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M. Lee, P. Lee, A. Lin, M. Nanos, G. Smith, T. Stransky, J. Willdigg
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Department of Biology, Stony Brook University Stony Brook, NY 11794-5140
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Figure 2- Based on data collected by David
S. Jones, et. al. Treatments for infectious
diseases have vastly improved, leaving
chronic illnesses as the largest cause of
health problems today. We decided to
continue Apis-Biotics and create
Nephrotides.
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"GMOs & Biotechnology." FEW Resources.org. N.p., n.d. Web. 22 Sept. 2015.
"Italian Bee." Wikipedia. Wikimedia Foundation, n.d. Web. 21 Sept. 2015.
Save your tem
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Figure 6- Cell microencapsulation puts a barrier between the synthetic cells and the human immune system
but glucose would be able to enter the capsule and the active tripeptide could exit.
Sources "Biblioguide En Thérapie Génique." Ecole Polytechnique Federale De Lausanne. EPFL, n.d. Web. 14
Sept. 2015.
David S. Jones, M.D., Ph.D., Scott H. Podolsky, M.D., and Jeremy A. Greene, M.D.,
Medical School in The Burden of Disease and the Changing Task of Medicine.
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The tripeptide QSP
downregulates the
reabsorption of glucose
via inhibition of SGLT2, a
channel in the proximal
tubule. SGLT2 is
responsible for 90% of all
glucose reuptake. QSP
prevents new channels
from being formed in the
kidneys, leading to an
overall reduction in blood
glucose levels (Kroiss).
Modeling Figure 5: Melittin
Optimus shows
around a 100 fold
increase in
expression over
natural Melittin.
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Figure 1- Diabetes prevalence has spiked in the
last decade with the number of diabetics
increasing over 200 percent.
Figure 3- Our 2 cell circuit to treat type II
diabetes.The blue cell senses blood
osmoregularity through OmpC. In response, a
string of tripeptides is produced and exported
through a modified HlyA secretion pathway.
These inactive proteins will come into contact
with the protease on the membrane of the
green cell, which cleaves the string into active
tripeptides.
The Drug QSP
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Figure 4: Proline
Iminopeptidase and QSP
tripeptide constructions
were BioBricked (Protease
shown in picture).
Ph.D. at Harvard
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Kroiss, Matthais, Marina Leyerer, and Valentin Gorboulev. “Transporter Regulator RS1 (RSC1A1) Coats
the Trans-Golgi Network and Migrates into the Nucleus.” American Journal of Physiology 291.6 (2006):
n. pag. Web. 21 Sept. 2015.
Acknowledgements Dr. Peter Gergen, Undergraduate Biology Department
Dr. Kevin Czaplinski, Department of Biochemistry and Cell Biology
Dr. Jessica Seeliger, Department of Pharmacological Sciences
Dr. Gabor Balazsi, Laufer Center for Physical and Quantitative Biology
Dr. Joshua Rest, Department of Ecology and Evolution
Dr. David Thanassi, Department of Biochemistry and Cell Biology
Dr. Steven Glynn, Department of Biochemistry and Cell Biology
Dr. Matthew Bennett, Department of Biosciences, Rice University
Dr. M Ete Chan, Department of Biomedical Engineering
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