#24926 HAAO A Antibod

#24926
HAAO Antibod
A
dy
Size:
100μg
Orders: order@signa
alwayantibody
y.com
Concentratio
on:
1mg/m
ml
Support: tech@signa
alwayantibody.com
Storage:
-20℃ one year
Web: ww
ww.signalway
yantibody.com
m
T
Tested
Applic
cation
Species Rea
activity
Ho
ost
E, WB, IH
HC
H, M, R
Rab
bbit
Molec
cular Wt.
B
Background
: HAAO (3-H
Hydroxyanthrranilate 3, 4--dioxygenase
e) is a mono
omeric cytoso
olic protein of
o the family of
in
ntramolecular dioxygenasses containin
ng non-heme
e ferrous iron
n. It is widelyy distributed in periphera
al organs, succh
as liver and kidney,
k
and is present in
n low amoun
nts in the cen
ntral nervouss system. Th
his enzyme participates in
ne cofactor, iron. HAAO catalyzes th
he synthesiss of quinolinic acid (QUIN
N)
trryptophan metabolism. Itt employs on
frrom 3-hydroxyanthranilicc acid. QUIN
N is an exccitotoxin who
ose toxicity is mediated
d by its ability to activa
ate
glutamate N-methyl-D-asspartate recceptors. Inccreased cerebral levelss of QUIN may partic
cipate in th
he
ammatory dissorders. HAA
AO has been
n suggested to play a role in disorde
ers
pathogenesis of neurological and infla
w
altered tissue levelss of QUIN. Furthermore
e, recent study shows that HAAO are excelle
ent
associated with
andidate biomarkers for detecting ovarian cancerr.
ca
P
Purification:
Affinity chromatography purified via peptide column
Im
mmunogen: 17 amino accid peptide near
n
the amin
no terminus of human HA
AAO.
A
Application：
HAAO antib
body can be used for dettection of HA
AAO by Westtern blot at 1 - 2 ug/mL.
S
Synonyms:
3
3-hydroxyant
thranilate 3, 4-dioxygena
ase, 3-hydrox
xyanthranilate oxygenase
e, 3-HAO, HA
AD, HAO
P
Protein_GI_N
No.：188497
7625
P
Protein_Acce
ession_No.::NP_036337
7
R
Reference：
D
Decker
RH, Kang
K
HH, Le
each FR, et al.
a Purificatio
on and prope
erties of 3-hyydroxyanthra
anilic acid ox
xidase. J. Bio
ol.
C
Chem.1961;
2
236:3076-82
.
H
Huang
YW, Jansen
J
RA, Fabbri E, et
e al. Identificcation of candidate epig
genetic biom
markers for ovarian
o
canccer
detection. Oncol. Rep.200
09; 22:853-61.
W
Western
blot analysis of HAAO in Mouse
M
liver tiissue
Immu
unohistochem
mistry of HA
AAO in huma
an liver tissu
ue
lyysate with HA
AAO antibody at 1 ug/mL
L.
with HAAO antibo
ody at 2.5 ug
g/mL.
s know.
Iff you publish research ussing #24926,please let us
This produc
ct is for in vitro
o research use only and is no
ot intended for use in humans
s or animals.