A journey into the world of taste: medicine, nutrition and
Transcription
A journey into the world of taste: medicine, nutrition and
DIPLOME D’UNIVERSITE DU GOUT, DE LA GASTRONOMIE ET DES ARTS DE LA TABLE DUGGAT MÉMOIRE DE FIN D’ÉTUDE A journey into the world JUIN 2009 of taste: medicine, nutrition and gastronomy side by side in health, disease and hedonism Maria Isabel Toulson Davisson Correia 1 AKNOWLEDGMENTS - To all that have been part of this project, this is to say, the group of Hautes Études du Goût 2008: organizers, teachers and classmates who were so much fun, great company, and above all great friends throughout the two intense weeks spent together in Paris and Reims. You will be forever part of my life! - To my three men, Mário, Marco Túlio and Gustavo, who so patiently live through all my adventures and endeavors, always figuring out what it is going to come next…….you never know! - To my parents for the blessing of my existence! - To God, Buddha, Allah and all divinities for life…. so good and so intense! “True religion is real living; living with all one's soul, with all one's goodness and righteousness.” Albert Einstein, 1879 - 1955 2 SUMMARY LIST OF FIGURES.......................................................................................... 4 ABSTRACT ..................................................................................................... 5 1. REVIEW OF THE LITERATURE ................................................................ 6 1.1. TASTE .................................................................................................. 7 1.2. MEDICINE .......................................................................................... 12 1.2.1. Art ................................................................................................. 12 1.2.2. Science......................................................................................... 13 1.3. NUTRITION ........................................................................................ 16 1.3.1 Essential to life ............................................................................. 16 1.3.2. Science......................................................................................... 17 1.4. GASTRONOMY................................................................................. 20 1.4.1 Science......................................................................................... 20 1.4.2. Art ................................................................................................. 31 1.5. HEALTH AND DISEASE.................................................................... 34 1.5.1. Eating habits................................................................................ 36 1.5.2. Commensality.............................................................................. 38 1.5.3. Learning attitudes ........................................................................ 41 1.5.4. Disease........................................................................................ 43 1.5.5. Molecular gastronomy ................................................................. 48 2. CONCLUSION .................................................................................... 54 3. FUTURE PERSPECTIVES ................................................................. 56 4. REFERENCES.................................................................................... 58 3 LIST OF FIGURES Figure 1. Anatomy of the tongue (papillae and nerves) …………………..…08 Figure 2. Montages of a tongue tip of a non-taster versus a taster ……..….11 Figure 3. Hippocrates oath .........................................................................16 Figure 4. Portrait of Yvan Mei .....................................................................23 Figure 5. Carême’s drawing of the hermitage russe ...……………..………..32 Figure 6. Feeding the sick ………………………………………………………34 Figure 7. The map of hunger …………………………………………………...38 Figure 8. Enhancing recovery after surgery …………………………………..45 Figure 9. Food chain in the hospital setting …………………………………..47 Figure 10. Forbidden to forbid ………………………………………………….48 Figure 11. Be healthy ………………………………...………………………….52 4 ABSTRACT Every time something is placed in somebody’s mouth one or a combination of tastes alerts to vital information about that matter. This might justify why Romantic gastronomers, self proclaimed professors of taste, considered the profoundly physical pleasures of the palate to be the pinnacle of aesthetic appreciation. No wonder why food, as approached by gastronomy, was elevated during the nineteenth century to the status of fine arts. However, food should also be seen as science because it has, throughout the centuries, been the subject of many studies which have assessed its role in the prevention and treatment of several disease states, not to talk of its social role. In this sense, Medicine, directly associated with the existence of human kind, should similarly be regarded as art and science, where food, taste and pleasure are intertwined both in health and disease. To support the relevant association of all these arts and sciences, more recently chemistry in the form of molecular gastronomy has been added to the roll, presenting its fascinating approach on food phenomena and as an alternative to be offered to certain disease states and culinary experiences. It is thus the purpose of the current review to invite people to delve into the wonderful journey of taste, medicine, nutrition and gastronomy placed side by side in health, disease and hedonism. Key-Words: taste, medicine, nutrition, diet, gastronomy, molecular gastronomy, health, disease. 5 1. REVIEW OF THE LITERATURE “When we no longer have good cooking in the world, we will have no literature, nor high and sharp intelligence, nor friendly gathering, nor social harmony.” Antonin Caréme, 1766 - 1823 6 1.1. TASTE “The senses are the organs by which man places himself in connection with exterior objects.” Brillat Savarin, 1755 - 1826 Every time something is placed in somebody’s mouth one or a combination of tastes alerts to vital information about that matter. If it's sweet, maybe it's got the nutrients the body needs to keep running for another few hours. If it's salty, perhaps it is necessary to replace some of those vital minerals just excreted through sweat or urine. If it's sour, there's a chance it's not ripe and will cause a bad bellyache. If it's bitter, watch out….. it could be poison and the next swallow will be the last. Thus, eating is associated to neurophyscological inherited and acquired phenomena. Deciding what tastes "good" is anything but simple. A food's flavor doesn't usually depend on data from a single sense1. Rather, smell, touch, sight and even hearing often come into play, and the best methods of pleasurably exciting those senses, during a meal or snack, occupies the days of thousands of chefs, brewers, marketing flaks, and scientists around the world. Senses depend on an intricate cross talk between the different sensitive areas enervated by peripheral nerve branches and the remaining nervous system, medulla and brain1, 2. This is a complex system yet not fully known which has demanded scientists to delve deeply into its mechanisms2. In terms of taste, until very recently, a concept that has guided much taste research is the existence of only four (or possibly five) independent taste qualities. These four so-called basic” or “primary” tastes are sweet, sour, salty, and bitter; a fifth quality, the taste of glutamate salts called “umami,” has also been described1-3. All other tastes are presumed to be combinations of these basic tastes mixed in various proportions. The idea that taste was, as the other senses, just a mechanical action in which 7 nervous fibers played the conductors to reach the brain has also been rejected. A new concept has emerged showing that aside from the receptor, this has to interact with a chemical signal or “a tastant”4. Tastants are chemicals that stimulate receptors and ion channels in taste receptor cells found in taste buds ( garlic clove-like structures). The latter are contained within papillae on the tongue’s surface in the soft palate, pharynx, larynx, and epiglottis.. Papillae types vary according to the region in the tongue. For example, in the anterior area of the tongue fungiform papillae predominate, foliate papillae are located in the posterior lateral sides of the tongue and circumvallate (rearward facing chevron across the back of the tongue) papillae (Figure 1 ). Figure 1 - Anatomy of the tongue (papillae and nerves) 1 Taste buds contain between 50 and 150 cells that form a discrete ovoid structure2. These cells are divided into basal cells (from which new taste cells originate) as well as elongated cells, some of which have microvilli that extend through a taste pore into the oral environment. Tastants dissolve in saliva and cross a mucus layer to reach microvilli and taste receptors. Diminished salivary production can impair taste perception and this explains why elderly people who, in general, have less saliva present with taste 8 disorders, as well as those individuals who have undergone chemo or radiotherapy. The tastants then activate either ion channels (sour, salty) or G protein (gustucin) coupled receptors (sweet, bitter, umami), depolarizing these cells. These, in turn, set up impulses in the taste nerves. It is interesting to note that the pleasure response to sweetness and disgust from bitterness is present at birth and not learned. Response to saltiness develops during the first year of life2, 3. Branches of three cranial nerves innervate taste buds, transmitting the electrical impulses to the medulla: the chorda tympani nerve innervates fungiform and anterior foliate papillae and the lingual nerve innervates the posterior foliate and circumvallate papillae. Taste buds on the soft palate are innervated by the superficial petrosal nerve, while those on the epiglottis are innervated by the superior branch of the vagus nerve. Each nerve has fibers that respond best to a specific taste quality1. However, the tongue map – the idea that certain areas respond only to certain taste qualities – is wrong; all areas of the tongue respond to all qualities3. From the medulla, the taste impulses reach the brain, more precisely the primary taste cortex in the rostal insula and adjoining frontal operculum and the orbitofrontal cortex that contains the secondary taste cortex, in which the reward value of taste is represented. The latter area also contains the secondary and tertiary olfactory cortical areas, in which information about the identity and also about the reward value of odors is represented. The orbitofrontal cortex also receives information about the sight of objects from the temporal lobe cortical visual areas, and neurons in it learn and reverse the visual stimulus to which they respond when the association of the visual stimulus with a primary reinforcing stimulus (such as taste) is reversed. Foods and beverages stimulate multiple fibers in the trigeminal nerve (CN V): tactile sensations such as particle size, texture and creaminess stimulate mechanoreceptors while temperature triggers thermoreceptors and, irritants and pungent foods stimulate nociceptors. Somatosensory input is tightly integrated with, but separate from, smell and taste input. 