Research Education Programs Handbook
Transcription
Research Education Programs Handbook
Composition and Responsibilities of Methodist Academy Components Methodist Academy The Methodist Academy is the academic branch of The Methodist Hospital Research Institute. It was established to foster partnerships with academic institutions in order to train students and postdoctoral researchers to be leaders in medical translational research. Opportunities exist for study in fields including: Translational Imaging, Nanomedicine, Systems Medicine and Bioengineering, Cancer, Cardiovascular Disease, Diabetes and Metabolic Disease, Infectious Disease, Neurosciences, Inflammation and Epigenetics, Genomic Medicine, Transplantation Biology, and Tissue Engineering and Regenerative Medicine. Methodist Academy Trainee Association The Methodist Academy Trainee Association (MATA) is a self-governed organization of undergraduate students, graduate students, medical students, postdoctoral and clinical research fellows, residents and other individuals in a training capacity involved in research at the Research Institute. MATA has an elected president, two vice presidents (one postdoctoral and one pre-doctoral) and a secretary. These elected officials will have a term of one (1) year in which they will help to organize all MATA related activities. MATA is designed for the trainees of the Research Institute and serves as a centralized organization for education, networking, intramural activities, and career development and advancement opportunities. MATA will host and sponsor events such as seminars, lectures, journal clubs and workshops that are designed to be of interest to the Research Institute trainees. MATA also organizes initiatives such as travel awards, leadership conferences, and socials like happy hours, sporting events and diversity fairs. Methodist Academy Council of Deans The Methodist Academy is governed by the the Research Institute Council of Deans (“Council”), which includes members of the Institute of Medicine, National Academy of Sciences, and National Academy of Engineers. In addition to serving as the scientific and strategic advisory board to the Research Institute president and CEO on academic research and education, the Council also works to promote the Research Institute in the academic community, provide guidance and mentorship to the Research Institute faculty members, and support integration of research and education between the Research Institute and home institutions. The members of the Council serve a life-long term and meet twice a year to discuss strategic initiatives and academic organizational development. Methodist Academy Affiliation Agreement Process To fulfill the mission of the Methodist Academy, which is to develop educational and research partnerships that foster medical innovation, we will form affiliation agreements with strategic partner institutions. The legal department of The Methodist Hospital System has drafted a template agreement that serves as the foundation for the initiation of negotiations with candidate partner institutions. If the partnering institution requests changes or edits, it must go back to our legal department for review and approval before being signed by executive administration from the Research Institute and the partnering institution. Criteria that are considered when considering partnership with a domestic or international partner include: • Academic strength and reputation 4 • • • • • Strategic alignment of interests in research/education/clinical offerings (aligned with the Methodist Centers of Excellence) Willingness to invest financial resources into the partnership Opportunities to secure joint funding that are mutually beneficial Philanthropic development potential for the Research Institute Revenue generating opportunities for The Methodist Hospital System The Research Institute Training Plan In order to advance training and research opportunities, the institute has established technical and service core facilities with expert leadership to provide service, training and guidance in advanced research technologies. Facilities and services offered include cyclotron cGMP radiopharmaceutical production, a machine shop, genomic sequencing, proteomics, advanced tissue and cellular imaging, biomedical informatics support, biostatistics support, comparative medicine, flow cytometry, electron microscopy, molecular diagnostics, preclinical catheterization, preclinical imaging, preclinical model