Document 6533789

August 10, 2007
To:
Primary Care Physicians and Clinicians
From:
XXX on behalf of the Upper Midwest Fistula First Coalition
RE:
Chronic Kidney Disease (CKD) Resources
Caring for patients with chronic kidney disease (CKD) is a great challenge for both
primary care providers and nephrologists. This challenge increases when patients do
not receive a timely referral to a nephrologist . This delayed referral leads to
emergency dialysis with higher morbidity, mortality and excessive cost. Emergency
dialysis limits the dialysis modality choice, endangers the ability to place a permanent
vascular access prior to dialysis initiation, precludes psychological preparation of
patients and family, and frequently necessitates hospitalization for a catastrophic
complex illness.
Early referral of chronic kidney disease patients offers many advantages. In addition
to beginning the process of education and preparation for renal replacement therapy,
benefits include:
• A diligent search may reveal a potentially reversible cause of renal failure.
• A number of measures may be implemented to preserve the remaining renal
function, e.g., good control of blood pressure, glucose control in diabetics,
nutritional guidance, and avoidance of nephrotoxic drugs.
• Upper extremity vessels may be preserved for placement of a native arteriovenous
fistula, the most reliable type of vascular access.
• Treatment of anemia with erythropoietin may significantly improve life quality.
• Secondary hyperthyroidism may be treated with phosphate binders and calcitriol.
• Referral to a team consisting of a nephrologist, renal dietitian, dialysis nurse, social
worker and financial counselor allows time to establish the best treatment
modality for the patient, develop financial support if needed and to allay the fears
of both patient and family.
In order to assist you in identifying and treating chronic kidney disease in your
patients, we are providing you two resources to use within your practice. The first
resource is a pocket guide developed by the National Kidney Disease Outcomes
Quality Initiative (KDOQI) of the National Kidney Foundation (NKF) and includes the
Clinical Action Plan to assist you in developing an individualized CKD plan of care for
your patients, and Clinical Interventions for Adults that will provide a summary of
recommended interventions for patients with complications associated with CKD.
The second resource is a wall chart that displays two algorithms, a CKD assessment
algorithm that will assist you in identifying patients as having CKD, and a treatment
algorithm that will assist you in developing a treatment plan for patients with CKD.
These resources are also available to download electronically at
www.esrdnet11.org/coalition.
We hope you will find this a useful tool in working with your patients who may need
treatment or referral for their kidney disease. If you have any questions please feel free
to contact YYY at XXX-XXX-XXXX.
GFR CALCULATION
Adapted from the National Kidney Foundation. KDOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification and Stratification. AM J Kidney Dis 39,
2002 (suppl 1).
Or visit the National Kidney Foundation website to use calculator: http://www.kidney.org/professionals/kdoqi/gfr_calculator.cfm
To calculate GFR, the MDRD Formula can be used for adults: Estimated GFR (mL/min/1.73 m2) =
186 × (SCr ) -1.154 × (Age) -0.203 × (0.742 if female) × (1.21 if African American)
Adapted from the National Kidney Foundation. KDOQI Clinical Practice Guidelines for Chronic Kidney
Disease: Evaluation, Classification and Stratification. AM J Kidney Dis 39, 2002 (suppl 1)
Distributed with permission by the
Upper Midwest Fistula First Coalition
CKD Assessment Algorithm
Identification, Treatment, and Referral
Patient
Office
Visit
Is patient at risk for CKD?
Susceptability
-Age > 60 years
-Family history of CKD
Direct Risk Factors
-Diabetes
-Systemic infections
-High blood pressure
-Urinary tract infection
-Autoimmune diseases
-Urinary stones
-Lower urin tract obstruction -Drug toxicity
-Hx acute renal failure
-Exposure drugs/procedures
Progressive Risk Factors
-High levels proteinuria
-Malignant hypertension
-Poor glycemic control
-Smoking
No
STOP
Change Concept 1
Yes
Perform routine screening for CKD for patients at increased risk
*Serum creatnine to determine estimated GFR
*Assessment of proteinuria
*Urinalysis for presence of white & red blood cells
Change Concept 2
Yes
Does patient have
abnormal GFR > 3 months?
