval
Espace social et urbanisation : dynamique spatiale
de l'espace métropolitain de Québec, 1851-1961
LANOUETTE Nicolas
Université du Québec à Trois-Rivières
Appariement d'un échantillon des données du recensement canadien 1871
au recensement de 1881
DILLON Lisa
Pont de glace, inondation et navigation. Aménagement et gestion
du fleuve Saint-Laurent dans la seconde moitié du XIXe siècle
ANTAYA François
Étude socio-historique de l'apparentement des médecins
du Québec du régime français à la deuxième guerre mondiale
BRAIS Bernard
GOULET Denis
Institut et Hôpital neurologiques de Montréal,
Université McGill
Historical International Social Mobility Analysis (HISMA): international comparison
of mobility patterns during the 19th and 20th century
MAAS Ineke
Université d’Utrecht, Pays-Bas
VAN LEEUWEN Marco
Université d’Utrecht, Pays-Bas
VÉZINA Hélène
EurAmerica: Comparative research on the micro demography
of 20th century Europe and America
VÉZINA Hélène
GAGNON Alain
GAUVREAU Danielle
Mesure des effets réciproques de la longévité et de la fécondité
GAGNON Alain
L’influence de la fratrie pour l’accès au mariage : étude comparative
Page 19
sur le Québec et la Belgique
CARON Marianne
DILLON Lisa
GAGNON Alain
Center for Sociological Research,
Family and Population, Belgique
Center for Sociological Research,
Family and Population, Belgique
MATTHIS Koenraad
NEYRINCK Ward
DESJARDINS Bertrand
La mobilité sociale intergénérationnelle au Québec et en Ontario
dans la deuxième moitié du 19è siècle
TORRES CANTOR Catalina
Diversity and development
KLEMP Marc
GALOR Oded
M e t h o d o l o g i ca l D e ve l o p m e n t s
Projet d'Infrastructure intégrée de microdonnées historiques de la population
du Québec (1621-1965) (IMPQ)
VÉZINA Hélène
TREMBLAY Marc
LABUDA Damian
DILLON Lisa
GAGNON Alain
DESJARDINS Bertrand
GAUVREAU Danielle
ST-HILAIRE Marc
Université Laval
MARCOUX Richard
Université Laval
BELLAVANCE Claude
NORMAND France
Développement d’un prototype de jumelage assisté par ordinateur
permettant d’associer les ménages des recensements aux familles reconstituées
du fichier BALSAC
ST-HILAIRE Marc
Université Laval
VÉZINA Hélène
Jonction des fichiers RPQA et BALSAC
DESJARDINS Bertrand
Modèles généalogiques spatio-temporels
BOUCHARD-CÔTÉ Alexandre
Université de Colombie Britannique
KIRKPATRICK Bonnie
Université de Colombie Britannique
Opérations préliminaires de jumelage du fichier BALSAC avec
le Registre de population du Québec ancien (RPQA) en vue
de la création d'une base de données intégrée
DESJARDINS Bertrand
Page 20
Tests sur un fichier en format "épisodes" en vue
d'analyses statistiques et de conversion
BOURNIVAL Jean-Sébastien
List of Disseminartion Activities
Articles
Gauvin, H., Moreau, C., Lefebvre, J.-F., Laprise, C., Vézina, H., Labuda,
D., & Roy-Gagnon, M.-H. (2014). Genome-wide patterns of identity-bydescent sharing in the French Canadian founder population. European
Journal of Human Genetics, 22, 814–821. doi :10.1038/ejhg.2013.227
St-Hilaire, M., Richard, L., & Marcoux, R. (2014). Individual and familial life
courses in Quebec City, 1871-1911: Some considerations on two
biographical data-sets. Dans The dawn of Canada’s century: hidden
histories (pp. 322–358). Montreal : McGill-Queen’s University Press.
Tremblay, M. (2014). Les origines régionales ancestrales au Québec.
Cahiers
québécois
de
démographie,
43(1),
133-161.
doi:10.7202/1025493ar
Tremblay, M., Bouhali, T., Gaudet, D., & Brisson, D. (2014). Genealogical
analysis as a new approach for the investigation of drug intolerance
heritability. European Journal of Human Genetics, 22(7), 916–922.
doi:10.1038/ejhg.2013.270
Vézina, H., Gauvreau, D., & Gagnon, A. (2014). Socioeconomic fertility
differentials in a late transition setting: A micro-level analysis of the
Saguenay region in Quebec. Demographic Research, 30(38), 1098–
1027. doi:10.4054/DemRes.2014.30.38
Vézina, H., Tremblay, M., Lavoie, È.-M., & Labuda, D. (2014).
Concordance entre origine ethnique déclarée et origines ancestrales
chez
les
Gaspésiens.
