annual report 2012 - High Impact Research
Transcription
annual report 2012 - High Impact Research
ANNUAL REPORT 2012 HIGH IMPACT RESEARCH GRANT HIGH IMPACT RESEARCH GRANT ANNUAL REPORT 2012 Secretariat, High Impact Research Grant Level 1, High Impact Research Building University of Malaya, 50603 Kuala Lumpur www.hir.um.edu.my / hirgrant@gmail.com 2 High Impact Research Annual Report 2012 High Impact Research Annual Report 2012 Message from Chairman 7 HIR Committees • Central and Faculty 8 HIR Secretariat • Faculty 11 • Central 12 HIR Advisory Council 13 HIR Background 16 Summary of Projects 16 International Collaborators 24 List of Publications HIR MoHE 2012 34 List of Presentations HIR MoHE 2012 56 List of Successful Applicants (cycle 2012) • HIR 2 years 74 • HIR-MoHE 4 years 75 Research Proposals (cycle 2012) • HIR 2 years 78 • HIR-MoHE (Medicine) 91 • HIR-MoHE (Engineering) 98 • HIR-MoHE (Dentistry) 125 • HIR-MoHE (Computer Science & Information Technology) 141 • HIR-MoHE (Chancellory) 147 UM HIR Publication Highlights 2012 150 UM HIR Special Features 2012 154 HIR Activity Highlights 160 University of Malaya Central High Impact Research (HIR) Core Research Facilities 172 Financial Statement 178 HIR Faculty 179 Contact person of HIR Secretariat 181 Photo Gallery 182 CONTENT 3 4 High Impact Research Annual Report 2012 MESSAGE FROM CHAIRMAN HIR COMMITTEES • • Central Faculty HIR SECRETARIAT • • Faculties Central HIR ADVISORY COUNCIL 6 High Impact Research Annual Report 2012 High Impact Research Annual Report 2012 7 “This has undoubtedly began to make an impact in the ranking scores of UM under the QS World University Ranking, lifting UM from 167 in 2011 to 156 in 2012.” Professor Tan Sri Ghauth Jasmon This year, the HIR programme in UM has undergone a phase of consolidation and started to make significant progress. It continues to garner attention, both locally and overseas, with many new international collaborators from world-class universities and institutions joining in our research efforts. We have appointed Dr. Wong Chi-Huey, a world-renowned organic chemist and President of Academia Sinica, Taiwan, as our UM Distinguished Fellow and he also serves as a member of the UM HIR Advisory Council. President Wong has agreed to support joint research between Academia Sinica and UM, thus enhancing the already excellent research collaboration between UM and Taiwan universities and institutions. This year also sees the initiation of 53 new projects funded under the special HIR allocation provided by the Ministry of Higher Education (MOHE) Malaysia. “As Chairman of the HIR Committee, I am thrilled with the significant progress that has taken place so far. Clearly the coming year will see greater achievements by HIR as many of the projects will begin to bear results and we can expect them to bear a bountiful harvest.” This makes it a total of 128 MoHE funded projects amounting to RM425 million for the period ending December 2012. The balance of RM165 million out of the total MoHE allocation of RM590 million will be used to fund new projects in 2013. October 6 was a red letter day for HIR when renovation to Level 1 of the HIR Building was completed after 5 months. Many new equipment have now been moved in and commis-sioned, and training courses in the use of high-end equipment are being conducted. The pride of this new place was the commissioning of two multi-million ringgit instruments for next generation sequencing, Illumina HiSeq NGS and PacBio SMRT, along with about 20 other high-end instruments. Last year also marked the first anniversary of HIR MoHE. Although still in its infancy, having commenced in August 2011, HIR has already generated more than 400 Tier 1 ISI-indexed publications. Some significant publications have appeared in such top journals as Nature Genetics, Nature Medicine and Lancet. This has undoubtedly began to make an impact in the ranking scores of UM under the QS World University Ranking, lifting UM from 167 in 2011 to 156 in 2012. It is also noted that among the 5 research universities in the country, UM continues to build a bigger lead among the pack in terms of ISI/WoS publications, achieving 1991 ISI publications in 2012 as compared to 1,500 for the second ranked university. The HIR Committee lost the service of Prof Ishak Abd Razak when he went on retirement. In his place, we have appointed Prof Rofina Yasmin Othman from the Institute of Biological Sciences. Prof. Rofina Yasmin focuses her research interest in utilizing modern biotechnolo-gy strategies to tackle fundamental problems in agriculture and runs an active research group in the Centre for Research in Biotechnology for Agriculture in UM. She has just returned to the university following a 3 years’ secondment to the Biotechnology Division, Ministry of Science, Technology and Innovation Malaysia. As Chairman of the HIR Committee, I am thrilled with the significant progress that has taken place so far. Clearly the coming year will see greater achievements by HIR as many of the projects will begin to bear results and we can expect them to bear a bountiful harvest. How-ever, we must not lose sight of our principal goal of ultimately making UM rise into the world’s top 100 university through High Impact Research. Best personal regards GHAUTH JASMON 31st December 2012 MESSAGE FROM DR. GHAUTH JASMON Chairman of HIR Committee 8 High Impact Research Annual Report 2012 HIR COMMITTEE HIR COMMITTEE CENTRAL From left to right Emeritus Professor Dr. Yong Hoi Sen, Professor Tan Sri Ghauth Jasmon (Chairman), Professor Dr. Mohd Ali Hashim, Professor Dr. Rofina Yasmin Othman, Professor Dr. Mohd Amin Jalaludin, Emeritus Professor Dr. Lam Sai Kit, *Not in Picture : Puan Haliza Harun FACULTY OF MEDICINE From left to right Professor Dr. Amru Nasrulhaq Boyce, Professor Dr. Mohd Amin Jalaludin, Professor Dr. Adeeba Kamarulzaman (Chairman), Professor Dr. Goh Khean Lee, Professor Dr. Tunku Kamarul Zaman Tunku Zainol Abidin High Impact Research Annual Report 2012 FACULTY OF ENGINEERING From left to right Professor Dr. Nik Meriam Nik Sulaiman, Associate Professor Dr. Faisal Rafiq Mahamd Adikan, Professor Dr. Masjuki Haji Hassan, Puan Mariam Ali FACULTY OF SCIENCE From left to right Professor Dr. Chong Ving Ching, Professor Dr. Mohd Sofian Azirun (Chairman), Associate Professor Dr. Sithi V. Muniandy, Emeritus Professor Dr. Lam Sai Kit, Professor Dr. Mohd Ali Hashim 9 10 High Impact Research Annual Report 2012 FACULTY OF DENTISTRY From left to right Associate Professor Dr. Noor Hayaty Abu Kasim, Professor Dr. Rosnah Mohd. Zain (Chairman), Professor Dr. Edward Tiekink, Professor Dr. Lui Joo Loon FACULTY OF COMPUTER SCIENCES & INFORMATION TECHNOLOGY From left to right Professor Dr. Siti Salwah Salim (Chairman), Professor Dr. Lam Sai Kit, Emeritus Pr Professor Dr. Masjuki Haji Hassan, Professor Dr. Wan Ahmad Tajuddin Wan Abdullah, Associate Professor Dr. Abdullah Ghani, Professor Dr. Ong Seng Huat Nur Fazlin Mahfodz, Azizah Ahmad, Norshida Abdul Manan, Anis Yusnida Zakaria, Nabilah Ahmad, Nur Syafiqah Abd Malek, Norshahidayu Ali, Siti Zawahir Zubir, Mariam Ali, Lim Moo Eng, Sarina Ramli, Lily@Sharipah Noriah Zainal Abidin, Mariah Mansor From left to right (front) Nur Syahrinar Anuar, Siti Fatimah Zahra Mohd Anuar, Amirul Asraf Mohd Jurami, Mohd Faiz Ibrahim, Arif Fakhri Johari, Norsaidin Mahusin, Azbullah Che Ibrahim, Muhammad Khlaid Hashim, Alsaddam Suhaimi, Muhamad Afiq Zaini Alamar, Hamizah Husain, Ain Valerie Cassera Rapoi From left to right (back) HIR SECRETARIAT (FACULTIES) High Impact Research Annual Report 2012 11 12 High Impact Research Annual Report 2012 SECRETARIAT HIR CENTRAL From left to right (back) Alsaddam Suhaimi, Arif Fakhri Johari, Azbullah Che Ibrahim, Lim Moo Eng From left to right (front) Nabilah Ahmad, Ain Valerie Cassera Rapoi, Norshahidayu Ali, Siti Zawahir Zubir, Sarina Ramli, Hamizah Husain, Azizah Ahmad High Impact Research Annual Report 2012 UM HIR ADVISORY COUNCIL To ensure the success of HIR, the Chairman has appointed several distinguished scientists as-members of the UM HIR Advisory Council. Council members advise the university in matters related to research priority, as well as facilitating joint research between their own institutions and the University of Malaya. To date, three UM Nobel Fellows and one Distinguished Fellow have been appointed and the brief profile of each member is provided. Nobel Fellow Barry Marshall (Nobel Prize in Physiology or Medicine, 2005) Prof. Barry Marshall is Professor of Clinical Microbiology at the University of Western Australia. His work in proving that the bacterium Helicobacter pylori is the cause of most peptic ulcers earned him and his long-term collaborator, Robin Warren, the 2005 Nobel Prize in Physiology. In honour of Prof. Marshall winning the Nobel Prize, UWA set up The Marshall Centre in 2007 to perform world-class infectious diseases research and disease surveillance. Nobel Fellow Ryoji Noyori (Nobel Prize in Chemistry, 2001) Prof. Ryoji Noyori is President of RIKEN, one of Japan’s largest research organizations with more than 3,000 scientists. He is also Professor in the Department of Chemistry and Research Center for Materials Science at Nagoya University. He shared the 2001 Nobel Prize in Chemistry with William S. Knowles for the study of chirally catalyzed hydrogenations. Nobel Fellow David Baltimore (Nobel Prize in Physiology or Medicine, 1975) Prof. David Baltimore is currently the Robert A. Millikan Professor of Biology at the California Institute of Technology. In 1975, at the age of 37, he shared the Nobel Prize in Physiology or Medicine with Howard Temin and Renato Dulbecco for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell. Distinguished Fellow Rita Colwell Prof. Rita Colwell is Distinguished University Professor at the University of Maryland at College Park and at Johns Hopkins University Bloomberg School of Public Health, USA. She is currently US President Science Envoy to the Asia Pacific. Her research interests focus on global infectious diseases and she is currently developing an international network to address emerging infectious diseases and water issues. Distinguished Fellow Wong Chi-Huey Professor Wong Chi-Huey, President of Academia Sinica, Taiwan, is the holder of many international appointments and sits on the editorial boards of Editorial Advisory Board member for the Journal of American Chemical Society, Angewandte Chemie, Advanced Synthesis and Catalysis, and Current Opinion in Chemical Biology. He is also a member of Board of Scientific Governors of the Scripps Research Institute, the Steering Committee of the Lilly TB Drug Discovery Initiative, and the Chief Science Advisor of the Ministry of Science, Taiwan. 13 14 High Impact Research Annual Report 2012 HIR BACKGROUND SUMMARY OF PROJECTS 2012 INTERNATIONAL COLLABORATORS 16 High Impact Research Annual Report 2012 HIR BACKGROUND The high impact research grants from the University of Malaya are to fund projects which will result in publication of manuscripts in Tier 1 ISI/Web of Science journals. As such, the emphasis is on fundamental research which will lead to the generation of new knowledge rather than on the development of new products or patents. It is also aimed at generating more research capa-bilities and expertise within the university and this may result from collaboration with overseas ivy-league universities. These grants are handled differently from all existing grants and are administered under the Chancellery. The Vice-Chancellor is the Chairman of the High Impact Research Committee which will evaluate the projects, decide on its suitability for funding and monitor their progress. Recognizing the importance of UM as the premier research institution in the country, the gov-ernment made the bold decision to provide additional research funding to UM, with the objective of having at least one research university in the country breaking into the top 100 world ranked universities by 2015. In August 2011, the Ministry of Higher Education (MoHE) injected RM590 million into the UM-MoHE HIR programme. The infusion of MoHE’s additional research fund provided the opportunity for researchers to undertake more ambitious research over a longer period of time. Thus, the original Chancellory HIR programme, funded modestly using internal funds, becomes less attractive for seasoned researchers. Nevertheless, it is felt that it should not be dropped completely as it can still serve a role for projects which are more focussed and targeted to be completed within 2 years. The Central (Chancellory) HIR Committee, chaired by Tan Sri VC, decided that in 2012, there will be only 2 instead of 4 cycles. The target set are still Tier 1 publications with the cost-target of RM60,000 per publication. The maximum amount of funding is RM500,000 for 2 years and lecturers who are not receiving MoHE funding will be given preference. SUMMARY OF PROJECTS 2012 PROJECTS BY YEAR (HIR-MoHE) BUDGET (OVERALL) No PTj Year 2012 (RM) Year 2013 (RM) Year 2014 (RM) Year 2015 (RM) Overall No of Project 1 MEDICINE 15,111,000 1,820,000 2 ENGINEERING 27,341,280 16,270,020 1,143,000 603,800 18,677,800 5 12,802,900 8,693,920 65,108,120 27 3 SCIENCE 0 0 0 0 0 0 4 DENTAL 6,279,930 3,456,729 2,873,206 2,482,486 15,092,351 13 5 COMPUTER SCIENCE 1,218,500 940,100 772,100 270,500 3,201,200 6 6 CHANCELLORY 3,171,750 2,902,500 177,000 38,000 6,289,250 2 Total Per Year : 53,122,460 25,389,349 17,768,206 12,088,706 108,368,721 53 Year 2015 (RM) Overall (Equipment) Overall (Budget for 5 years) Percentage % (Overall for 5 years / Overal Equipmments) BUDGET (EQUIPMENT) No PTj Year 2012 (RM) Year 2013 (RM) Year 2014 (RM) 1 MEDICINE 11,300,000 0 0 0 11,300,000 18,677,800 60.5 2 ENGINEERING 15,727,930 4,667,000 1,920,000 496,000 22,810,930 65,108,120 35.0 3 SCIENCE 0 0 0 0 0 0 0 4 DENTAL 2,871,000 20,000 15,000 0 2,906,000 15,092,351 19.3 5 COMPUTER SCIENCE 330,600 11,000 0 0 341,600 3,201,200 10.7 6 CHANCELLORY 1,892,000 1,680,000 15,000 0 3,587,000 6,289,250 57.0 Total Per Year: 32,121,530 6,378,000 1,950,000 496,000 40,945,530 108,368,721 37.8 High Impact Research Annual Report 2012 BUDGET (OPEX) No PTj Year 2012 (RM) Year 2013 (RM) Year 2014 (RM) Year 2015 (RM) Overall (Opex) Overall (Budget for 5 years) Percentage % (Overall for 5 years / Overal Opex) 1 MEDICINE 3,811,000 1,820,000 1,143,000 603,800 7,377,800 18,677,800 39.5 2 ENGINEERING 11,613,350 11,603,020 10,882,900 8,197,920 42,297,190 65,108,120 65.0 3 SCIENCE 0 0 0 0 0 - 0 4 DENTAL 3,408,930 3,436,729 2,858,206 2,482,486 12,186,351 15,092,351 80.7 5 COMPUTER SCIENCE 887,900 929,100 772,100 270,500 2,859,600 3,201,200 89.3 6 CHANCELLORY 1,279,750 1,222,500 162,000 38,000 2,702,250 6,289,250 43.0 Total Per Year : 21,000,930 6,378,000 1,950,000 496,000 67,423,191 108,368,721 62.2 Tier 1 ISI Bright Sparks Academic Icon Patent KPI PTj MEDICINE 59 6 0 0 ENGINEERING 594 69 27 64 SCIENCE 0 0 0 0 DENTAL 94 1 1 3 COMPUTER SCIENCE 28 1 1 2 CHANCELLORY 31 0 0 5 Total KPI : 806 77 29 74 PROJECTS BY FIELD OF RESEARCH BUDGET (OVERALL) No PTj 1 MEDICINE 2 ENGINEERING 3 Overall No of Project 339,000 5 3,190,000 27 SCIENCE 0 0 4 DENTAL 5,927,125 13 5 COMPUTER SCIENCE 349,000 6 6 CHANCELLORY 5,190,000 2 Total Per Year : 14,995,125 53 17 High Impact Research Annual Report 2012 HIR PUBLICATIONS IN ISI JOURNALS (HIR MoHE PROJECT) MoHE HIR PUBLICATIONS (2011 & 2012) 140MoHE HIR PUBLICATIONS (2011 & 2012) NO OFNO PUBLICATIONS OF PUBLICATIONS 120 140 100 120 80 100 60 80 40 60 20 40 200 MEDICINE 0 ENGINEERING MEDICINE SCIENCE ENGINEERING DENTAL SCIENCE COMPUTER SCIENCE DENTAL CHANCELLORY COMPUTER SCIENCE CHANCELLORY Tier 1 Tier 2 Tier 3 Tier 4 70 Tier 1 127 70 97 127 9 97 30 9 108 20 Tier 2 16 20 34 16 12 Tier 3 5 12 16 5 12 Tier 4 6 12 11 6 34 16 11 16 8 24 108 16 8 24 30 HIR MoHE PUBLICATIONS (2011) HIRMoHE MoHEPUBLICATIONS PUBLICATIONS(2011) (2011) HIR MoHE HIR PUBLICATIONS 2011 30 MoHE HIR PUBLICATIONS 2011 30 25 NO OF NO PUBLICATIONS OF PUBLICATIONS 18 25 20 20 15 15 10 105 50 Tier 1 Tier 2 Tier 3 Tier 4 20 Tier 28 1 11 Tier 4 2 4 Tier 0 3 20 24 28 1 11 10 4 44 0 6 Tier 4 4 36 24 10 4 3 DENTAL CHANCELLORY COMPUTER SCIENCE 1 19 6 3 15 CHANCELLORY 19 6 3 15 MEDICINE ENGINEERING MEDICINE SCIENCE 0 ENGINEERING DENTAL SCIENCE COMPUTER SCIENCE 4 High Impact Research Annual Report 2012 MoHE PUBLICATIONS (2012) HIRHIR MoHE PUBLICATIONS (2012) HIR MoHE PUBLICATIONS (2012) 120 MoHE HIR PUBLICATIONS 2012 MoHE HIR PUBLICATIONS 2012 NO OFNO PUBLICATIONS OF PUBLICATIONS 120 100 MEDICINE ENGINEERING MEDICINE SCIENCE ENGINEERING DENTAL 100 80 80 60 60 40 40 20 200 0 SCIENCE COMPUTER SCIENCE DENTAL CHANCELLORY COMPUTER SCIENCE Tier 1 Tier 2 Tier 3 Tier 4 50 Tier 991 9 Tier 12 2 8 Tier 15 3 6 Tier 2 4 86 73 30 889 24 12 8 10 5 9 50 73 99 8 9 24 12 30 8 12 15 2 89 5 HIR CHANCELLORY PUBLICATIONS IN ISI JOURNALS (HIR 210 YEARS PROJECT) 9 HIR PUBLICATIONS IN ISI JOURNALS (HIR 2 YEARS PROJECT) HIR-CHANCELLORY CYCLE HIR PUBLICATIONS INPUBLICATIONS ISI JOURNALSBY (HIR 2 YEARS PROJECT) 2010 PROJECT HIR-CHANCELLORY PUBLICATIONS BY CYCLE HIR-CHANCELLORY PUBLICATIONS BY CYCLE 2010 PROJECT 2010 PROJECT HIR-CHANCELLORY PROJECTS 2010 NO OF PUBLICATIONS NO OF PUBLICATIONS 50 45 50 40 45 35 40 30 35 25 30 20 25 15 20 10 155 100 5 2010 0 2011 TOTAL PUBLICATIONS HIR-CHANCELLORY PROJECTS 2010 TOTAL PUBLICATIONS Tier 1 Tier 2 6 8 Tier 3 Tier 4 Tier7 2 13 8 2 3 Tier 2 3 4 Tier 1 2012 2010 151 Tier 646 2011 15 7 2 3 2012 46 13 2 1 19 PUBLICATIONS NONO OFOF PUBLICATIONS High Impact Research Annual Report 2012 20 20 18 18 16 16 14 14 12 12 10 10 8 8 6 6 4 4 2 2 0 0 2010 2010 2011 2011 2012 2012 16 16 HIR-CHANCELLORY PUBLICATIONS CYCLE 1 HIR-CHANCELLORY PUBLICATIONS CYCLE 1 Tier 1 Tier 1 Tier 2 Tier 2 1 1 19 19 4 4 Tier 3 Tier 3 Tier 4 Tier 4 HIR-CHANCELLORY HIR-CHANCELLORY PUBLICATIONS PUBLICATIONS CYCLE CYCLE22 14 14 NOOFOFPUBLICATIONS PUBLICATIONS NO 12 12 10 10 8 8 6 6 4 4 2 2 0 0 2010 2010 2011 2011 2012 2012 Tier 1 Tier 1 2 2 3 3 15 15 Tier 2 Tier 2 6 6 Tier 3 Tier 3 Tier 4 Tier 4 1 1 1 1 4 4 HIR-CHANCELLORY PUBLICATIONS CYCLE 3 7 6 NO OF PUBLICATIONS 20 5 4 3 2 1 0 Tier 1 Tier 2 2010 4 2 2011 2 2012 6 Tier 3 HIGH RESEARCH REPORT 2012 16 HIGHIMPACT IMPACT RESEARCHANNUAL ANNUAL 6 1 REPORT 2012 16 2 5 1 HIR-CHANCELLORY PUBLICATIONS CYCLE 4 9 Tier 4 2011 2 6 1 2012 6 5 1 2 High Impact Research Annual Report 2012 HIR-CHANCELLORY PUBLICATIONS CYCLE 4 9 8 NO