development, research pathology, and a serum and tissue biorepository. The Research Institute research members have opportunities for affiliate faculty appointments at partnering academic institutions and participate in academic training by providing interactive courses in high impact research publications, professional seminars, and problem-based learning and technology-driven training sessions. Research topics are team-taught with experts highlighting their areas of expertise. The Research Institute faculty members provide quarterly progress reports to parent institutions and participate in graduate student committee meetings. The majority of graduate training is co-directed by research members who have active research collaborations between the two institutions. Upon accepting graduate students, the Research Institute mentors agree to uphold high standards of mentorship, providing weekly meetings with the student. Mentors also establish timelines and milestones to ensure that the student’s research project is advancing at an acceptable rate. Every six months, the Methodist Academy Oversight Committee meets with the students and summarizes mentor evaluations to provide general feedback on mentoring, and recognize outstanding mentorship with academic awards. All graduate students present their general research topic to the Oversight Committee three months after their start date, and present their defined research topic, both in written and oral form, to their advisory committees at the six-month mark. The Research Institute mentors agree to support the academic guidelines and standards established by the partnering degree granting institutions. Please note that any signed Academic Affiliation Agreement between the Research Institute and an institution would supersede this current Training Plan. 5 Trainees Trainee Responsibilities All trainees of the Research Institute are to adhere to and are held accountable for the official human resources policies and procedures of The Methodist Hospital System. In particular, trainees are responsible for research policies and procedures including but not limited to: Standard Operating Procedures for Good Clinical Practices Laboratory Safety Manual The Research Institute Laboratory Specifics Hazards Training The Research Institute Controlled Access Reporting Laboratory Incidents/Reportable Events in the Research Institute Laboratory Facilities Trainees conducting research at the Research Institute under an affiliation agreement with their home institution or university are also expected to follow that institution’s procedures and abide by the regulations that they have set forth. Trainee Evaluations Trainees will evaluate their mentors and the training environment on an annual basis. Evaluations will be used to improve and strengthen our academic programs at the Research Institute. Evaluations will be conducted through the New Innovations software program. Trainees will receive an email notification with information on how to complete the online evaluation. Trainees with Visas Anyone who is not 1) a U.S. Citizen, 2) a lawful permanent resident of the United States (i.e. a green card holder), or 3) a protected class such as a refugee or asylee must hold a US immigration status that allows them to take part in Methodist activities, whether they are paid or unpaid. Human resources immigration specialists will determine whether a trainee has the appropriate visa status or requires sponsorship to participate in the Research Institute program. All visas must be reviewed and initiated by Methodist human resources immigration services. Michele Stelljes (mmstelljes@tmhs.org) or 832-667-6288 is the contact person for any and all visa related issues. Please refer to the following charts as a guide. 6 Visas At A Glance Visa Status F-1 J-1 H-1B TN NAFTA Purpose Full time study in US degree programs Degree-specific Trainee’s F-1 students authorized eligible for by their US College or visa University for the specific authorization the Research Institute activity. A category of FN that may be paid? Yes or no, as authorized by F-1 School Officer at the US College or University. Processing Times CPT subject to school processing (subject to third party processing changes) OPT subject to government processing Employment visa for Canadian and Mexican Temporary worker in a professionals Research, and specialty occupation non-clinical training Employer-specific Employer-specific Sponsor-specific International EXCHANGE Employment