9 Hedonic responses to odorants are learned through positive (e.g. pairing odors with energy, repetitive exposure) and negative (i.e. flavor aversions) conditioning. Odors reach the olfactory epithelium via the nares passively through breathing and actively through sniffing and via the mouth and nasopharynx actively through chewing and swallowing. Retronasal olfaction is as important as oral sensation, however they play different roles5. For example, cheese that is aversive when sniffed is enjoyed when eaten. Within the mouth, amino acids and salt stimulate the taste system and fat stimulates somatosensation. Chewing warms the cheese and releases volatiles. When swallowed, the latter creates a pressure differential that pumps cheese volatiles through the oropharynx and nasopharynx to the olfactory epithelium. The way a person eats impacts on his/her taste perception and an example is slowing the rate which allows time to savor the flavor. The blending of taste, somatosensory and retronasal experiences promotes satiation6. All these sensations are transmitted to the brain where the odor message is compared with a template of past experiences and is enjoyed or not according to them. Thus, the integration of peripheral inputs occurs centrally. Elderly and sick people lack some of these capacities and genetics definitely interfere in each person’s individual capacity of taste. This explains why some people become experts in chocolate or coffee tasting etc1, 3, 4, 6 . Compared with nontasters, supertasters taste sweet, sour, salty and bitter compounds more intensely, as well as perceive more chemesthetic sensations from chili peppers, black pepper, ginger, carbonation, and alcohol. Supertasters also experience heightened tactile sensations from high-fat milk products, salad dressings and greater intensities from 1 retronasal stimuli . (Fig 2). 10 Food preferences and dietary behaviors seem to be related to variation in taste, smell and oral somatosensation. These, on the other hand, depend on complex genetic-environmental interactions. All of them are extremely important to man’s perception of food and a link between physical and psychological approaches. In common parlance, moral transgressions “leave a bad taste in the mouth.” This metaphor implies a link between moral disgust and more primitive forms of disgust related to toxicity and disease. Some authors have tested directly the primitive oral origins of moral disgust by searching for similarity in the facial motor activity evoked by gustatory distaste (elicited by unpleasant tastes), basic disgust (elicited by photographs of contaminants), and moral disgust (elicited by unfair treatment in an economic game). They found that all three states evoked activation of the levator labii muscle region of the face, characteristic of an oralnasal rejection response. These results suggest that immorality elicits the same disgust as disease vectors and bad tastes7. Taste is directly related to nutrition and diets. It impacts brain function across the lifespan. The importance of specific nutrients for brain function, cognitive and mental health, and susceptibility and resistance to brain dysfunction, as well as many other health and disease states is just beginning to be explored. Also taste has a direct role in hedonic behavior. Romantic gastronomers, self proclaimed professors of taste, considered the profoundly physical pleasures of the palate to be the pinnacle of aesthetic appreciation. Food was elevated during the nineteenth century to the status of fine arts, adopting the same juridical language and concern with philosophical principles that defined the eighteenth century discourse of aesthetics8. Nonetheless, taste has always been ranked low on the philosophical hierarchy of the senses as a means to ingress to the mind. Whereas sight and hearing allow for a proper representative distance from the object of contemplation, taste like its closest cousin smell, is bound up with the chemical physiology of the body. While the exertion of the higher senses theoretically leads to more mind, the exercise of the lower senses of taste and smell can result in too much body and its various forms of 11 sensuousness: to indulge the most basic human appetites is to risk becoming a glutton, a drunkard or a voluptuary. Thus, a journey into the world of taste justifies why medicine, nutrition and gastronomy are side by side in health, disease and hedonism. 1.2. MEDICINE “The practice of medicine is an art, not a trade; a calling, not a business; a calling in which your heart will be exercised equally with your head. Often the best part of your work will have nothing to do with potions and powders, but with the exercise of an influence of the strong upon the weak, of the righteous upon the wicked, of the wise upon the foolish.” William Osler, 1849 - 1919 1.2.1. Art Art is the subtle or imaginative ability in inventing, devising, or executing something9. And what does Medicine have to do with art? First, they share a common goal: to complete what nature has not. Second, they have a common substrate, the physical, visible world of matter. More significant, however, are the similar qualities of mind, body, and spirit demanded of the practitioners of each, artist and physician. Chief among them is an eye: the ability not only to observe, but to observe keenly -- to ferret out the tiny detail from the jumble of facts, lines, colors -- the tiny detail that unlocks a painting or a patient's predicament. Observation demands attention, and this is the key to both art and medicine. Attention is nothing more than a state of receptiveness toward its object, the artist to nature, the viewer to the work of art, the physician to the patient. It is no accident, I believe, that clinicians -- or treating physicians, as they are often called -- are referred to as "attending physicians." "Attention" and "attend" are both derived from the same Latin root meaning "to stretch toward." Many more "affinities" exist between medicine and the visual arts, but I will close with just one: Medicine is itself an art. It is an art of doing, and if that is so, it must employ the finest tools available -- not just the finest in science and 12 technology, but the finest in the knowledge, skills, and character of the physician. Truly, medicine, like art, is a calling10. 1.2.2. Science Medicine has also to be science because its role has been beyond comforting and curing the sick ones. More recently, a key aspect of Medicine has been to prevent the outbreak of diseases. In order to perform such, it has been fundamental do investigate hypothesis, to develop theories, to spend times in the laboratories and search for better diagnosing tools and treatments, plus creating vaccines. Even before there were humans on earth, there was disease. Studies of animal fossils have shown that prehistoric creatures were subject to manifold diseases and injuries. Fossil teeth with erosions, pyorrhea, as well as cavities were identified. abscess and Investigations of human remnants from different historic periods have uncovered many disease entities such as tuberculosis, bone fractures and parasitic infections. The mummies in Egypt show characteristics of tubercular disease of the spine, pneumonia, stones, parasites, urinary infections and even arteriosclerosis. Ancient bones in the Americas have shown that preColumbian syphilis or a different spirochetal disease was a reality. Bone wasting (osteomalacia) has been interpreted as a sign of poor nutrition in ancient times, although rickets was rare, maybe due to great light exposition. The healing process has also been part of man’s instinct maybe much similar to how sick animals treat themselves. In the first century of Christian Era, Pliny repeated the tall tale about the hippopotamus which when ill would plunge its knee into a sharp reed to let out blood and heal itself11. The principle of bloodletting so much adopted in human Medicine not until long ago. Also, animals when hurt apply mud to their wounds and plunge into cold water to relieve discomfort. Men on the other hand rub wounds using thus heat to ameliorate inflammation and apply cold to deaden pain, principles much identical to the ones used by animals. 13 Apparently primitive societies were subject to many of the same diseases which still afflict humans today if we were to judge by the multiplicity of ailments under the care of specializes shamans. These included stomach upsets, diarrheal diseases, respiratory illnesses, rheumatic ailments and menstrual disorders. However, with the evolution of times, other diseases were added to this list and obesity is nowadays the biggest epidemic worldwide. Disease has affected men and women differently. All throughout times, men seemed to have lived longer than women, the common assumption being that pregnancy and childbirth were responsible for the difference. However, even if this were true it would only justify life expectancy for the younger ones and not the overall community. Nutrition, on the other hand, maybe the explanation for this phenomenon, since chronic malnutrition, starting in infancy and continuing through childhood and adulthood made women less resistant to illness. According to this theory, men and boys, as leaders, hunters and warriors, were considerably better fed than women and girls who were the home laborers, crop cultivators and child bearers. No matter which diseases have afflicted humankind, food has always been linked to many of them, be either related to deficiencies such as malnutrition or excess as obesity12. Many medical bases for food prohibitions have had their principles not only on religious principles but also on social and anthropological reasoning. In Nei Ching, or The emperor's book of internal medicine, written by the Yellow Emperor, sometime in 3.000BC, there are three kinds of medicines: the lowest is poisonous, the middle is a little poisonous and the highest is not poisonous. The lowest cures six out of every 10 diseases and leaves poison in the body. The middle cures seven of every 10 diseases and leaves a little poison in the body. Even the highest cures only nine to ten of every 10 diseases. Diseases that cannot be cured with Medicine, can be cured only with food13. 14 Medicine, as practiced nowadays, owes much to Hippocrates, the first world known, reputed physician and teacher at the famous medical school on the Mediterranean island of Cos. Hippocrates is generally credited with turning away from divine notions of Medicine and using observation of the body as a basis for medical knowledge. Prayers and sacrifices to the gods did not hold a central place in his theories, but changes in diet, beneficial drugs, and keeping the body "in balance" were the key. Central to his physiology and ideas on illness was the humoral theory of health, whereby the four bodily fluids, or humors, of blood, phlegm, yellow bile, and black bile needed to be kept in balance. Illness was caused when these fluids became out of balance, sometimes requiring the reduction in the body of a humor through bloodletting or purging. The Hippocratic Corpus, or the collected writings attributed to Hippocrates, contains about sixty works on a variety of medical topics, including diagnosis, epidemics, obstetrics, pediatrics, surgery and nutrition. In his writings, Hippocrates introduced ethical concepts (Hippocrates Oath – fig. 3 ) which prevail till nowadays, by pointing to the importance of curing sometimes, treating frequently and comforting always. He acknowledged the importance of giving each individual just the right quantity of nutrition and exercise, not too little, not too much, but just enough to lead to healthy living habits. His famous quote “Let food be thy medicine and medicine be thy food" has certainly confirmed that health and disease are linked by one basic and essential determinant: Nutrition. 15 Figure 3 – Hippocrates Oath, available at http://wwwihm.nlm.nih.gov/ihm/images/A/24/222.jpg 1.3. NUTRITION “Our food should be our medicine and our medicine should be our food." Hippocrates, 460 BC – 370 BC 1.3.1 Essential to life Nutrition is essential to the survival of any living being. It plays a key role in man’s life by covering body requirements but also supporting social roles. Although some have tried to prove that life is possible without eating14, by just looking at the sun, evidences from hunger strikers have shown that among those who had lost 38% of the usual body weight , 33% died15. Healthy individuals when undergoing a fasting state presented with loss of 20% of total body proteins which equaled 15% of usual body weight loss. This led to muscle mass weakness and decreased respiratory function. Ten to twenty percent of these impairments were immediately recovered after five days of nutrition supplementation16. 