OF PUBLICATIONS 7 6 5 4 3 2 1 0 Tier 1 Tier 2 Tier 3 2011 8 1 1 2012 7 3 1 Tier 4 2010 HIR PUBLICATIONS IN ISI JOURNALS (HIR 2 YEARS PROJECT) HIR PUBLICATIONS 2011 HIRPROJECT PUBLICATIONS IN ISI JOURNALS (HIR 2 YEARS PROJECT) HIR-CHANCELLORY PROJECTS 2011 HIR-CHANCELLORY PROJECTS 2011 TOTAL PUBLICATIONS 18 16 NO OF PUBLICATIONS 14 12 10 HIGH IMPACT RESEARCH ANNUAL REPORT 2012 17 8 6 4 2 0 Tier 1 Tier 2 Tier 3 Tier 4 2010 2011 3 2012 17 1 HIR-CHANCELLORY PUBLICATIONS CYCLE 1 6 1 21 2011 3 High Impact Research 2012 Annual Report 17 2012 1 1 HIR-CHANCELLORY PUBLICATIONS CYCLE 1 NO OF PUBLICATIONS 6 5 4 3 2 1 0 Tier 1 Tier 2 5 1 Tier 3 Tier 4 2010 2011 2012 1 HIR-CHANCELLORY PUBLICATIONS CYCLE 2 7 NO OF PUBLICATIOS 6 5 4 HIGH IMPACT RESEARCH ANNUAL REPORT 2012 18 3 2 1 0 Tier 1 Tier 2 Tier 3 2010 2011 2 2012 6 HIR-CHANCELLORY PUBLICATIONS CYCLE 3 4.5 4 BLICATIONS 22 3.5 3 2.5 Tier 4 2011 2 2012 6 High Impact Research Annual Report 2012 HIR-CHANCELLORY PUBLICATIONS CYCLE 3 4.5 NO OF PUBLICATIONS 4 3.5 3 2.5 2 1.5 1 0.5 0 Tier 1 Tier 2 Tier 3 Tier 4 2010 2011 1 2012 4 HIR-CHANCELLORY PUBLICATIONS CYCLE 4 NO OF PUBLICATIONS 2.5 2 1.5 1 0.5 0 Tier 1 Tier 2 Tier 3 Tier 4 2010 2011 2012 2 HIGH IMPACT RESEARCH ANNUAL REPORT 2012 19 *Updated 31 December December 2012 *Updated asasofof31 2012 23 24 High Impact Research Annual Report 2012 INTERNATIONAL COLLABORATION USA Canada UK USA France Iran UAE Kuwait China Korea Japan Bangladesh Thailand Singapore Indonesia Australia New Zealand Australaisia Europe 1. Monash University, Australia 22. Cardiff University, United Kingdom 2. Royal Melbourne Institute of Technology, Melbourne, Australia 23. Imperial College, United Kingdom 3. The Prince Charles Hospital, Brisbane, Australia 25. King’s London College, United Kingdom 4. The University of Adelaide, Australia 26. Lancaster University, United Kingdom 5. The University of Sydney, Australia 27. Loughborough University, United Kingdom 6. University of Melbourne, Victoria 28. University College London United Kingdom 7. University of New South Wales, Sydney, Australia 29. University of Birmingham, United Kingdom 8. University of Wollongong, Australia 30. University of Cambridge, United Kingdom Bangladesh 9. Bangladesh University of Engineering and Technology Canada 10. Ryerson University, Canada 11. University of Alberta Edmonton, AB Canada 12. University of Calgary, Canada 13. University of Ottawa, Canada 24. Karolinska Institutet, Solna, Stockholm, Sweden 31. University of Edinburgh United Kingdom 32. University of Kingston, United Kingdom 33. University of Liverpool, United Kingdom 34. University of London, United Kingdom 35. University of Manchester, United Kingdom 36. University of Newcastle, United Kingdom 37. University of Oxford, United Kingdom 38. University of Plymouth United Kingdom 39. University of Southampton, United Kingdom China 40. University of Southampton, United Kingdom 14. Chinese University of Hong Kong 41. University of Ulster, United Kingdom 15. Dalian University of Technology , China 42. Queen’s University Belfast, United Kingdom 16. National Cheng Kung University, Taiwan 17. National Taiwan University 18. Shanghai Jiao Tong University, Shanghai, China France 43. Université Paris 1 Panthéon-Sorbonne 19. The Hong Kong Polytechnic University Indonesia 20. University of Kansas.Taiwan 44. Gadjah Mada University, Indonesia 21. University Rd., Jinning, Kinmen, Taiwan 45. Mataram University, Indonesia High Impact Research Annual Report 2012 Iran New Zealand 46. Kharazmi University, Iran 65. University of Otago, New Zealand 47. Razi University, Iran 66. University of Waikato, Hamilton, New Zealand 48. University of Tehran, Iran Singapore Japan 67. National University of Singapore, Singapore 49. Hiroshima University, Japan 68. Singapore Immunology Network, A*Star 50. Hokkaido University, Japan 51. Keio University, Japan 52. Kumam University of Tokyo, Japan 53. Kyoto University of Education, Japan 54. Kyushu University, Japan 55. Masanobu Satake, Tohoku University, Japan 56. Multimedia University, Japan 57. Nagaoka University of Technology, Japan 58. RIKEN Center for Genomic Medicine, Japan 59. Tohoku University, Japan. 60. Tokyo Institute of Technology, Japan 61. Tokyo Metropolitan University, Japan 62. Yamaguchi University, Japan Korea 63. Institute of Science and Technlogy, Gusongdong,Yuseong-gu, Korea Kuwait 64. Kuwait University, Kuwait Thailand 69. Mahidol University, Thailand United Arab Emirates 70. University, Al Ain, United Arab Emirates United States 71. Centers For Disease Control, Atlanta, USA. 72. Emory University, Atlanta, USA. 73. National Institutes of Health, USA 74. Origin State University, USA 75. University of California, Davis, USA 76. University of Miami 77. University of Michigan, Dearborn, USA 78. University of Pittsburgh School of Public Health, USA 79. University of South Florida USA 80. University of Wisconsin-Madison United States 81. University School Of Medicine, USA. 82. Wayne State University, USA 25 26 High Impact Research Annual Report 2012 POSTGRADUATED STUDENTS (2011) HIR-MoHE (5 YEAR PROJECTS) POSTGRADUATED STUDENTS (2011) HIR-MoHE (5YEAR PROJECTS) MASTERS STUDENTS 2011 30 25 20 15 10 5 0 MEDICINE MEDICINE ENGINEERING SCIENCE Completed Research Assistant Local International 11 4 COMPUTER SCIENCE DENTISTRY CHANCELLORY Ongoing Research Assistant Local International 28 7 ENGINEERING 2 0 24 18 SCIENCE 3 5 16 2 DENTISTRY 6 0 4 0 COMPUTER SCIENCE 0 0 4 3 CHANCELLORY 6 8 26 1 High Impact Research Annual Report 2012 Local Students 50 45 40 35 30 25 20 15 10 5 0 International Students Local Students International Students PHD STUDENTS 2011 Engineering Science Dental Computer Science Chancellory Medicine Research Assistant Ongoing Research Assistant Completed Medicine Completed Research Assistant Local Students International Students 0 1 Ongoing Research Assistant Local Students International Students 31 7 Engineering 0 3 18 50 Science 1 0 20 14 Dental 0 0 4 1 Computer Science 0 0 0 16 Chancellory 2 0 8 9 MoHE HIR Post Doc 2011 9 8 7 6 5 4 3 2 1 0 HIGH IMPACT RESEARCH ANNUAL REPORT 2012 25 Medicine Engineering Science Dental HIR Post Doc Local 9 2 1 3 HIR Post Doc International 2 1 1 1 Computer Chancellory Science 1 4 3 1 27 28 High Impact Research Annual Report 2012 POSTGRADUATED STUDENTS BY YEAR (2012) POSTGRADUATE STUDENTS BY YEAR (2012) HIR-MoHE (5 YEAR PROJECTS) HIR-MoHE (5YEAR PROJECTS) MASTERS STUDENTS 2012 50 45 40 35 30 25 20 15 10 5 0 MEDICINE MEDICINE ENGINEERING SCIENCE Completed Research Assistant Local International 8 3 DENTISTRY COMPUTER SCIENCE CHANCELLORY Ongoing Research Assistant Local International 28 5 ENGINEERING 2 6 24 SCIENCE 9 8 40 3 DENTISTRY 0 0 2 2 49 COMPUTER SCIENCE 0 0 3 2 CHANCELLORY 14 10 40 2 High Impact Research Annual Report 2012 PHD Student 2012 Student 2012 35 35 30 30 25 25 20 20 Research Assistant Research Assistant Research Assistant Research Assistant 15 15 10 10 Ongoing Ongoing Completed Completed 2011 2011 Medicine Medicine Engineering Engineering Science Science Dental Computer Science Dental Chancellory Computer Science Chancellory Computer Science Chancellory Computer Science Dental Dental Completed Completed Research Assistant Research Assistant 0 06 Chancellory Science Science 2011 2011 Medicine Medicine Engineering Engineering 0 10 Ongoing Ongoing Research Assistant Research 0 Assistant 260 63 30 00 00 00 01 10 2026 1520 01 515 0 11 0 25 7 0 0 82 5 7 0 0 8 5 0 11 0 35 11 11 35 MoHE HIR Post Doc 2012 MoHE HIR Post Doc 2012 7 7 6 5 6 4 5 3 4 2 3 1 2 0 1 0 Medicine Medicine HIR Post Doc International Engineering Engineering Science Science Dental Dental Computer Science Computer Science HIR Post Doc Local HIR Post Doc International Chancellory Chancellory Medicine Engineering Science 0 Medicine 0 0 Engineering 3 0 Science 2 2 Dental 0 HIR Post Doc Local 0 0 0 2 HIR Post Doc International 0 3 2 0 HIR Post Doc Local HIR Post Doc International HIR Post Doc Local Dental Computer Science 1 Computer 0 Science 1 HIGH IMPACT RESEARCH ANNUAL REPORT 2012 28 HIGH IMPACT RESEARCH ANNUAL REPORT 2012 28 0 Chancellory 7 Chancellory 0 7 0 5 5 0 0 29 High Impact Research Annual Report 2012 POSTGRADUATED STUDENTS HIR 2 YEARS PROJECT (2010) POSTGRADUATE STUDENTS HIR 2 YEARS PROJECT (2010) MASTERS STUDENTS 2010 25 20 15 10 Research Assistant Project Assistant Research Assistant Ongoing Local International Local International Local International Local 5 International CYCLE 1 CYCLE 1 CYCLE 2 CYCLE 3 CYCLE 4 Project Assistant Completed Completed Project Assistant Research Assistant Local International Local International 1 Ongoing Project Assistant Research Assistant Local International Local International 2 4 CYCLE 2 24 CYCLE 3 3 5 CYCLE 4 1 8 PHD STUDENTS 2010 14 12 10 8 6 4 Research Assistant Project Assistant Ongoing CYCLE 1 Research Assistant Local Students International Students Local Students International Students Local Students International Students Local Students 2 International Students 30 CYCLE 4 CYCLE 3 Project Assistant Completed Completed Ongoing Project Assistant Research Assistant Project Assistant Research Assistant Local International Local International Local International Local International Students Students Students Students Students Students Students Students HIGH IMPACT RESEARCH ANNUAL REPORT 2012 29 1 1 1 3 2 CYCLE 2 CYCLE 3 CYCLE 4 CYCLE 1 CYCLE 2 6 2 2 3 4 13 4 6 4 0 0 High Impact Research Annual Report 2012 HIR POST DOC 2010 4 HIR POST DOC 2010 3.5 3 2.5 2 4 1.5 3.5 1 3 0.5 2.5 2 0 1.5 1 CYCLE 2 Local 0 CYCLE 2 Local Doc 1 International HIR Post CYCLE Local HIR Post Doc 1 CYCLE 1 CYCLE 2 3 CYCLE 3 4 Local CYCLE 4 CYCLE 1 International HIR Post Doc 0.5 CYCLE 4 CYCLE 3 HIR Post Doc CYCLE 4 CYCLE 3 International 2 2 1 International 1 2 3 2 CYCLE 3 4 1 CYCLE 4 1 2 CYCLE 1 1 CYCLE 2 2 POSTGRADUATED STUDENTS POSTGRADUATE STUDENTS HIR 2 YEARS PROJECTS (2011) POSTGRADUATE STUDENTS HIR 2 YEARS HIRPROJECT 2 YEARS (2011) PROJECTS (2011) MASTERS STUDENTS 2011 International Local International Local International Local International International Local International Local Local International International MASTERS STUDENTS 2011 CYCLE 4 CYCLE 4 CYCLE 2 CYCLE 3 CYCLE 1 CYCLE 2 CYCLE 3 CYCLE 1 Research ResearchResearch ProjectProjectResearch Assistant Assistant AssistantAssistant Assistant Assistant OngoingOngoing Research Assistant International Research LocalAssistant International International Local 3 International CYCLE 1 CYCLE 1 CYCLE 2 CYCLE 2 CYCLE 3 3 CYCLE 3 CYCLE 4 2 CYCLE 4 1 1 1 2 1 1 Ongoing Ongoing Research Assistant Project Assistant Project ResearchInternational Assistant Local Assistant International Local Local7 International Local International 1 7 2 2 2 2 1 8 18 1 1 HIGH IMPACT RESEARCH ANNUAL REPORT 2012 31 3 3 8 7 6 5 4 3 2 1 0 8 7 6 5 4 3 2 1 0 31 PHD STUDENT 2011 High Impact Research Annual Report 2012 20 Ongoing Research Assistant Project Assistant Ongoing International CYCLE 1 CYCLE 2CYCLE 1 Local International International Local International International Local Project Assistant Local International International Research Assistant Local International Local PHD STUDENT 2011 International 32 Research Assistant Research Assistant Research Assistant Local International Research Assistant Local International International CYCLE 3CYCLE 2 15 5 10 0 0 Ongoing Project Assistant Research Assistant Ongoing Local International Local International Project Research7Assistant 4 Assistant 3 Local 44 International Local 7 4 CYCLE 4CYCLE 3 CYCLE 4 15 5 CYCLE 1 CYCLE 2 CYCLE 3 CYCLE 4 10 CYCLE 1 CYCLE 2 CYCLE 3 CYCLE 4 20 8 8 7 International 3 7 2 2 16 16 6 6 9 9 HIR-CHANCELLORY POSTDOC 2011 HIR-CHANCELLORY POSTDOC 2011 3 3 2 2 1 1 0 0 CYCLE 2 CYCLE 1 CYCLE 1 CYCLE 2 CYCLE 3 CYCLE CYCLE 1 4 CYCLE 2 CYCLE 1 Local 3 1 Local 1 32 1 HIR Post Doc CYCLE 2 HIR Post Doc CYCLE 4 CYCLE 3 CYCLE 4 CYCLE 3 International 1 3 International 1 1 0 3 CYCLE 3 1 0 CYCLE 4 2 1 *Updated as of 31 December 2012 HIGH IMPACT RESEARCH ANNUAL REPORT 2012 32 HIGH IMPACT RESEARCH ANNUAL REPORT 2012 32 LIST OF PUBLICATIONS HIR MOHE LIST OF PRESENTATIONS HIR MOHE 2012 LIST OF SUCCESSFUL APPLICANTS 2012 34 High Impact Research Annual Report 2012 LIST OF PUBLICATIONS HIR MOHE 2012 BY FACULTY FACULTY OF MEDICINE 1. Lim A, Amini A, D’Orsogna LJ, Rajasuriar R, Kramski M, Lewin SR, Purcell DF, Price P, French MA.(2011)Antibody And B Cell Responses May Control Circulating Lipopolysaccharide In Patients With HIV Infection, AIDS. 2011 Jul 17;25(11):1379-83. 2. Tan DBA, Lim A, Yong YK, Ponnampalavanar S, Omar S, Kamarulzaman A, French MA (2011)TLR2-Induced Cytokine Responses May Characterize HIV-Infected Patients Experiencing Mycobacterial Immune Restoration Disease., Price P. AIDS. 2011 Jul 31; 25(12): 1455-60. 3. 4. 5. 6. Sungkanuparph S, Oyomopito R, Sirivichayakul S, Sirisanthana T, Li PCK, Kantipong P, Lee CKC, Kamarulzaman A, Messerschmidt L, Law MG, Phanuphak P (2011). HIV-1 Drug Resistance Mutations Among Antiretroviral-Naïve Hiv-1Infected Patients In Asia: Results From The Treat Asia Studies To Evaluate ResistanceMonitoring Study.; on behalf of the TREAT Asia Studies to Evaluate Resistance-Monitoring Study (TASER-M). Clin Infect Dis. 2011 Apr;52(8):10531057. Lau YL, Tan LH, Chin LC, MY Fong, Noraishah MA, Rohela M (2011). Plasmodium Knowlesi Re-Infection In Human. Emerging Infectious Diseases. 17 (7): 1314-15 Yee-Ling Lau, Mun-Yik Fong, Rohela Mahmud, Phooi-Yee Chang, Vanitha Palaeya, Fei-Wen Cheong, Lit-Chein Chin, Claudia N Anthony, Abdulsalam MQ Al-Mekhlafi And Yeng Chen. (2011) Specific, Sensitive And Rapid Detection Of Human Plasmodium Knowlesi Infection By Loop-Mediated Isothermal Amplification (LAMP) In Blood Samples. Malaria Journal. 10:197 Open access Mariappan V, Vellasamy KM, Hashim OH, Vadivelu J. Profiling of Burkholderia cepacia secretome at mid-logarithmic and earlystationary phases of growth. Plos One (2011); 6 (10): e26518. doi: 10.1371/journal.pone.0026518 7. Mokhtar AS, Tay ST. Molecular detection of Rickettsia felis, Bartonella henselae, and B. clarridgeiae in fleas from domestic dogs and cats in Malaysia. Am J Trop Med Hyg. 2011 85(5):931-3. 8. Phooi Yee Chang, Mun Yik Fong, Veeranoot Nissapatorn, Yee Ling Lau. (2011). Evaluation of Pichia-expressed recombinant rhoptry protein 2 (ROP2) of Toxoplasma gondii towards its application in diagnosis of toxoplasmosis.. American Journal of Tropical Medicine And Hygiene 85(3): 485–489 9. Sui-Ting Lee; Pooi-Fong Wong; Shiau-Chuen Cheah; Mohd Rais Mustafa. 2011. AlphaTomatine Induces Apoptosis and Inhibits Nuclear Factor-Kappa B Activation on Human Prostatic Adenocarcinoma PC-3 Cell. PLoS ONE 6(4): e18195 (ISI-Cited Publication) 10. Mohamed EHM, Tan KS,Mohd Ali J, Mohamed Z.TT genotype of the methylenetetrahydrofolate reductase C677T polymorphism is an important determinant for homocysteine levels in multiethnic Malaysian ischaemic stroke patients. Ann Acad Med Singapore 2011;40:186-191 (ISI-Cited Publication) 11. BS Haerian, H Roslan, AA Raymond, CT Tan, KS Lim, SZ Zulkifli, EHM Mohamed, HJ Tan and Z Mohamed. Association of ABCB1 gene polymorphisms and their haplotypes with response to antiepileptic drugs: A systematic review and meta-analysis. Pharmacogenomics 2011:12(5); 713-725. (DOI: 10.2217/PGS.10.212) (Impact Factor = 4.398; Tier 1). (ISI-Cited Publication) 12. EHM Mohamed, KS Tan, JM Ali, Z Mohamed. TT genotype of the methylenetetrahydrofolate reductase C677T polymorphism is an important determinant for homocysteine levels in multi-ethnic Malaysian ischaemic stroke patients. Annals Academy of Medicine. 2011. 40(4);186-191(Impact Factor = 1.01) (ISI-Cited Publication) 13. BS Haerian, H Roslan, AA Raymond, CT Tan, KS Lim, SZ Zulkifli, EHM Mohamed, HJ Tan and Z Mohamed. Lack of association of ABCB1 and PXR polymorphisms with response to treatment in epilepsy. Seizure 2011. 20 (5): 387394. (Impact Factor = 2.233; Tier 3) (ISI-Cited Publication) 14. BS Haerian, H Roslan, AA Raymond, CT Tan, KS Lim, SZ Zulkifli, EHM Mohamed, HJ Tan and Z Mohamed. Association of ABCB1 polymorphisms with response to sodium valproate treatment in Malaysian epilepsy patients. Epileptic Disorders 2011; 13(1): 65-75 (Impact Factor = 1.26). (ISI-Cited Publication) 15. Ching-Lee Wan, Nor Zuraida Zainal, Lay-Hoong Lian, Zahurin Mohamed. Association of the functional polymorphism in the Catechol-OMethyltranferase gene with schizophrenia in the three ethnic groups of the Malaysian population. Psychiatry Research 2011; 189(1): 67-71 (Impact Factor = 2.373). http://dx.doi.org/10.1016/j. psychres.2011.02.008 (ISI-Cited Publication) 16. BS Haerian, KS Lim, EHM Mohamed, HJ Tan, CT Tan, AA Raymond, CP Wong, SW Wong, and Z Mohamed. Lack of association between synapsin II (SYN2) gene polymorphism and susceptibility epilepsy: A case control study and meta-analysis. Synapse 2011; 65(10): 1073-79. (Impact Factor = 2.557: Tier 3 Publication). (ISICited Publication) 17. BS Haerian, KS Lim, EHM Mohamed, HJ Tan, CT Tan, AA Raymond, CP Wong, SW Wong, and Z Mohamed. Lack of association of ABCB1 haplotypes on five loci with response to High Impact Research Annual Report 2012 treatment in epilepsy. Seizure 2011; 20 (7); 546553. DOI: 10.1016/j.seizure.2011.04.003 (Impact Factor = 2.233: Tier 3 Publication). (ISI-Cited Publication) 18. Zain, SM; Mohamed, Z; Mahadeva, S; et al. Does polymorphism in patatin-like phospholipase 3 gene (PNPLA3) confer risk of nonalcoholic fatty liver disease (NAFLD) in multiethnic Malaysian population? Drug Metabolism Reviews Volume: 43 Pages: 56-57 Published: MAY 2011 (ISI-Cited Publication) 19. Zain, MAM; Zainal, NZ; Kanagasundram, S; Mohamed, Z Association between PDLIM5 gene and bipolar disorder in Malaysian population. Drug Metabolism Reviews 2011 May. 43:57-57 (ISI-Cited Publication) 20. Mohamed, Z; Haerian, BS; Lim, KS; et al. Association of ABCB1 polymorphisms with response to sodium valproate in Malaysian epilepsy patients.Drug Metabolism Reviews 2011 May. 43:80-81 (ISI-Cited Publication) 21. Kong WM, Chik Z, Ramachandra M, Subramaniam U, Aziddin RER and Mohamed Z. Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay. Molecules 2011, 16, 7344-7356; doi:10.3390/molecules16097344 (Tier 2; Impact Factor 1.988) (ISI-Cited Publication) 22. Zahurin Mohamed, Zuraida Zainal, Lay Hoong Lian and Ai Chin Loke. Association Study of Tryptophan Hydroxylase 2 and Serotonin Transporter Genes with Major Depressive Disorder in Malaysian Ethnic Subgroups. Clinical Psychopharmacology and Neuroscience 2011;9 (1):40-40. (SCOPUS-Cited Publication) 23. Yamunah Devi Apalasamy, Moy Foong Ming, Sanjay Rampal, Awang Bulgiba and Zahurin Mohamed. Gender-Dependent Association of a Beta2-adrenergic Gene variant With Obesity Parameters in Malaysian Malays. Asia Pacific Journal of Public Health. Oct 2011. (ISI-Cited Publication) 24. Sundaram C, Shankar SK, Thong WK, PardoVillamizar CA. Pathology and diagnosis of central nervous system infections. Pathology Research International 2011, Article ID878263, 4 pages, doi:10.4061/2011/878263 25. Wong, K. T., and K. C. Ong. 2011. Pathology of acute henipavirus infection in humans and animals. Patholog Res Int 2011:567248. 26. Nazir R, Mazhar M, Wakeel T, Akhtar MJ, Siddique M, Nadeem M, Khan NA, Shah R. Pyrolysis Mechanism of Trisbipyridineiron(II) Chloride to Iron Nanoparticles. J. Therm Anal Calorim (2011) DOI:10.1007/s10973-011-1919-5 27. Nazir R, Mazhar M, Wakeel T, Akhtar MJ, Siddique M, Nadeem M, Khan NA, Shah R. Pyrolysis Mechanism of Trisbipyridineiron(II) Chloride to Iron Nanoparticles. J. Therm Anal Calorim (2011) DOI:10.1007/s10973-011-1919-5 28. Kheng Seang Lim, Chin Hwan Lim, Chong Tin Tan. Attitudes toward epilepsy, a systematic review. Neurology Asia 2011; 16(4) : 269 – 280 29. Lau YL, Tan LH, Chin LC, MY Fong, Noraishah MA, Rohela M (2011). Plasmodium Knowlesi Re-Infection In Human. Emerging Infectious Diseases. 17 (7): 1314-15 30. Lee, M.L., Tan, N.H., Fung, S.Y. and Shamala, D.S. (2011). Antibacterial action of a heat-stable form of L-amino acid oxidase isolated from king cobra (Ophiophagus hannah) venom. Comp. Biochem. Physiol. C. 153, 237-242. 31. Omar NA, Abdullah N, Kuppusamy UR, Abdulla MA, Sabaratnam V. 2011. Nutritional comparison, antioxidant activities and antiulcer potential of Lentinus squarrosulus (Mont.) mycelia extract. Evidence Based complementary and Alternative Medicine.DOI: 10.1155/2011/539356 32. Rajarajeswaran J, MS Kanthimathi. 2011. Inhibitory effects of fruit extracts on nitric oxide-induced proliferation in MCF-7 cells. Food Chemistry 126:956-960. 33. Ng ZX, Kuppusamy UR, Tajunisah I, Choong KSF, Choon AAK, Chua KH. 2011. 2245G/A polymorphism of the receptor for advanced glycation end-products (RAGE) gene is associated with diabetic retinopathy in the Malaysian population. Bri J Ophthal. DOI: 10.1136/bjothalmol-2011-300658 34. Leong KH, Chung LY, Noordin MI, Onuki Y, Morishita M, Takayama K. Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery. Carb Polym. 2011, 86: 555-565. 35. Leong KH, Chung LY, Noordin MI, Mohamad K, Nishikawa M, Onuki Y, Morishita M, Takayama K. Carboxymethylation of kappa-carrageenan for intestinal-targeted delivery of bioactive macromolecules. Carb Polym. 2011, 83: 15071515. 36. Gan, C.S., CW Wang, & Tan KS. (2012). Circulatory microRNA-145 expression is increased in cerebral ischemia, Genet. Mol. Biol. 11 (1): 147-152. (ISI/SCOPUS Cited Publication). [Impact factor – 0.634, ISI JCR@ Ranking 2011,132/290, TIER II (Biochemistry & Molecular Biology)] [Citation: ISI – 2] 37. Raja Izaham RM, Abdul Kadir MR, Abdul Rashid AH, Hossain MG, Kamarul T. Finite element analysis of Puddu and Tomofix plate fixation for open wedge high tibial osteotomy. Injury (2012) Jun;43(6):898-902. doi: 10.1016/j. injury.2011.12.006 38. Mokhtar AS, Lim SF, Tay ST. First Molecular Detection of Anaplasma platys and Babesia gibsoni in Dogs in Malaysia. Accepted by Tropical Biomedicine, 2012. Thesis Master of Medical Science Degree (Aida Syafinaz Mokhtar) 39. Chan Y.F., Wee, K.L., Chiam, C.W., Khor, C.S., Chan, S.Y., Wan Nor Amalina W.M.Z., Sam, I.C. (2012). Comparative Genetic Analysis of VP4, VP1 and 3D Gene Regions of Enterovirus 71 and Coxsackievirus A16 Circulating in Malaysia between 1997-2008. Tropical Biomedicine 29: 451-466. 40. Ng KP, Ngeow YF, Yew SM, Hassan H, Soo-Hoo TS, Na SL, Chan CL, Hoh CC, Lee KW, Yee 35 36 High Impact Research Annual Report 2012 WY. 2012. Draft Genome Sequence of Daldinia eschscholzii Isolated from Blood Culture. Eukaryotic Cell 11(5):703-704. DOI: 10.1128/ EC.00074-12. 41. Ng KP, Yew SM, Chan CL, Soo-Hoo TS, Na SL, Hassan H, Ngeow YF, Hoh CC, Lee KW, Yee WY. 2012. Genome sequence of an unclassified pleosporales species isolated from human nasopharyngeal aspirate. Eukaryotic Cell 11(6):828. doi: 10.1128/EC.00133-12. 42. Lai S-L, Cheah S-C, Wong P-F, Noor SM, Mustafa MR (2012) In Vitro and In Vivo AntiAngiogenic Activities of Panduratin A. PLoS ONE 7(5): e38103. 43. Aditya Arya, Shiau Chuen Cheah, Chung Yeng Looi, Hairin Taha, Mohd. Rais Mustafa and Mustafa Ali Mohd. The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats. Food and Chemical Toxicology . 2012 Nov;50(11):4209-20 44. Ismail Adam Arbab, Chung Yeng Looi, Ahmad Bustamam Abdul, Foo Kit Cheah, Won Fen Wong, Mohd Aspollah Sukari, Rasedee Abdullah, Syam Mohan, Suvitha Syam, Aditya Arya, Manal Mohamed Elhassan Taha, Bushra Muharram, Mohd Rais Mustafa and Siddig Ibrahim Abdelwahab. 2012. Dentatin induces apoptosis in prostate cancer cells via Bcl-2, Bcl-xL, Survivin downregulation, caspase-9, -3/7 activation and NF-kB inhibition. EvidenceBased Complementary and Alternative Medicine. 2012;2012:856029 45. Aditya Arya, Chung Yeng Looi, Shiau Chuen Cheah, Mohd Rais Mustafa and Mustafa Ali Mohd. Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, β-TC6 and its alleviating role in type 2 diabetic rats. Journal of Ethnopharmacology. 2012 Oct 31;144(1):22-32 46. Arya A, Achoui M, Cheah SC, Abdelwahab SI, Narrima P, Mohan S, Mustafa MR, Mohd MA. Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. Evid Based Complement Alternat Med. 2012;2012:627256. doi: 10.1155/2012/627256. 47. Lay-Hoong Lian, Ai-Chin Loke, Nor Z Zainal, Zahurin Mohamed. Association study of the tryptophan hydroxylase 1 gene with major depressive disorder in three ethnic groups of the Malaysian population. Asian Biomedicine (2012) (Accepted for pubication) (ISI-Cited Publication) 48. Shamsul Mohd Zain, Rosmawati Mohamed, Sanjiv Mahadeva,Cheah Phaik Leng,Sanjay Rampal,Roma Choudhury Basu, Zahurin Mohamed. (2012) A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease. Human Genetics 2012; 131(7): 114552 (Tier 1, Impact Factor 5.047). (ISI-Cited Publication) 49. Yamunah Devi Apalasamy, Moy Foong Ming, Sanjay Rampal, Awang Bulgiba, Zahurin Mohamed. 2012. Genetic association study between SNPs in FTO gene and predisposition to obesity in Malaysian Malays. Brazilian Journal of Medical and Biological Research 2012 (ISI-Cited Publication) 50. Batoul Sadat Haerian, Larry Baum, Hui Jan Tan, Patrick Kwan, Azman Ali Raymond, Junji Saruwatari, Kazuko Nakagawa, Zahurin Mohamed. 2012. SCN1A IVS5N+5 polymorphism and response to sodium valproate: A multicenter study. Pharmacogenomics 2012 (Tier 1). 13(13):1477-85. doi: 10.2217/pgs.12.127. Accepted for publication (ISI-Cited Publication) 51. Yamunah Devi Apalasamy, Moy Foong Ming, Sanjay Rampal, Awang Bulgiba and Zahurin Mohamed. 2012. Association of Melanocortin-4 Receptor Gene Polymorphisms with Obesityrelated Parameters in Malaysian Malays. Annals of Human Biology 2012 (accepted) (ISI-Cited Publication) 52. Y.D. Apalasamy, M.F. Ming, S. Rampal, A. Bulgiba and Z. Mohamed. 2012. Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays. Braz J Med Biol Res-provisional Epub Aug 23, 2012, http://dx.doi.org/10.1590/S0100879X2012007500134 (ISI-Cited Publication) 53. Ghasemi R, Haeri A, Dargahi L, Mohamed Z, Ahmadiani A. 2012. Insulin in the brain: Sources, Localization and Functions. Mol Neurobiol [Epub ahead of print] Tier 1 (ISI-Cited Publication) 54. Mohd Aizat Zain, Suffee Nusrat Jahan, Gavin P Reynolds, Nor Zuraida Zainal, Sharmilla Kanagasundram and Zahurin Mohamed 2012. Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration.BMC Medical Genetics 2012. doi: 10.1186/1471-235013-91 Journal: BMC Medical Genetics (ISI-Cited Publication) 55. Vijayapandi Pandy, Megala Narasingam and Zahurin Mohamed. Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice. BMC Complementary and Alternative Medicine 2012. doi: 10.1186/1472-6882-12-186 (ISI-Cited Publication) Tier 1 56. Shamsul Mohd Zain, Zahurin Mohamed, Sanjiv Mahadeva, Phaik-Leng Cheah, Sanjay Rampal,II Kin-Fah Chin, Roma Choudhury Basu, Hwa-Li Tan, and Rosmawati Mohamed. The impact of LEPR variants on risk of non-alcoholic fatty liver disease and its interaction with PNPLA3 variant. Journal of Gastroenterology and Hepatology 2012. (ISI-Cited Publication) 57. Apalasamy, Y.D., Ming, M.F., Rampal, S., Bulgiba, A., Mohamed, Z., 2012. Association of melanocortin-4 receptor gene polymorphisms with obesity-related parameters in Malaysian Malays. Annals of human biology.DOI:10.3109/03 014460.2012.720709 (ISI-Cited Publication). 58. Wong KT, Ng KY, Ong KC, Ng WF, Shankar SK, Mahadevan A, Radotra B, Su IJ, Lau G, Ling AE, Chan KP, Macorelles P, Vallet S, Cardosa MJ, Desai A, Ravi V, Nagata N, Shimizu H, Takasaki T. High Impact Research Annual Report 2012 Enterovirus 71 encephalomyelitis and Japanese encephalitis can be distinguished by topographic distribution of inflammation and specific intraneuronal detection of viral antigen and RNA. Neuropathology and Applied Neurobiology 2012; 38: 443-453 World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012. (2012). The International Journal of Neuropsychopharmacology, 15(SupplementS1), 1-271. doi:10.1017/S1461145712000508. (ISIcited publication). 59. Mathieu C, Guillaume V, Sabine A, Ong KC, Wong KT, Legras-Lachuer C, Horvat B. Lethal Nipah virus infection induces rapid overexpression of CXCL10 in endothelial cells. PLoS ONE 2012; 7 (2):e32157. doi:10.1371/ journal.pone.0032157 68. Fatemeh Molaei V, Maysam O, Fatimah I, Rusdi AR, Mohamad Hussain H, Kheng Seang L, Siew Cheok N. ( 2012). EEG analysis of the initial methadone treatment in heroin dependent. Medical and Biology Engineering and Computing. Under review. 60. Mathieu C, Guilaume V, Volchkova V, Pohl C, Jacquot F, Looi R, Wong KT, Legras Lachuer C, Volchkov V, Lachuer J, Horvat B. Nonstructural Nipah virus C protein regulates both the early host proinflammatory response and viral virulence. Journal of Virology 2012; 86: 1076610775 69. Fung, S.Y., Tan, N.H., Sim, S.M. and Aguiyi, J.C. 2012. Effect of Mucuna pruriens seed extract pretreatment on the responses of spontaneously beating rat atria and aortic ring to Naja spuatrix (Javan spitting cobra) venom. Evidence-based Complementary and Alternative Medicine. Vol 2012, ID 486390. Doi:10.1155/2012/486390. 61. Ch’ng WC, Stanbridge EJ, Wong KT, Ong KC, Yusoff K, Shafee N. Immunization with recombinant enterovirus 71 viral capsid protein 1 fragment stimulated antibody responses in hamsters. Virology Journal 2012; 9:155 70. Leong, P.K., Tan, N.H., Fung, S.Y. and Sim, S.M. (2012). Cross neutralization of Southeast Asian cobra and krait venoms by Indian polyvalent antivenoms. Trans Royal Soc Tropical Med. http://dx.doi.org/10.1016/j.trstmh.2012.07.009. (Tier-2). 62. Ploquin A, Szécsi J., Mathieu C, Guillaume V , Barateau V, Ong KC, Wong KT, Cosset FL, Horvat B, Salvetti A. Protection against henipavirus infection using recombinant AAV vector vaccines Journal of Infectious Diseases 2012 (in press). 63. Wong KT, Tan CT. Clinical and pathological manifestations of human henipavirus infection. Curr Top Microbiol Immunol 2012; 359: 95-104 64. Tan, KS, HG Lee, LH Lian, Lu YS, BC Chen, CW Wang, & Menon J. (2012). Mitochondrial neurogastrointestinal encephalomyopathy(MNGIE) in a Malaysian patient with a novel mutation in thymidine phosphorylase gene: A Case Report. Neurology Asia 17(2) : 163 – 168. (ISI/SCOPUS Cited Publication). [Impact Factor 0.186, ISI JCR@ Ranking 2011,134/192, TIER III (Clinical neurology)] 65. Kheng-Seang Lim, Cathie Wu, Wan-Yuen Choo, Chong-Tin Tan. Development and validation of a Public Attitudes Toward Epilepsy (PATE) scale. Epilepsy and Behavior 2012; 24(2):207-12 66. Siti Idayu H, Rusdi AR, Muhammad Muhsin AZ, Chong Guan N, Ahmad Hatim S, Fatimah I, Noor Zuraini R, Rahimah AK, Muna M, Mohamad Hussain H, Wan Azlinda Irnee WH. A study on the effectiveness of electroacupuncture as adjunctive treatment among methadone maintenance therapy clients in University of Malaysia Medical center, kuala Lumpur, Malaysia. Abstracts from the 28th CINP World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012. (2012). The International Journal of Neuropsychopharmacology, 15(SupplementS1), 1-271.doi:10.1017/ S1461145712000508. (ISI-cited publication). 67. Wan Azlinda Irnee WH, Siti Idayu H, Azhar S, Muna M,Rusdi AR, Mohamad Hussain H. Amphetamine-type stimulants use among drug users on the street at Chow Kit Road, Kuala Lumpur, Malaysia. Abstracts from the 28th CINP 71. R.Jayakumar, M.S. Kanthimathi. 2012. Dietary spices protect against hydrogen peroxideinduced DNA damage and inhibit nicotineinduced cancer cell migration. Food Chemistry. 134:1580-1584 72. R Ngui, YAL Lim, KH Chua (2012). Rapid detection and identification of human hookworm infections through high resolution melting (HRM) analysis. PloS One 7:e41996 73. SD Puthucheary, SM Puah, KH Chua (2012). Molecular Characterization of Clinical Isolates of Aeromonas Species from Malaysia. PLoS ONE 7(2):e30205 74. CH Chew, YAL Lim, PC Lee, R Mahmud and KH Chua (2012). A hexaplex PCR detection system for the identification of five human Plasmodium species with internal control. Journal of Clinical Microbiology. 12:4012-4019 75. Salem, S.D., Saif-Ali, R.,Ismail, I.S., Al-Hamodi, Z., Poh, R. and Muniandy, S. (2012). IGF2BP2 Alternative Variants Associated with Glutamic Acid Decarboxylase Antibodies Negative Diabetes in Malaysian Subjects. Plos One, 7(9): e45573. doi:10.1371/journal.pone.0045573 76. Razali N, Mat-Junit S, Abdul-Muthalib AF, Subramaniam S, Abdul-Aziz A. Effect of various solvents on the extration of antioxidant phenolics from the leaves, seeds, veins and skins of Tamarindus idica L. Food Chem. 2012 Mar;131(2):441-8. 77. Kong KW, Mat-Junit S, Aminudin N, Ismail A, Abdul-Aziz A. Antioxidant activities and polyphenolics from the shoots of Barrigtonia racemosa (L.) Spreng in a polar to apolar medium system. Food Chem. 2012 Sep;134(1):324-332. 78. Jayapalan JJ, Ng KL, Razack AH, Hashim OH. Identification of potential complementary serum biomarkers to differentiate prostate cancer from benign prostatic hyperplasia using 37 38 High Impact Research Annual Report 2012 gel- and lectin-based proteomics analyses. Electrophoresis. 2012 Jul;33(12):1855-62. 79. Chong URW, Abdul-Rahman PS, Abdul-Aziz A, Hashim OH, Mat-Junit S. Tamarindus indica extract alters of alpha enolase, apolipoprotein A-I, transthyretin and Rab GDP dissociation inhibitor beta from HepG2 cells. PLoS ONE. 2012 Jun;7(6) 80. Zaki, R., Bulgiba, A., Ismail, R., & Ismail, N. A. (2012). Statistical Methods Used to Test for Agreement of Medical Instruments Measuring Continuous Variables in Method Comparison Studies: A Systematic Review. PLoS ONE, 7: e37908.doi:10.1371/journal.pone.0037908 81. Moy FM, Ray A, Buckley B. 2012. Techniques of monitoring blood glucose during pregnancy for women with pre-existing diabetes (Protocol). Cochrane Review Database of Systematic Review, Issue 2. (ISI-Cited Publication) 82. Chu, A.H.Y., Moy, F.M., 2012. Associations of occupational, transportation, household and leisure-time physical activity patterns with metabolic risk factors among middle-aged adults in a middle-income country. Preventive Medicine.DOI:http://dx.doi.org/10.1016/j. ypmed.2012.12.011 (ISI-Cited Publication) 83. Noran N Hairi, Awang Bulgiba, Devi Peramalah, Izzuna Mudla. Do older people with visual impairment and living alone in a rural developing country report greater difficulty in managing stairs? Preventive Medicine (2012), http://dx.doi. org/10.1016/j.ypmed.2012.10.016 (ISI-Cited Publication) 84. Kamkaew A, Lim SH, Lee HB, Kiew LV, Chung LY, Burgess K. BODIPY dyes in photodynamic therapy. Chem Soc Rev. (2012) DOI: 10.1039/ c2cs35216h (Impact Factor 28.76) FACULTY OF ENGINEERING 1 2 3 4 Shahbaz K., Mjalli F. S., Hashim M. A., AlNashef I. M., Eutectic Solvents for The Removal of Residual Palm Oil-Based Biodiesel Catalyst, Journal of Separation and Purification Technology. 2011, 81, pp. 216-222 (Elsevier) (Q1) Shahbaz K., Mjalli F. S., Hashim M. A., AlNashef I. M., Eutectic Solvents for The Removal of Residual Palm Oil-Based Biodiesel Catalyst, Journal of Separation and Purification Technology. 2011, 81, pp. 216-222 (Elsevier) (Q1) Shahbaz K., Mjalli F. S., Hashim M. A., AlNashef I. M., Using Deep Eutectic Solvents Based on Methyl Triphenyl Phosphunium Bromide for the Removal of Glycerol from Palm Oil-Based Biodiesel, Energy & Fuel, 2011, 25, pp. 2671– 2678 (ACS) (Q1) Hayyan A., . Mjalli F.S, Hashim M.A., Hayyan M., AlNashef I.M., Al-Zahrani S.M., Al-Saadi M.A, Ethanesulfonic Acid-based Esterification of Industrial Acidic Crude Palm Oil for Biodiesel Production. Bioresource Technology 2011 Vol. 102, No. 20, pp. 9564-9570 (Elsevier) (Q1) 5 S.Nosrati, N.S. Jayakumar, M.A. Hashim, Performance evaluation of supported ionic liquid membrane for removal of phenol, Journalof Hazardous Materials, 2011, 192 ,1283–1290 6 Rahul Kumar Goyal, N.S.Jayakumar, M.A.Hashim, Emulsion stabilization using ionic liquid [BMIM] + [NTf2] and performance evaluation on the extraction of chromium, Journal of Hazardous Materials, 2011, 195, 55– 61 7 Rahul Kumar Goyal, N.S.Jayakumar, M.A.Hashim, A comparative study of experimental optimization and response surface optimization of Cr removal by emulsion ionic liquid membrane, Journal of Hazardous Materials, 2011, 195, 383– 390 8 Rahul Kumar Goyal, N.S.Jayakumar, M.A.Hashim, Chromium removal by emulsion liquid membrane using [BMIM] as stabilizer and TOMAC as extractant + [NTf2] , 2011, Desalination 278, 50–56 9 Maqsood Ahmad Malik, Mohd Ali Hashim, Firdosa Nabi, Ionic liquids in supported liquid membrane technology, 2011, Chemical Engineering Journal 171, 242–254 10 S.M. Shafie, T.M.I. Mahlia, H.H. Masjuki, A. 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Mekhilef, A. Safari, H.A. Mohammed. An overview of different distillation methods for small scale applications. Renewable and Sustainable Energy Reviews. 15 (2011) 4756-64. 24 Nazir R, Mazhar M, Wakeel T, Akhtar MJ, Siddique M, Nadeem M, Khan NA, Shah R. Pyrolysis Mechanism of Trisbipyridineiron(II) Chloride to Iron Nanoparticles. J. Therm Anal Calorim (2011) DOI:10.1007/s10973-011-1919-5 25 R. Saidur, M. Hasanuzzaman, T.M.I. Mahlia, N.A. Rahim, H.A. Mohammed. Chillers energy consumption, energy savings and emission analysis in an institutional buildings. Energy. 