Graduates of a 4 Graduates of a 4 year Workers that possess year Bachelors Bachelors or advanced the background and degree program, credentials for the degree program in the graduate program, position as listed in the specialized field of or student enrolled NAFTA Appendix employment in a master or Methodist job offer Methodist job offer doctoral program required required Methodist or third party J-1 program sponsorship required Yes or no, as allowed for unpaid positions Yes Yes Outside USA: 60 to Outside USA or Outside USA: 21 to 60 90+ days change of status: 90 to days 180 days Transfer: 40 to 60 days Transfer/porting an H1B: 55 to 180 days 7 Visa Status B-1 B-2 ESTA Visa Waiver (WB/WT) Dependents PURPOSE Business visits, observation, conference attendance, limited collaborations, or medical school electives. Tourism Site-seeing, visiting family, permitted to watch, observe See B-1 & B-2 Solely to join spouse or parent Not available for most students and trainees Not available for most students and trainees No No A category of FN that may be paid? May not enroll in courses, volunteer or train Only certain visas categories offer an option for work authorization (i.e. L-2 and J-2) Yes, ONLY with an unexpired EAD If medical insurance is not being offered through the trainees’ employment offer at the Research Institute, the trainee may contact Chartis Educational Markets at www.studentinsurance.com to find information regarding their college student health insurance program. For a J-1 student, insurance coverage is a requirement that must be met by the student. Trainee Problem Resolution Plan Trainee issues and/or concerns should first be discussed with the supervisor/mentor. If a resolution cannot be found at this level, then the trainee should contact Amy Wright, project manager of the Methodist Academy (aswright@tmhs.org or 713-441-7267) who will evaluate the issue and if needed, direct it to the appropriate Oversight Committee member. Dress Code Employees and visitors are expected to present themselves in a professional manner at all times and wear appropriate professional apparel. The following items are not allowed while on the Methodist campus: • • • • • • • Blue jeans or denim wear Flip flops or sandals Shorts Large, dangling earrings Exposed body piercings Exposed tattoos For those working in a laboratory environment, no open-toed shoes For additional information, refer to Policy HR16, Personal Appearance Guidelines, http://www.tmh.tmc.edu/HR/employeerelations/personal%20appearance%20guidelines.pdf 8 ID Badges All the Research Institute Trainees must wear their badges at all times while on the Methodist campus. In addition, Methodist employees and visitors are prohibited from loaning badges to anyone at any time, including other staff members. For individuals requiring access to badge restricted areas, contact Ms. Brenda Hartman at bkhartman@tmhs.org. For additional information, refer to Policy HR 34, Identification Badges, http://www/tmh.tmc.edu/reference/mhcsproc/hr/HR34.pdf Lab Notebooks It is a requirement of the Research Institute to keep all research records in a regulation lab notebook. Contact the Office of Technology Transfer: OTT@tmhs.org to obtain a lab notebook and all other questions regarding best practices for documentation. Laboratory Safety Procedures and Contacts In collaboration with Methodist Hospital Environmental Health and Safety, the Research Institute Laboratory Operations is focused on prevention of safety incidents and based on the Research Institute Safety ICARE values: Building up a safety culture foundation with a goal of excellence in safety standards and emergency procedures for the Research Institute research staff, students and visitors: I: Incidents/Safety Goal: No Incidents! C: Compliance with Safety Regulations A: Accountability R: Respect Hazardous Materials E: Excellence in Safety Standards The Research Institute onboarding/credentialing process includes mandatory online training which covers general laboratory safety. This online instruction should be completed before or immediately after the trainee arrives to begin work at the Research Institute. The trainee will receive additional safety guidelines from the Research Institute Laboratory Operations, and their department, laboratory manager and mentor. The Research Institute Institutional Standard Operation Procedures (SOP) and the TMH Chemical Hygiene Plan also provide safety guidance to all research laboratories. TMHS Chemical Hygiene