16 Disease and nutritional status interact. The former might lead to disease while the latter worsens the disease per se and the patient’s overall clinical condition. Past pope John Paul II 17 (1920- 1985) stated at the inaugural conference of the International Conference of Nutrition, in Rome, 1992 that “Hunger and malnutrition are unacceptable in a world that has both the knowledge and the resources to end this human catastrophe”. He also pointed that “The Universal Declaration of Human Rights had already asserted the right to sufficient food. What we must now do is ensure that this right is applied and that everyone has access to food, food security, a healthy diet and nutrition education. In short, all people must be able to enjoy personal and community living conditions that allow them to realize their full human potential, at every point in their lives.” He finalized his speech by saying “This is why the Pope asks you, participants at the International Conference on Nutrition, to work for a world in which no one is denied his or her daily bread or health care.” 1.3.2. Science Nutrition sciences have long played a key role in humanity development both in community and hospital settings. Famines which have marked distinct eras throughout time, leading to the death of millions of people, have only been diminished due to strong efforts of various scientists. In the same line, hospital malnutrition to which many hospital complications and deaths have been attributed has been the focuses of several studies wordwide18-22. Cicely Williams first described kwashiorkor malnutrition in what is now Ghana in 193323. Her excellent publication was overlooked until J. Brock (World Health Organization; WHO) and M. Autret (FAO) toured Africa and reported to the second FAO/WHO Expert Committee in 1951 that the disease described by Williams was widespread throughout Africa. This was recognized as a condition common in Central America, also, where Scrimshaw 24 began to study intensively both kwashiorkor and marasmus 17 using one cot and one crib for six children on an overcrowded pediatric ward in the general hospital. With a nutritionist to supervise their food intake, the kwashiorkor children rapidly lost edema, skin lesions, anorexia, and apathy. However, they failed to gain weight for many more weeks. After, these children were later individually kept in a unit of six individual cubicles in a private pediatric hospital, never again there was a stationary period in the treatment of kwashiorkor. It was then realized that it was the adverse nutritional impact of multiple cross-infections in an open ward that prevented these children from gaining weight. Based on their recently found reports, this author together with a group of investigators developed the concept and patent of Incaparina a free use indigenous protein supplement to be freely used in any developing country24. Hospital malnutrition was assessed by the Brazilian National Survey on Hospital Nutritional Assessment (IBRANUTRI). This was a study designed to provide missing information regarding the nutrition status of hospitalized patients covered by the Brazilian public health care system (SUS). Specifically, the prevalence of malnutrition, awareness of nutrition status in hospitalized patients, and the use of nutrition therapy were assessed20. This study showed that almost 50% of hospitalized patients were malnourished. In a larger study in Latin America similar results were found18. Hospital malnutrition was significantly associated with complications, mortality, length of hospital stay and costs19. Eating habits and poor diets have also been linked to most major nutrition epidemics of the current world. Of these, obesity plays a key issue by increasing overall complications and death rates. The World Health Organization estimates that more than two billion people are overweight and this number has been plunging year after year25. Although, many people are convinced of the importance of food in both causing and relieving diseases, many doctors' knowledge of nutrition is still rudimentary. Most feel much more comfortable with drugs than foods, and the "food as medicine" philosophy of Hippocrates has been largely neglected. That may be about to change! Concern about obesity, as previously 18 mentioned, is rocketing up political agendas, and a growing interest in the science of foods is opening up many therapeutic possibilities. One example of this could be attributed to Lucy Wills, 1931, who described how yeast extract could be effective in preventing tropical macrocytic anaemia of late pregnancy26. Folate was shown to be the crucial factor. In the 1980s a series of studies showed how periconceptional folate could prevent spina bifida. Then, later meta-analysis studies have established that high homocysteine concentrations were a risk factor for atherosclerosis27. Dietary folate reduces homocysteine, raising the possibility that a vitamin might prevent vascular disease. Next, several nucleotide polymorphisms were found to be related to folate, meaning that folate levels might influence the chance of developing cancer264. These discoveries are not surprising as folate metabolism is involved in many of the fundamental processes of life. It is important for nucleotide biosynthesis. Thymidylate synthase, an enzyme that helps synthesize DNA, depends on a folate derivative. Low levels of folate may thus lead to breaks in DNA, predisposing to cancer. There are many other ways in which folate can affect gene function, and so folate is central to nutrigenomics—the study of the links between nutrition and gene function26. Folate may thus be a leading contender for panacea of the 21st century. Addition of folate to foods might reduce birth defects, vascular disease, and heart disease—and the Americans favour fortifying bread with folate. But folate being involved in so many of life's fundamental processes not only leads to its possibilities as a panacea but also to the prospect that "messing around with folate" could do extensive harm. The folate used in food fortification is not a natural co-enzyme, and nobody knows the long term effects of exposing whole populations to the unnatural folate. There is thus great potential for good, some possibility of harm, and much uncertainty. The question of fortifying foods inevitably becomes highly political, and the politics of nutrition are just as complex as the science. The current prediction is that we will be hearing much more about the science, medicine, and politics of food. Hippocrates would be pleased. Therefore, it’s extremely important to 19 stimulate and finance more research into this intricate field in order to halt such situations, of which the above mentioned ones are just few examples. Much more could be discussed on the role of food either preventing, treating or even causing disease. 1.4. GASTRONOMY “Gastronomy, has been the joy of all peoples through the ages. It produces beauty and wit and goes hand in hand with goodness of heart and a consideration of others." Charles Pierre Monselet, 1825-88 1.4.1Science The history of food in its most basic sense needs no justification. The idea that a society’s soul is revealed by its cooking has, in fact, been used since earlier times. According to Greek classical and also Chinese tradition, barbarians ate raw and crudely cooking, and this was the essential aspect of their barbarism. The Huns, and eight hundred years later the Mongols, were reputed to cook slabs of meat by placing them between the thigh of the horse rider and his mount28. As these and in many other cases, the identification of a populace by its cuisine is the preoccupation of outside observers and their stereotypic ideas more than an activity of self-reflection. The Greeks played an important role in such science, binding food and eating habits with Medicine and Nutrition in principles still validated nowadays. Theorion, in the 5th. century BC who invented bread ovens and bakeries, plus Mitahecus and Sarambus, the later a wine maker, were considered by Plato the three men who were “best at caring for men’s bodies”. The belief that whole wheat bread is more laxative and healthful promoter than the wheat itself comes from these Greek times, although they themselves preferred the white bread. Furthermore, Dionysius advised that wine drinking was to be practiced in such mode: one to health; one to love and pleasure; and the 3rd to sleep28. It was very common to Greeks to add wine to water at a concentration of 3% to 5%. The other Greek contribution to human diet was olive oil, this sponsored by the Goddess Athena who planted the first olive tree. Refinement in Greek cuisine appears to have been 20 stimulated by both eastern (Lydia and Persian) and western influences (Sicily and South Italy). Eastern influence was marked by the best bread and cake makers, complex dishes and perfumes. The western influence was played by the highly sophisticated professional cooks and cookery book writers imported from Italy. The basic difference between Greeks and Romans seems to be that the first shared their meals usually amongst men while the latter shared them with their wives. According to Popei “the one I do not dine with is a barbarian for me”28. European cuisine was born with the ingenuity of the Sicilian cooks. Their rich cuisine of many ingredients, elaborate sauces and seductive honey-cakes was enjoyed and admired. The Romans were eager to learn from others, especially from the Easterns and maybe due to this, ended up using much spices and exotic sauces in their cuisine. Garum or liquamen was a sauce made of salting the fish and having it fermented with enzymatic and not bacterial action. This sauce was very much similar to the South Asian fish sauces used today. Upon this, it’s almost impossible to dismiss the claim that the Romans had a preference for the taste of rotting food. Garum was produced in factories all over the Roman Empire and it varied in quality, taste, color, and of course, in price. However, it may come as a surprise that all the foods that are considered today as characteristic of the area, such as tomatoes, green peppers, aubergines, oranges and macaroni were not available yet at that time. The Romans essentially ate grains, meat, fish, venison, boar, hare and dormice (all parts of these animals were fully consumed, nothing was wasted). They also ate different kinds of birds and aquatic animals such as oysters, crayfish and prawns. These were available especially in coastal areas. Everything was eaten with different sauces made of a huge variety herbs (parsley, celery leaf, catmint), spices (pepper, cumin, savory, marjoram), liquefiers (garum, fruit juice, wine, vinegar, mustard) and thickeners (egg whites or egg yolks, wheat starch). In addition to the varied and fine cuisine, Romans had the peculiar habit of selling food on the streets and even around the baths, besides in the taverns. Mostly, they liked the plebeian convivium. The Romans succeed in building an empire that 21 survived and resisted internal and external crises for over thousands of years. Meanwhile in the far east Asia, China also played an extremely important role in the world of culinary and its association with health status issues 29 . “Have you eaten? “….this is the most common daily greetings in China and attests to the central position occupied in Chinese lives by food. The most fundamental principle underlying Chinese cuisine is its most distinctive characteristic of fan-cai principle. This divides all foods in two categories: fan denotes rice but it encompasses all grains and such other carbohydrates as bread and noodles; cai denotes the dishes made to flavor the fan, and it is of secondary importance. The Chinese also praised the yin and yang principle of balance into their cuisine. These were not regarded as diametrical opposites but as complementary poles on either end of a spectrum on which any item of food would be. Foods were divided into cooling and heating types according to their effect on the body, this is to say not the temperature they were served, but rather their properties. Chicken soup, for example, was ranked as a heating food while crabs were cooling food. These ideas were further reinforced with the latter introduction of the humoral system. According to this theory, the human body was affected by heat and cold, and to a lesser extent by wetness and dryness, and balance was essential to wellbeing. The humoral system might have reached China from the West as a consequence of Buddhism spread. The Chinese divided the cosmos into five successive phases generated by yin and yang namely, wood, fire, earth, metal and water. Each one had a counterpart in every