36 (2011) 5233-8. 26 A. Mahmoudi, N. A. Rahim, W. P. Hew “An Analytical Complementary FEA Tool for Optimizing of Axial-Flux Permanent-Magnet Machines” International Journal of Applied Electromagnetics and Machines (IJEAM), Vol. 37, No. 1, 19-34, September 2011. (ISI/SCOPUS Cited Publication) 27 A. Mahmoudi, N. A. Rahim, W. P. 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Impact of coconut oil blends on particulatephase PAHs and regulated emissions from a light duty diesel engine. Energy. 2012;48(1):5009. DOI: http://dx.doi.org/10.1016/j. energy.2012.10.009 54 Maan Hayyan, Mohd Ali Hashim, Adeeb Hayyan, Mohammed A. Al-Saadi, Inas M. AlNashef, Mohamed E.S. Mirghani, Olorunnisola Kola Saheed. Are Deep Eutectic Solvents Benign or Toxic? Chemosphere, Doi: 10.1016/j. chemosphere.2012.11.004, 2012.( Elsevier) 55 Adeeb Hayyan, Mohd Ali Hashim, Farouq S. Mjalli, Maan Hayyan, Inas M. AlNashef. A Novel Phosphonium-Based Deep Eutectic Catalyst for Biodiesel Production from Low grade Crude Palm Oil. Chemical engineering science, 10.1016/j.ces.2012.12.024 (Elsevier) Q1 56 Andriyana A, Chai AB, Verron E, Johan MR. Interaction between diffusion of palm biodiesel and large strain in rubber: Effect on stress-softening during cyclic loading. Mechanics Research Communications. 43, 80-86. 2012. 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Neural network predictive control of a SOFC fuelled with ammonia. Int. J. Electrochem. Sci. 7 (2012) 3737-3749. 106 Saleem M, Essa MH, Chakrabarti MH, Low CTJ, Hajimolana SA, Hussain MA, Hashim MA, Islam MS. An economical means for remediating a multiple-metal contaminated soil using electrokinetic technology under natural conditions. Int. J. Electrochem. Sci. 7 (2012) 7809-7822. High Impact Research Annual Report 2012 107 Low CTJ, Walsh FC, Chakrabarti MH, Hashim MA, Hussain MA. Electrochemical approaches to the production of graphene flakes and their potential applications. Carbon (2012) In Press. http://dx.doi.org/10.1016/j.carbon.2012.11.030 108 Yasmin Abdul Wahab, Anuar Fadzil Ahmad, Hanim Hussin and Norhayati Soin. 2012. Reduction of Annealed-Induced Wafer Defects in Dual-Damascene Copper Interconnects. Microelectronics Reliability, Volume 52, Issues 9 10, September October 2012, Pages 1975-1980. (ISI-Cited Publication) 109 I. Izuddin, M.H. Kamaruddin , A.N. Nordin ,N. Soin. Trench DMOS interface trap characterization by three-terminal charge pumping measurement, Microelectronics Reliability, Volume 52, Issue 12, December 2012, Pages 2914-2919 (ISI-Cited Publication) 110 Sadia Manzoor, , Nissar Mohammad Karim, Norhayati Soin. Unification of Contemporary Negative Bias Temperature Instability Models for p-MOSFET Energy Degradation. Renewable & Sustainable Energy Reviews. 2012. , ISI (Thomson Reuters) and SCOPUS indexed trench-gate DMOS Fowler-Nordheim tunnelling stress. Microelectronic Engineering. 2012. 119 K.Y. Leong, R. Saidur, T.M.I. Mahlia, Y.H. Yau. Performance investigation of nanofluids as working fluid in a thermosyphon air preheater. International Communications in Heat and Mass Transfer. 39 (2012) 523-9. 120 T.M.I. Mahlia, H.M. Ng, T. Olofsson, A. Andriyana, I. Hasanuddin. Energy and cost savings of optimal thickness for selected insulation materials and air gaps for building walls in tropical climate. Energy Education Science and Technology Part A: Energy Science and Research. 29 (2012) 649-62. 121 K.Shahbaz,; F.S. Mjalli, M.A. Hashim, I.M. AlNashef Prediction of the Surface Tension of Deep Eutectic Solvents. Fluid Phase Equilibria Journal, 2012, 319, pp. 48-54 (Elsevier, Q1) 122 Y. Farazila, Y. Miyashita , Y. Mutoh , M. Hamdi. Effect of anodizing on pulsed Nd:YAG laser joining of polyethylene terephthalate (PET) and aluminium alloy (A5052). Materials and Design 37 (2012) 410–415 111 N.M. Karim, S. Manzoor, N. Soin, S.F. Yew, M. Mounir. Prediction of energy change due to hot carrier injection. Microelectronic Engineering. 2012. ISI (Thomson Reuters) and SCOPUS indexed 123 Y. Farazila, Y. Miyashita, Y. Mutoh, M. Raza. Utilising friction spot joining for dissimilar joint between aluminium alloy (A5052) and polyethylene terephthalate. Science and Technology of Welding and Joining 2012;17(7):544-549 112 N.M. Karim, S. Manzoor, N. Soin. Statistical forecasting algorithm on circuit level gain transformation due to negative bias temperature instability under microwave frequency spectrum. Journal of Computational Electronics. 2012 , ISI (Thomson Reuters) and SCOPUS indexed 124 E. Zulkarnain, M. Hamdi, W. Basirun. Supercapacitance of bamboo-type anodic titania nanotube arrays. Surface & Coatings Technology (2012) http://dx.doi.org/10.1016/j. surfcoat.2012.07.098 113 H. Hussin, Y. Abdul Wahab, S. Shahabuddin, and N. Soin, “Behaviour of the Recoverable Dynamic NBTI Component on p-MOSFETs”. Microelectronic Engineering. 2012. ISI (Thomson Reuters) and SCOPUS indexed 114 Y.Abdul Wahab, A.F. Ahmad, H. Hussin, S. Shahabuddin, N. Soin. 2012. Integrated Diffuser Process Optimizations on Defect Metrology Performance. 38th International Micro & Nano Engineering Conference (MNE 2012). Microelectronic Engineering, MEE-0-12-00589submitted. 115 Shafigh, P., Mahmud, B., Jumaat, MZ. Oil palm shell lightweight concrete as a ductile material. Material & design.2012 April;36:650-654 116 M. A. Kareem, F. S. Mjalli, M. A. Hashim, I. M. Al-Nashef Liquid-liquid equilibria for the ternary system (phosphonium-based deep eutectic solvents-benzene-hexane) at different temperature: a new solvent introduced. Fluid Phase Equilibria Journal. 2012, 314, Pages 52–59; (Elsevier) (Q1) 117 K.Y. Leong, R. Saidur, T.M.I. Mahlia, Y.H. Yau. Modeling of shell and tube heat recovery exchanger operated with nanofluid based coolants. International Journal of Heat and Mass Transfer. 55 (2012) 808-16. 118 M.H. Kamaruddin, N. Soin. Application of Three-terminal Charge Pumping Measurement in 125 E. Zulkarnain, M. Hamdi, W. Basirun. Pseudocapacitive performance of vertical copper oxide nanoflakes. Thin Solid Films (2012)http:// dx.doi.org/10.1016/j.tsf.2012.09.084 126 H. Nur, G. Lee Kee, H. Hamdan, T.M. Indra Mahlia, J. Efendi, H.S. Cornelis Metselaar. Organosulfonic acid functionalized zeolite ZSM5 as temperature tolerant proton conducting material. International Journal of Hydrogen Energy. 37 (2012) 12513-21. 127 B. Rismanchi, R. Saidur, H.H. Masjuki, T.M.I. Mahlia. Thermodynamic evaluation of utilizing different ice thermal energy storage systems for cooling application in office buildings in Malaysia. Energy and Buildings. 53 (2012) 117-26. 128 M. Shekarchian, M. Moghavvemi, B. Rismanchi, T.M.I. Mahlia, T. Olofsson. The cost benefit analysis and potential emission reduction evaluation of applying wall insulation for buildings in Malaysia. Renewable and Sustainable Energy Reviews. 16 (2012) 4708-18. 129 Chong WT, Fazlizan A, Poh SC, Pan KC, Ping HW. Early development of an innovative building integrated wind, solar and rain water harvester for urban high rise application. Energy and Buildings. 2012;47:201-7. 130 Chong WT, Poh SC, Fazlizan A, Pan KC. Vertical axis wind turbine with omni-directional-guidevane for urban high-rise buildings. Journal 43 44 High Impact Research Annual Report 2012 of Central South University of Technology. 2012;19:727-32. 131 A. Mahmoudi, S. Kahourzade, N. A. Rahim, H. W. Ping, and N. F. Ershad “Slot-less TORUS SolidRotor-Ringed Line-Start Axial-Flux PermanentMagnet Motor” Progress In Electromagnetics Research (PIER), Vol. 131, 331-355, 2012. (ISI/ SCOPUS Cited Publication). 132 A. Mahmoudi, S. Kahourzade, N. A. Rahim, and H. W. Ping “Improvement to Performance of Solid-Rotor-Ringed Line-Start Axial-Flux Permanent-Magnet Motor” Progress In Electromagnetics Research (PIER), Vol. 124, 383404, 2012. (ISI/SCOPUS Cited Publication). 133 A. Mahmoudi, N. A. Rahim, W. P. Hew “Axial-Flux Permanent-Magnet Motor Design for Electric Vehicle Direct Drive using Sizing Equation and Finite Element Analysis” Progress In Electromagnetics Research (PIER), Vol. 122, 467496, 2012. (ISI/SCOPUS Cited Publication). 134 A. Saghafinia, S. Kahourzade, A. Mahmoudi, W. P. Hew, M. Nasir Uddin, “Broken Rotor Bar Fault Detection of 3-Phase Induction Motor using Online Adaptive Continuous Wavelet Transform and Fuzzy Logic” International Review of Electrical Engineering (IREE), Vol. 7, No. 3, 4383-4394, May-June 2012. (ISI/SCOPUS Cited Publication) Growth-Inhibitory Effect in Various Cancer Cell lines and Apoptosis in Ca Ski Human Cervical Epidermoid Carcinoma Cells. EvidenceBased Complementary and Alternative Medicine. Vol. 2011, (2011), 13 pages, doi:10.1155/2011/293060 4 Amid M., Tan C. P., Mirhosseini H., Norashikin Ab. Aziz, Ling, T.C. Optimisation of freeze drying conditions for purified serine protease from mango (Mangifera Indica Cv. Chokanan) peel, Food Chemistry, 128, (2011) 158-164. 5 Show, P.L., Tan, C.P., Anuar, M.S., Ariff, A., Yusof, Y.A., Chen, S.K., Ling, T.C. Direct recovery of lipase derived from Burkholderia Cepacia with aqueous two-phase flotation, Separation and Purification Technology, 80, (2011) 577 - 584. 6 Nor Adila Mhd Omar, Noorlidah Abdullah, Umah Rani Kuppusamy, Mahmood Ameen Abdulla and Vikineswary Sabaratnam (2011). Nutritional composition, antioxidant capacity and antiulcer potential of Lentinus squarrosulus (Mont.) mycelia extract. Evidenced-Based Complementary and Alternative Medicine. volume 2011,doi:10.1155/2011/539356 (ISI-Cited Publication) 7 Mahmood Ameen Abdulla, Atieh Abdollahi Fard, Vikineswary Sabaratnam, Kah-Hui Wong, Umah Rani Kuppusamy, Noorlidah Abdullah and Salmah Ismail (2011). Potential activity of aqueous extract of culinary-medicinal Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats. International Journal of Medicinal Mushrooms (IJMM)13(1): 33-39 8 Kah-Hui Wong, Murali Naidu, Pamela David, Mahmood Ameen Abdulla, Noorlidah Abdullah, Umah Rani Kuppusamy, and Vikineswary Sabaratnam. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoro mycetideae). Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 580752, 2011, 10 pages doi:10.1093/ecam/ neq062 9 Zukerman-Schpector, J., Otero-de-la-Roza, A., Luan . & Tiekink, E.R.T. 2011. Supramolecular architectures based on As(lone pair).pi(aryl) interactions. Chemical Communications 47:76087610. 135 Khalaf Salloum Gaeid, Hew Wooi Ping, Mustafa Khalid, Ammar Masaoud, 2012. Sensor and sensorless fault tolerant control for induction motors using a wavelet index. Sensors 2012, 12, 4031-4050. (ISI-Cited Publication) 136 A. Mahmoudi, S. Kahourzade, N. A. Rahim, and H. W. Ping “Optimum Design of an InsideOut Axial-Flux Permanent-Magnet Motor using Genetic Algorithm and Finite Element Analysis” International Review of Electrical Engineering (IREE), Vol. 7, No. 2, 3814-3827, 2012. (ISI/ SCOPUS Cited Publication) 137 E.Sadeghinezhad, S.N.Kazi, M.Dahari, Mohammad Reza Safaei, Rad Sadri, A. Badarudin, A comprehensive review of milk fouling on heated surfaces, J. Critical Reviews in Food Science and Nutrition, Accepted in Nov 2012 FACULTY OF SCIENCE 1 2 3 ZX Ng, UR Kuppusamy, I Tajunisah, Kenneth CSF, Adrian CAK, KH Chua. 2011. 2245G/A polymorphism of the receptor for advanced glycation end-products (RAGE) gene is associated with diabetic retinopathy in the Malaysian population. British Journal of Ophthalmology 96(2): 289-292 Amid M., Tan C. P., Mirhosseini H., Norashikin Ab. Aziz, Ling, T.C. Optimisation of serine protease extraction from mango peel (Mangifera Indica Cv. Chokanan), Food Chemistry, 124, (2011) 666 671. Yan Hsiung Wong & Habsah Abdul Kadir. Leea indica Ethyl Acetate Fraction Induces 10 Tiekink, E.R.T. & Zukerman-Schpector, J. 2011. Emerging supramolecular synthons: C-H. pi(chelate) interactions in metal bis(1,1-dithiolates). Chemical Communications 47:6623-6625. 11 I. Ling, Y. Alias, A. N. Sobolev, B. W. Skelton and C. L. Raston. Site specific Co(III) sarcophagine binding in multi-component phosphonium and p-sulfonatocalix[4]arene systems. Dalton Transactions (2011), 40, 10337-10344. 12 M.R. Mahmoudian, W.J. Basirun and Y. Alias and A. Khorsand Zak. Electrochemical characteristics of coated steel with poly(N-methyl pyrrole) synthesized in presence of ZnO nanoparticles. Thin Solid Films (2011), 520, 258–265 High Impact Research Annual Report 2012 13 S. J. Tan, W. T. Robinson, K. Komiyama, T. S. Kam, Macrodasine A-G, macroline indole alkaloids incorporating fused spirocyclic tetrahydrofuran-tetrahydrofuran and tetrahydrofuran-tetrahydropyran rings, Tetrahedron, 2011, 67, 3830-3838. 24 Eik, L. F., Naidu M., David, P. Wong, K. H., Tan, Y. S. & Sabaratnam V., (2012). Lignosus rhinoceros (Cooke) Ryvarden: A Medicinal Mushroom that stimulates neurite outgrowth in PC-12 Cells. Journal of Evidence-Based Complementary and Alternative Medicine. 14 W. F. Ku, S. J. Tan, Y. Y. Low, K. Komiyama, T. S. Kam, Angustilobine and andranginine type indole alkaloids and an uleine-secovallesamine bisindole alkaloid from Alstonia angustiloba, Phytochemistry, 2011, 72, 2212-2218. 25 Reddy NS, Navanesan S, Sinniah SK, Wahab NA and Sim KS. 2012. Phenolic content, antioxidant effect and cytotoxic activity of Leea indica leaves. BMC Complementary and Alternative Medicine 12: 128 15 S. H. Lim, S. J. Tan, Y. Y. Low, T. S. Kam, Lumutinines A-D, Linearly Fused MacrolineMacroline and Macroline-Sarpagine Bisindoles from Alstonia macrophylla, J. Nat. Prod., 2011, 74, 2556-2562. 26 Phan Chia Wei, Wong Wei Lun,, Pamela David, Murali Naidu and Vikineswary Sabaratnam (2012). Pleurotus giganteus (Berk) Karunarathna & K.D. Hyde: Nutritional value and in vitro neurite outgrowth activity rat pheochromocytoma cells. BMC Complementary and Alternative Medicine. 12:102 16 Nazir R, Mazhar M, Wakeel T, Akhtar MJ, Siddique M, Nadeem M, Khan NA, Shah R. Pyrolysis Mechanism of Trisbipyridineiron(II) Chloride to Iron Nanoparticles. J. Therm Anal Calorim (2011) DOI:10.1007/s10973-011-1919-5 17 Yusof, N. S.; Khan, M. N. Kinetic and rheological measurements of the effects of inert 2-, 3- and 4-bromobenzoate ions on the cationic micellarmediated rate of piperidinolysis of ionized phenyl salicylate J. Colloid Interface Sci. 2011, 357, 121-128 18 Sim, Y. L.; Yusof, N. S.; Ariffin, A.; Khan, M. N. Effects of nonionic micelles on the rate of alkaline hydrolysis of N-(2’-methoxyphenyl) phthalimide (1):Kinetic and rheometric evidence for a transition from spherical to rodlike micelles uder the typical reaction conditions. J. 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Evidence-Based Complementary and Alternative Medicine. Vol. 2012, (2012), 11 pages, doi:10.1155/2012/684740 23 Lau, C. C., Noorlidah, A., Shuib, A. S. and Aminudin, N. 2012. Proteomic Analysis of Antihypertensive Proteins in Edible Mushrooms. J. Agric. Food Chem., 60 : 12341-12348. 27 Kanagasabapathy G, Kuppusamy UR, Abd Malek SN, Abdulla MA, Chua K, Sabaratnam V. 2012. Glucan-rich polysaccharides from Pleurotus sajor-caju (Fr.) Singer prevents glucose intolerance, insulin resistance and inflammation in C57BL/6J mice fed a high-fat diet BMC Complementary and Alternative Medicine. 12:261 28 Feroz, Shevin, Mohamad, Saharuddin, Bujang, Noraini, Abd Malek, Sri Nurestri, Tayyab, Saad. (2012). Multi-spectroscope and Molecular Modeling Approach to Investigate the Interaction of Flavokawain B with Human Serum Albumin. Accepted in Journal of Agricultural and Food Chemistry. 29 M. S. Zaroog and S. Tayyab (2012) Formation of molten-globule-like state during acid denaturation of Aspergillus niger glucoamylase. Process Biochemistry 47 (5): 775-784. 30 Ding, C.X., Li, X., Ding, Y.B., Li, X., Ng, S.W. & Xie, Y.S. 2012 A novel bis(4,4-bipyridylamine) ligand with a flexible butadiyne linker: syntheses, structures, and photoluminescence of d10 metal coordination polymers. Cryst. Growth Des. 12: 3465-3473. 31 Yan Hsiung Wong, Habsah Abdul Kadir & Sui Kong Liong. Bioassay-guided Isolation of Cytotoxic Cycloartane Triterpenoid Glycosides from the Traditionally Used Medicinal Plant Leea indica. Evidence-Based Complementary and Alternative Medicine. Vol. 2012, (2012), 11 pages, doi:10.1155/2012/164689 32 Gomathi Chan, Muhamad Noor Alfarizal Kamarudin, Daniel Zin Hua Wong, Nor Hadiani Ismail, Faizuri Abd. Latif, Aurengzeb Hasan, Khalijah Awang & Habsah Abdul Kadir. 2012. Mitigation of H2O2-induced mitochondrialmediated apoptosis in NG108-15 cells by novel mesuagenin C from Mesua kunstleri (King) Kosterm.Evidence-Based Complementary and Alternative Medicine. Volume 2012 (2012), Article ID 156521, 18 pages doi:10.1155/2012/156521 33 Selvakumar, P., Ling, T.C., Walker, S., Lyddiatt, A. (2012),Recovery of glyceraldehyde 3-phosphate dehydrogenase from an unclarified disrupted yeast using aqueous two-phase systems facilitated by distribution analysis of radio 45 46 High Impact Research Annual Report 2012 labelled analytes, Separation and Purification Technology, 85,28 - 34. 34 Mehdi Ebadi, Wan Jeffrey Basirun, Yatimah Alias, Mohammad Reza Mahmoudian, and Sim Yoke Leng. Investigation of electrodeposition of Ni Co Fe Zn alloys in DMSO with MHD effect. Materials Characterization (2012), 66, 46-55. 45 Ng, H. S., Tan, C. P., Mokhtar, M. N., Ibrahim, S., Ariff, A., Ooi, C. W., Ling, T. C. 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Dalton Transactions (2012), 41, 4884-4889 47 C.H Pua, H.ahmad, S.W Harun, RM De La Rue, “Study of Dual Wavelength Mode Competition in an Erbium Doped Fiber Laser (EDFL) Produced by Aciustic Waves, IEEE Journal of Quantum Electronics, vol 48, no12, pp 1499-1504, 2012 37 M.R. Mahmoudian, W.J. Basirun and Y. Alias. The electrical properties of a sandwich of electrodeposited polypyrrole nanofibers between two layersof reduced graphene oxide nanosheets. Electrochimica Acta (2012), 72, 53-60 48 S. J. Tan, G. Subramaniam, N. F. Thomas, T. S. Kam, Unusual nitrogenous derivatives from Alstonia, Natural Product Communications, 2012, 7, 739-742. 38 M.R. Mahmoudian, W.J. Basirun and Y. Alias. Preparation of ultra-thin polypyrrole nanosheets decorated with Ag nanoparticles and their application in hydrogen peroxide detection. Electrochimica Acta (2012), 72, 46-52. 39 I. Ling, Y. Alias, A. N. Sobolev, B. W. Skelton and C. L. Raston. 