Plan: http://www/dept/Safety/Program_Lab.htm The Research Institute research policies and procedures: http://www.tmh.tmc.edu/refernce/mhcsproc/research/tmhri/research_tmhri_index.htm Each Research Department Laboratory develops and follows their lab-specific safety manual which includes Safety procedures for the hazards used in that specific lab. 9 In addition to the trainee’s mentor and laboratory manager, contact persons for safety related questions and issues include: Roy (Karoly) Meszlenyi Manager, Laboratory Operations Office: 713-441-7311 Cell: 832-370-0647 E-mail: kmeszlenyi@tmhs.org Brenda Hartman Director, Laboratory Operations Office: 713-441-5841 Cell: 281-753-7026 E-mail: bkhartman@tmhs.org Mike Metcalf Safety Representative Office: 713-441-8262 Cell: 832-205-4568 E-mail: mametcalf@tmhs.org Cesar Villarreal Safety Representative Office: 713-441-8263 Cell: 281-831-1576 E-mail: cavillarreal@tmhs.org Mario Soares Safety Director Office: 713-441-0719 Cell: 281-740-6983 E-mail: mksoares@tmhs.org Onboarding Process The Research Institute Trainees must go through the onboarding process which includes TMHS human resources and the Research Institute orientation sessions. For credentialing, trainees should contact tmhricredentialing@tmhs.org or 713-441-5845. Paid Time Off (PTO) Trainees that qualify as eligible employees are able to earn time for approved absences such as vacation, holidays, personal reasons, severe weather, emergencies, family illnesses and short-term personal illness. All scheduled PTO must be approved by the trainee’s mentor and/or department administrator. Trainees must follow their department policy to determine whom to call for unscheduled absences. For additional information, refer to Policy HR25, Paid Time Off. http://www.tmh.tmc.edu/refernce/mhcsproc/hr/hr25.pdf Payroll The Research Institute trainees that receive compensation will be paid on a bi-weekly basis (every two weeks). The payroll schedule is attached as an appendix. Please expect U.S. taxes to be taken from your paycheck. If you are eligible for a reduction in your taxes, or benefit from a tax treaty, you may contact Diane Zakrzewski, Human Resources Payroll Coordinator, at DZakrzewski@tmhs.org upon arrival with your inquiries. 10 2013 Payroll Periods Pay Period Number Begin Date (Sunday) End Date (Saturday) Official Payday 1 12/16/2012 12/29/2012 1/3/2013 2 12/30/2012 1/12/2013 1/17/2013 3 1/13/2013 1/26/2013 1/31/2013 4 1/27/2013 2/9/2013 2/14/2013 5 2/10/2013 2/23/2013 2/28/2013 6 2/24/2013 3/9/2013 3/14/2013 7 3/10/2013 3/23/2013 3/28/2013 8 3/24/2013 4/6/2013 4/11/2013 9 4/7/2013 4/20/2013 4/25/2013 10 4/21/2013 5/4/2013 5/9/2013 11 5/5/2013 5/18/2013 5/23/2013 12 5/19/2013 6/1/2013 6/6/2013 13 6/2/2013 6/15/2013 6/20/2013 14** 6/16/2013 6/29/2013 7/3/2013 15 6/30/2013 7/13/2013 7/18/2013 16 7/14/2013 7/27/2013 8/1/2013 17 7/28/2013 8/10/2013 8/15/2013 18 8/11/2013 8/24/2013 8/29/2013 19 8/25/2013 9/7/2013 9/12/2013 20 9/8/2013 9/21/2013 9/26/2013 21 9/22/2013 10/5/2013 10/10/2013 22 10/6/2013 10/19/2013 10/24/2013 23 10/20/2013 11/2/2013 11/7/2013 24 11/3/2013 11/16/2013 11/21/2013 25 11/17/2013 11/30/2013 12/5/2013 26 12/1/2013 12/14/2013 12/19/2013 **Due to Holiday, Payday is scheduled for Wednesday 11 Trainee Travel Guidelines All trainees must adhere to the Research Institute Travel Policy RE-73 regarding travel. In order for trainees to be authorized to attend a seminar or conference on behalf of the Research Institute, the trainee must provide documentation of selection to give a presentation or poster at the conference. Otherwise, the mentor of the trainee must receive permission from their department administrator and justify the trainee travel. Resources/Useful Information BigMail The size limit for email attachments sent or received from a Methodist email account is 10 MB, but often our attachments exceed this limit. Methodist IT has set up the BigMail system for use with both internal and external recipients. Simply point your browser to https://bigmail.tmhs.org and provide your email address and network password to begin. External recipients must first be invited to use BigMail. To do this, send an email to the recipient through the BigMail system. They will be asked to create a username and password, and will then have access to this feature. Computer Support The IT Help Desk handles all computer needs, including computer set up and any technical issues that may arise. Call the IT Help Desk at 832.667.5600 or send an email to