13th Annual Meeting of the ECNM

Welcome to Munich
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Prof. Dr. med. Karl Sotlar Karl.Sotlar@med.uni-muenchen.de
Prof. Dr. med. Hans-Peter Horny Hans-Peter.Horny@med.uni-muenchen.de
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Institute of Pathology – Ludwig-Maximilians-Universität München
Thalkirchner Str. 36
80337 Munich, Germany
M
Gaig
Organizer
.
13th Annual Meeting of the ECNM
Munich, October 8 -10, 2015
Program Thursday, October 8
13:30 Welcome Coffee
14:00 Karl Sotlar & Hans-Peter Horny (Munich, Germany)
Welcome
14:10 Thomas Kirchner (Munich, Germany)
Welcome Notes
14:25 Emir Hadzijusufovic (Vienna, Austria)
ECNM Homepage
14:30 Michel Arock (Paris, France) & Peter Valent (Vienna, Austria)
Status of the ECNM in 2015
Session II: Mast Cell Activation and Allergy in Mastocytosis
Chairs: B. Nedoszytko & L.B. Schwartz
17:15 Sigurd Broesby Olson (Odense, Denmark)
Diagnostic Algorithm for Patients with Suspected Mastocytosis
17:30 Patrizia Bonadonna (Verona, Italy)
Hymenoptera Venom Allergy in Clonal Mast Cell Disorders
17:45 Hanneke Oude-Elberink (Groningen, Netherlands)
Treatment of IgE-Dependent Allergy in Mastocytosis
18:00 Cem Akin (Boston, USA)
Mast Cell Activation Syndrome: Update 2015
18:15 Boguslaw Nedoszytko (Gdansk, Poland)
Genetic Patterns Predisposing to Anaphylaxis in Mastocytosis
20:00 Faculty Dinner
14:40 Peter Valent (Vienna, Austria) & Michel Arock (Paris, France)
Presentation of the Researcher of the Year 2015
14:45 Lawrence B. Schwartz (Richmond, VA, USA)
Development of Tryptase as Biomarker in Mastocytosis
15:15 Coffee Break
Session I: Skin and Childhood Mastocytosis
Chairs: K. Brockow & C. Akin
15:45 Karin Hartmann (Cologne, Germany)
Heterogeneous cutaneous lesions in childhood-onset
mastocytosis
16:00 Luis Escribano (Madrid, Spain)
Lesional Patterns of CM in Children and Clinical Implications
16:15 Knut Brockow (Munich, Germany)
Treatment of Cutanous Mastocytosis in Children and Adults
16:30 Franziska Ruëff (Munich, Germany)
Management of Anaphylaxis in Mastocytosis
16:45 Coffee Break
Program Friday, October 9
8:10 Welcome Coffee
Session III: Presentation of ECNM Registry Projects
Chairs: P. Valent & W.R. Sperr
8:30 Wolfgang R. Sperr (Vienna, Austria)
Introduction and Presentation of Pilot Project:
IPSS for mastocytosis
8:40 Anja Rabenhorst & Karin Hartmann (Lübeck, Germany)
Age-Adjusted Diagnosis and Prognostication in Mastocytosis
8:50 Massimo Triggiani (Salerno, Italy)
Spectrum of Mediator-Related Symptoms in Mastocytosis
9:00 Hanneke Kluin-Nelemans (Groningen, Netherlands)
Clinical significance of blood count abnormalities in mastocytosis
9:10 Marek Niedoszytko & Boguslaw Nedoszytko (Gdansk, Poland)
Impact of allergic disorders and anaphylaxis in mastocytosis
9:20 Andreas Reiter & Juliana Schwaab (Mannheim, Germany)
Impact of serum chemistry on diagnosis and treatment of
systemic mastocytosis
9:30 Serena Merante (Pavia, Italy)
Treatment of patients with mastocytosis: comparison of
response rates
9:40 David Fuchs & Rosemarie Greul (Linz, Austria)
Risk of SM in patients with MIS
9:50 Roberta Zanotti & Patrizia Bonadonna (Verona, Italy)
Impact of bone marrow mastocytosis (BMM)
10:00 Nadja Jäkel (Leipzig, Germany)
Clinical impact of serum tryptase levels in the FU in SM
10:10 Elisabeth Aberer (Graz, Austria)
Skin lesion in different categories of mastocytosis
10:20 General open discussion of individual projects
Session V: Hot Topics in Mastocytosis
Chairs: J. Gotlib & K. Brockow
14:00 Joanna Renke & Magdalena Lange (Gdansk, Poland)
Antibody deficiencies in children with mastocytosis –
a new face of the disease?