Determine
Stage of
CKD
No
Does patient have protein to
creatinine ratio > 1.0 gm?
No
Yes
Follow Up CKD Monitoring
Stage 1
Stage 2
Stage 3
Stage 4
Stage 5
GFR > 90
P:C > 1.0 x 2
GFR 60-89
GFR 30-59
GFR 15-29
GFR < 15
-Test patients at risk for CKD annually
-Counsel patients at risk for CKD but found not to have
CKD to reduce risk factors when possible.
Begin CKD Treatment: Develop Clinical Action Plan
Identify risks associated with CKD
Collaborate with nephrologist to develop action plan to include:
*Evaluate and manage comorbid conditions (Primary care, all stages)
*Slow the loss of kidney function (Co-management, all stages)
*Prevent & treat cardiovascular disease (Primary care, all stages)
*Prevent & treat complications of decreased kidney function (Co-management, all stages)
*Prepare for kidney failure and replacement therapy (Nephrology, stage 4)
*Replace kidney function (Nephrology, stage 5)
Consult nephrology if action plan cannot be performed or carried out or when GFR < 60
*Evaluate type of kidney disease
*Evaluate complications of kidney disease: anemia,
hypertension, malnutrition, bone disease, metabolic
acidosis, congestive heart failure, hyperkalemia, edema
determined to fluid overload, neuropathy
*Evaluate risk for loss of kidney function
*Evaluate comoribid conditions
*Evaluate risk for cardiovascular disease
Change Concept 3
Change Concept 4
Assess barriers to treatment adherence
Review medication usage at follow-up visits
*Family and social support
*Depression
*Income & unemployment concerns
*Stress and coping mechanisms
*Perceptions of illness & treatment
*Limited access to medications and/or care
*Evaluate for necessary dose adjustments based on level of kidney function
*Evaluate for adverse effects of medications on kidney function (NSAIDs, IV contrast)
*Evaluate for drug interactions
*Counsel patient to avoid nephrotoxic drugs and IV contrast
*Evaluate appropriateness for ARB/ACE inhibitor with diagnosis of hypertension
*Evaluate need for therapeutic drug monitoring
Change Concept 6
Change Concept 5
Consult/Refer to Nephrologist
Monitor
CKD
Progression
No
Does patient have
GFR < 60 for > 3 months
or proteinuria > 3 gm?
Yes
*Consult nephrologist at Stage 1 if hematuris or significant proteinuria present
*Consult nephrologist at Stage 2 if GFR declines > 4mL/min/yr
*Consult nephrologist at Stage 3 for al patients with CKD
*Refer patient to nephrologist for evaluation when GFR < 30 mL/min/1.732
Change Concept 7
CKD Treatment Algorithm
CKD Stage 1
CKD Stage 2
CKD Stage 3
CKD Stage 4
CKD Stage 5
GFR 60 - 89
mL/min/1.73 m2
GFR 30 - 59
mL/min/1.73 m2
GFR 15 - 29
mL/min/1.73 m2
GFR < 15
mL/min/1.73 m2
PRIMARY CARE
Assess Complications
PRIMARY CARE
Assess Complications
CO-MANAGEMENT
Assess Complications
NEPHROLOGY
Assess Complications
NEPHROLOGY
Assess Complications
LABS
BP monitoring q 6 mo.
GFR q 12 mo.
Urinalysis q 12 mo. to assess
hematuria, proteinuria,
microalbuminuria
Lipids q 12 mo.
If diabetic, Hgb A1C and
microalbuminuria q 12 mo.
LABS
BP monitoring q 3-12 mo.
GFR q 12 mo.
Urinalysis q 3 -12 mo. to
assess hematuria,
proteinuria, microalbuminuria
Lipids q 12 mo
If diabetic, Hgb A1C and
microalbuminuria q 12 mo.