Population,
69(1),
7-28.
doi:10.3917/popu.1401.0007
C o m m u n i ca t io n s
Bherer, C., Excoffier, L., Roy-Gagnon, M.-H., Hussin, J., Vézina, H., &
Labuda, D. (2013). Genealogical evidence of allele frequency shuffling
explains regional genetic structure in a founder population. Dans
American Society of Human Genetics Conference. Boston. 22-26
octobre.
Caron, M. (2014). Une histoire de famille? Le choix du conjoint au
Québec du 18e et 19e siècle. Dans Association internationale des
démographes de langue française. Bari, Italie. 26-29 mai.
Page 21
Caron, M., & Neyrinck, W. (2014). The influence of siblings for access to
marriage: a comparative study on Quebec and Belgium, 1842-1912.
Dans European Social Science History Conference. Vienne, Autriche. 25
avril.
Dribe, M., Bras, H., Breschi, M., & Gagnon. (2013). Socioeconomic status
and fertility: Insights from historical transitions in Europe and North
America. Dans Presentation at the Economic History Association 2013
Annual Meeting. Washington. 20 -22 septembre.
Ghislain, C., & St-Hilaire, M. (2013). Microdonnées et renouvellement des
études rétrospectives de population: l’exemple canadien à partir des
recensements des XIXe et XXe siècles. Dans Chaire Quetelet. Louvainla-Neuve, France. 14 novembre.
Milot, E. (2014). Malédiction maternelle et maladies mitochondriales: le
cas de la neuropathie optique de Leber. Dans Journées génétiques du
RMGA. Montréal. 15 mai.
Moreau, C. (2014). Deep rooted human genealogies and their use in
genetic epidemiology. Dans Montreal Spring School of Population
Genomics and Genetic Epidemiology. Mai.
Moreau, C., Milot, E., Preuss, C., Vézina, H., Roy-Gagnon, M.-H.,
Andelfinger, G., & Labuda, D. (2014). Identification du locus associé au
syndrome de CAID et du couple l’ayant introduit en Nouvelle-France.
Dans Journées génétiques du RMGA. Montréal. 14-16 mai.
Moreau, C., Lefebvre, J.-F., Gauvin, H., Jomphe, M., Preuss, C.,
Andelfinger, G., Labuda, D., Vézina, H. & Roy-Gagnon, M.-H. (2014).
Identifying founders most likely to have introduced disease-causing
mutations with the R package GenLib. Dans International Genetic
Epidemiology Society. Vienne, Autriche. Août.
Roy-Gagnon, M.-H. (2013). Empirical kinship estimation in the French
Canadian founder population. Dans Department of Epidemiology and
Biostatistics. Montréal. Octobre.
St-Hilaire, M. (2014). SIGH et données spatio-temporelles au CIEQ. Dans
Participation à l’atelier-conférence canadien sur les SIG historiques à
l'UQAM. Montréal. 31 janvier.
Tremblay, M. (2014). Analyse des caractéristiques généalogiques des
participants au projet CARTaGENE. Dans Colloque La démographie de
demain: innovations, intersections et collaborations, 82e congrès
annuel de l’ACFAS. Montréal. 12-16 mai.
Vézina, H., & Brunet, G. (2013). Les approches intergénérationnelles en
démographie historique. Dans Colloque organisé à l’occasion du 50e
anniversaire de la Société de démographie historique. Paris France. 5-6
septembre.
Page 22
Vézina, H. (2013). Aspects démogénétiques de la santé. Dans
Programme de DESS en Éco-conseil, Université du Québec à
Chicoutimi. Chicoutimi (Québec), Canada. 24 octobre.
Vézina, H. (2013). Génétique et population: le fichier BALSAC, une
ressource unique pour mieux comprendre les maladies héréditaires au
Québec. Dans Table ronde des Instituts de recherche en santé du
Canada: Vers une approche concertée de prise en charge des
maladies héréditaires orphelines. Saguenay. 19 novembre.
Vézina, H. (2013). Genealogical investigation of the genetic heritage of
the French Canadian population. Dans Population Genetics Lab,
Institute of Ecology and Evolution, Université de Berne. Suisse. 28
novembre.
Vézina, H., & Lavoie, È.-M. (2013). Métissage entre les Autochtones et les
Canadiens français au Québec: que nous apprennent les actes de
mariage? Dans Vingt-sixièmes Entretiens du Centre Jacques Cartier,
Colloque Populations pionnières, populations coloniales, populations
métisses (Afrique et Amériques, XVIe-XXe siècles). Lyon (France). 25-26
novembre.
Vézina, H., St-Hilaire, M., & Bellavance, C. (2014). Le jumelage des
données d’état civil et de recensement pour le développement de
l'Infrastructure intégrée des microdonnées historiques de la population
québécoise
(IMPQ).
Dans
Colloque
La
démographie
de
demain: innovations, intersections et collaborations. 82e congrès
annuel de l’ACFAS. Montréal. 12-16 mai.
