Curriculum Vitae Sebastian Lippross

Curriculum Vitae
Sebastian Lippross
Address
Klinik für Unfallchirurgie
UKSH Kiel
Arnold-Heller-Str.3
Haus 3
D-24118 Kiel
Germany
Contact number
+49-431-597 4581
Mobile
+09-152 29208094
E-mail
sebastian.lippross@uksh-kiel.de
GMC No.
6090569
Date of Birth
22 March 1977
Nationality
German
Qualifications:
Specialist (“Facharzt”) in Orthopedics and
Traumatology (2010)
German State Exam (=MBChB)
Doctoral Thesis
published in Nature Neuroscience
Habilitation Thesis (=PhD thesis)
Emergency Medicine Diploma
International Diploma in Altitude Medicine
Current employment:
Since April 2010
Specialist Surgeon in Traumatology
University Hospital of Schleswig-Holstein, Campus
Kiel, Germany
Administrative deputy of the Baltic Trauma Center
Current work duties Treatment of all kinds of acute musculoskeletal
trauma including multiple injuries on a daily basis
Student teaching and lectures at the Medical School
of the University of Kiel
Supervision of surgeons in training
Work experience
March 2007April 2010
Specialist Training Orthopedics and Trauma
University Hospital of Schleswig-Holstein, Campus
Kiel, Germany, Professor Dr. Andreas Seekamp,
FACS
February 2006March 2007
Raetia Stipend 2006 AO Foundation
Research Fellow AO Research Institute,
February 2005February 2006
Assistant Doctor in Orthopaedics
University Hospital of Schleswig-Holstein, Campus
Kiel, Germany
August 2004February 2005
PRHO in Orhtopaedics/General Surgery/
Anaesthetics
Queen Alexandra Hospital, Portsmouth, Great
Britain
FebruaryAugust 2004
PRHO in Internal Medicin, Furness General
Hospital, Barrow in Furness, Great Britain
Research& Audit
Current work
Fracture Healing, Osteoporosis, Degenerative
Arthritis
(Animal Experiments, Biomechanics, Molecular
medicine)
2005-2012
“Habilitation” (Venia Legendi): “In-vitro and in-vivo
investigations on the clinical applications of Plateletrich Plasma” at the Medical Faculty of the University of
Kiel, Germany
2000-2002
Doctoral Thesis, summa cum laude: PGE2 inhibits
nociceptive glycine signaling in the rat dorsal horn
Student doctoral fellowship of the German Research
Foundation (DFG) for experimental work at the Department
of Experimental and Clinical Pharmacology and Toxicology
of the University of Erlangen-Nuremberg,
2005
Audit on Sleep Apnoe, Furness General Hospital,
Barrow in Furness, UK
2004
National audit on case notes, Portsmouth NHS Trust
Frequent reviews
European Cells and Materials
(Impact Factor 9.6)
Annals of Anatomy
Journal of Cranio-Maxillofacial Surgery
Grants
2006
2007
2008
2009
46,000 Euro Medical Faculty of the University of Kiel
12,000 Euro Medical Faculty of the University of Kiel
15,000 Euro AO Foundation Germany
76,000 Euro Medical Faculty of the University of Kiel
57,000 Euro Medical Faculty of the University of Kiel
Awards
2002
2009
German Award in Pain Research
Poster award of the German orthopedic society
(DKOU) for the abstract “Platelets and Polytrauma”
2010
Research Award of the AXIS-Foundation
„Investigation of chondrogenic potential of
mesenchymal stem cells from intraarticular drainage
fluid after arthroscopic procedures“
Courses attended:
Vascular Surgery
01/2009
AO Advanced
12/2007
AO Spine trauma
ATLS
04/2007
AO Principles
12/2006
AO Spine degenerative
ALERT
04/2004
Fellowships/Stipends