HELPDESK@tmhs.org. Housing There are multiple apartment complexes located adjacent to the Texas Medical Center that allow easy access to the Research Institute. You may contact Karen Reichek at Apartment Directions, and she will assist you in finding a short or long term lease in your price range. Her contact information is: Karen Reichek: Kreichek@aol.com 713-789-3777 or 713-826-6527 Apartment Directions 3300 Chimney Rock, Suite 104 Houston, TX 77056 Please note that all students should come prepared with sufficient financial resources to cover at least one month of living expenses including housing, food, rent deposits and miscellaneous items. It may take up to a month before students receive Methodist stipends or salaries, if applicable. Library Access From the Methodist network, you can access Library Services from http://www/Library/home.htm, or click the “TMHS library resources” link under “reference information” on the bottom right of the intranet home page (http://www.tmh.tmc.edu/). Methodist has access to hundreds of electronic journals and reference books. If you need an article from a journal to which Methodist does not have access, access the A-Z: Electronic Books & Journals site, and click the "Citation Search" in the top tab. You can search for the article (e.g. PMID number from PubMed, or volume/page number), the form will auto fill, and clicking the “Submit” button will send it to Library Services for interlibrary loan. The article is usually sent to you in PDF format within two days. For additional information please contact Linné Girouard at lgirouard@tmhs.org or 713-441-2229 To access electronic journals from outside the Methodist network, please contact the IT help desk to set up a VPN account which will allow you to access the network remotely. 12 Houston Metro Transit Information METRO's combination of services, including bus, train and vanpool, helps area residents and visitors meet their unique transportation challenges. In order to take advantage of the transit system, you must obtain a Houston Metro Q Card. This unique card contains a computer chip that stores a cash balance directly onto your card. Fares are automatically deducted from your card each time you ride, just like a debit card. To find out bus schedules, locations to buy a Metro Q card, and all other information for Metro, please go to: https://ridemetro.org Fare Zone Chart Routes Fare Discounted Fare Students, Seniors, Medicare Cardholders and Disabled Local / METRORail $1.25 per ride $0.60 per ride Park & Ride Zone 1 $2.00 per ride $1.00 per ride Park & Ride Zone 2 $3.25 per ride $1.60 per ride Park & Ride Zone 3 $3.75 per ride $1.85 per ride Park & Ride Zone 4 $4.50 per ride $2.25 per ride (See map on next page) 13 14 Parking If you are a Research Institute employee, then you may contact Geneence Jones in Parking at 713441-5655 for instructions for obtaining a parking or Metro Q card. If you are a Research Institute Visitor, you may park in any of the garages listed below, or use the Metro Transit system. After Hours Parking Trainees with assigned parking in Smith Lands or Southwest Extension lots may park in TMC Garage 1 or 7 on weekdays after hours between 6 p.m.-8 a.m. and all day on weekends and METRO holidays. Trainees are assigned to the West Pavilion can park in Smith Garage only on weekends. There is no weekday after-hours assignment for this lot. To access garage 1 or 7 during these hours, trainees should use their standard parking card that is used to access the remote lots. Questions on parking? Contact Geneence Jones at GLJones@tmhs.org 15 Security Escort If a trainee is working after hours or on the weekends and would like a security escort to and from their office to the parking garage, contact the Security Dispatch at extension 1-9511. TMC Maps and Information The Texas Medical Center (TMC) is the largest medical center in the world, with over 60 member institutions. Parking information, detailed maps and directions, and general information on the TMC can be found at http://www.texasmedicalcenter.org. 16 Alcohol The legal age to drink in the U.S. is 21. Consumption of alcohol is not permitted on The Methodist Hospital grounds and any trainee under the age of 21 may not consume alcohol at any Research Institute sponsored events. Smoking You are not allowed to smoke in any area of The Methodist Hospital System (which includes the ramps or walkways to the buildings). In addition, the City of Houston has a mandatory ordinance as well as a fire