other group. The most connected to food was the five flavors, that is, acidic or sour, as in vinegar; bitter as in bitter melon and apricot kernels; sweet as in honey and later sugar; pungent as in ginger and garlic and finally; salty as in salt and later soy sauce. Also the Chinese paid much attention to health and hygiene and it explains why freshness and cleanliness has always played a central role in Chinese cuisine. The influence of Chinese cuisine on health issues dates way back from Confucius who very much praised what he ate. His principles were: “do not eat rice which has been damaged by heat or damp and turned sour, nor fish or flesh which has gone bed. Do not eat what 22 is discolored or what is in bad flavor, nor anything which is ill-cooked or not in season”29. The Chinese might also have been the ones who started the idea of dining out. Restaurants, or better say, establishments with the same principle of these were a reality in that country ever since the Song Dynasty in Hangzhou (960–1279 AD). In the late Ming dynasty (1368-1644), Chinese cuisine and thus taste was marked by a burgeoning consumer culture that bestowed enormous prestige upon possession and enjoyment of material things, encouraging a new market in luxuries. This definitely prompted a full interest in gastronomy. Three late Ming authors gave some sense of the epicurean life of this period, both in terms of food itself and in terms of pleasure. Gao Lian, one of these authors, advocated that for elegant living one must share lengthy discourses on food and drinking. He also devoted his energies to questions of health and longevity. In harmony with a general trend towards articulating standards of good taste, Gao’s book “Eight discourses on the art of living from the studio where elegance is valued” was a work of connoisseurship suggesting ways in which one might perfect both one’s material surroundings and one’s metaphysical existence. Out of his eight sections, one was fully devoted to ways of prolonging life and avoiding illness, one to medicine and one to food and drink. So, once again, taste, medicine, nutrition and gastronomy had its destiny connected in the history of these arts. This was later stressed by Yuan Mei29 (figure 4) a famous writer and intellectual who was compared to the French intellectual Brillat-Savarin, for his strong opinions about cooking and because of his insistence on the importance of gourmet knowledge. Figure 4 – Yuan Mei available at http://www.poetry-chaikhana.com/M/MeiYuan/index.htm 23 He stressed that cooks should only and solely use the best-quality ingredients, rejecting anything not absolutely fresh. According to him, cooks should thrive to achieve balance in seasoning and respect the natural flavor of an ingredient; they should also pay attention to hygiene, use separate pans for different flavors and pour water onto tea-leaves only when it reaches boiling point. In summary, Chinese imperial gastronomy consisted of two main branches, procuring and savoring the best and rarest foods and writing about them. This was intertwined to the uncanny resemblance to the fan-cai principle that ordered gastronomy itself to concern for flavor, health and good taste. In the middle East, Islamic cuisine was marked by haram (evil – forbidden) and haial (good - permitted) principles. Muslims similar to Jewish were not allowed to eat certain foods such as pork, blood and improperly slaughter animals. For Jewish much of these prohibitions were presumably made on medical basis, considering that many of these animals lived under dirty conditions. However, there were also other explanations such as the pigs competed with humans for water and grain (scarce commodities in a barren land) in contrast to cattle and sheep which consume relatively little water and graze on forage inedible to man. Since tapeworm and other parasitic infections were also transmitted by sheep and cows, thus singling out pigs would not be wholly logical30. On the other hand, Muslims were enjoined by Allah in to “eat of the good things wherewith We have provided you”. Since the second half of the 8th century there were culinary books in the Arab world. They were written by important people as the brother of Calif Haroum al-Rashid, famous for having invented the eponymous ibrahymyia, a sour meat stew made with verjuice or vinegar31. For Medieval Muslims the most important genres of Arabic culinary literature were the poems of the table, elaborate poetic paeans to food and dining that were recited at dinner parties. Dining was an elaborate lavish matter, something unheard since the 24 Roman times, which direly contrasted to Muhammad’s principles of eating only the necessary. The caliphs would boast of the fact that no less than 300 different dishes might be presented in a single sitting and by doing so they expressed their wealth and power. However, in the same period, dissidents of such principle of life or the so called cult of the stomach, doctors depicted their concepts in dietary treatises which were much similar to the Greek theories. One of such books, the book of Foods (Kitãb al-aghdbiya) written by doctor Ishaq B. Sulayman al-Isra’ili was even translated into Latin and was worth of consultation by many European physicians. The principle was to object to the conspicuous consumption of so much food based on moral grounds since excessive devotion to the stomach prevented true enlightenment. This philosophy was spread to Europe by Ziryab31, a freed slave and musician from Baghdad who found a position in Spain. Although hired as a musician, he became one of the greatest arbiters of taste the world has ever seen. He set the standards for matters of etiquette, fashion and dining. He taught chefs new dishes from the east and introduced some delicacies such as asparagus. Some of these specialties are still in use in current Spain, such as the ziriabi, a dish of roasted and salted broad beans. He also introduced the practice of dining in courses in which soup should be followed by fish, and then fowl or meat, then desserts, ending with a small bowl of pistachios or almonds. In other words, a meal from soup to nuts, a style of dining that has persisted till nowadays. Muslim food was much characterized by intense and diverse flavors always with a touch of rose water to be sprinkled in the very last minute. Interestingly, rice was not all that much prized until mid 16th century when was then elaborated in different pilafs. On the other hand, bread was tremendously prized and the more there was served, the better judged was the host. To complement such specialties, Muslim cuisine was very rich in candies. There were all different kinds which were exported to countries invaded by them, including India. Furthermore, it was a Muslim custom to wipe the sides of the pans with a clean cloth, for no reason other than it would enhance its presentation, characterizing not only the art of cooking but also the art of serving. 25 Meanwhile, in Europe, with the fall of the Roman empire, Christianity played an important role in food habits. This was represented by a swing away from luxury life where gluttony prevailed to a more monastic selfmortification model32. The principle that the human body depended on four related humors seems to have been influenced by eastern philosophies. These were: choler or yellow bile; phlegmon; black bile and; blood. Medieval food matched the individual to foods with the optimum characteristics to achieve a temperate state – warm and moist. Cooking changed a food’s nature: heat dried food; boiling would moisten it. Digestion was a form of cooking to be conducted in a measured way to translate the food into blood or other humor. Over-indulgence at the meal might produce imbalance of humors. So, once again food regains its importance in health and disease. Late medieval medical theory considered that there were eight flavors: sweet, greasy, bitter, salty, sharp, harsh, salty like the sea and vinegary. The eight tastes were linked to humoral analysis and may underlie some of the working of medieval cookery books. Physicians in great households were expected to make this connection. An example of this is present in the history of Duke of Burgundy who when at the table had his physician surveying the foods served to him and advising which would be most profitable to him33. The preserving of meat was developed and fruits were widely consumed as they were indicated as a therapy to invalids. Medieval cookery also revolved around the use of spices under the influence of Muslims. More than 300 spices were described by Florentine Francesco Pegalotti and these were used not only in cookery but also in medicine and beauty products33. Spices played such an important role and were considered the “oil” of the middle ages32. Some authors even advocated that the world of crusades was no quest for Christianity but rather a need to guarantee the supply of these ingredients to an Europe deprived of them due to two great barriers: one political and other geographical. The Ottoman empire would not allow anyone to travel through their domains to look for spices. So, there was no possibility of making the journey that the Polos had made earlier. The other barrier was geographical as no one knew how far south the African continent stretched. The Arabs were at that time 26 the best geographers but they had little desire to escape from the Ptolemaic conception of the world as it was known to the ancient Greeks and they were not prepared to speculate about possible routes to unknown continents. Furthermore, they had a horror of the western ocean beyond Europe and Africa which they referred as the “Green Sea of Darkness”32. Henry the Navigator, the Portuguese infant (1394-1460) was a member of the crusading expedition sent to Ceuta, in North Africa in 1415, with the goal to interrogate the Arabs of the extent of the great trans-Saharan salt trade. Salt was also a very important condiment known by the Arabs who traded it across the Sahara, usually returning from those far sides with leather, goat skins and ivory. The information provided by the prisoners of Ceuta enabled Henry to build up a mental map of the great continent. Surrounded by Jewish and Arab cartographers, he created the beginning of the ocean discovery era of the far sided continents. Henry not was only interested on the spice trading but also on inflicting a decisive defeat on the Muslims, from whom Portugal had only recently freed itself. After Henry, not only Europe was for sure different but also, a world globalization was rocketed. New food ingredients were brought into Europe from the colonies but also new food techniques had to be developed to attend the demands of long months in the seas. The first nutrition deficiencies were reported and ascribed to fresh food deficient intake, such as vitamin C deficiency leading to scurvy. This inflicted so many deaths on sailors. European cuisine was much influenced by the Arabs and it’s possible that the creation of sherbets and ice creams, in Italy, were under the influence of them. Sugar, originally from India, was probably one of the most important new ingredients that changed European habits. Sugar was also recommended by doctors to their patients on account of it health-giving qualities. According to Platina “nothing given us to eat is so flavorless that sugar does not season it”34. It’s interesting to note that the English used less spices than the French but on the other hand ate more sugar. As for the French, spices such as grain of paradise were used in two out of three recipes. One plausible explanation could be the idea brought about with the 27 thought of heaven. Corn, potatoes, chocolate, turkeys were all new ingredients brought to Europe together with a variety of new fruits. Some of these food were changed by European habits. Chocolate was a cold delicacy, not liquid, but frothed to a thick consistency like that o honey, so that it had to be eaten with a spoon, h was taken by the Aztecs as an aphrodisiac beverage. This was brought to Europe by Cortez, a Spanish, who introduced it to the court of Spain. Chocolate continued to be later regarded as aphrodisiac by English and French people, also. Casonova, the famous French playboy was reputed for given his lovers chocolate and guaranteeing