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CrystEngComm (2012), 14, 8541-8546 53 Boon Tong Goh, Siew Kien Ngoi, Seong Ling Yap, Chiow San Wong, Saadah Abdul Rahman. Effect of energetic ion beam irradiation on structural and optical properties of a-Si:H thin films. Thin Solid Films (2012). DOI:10.1016/j. tsf.2012.07.072 43 Show, P. L., Tan, C. P., Anuar, M. S., Ariff, A., Yusof, Y. A., Chen, S. K., Ling, T. C. (2012), Primary recovery of lipase and recycling phase components in aqueous two-phase system, Biochemical Engineering Journal, 60, 74 - 80. 54 Boon Tong Goh, Siew Kien Ngoi, Seong Ling Yap, Chiow San Wong, Chang Fu Dee, Saadah Abdul Rahman. Structural and optical properties of the nc-Si:H thin films irradiated by high energetic ion beams. Journal of Non-Crystalline Solids (2012). 44 Noorlidah Abdullah, Siti Marjiana Ismail, Norhaniza Aminudin, Adawiyah Suriza Shuib and Lau Beng Fye (2012). Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evidenced-Based Complementary and Alternative Medicine. doi:10.1155/2012/464238. 13 pages (ISI/ SCOPUS Cited Publication) 55 Su Kong Chong, Boon Tong Goh, Chang Fu Dee, Saadah Abdul Rahman. Effect of substrate to filament distance on formation and photoluminescence properties of indium catalyzed silicon nanowires using hot-wire chemical vapor deposition. Thin Solid Films (2012). DOI:10.1016/j.tsf.2012.07.098 High Impact Research Annual Report 2012 56 Su Kong Chong, Boon Tong Goh, Chang Fu Dee, Saadah Abdul Rahman. Study on the role of filament temperature on growth of indiumcatalyzed silicon nanowires by the hot-wire chemical vapor deposition technique. Materials Chemistry and Physics (2012). DOI:10.1016/j. matchemphys.2012.05.037 57 Su Kong Chong, Boon Tong Goh, Yuen-Yee Wong, Hong-Quan Nguyen, Hien Do, Ishaq Ahmad, Zarina Aspanut, Muhamad Rasat Muhamad, Chang Fu Dee, Saadah Abdul Rahman. 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J R Soc Interface. 2012 Dec 7;9(77):3528-38. doi: 10.1098/rsif.2012.0507. Epub 2012 Aug 22. 4 Malhotra R, Patel V, Chikkaveeraiah BV, Munge BS, Cheong SC, Zain RB, Abraham MT, Dey DK, Gutkind JS, Rusling JF. Ultrasensitive Detection of Cancer Biomarkers in the Clinic using a Nanostructured Microfluidic Array. Anal Chem 2012. 5 Ramanthan A., Yang YH, Mustafa WMW, Prepageran N. Survival of oral squamous cell carcinoma patients in Malaysia: Sociodemographic and clinicopathological correlation.6th Genral Assembly og the Asian Pacific Organization for Cancer Prevention, Clinical Epidemiology and Practical InterventionThe Future of Cancer Control in the Asian Pacific Region, 26-29 April 2012, Pullman Kuching, Sarawak, Malaysia. Abstract no FP3.8, pg 78. 6 Vincent-Chong VK, Anwar A, Karen-Ng LP, Cheong SC, Yang Y-H, Pradeep PJ, Rahman ZAA, Ismail SM, Zaini ZM, Prepageran N, Kallarakkal TG, Ramanathan A, Mohayadi NABM, Rosli NSBM, Mustafa WMW, Mannil TA, Tay KK, Zain RB. 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Under Review since 20/08/2012, ISI-Cited Publication, Tier-2) 2 Muhammad Shiraz , Abdullah Gani, Rashid Hafeez Khokar, Rajkumar Buyya A Review on Application Processing Frameworks in Mobile Devices for Mobile Cloud Computing IEEE Communications Surveys and Tutorials, IEEE (ACCEPTED, DOI: 10.1109/ SURV.2012.111412.00045, ISI Indexed Q1 (impact factor 6.3)). 3 Siti, S.S., Mumtaz, B.M., Noraini, M. The acceptance and use of Speech technology for pronunciation practice by children with dysarthria: an analysis based on TAM. Computers and Education, Under Review since 12/12/2012, ISI-Cited Publication, Tier 1) 4 Seyed Reza Shahamiri and Siti Salwa Binti Salim, Automatic Dysarthric Speech-Recognition based on Artificial Neural Networks: Identifying the Best Performing Set of MFCC Parameters and Proposing A Speaker-Independent Approach, IEEE Transactions on Neural Systems and FACULTY OF DENTISTRY 1 2 Noor Hayaty Abu Kasim, Vijayendran Govindasamy, Nareshwaran Gnanasegaran, Sabri Musa, Padmaja Jayaprasad Pradeep, Thekkeparambil chandrabose Srijaya and Zeti Adura Che Ab. Aziz. 2012. Unique molecular signatures influencing the biological function and fate of post-natal stem cells isolated from different sources. Journal of Tissue Engineering and Regenerative Medicine. DOI:10.1002/ term.1663 (Tier 1 paper) Thekkeparambil Chandrabose Srijaya, Padmaja Jayaprasad Pradeep, Rosnah Binti Zain, Sabri Musa, Noor Hayaty Abu Kasim Vijayendran Govindasamy. 2012. The promise of human induced pluripotent stem cells in dental research. Stem Cell International. 2012:1-10. Doi:10.1155/2012/423868. (Scopus cited) High Impact Research Annual Report 2012 Rehabilitation Engineering (2012) (under review) (ISI/SCOPUS Cited Publication) - Tier 1 5 Seyed Reza Shahamiri and Siti Salwa Binti Salim, Artificial Neural Networks as MultiNetworks Automated Speech Recognizers, Neurocomputing, (2012) (under review) (ISI/ SCOPUS Cited Publication) CHANCELLORY 1 Yee Meng Chong,Wai Fong Yin,Chia Yong Ho, Mohamad Rais Mustafa,A. Hamid A. Hadi,Khalijah Awang,Putri Narrima, Chong-Lek Koh, David R. Appleton,and Kok-Gan Chan. Malabaricone C from Myristica cinnamomea Exhibits Anti Quorum Sensing Activity. J. Nat. Prod., 2011, 74 (10), pp 2261–2264 2 Kok-Gan Chan, Steve Atkinson, Kalai Mathee, Choon-Kook Sam, Siri Ram Chhabra, Miguel C ra, Chong-Lek Koh, and Paul Williams. 2011. Characterization of N- Acylhomoserine Lactone-Degrading Bacteria Associated with the Zingiber officinale (ginger) rhizosphere: Coexistence of Quorum Quenching and Quorum Sensing in Acinetobacter and Burkholderia. BMC Microbiology 2011, 11:51 doi:10.1186/14712180-11-51 3 Yue-Jun Fu, Na An, Kok-Gan Chan, Yan-Bo Wu, Shu-Hua Zheng, Ai-Hua Liang. 2011. A model of BmK CT in inhibiting glioma cell migration via matrix metalloproteinase-2 from experimental and molecular dynamics simulation study. Biotechnology letters 2011;33(7):1309-17. 4 Krishnamurithy G, Shilpa PN, Ahmad RE, Sulaiman S, Ng CLL, Kamarul T. 2011. Human Amniotic Membrane as a Chondrocyte Carrier Vehicle/Substrate: In Vitro study. J Biomed Mater Res Part A 2011:99A:500–506 5 Haw, C. Y., Chia, C. H., Zakaria, S., Mohamed, F., Radiman, S., Teh, C. H., Khiew, P. S., Chiu, W. S. & Huang, N. M. 2011. Morphological studies of randomized dispersion magnetite nanoclusters coated with silica. Ceramics International 37: 451-464. (ISI-Cited Publication) 6 Sarmani, A. R.; Abu Bakar, M. H.; Bakar, A. A. A.; Adikan, F. R. Mahamd; Mahdi, M. A.; Spectral variations of the output spectrum in a random distributed feedback Raman fiber laser ; OPTICS EXPRESS, Vol. 19, Issue 15, pp. 14152 14159, July 18 2011 (ISI-Cited Publication) 7 Ismail, Mohd. Afiq; Tamchek, Nizam; Abu Hassan, Muhammad Rosdi; Dambul, Katrina D.; Selvaraj, Jeyraj; Abd Rahim, Nasrudin; Sandoghchi, Seyed Reza; Adikan, Faisal Rafiq Mahamd; A Fiber Bragg Grating-Bimetal Temperature Sensor for Solar Panel Inverters; SENSORS, Vol. 11, Issue 9, pp. 8665 8673, September 2011 (ISI-Cited Publication) 8 Hassan, M. R. A.; Tamchek, N.; Abas, A. F.; Johar, R. M.; Adikan, F. R. Mahamd, ‘Dual-phase sensing for early detection of prepreg structural failures via etched cladding Bragg grating’, SENSORS AND ACTUATORS A- PHYSICAL, Vol. 171, Issue 2, pp. 126-130, NOV 2011 (ISI-Cited Publication) 9 Siew Woh Choo and Steve Russell. Genomic approaches to understanding Hox gene function. Advances in Genetics 2011.76:55-91. 10 Xin Yue Chan, Kek Heng Chua, Savithri D. Puthucheary, Wai-Fong Yin and Kok-Gan Chan. Draft Genome Sequence of a Clinical Isolate Aeromonas sp. Strain 159 Which Shows Quorum Sensing Activity. J. Bacteriol. November 2012.194:6350; doi:10.1128/JB.01642-12 11 Teik Min Chong, Wai-Fong Yin, Samuel Mondy, Catherine Grandcl nt, Yves Dessaux, Kok-Gan Chan. Heavy Metal Resistance of a France Vineyard Soil Bacterium Pseudomonas mendocina Strain S5.2 Revealed by Whole Genome Sequence. J. Bacteriol. November 2012 194:6366; doi:10.1128/JB.01702-12 12 Chien-Yi Chang, Chong-Lek Koh, Choon-Kook Sam, Xin-Yue Chan, Wai Fong Yin, and Kok Gan Chan. Unusual Long- Chain N-Acyl Homoserine Lactone Production by and Presence of Quorum Quenching Activity in Bacterial Isolates from Diseased Tilapia Fish. PLoS ONE 7(8), Aug 29, 2012: e44034. doi:10.1371/journal.pone.0044034 13 Kar-Wai Hong, Han-Ming Gan, Siew-Moon Low, Patrick Kok Yuen Lee, Yee-Meng Chong, Wai-Fong Yin, Kok-Gan Chan. Draft Genome Sequence of Pantoea sp. Strain A4, a Rafflesia-Associated Bacterium That Produces N-Acylhomoserine Lactones as Quorum-Sensing Molecules J. Bacteriol. December 2012 vol. 194 no. 23 6610, doi: 10.1128/JB.01619-12 14 Cheng-Siang Wong, Wai-Fong Yin, Yeun-Mun Choo, Choon- Kook Sam, Chong-Lek Koh and Kok-Gan Chan. Coexistence of quorum quenching and quorum sensing in tropical marine Pseudomonas aeruginosa strain MW3A. World J of Microbiol & Biotechn Vol 28 (2), 2012: 453-461 15 Wai-Fong Yin, Kathiravan Purmal, Shenyang Chin, Xin- Yue Chan and Kok-Gan Chan. Long chain N-acyl homoserine lactone production by Enterobacter sp. isolated from human tongue surface. Sensors 2012, 12(11), 14307-14314; doi:10.3390/s121114307 16 Thiba Krishnan, Wai-Fong Yin and Kok-Gan Chan. Inhibition of Quorum Sensing-Controlled Virulence Factor Production in Pseudomonas aeruginosa PAO1 by Ayurveda Spice Clove (Syzygium Aromaticum) Bud Extract. Sensors 2012, 12(4), 4016-4030; doi:10.3390/s120404016 17 Wai-Fong Yin, Kathiravan Purmal, Shenyang Chin, Xin- Yue Chan and Kok-Gan Chan. Long chain N-acyl homoserine lactone production by Enterobacter sp. isolated from human tongue surface. Sensors 2012, 12(11), 14307-14314; doi:10.3390/s121114307 18 Kar-Wai Hong, Chong-Lek Koh, Choon-Kook Sam, Wai-Fong Yin and Kok-Gan Chan. Quorum Quenching Revisited From Signal Decays to Signalling Confusion. Sensors 2012, 12(4), 46614696; doi:10.3390/s120404661 49 50 High Impact Research Annual Report 2012 19 Teik-Min Chong, Chong-Lek Koh, Choon-Kook Sam, Yeun- Mun Choo, Wai-Fong Yin and Kok-Gan Chan. Characterization of Quorum Sensing and Quorum Quenching Soil Bacteria Isolated from Malaysian Tropical Montane Forest. Sensors 2012, 12(4), 4846- 4859; doi:10.3390/ s120404846 20 Li Ying Tan, Wai-Fong Yin and Kok-Gan Chan. Silencing Quorum Sensing through Extracts of Melicope lunu-ankenda. Sensors 2012, 12(4), 4339-4351; doi:10.3390/s120404339 21 Wai-Fong Yin, Kathiravan Purmal, Shenyang Chin, Xin-Yue Chan, Chong-Lek Koh, Choon-Kook Sam and Kok-Gan Chan. 2012. N-acyl homoserine lactone production by Klebsiella pneumoniae isolated from human tongue surface. 2012. Sensors. doi:10.3390/ s120x0000x 22 Patrick Kok Yuen Lee, Swee Yee Ng, Dennis Yong, Xue Ching Chai, Wai Fong Yin, and Kok Gan Chan. 2012. Molecular phylogeny characterisation of Malaysian fighting fish Betta pi (Teleostei: Osphronemidae) based on its 18S ribosomal DNA sequences Asia Life Sciences. 21(1): 57-64. 23 Cheng-Siang Wong, Wai-Fong Yin, ChoonKook Sam, Chong- Lek Koh, Kok-Gan Chan. Characterisation of Malaysian wetland quorum quenching Pseudomonas aeruginosa strain 2SW8 and its 2-heptyl-3-hydroxy-4-quinolone production. New Microbiologica, 35, 43-51, 2012. 24 Selva Perumal Gunaletchumy, Xinsheng Teh, Yalda Khosravi, Nur Siti Khadijah Ramli, Eng Guan Chua, Thevakumar Kavitha, Joanne N. Mason, Huey Tyng Lee, Halimah Alias, Nur Zafirah Zaidan, Norzawani Buang M. Yassin, Liang Chung Tay, Stephen Rudd, Hazel M.Mitchell, Nadeem O. Kaakoush, Mun Fai Loke, Khean Lee Goh, and Jamuna Vadivelu (2012) Draft genome sequences of Helicobacter pylori isolates from Malaysia, cultured from patients with functional dyspepsia and gastric cancer. J Bacteriol 194(20):5695. DOI: 10.1128/JB.01278-12. 25 Kumar N, Mukhopadhyay AK, Patra R, De R, Baddam R, Shaik S, Alam J, Tiruvayipati S, Ahmed N. Next-generation sequencing and de novo assembly, genome organization, and comparative genomic analyses of the genomes of two Helicobacter pylori isolates from duodenal ulcer patients in India. J Bacteriol. 2012 Nov;194(21):5963-4. 26 Ea CK, Hao S, Yeo KS, Baltimore D. 2012. EHMT1 Protein Binds to Nuclear Factor-kappaB p50 and Represses Gene Expression. J Biol Chem 287: 31207-31217. PMID:22801426 27 S. Vijay Kumar, N.M. Huang, H.N. Lim, A.R. Marlinda, I. Harrison, C.H. Chia. One-step size-controlled synthesis of functional graphene oxide/silver nanocomposite at room temperature. Chemical Engineering Journal (2012), doi: http:// dx.doi.org/10.1016/j. cej.2012.09.063 28 Kok Siong Yeo, Taznim Begam Mohd Mohidin, Ching Ching Ng. 2012. EBV-encoded LMP-1 upregulates 14-3-3σ and Reprimo to confer G2/M phase Cell Cycle Arrest. Comptes rendus Biologies 335 (2012), pp. 713-721 29 Jian-Woon Chen, Han Ming Gan, Wai-Fong Yin, Kok-Gan Chan.Genome Sequence of Roseomonas sp. Strain B5, a Quorum-quenching N-Acylhomoserine Lactones-Degrading Bacterium Isolated from Malaysian Tropical Soil. J. Bacteriol. December 2012 vol. 194 no. 23 6681-6682; doi: 10.1128/JB.01866-12 30 Nida Iqbal, Mohammed Rafiq Abdul Kadir, Nik Ahmad Nizam Nik Malek ,Nasrul Humaimi Mahmooda, Malliga Raman Murali, Tunku Kamarul. Rapid microwave assisted synthesis and characterization of nanosized silver-doped hydroxyapatite with antibacterial properties. Materials Letters 89 (2012) 118–122. 31 Chong, P.-P., Selvaratnam, L., Abbas, A. A. and Kamarul T. (2012), Human peripheral blood derived mesenchymal stem cells demonstrate similar characteristics and chondrogenic differentiation potential to bone marrow derived mesenchymal stem cells. J. Orthop. Res., 30: 634 642. doi: 10.1002/jor.21556 32 Tan SL, Ahmad RE, Ahmad TS, Merican AM, Abbas AA, Ng WM, Kamarul T. Effect of Growth Differentiation Factor 5 on the Proliferation and Tenogenic Differentiation Potential of Human Mesenchymal Stem Cells in vitro. Cells Tissues Organs. 2012 May 30. 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November 2012 vol. 194 no. 22 6331. doi: 10.1128/ JB.01637-12 36 Kar-Wai Hong, Chong-Lek Koh, Choon-Kook Sam, Wai-Fong Yin, Kok-Gan Chan. Complete Genome Sequence of Burkholderia sp. Strain GG4, a Betaproteobacterium That Reduces 3-oxo-N-acylhomoserine Lactones and Produces Different N-acylhomoserine Lactones.J. Bacteriol. November 2012 vol. 194 no. 22 6317. doi: 10.1128/JB.01578-12 37 Noraini Ahmad, Roland Ramsch, Jordi Esquena, Conxita Solans, Hairul Anuar Tajuddin, Rauzah Hashim. Physico-Chemical Characterization High Impact Research Annual Report 2012 of Natural-Like Branched-Chain Glycosides towards Formation of Hexosomes and Vesicles. Langmuir, 2012, 28 (5), 2395 2403. 38 Kar-Wai Hong, Chong-Lek Koh, Choon-Kook Sam, Wai-Fong Yin, Kok-Gan Chan. Whole Genome Sequence of N-acylhomoserine Lactone Synthesizing and Degrading Acinetobacter sp. Strain GG2. J. Bacteriol. November 2012 vol. 194 no. 22 6318. doi: 10.1128/JB.01579-12 39 Kar Wai Hong, Dinaiz a/l Thinagaran, Han Ming Gan, Wai- Fong Yin, Kok-Gan Chan. Whole genome sequencing of Cupriavidus sp. strain BIS7: a heavy metal resistant bacterium. J. Bacteriol. November 2012 vol. 194 no. 22 6324. doi: 10.1128/JB.01608-12 40 Soon Wei Chook1, Chin Hua Chia1*, Sarani Zakaria1, Mohd Khan Ayob2, Kah Leong Chee2, Nay Ming Huang3, Hui Min Neoh4, Hong Ngee Lim5. Antibacterial Performance of Ag Nanoparticles and AgGO nanocomposites prepared via rapid microwave-assisted synthesis method. Nanoscale Research Letters 2012, 7:541 41 BhooPathy N, Uiterwaal CS, Taib NA,Verkooijen HM, Yip CH. Gradually implemented new biomarkers for prognostication of breast cancer: complete case analysis may introduce bias. J ClinEpidemiol. 2012;65(5):568-71. 42 BhooPathy N, Hartman M, Yip C, Saxena N, Taib NA, SiewEng Lim SE, Philip Iau P, HansOlovAdami, Bulgiba AM, Lee SC, Verkooijen HM. Ethnic differences in survival after breast cancer in South East Asia. PLOS One. 2012; 7(2):e30995 (Tier 1 IF 4.4) 43 Bhoo-Pathy N, Yip CH, Hartman M, Saxena N, Taib NA, Ho GF, Looi LM, Bulgiba AM, van der Graaf Y, Verkooijen HM. Adjuvant! Online is overoptimistic in predicting survival of Asian breast cancer patients. Eur J Cancer. 2012; 48(7):982-9. (Tier 1 IF 4.8) 44 CheeEePhua, Anita ZarinaBustam, MasturaMdYusof, MarnizaSaad, Cheng-Har Yip, Taib NA and Char Hong Ng. Risk of treatment related death (TRD) with adjuvant chemotherapy for breast cancer: A study in University Malaya Medical Centre (UMMC). Journal of Cancer Therapeutics & Research. 2012; 1(13). 45 Dahlui M, Gan DE, Taib NA, Pritam R, Lim J. Predictors of Breast Cancer Screening uptake: A pre-intervention community survey in Malaysia. Asian Pac J Cancer Prev. 2012; 13(7): 3443-9. 46 Mujar M, Dahlui M, Yip CH, Taib NA. Delays in time to primary treatment after a diagnosis of breast cancer: Does it impact survival? 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Triple-negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer, but not in women with isolated late-onset breast cancer.Breast Cancer Res. 2012 Nov 2;14(6):R142 53 N BhooPathy, CH Yip, M Hartman, CSP Uiterwaal, BCR Devi, PHM Peeters, NA Taib, CH van Gils, HM Verkooijen. Breast cancer research in Asia: Adopt or adapt Western knowledge? European J Cancer. 2012. 54 Ng KH, Yip CH and Taib NA.Breast density speaks volumes - an argument for the standardisation of clinical breast density measurement based on 3D data. Lancet Oncol. 2012;13(4):334-6. (Tier 1) 55 Saxena N, Hartman M, Yip CH, Bhoo-Pathy N, Khin LW, Taib NA, Looi LM, Lim SE, Lee SC, Verkooijen HM. Does the Axillary Lymph Node Ratio Have Any Added Prognostic Value over pNStaging for South East Asian Breast Cancer Patients?PLoS One. 2012; 7(9):e45809. 56 Saxena N, Hartman M, Bhoo-Pathy N, Lim JN, Aw TC, Iau P,Taib NA, Lee SC, Yip CH,Verkooijen HM. Breast Cancer in South East Asia: Comparison of Presentation and Outcome Between a Middle Income and a High Income Country.World J Surg. 2012 57 Yip CH, Taib NA. Challenges in the management of breast cancer in low- and middle-income countries.Future Oncol. 2012 Dec;8(12). 