Vézina, H. (2014). Positionnement et rayonnement international d’une
infrastructure de recherche sur la population québécoise. Dans Tableronde Le Québec dans le monde: réseaux, influences, contributions.
Colloque 20e anniversaire du CIEQ. Québec. Juin.
Vézina, H. (2014). The linkage of micro census data to vital records: new
perspectives for population reconstruction. Dans « Méthodes de calcul
des données de sondage et de recensement en sciences sociales » Un
atelier pour statisticiens et chercheurs en sciences sociales. Centre de
recherches mathématiques, Montréal. 20-21 juin.
P o st e r
Bherer, C., Excoffier, L., Roy-Gagnon, M.-H., Hussin, J., Vézina, H., &
Labuda, D. (2013). Genealogical evidence of allele frequency shuffling
explains regional genetic structure in a founder population. Dans Poster
presentation Workshop on Coalescent Theory: New developments and
Applications. Centre de recherches mathématiques de l’Université de
Montréal, Montréal. 7- 11 octobre.
Tremblay, M. (2014). The contribution of English, Scottish and German
settlers to the French-Canadian gene pool of the Quebec (Canada)
Page 23
population. Dans Poster session, European Population Conference.
Budapest, Hongrie. 25-28 juin.
B A L S A C D o cu m e n t s
BALSAC (2013). Entente interinstitutionnelle entre l’Université du Québec
à Chicoutimi, l’Université du Québec à Trois-Rivières et l’Université de
Montréal dans le cadre du projet Infrastructure intégrée des
microdonnées historiques de la population du Québec (1621-1965).
Document Balsac-254, p. 27. Chicoutimi (Québec), Canada.
Lavoie, È.-M., & Vézina, H. (2013). Métissage entre les autochtones et les
Canadiens français au Québec: que nous apprennent les actes
de mariages. Document Balsac-264, (p. 12). Chicoutimi (Québec),
Canada.
Tremblay, M., & Desbiens, D. (2013). Fusion de la base de données
BALSAC et RETROCARGO. Journal des travaux : tâches et résolutions.
Tremblay,
M.,
&
Desbiens,
D.
(2013).
Fusion
RETROBALSAC: Documentation, questions et réponses. Document Balsac-259,
p. 21. Chicoutimi (Québec), Canada.
Tremblay, M., & Desbiens, D. (2014). BALSAC Saisie. Processus de
sauvegarde : Baptême, Mariage et Sépulture. Document Balsac-260,
p. 5. Chicoutimi (Québec), Canada.
BALSAC et RETROCARGO. Plan de mise en production et
documentation de référence. Document Balsac-261, p. 7. Chicoutimi
(Québec), Canada.
BALSAC et RETROCARGO. Liste de mise en production et
documentation de référence. Document Balsac-262, p. 3. Chicoutimi
(Québec), Canada.
Tremblay, M., & Desbiens, D. (2014). Architecture réseau Projet FCI. Pont
entre les deux SGBD et MS SQL server. Connexion TCP/IP socket 1433.
Doctoral Thesis
Bherer C. (2014). Ramifications génétiques et démographiques de
l'effet fondateur québécois. Thèse de doctorat, Université de Montréal.
Page 24
The BALSAC Project
Interinstitutional Steering Committee
The BALSAC Project can now count on the advice of an Interinstitutional
Steering Committee to discuss the high-level direction of the project,
guide management on development priorities and support activities to
exploit and valorize the database. These are the members of the ISC:
Bernard Brais is Professor of Human Genetics
at McGill University and neurogeneticist at
the Montreal Neurological Institute.
Damian Labuda is Professor in the
Department of Pediatrics at the Université
de Montréal and researcher at the
Research Center of the CHU Ste-Justine.
Marc St-Hilaire is Professor in the
Department of Geography at Université
Laval and Director of CIEQ Université Laval.
Hélène Vézina is Professor in the Department
of Human Sciences at the Université du
Québec à Chicoutimi and Director of
BALSAC Project.
Organization Chart
Conseil des universités partenaires
UQAC | U. Laval | McGill | UdeM
Comité de protection et
d’accès aux données
Directrice
Projet BALSAC
Comité d’orientation
interinstitutionnel
Comité directeur
Secteur développement
Secteur exploitation et valorisation
Service aux chercheurs
Staff
Manon Bouchard, Jean-Sébastien Bournival, Mario Bourque, Jocelyn
Côté, Dominic Desbiens, Michèle Jomphe, Ève-Marie Lavoie, Carole
Roy, Jacinthe Sabourin, Michaël Tremblay.
Students and research assistants
Sophie Desportes, Gabrielle Rouleau, Sara-Jeanne Lemieux
555 boulevard Université | Chicoutimi (Québec) Canada
G7H 2B1 | 418.545.5517
Email: balsac@uqac.ca
Site Web : http://balsac.uqac.ca

the pdf file - Projet BALSAC

Transcription

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