his status of a true delicate and honorable lover. Other drinks as coffee and tea were also important at European tables where water, on the other hand, was seldom present, maybe due to the conditions under which it was kept. Coffee and tea, as well as an afternoon snack meal when chocolate was drunk were habits incorporated into the European world. The reputation of coffee as drink that enabled students to burn the midnight oil helped promote the sale of the new exotic beverage. But soon this was questioned by physicians who warned their patients that coffee drinking was the road to ruin32. When towards the end of the seventeenth century a coffee house opened in Marseilles, the town physician held a public meeting to explain to the townspeople just how pernicious a drink coffee was. According to him, the brew was a hot dry substance, which deprived the body of its natural juices, plaguing the drinker with eternal wakefulness, exhaustion and, worse, impotence. The new world agriculture and habits impacted on social ideas and issues. Slavery was a consequence of this new era. Twenty million black men, women and children were carried overseas to plantations in the West Indies, Brazil or America32 and there, they lived under the worst ruthless conditions ever. This raised humanist attitudes in the old continent and the first food boycott ever in history was held by abolitionists who started sweetening their coffee with cream instead of sugar, and asking for French brandy in place of rum. 28 The development of the printing era certainly influenced the world of taste, medicine and gastronomy (not yet used as such). Many books were out on the subject. The first modern cookery book by Maestro Martino de Como (1450) was an asset of gastronomy and medieval commentaries on the philosophy of taste34. Martino’s book was a practical manual for courtly cooks and was later adopted by the humanist writer Bartolomeeo Sacchi (pseudonym Platina) as a reference in his treatise on the science and the art of eating. The Bonessa Voluptate was the first book to be published in three different idioms34. The highlights of this book were moderation and frugality, galenic medical principles that in fact had not really fully disappeared throughout all of those years when gluttony and extravaganza were mostly defended by powerful ruling people. Dietetic concerns ruled out certain foods as dangerous to consume. Platina noted that the properties of mushrooms, for example, were cold and damp and for this reason have the force to poison. In general, meat and fish were considered to be more nourishing and healthier than fruit and vegetables. He also oriented that vegetables should not be eaten after consuming fruit because digestion is hampered by eating so many cool and damp items. According to the galenic dietetic principles every person’s body has its own complex set of humors and properties which must be balanced by various different combinations. One can assume that this was potential the first attempt to individualize nutrition treatments. The table also became a place to show and share social manners. Erasmus in his “De civilitate moreum puerillium”34 advised that “it’s neither polite nor safe to drink or speak with ones mouth full”. Continuous eating should be interrupted now and again with stories.” He also offered his readers practical advice such as “It is boorish to plunge your hands into sauced dishes. You should taste what you want with a knife or a fork; nor should you select from entire dish as epicures do but should take whatever portion is in front of you”. The fork was at that time a rather rare utensil. The first record of a fork comes from Italy, sometime around the XIVth century, but it only became of use around the sixteenth or seventeenth century. Catherine de Medici35 was responsible for its introduction into the French court. 29 Despite the efforts of humanist food writers to emphasize the importance of good taste and good society at the tables, it’s is clear that the princes of the time valued magnificence and ostentatious display at their meals, so Platina’s book was a lonely cry in the wider intellectual culture of the Renaissance humanism and cooking, although important and related to health, did not achieve at that time such a high status as painting and sculpturing. Renaissance involved, at least in its earlier stages, a closing rather than an opening of the mind. The veneration of antiquity became more slavish, authority staked fresh claims against experience. So, the art and science of eating was not as valued as those pieces of art that would call attention to the eyes or to the other senses and to hedonism. It took about two centuries for this to be changed! But things did start moving on when the new science of the seventeenth century, a consequence of the overseas new lands, encouraged an interest in novel foods and drinks. This was based exactly on the previously above mentioned new products brought in from the new world. Many scientists became curious and thus interested in studying the commodities of tobacco, chocolate, tea and coffee. Their familiarity with the Galenic medical model offered them a language they could explain the health benefits of the new exotic products. Coffee, for example, was remarked with the cure of small pox, as well as sugar was prescribed for many disease states. Sweetness was thus transforming the European diet! The birth of a new cuisine was paved by the moto “savory and sweet”. These were the basics for the beginning of the French haute cuisine and the introduction of dessert as the closing of a meal. Till then, most cookery books focused solely on medical and dietetic advice but offered very little practical orientation on how to prepare food. This was to be changed by the book “Le cuisinier Francois” authored by Francois Pierre35 whose pen name was La Varenne. It was the first book which provided recipes to prepare food and not anymore a dietetic manual, despite its still conservative introduction on the importance of good eating habits and, food impact on health and disease. He definitely paved the way to modern gastronomy and introduced important recipes still famous nowadays such as the fricassee and the ragout. Cooking 30 was now a competition and an area of serious debate. It’s perhaps the beginning of a new era: cooking as an art and not solely science anymore! 1.4.2. Art “The discovery of a new dish does much for the happiness of mankind as the discovery of a new star….tell me what to eat and I will tell you what you are. “ (Brillat Savarin – 1755 – 826) Gastronomy is then the link between taste, medicine and nutrition in the scientific arena of the sustaining principles of life maintenance: eating the basic element of human life! Eating, a hugely complex activity, involves innate biochemical processes and cultural phenomena. Thus, gastronomy plays a lot more when it is also linked with the cultural and artistic side of the three other sciences. Thus no better words to describe it: “art of arts”. The word gastronomy per se only appeared around the year of 1800 in the title of a poem by Joseph de Berchoux (1775- 1838). The noun gastronome dates from 1803 and in the Manuel des amphytryons (1808), gastronomy was a means of legitimizing the new social hierarchy that had emerged from the French Revolution36. Antonin Caréme, the first celebrity chef37, chef of the kings and king of chefs, was the landmark of such new phase of this art. Author of many books of which “Le Pâtissier Royal Parisien” was the first, he advised that food should be served on hot plates and insisted in strict hygiene. He also began to form theories about the marriage of wine and food. He also suggested the liberal use of champagne wit food within recipes. Caréme was a master in sculpturing his food assets, mainly desserts and he himself would spend hours in libraries reading and later drawing his future masterpieces (figure 5) 31 Figure 5 - Carême's drawing of the Hermitage Russe which Jacobin constructs for the Prince Regent's dinner in honor of the Russian Ambassador Available at http://www.mirandaneville.com/antonin_careme.php#cherries . His cooking was tempting and once the Prince Regent teased him by saying that “his cooking would be the death of him”. Caréme replied “Your highness, my concern is to tempt your appetite; yours is to curb it.” Caréme praised very much quality and quantity and was firm saying that “the man who calls himself a gourmand but eats like a glutton is not a gourmand. He is a glutton”. His genius was to deploy methods that brought out the natural flavors of food, for example, vegetables should be cooked a little firm. It was his goal to create a gourmand’s paradise while at the same time producing a feast which could, visually live up to the most opulent settings. His influence was all over Europe as he served in England, Russia and Austria. He was able to impact on Russian sauces, by introducing cream instead of only vinegar to make them and supposedly for successfully ridding Russian cooks of their over-reliance on pickling. To western Europe, he brought back the Russian style use of flowers where porcelain and fruit had dominated table decoration. He also imported to France the borsch and koulibiac (a pie with either fish or chicken, boiled eggs and rice). He also endorsed of service à la russe which is the predominant way of serving till nowadays. By the Russian style each course is served to each guest individually. French service was generally used up until then. Under this method, the usually large menu (as many as 32 courses) was brought to the table in two or three parts, and all of the dishes of each part would be placed on the table at once. Guests would help themselves to each dish, most often in a confused and combative manner, those with the longest arms getting their 32 favorites first. Frequently by the time you got too much of the food, it was no longer hot. Then all of the dishes from that part of the service would be cleared from the table and next part or 'service' would be placed on the table in the same manner. Caréme somehow mingled the two systems. The chef’s hat was also introduced by Caréme, and this seems to have happened throughout his Austrian times. By then, Caréme was working for the Ambassador of England, lord Stewart. Every morning, both would meet to discuss the day’s menu in the kitchen, Caréme’s domain. It was when Stewart first noticed his chef different appearance. Antonin had taken to wearing a raised hat, a sort of toque, in contrast to white nightcaps usually worn in kitchens those days. When Stewart asked why, Caréme promptly replied he felt a chef should not dress as for a sickbed. This habit was followed by other chefs in Vienna, then in Paris and then everywhere. The French sauces were revolutionized by Caréme who had on them the basis of its cuisine: velouté, béchamel, espagnol and allemande were all his creations. Furthermore, Caréme had his finger on the role which marketing and later the media would have on the world of gastronomy. People were eager to be with Caréme, to share his company and eat his food and this was mostly used by the French aristocracy to call attention to their society. The Rothschilds were Caréme’s supporters in this new venture, when inviting Lady Morgan to dine and later to write about the chef’s qualities. According to lady Morgan, the once abandon urchin of Rue du Bac had a Paris townhouse, his own coach and his own box at the Paris Opera37. The era where the chef, not the writer or the critic, becomes a celebrity is a culture where food, too is in revolution. This was mostly proven by Brillat Savarin, the French intellectual who wrote the Physiology of Taste38. Savarin discoursed not only on the qualities of food but also on the perceptions and sensations it would bring altogether. He set principles on taste, senses, appetite, food in germs, thirst, drinks, pleasures at the table, impact on sleep and many other topics, including philosophical history of kitchens and even death. Once again, the link between taste, medicine, nutrition and gastronomy was stressed! 