58 Sarmani, AR; Abu Bakar, MH; Adikan, FRM; Mahdi, MA, ‘Laser Parameter Variations in a Rayleigh Scattering- Based Raman Fiber Laser With Single Fiber Bragg Grating Reflector’, IEEE PHOTONICS JOURNAL Volume: 4 51 52 High Impact Research Annual Report 2012 Issue: 2 Pages: 461-466 DOI: 10.1109/ JPHOT.2012.2190925 Published: APR 2012 (ISICited Publication) 59 Abu Bakar, MH; Adikan, FRM; Mahdi, MA, ‘Rayleigh-based Raman fiber laser with passive erbium-doped fiber for secondary pumping effect in remote L-band erbium-doped fiber amplifier,’ IEEE Photonics Journal, Vol. 4, No. 3, pp. 10421050, June 2012 (ISI-Cited Publication) 60 Y. G. Shee, M. H. Al-Mansoori, S. Yaakob, A. Man, A. K. Zamzuri, F. R. M. Adikan, and M. A. Mahdi, “Millimeter wave carrier generation based on a double-Brillouin- frequency spaced fiber laser,” Optics Express, vol. 20, pp. 13402-13408, 2012 (ISI-Cited Publication) 61 D. C. Tee, T. Kambayashi, S. R. Sandoghchi, N. Tamchek, F. R. Mahamd Adikan, ‘Efficient, wide angle, structure tuned 1x3 photonic crystal power splitter at 1550nm for triple play applications’, Journal of Lightwave Technology, Vol. 30, No. 17, pp. 2870-2875, Sept. 2012 (ISICited Publication) 62 Hisham, H.K., Mahdiraji, G.A., Abas, A.F., Mahdi, M.A., Adikan, F.R.M., ‘Characterization of TurnOn Time Delay in a Fiber Grating Fabry-Perot Laser’, IEEE Photonics Journal, Vol. 4, No. 5, pp. 1662-1678, Oct. 2012 (ISI-Cited Publication) 63 Hassan, Muhammad R.A.; Bakar, Muhammad H.A.; Dambul, Katrina; Adikan, Faisal R.M. 2012. “Optical-Based Sensors for Monitoring Corrosion of Reinforcement Rebar via an Etched Cladding Bragg Grating.” Sensors 12, no. 11: 1582015826. 64 Sumiaty Ambran, Christopher Holmes, James C. Gates, Andrew S. Webb, Lewis G. Carpenter, Faisal R. Mahamd Adikan, Peter G. R. Smith, and Jayanta K. Sahu, ‘Fabrication of a Multimode Interference Device in a Low Loss Flat-fiber Platform using Physical Micromachining Technique’, IEEE Journal of Lightwave Technology (accepted for publication 2012);(ISICited Publication) 65 Adikan, F.R.M.; Sandoghchi, S.R.; Chong Wu Yi; Simpson, R.E.; Mahdi, M.A.; Webb, A.S.; Gates, J.C.; Holmes, C.; , “Direct UV Written Optical Waveguides in Flexible Glass Flat Fiber Chips,” Selected Topics in Quantum Electronics, IEEE Journal of , vol.18, no.5, pp.1534-1539, Sept.Oct. 2012 66 Ghomeishi, Mostafa; Karami, Mohammad; Adikan, Faisal Rafiq Mahamd; , “Developing small vacuum spark as an x-ray source for calibration of an x-ray focusing crystal spectrometer,” Review of Scientific Instruments , vol.83, no.10, pp.103110-103110-5, Oct 2012 67 Al-Fakih, E.; Abu Osman, N.A.; Mahamd Adikan, F.R. “The Use of Fiber Bragg Grating Sensors in Biomechanics and Rehabilitation Applications: The State-of-the-Art and Ongoing Research Topics.” Sensors 2012, 12, 12890-12926. 68 Siew Woh Choo,Yan Ling Wong,Mee Lian Leong,Hamed Heydari,Chia Sui Ong,Kee Peng Ng,and Yun Fong Ngeow. Analysis of the genome of Mycobacterium abscessus strain M94 reveals an uncommon cluster of tRNAs. Journal of Bacteriology.2012 Oct;194(20):5724 69 Siew Woh Choo,Aini Mohamed Yusoff,Yan Ling Wong,Wei Yee Wee,Chia Sui Ong,Kee Peng Ng,and Yun Fong Ngeow. Genome Analysis of Mycobacterium massiliense strain M172 with a putative mycobacteriophage. 2012 Sep;194(18):5128. doi: 10.1128/JB.01096-12 70 Siew Woh Choo,Yan Ling Wong, Joon Liang Tan, Chia Sui Ong, Kee Peng Ng and Yun Fong Ngeow. Draft Genome Sequence of Mycobacterium bolletii Strain M24, a rapidly growing mycobacterium of contentious taxonomic status. Journal of Bacteriology. J. Bacteriol. 2012 Aug;194:4475. 71 Siew Woh Choo, Yan Ling Wong,Aini Mohamed Yusoff,Mee Lian Leong,Guat Jah Wong,Chia Sui Ong,Kee Peng Ng and Yun Fong Ngeow. Genome Sequence of the Mycobacterium abscessus Strain M93. Journal of Bacteriology.2012 Jun; 194(12):3278. 72 Siew Woh Choo,Yan Ling Wong,Joon Liang Tan,Chia Sui Ong, Guat Jah Wong,Kee Peng Ng,and Yun Fong Ngeow. Annotated genome sequence of Mycobacterium massiliense strain M154, belonging to the recently created taxon,Mycobacterium abscessus subspecies bolletii comb. Nov Journal of Bacteriology. 2012 Sep;194(17):4778. doi: 10.1128/JB.01043-12. 73 Yun Fong Ngeow, Yan Ling Wong, Joon Liang Tan, Ramitha Arumugam, Guat Jah Wong, Chia Sui Ong, Kee Peng Ng and Siew Woh Choo. Genome Sequence of Mycobacterium massiliense M18 isolated from a lymph node biopsy. J. Bacteriol. 2012 Aug ;194:4125. 74 Yun Fong Ngeow,Yan Ling Wong,Naline Lokanathan,Guat Jah Wong,Chia Sui Ong,Kee Peng Ng, and Siew Woh Choo. Genomic analysis of Mycobacterium massiliense strain M115, an isolate from human sputum. 2012 Sep;194(17):4786. doi: 10.1128/JB.01104-12. 75 Yun Fong Ngeow, Wei Yee Wee, Yan Ling Wong, Joon Liang Tan, Chia Sui Ong, Kee Peng Ng, and Siew Woh Choo.Genomic analysis of Mycobacterium abscessus strain M139 with an ambiguous subspecies taxonomic position. Journal of Bacteriology.2012 Nov;194(21):60023. doi: 10.1128/JB.01455-12. 76 Yun Fong Ngeow, Yan Ling Wong, Joon Liang Tan, Chia Sui Ong, Kee Peng Ng and Siew Woh Choo. Genome Sequence of the Mycobacterium abscessus strain M152. Journal of Bacteriology. 2012 Dec;194 (23): 6662 HIR 2 YEARS PROJECT 2010 1 Appanna R,Ponnampalvanar S, Lum LCS, Sekaran SD. Susceptible and protective HLA class 1 alleles against dengue fever and dengue hemorrhagic fever patients in a Malaysian population. PloS ONE (2010)5(9):e13029. doi:10.1371/journal.pone.0013029 High Impact Research Annual Report 2012 2 Ayu SM, Lai LR, Chan YF, Hatim A, Hairi NN, Ayob A , Sam IC. Seroprevalence survey of Chikungunya virus in Bagan Panchor, Malaysia. Am J. Trop Med Hyg. 2010 Dec;83(6):1245-8. 3 Wee, C. Y., & Raveendran Paramesran,(2010). Image Quality Assessment by Discrete Orthogonal Moments, Pattern Recognition. Vol.43, No.12, pp 4055-4068. 4 Zheng-Ming, Chuah ,Raveendran Paramesran, Kavintheran, Thambiratnam , Sin-Chew, Poh, (2010). A two-level partial least squares system for non-invasive blood glucose concentration prediction, Chemometrics and Intelligent Laboratory Systems. Vol. 104, No.2, pp 347-351. 5 Alhoot MA, Wang SM, Sekaran SD. Inhibition of Dengue Virus Entry and Multiplication into Monocytes Using RNA Interference. PloS Negi Trop Dis (2011) 5 (11):e1410.doi:10.1371/journal. pntd.0001410 6 Chan YF, Sam IC, Wee KL, AbuBakar S. (2011). Enterovirus 71 in Malaysia: A decade later. Neurology Asia 16: 1 – 15. 7 Huang, N.M., Lim, H.N., Chia, C.H., Yarmo, M.A. and Muhamad, M.R. 2011. Simple roomtemperature preparation of high-yield largearea graphene oxide. International Journal of Nanomedicine 6: 3443-3448. 8 Urawa S, Freeman MA, Johnson SC, Jones SRM, Yokoyama H. Geographical variation in spore morphology, gene sequences and host specificity of Myxobolus arcticus (Myxozoa) infecting salmonid nerve tissues. Dis. Aquat. Org. 2011 Oct;96:229-237 9 Sam IC, Chua CL, Chan YF. Chikungunya virus diagnosis in the developing world: a pressing need. Expert Review of Anti-Infective Therapy 2011; 9: 1089-1091. 10 Nazir R, Mazhar M, Wakeel T, Akhtar MJ, Siddique M, Nadeem M, Khan NA, Shah R. Pyrolysis Mechanism of Trisbipyridineiron(II) Chloride to Iron Nanoparticles. J. Therm Anal Calorim (2011) DOI:10.1007/s10973-011-1919-5 11 Nazir R, Mazhar M, Wakeel T, Akhtar MJ, Siddique M, Nadeem M, Khan NA, Shah R. Pyrolysis Mechanism of Trisbipyridineiron(II) Chloride to Iron Nanoparticles. J. Therm Anal Calorim (2011) DOI:10.1007/s10973-011-1919-5. 12 Chern-Loon Lim, Barmark Honarvar, Kim Han Thung, Raveendran Paramesran,(2011). Fast computation of exact Zernike moments using cascaded digital filters. Journal Information Sciences, Vol. 181, No.17, pp 3638-3651. 13 Lim, C.K. and Chan, C.S. Logical Connectives and Operativeness of BK Sub-triangle Product in Fuzzy Inferencing, International Journal of Fuzzy Systems. 2011: 13(4):237-245 14 Razali R, Zak AK, Abd Majid WH, Darroudi M, Solvothermal synthesis of microsphere ZnO nanostructures in DEA media, Ceram Int. 2011 Dec; 37: 3657-3663. 15 Romano Ngui, Saidon Ishak, Chow Sek Chuen, Rohela Mahmud & Yvonne Lim Ai Lian (2011). Prevalence and risk factors of intestinal parasitism in rural and remote West Malaysia. Plos NTD 5 (3): e974. 16 Romano Ngui, Yvonne A. L. Lim, Noor Farahani Amir,Veeranoot Nissapatorn and Rohela Mahmud (2011). Seroprevalence and sources of toxoplasmosis among Orang Asli (Indigenous) Communities in Peninsular Malaysia. American Journal of Tropical Medicine and Hygiene 85(4): 660-666. 17 Zak AK, Razali R, Abd Majid WH, Darroudi M, Synthesis and characterization of narrow size distribution of zinc oxide nanoparticles. Int. J. Nanomed. 2011 Jul; 6: 1399–1403. 18 Zak AK, Gan WC, Abd Majid WH, Darroudi M, Experimental and Theoretical Dielectric Studies of PVDF/PZT Nanocomposite Thin Films. Ceram Int. 2011 Jul; 37: 1653-1660 19 Velayutham TS, Abd Majid WH, Ahmad AB, Gan SN, Electrical behaviour of polyurethane derived from polyols synthesized with glycerol, phthalic anhydride and oleic acid. J. Appl. Polym. Sci. 2011 Aug; 121: 1796-1803. 20 Zak AK, Abd Majid WH, Effect of solvent on structure and optical properties of PZT nanoparticles prepared by sol–gel method, in infrared region. Ceram Int. 2011 Apr; 37: 753-758. 21 Zak AK, Abd Majid WH, Abrishami ME, Yousefi R, Hosseini SM, X-ray analysis of ZnO nanoparticles by Williamson–Hall and size–strain plot methods. Solid State Sci. 2011 Jan; 13: 251-256 22 Zak AK, Abd Majid WH, Abrishami ME, Yousefi R, Hosseini SM, Effects of annealing temperature on some structural and optical properties of ZnO nanoparticles prepared by a modified sol–gel combustion method. Ceram Int. 2011 Jan; 37(1): 393-398. 23 Zak AK, Abd Majid WH, Darroudi M, Yousefi R, Synthesis and characterization of ZnO nanoparticles prepared in gelatin media. Mater. Lett. 2011 Jan; 65(1): 70-73. 24 Tan CW, Chan YF, Sim KM, Tan EL, Poh CL. (2012). Inhibition of Enterovirus 71 (EV-71) Infections by a Novel Antiviral Peptide derived from EV-71 Capsid Protein VP1. PLOS One. 7:5. 25 Sam IC, Loong SK, Michael JC, Chua CL, Wan Sulaiman WY, Vythilingam I, Chan SY, Chiam CW, Yeong YS, AbuBakar S, Chan YF. Genotypic and phenotypic characterization of Chikungunya virus of different genotypes from Malaysia. PLoS One 2012; 7: e50476. 26 Rubio-Godoy M, Paladini G, Freeman MA, García-Vásquez A, Shinn AP. Morphological and molecular characterisation of Gyrodactylus salmonis (Platyhelminthes, Monogenea) collected in Mexico from rainbow trout (Oncorhynchus mykiss Walbaum). Vet. Parasitol. 2012 May;186(3-4):289-300 27 Caruana S, Yoon GH, Freeman MA, Mackie JA, Shinn AP. The efficacy of selected plant extracts and bioflavonoids in controlling infections of Saprolegnia australis (Saprolegniales; Oomycetes). Aquaculture 2012 Aug;358359:146–154. 53 54 High Impact Research Annual Report 2012 28 Vijay Kumar, S., Huang, N.M., N. Yusoff, Lim, H.N., 2012. High Performance Magnetically Separable Graphene/Zinc Oxide Nanocomposite. Materials Letters. Accepted. 39 P.S. Lim, H. N. Lim, N. M. Huang, C. H. Chia, I. Harrison. 2012. Room temperature in situ synthesis of Fe3O4/graphene nanocomposites. Ceramics International. 38: 6411-6416. 29 Appanna R, Wang SM,Ponnampalavanar SA, Lum LCS, Sekaran SD. Cytokine Factors Present in Dengue Patient Sera Induces Alterations of Junctional Proteins in Human Endothelial Cells. AM J Trop Med Hyg (2012) 87:936-942 40 B.Y.S. Chang, N.M. Huang, M.N. An’ amt, M.A. Rahman, N. Yusoff, M.R. Muhamad, I. Harrison, C. H. Chia. 2012. Facile hydrothermal preparation of titanium dioxide decorated reduced graphene oxide nanocomposite. International Journal of Nanomedicine. 2012(7):1-9. 30 Arof, A.K., Kufian, M.Z., Syukur, M.F., Aziz, M.F., Abdelrahman, A.E., Majid, S.R, Electrical double layer capacitor using poly(methyl methacrylate)-C 4BO 8Li gel polymer electrolyte and carbonaceous material from shells of mata kucing (Dimocarpus longan) fruit, Electrochimica Acta 74 (2012) pp. 39-45 31 Rathakrishnan A, Wang SM, Hu Y, Khan AM, Ponnampalavanar S, Lum LCS, Manikam R, Sekaran SD. Cytokine Expression Profile of Dengue Patients at Different Phases of Illness. PloS ONE (2012) 7(12);e52215. doi: 10.1371/ journal.pone.0052215 32 Zurina Osman, Siti Mariam Samin, Lisani Othman and Khairul Bahiyah Md Isa, “Ionic Transport in PMMA-NaCF3SO3 Gel Polymer Electrolytes”, Advanced Materials Research, 545(2012), 259263. 33 Z.Osman, M.I. Mohd Ghazali, L. Othman, K.B. Md Isa, “AC ionic conductivity and DC polarization method of lithium ion transport in PMMA–LiBF4 gel polymer electrolytes, Results in Physics, 2(2012), 1-4. 34 Chong CE, Lim KP, Gan CP, Marsh CA, Zain RB, Abraham MT, Prime SS, Teo SH, Silvio Gutkind J, Patel V, Cheong SC. Over-expression of MAGED4B increases cell migration and growth in oral squamous cell carcinoma and is associated with poor disease outcome. Cancer Lett. 2012 Aug;321(1):18-26 (Tier 1, Impact factor-4.238) 35 Golsheikh, A.M., Huang, N.M., Lim, H.N., Chia, C.H., Harrison, I. and Muhamad, M.R. 2012. One-pot hydrothermal synthesis and characterization of FeS2 (pyrite)/graphene nanocomposite. Chemical Engineering Journal Accepted. 36 Vijay Kumar, S., Huang, N.M., Lim, H.N., Marlinda, A.R., Harrison, I. and Chia, C.H. 2012. One-step size-controlled synthesis of functional graphene oxide/silver nanocomposite at room temperature. Chemical Engineering Journal Accepted. 37 Chook, S.W. C.H. Chia, S. Zakaria, M.K. Ayob, K.L. Chee, N.M. Huang, H.M. Neoh, H.N. Lim, R. Jamal, R.M.F.R.A. Rahman. 2012. Antibacterial Performance of Ag Nanoparticles and AgGO nanocomposites prepared via rapid microwaveassisted synthesis method. Nanoscale Research Letter. 7: 541. 38 Zainy, M., Huang, N.M., Vijay Kumar, S. and Lim, H.N. 2012. Simple and scalable preparation of reduced graphene oxide-silver nanocomposites via rapid thermal treatment. Materials Letters 89: 180-183. 41 Vincent-Chong VK, Ismail SM, Rahman ZA, Sharifah NA, Anwar A, Pradeep PJ, Ramanathan A, Karen-Ng LP, Kallarakkal TG, Mustafa WM, Abraham MT, Tay KK, Zain RB. Genome-wide analysis of oral squamous cell carcinomas revealed over expression of ISG15, Nestin and WNT11. Oral Dis. 2012 Jul;18(5):469-76. (Tier 1, Impact factor- 2.495) 42 M.A. Rahman, N. Yusoff, M.R. Muhamad, I. Harrison, M.N. An’ amt, B.Y.S. Chang, N. M. Huang. 2012. Highly efficient preparation of ZnO/reduced graphene oxide nanocomposites. Materials Letters 80:9-12 43 Lim, H.N., Huang, N.M. and Loo, C.H. 2012. Facile preparation of graphene-based chitosan films: Enhanced thermal, mechanical and antibacterial properties. Journal of NonCrystalline Solids 358: 525-530. 44 Alhoot MA, Wang SM, Sekaran SD. RNA Interference Mediated Inhibition of Dengue Virus Multiplication and Entry in HepG2 Cells. PloS ONE (2012) 7(3):e34060.doi:10.1371/journal. pone.0034060 45 Vincent-Chong VK, Anwar A, Karen-Ng LP, Cheong SC, Yang Y-H, Pradeep PJ, Rahman ZAA, Ismail SM, Zaini ZM, Prepageran N, Kallarakkal TG, Ramanathan A, Mohayadi NABM, Rosli NSBM, Mustafa WMW, Mannil TA, Tay KK, Zain RB. Genome Wide Analysis of Chromosomal Alterations in Oral Squamous Cell Carcinomas Revealed Over Expression of MGAM and ADAM9. PloS One (2012) (Accepted) (Tier 1, Impact factor-4.092) 46 Zanaruddin SN, Saleh A, Yang YH, Hamid S, Mustafa WM, Khairul Bariah AA, Zain RB, Lau SH, Cheong SC. Four-protein signature accurately predicts lymph node metastasis and survival in oral squamous cell carcinoma. Hum Pathol. 2012 [Epub ahead of print] (Tier 2, Impact factor- 2.876) 47 Tan CW, Poh CL, Sam IC, Chan YF (2012). Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor. Journal of Virology 87-611-620. 48 Kah-Hyong Chang; Raveendran Paramesran, Senior Member, IEEE; Barmak Honarvar Shakibaei Asli; Chern-Loon Lim, (2012) “Efficient Hardware Accelerators for the Computation of Tchebichef Moments”,IEEE Transaction on Circuit, System, and Video Technology. Vol 22, No. 3, pp 414-425. 49 Kim Han Thung, Raveeendran Paramesran, and Chern Loon Lim,(2012). Content Based High Impact Research Annual Report 2012 Image Quality Metric using Similarity Measure of Moment Vectors, Pattern Recognition. Vol 45, No.6, pp 2193-2204. 50 Wong LP. Qualitative Inquiry into Premarital Sexual Behaviours and Contraceptive Use among Multiethnic Young Women: Implications for Education and Future Research.PLoS ONE (2012) 7 (12): e51745. DOI:10.1371/journal.pone. 0051745 51 Wong LP. An exploration of knowledge, attitudes and behaviours of young multiethnic Muslimmajority society in Malaysia in relation to reproductive and premarital sexual practices. BMC Public Health. 2012; 12:865 52 Tan, W.R.; Chan, C.S.; Yogarajah, P. and Condell, J. A Fusion Approach for Efficient Human Skin Detection, IEEE Transactions on Industrial Informatics. 2012; 8(1):138-147. crosslinking on the properties of palm oil-based polyurethane coatings. J. Appl. Polym. Sci. (2012) DOI: 10.1002/app.38768 61 Zak AK, Yousefi R, Abd Majid WH, Muhamad MR, Facile synthesis and X-ray peak broadening studies of Zn1-xMgxO nanoparticles. Ceram Int. 2012 Apr; 38: 2059-2064. 62 Zak AK, Abd Majid WH, Mahmoudian MR, Darroudi M, Yousefi R, Starch-stabilized synthesis of ZnO nanopowders at low temperature and optical properties study. Adv. Powder Technol. (2012) DOI:org/10.1016/j. apt.2012.11.008 63 Zak AK, Abd Majid WH, Darroudi M, Facile synthesis and characterization of Lanthanum (III) Oxychloride nanoparticles in natural polymer matrix, Mater. Chem. Phys. 2012 Oct; 136 (2-3): 705-709. 53 Chan Y.F., Wee, K.L., Chiam, C.W., Khor, C.S., Chan, S.Y., Wan Nor Amalina W.M.Z., Sam, I.C. (2012). Comparative Genetic Analysis of VP4, VP1 and 3D Gene Regions of Enterovirus 71 and Coxsackievirus A16 Circulating in Malaysia between 1997-2008. Tropical Biomedicine 29: 451-466. 64 Zak AK, Abd Majid WH, Abrishami ME, Darroudi M, Synthesis and X-ray analysis of Zn0.97X0.03O nanoparticles (X=Mn, Ni, and Co) using Scherrer and size-strain plot methods. Solid State Sci. 2012 Apr; 14: 488-494. 54 Arafat MM, Dinan B, Akbar SA, Haseeb ASMA. Gas Sensor Based on One Dimentional Nanostructured Metal Oxides: A Review. Sensors (2012) DOI:10.3390/s120607207 HIR 2 YEARS PROJECT 2011 55 Pukana Jayaraman, Prakash Nathan, Punitha Vasanthan, Sabri Musa, Vijayendran Govindasamy. Stem cells conditioned medium: A new approach to skin wound healing management. Wound Repair and Regeneration. (Submitted on 20 December 2012). 56 Romano Ngui, Yvonne A.L. Lim, Liam Chong Kin, Chow Sek Chuen, Shukri Jaffar (2012). Association between anaemia, iron deficiency anaemia, neglected parasitic infections and socioeconomic factors in rural children of West Malaysia. PLoS Neglected Tropical Diseases 6(3): e1550. doi:10.1371/journal.pntd.0001550. 57 Romano Ngui, Yvonne A.L. Lim, Rebecca Traub, Rohela Mahmud, Mohd Sani Mistam (2012). Epidemiological and genetic data supporting the transmission of Ancylostoma ceylanicum among human and domestic animals. PloS Neglected Tropical Diseases 6(2): e1522. doi:10.1371/ journal.pntd.0001522. 58 Romano Ngui, Lee Soo Ching, Tan Tiong Kai, Muhammad Aidil Roslan, Yvonne AL Lim (2012). Genetic characterisation of human hookworm infections in rural and remote areas of Peninsular Malaysia. American Journal of Tropical Medicine and Hygiene. In Press. 