2006-2007
Raetia Stipend 2006 of the AO Foundation
2005
Fellowship for junior scientists in orthopaedics of the
German orthopaedic association
2000-2003
Student doctoral fellowship of the German Research
Foundation (DFG)
University
1997-2003
Medical school of the Friedrich-Alexander-University
Erlangen-Nuremberg, Germany
University of Kwazulu-Natal, South Africa
Student teaching
1999-2002
2005
2006
Student courses in Anatomy, Biochemistry and
Pharmacology as a tutor
Student courses in orthopaedics
Student courses in trauma surgery
Publications
Educational
Lippross S. (2011) Student Guide „My first day in orthopedics and trauma“, University
Medical Center of Schleswig-Holstein
Scientific
Möller B., Terheyden, H., Acil, Y., Tulowitzki, A., Lippross, S., Wiltfang, J. Prvention of
the surface resorption of bone grafts by topical application of bisphosphonate on
different carrier materials. submitted
Lippross S, Beckmann R, Özdogru F, Lichte P, Steubesand N, Tohidnezhad M,
Brüggemann S, Graeff C, Kann YW, Fischer H, Drescher W, Tingart M, Pape C,
Seekamp A, Varoga D, Campbell G, Glüer CC, Pufe T, Wruck C (2012) Impaired
Fracture healing in Nrf-2 Knockout Mice, Histochem Cell Biol in revision
Lippross S, Tohidnezhad M, Wruck CJ, Podschun R, Brandenburg LO, Seekamp A ,
Varoga D, Pufe T (2012) Platelet-released growth factors can induce the Nrf2-ARE
pathway and VEGF in SAOS cells PloS One under second revision
Lippross S, Moeller B, Haas H, Tohidnezhad M, Steubesand N, Wruck CJ, Seekamp
A, Pufe T, Varoga D (2011) Intraarticular Injection of Platelet-rich plasma reduces
inflammation in a house swine model for rheumatoid arthritis of the knee joint Arthritis
Rheum. Nov;63(11):3344-53
Lippross S, Tohidnezhad M, Podschun R, Wruck CJ, Seekamp A, Brandenburg LO,
Varoga D, Pufe T (2011) Thrombocyte-derived human beta-defensin 2 is a potent agent
against common orthopaedic infections Platelets 23(3):217-23.
Lippross S, Loibl M, Hoppe S, Benneker L, Alini M, Verrier S (2011) Platelet Released
Growth Factors boost expansion of Bone Marrow derived CD34+ and CD133+
Endothelial Progenitor Cells for Autologous Grafting. Platelets.22(6):422-32
Tohidnezhad M, Varoga D, Podschun R, Wruck CJ, PhD, Seekamp A, Brandenburg
LO, Pufe T, Lippross S (2011) Thrombocytes are effectors of the innate immune
system releasing human beta defensin-3 Injury. Jul;42(7):682-6
Lippross S, Kluter T, Oestern S, Mentlein R, Hildebrandt F, Podschun R, Pufe T,
Seekamp A, Varoga V (2011) Multiple trauma induces serum production of host
defense peptides. Injury. Feb;43(2):137-42
Lippross S, Tohidnezhad M, Wruck CJ, Podschun R, Brandenburg LO, Seekamp A,
Varoga D, Pufe T (2011) Platelet-released growth factors can accelerate tenocyte
proliferation and activate the anti-oxidant response element. Histochem Cell Biol
May;135(5):453-60
Oestern S., Neunaber C., Steubesand N., Varoga D., Lippross S., Hildebrand F., Rau
A., Buddrus B., Seekamp A. Schock- und nun? chirurgische Praxis 2010
Christoph Jan Wruck, Athanassios Fragoulis, Agata Gurzynski, Lars-Ove
Brandenburg, Yuet Wai Kan, Joachim Hassenpflug, Sandra Freitag-Wolf, Deike
Varoga, , Thomas Pufe, Sebastian Lippross. Role of oxidative stress in rheumatoid
arthritis: insights from the Nrf2-knockout mice, Ann Rheum Dis. May;70(5):844-50.