14:15 Jaap J. Doormaal (Groningen, Netherlands)
Diagnosis and Management of Osteopathy in Mastocytosis
14:30 Michel Arock (Paris, France)
KIT Mutation Analysis: Proposed Standards and Algorithm of
the ECNM
14:45 Olivier Hermine (Paris, France)
Mental and Psychiatric Problems in Mastocytosis: Diagnosis
and Management
15:00 Almundena Matito (Salamanca, Spain)
Familial Mastocytosis and Management of Mastocytosis in
Pregnancy
15:15 Melody Carter (Bethesda, MD, USA)
tba
15:30 Coffee Break
Session IV: Pathology
Chairs: H. Kreipe & H.-P. Horny
11:30 Dan Arber (Stanford, USA)
Myeloid neoplasms: News from the WHO classification system
12:00 Hans Kreipe (Hannover, Germany)
Eosinophils and Mast Cells in the Neoplastic Bone Marrow
12:15 Sigrid Regauer (Graz, Austria)
Mast cells in pain disorders (vulvodynia, chronic bladder pain)
and in lichen planus
12:30 Hans-Peter Horny (Munich, Germany)
Unusual Cases: Mimickers and Chameleons in SM
Session VI: Basic Science and Cell Research
Chairs: A. Reiter & M. Triggiani
16:00 Animesh Pardanani (Rochester, MN, USA)
Mastocytosis research update from Mayo Clinic
16:15 Harald Bartsch (Munich, Germany)
MicroRNA expression profiles in mastocytosis
16:30 Thomas K. Kristensen (Odense, Denmark)
Targeted ultra-deep next generation sequencing as a method for
KIT mutation analysis in mastocytosis
16:45 Andreas Reiter (Mannheim, Germany)
Mutational Profiles of CFU-GM in various Categories of SM
17:00 Gunnar Nilsson (Stockholm, Sweden)
Mast cells and mediators in mastocytosis
17:15 Michael Huber (Aachen, Germany)
Positive and Negative Control of IgE-dependent MC Activation
17:30 Ivan Alvarez-Twose (Toledo, Spain)
Diagnosis and classification of well-differentiated
systemic mastocytosis
17:45 Olivier Hermine (Paris, France)
Masitinib for the treatment of severe systemic mastocytosis:
Pooled phase 2 study simulation of phase 3 population and
response criteria
18:00 Stéphane Barete (Paris, France)
Treatment with Cladribine (2-CdA) in adult patients with
mastocytosis
12:45 Lunch Break
20:00 Dinner (Der Pschorr, Viktualienmarkt)
10:30 Coffee Break
10:30- Registry Steering Committee Meeting (closed)
10:50 Discussion and Nomination of ECNM Registry Projects (closed)
Program Saturday, October 10
8:15
Welcome Coffee
Session VII: Proposed Clinical Studies: New Trials and Updates
Chairs: L. Escribano & K. Hartmann
8:30 Frank Siebenhaar (Berlin, Germany)
Clinical Trials to Control Mediator-Related Symptoms
8:45 Bernd Jilma (Vienna, Austria)
Proposed DAO Trial in Patients with SMSY
9:00 Serena Merante (Pavia, Italy)
JAK2-Inhibitors in Mastocytosis
9:15 Bjorn van Anrooij (Groningen, Netherlands)
Clinical Trials with PKC412 in ISM
9:30 Jason Gotlib (Stanford, CA, USA)
Update of PKC412 Trials in Advanced SM and MCL
9:45 Sigurd Broesby Olson (Odense, Denmark)
Targeted Approaches to control IgE-dependent
Reactions in Mastocytosis
Session IX: Late Breaking Abstracts
Chairs: M. Arock & K. Sotlar
12:30 Vito Sabato (Antwerpen, Belgium)
Update of Familial Hypertryptasemia
12:45 Selim Yavuz (Istanbul, Turkey)
Chronic Mast Cell Leukemia
13:00 Martin Zenke (Aachen, Germany)
Induced Pluripotent Stem Cells (iPSC) for Disease Modeling
in SM
13:15 Deepti Radia (London, U.K.)
Management of Patients with Mastocytosis in the U.K.
13:30 Judit Varkonyi (Budapest, Hungary)
Neoplastic and non-neoplastic comorbidities in systemic
mastocytosis
13:45 Francesca Levi-Schaffer (Jerusalem, Israel)
Mast Cell-Eosinophil Interactions in Health and Disease
14:00 Mariana Castells (Boston, MA, USA)
Drug Reactions in Mastocytosis: Is Pretesting useful?
10:00 Coffee Break
14:15 Closing Remarks and Announcements
Session VIII: Proposed Basic Science and Translational Projects
Chairs: G. Nilsson & K. Sotlar
10:30 Olivier Hermine (Paris, France)
ECNM Application Proposal: Horizon 2020
10:45 Carlo Pucillo (Udine, Italy)
MANTRA: Presentation of Concept
11:00 Celalettin Ustun (Minneapolis, MN, USA)
Occult Mastocytosis and KIT D816V in CBF AML
11:15 Frank Siebenhaar (Berlin, Germany)
EMBRN and other Basic Science Networks in the EU
11:30 Peter Valent (Vienna, Austria)
Presentation of a Basic Science Network-Section of the ECNM
11:45 General Discussion
12:00 Coffee Break
14:30 End of Meeting