59 Velayutham TS, Abd Majid WH, Gan WC, Zak AK, Gan SN, Theoretical and experimental approach on dielectric properties of ZnO nanoparticles and polyurethane/ZnO nanocomposites. J. Appl. Phys. 2012 Sep; 112: 054106. 60 Velayutham TS, Abd Majid WH, Ng BK, Gan SN, Effect of oleic acid content and chemical 1 Ayu SM, Lai LR, Chan YF, Hatim A, Hairi NN, Ayob A , Sam IC. Seroprevalence survey of Chikungunya virus in Bagan Panchor, Malaysia. Am J. Trop Med Hyg. 2010 Dec;83(6):1245-8. 2 Nazir R, Mazhar M, Wakeel T, Akhtar MJ, Siddique M, Nadeem M, Khan NA, Shah R. Pyrolysis Mechanism of Trisbipyridineiron(II) Chloride to Iron Nanoparticles. J. Therm Anal Calorim (2011) DOI:10.1007/s10973-011-1919-5 3 S.S. Lee, N.H. Tan, S.Y. Fung, J. Pailoor, S.M. Sim (2011) Evaluation of the sub-acute toxicity of the sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk mushroom, Journal of Ethnopharmacology , 138:192-200. 4 Chow WZ, Al-Darraji H, Lee YM, Takebe Y, Kamarulzaman A, Tee KK. Genome sequences of a novel HIV-1 circulating recombinant form (CRF) 53_01B identified in Malaysia. J Virol 2012; 86(20):11398-11399 5 Ng KT, Ong LY, Takebe Y, Kamarulzaman A, Tee KK. Genome sequences of a novel HIV1 circulating recombinant form 54_01B from Malaysia. J Virol 2012; 86(20):11405-11406 6 Pai YJ, Abdullah NL, Mohd-Zin SW, Mohammed RS, Rolo A, Greene ND, Abdul-Aziz NM, Copp AJ. (2012) Epithelial fusion during neural tube morphogenesis.Birth Defects Res A Clin Mol Teratol. 2012 Oct;94(10):817-23. 7 Chowdhary R, Street C, Travassos da Rosa A, Nunes MR, Tee KK, Hutchison SK, Vasconcelos PF, Tesh RB, Lipkin WI, Briese T. Genetic characterization of the Wyeomyia group of orthobunyaviruses and their phylogenetic relationships. J Gen Virol 2012; 93(Pt. 5):10231034. 55 56 High Impact Research Annual Report 2012 8 Tee KK, Kamarulzaman A, Matano T, Takebe Y. Phylodynamic inference of infectious diseases caused by the human immunodeficiency virus, enterovirus 71, and the 2009 swine-origin human influenza virus. Future Virol 2012; 7(4):403-412. (Review Article) 9 Tan, N.H. Fung, S.Y. and Yeannie Yap H.Y. (2012). Isolation and characterization of the thrombinlike enzyme from Cryptelytrops albolabris (white-lipped tree viper) venom. Comp. Biochem. Physiol. B. 161, 79-85.) 10 Tan K H, Ahmad R, Johan M R, Electromagnetic and microwave absorbing properties of amorphous carbon nanotube-cadmium selenide quantum dot hybrids, Material Chemistry and Physics (2012). 11 Leong, P.K., Sim, S.M., Fung, S.Y., Sumana, K., Sitprija, V. Tan, N.H. (2012). Cross neutralization of Afro-Asian cobra and Asian krait venoms by a Thai polyvalent snake antivenom (Neuro polyvalent snake antivenom). PloS Neglected Tropical Diseases, 6, e1672. 12 Maria Szkudlarek-Mikho, Rudel A. Saunders, Sook Fan Yap, Yun Fong Ngeow, Khew-Voon Chin. Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis. Biochemical and Biophysical Research Communications.2012 Oct 31. pii: S0006-291X(12)02072-4. doi: 10.1016/j. bbrc.2012.10.080. [Epub ahead of print] IF:2.484 Tier 1 for Biophysics 13 Hidayah Mohd Khalid, Iswadi Jauhari, Adibah Haneem Mohamad Dom. Development of nanolayer HA on titanium alloy via superplastic deformation method. Metallurgical and Materials Transactions A. 2012 Oct ;43 (10): 3776-3785 14 Nor Wahida Ahamad and Iswadi Jauhari. Carburizing of duplex stainless steel (DSS) under compression superplastic deformation. Metallurgical and Materials Transactions A. 2012 Dec;43(13):5115-5121 15 Sharidah Azuar Abdul Azis, Iswadi Jauhari, Nor Wahida Ahamad Improving surface properties and wear behaviors of duplex stainless steel via pressure carburizing. Surface and Coating Technology. 12 September 2012;(210):142-150 16 Lee, M.L., Tan,N.H., Fung, S.Y., Tan, C.S. and Ng, S.T. (2012) The anti-proliferative activity of sclerotia of Lignosus rhinocerus (tiger milk mushroom). Evidence- Based Complementary and Alternative Medicine Volume 2012 (2012), Article ID 697603, 5 pages doi:10.1155/2012/697603 17 Abdul-Rahman, H., Wang, C., Woods, L., Low, S.F. (2012). Negative Impact Induced by Foreign Workers: Evidence in Malaysian Construction Sector. Habitat International. 36: 433-443. (ISI Indexed Journal, 2011 impact factor=1.434, TIER 1). 18 Jiram A, vythilingam I, Noor Azian MY,Yusri MY,Azahari AH,Fong MY. Entomologic investigation of Plasmodium knowlesi vectors in Kuala Lipis, Pahang. Malaysia Mal J. 2012 11:213 19 M.A.Kamarudin, A.Z.S.Zulkifli, S.M.Said. A Review on the gel polymer electrolytes for Dye-sensitized solar cell applications. J of Pwr Sources (2012), POWER-D-12-02989. LIST OF PRESENTATIONS HIR MOHE 2012 BY FACULTY FACULTY OF MEDICINE 1 Mokhtar AS, Tay ST (2010). First detection of Rickettsia felis, Bartonella hensale and B. clarridgeiae from cat fleas (Ctenocephalides felis) in Malaysia. Poster presented at the 15th Biological Sciences Graduate Congress held from 15-17th December 2010 at University of Malaya. Mokhtar et al. (2011). Oral presentation on 4th March 2011 at teh 47th Annual Conference of the Malaysian Society of Parasitology and Tropical Medicine at International Medical University, Malaysia. 2 Umar Yagoub, Awang M Bulgiba, Didi EM, Mustafa AM, Peramalah D, Christopher Lee, Chik Z; Measuring adherence to Highly Active Antiretroviral Treatment in HIV positive patients in Sungai Boluh Hospital. Oral presentation in APACPH 2010 in Bali Indonesia 3 Hun-Wei Ooi, Sazaly AbuBakar, Li-Yen Chang. Molecular cloning and transfection studies of Nipah virus V gene. International Conference of the Malaysian Society for Microbiology, Bayview Resort Penang, 9 - 11 Dec 2011 (Poster presentation) 4 Vunjia Tiong, Chui-Wan Lam, Hun-Wei Ooi, WaiHong Phoon, Min-Han Lew, Sazaly AbuBakar, Li-Yen Chang. Production of recombinant Nipah virus proteins and its application in diagnosis of a relapse case of Nipah virus infection. International Conference of the Malaysian Society for Microbiology, Bayview Resort Penang, 9 - 11 Dec 2011 (Poster presentation) 5 Vellasamy KM, Mariappan V, Hashim OH, Vadivelu J. The role of live bacteria and secretory proteins of Burkholderia pseudomallei in host pathogen interactions. International Congress of The Malaysian Society for Microbiology 2011, 8-11 December, 2011, Penang, Malaysia. Proceeding International Congress of the Malaysian Society for Microbiology 2011. Abstract no MM1; pp261 High Impact Research Annual Report 2012 6 Ong GH, Chang LY, Vadivelu J. Isolation and characterisation of environmental Burkholderia pseudomallei bacteriophages. International Congress of The Malaysian Society for Microbiology 2011, 8-11 December, 2011, Penang, Malaysia. Proceeding International Congress of the Malaysian Society for Microbiology 2011. Abstract no MM10; pp395 7 Kang WT, Vellasamy KM, Chua EG, Vadivelu J. Functional characterisation of type III secretion system-3 effector protein BipC in Burkholderia pseudomallei pathogenesis. International Congress of The Malaysian Society for Microbiology 2011, 8-11 December, 2011, Penang, Malaysia. Abstract no Oral MM4; pp63 8 N. Sangeetha, J.H. Wong, S.R. Kanthan, T. Ravindran and T. Kamarul. Histological, Biochemical and Biomechanical Evaluation of Osteoarthritic Induced Rat Models: Which Model is Superior?. Malaysian Orthopaedic Association. 41st MOA AGM/ASM & 5th ASEAN Arthroplasty Association Meeting. May 22nd -24th 2011, Kuala Lumpur. 9 Sim, MS; Sulaiman, AH; Jaafar, ANFA; Mohamed, Z. Association of SOD2 (superoxide dismutase 2) genetic polymorphisms with methamphetamine dependence in Malaysian population. Drug Metabolism Reviews 2011 May. 43:69-70 (ISICited Publication) 10 Integration of Pharmacology Knowledge into Clinical Practice, 8th Asia Pacific Medical Education Conference, 28 Jan 2011 to 29 Jan 2011, Medical Education Unit of the National University of Singapore, (International) 11 The Pharmacogenomics Approach to Personalised Medicine., 1st Malaysia Conference on Rare Disorders and Medical Genetics., 09 Jun 2011 to 10 Jun 2011, Human Variome Project Consortium, (National). Kuala Lumpur 12 Association study of tryptophan hydroxylase 2 and serotonin transporter genes with major depressive disorder in Malaysian ethnic subgroups, 2nd Congress of the Asian College of Neuropsychopharmacology, 23 Sep 2011 to 24 Sep 2011, Korean College of Neuropsychopharmacology and Neuroscience, (International). Seoul, Korea. 13 Pharmacogenomincs: Paving the Way to Personalised Medicine., MGRC s 12th Eminent Speaker Series. 23rd June 2011. Zahurin Mohamed (Invited Speaker)., 23 Jun 2011 to 23 Jun 2011, Malaysian Genome Research Centre, (National) 14 Association of ABCB1 polymorphisms with response to sodium valproate in Malaysian epilepsy patients., Asian Pacific International Society for Study of Xenobiotics (APISSX) 2011. 22-25th April 2011. Z Mohamed, BS Haerian, KS Lim, CT Tan (Oral Presentation)., 22 Apr 2011 to 25 Apr 2011, International Society for Study of Xenobiotics, (International). Taiwan. 15 Association of INSIG2 RS7566605 Polymorphism with obesity-related parameters in Malaysian Malays, Human Genome Meeting 2011, 14 Mar 2011 to 17 Mar 2011, HUGO and UAE, (International). Dubai, UAE. 16 Chiam CW, Chan YF, Ong KC, Wong KT, Sam IC. Neurovirulence variation of different Chikungunya virus genotypes in ICR suckling mice. 16th Biological Sciences Graduate Congress, National University of Singapore, Singapore, 12-13 December 2011 17 Helen-Ng LC, Razak IA, Ghani WMN, Marhazlinda J, Norlida A, Zain RB. Dietary consumption pattern and risk of oral cancer – a Malaysia scenario. 3rd World Congress of the International Academy of Oral Oncology, Yin and Yang: Balancing Cure and Consequences, 14-17 July 2011, Grand Copthorne Waterfront Hotel, Singapore. Oral Oncology Abstract no P98; pp 105. 18 Yap, M.K.K., Tan, N.H., Sim, S.M. and Fung, S.Y. (2011) Pharmacokinetics of Naja sputatrix (Javan spitting cobra) venom and the effect of a neurotoxic polyvalent antivenom. Paper presented at the 17th Congress of the European Section of the International Society of Toxinology, Sep 11th-15th, 2011. Valencia, Spain 19 Leong, P.K., Fung, S.Y., Sim, S.M. and Tan, N.H. (2011). Cross neutralization of some Southeast Asian cobra and krait venoms by Indian polyvalent antivenoms. Paper presented at the 17th Congress of the European Section of the International Society of Toxinology, Sep 11th15th, 2011. Valencia, Spain. 20 Umar Yagoub, Awang M Bulgiba, Didi EM, Mustafa AM, Peramalah D, Christopher Lee, Chik Z; Socio-demographic characteristics in HIV positive patients on HAART in Sungai Buloh Hospital. Poster presentation in APACPH in Seoul South Korea 2011 21 Choh LC, Ong GH, Wong KT, Vadivelu J. Dissecting the functional role of BapA protein in Burkholderia pseudomallei pathogenesis. International Congress of The Malaysian Society for Microbiology 2011, 8-11 December, 2011, Penang, Malaysia. Abstract no MM9; pp392 22 The Pharmacogenomics Approach to Personalised Medicine., 1st Malaysia Conference on Rare Disorders and Medical Genetics., 09 Jun 2011 to 10 Jun 2011, Human Variome Project Consortium, (National). Kuala Lumpur 23 Pharmacogenomincs: Paving the Way to Personalised Medicine., MGRC s 12th Eminent Speaker Series. 23rd June 2011. Zahurin Mohamed (Invited Speaker)., 23 Jun 2011 to 23 Jun 2011, Malaysian Genome Research Centre, (National) 24 Association of INSIG2 RS7566605 Polymorphism with obesity-related parameters in Malaysian Malays, Human Genome Meeting 2011, 14 Mar 2011 to 17 Mar 2011, HUGO and UAE, (International). Dubai, UAE. 25 Leong KH, Chung LY, Noordin MI, Onuki Y, Morishita M, Takayama K. Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery. Carb Polym. 2011, 86: 555-565. 57 58 High Impact Research Annual Report 2012 26 Choh LC, Wong KT, Vadivelu, J. Role of BapA involved in intracellular lifecycle of Burkholderia pseudomallei. The 17th Biological Sciences Graduate Congress 2012, 8-10 December, 2012, Bangkok, Thailand. The 17th Biological Sciences Graduate Congress Program and Abstracts. Abstract no. CMB-PO16; pp 195 27 Bioethics and Society, Launching of the National Bioethics Council and Presentaion of the Letter of Appointment by the Minister of Science, Technology and Innovation, YB Datuk Seri Panglima Dr Maximus Johnity Ongkili, 22 May 2012 to 23 May 2012, Ministry of Science, Technology and Innovation, (National) 28 Pharmacogenomics Studies in Multiethnic Malaysians, Symposium for Genetic and Genome Guided Personalized Medicine in Asia: Overview and Applications, 02 Feb 2012 to 03 Feb 2012. Bangkok, Thailand. Thailand Center of Excellence for Life Sciences (Public Organization) together with Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Department of Medical Sciences, Ministry of public Health,and RIKEN, Japan, (International) 29 Peripheral PDLIM5 Expression in bipolar disorder and the effect of olanzapine administration, 10th Asia Pacific Conference on Human Genetics, 05 Dec 2012 to 08 Dec 2012, Asia Pacific Society of Human Genetics, (International). Kuala Lumpur 30 Mariappan V, Vellasamy KM, Thimma J, Hashim OH, Vadivelu J. Differential Host gene expression upon exposure to live Burkholderia cepacia and its secretory proteins. 15th International Congress of Infectous Diseases, June 13-16, 2012, Bangkok, Thailand. Abstract no 45.049 35 Vellasamy KM, Mariappan V, Hashim OH, Vadivelu J. Burkholderia pseudomallei hostpathogen interactions: role of live bacteria and secretory proteins. 15th International Congress of Infectous Diseases, June 13-16, 2012, Bangkok, Thailand. Abstract no 46.061 36 Central adiposity and body composition as indicators of dyslipidaemia among adolescents in Kuala Lumpur: A case-control study, 26th Scientific Meeting of Malaysian Society of Pharmacology & Physiology, 18 May 2012 to 20 May 2012, Malaysian Society of Pharmacology and Physiology, (National) 37 Sabet Negar Shafiei, Gupta Rishein, ChingYew Beh, Abd-Jamil Juraina, Ngeow Yun-Fong, Sofiah Sulaiman, Jamiyah Hassan, Arulanandam Bernard P, AbuBakar Sazaly. Characterization of Genital Chlamydia Trachomatis Infections and Determination of Host Immune Responses In Malaysian Woman of Reproductive Age 5th Federation of Immunological Societies of AsiaOceania (FIMSA) Congress (March 14th-17th, 2012, New Delhi) Abstract N0 -330 -poster No130 38 One paper presented at the 17th Biological Science Graduate Congress at Chulalongkorn University, Bangkok, 8th-10th Dec 2012: Application of Suppression Subtractive Hybridization (SSH) to Generate Differential Genes in Mycobacterium tuberculosis (Mtb) isolates from Cerebrospinal Fluid (CSF) and Respiratory Secretions. Saw S.H., Ngeow Y.F., Yong V.C. and Ng H.F. 31 Wai-Hong Phoon, Sazaly AbuBakar, Li-Yen Chang. Construction and Expression of Nipah Virus Nucleocapsid Gene in Escherichia coli. Symposium of the Malaysian Society for Microbiology, Promenade Hotel Sabah, 12 - 15 Dec 2012 (Poster Presentation) 39 Wong KT, Ong KC, Ng KY, Radotra B, Shankar SK, Mahadevan A, Glatzel M, Sata T, Shuangshoti S, Robertson T. Cellular targers of virus infection in human rabies. 10th European Congress of Neuropathology, Edinburgh, Scotland, United Kingdom, 6-9 June 2012 (Abstract in Clinical Neuropathology 2012; 31: 305) 32 Vunjia Tiong, Sazaly AbuBakar, Li-Yen Chang. Permissiveness And Survivability Studies Of Nipah Virus Infection Of Human Monocytic Thp-1 Cells Suggest A Role In Virus Spread. Symposium of the Malaysian Society for Microbiology, Promenade Hotel Sabah, 12 - 15 Dec 2012 (Poster Presentation) 40 Wong KT, Tan SH, Ong KC. Cranial nerves are involved in viral entry into the brainstem in a mouse model of Enterovirus 71 encephalomyelitis. 10th European Congress of Neuropathology, Edinburgh, Scotland, United Kingdom, 6-9 June 2012 (Abstract in Clinical Neuropathology 2012; 31: 305-306) 33 Kalaiselvam K, Mariappan V, Vellasamy KM, NSK Ramli, Al-Maleki AR, Vadivelu J. Comparative proteomic analysis of large and small colony morphology variants of Burkholderia pseudomallei. The 1st Malaysian Proteomics Conference 2012, September 26-27, 2012, Penang, Malaysia. Asia-Pacific Journal of Molecular Medicine 2012, 2(Suppl 1), Abstract no PP07 41 Wong KT, Ng KY, Ong KC, Ng WF, Shankar SK, Mahadevan A, Radotra B, Su IJ, Lau G, Macorelles P. Enterovirus 71 and Japanese encephalitis can be distinguished by distribution of inflammation and intraneuronal detection of viral antigen and RNA. 10th European Congress of Neuropathology, Edinburgh, Scotland, United Kingdom, 6-9 June 2012 (Abstract in Clinical Neuropathology 2012; 31: 306) 34 Susceptibility and gene interaction study of the angiotensin II type I receptor gene with non-alcoholic fatty liver disease in a multiethnic population, 26th Scientific Meeting of the Malaysian Society of Pharmacology & Physiology, 18 May 2012 to 20 May 2012, Malaysian Society of Pharmacology & Physiology, (National) 42 K. T. Wong1, L. C. Eu1, K. C. Ong2, J. Vadivelu3, Sheila Nathan4. Development of a specific DNA probe that targets the 16s ribosomal RNA for the detection and identification of Burkholderia pseudomallei in infected tissues. XXIA International Congress of the International Acadmy of Pathology, Cape Town, South Africa, 30 sept – 5 Oct 2012 High Impact Research Annual Report 2012 43 Tan SH, Wong KT, Ong KC. Cranial nerves are involved in viral entry into the brainstem in a mouse model of Enterovirus 71 encephalomyelitis. International Environment and Health Conference 2012. Penang, Malaysia, 6-7 June 2012. 44 Siti Idayu H, Rusdi AR, Muhammad Muhsin AZ, Chong Guan N, Ahmad Hatim S, Fatimah I, Noor Zuraini R, Rahimah AK, Muna M, Mohamad Hussain H, Wan Azlinda Irnee WH. A study on the effectiveness of electroacupuncture as adjunctive treatment among methadone maintenance therapy clients in University of Malaysia Medical center, kuala Lumpur, Malaysia. Abstracts from the 28th CINP World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012. (2012). The International Journal of Neuropsychopharmacology, 15(SupplementS1), 1-271.doi:10.1017/ S1461145712000508. (ISI-cited publication). 45 Wan Azlinda Irnee WH, Siti Idayu H, Azhar S, Muna M,Rusdi AR, Mohamad Hussain H.Mohamad Hussain H. Amphetamine-type stimulants use among drug users on the street at Chow Kit Road, Kuala Lumpur, Malaysia. Abstracts from the 28th CINP World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012. (2012). The International Journal of Neuropsychopharmacology, 15(SupplementS1), 1-271. doi:10.1017/ S1461145712000508. (ISI-cited publication). 