Besch L, Waldschmidt JS, Daniels-Wredenhagen M, Varoga D, Mueller M, Hilgert RE,
Mathiak G, Oestern S, Lippross S, Seekamp A.´The treatment of intra-articular
calcaneus fractures with severe soft tissue damage with a hinged external fixator or
internal stabilization: long-term results. J Foot Ankle Surg. 2010 Jan-Feb;49(1):8-15.
Varoga, D, Klostermeier E, Paulsen F, Wruck, C, Lippross, S, Brandenburg, L,
Tohidnezhad, M, Seekamp, A, Tillmann, B, Pufe, T: The antimicrobial peptide HBD-2
and the toll-like-receptors-2 and -4 are induced in synovial membranes in case of septic
arthritis. Virchows Arch. 2009 Jun;454(6):685-94
Varoga D, Tohidnezhad M, Paulsen F, Wruck CJ, Brandenburg L, Mentlein R,
Lippross S, Hassenpflug J, Besch L, Müller M, Jürgens C, Seekamp A, Schmitt L, Pufe
T: The role of human beta-defensin-2 in bone. J Anat. 2008 Dec;213(6):749-57
Lippross S, Prange, G, Oehlert, K, Seekamp A Varoga D,: Breitensport erhöht die
Stabilität des Kniegelenkes und vermindert Risikofaktoren der weiblichen VKB-Ruptur Z
Orthop Unfall. 2010 Mar;148(2):210-4.
Varoga D, Drescher W., Lippross S, Pufe T, Schuetz R. Nonsteroidal AntiInflammatory Drug (NSAID)-Related Spontaneous Compartment Syndrome Resulting
From Severe Platelet Dysfunction J Trauma. 2008 Feb 15
Verrier.S., Meury, T., Lippross.S., Alini, M. An Engineered Vascularized Graft For
Large Bone Defect, European Cells and Materials Vol. 13. Suppl. 2, 2007 (38-40)
Schlickewei, C, Verrier, S., Lippross, S., Pearce, S., Alini, M. Interaction of Bone
Marrow Stromal Cells with Biodegradable Polyurethane Bone Substitutes Macromol.
Symp. 2007, 253, (162–171)
Lippross, S., Seekamp, A. Kommentar; Erweiterte präklinische Massnahmen vor der
Thorakotomie in der Notaufnahme: „Einpacken und Losfahren“ rettet Leben. Notfall
Up2Date, 12/2007
Lippross, S, Alini, M.,Platelet-released Growth Factors- To use or not to use? A
review, AO Dialogoue (1)04/2007
Varoga D, Paulsen FP, Kohrs S, Grohmann S, Lippross S, Mentlein R, Tillmann BN,
Goldring MB, Besch L, Pufe T. Expression and regulation of human beta-defensin-2 in
osteoarthritic cartilage.J Pathol. 2006 Jun;209(2):166-73.