code prohibiting smoking in public areas. It is a misdemeanor offense with a fine of up to $200 to smoke in elevators, places where combustibles are sold, supermarkets, clothing stores and other retail establishments. New Tobacco-Free Hiring Policy: Effective January 1, 2013, Methodist will no longer hire tobacco users. Applicants will be tested for tobacco/nicotine products usage, including nicotine gum and patches, during the post-offer physical. If an applicant tests positive for tobacco use, the offer will be rescinded and individuals will be given the opportunity to participate in a free Methodist-provided tobacco cessation program. Applicants wishing to reapply after testing positive for tobacco may do so 90 days after the date the initial offer was rescinded. Drivers License The Texas Department of Public Safety implemented proof of residency requirements to obtain a first-time Texas driver license or identification card. To review the requirements necessary to obtain a license or identification card, you may go to the website: (http://www.txdps.state.tx.us/DriverLicense/identificationrequirements.htm). To meet the residency requirement for an original identification card or driver license, an applicant must: • Reside in Texas for at least 30 days prior to application • Present two acceptable documents establishing proof of residency, one of which must demonstrate the applicant has lived in Texas at least 30 days The 30-day requirement is waived for applicants who surrender a valid, unexpired out-of-state U.S. driver license, but two documents establishing proof of residency are still required. For a complete list of acceptable residency documents and additional details, please visit http://www.txdps.state.tx.us/DriverLicense/residencyReqNonCDL.htm. The minimum age for a TDL is 18. Individuals between the ages of 16 and 18 can obtain a license if they have successfully completed an approved driver’s education course. Age 15 can obtain a hardship authorization, which permits a student driver to legally practice when accompanied by a licensed driver who has had at least one year of driving experience. In all situations regarding minors, applications must be signed under oath by a parent or guardian willing to assume with applicant the responsibility for any negligence or misconduct on minor’s part while driving. Most officials at the area offices are notaries public. For further information, and driver license locations, please call the: Texas Department of Public Safety 713-681-6187 http://www.txdps.state.tx.us 17 Social Security To obtain your social security card, you must apply in person at the following address: SOCIAL SECURITY 8989 LAKES AT 610 DR HOUSTON, TX 77054 For more information, call toll-free at 1-800-772-1213, Monday through Friday between 7 a.m. and 7 p.m. or go to http://www.ssa.gov/ssnumber/ss5.htm. Vehicle Registration New residents must register and title their out-of-state licensed vehicles within 30 days of establishing residence or beginning employment in Texas. All applications for a Texas Certificate of Title and Registration must be filed with the Harris county tax assessor-collector at the Harris County Administration Building, 1001 Preston, or at any of the ten area sub-stations. Before registering a vehicle, a new resident must have it inspected at an authorized state inspection station. These stations are identified by a sign with a Texas State Silhouette. State inspections are valid for one year following the inspection. The new resident must then proceed to the Tax Assessor-Collector’s office or a sub-station. It is necessary to bring the green inspection form (obtained at the inspection station), the amount of mileage on the car, the last registration and title, and proof of insurance. If there is a loan on the car, bring the name and address of the lien holder. The person in whose name the car is registered must be present to fill out the application. Voting To vote in Texas a person must be a U.S. citizen at least 18 years of age, not be a convicted felon, not have been ruled mentally incompetent, and be registered to vote. To register to vote, obtain a voter’s registration certificate through the County tax assessor-collector’s office at 1001 Preston Street, Houston Texas 77002, Room 100 or any branch offices. Phone: 713-368-2000 for an application. Voting eligibility begins 30 days from the registration certificate date. Applications become permanent registrations with new certificates issued biennially. For information on polling locations call 713224-1919. 