33 According to Brillat Savarin, the sensation of taste is a chemical operation produced by humidity. That is to say, the savorous particles must be dissolved in some fluid, so as to be subsequently absorbed by the nervous tubes, feelers, or tendrils, which cover the interior gustatory apparatus38. He was also persuaded that without the interposition of the organs of smell, there would be no complete degustation, and that the taste and the sense of smell form but one sense, of which the mouth is the laboratory and the nose the chimney; or to speak more exactly, that one tastes tactile substances, and the other exhalations. Most of his thoughts have been backed by recent discoveries in the science of taste. Savarin defended that gastronomical knowledge is necessary to all men, for it tends to augment the sum of happiness and gastronomy itself is a scientific definition of all that relates to a man as a feeding animal. For him, the most indispensable quality of a good cook is promptness. 1.5. HEALTH AND DISEASE “Every human being is the author of his own health or disease.” Buddha, 565 B.C. Science validates what our grandmothers and ancestors knew. Rich homemade chicken broths have been used to cure colds. Figure 6 – Feeding the sick. Available at http://wwwihm.nlm.nih.gov/ihm/images/A/21/484.jpg 34 Stock contains minerals in a form the body can absorb easily—not just calcium but also magnesium, phosphorus, silicon, sulphur and trace minerals. It contains the broken down material from cartilage and tendons— stuff like chondroitin sulphates and glucosamine, now sold as expensive supplements for arthritis and joint pain, which not necessarily function as sold out for. Of course that the intake of such substances, in a short period of time, does not impact on disease, but sure enough plays a placebo role in the treatment of the sick and guarantees a fairly well good intake of nutrients to the anorexic sick patient. Fish stock, according to traditional lore, helps boys grow up into strong men, makes childbirth easy and cures fatigue. “Fish broth will cure anything,” is another South American proverb. Broth and soup made with fish heads and carcasses provide iodine and thyroid strengthening substances. When broth is cooled, it congeals due to the presence of gelatin. The use of gelatin as a therapeutic agent goes back to the ancient Chinese. Gelatin was probably the first functional food, dating from the invention of the “digestor” by the Frenchman Papin, in 1682. Papin’s digestor consisted of an apparatus for cooking bones or meat with steam to extract the gelatin. Gelatin held a position in the forefront of food research some 200 years ago, just as vitamins and other nutrients (for example, omega-3 fatty acids) occupy the center of the stage in nutritional investigations today. At that time, gelatin was universally acclaimed as a most nutritious foodstuff particularly by the French, who were seeking ways to feed their armies and vast numbers of homeless in Paris and other cities. Although gelatin is not a complete protein, containing only the amino acids arginine and glycine in large amounts, it may act as a protein sparer. During the siege of Paris, when vegetables and meat were scarce, a doctor named Guerard put his patients on gelatin bouillon with some added fat and they survived in good health. The French were the leaders in gelatin research, which continued up to the 1950s. Gelatin was found to be useful in the treatment of a long list of diseases including peptic ulcers, tuberculosis, diabetes, muscle diseases, infectious diseases, jaundice and cancer. Babies had fewer digestive problems when gelatin was added to their milk. However, nowadays, no one 35 would keep patients solely on gelatin for any kind of treatment and as it has happened with many other such food supplements used to treat everything and anything, it is now an out fashion topic in the literature. Nonetheless, the nourishing properties of soups have been advocated by many people. Even the epicures recognized that broth-based soup did more than please the taste buds. Jean Anthelme Brillat-Savarin said, “Soup is a healthy, light, nourishing food, good for all of humanity; it pleases the stomach, stimulates the appetite and prepares the digestion.” Escoffier said : “Indeed, stock is everything in cooking. Without it, nothing can be done.” A cure-all in traditional households and the magic ingredient in classic gourmet cuisine, stock or broth made from bones of chicken, fish and beef builds strong bones, assuages sore throats, nurtures the sick, puts vigor in the step and sparkles in love life—so say grandmothers, midwives and healers. For chefs, stock is the magic elixir for making soul-warming soups and matchless sauces. Meat and fish stocks play a role in ill traditional cuisines worldwide—French, Italian, Chinese, Japanese, African, South American, Middle Eastern and Russian. 1.5.1. Eating habits Eating habits have been influenced by the history of evolution of man. Man probably felt compelled to get up on his hind legs, so as to have to use the two hands to carry out some eating process. Later on, by abandoning his original food gathering for a hunting diet man left instinct behind him and he had now to work out everything for himself. So, he began to acquire shaper intelligence and a larger brain39 to cope with the new problems forced on him by a change of diet32. Larger brains are energetically expensive, and humans spend a larger proportion of their energy budget on brain metabolism. The high costs of large humans brains (we have the largest compared to total body surface) are supported by our energy and nutrient rich diets. Consistent with an adaptation to a high quality diet, humans have relatively small gastrointestinal tracts39. In addition humans are relatively under muscled and over fat compared to other animals, features that help us offset the high energy demands of our brains. 36 The change to a meat diet undoubtedly made man more productive and probably altered his whole physique for the better. However, a meat diet presented with drawbacks and salt dependency was one of them. Salt is present in meat in great quantity. Also cannibalism is thought to have been a consequence of protein shortage. It’s true that cannibals also devoured their victims with the hope they would inherit the mama 32 or magical power that they attributed to some of their victims. The discovery of fire rocketed food variety and also the idea of commensality. Cooking also increased the nutritional quality of tubers by making more of the carbohydrate energy available for biological processes. According to Carleton Cook32, fire may have been a decisive factor in leading man from primarily animal existence into one that was more fully human. In summary although dietary change may not have been the prime force responsible for the evolution of large human brain size, improvements in dietary quality appear to have been a necessary condition for promoting encephalization in the human lineage. Therefore, whatever man inherited from his ancestrals, he has carried out till nowadays into his basic eating habits. Socio-economical aspects have also played a role on eating habits. This has been much seen throughout the centuries but currently is still a huge problem worldwide, when poor countries in Africa, Asia and also Latin America present with higher rates of malnutrition due to lack of food. The map of hunger (figure 6) is an uncontested proof of how underdeveloped nations are plunged by lack of food resources. 37 Figure 7 – The map of hunger available at http: //www.cdc.gov/ Subjective variables such as genetic and learning aspects are also related to eating habits. Innate predisposition towards tastes, such as sweet tastes, measured by observation of facial expressions present in neonates, as well as aversion to sour or bitter tastes seem to be related to adaptive human evolution40. Sweetness indicates the presence of sugars and valuable calories, whereas bitterness or sourness may signal the presence of harmful toxins or bacteria. Whilst not present at birth, preference for salty tastes appears at around four months of age. 1.5.2. Commensality Commensality is eating with other people, and commensal eating patterns reflect the social relationships of individuals. When man started gathering around fire, this new concept was born. The invention of fire which was important in every sense, specially because the climate was becoming much colder, brought man together around it to warm himself up and to cook food. Eating hot food raises a well-being which might be rooted in a strong recollection feeling, perhaps of mother’s milk. 38 The first reports of banquets date back from Sumeria, in ancient Near East. Sumerians shared public and private banquets for both political and social reasons. To eat and drink together was a way of strengthening relationships and doing good business. This has raised the idea of ceremony, which according to the dictionary is a formal act or series of acts prescribed by ritual, protocol or convention. Ceremony refers to activities that take place on special occasions and that are consciously designed to produce beneficial effects41. Food-related ceremonies have marked humanity in a way that they have been the center of joyful moments as well as of sad ones. Birth is celebrated with food and death also. In many ancient and yet current cultures the dead are buried with food offers next to them. Food has always been in the center of man’s festivities, no matter what. Certainly due to this, man’s life has been marked by food not only for its basic life sustaining role but also for man’s well being. These ceremonies can be passed down as family traditions or religious practices and can range from something as simple as saying a blessing before eating to elaborate processes surrounding the hunting, gathering, preparation, and eating of food. There is a growing body of evidence that the consumption of food as part of a functional ceremony has distinct health benefits. Even as early as the year 1180, Moses Maimonides, a noted physician and rabbi, remarked that one “should not gorge himself, but leave the table before his appetite is fully appeased, using one fourth less food that what would completely gratify him”41. Medieval theologian Thomas Aquinas said of gluttony: “gluttony denotes, not only desire of eating and drinking, but an inordinate desire….leaving the order of reason, wherein the good of moral virtue consists”41. Several more recent studies have depicted how important the role of commensality is on a society’s development and on individual life style patterns and health issues. In a recent study, meal partners in commensal units and frequency of eating with others in commensal circles among 663 adults was assessed. Meal partner data revealed that most respondents ate alone at breakfast, alone or with co-workers at lunch and with family 39 members at dinner. Commensal frequency data revealed some eating at the homes of other family members, little eating at friends' homes, and almost no eating at neighbors' homes. Few demographic variations existed in commensal eating, except that unmarried individuals more often ate breakfast and dinner alone and more often ate with friends. These finding suggest that contemporary work-oriented society may lead people to eat alone during the day but share evening meals with family, and that people maintain commensal relationships primarily with family members rather than friends or neighbors. Peoples' social worlds appear to be focused on the nuclear family, and family members are also the people they usually eat with42. Family bounds play an important role on the upbringing and eating habits of tomorrow’s adults. A recent study43 showed that girls who ate three to four family meals per week were at approximately one third the risk for extreme weight control practices, and girls who ate five family meals per week were at approximately one fourth the risk for extreme weight control practices. It also revealed that boys also benefit from family meals, but the association was not as strong as it is for girls. In another study44, in which approximately one quarter (26.8%) of respondents ate seven or more family meals in the past week, and approximately one quarter (23.1%) ate family meals two times or less, the frequency of family meals was inversely associated with tobacco, alcohol, and marijuana use; low grade-point average; depressive symptoms; and suicide involvement after controlling for family connectedness. These findings suggested that eating family meals may enhance the health and wellbeing of adolescents. The National Center on Addiction and Substance Abuse at Columbia University’s (CASA) Family Day survey showed that of 1,987 teens ages 12 to 17 years, the number of teens who have regular family dinners drops by 50% as their substance abuse risk increases sevenfold. The survey demonstrates the importance of regular family dinners, finding that, compared with teens who have family dinners twice a week or less, teens who have dinner with their families five or more nights in a week are 32% likelier never to have tried cigarettes (86% vs 65%, respectively), 45% likelier 40 never to have tried alcohol (68% vs 47%, respectively), and 24% likelier never to have smoked pot (88% vs 71%, respectively)45. From historical, cultural, and scientific perspectives, the gathering, preparation, and consumption of food seems inextricably linked to religious and ceremonial beliefs and practices. The growing body of evidence supporting the health benefits of family meals is compelling and should point us toward integrating ceremonial approaches to current and future educational nutritional programs. 