Lippross, S., Ahmadi, S.,Neuhuber. W.L., Zeilhofer, H.U. (the two first authors
contributed equally) “PGE2 selectively blocks inhibitory neurotransmission onto rat
superficial dorsal horn neurons” Nature Neuroscience 2002:5:24-40
Abstracts and oral presentations:
Die intraartikuläre Injektion von Platelet-rich Plasma zur Behandlung der Kiefergelenkarthritis am Schweinemodell Möller,
Björn; Lippross, Sebastian; Varoga, Deike; Acil,Yahya; Jörg, WiltfangArbeitsgemeinschaft für Kieferirurgie / 32. Jahrestagung des
Arbeitskreises für Oralpathologie und Oralmedizin 2011
Role of Oxidative Stress in Rheumatoid Arthritis: New Insights from the NRF2-Knockout Mice, Thomas Pufe, Athanassios
Fragoulis, Sebastian Lippross, Rainer Beckmann, Mersedeh Tohidnezhad, Andreas Seekamp, Melanie Pufe, Yuet W Kan, Deike J
Varoga, Christoph J Wruck
Role of Platelet Rich Plasma (PRP) in fracture healing: new insight
Mersedeh Tohidnezhad; Christoph Wruck; Deike Varoga; Sebastian Lippross; Wolf Drescher; Thomas Pufe
ORS 2011, Long Beach
In vitro-modified human peripheral blood monocytes for bone healing
Nadine Steubesand; Stefanie Oestern; Björn Moeller; Fred Fändrich; Andreas Seekamp; Sebastian Lippross; Deike Varoga
ORS 2011, Long Beach
Intraarticular injection of platelet-rich plasma reduces inflammation in a house swine model for arthritis of the knee joint
Sebastian Lippross; Bjorn Moeller; Holger Haas; Mersedeh Tohidnezhad; Jan Christoph Wruck; Thomas Pufe; Andreas
Seekamp; Deike Varoga
ORS 2011, Long Beach
Impaired Fracture Healing In Nrf2-Knockout Mice
Sebastian Lippross; Ferda Oezdogru; Nadine Steubesand; Rainer Beckmann; Mersedeh Tohidnezhad; Claus Glueer; Christian
Graeff; Andreas Seekamp; Yet Kan; Deike Varoga; Jan Wruck
ORS 2011, Long Beach
Retrospektive Analyse der klinischen und röntgenologischen Ergebnisse
nach Implantation des Coflex-Titan-U an 198 Patienten
S. Lippross, I. Perner, M. Müller, R. Morrison, D. Adelt, A. Seekamp, D. Varoga
DKOU 2010 Berlin
PRP aktiviert den Transkriptionsfaktor Nrf2 bei der Frakturheilung
Tohidnezhad Mersedeh (Aachen), Lippross S., Herman
DKOU 2010 Berlin
Problemlösungen bei komplexen Frakturen des proximalen Femur
Müller M. (Kiel), Morrison R., Seitz A., Lippross
DKOU 2010 Berlin
Dorsale Stabilisierung von Frakturen der mittleren
Morrison R. (Kiel), Müller M., Seitz A., Lippross
DKOU 2010 Berlin
Untersuchungen zum chondrogenen Potential mesenchy
Hartz Claudia, Lippross S., Pries F., Puf
DKOU 2010 Berlin
Abstract:
Cartilage regenerating procedures define the concentration of growth factors
Hartz, C.Lippross, S, Hildebrand, F., Mentlein, R., Seekamp, A., Pufe, T., Varoga, D.
ORS 2010, New Orleans
Abstract
Blood Cells and Hepatocytes contribute to serum elvels of antimicrobial peptides in polytraumatized patients
Klueter, T, Oestern S, Lippross, S, Hartz, C., Hildebrand, F., Mentlein, R., Seekamp, A., Pufe, T., Varoga, D.