18 Useful Phone Numbers Emergency Numbers Houston Police, Fire, Ambulance- 911 Red Cross- Disaster Relief 713-526-8300 Dental Referral 713-961-4337 Doctor Referral 713-942-7050 Voter Registration 713-224-1919 Library 832-393-1313 Post Office 800-275-8777 Transportation Auto Registration 713-224-1919 Metro 713-635-4000 Carpool 713-224-7433 Vanpool 800-826-RIDE Yellow Cab 713-236-1111 Bush Intercontinental Airport 281-230-3100 Hobby Airport 713-640-3000 Greyhound Bus 713-759-6565 Amtrak 713-224-1577 Utilities Reliant Energy (electric) 713-207-7777 Centerpoint Energy (gas) 713-659-2111 Power to Choose 866-797-4839 Utex (electric) Southwestern Bell 1-800-464-7928 MCI 800-950-5555 AT&T 888-944-0447 Water-Harris County 713-371-1400 (city limits) Cable Options AT&T- www.att.com Comcast- www.comcast.com Direct TV- www.directtv.com Dish- www.dish.com 19 Appendix 20 TMHRI Translational & Clinical Research Building Floor 12: cGMP Manufacturing Facility Floors 10-11: Shelled Laboratories Floor 9: Cancer Research Inflammation & Epigenetics TMHRI Floor 8: Diabetes & Metabolic Disease Nanomedicine Floor 7: Cancer Research & Nanomedicine TMH Floor 6: Infectious Disease Systems Medicine & Bioengineering Translational Imaging Transplantation Biology Floor 5: MITIE Innovation & Education Floors 3 & 4: Vivarium Floor 2: Auditorium & Boardroom Floor 1: Imaging Suite, Reception & Valet Basement: Cyclotron & Hot Cells 21 The Research Institute Departments, Programs, and Cores The Research Institute Departments Nanomedicine The Department of Nanomedicine provides the infrastructure for the development of fundamental platforms including silicon/semiconductors, nano/microfabrication, mathematics, molecular medicine and pharmaceutical technologies. http://www.methodisthealth.com/Nanomedicine Systems Medicine and Bioengineering The Department of Systems Medicine and Bioengineering seeks cures and improvements in disease diagnosis and treatments with computational, chemical and systems biology, imaging, physics, biophotonics and bioengineering technologies that manage and integrate patient data with the information generated by large scale research studies. http://www.methodisthealth.com/smb Translational Imaging The Department of Translational Imaging partners researchers with clinicians to develop new translational imaging materials and technologies that improve patient diagnosis, therapy, and outcomes. http://www.methodisthealth.com/translationalimaging The Research Institute Programs Cancer The cancer research program at the Research Institute is one of the largest in Texas, with basic,clinical, and translational studies covering many types of cancer including breast, endometrial, genitourinary, and prostate. http://www.methodisthealth.com/cancerresearch Cardiovascular Disease The cardiovascular disease program at the Research Institute focuses primarily on atherosclerosis, acute coronary syndromes, arrhythmia, atrial and ventricular fibrillation, and heart failure. http://www.methodisthealth.com/tmhri.cfm?id=36369 Diabetes and Metabolic Disease The diabetes and metabolic disease research program at the Research Institute will conduct a wide range of investigational studies into the mechanisms of diabetes, obesity, insulin resistance, metabolic syndrome, tissue damage, and islet cell dysfunction. http://www.methodisthealth.com/tmhri.cfm?id=36354 Infectious Disease The infectious disease and inflammation research program at the Research Institute focuses on several significant causes of human infection including group A Streptococcus (strep throat, flesh eating disease), tuberculosis, and Vibrio cholerae. http://www.methodisthealth.com/tmhri.cfm?id=36324 Neurosciences The neurosciences research program at the Research Institute concentrates on investigations of amyotropic lateral sclerosis (ALS), Parkinson's Disease, medically refractory dystonia, stroke, primary brain tumors, and stuttering. http://www.methodisthealth.com/tmhri.cfm?id=36287 Transplantation Immunology The transplantation immunology research program at the Research Institute directs its studies on the minimization of postoperative complications for heart, lung, liver, and kidney transplantation. http://www.methodisthealth.com/tmhri.cfm?id=36268 22 Programmatic Cores Genomic Medicine The genomic medicine program conducts research in nuclear hormone receptor genomic regulatory mechanisms, and oversees a Next Generation genomic sequencing