1.5.3. Learning attitudes Poor nutrition is a leading lifestyle factor related to the development of several noncommunicable diseases. One strategy for eliminating health disparities and promoting long-term health is to get children to eat and like healthful foods (eg, fruits and vegetables) from an early age. This (learning attitudes) has been proven to be the factor mostly related to adequate eating habits. Children are influenced by their mother’s eating and drinking patterns while still in their mother’s wombs. More than one glass of beer, wine or spirits per week during the pregnancy can be detected at birth. Alcohol in early pregnancy--just when many mothers are unaware they are pregnant can produce significant physical malformation, especially in the face. Prenatal exposure to alcohol has significant effects on the intelligence and behavior of the child. Many of these children are very restless46. Thus, the impact on food preferences has also been attributed to mothers’ eating patterns and habits. Prenatal developmental events appear to influence infant and child preferences for salty tastes47. Some studies suggest that severe maternal emesis can have an enduring influence on response of offspring to salty taste. Similarly, several behavioral measures related to salty taste preference were inversely related to birth weight over the first four years of life. In contrast to flavor compounds detected by the sense of taste, preferences for flavor compounds detected by the sense of smell are generally more highly 41 influenced with learning early in life, even in the uterus, being particularly salient. The sensory environment, in which the fetus lives, the amniotic sac, changes as a function of the food choices of the mother as dietary flavors are transmitted and flavor amniotic fluid. Experiences with such flavors lead to heightened preferences for these flavors shortly at birth and at weaning. Specifically, prenatal experiences with food flavors, which are transmitted from the mother’s diet to amniotic fluid, lead to greater acceptance and enjoyment of these foods during weaning. In an experimental study, infants whose mothers were randomly assigned to drink carrot juice during the last trimester of pregnancy enjoyed carrot-flavored cereals more than infants whose mothers did not drink carrot juice or eat carrots48. The best predictor of how much fruits and vegetables children eat is whether they like the taste of these foods. The most salient feature of the foods and beverages we consume is flavor. We define flavor as the perceptual combination of three anatomically distinct chemical senses: taste, smell, and chemosensory irritation, as previously depicted in this review. Health organizations worldwide recommend five to 13 servings of fruits and vegetables per day, depending on one's caloric requirement Despite such recommendations, adults are not eating enough fruits and vegetables and neither are children. The 2004 Feeding Infant and Toddlers Study49, designed to update knowledge on the feeding patterns of American children, alarmingly revealed that toddlers ate more fruits than vegetables and one in four did not even consume one vegetable on a given day. Instead, they were more likely to be eating fatty foods and sweet-tasting snacks and beverages and less likely to be eating vegetables. None of the top five vegetables consumed by toddlers was a dark green vegetable, those that are usually most bitter. As a consequence, scientific evidence has placed community nutrition among the front line strategies in health promotion. Traditional food habits have progressively changed in the last few decades. The combination of 42 changes in food patterns and sedentary lifestyles has contributed to a significant increase in the prevalence of overweight and obesity. Efforts in community nutrition should now focus on three key aspects: nutrition education in schools and in the community, food safety and enhanced culinary skills in all age groups. School meals and other catering services provided at work or community sites should be consistent with the educational message. Catering services should ensure adequate nutritional supply, foster healthy eating practices and encourage participation in gastronomic culture and social learning. Food safety includes the procurement of a safe adequate food supply in sufficient amounts to cover the nutritional requirements of all individuals. It has become a priority for Public Health. Social changes along new scientific developments will introduce new demands into community nutrition and request a more important role for individually tailored advice. In order to face these challenges, community nutrition professionals need to be highly qualified and skilled. 1.5.4. Disease Every disease represents a stressful situation, thus an imbalance milieu. Stress is a term applied to the fields of physiology and neuroendocrinology to refer to those forces or factors that cause disequilibrium to an organism and therefore threaten homeostasis50. The stressors might be a consequence of physical injury, mechanical disruptions, chemical changes or emotional factors. The body’s response to these factors will depend on the magnitude of them, on the duration of the events and also on the nutritional status of the patients. Complex sensory systems trigger reflex nervous system responses to the stressors that alert the central nervous system (CNS) of the disturbance. In the CNS, neurons of the paraventricular nucleous of the hypothalamus elaborate corticotropinreleasing hormone (CRH) and activate the hypothalamic-pituitary-adrenal axis (HPA). In addition, other areas of the brain signal the peripheral autonomic nervous system. These two latter systems elicit an integratedresponse, referred collectively as the “stress response”, which primarily 43 controls bodily functions such as arousal, cardiovascular tone, respiration, and intermediate metabolism. Other functions such as feeding and sexual behavior are suppressed, as while cognition and emotion are activated. In addition, gastrointestinal activity and immune/inflammatory responses are altered. Therefore, it’s crucial to understand that the disease process per se impacts on eating patterns, by causing anorexia, thus hampering intake. The disease may also raise basic energetic requirements and interfere with absorption and excretion of nutrients. This explains the high prevalence of malnutrition among hospitalized patients18-20. Nutrition although fundamental to anyone’s survival has had for many years a supporting role in patient care and, it still is nowadays not seen as a sustaining therapy to most patients throughout the world. Even in referral centers in the USA or other first world countries, it’s incredible to notice that its importance from the administration perspective is not as relevant as sophisticated procedures such as small bowel transplantation or new diagnostic tools, not to mention the lack of medical awareness towards basic nutritional issues such as the prevalence of malnutrition18, 51, 52 . Major investments in such sophisticated procedures are a reality, in detriment of nutrition therapy teams which have decreased in American hospitals and in some countries don’t even exist. One potential explanation for this is that malnutrition/undernutrion is still under assessed 18, 20 and, with the booming of obesity, diagnosing such condition is even more difficult for those not aware of the problem. In addition, we lack good powered prospective clinical trials to show that malnutrition is directly associated with poorer outcome, longer length of hospital stay, higher mortality and increased costs. Upon such reality, one is prone to question what have we missed to justify that about 30 years after Butterworth’s paper “The skeleton in the hospital closet” 52 , the prevalence of such condition is still highly prevalent in hospitalized patients worldwide 18, 20, 53? Putting more fire into the woods…..old paradigms still mark patient’s nutritional treatments in the hospital setting as well as in the community. Long fasting hours/days before and after surgery are a routine practice 44 worldwide, despite its related reported side effects54, 55 . In current surgical practices it is advised that patients be treated under multimodal practices as the ones proposed by Fearon et al in the enhancing recovery after surgery protocol (Figure 8)54. Figure 8 – Enhancing recovery after surgery protocol 54 Eating or being fed as soon as possible after surgery has also been recommended as ways of decreasing post-operative intestinal dysfunction (paralitic ileus), bacterial translocation and by so concomitantly decrease overall complications, death rates and length of hospitalization. In the most recent study on postoperative feeding, Lassen et al. 56 have shown that patients undergoing major abdominal surgery who were early fed with regular diets resumed bowel function significantly earlier and had decreased total number of major complications, length of stay, and rate of post discharge complications. Allowing patients to eat normal food at will from the first day after major upper gastrointestinal surgery does not increase morbidity compared with traditional care with nil-by-mouth and enteral feeding. 45 In hospital nutrition, unfortunately, is still based on mass treatments. This is to say, very seldom are patients’ food preferences respected individually. In such sense, this is another factor that contributes to the high rate of malnutrition and great wastage of food in this setting. The provision of good quality food, fluids, and nutritional care should be an integral part of the therapeutic care in a hospital. Meeting patients’ nutritional requirements will help them get well. Optimizing menu design, adapting menus, and improving the mealtime atmosphere are vital steps to fight malnutrition in the hospital. When a menu is planned, disease- or therapy-related feeding problems such as loss of appetite, changes in taste perception, or difficulty chewing and swallowing must be taken into account. On the one hand, the hospital’s catering department must be able to deal with individual patients’ needs and preferences as well as offering a balanced menu that meets the patients’ nutritional requirements. On the other hand, from an economic point of view, food wastage should be minimized, since wastage can be as high as 67%57. The term food chain (figure 9) has been adopted to emphasize that all stages in the provision of food must be adequate, from screening of patients and planning of menus to the distribution and serving of the food. It is desirable for hospitals to appoint a multidisciplinary and multiprofessional nutrition steering group, including the clinical nutrition team, to oversee all aspects of nutritional care, from catering to artificial nutrition. A failure at any point disrupts the system. The system on the ward should be designed to prevent interruption of meals by procedures, rounds etc. Food taste and intake should be monitored and audited regularly, with modification of policies as necessary. Furthermore, quality control initiatives should evaluate whether recommendations for adequate hospital nutrition are met. Various aspects of food provision should be monitored regularly, including portion control, presentation, flavor and texture, temperature, timing of service, and patient satisfaction. 