ORS 2010, New Orleans
Abstract
Untersuchungen zum chondrogenen Potential mesenchymaler Stammzellen nach knochenmarkstimulierenden
arthroskopischen Techniken
C. Hartz, S. Lippross, F. Pries, T. Pufe, A. Seekamp, D. Varoga;
Norddeutscher Orthopaedenkongress Hmburg 2010
Abstract:
Expression von LL-37 in der Leber und Im Serum von Polytraumapatienten
Klüter T Oestern S, , Klüter T, Lippross S, Pufe T Seekamp A Varoga D
DKOU 2009, Berlin
Abstract:
Expression von humanem beta-Defensin-2 und LL-37 im Serum von Polytraumapatienten
Oestern S, Klüter T, Lippross S, Pufe T Seekamp A Varoga D
DKOU 2009, Berlin
Abstract: PRP sezerniert Antimicrobielle Peptide
Tohiznedad M, Lippross S, Varoga D, Brandenburg LO, Pufe T
DKOU 2009, Berlin
Abstract: Der Einfluss knorpelstimulierender Operationsverfahren auf die intraartikuläre Synthese von anabolen
Wachstumsfaktoren nach Kniegelenkarthroskopie
D. Varoga, C. Hartz, F. Pries, T. Klüter, T. Pufe, A. Seekamp, S. Lippross
DKOU 2009, Berlin
Vortrag: Nrf2 reuliert die Kallusbildung bei der Fraktur der Maus
Lippross S, Oezdogru F, Pufe T, Gueer CC, Graeff C, Seekamp A, Varoga D
DKOU 2009, Berlin
Vortrag: Impaired fracture healing in Nrf2-Knockout mice
Lippross S, Oezdogru F, Pufe T, Gueer CC, Graeff C, Seekamp A, Varoga D
Chirurgische Forschungstage 2009, München
Abstract: Expression von humanem beta-Defensin-2 im Serum von Polytraumapatienten
Oestern S, , Klüter T, Lippross S, Pufe T Seekamp A Varoga D
58. Tagung der Norddeutschen Orthopädenvevreinigung, Hamburg, 18-20.Juni 2009
P71
Vortrag: Der Einfluss knorpelstimulierender Operationsverfahren auf die intraartikuläre Synthese von anabolen
Wachstumsfaktoren nach Kniegelenkarthroskopie
Hartz C, Lippross S, Klüter T, Pries F, Hedderich J, Seekamp A, Varoga D
58. Tagung der Norddeutschen Orthopädenvevreinigung, Hamburg, 18-20.Juni 2009
V10.04
Abstract: Induction of antimicrobial peptides in blodd of polytrauma patients.
Oestern S, Varoga D, Klüter T, Hildebrand F, Kurz B, Lippross S, Weuster M, Pufe T Seekamp A:
SHOCK SOCIETY THIRTY-SECOND ANNUAL CONFERENCE ON SHOCK
The Westin La Cantera Resort – San Antonio, Texas
June 6 – 9, 2009
Abstract: Platelet Released Growth Factors boost Expansion of Endothelial Progenitor Cells
S. Lippross, S. Verrier, D.Varoga, A.Seekamp, M. Alini
Poster No 735
DGU 2008
Abstract: The Toll-Like Receptors-2 and -4 Mediate the Bacterial Induction of
HBD-3 in Osteoblasts
Deike Varoga, Christoph Wruck, Sebastian Lippross, Andreas Seekamp,
Thomas Pufe
Poster No. 884
Orthopaedic Research Society, 54rd Annual Meeting, March 2-5 2007 11-14
Abstract: PRGF promotes and maintains the endothelial phenotype of endothelial
progenitor cells in vitro
Sven Hoppe, Sebastian Lippross, Lorin Benneker, Mauro Alini, Sophie Verrier
Poster No. 1081
Orthopaedic Research Society, 54rd Annual Meeting, March 2-5 2007 11-14
Oral Presentation: Bacterial Induction of the Antimicrobial Paptide BHD-3 in Osteoblasts is dependent on Toll-like
Receptor-2 and -4 and is not a Result of de-novo Synthesis
D. Varoga, T. Pufe, C. Wruck, S. Lippross, A. Seekamp
Chirurgische Forschungstage 2007
Langenbecks Arch Surg (2007) 392:769–838
Oral Presentation: Platelet Released Growth Factors boost Expansion of Endothelial Progenitor Cells
S. Lippross, S. Verrier, D.Varoga, A.Seekamp, M. Alini
Chirurgische Forschungstage 2007
Langenbecks Arch Surg (2007) 392:769–838
Abstract: Induction of Antimicrobial Peptides in Bacterial Bone Infection
Varoga, D; Lippross, S; Wruck, C; Mentlein, R; Seekamp, A; Pufe, T
EFFORT 2007
Abstract: Antimicorbial Peptides in inflammatory Joint Arthritis
Varoga, D, Lippross, S., Grohmann, S, Pufe, T.