core that provides services to the Research Institute researchers. http://www.methodisthealth.com/genomicmedicine Proteomics The Proteomics Programmatic Core at the Research Institute is dedicated to enhancing the clinical and translational research capabilities of the Institute by providing scientific and technical support for proteomics-related research. http://www.methodisthealth.com/proteomics Tissue Engineering & Regenerative Medicine The tissue engineering & regenerative medicine program was established to advance the field of cellbased therapies, and to support the Research Institute investigators in their research involving pluripotent stem cells to treat human diseases. http://www.methodisthealth.com/tmhri.cfm?id=36229 Technical Cores Advanced Tissue & Cellular Imaging Core (Lab Locations: RIB R6-212, MC: R6-414 The Research Institute Advanced Cellular and Tissue Microscopy Core Laboratory is a core lab providing the Research Institute community and Texas Medical Center community access to advanced high-performance microscopy for cell biology and tissue pathology studies. http://www.methodisthealth.com/tissue-cellular-imaging Biomedical Informatics Support Core The Biomedical Informatics Support Core is operated by the Department of Systems Medicine and Bioengineering at the Research Institute, and it focuses on the development and integration of many different informatics capabilities at Methodist. http://www.methodisthealth.com/biomedical-informatics Center for Biostatistics Core The Center for Biostatistics (CFB) is a service and research core of the Research Institute. Its staff provides biostatistical services to NIH-funded researchers and MPO clinicians. CFB operates through a charge back system and is a fee-for-service core. http://www.methodisthealth.com/biostatistics Comparative Medicine Core The Methodist Hospital Research Institute’s Comparative Medicine care and use program is registered with the USDA (74-R-0192) and has an assurance (A4555-01) with the Public Health Service (PHS) stating that we will remain in compliance with the PHS Policy on Humane Care and Use of Laboratory preclinical study models. http://www.methodisthealth.com/comparativemedicine Flow Cytometry Core The core maintains three instruments, a BD LSRII, FACS Fortessa, and FACS Aria II. These instruments allow scientists to make very concise measurements at the cellular level, evaluate a large number of samples in a short time frame, and gather information on very rare populations of cells. http://www.methodisthealth.com/flowcytometry Preclinical Imaging Core Provides researchers access to resources, services, and expertise necessary to perform multimodality imaging studies on preclinical study models, including PET, SPECT, CT, MRI/MRS, ultrasound, and optical imaging. http://www.methodisthealth.com/preclinicalimaging Preclinical Model Development Core The mission of the Preclinical Model Development Core is to provide high quality state-of-the-art physiological testing. http://www.methodisthealth.com/preclinical-model-development Research Pathology Core The Research Pathology Core is now providing histology and immunohistochemistry services in support of research projects. http://www.methodisthealth.com/researchpathology 23 Scanning Electron Microscopy Core Our high resolution imaging core is equipped with a Nova NanoSEM Scanning electron microscope and two atomic force microscopes, the Multimode and the Catalyst. This equipment provides data on the surface topology of specimens, such as cells, cellular components, or particles. http://www.methodisthealth.com/SEM Serum and Tissue Biorepository Core This core is a resource that helps further the goal of translating the scientific discoveries into the best treatment for our patients. It is a large, general-purpose Biorepository and associated database of preselected and randomly selected specimens for use by researchers within the Research Institute and their collaborators. http://www.methodisthealth.com/serum-tissue-biorepository Service Cores Academic Office of Clinical Trials The Academic Office of Clinical Trials (AOCT) provides leadership for clinical trials operations and provides new and experienced investigators with staff resources to maximize the Research Institute’s ability to conduct innovative clinical research. http://www.methodisthealth.com/clinical-trials-core Machine Shop Core This core is responsible for design, prototype, manufacture and repair small instruments, tools, and parts. 24