46 Figure 9 – Food chain in the hospital setting 57 Food restrictions are routinely applied to certain groups of patients, such as those with cancer, diabetes and renal diseases based on old principles not supported anymore by current evidences (figure 10). Physicians should be forbidden to forbid their patients from eating whatever pleases them, especially in situations that anorexia prevails. There is very few evidence to support most of the nutrition recommendations directed at these groups of individuals. As an example, renal patients are generally those suffering some of the most restricted diets prescribed to any individual. These diets are very much arguably and many of the restrictions contradict current recommendations for healthy eating. Some of the most notably restrictions are around consumption of fruit and vegetables due to their high potassium content. However, most of the times, according to the patient’s treatment regimen, this type of restriction is not at indicated at all. A recent study58 highlighted issues and beliefs, such as the importance of receiving dietary advice at diagnosis from a renal dietitian, to limit confusion and conflicting advice. It also identified the importance of diet as perceived by patients in relation to their renal disease and the changes in perceived importance 47 associated with disease progression. Dialysis patients ranked dialysis as more important than diet whilst nephrology patients, although perceiving diet to be important, had received little or no nutritional advice. Confusion and frustration was expressed in trying to implement the restrictive dietary advice especially if renal disease was coupled with other comorbidities. Figure 10 – Forbidden to forbid. Available at http://wwwihm.nlm.nih.gov/ihm/images/A/12/867.jpg 1.5.5. Molecular gastronomy Physicians try to understand the origin of certain diseases such as cancer for example, molecular biologists explore the genome, embryologists study the build-up of living organisms, nutritionists try to associate nutrients with health and disease and chemists unravel the details of chemical processes. Cooking is such an important part of our world (even the smallest 48 flat has a room for it) that it is worth specific scientific studies. The scientific discipline devoted to culinary transformations, and to gastronomical phenomena in general has been called Molecular Gastronomy59. This discipline is part of food science, but research is focused on (mainly home or restaurant) culinary transformations and eating phenomena rather than the physical and chemical structure of ingredients. As recipes describe culinary transformations, it is useful to examine recipes, in order to understand the scientific strategy of the discipline. According to This59, the following recipe is from a culinary book published in France at the beginning of the 20th century (Anonymous, 1905): “Take a dozen pears of middle size, remove the skin and put them immediately in cold water. Then melt 125 g of sugar with some water in a pan at low heat: as soon as the sugar is melted, add the pears, add some lemon juice if you want to keep the pears white; if you prefer them red, do not add lemon juice and cook them pan lined with tin.” In this recipe, the words in bold characters give a definition of the dish; it can be observed that this definition here is less than 10% of the recipe. The words in italics add ‘precisions’ (orders, orientations, steps to be followed), a category that includes old wives’ tales, proverbs, and sayings. . . Depending on the recipe and author, the precision content of recipes can vary considerably; for example, in some recipes from the French cook Jules Gouffe´ (1867), the precision percentage is nil. The pear recipe indicates the scientific strategy of molecular gastronomy: it should model the definitions and explore the precisions. Describing ingredients and dishes is only one part of the modeling process, the other part being culinary transformations. What does ‘cooking’ mean, in particular? Cooking is a complex chemical process that according to the way it’s performed enhances tastes, disperses flavors, softens or hardens ingredients and at the end offers one something that might be either extremely delicious or something not even worth a try. To exemplify what has been said, This 60 tells us that “chefs cook green beans in boiling salty water; when the beans are cooked (decided either by smell, texture or flavor), 49 they are strained, then immediately refreshed in icy cold water in order to, chefs say, “fix the chlorophyll”. When asked, chefs admit that “fixing the chlorophyll” means keeping the brilliant green color of vegetables — but they forget that raw green beans are actually less green than when they are cooked! Is icy cold water useful to keep the green color? This59 and his group investigated the matter further in terms of chemical reactions. Chlorophyll pheophytinization (the replacement of the magnesium atom by a proton, at the centre of the chlorophyll molecule) changes the green color of chlorophyll into an olive–brown color. It has been shown that the correlation between chlorophyll pheophytinization and the green color (as measured by colorimetry) of cooked beans is poor. By UV spectroscopy of extracted pigments, it has been found that cooling the green beans in ice has no effect on the color. Another very good example of cooking alchemy is the story of mayonnaise. Discussion of mayonnaise could fill books, because the sauce is very popular and it has generated many culinary precisions with different assumptions and explanations for such phenomena that either explain or justify its success or failure. It also helps to understand the reason why culinary precisions arose. Most modern mayonnaise recipes say to add oil to a mixture of egg yolk and vinegar (definition), but many authors add precisions (orientations). Some state that the temperature of the room where the mayonnaise is made should not be too hot or that the sauce should be made in a vessel lying on ice cubes; others state, on the contrary, that a cold room temperature is responsible for failure; and others state that oil and eggs should be at the same temperature. Other causes of failure are frequently given: for example, many cooks, in particular in France, think that mayonnaise fails when it is made by women having their periods, or that the cook should always turn the spoon or whisk in the vessel in the same direction. This tested all these precisions60 and it was easily seen that women’s periods and the direction of whipping do not lead to failure. The question of temperature was also checked, with eggs from the fridge (4 °C) and oil at 50 room temperature (35 °C), or the reverse, and no effect of temperature was observed. This was expected, because mayonnaise is ‘only’ an emulsion, that is, a dispersion of oil droplets in water; the temperature range of the emulsion stability is quite wide, and so temperature becomes only the main factor for stability under the crystallization temperature of oil, or above protein denaturation points (the first one is at 62 °C, for gamma livetin). However, some precisions were correct. For example, it was sometimes written that oil should be added ‘drop by drop’ at the beginning of the sauce preparation. It is true that mayonnaise fails if too much oil is added first, as water is then dispersed into oil, instead of oil into water. The latter is more stable because of the particular nature of the surfactants from the yolks: proteins and lecithins, which curve the oil/water interface so that oil forms droplets. So what is the future of food once we start to explore it scientifically? The difficult thing about the future is that it is hard to predict. We should avoid making the same mistakes that French chemist Marcellin Berthelot made about a century ago: he predicted that the success of organic chemistry would allow us to abandon traditional food and, by the year 2000, eat nutritive tablets instead61. He was obviously wrong—humans are living organisms, with an extremely sophisticated sensory apparatus that has evolved over millions of years to detect odour, taste, consistency, temperature and more. The pleasure of eating involves all our senses and it is obviously important for our wellbeing, as depicted throughout this review. Obesity and other related diseases are growing, hospital nutrition is still a huge challenge and the pleasure of eating cannot be measured based solely on daily nutritional requirements. Hedonism must be a part of this process as well as the chemistry of cooking. All these justify why scientists, physicians, nutritionist, psychologist, chemists and cooks should all endeavor efforts to understand each one’s role into this intricate process and should develop strategies to help promote good healthy eating habits. For many years and still current practice, most guides against obesity and other related diseases have focused solely on eating habits, exercise and related variables (figure 11). Nothing has been directed to scientific cooking as 51 understanding the alchemy involved in the cooking and preparation process of healthy meals. Fig Available 11 – Be healthy. Available at http://wlewihm.nlm.nih.gov/ihm/images/A/25/622.jpg Figure Such efforts should be started early in life, as children must get more information about food and food preparation, its benefits and consequences, avoiding thus the fatal attraction to junk food, soft drinks and sweets. Consequently, health programmes that promote a balanced diet cannot succeed if people are unable to make intelligent choices about food. However, traditional cooking is not a guarantee either for healthy food or for a rational preparation of food. This is where the scientific programme of molecular gastronomy can be useful. If we are able to use the knowledge gained on food preparation, we might find new ways to make healthy food more attractive, we might persuade more people to cook better food and, last but not least, we might convince society to regard eating as a pleasure rather than a necessity61. Without more knowledge, culinary books cannot be regarded as reliable. Moreover, educational programmes cannot rely only on traditional recipes, because products, methods and ingredients have 52 changed over time. Cooking has to be explored scientifically if we want to improve educational health programmes. 53 2. CONCLUSION “Learn from yesterday, live for today, hope for tomorrow. The important thing is not to stop questioning.” Albert Einstein, 1879 -‐ 1955 54 2. CONCLUSION “We are not certain, we are never certain. If we were we could reach some conclusions, and we could, at last, make others take us seriously.” Albert Camus, 1913 - 1960 Taste, nutrition, medicine, food, chemistry, gastronomy and molecular gastronomy all intermingle. They are part of a science of many sciences enrolled in the act of eating. They represent human history and evolution! Therefore, it’s extremely difficult to separate them from this intricate web, into science or art…….perhaps, they shall be the two! Somehow, similar to health and disease, which are also two complete opposing words, although almost paradoxically similar as they are side by side in the reality of life. So should be taste, medicine, nutrition and molecular gastronomy……. 55 3. FUTURE PERSPECTIVES “When one door closes another door opens; but we so often look so long and so regretfully upon the closed door, that we do not see the ones which open for us.” Alexander Graham Bell, 1847 - 1922 56 3. FUTURE PERSPECTIVES “The most pathetic person in the world is someone who has sight, but has no vision.” Helen Keller, 1880 - 1968 I would very much like to see a future where all these arts and sciences were approached by multiprofessional teams of experts rather than individuals competing for the success of one over the other. 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