Poster No 46
ECMVIII, Davos, Switzerland, June22-25. 2007
Oral Presentation: Platelet-released Growth Factors Boost Expansion of Endothelial Progenitor Cells.
Verrier, S., Lippross, S., Hoffmann, A., Schlickewei, C., Alini, M. ECMVIII, Davos, Switzerland, June22-25. 2007
Oral Presentation: Endothelial Progenitor Cells For Autologous Bone Grafting
Lippross, S,. Verrier, S., Hoffmann, A, Hoppe, S., Alini, M.
ECMVIII, Davos, Switzerland, June22-25. 2007
Abstract: Inflammatory Induction of Antimicrobial Peptides in Synovial Membranes
Lippross, S., Pufe, T., Klostermayer, E., Wruck, C., Grohmann, S., Harder, J., Varoga, D.
Poster No 730
Orthopaedic Research Society, 53rd Annual Meeting, February 11-14, 2007
Abstract: Platelet-Released Growth Factors Boost Expansion of Endothelial Progenitor Cells
Lippross, S., Verrier, S., Hoffmann, A., Alini, M.
Poster No 481
Orthopaedic Research Society, 53rd Annual Meeting, February 11-14, 2007
Abstract: Interaction of Bone Marrow Stromal Cells with Biodegradable Polyurethane Bone Substitutes
Schlickewei, S., Verrier, S., Lippross, S., Pearce, S., Alini, M., Gogolewski, S.
Poster No 59,
International Conference on Biomaterials in regenerative Medicine, Vienna, October 22-25, 2006
Abstract: Induction of Vascular Endothelial Growth Factor in Septic Joint Disease.
Varoga,D.,Grohmann, S., Fay, J., Kurz,B., Mentlein, S., Lippross,S., Tillmann, B., Goldring, M., Pufe, T.,
Trans Orthp Res Soc 2006;31:709
Oral presentation: Expression und Regulation von humanem beta-defensin in osteoarthrotischem Gelenkknorpel
Lippross, S., Schütz, R., Grohmann, S., Pufe, T., Varoga, D.
No.:E.2.1-1291,
DGU Jahreskongress Berlin 2006; 2.-7. September 2006
Abstract: Expression und Regulation von humanem beta-defensin-2 in osteoarthrotischem Gelenkknorpel
Lippross, S., Grohmann, S., Pufe., T., Mentlein, R., Varoga, D.
Poster no P30.10
55. Jahrestagung der Norddeutschen Orthopädenvereinigung e.V. Hamburg; 15-17.June 2006
Abstract: NF-κB- and AP-1- mediated induction of human beta defensin-2 (hBD-2) in human synoviocytes
E. Klostermeier, D. Varoga, S. Lippross, S. Grohmann, F. Paulsen, R. Mentlein, S. Kohrs, J. Harder, J.M. Schröder, S. Oestern , B.
Tillmann, T. Pufe
Poster No. 105
Anatomische Gesellschaft - 101st Annual Meeting Freiburg,Germany; April 7.-10.2006
Abstract: Expression and regulation of human beta-defensin-2 in osteoarthritic cartilage
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Lippross, S. , Varoga, D. , Paulsen, F.P. , Kohrs, S. , Grohmann, S. , Hassenpflug, J. , Tillmann, B.N. , Goldring, M.B. , Pufe, T.
Poster Nr. 324
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ORS 2006 52 annual meeting of the orthopaedic research society Chicago; 18.-23.March 2006
Oral presentation: PGE2 selectively blocks inhibitory glycinergic currents in rat dorsal horn neurons
Lippross, S., Ahmadi, S., Zeilhofer, H-U.
Erlangen Autumn School in pain research; 11.-13. October 2001
Audit
Audit on Sleep Study Service at Furness General Hospital, July 2004
Participated in national audit on case notes, Portsmouth NHS Trust 2005