Hgb q 12 mo. if > 11 gm/dL
GFR > 90
mL/min/1.73 m2
P:C ratio > 1.0 gm protein/gm
creatinine x 2
RISK ASSESSMENT
Avoidance of nephrotoxic
agents & dyes
Immunizations
-Flu vaccine q 12 mo.
-Pneumovax, as indicated
-Hep B vaccine, as indicated
Assess cardiovascular risk:
- Smoking cessation
- Physical activity
EDUCATION
Cardiovascular risk
Medications to avoid
Immunizations
RISK ASSESSMENT
Avoidance of nephrotoxic
agents & dyes
Immunizations
-Flu vaccine q 12 mo.
-Pneumovax, as indicated
-Hep B vaccine, as indicated
Assess cardiovascular risk:
- Smoking cessation
- Physical activity
EDUCATION
Cardiovascular risk
Medications to avoid
Immunizations
LABS
BP monitoring q 3-12 mo.
GFR q 3-12 mo.
Urinalysis q 6-12 mon. to assess
hematuria, proteinuria,
microalbuminuria
Lipids q 2 mo
If diabetic, Hgb A1C and
microalbuminuria q 12 mo.
Hgb > 11 q 3-6 mo.
Hgb < 11 q 1-3 mo.
Lytes and glucose q 12 mon.
PTH, Ca & P q 3-12 mo.
Measure 25(OH)D
RISK ASSESSMENT
Avoidance of nephrotoxic
agents & dyes
Immunizations
-Flu vaccine q 12 mo.
-Pneumovax, as indicated
-Hep B vaccine, as indicated
Assess cardiovascular risk:
- Smoking cessation
- Physical activity
EDUCATION
Cardiovascular risk
Medications to avoid
Immunizations
Nutrition: Advise diet low in
salt & potassium
Renal bone disease
Distributed by the Upper Midwest
Fistula First Coalition
The Kidney Disease Outcomes Quality Initiative (KDOQI) recommendations for
Chronic Kidney Disease: Evaluation, Classification, and Stratification were
used to develop portions of these documents.
LABS
BP monitoring q 3-6 mo.
GFR q 3-6 mo.
Lipids q 12 mo.
If diabetic, Hgb A1C and
microalbuminuria q 12 mo.
Hgb q 3-6 mo., monthly if on
ESA therapy
PTH, Ca, P. q 3-6 mo.
Measure 25(OH)D
RISK ASSESSMENT
Avoidance of nephrotoxic
agents & dyes
Immunizations
-Flu vaccine q 12 mo.
-Pneumovax, as indicated
-Hep B vaccine, as indicated
Assess cardiovascular risk:
- Smoking cessation
- Physical activity
EDUCATION
Cardiovascular risk
Medications to avoid
Immunizations
Nutrition: Advise diet low in
salt, phos. & potassium
Renal bone disease
Anemia
Vascular access placement
Modality options
REFERRALS
Surgeon for vascular access
placement
Transplant center for eval
LABS
GFR q 1-3 mo.
Lipids q 12 mo.
If diabetic, Hgb A1C and
microalbuminuria q 12 mo.
Hgb monthly
PTH, Ca, P q 1-3 mo.
Measure 25(OH)D
HBV titer
RISK ASSESSMENT
Avoidance of nephrotoxic
agents & dyes
Immunizations
-Flu vaccine q 12 mo.
-Pneumovax, as indicated
-Hep B vaccine, as indicated
Assess cardiovascular risk:
- Smoking cessation
- Physical activity
EDUCATION
Cardiovascular risk
Medications to avoid
Immunizations
Nutrition: Advise diet low in
fluids, salt, phos. &
potassium
Renal bone disease
Anemia
Vascular access monitoring
Modality options
Evaluation for kidney
transplant
REFERRALS
Surgeon for vascular access
intervention, as needed
Transplant center for eval