46 Pui-Fong Jee, Sazaly AbuBakar, Raha Abdul Rahim, Li-Yen Chang. Refolded Fusion Protein Consisting of the N-acetylmuraminidase (ACMA) Anchor Region and Influenza Hemagglutinin (HA1) Retains Its Binding Activity. Symposium of the Malaysian Society for Microbiology, Promenade Hotel Sabah, 12 - 15 Dec 2012 (Oral Presentation) 47 Ong GH, Chang LY, Vadivelu J. Isolation and characterisation of environmental phages of Burkholderia pseudomallei. The 17th Biological Sciences Graduate Congress 2012, 8-10 December, 2012, Bangkok, Thailand. The 17th Biological Sciences Graduate Congress Program and Abstracts. Abstract no CMB-PO24; pp 196 48 Farid S, Fatemeh Molaei V, Maysam O, Rusdi AR, Mohamad Hussain H, Fatimah I. ( 2012). Electro Acupuncture (EA) as an adjunct therapy to methadone maintenance treatment (MMT) in heroin addiction : A study of 2D EEG power spectral topography and morlet wavelet. Proceedings of the IEEE-EMBS International Conference on Engineering & Sciences, 1719 December 2012, Langkawi, Malaysia. Abstract no 1569659175 ;pp. 80-81 (ISI-Cited Publication). 49 T.Zaman, A.A.Abbas, A.Suhaeb, S.Naveen. The effects of Hyaluronic Acid and Allogenic Bone Marrow derived-Mesenchymal stem cells in delaying osteoarthritic progression of the knee: A preliminary study. International Cartilage Research Soceity (ICRS). 10th World Congress Meeting. May 12-15th 2012, Montreal – Canada. Poster No. 208. 50 Tan, C.S., Ng, S.T., Yeannie Yap, H.Y., Lee,S.S., Lee, M.L., Fung, S.Y., Tan, N.H., Tay, S.T. and Sim, S.M. (2012). Breathing new life to a Malaysian lost national treasure – the Tiger Milk Mushroom (L. rhinocerus). Paper presented at the 18th Congress of the International Society of Mushroom Science, Aug 16th -30th, 2012. Beijing, China 51 Ng, S.T., Tan, C.S., Yeannie Yap, H.Y., Fung, S.Y., Tan, N.H. (2012). Molecular phylogeny of L. rhinoceros (Tiger Milk Mushroom) based on complete 18S and 28S ribosomal DNA sequences. Paper presented at the 18th Congress of the International Society of Mushroom Science, Aug 16th -30th, 2012. Beijing, China. 52 Lee, M.L., Tan, N.H., Fung, S.Y., Ng, S.T., and Tan, C.S. (2012). Anti-proliferative activity of tiger milk mushroom (L. rhinoceros) and gene expression alterations of MCF-7 breast cancer cells induced by treatment with the mushroom extract. Paper presented at the 18th Congress of the International Society of Mushroom Science, Aug 16th -30th, 2012. Beijing, China 53 Yeannie Yap, H.Y., Tan, N.H., Fung, S.Y., Azlina, A.A., Ng, S.T. and Tan, C.S. (2012). Evaluation of antioxidant activity of Lignosus rhinoceros (tiger milk mushroom) sclerotia. Paper presented at the 18th Congress of the International Society of Mushroom Science, Aug 16th -30th, 2012. Beijing, China 54 Umar Y Mohammed, Awang M Bulgiba, Zamri B chik, Christopher Lee, Devi Peramalah (2012). Factors affecting adherence level to HAART (Adherence predictors) in a major hospital in Kuala Lumpur, Malaysia. 1st Asia Pacific Clinical Epidemiology and Evidence Based Medicine Conference (APCEEBM), Kuala Lumpur-Malaysia 55 Umar Y Mohammed, Awang M Bulgiba, Zamri B chik, Christopher Lee, Devi Peramalah (2012). Is Therapeutic Drug Monitoring (TDM) the best method for measuring adherence level to HAART in HIV positive patients in Kuala Lumpur Malaysia? Oral presentation in APACPH 2012 in Colombo Seri-lanka 56 Awang M Bulgiba, Umar Y Mohammed, Zamri B chik, Christopher Lee, Devi Peramalah (2012). How well does self-reported adherence fare in relation to therapeutic drug monitoring in HAART?.1st Asia Pacific Clinical Epidemiology and Evidence Based Medicine Conference (APCEEBM), Kuala Lumpur-Malaysia 57 Al-Maleki, A. R., Mariappan, V., Vellasamy, K. M., Kalaiselvam, K., Loke, M. F., Tay, S. T., Vadivelu J. Comparative proteomic analysis of colony morphology variants of Burkholderia pseudomallei pre- and post-exposure to human lung epithelial cells (A549). The 17th Biological Sciences Graduate Congress 2012, 8-10 December, 2012, Bangkok, Thailand. The 17th Biological Sciences Graduate Congress Program and Abstracts. Abstract no BT-PO11; pp147 58 Shani Samuel, Sangeetha Naveen and T. Kamarul. Growth Factor Quantification and 59 60 High Impact Research Annual Report 2012 The Cellular Induced Proliferation Potential of Activated and Non-Activated Platelet Rich Plasma on Human Mesencymal Stem Cells. 42nd Malaysian Orthopaedic Association, Annual General Meeting /Annual Scientific Meeting, 14 to 17 June 2012, Sultan Ahmad Shah International Convention Centre, Kuantan, Pahang. 59 Tan JAMA. Updates of prenatal diagnosis of thalassaemia in Malaysia. 2012. Malaysian Society of Haematology Mini Summit, Malacca, Malaysia. 60 Chen JJ, Chua KH, Tan PC, George E, Tan JAMA. 2012. Non-invasive prenatal diagnosis using informative CpG sites: A possibility for confirmation of β-thalassaemia mutations in foetal DNA. 10th Asia Pacific Conference on Human Genetics, Kuala Lumpur, Malaysia 61 Kho SL, Chua KH, George E, Tan JAMA. 2012. Specific molecular characterisation of β-globin gene mutations using Quantitative Real-time PCR: A rapid and effective molecular screening technique for thalassaemia in Malaysia. 10th Asia Pacific Conference on Human Genetics, Kuala Lumpur, Malaysia 62 M.S. Kanthimathi, J. Rajarajeswaran. 2012. Dietary spices inhibit cancer cell migration and protect against DNA damage.16th Biennial Meeting of the Society for Free Radical Research International, Imperial College, London. S83 63 Jayakumar Rajarajeswaran and M.S.Kanthimathi (2012) Anticancer activity and inhibition of cancer cell migration of spice essential oils.37th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, Sime Darby Convention Centre, Kuala Lumpur: 78 64 Esther Tang Lai Har, R.Jayakumar, Fung Shin Yee and M.S.Kanthimathi (2012) Coriandrum sativum and Petroselinum crispum inhibit cancer cell migration and protect against hydrogen peroxide-induced DNA damage.37th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, Sime Darby Convention Centre, Kuala Lumpur: 69 65 Hookworm Navigator- Rapid detection assay for human hookworm species (2012). BioMalaysia 2012, KLCC, Kuala Lumpur 66 Kuppusamy, U.R., Ng, Z. X., Chua, K.H., Richardson, J.S., Abdul Malek, S.N. (2012, November). Use of customized cooking methods to improve antioxidant & nutritional values of selected vegetables. Abstract presented at The 4th International Conference on Natural Products for Health & Beauty (NATPRO4), Chiang Mai University, Thailand 67 Sarasvathy, S., Vikineswary, S. Tan, W.C, Kuppusamy, U.R. (2012, November). Study of antioxidant activity of fresh fruiting bodies of Ganoderma neo-japonicum extracts. Abstract presented at The 4th International Conference on Natural Products for Health & Beauty (NATPRO4), Chiang Mai University, Thailand 68 Arumugam, B., Manaharan, B., Chua, K.H., Palanisamy, U.D., Kuppusamy, U.R. (2012, November). Antioxidant properties of Syzygium aqueum and its protective role against hydrogen peroxide-induced oxidative stress in 3T3-L1 preadipocytes. Abstract presented at The 4th International Conference on Natural Products for Health & Beauty (NATPRO4), Chiang Mai University, Thailand 69 Tan, X.C., Chua, K.H., Kuppusamy, U.R. (2012, December). Prolonged oxidative stress stimulates differentiation and lipogenesis in 3T3L1 adipocytes. Abstract presented at The 17th Biological Sciences Graduate Congress (17TH BSGC), Chulalongkorn University, Thailand 70 Baskaran, A., Vikineswary, S. Kuppusamy, U.R. (2012, December). Inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage by extracts of selected medicinal mushrooms. Abstract presented at The 17th Biological Sciences Graduate Congress (17TH BSGC), Chulalongkorn University, Thailand 71 Hashim OH. Writing and Publishing of Manuscripts. Publish or Perish Seminar, Advance Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, 18th June, 2012. 72 Hashim OH. Selective past proteomics studies at UMCPR. UMCPR Research Day and Proteomics Workshop, Faculty of Medicine, University of Malaya, 21st June, 2012. 73 Hashim OH. Champedak lectins: From the humble seed to targeted proteomics. 37th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, 18-19 July 2012, Sime Darby Convention Centre, Kuala Lumpur. Abstract no Plenary 1; pp 22. 74 Hashim OH. Selective past proteomics studies at UMCPR. Australian Proteome Analysis Facility (APAF) – UMCPR Meeting, Faculty of Medicine, University of Malaya, 24th Sept, 2012. 75 Hashim OH. Selective past proteomics studies at UMCPR. Australian Proteome Analysis Facility (APAF) – UMCPR Meeting, Faculty of Medicine, University of Malaya, 24th September, 2012. 76 Chong URW, Abdul-Rahman PS, Abdul-Aziz A, Hashim OH, Mat-Junit S. Tamarindus indica fruit pulp extract alters the secretion of lipidassociated proteins from HEP2 cells. 37th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, 18-19 July 2012, Sime Darby Convention Centre, Kuala Lumpur. Abstract no P10; pp 65. 77 Razali N, Abdul-Aziz A, Mat-Junit S. Gene expression profiles in human HEP2 cells treated with methanol extract of the Tamarindus indica seeds. 37th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, 18-19 July 2012, Sime Darby Convention Centre, Kuala Lumpur. Abstract no P45; pp 99. 78 Kong KW, Mat-Junit S, Aminudin N, Ismail A, Abdul-Aziz A. Protective effects of water extracts from Barringtonia racemosa shoots towards in vitro oxidation of human serum, low density lipoprotein and haemoglobin. 37th Annual Conference of the Malaysian Society for High Impact Research Annual Report 2012 Biochemistry and Molecular Biology, 18-19 July 2012, Sime Darby Convention Centre, Kuala Lumpur. Abstract no P87; pp 141. Hospital, Mahidol University, Department of Medical Sciences, Ministry of public Health,and RIKEN, Japan, (International) 79 Juvarajah T, Hashim OH, Fung SY, AbdulRahman PS. Proteomic profiling of milk fat globule membrane proteins of ruminants and humans. 1st Malaysian Proteomics Conference, 26-27 September 2012, Eastin Hotel, Penang. Abstract no O23; pp 38. 88 NorAmdan, N. A. & AbuBakar, S. (2012, November). Cloning, expression and purification of Burkholderia pseudomallei antigenic protein. Paper presented at the International Conference on Clinical Microbiology & Microbial Genomics, San Antonio, Texas 80 Determinants of unsuccessful tuberculosis treatment outcome in Malaysian HIV-infected patients. Proceeding of the 1st Asia Pacific Clinical Epidemiology and Evidence Based Medicine Conference, 6-8 July 2012, Kuala Lumpur. 89 Central adiposity and body composition as indicators of dyslipidaemia among adolescents in Kuala Lumpur: A case-control study, 26th Scientific Meeting of Malaysian Society of Pharmacology & Physiology, 18 May 2012 to 20 May 2012, Malaysian Society of Pharmacology and Physiology, (National) 81 Predictors of survival in TB/HIV co-infected patients in Klang Valley. Proceeding of the 2nd International Public Health Conference & 19th National Public Health Colloquium Conference , 3-4 October 2012, Kuala Lumpur 82 Zaki, R., Bulgiba, A., & Ismail, N. A. Overestimation bias. 1st Asia Pacific Clinical Epidemiology & Evidence Based Medicine (APCEEBM) Conference, Kuala Lumpur. 6 – 8 July 2012. Oral presentation 83 Kamarul, T; Kamisan, B N; Ahmad, R E; Naveen, S. Cartilage of different mammalian species demonstrate variable tissue thickness, cell density, proteoglycan content and cartilage specific genes. 42nd Malaysian Orthopaedic Association, Annual General Meeting /Annual Scientific Meeting, 14 to 17 June 2012, Sultan Ahmad Shah International Convention Centre, Kuantan, Pahang. Oral Presentation for Mahmood Merican Award. 84 HY Nam, B Pingguan-Murphy, AA Abbas, AM Merican, T Kamarul. A Preliminary Report on the Behaviour of Human Bone Marrow DerivedMesenchymal Stem Cells during Uniaxial Cyclic Loading. 42nd Malaysian Orthopaedic Association, Annual General Meeting /Annual Scientific Meeting, 14 to 17 June 2012, Sultan Ahmad Shah International Convention Centre, Kuantan, Pahang. 85 Kamarul, T; Kamisan, B N; Ahmad, R E; Naveen, S. Cartilage of different mammalian species demonstrate variable tissue thickness, cell density, proteoglycan content and cartilage specific genes. 42nd Malaysian Orthopaedic Association, Annual General Meeting /Annual Scientific Meeting, 14 to 17 June 2012, Sultan Ahmad Shah International Convention Centre, Kuantan, Pahang. Oral Presentation for Mahmood Merican Award. 86 Predictors of Survival in Malaysian HIV infected patients on anti-retroviral therapy. APCEBM conference in 2012, oral presentation 87 Pharmacogenomics Studies in Multiethnic Malaysians, Symposium for Genetic and Genome Guided Personalized Medicine in Asia: Overview and Applications, 02 Feb 2012 to 03 Feb 2012. Bangkok, Thailand. Thailand Center of Excellence for Life Sciences (Public Organization) together with Faculty of Medicine, Ramathibodi 90 Chin Y, Lim SH, Kiew LV, Chung LY, Lee HB, Zorlu Yunus, Ahsen V, Dumoulin F. Improved efficacy of modified Zinc(II) phthalocyanines as photosensitizers for phtodynamic therapy. 26th Scientific Meeting of Malaysian Society of Pharmacology & Physiology (MSPP2012), 18-20 May 2012, Equatorial Hotel, Penang. Abstract No. P015; pp. 92. 91 Lim SH, Wu L, Kiew LV, Burgess K, Chung LY, Lee HB. Rosamines target the cancer oxidative phosphorylation pathway: In vitro and in vivo. 26th Scientific Meeting of Malaysian Society of Pharmacology & Physiology (MSPP2012), 18-20 May 2012, Equatorial Hotel, Penang. Abstract No. P016; pp.92. 92 Chin Y, Kiew LV, Chung LY, Zorlu Y, Ahsen V, Dumoulin F, Lee HB, Lim SH. Glycerol substituted Zn(II)-phthalocyanines as photosensitizers for PDT treatment of cancer. 9th International Symposium on Photodynamic Therapy and Photodiagnosis in Clinical Practice, and 4th International Meeting of the European Platform for Phtodynamic Medicine (EPPM), 1620 October 2012, South Tyrol, Italy. Abstract No./ Poster No. 54; pp. 59. FACULTY OF ENGINEERING 1 Hayyan M., Mjalli F.S., Hashim M. A., Hayyan A., AlNashef I. M., Purification of Palm Oil-Based Fatty Acid Methyl Ester Using Deep Eutectic Solvents, 102nd American Oil Society (AOCS) Annual Meeting and Expo, Cincinnati, Ohaio, USA, 2011. 2 Hayyan A., Hashim M. A, Mjalli F.S. , Hayyan M.,, AlNashef I. M., Reduction of Free Fatty Acids in Crude Palm Oil Via Trifluoromethanesulfonic Acid, 102nd American Oil Society (AOCS)Annual Meeting and Expo, Cincinnati, Ohaio, USA, 2011. 3 Hayyan M., Mjalli F.S., Hashim M. A., Hayyan A., AlNashef I. M.,Electrochemical generation of Superoxide Ion-Radical in 1-Hexy-1-Methy1Pyrrolidinum bis (Tryfluoromethylsulfunnyl), 2nd International Conference on Biotechnology Engineering (ICBioE’11), International Islamic University Malaysia, Kuala Lumpur, Malaysia, 2011. 61 62 High Impact Research Annual Report 2012 4 Hayyan M., Mjalli F. S., Hashim M. A., AlNashef I. M., Investigating The Stability of Superoxide Ion-Radical in Bis (Trifluoromethylsulfonyl) ImideBased Ionic Liquids, International congress on Green Process Engineering (GPE2011), Kuala Lumpur, Malaysia, 2011. 14 Abnisa F, Wan Daud WMA, Sahu JN. Pyrolysis of palm shell and polystyrene mixtures: an optional technique to obtain the high-grade of pyrolytic liquid. Proceedings of the Fourth International Symposiumon Energy From Biomass And Waste, Venice, Italy, November 12-15, 2011. 5 Hayyan M., Mjalli F. S., Hashim M. A., AlNashef I. M., Utilizing of Tris(pentafluoroethyl) trifluorophosphate Anion Based-Ionic Liquids as Media for Generation of Superoxide Ion, The Fourth International Chemistry Conference, Riyadh- Kingdom of Saudi Arabia, 2011. 6 Liaquat AM, Masjuki HH, Kalam MA, Varman M, Hazrat, MA, Shahabuddin M, Mofijur M. Application of blend fuels in a diesel engine. 2nd International Conference on Advances in Energy Engineering (ICAEE 2011), 27-28 December 2011,Bangkok, Thailand. 15 Helen-Ng LC, Razak IA, Ghani WMN, Marhazlinda J, Norlida A, Zain RB. Dietary consumption pattern and risk of oral cancer – a Malaysia scenario. 3rd World Congress of the International Academy of Oral Oncology, Yin and Yang: Balancing Cure and Consequences, 14-17 July 2011, Grand Copthorne Waterfront Hotel, Singapore. Oral Oncology Abstract no P98; pp 105. 7 Liaquat AM, Masjuki HH, Kalam MA, Varman M. Friction and wear characteristic of waste vegetable oil contaiminated lubricants. Regional Tribology Conference (RTC 2011), 22-24 November 2011, Bayview Hotel, Langkawi, Malaysia. 16 Helen-Ng LC, Razak IA, Ghani WMN, Marhazlinda J, Norlida A, Zain RB. Dietary consumption pattern and risk of oral cancer – a Malaysia scenario. 3rd World Congress of the International Academy of Oral Oncology, Yin and Yang: Balancing Cure and Consequences, 14-17 July 2011, Grand Copthorne Waterfront Hotel, Singapore. Oral Oncology Abstract no P98; pp 105. 8 Liaquat AM, Masjuki HH, Kalam MA, Varman, M, Hazrat MA. Experimental analysis on engine performance and emission characteristics using biodiesel obtained from non-edible oil. Regional Conference on Automotive Research (ReCAR 2011), 14-15 December 2011, Kuala Lumpur, Malaysia. 17 A. Mahmoudi, N. A. Rahim, W. P. Hew, “A Comparison between the TORUS and AFIR Axial-Flux Permanent-Magnet Machine Using Finite Element Analysis” IEEE International Electric Machine and Drives Conference (IEMDC), Nigara Fall, Canada, 15th - 18th May, 2011. 9 Mofijur M, Masjuki HH, Kalam MA, Shahabuddin M, Hazrat MA, Liaquat AM. Palm oil methyl ester and its emulsions effect on lubricant performance and engine components wear. 2nd International Conference on Advances in Energy Engineering (ICAEE 2011), 27-28 December 2011, Bangkok,Thailand. 18 M. A. Hashim, A. Hayyan, F. S. Mjalli, Y. M. Al-Wahaibi, T. Al-Wahaibi, M. Hayyan, I. M. AlNashef Biodiesel Production from Acidic Crude Palm Oil using Two-Step Processes International conference in Energy Development Research, Kuwait, April 2012. 10 Shahabuddin M, Masjuki HH, Kalam MA, Mofijur M, Hazrat MA, Liaquat AM. Effect of additive on performance of C.I. engine fuelled with bio diesel. 2nd International Conference on Advances in Energy Engineering (ICAEE 2011), 27-28 December 2011, Bangkok, Thailand. 11 Shahbaz K., Mjalli F. S., Hashim M. A., Al Nashef I. M., Elimination of free glycerol from palm oilbased biodiesel using phosphonium-based ionic liquids analogues, 3rd International Congress on Green Process Engineering (GPE 2011), Kuala Lumpur, Malaysia, 2011. 12 Moo, E.K., Abu Osman, N.A., Pingguan-Murphy, B., Han, S. K., Federico, S., Herzog, W.(2011). Mechanical Behavior of in-situ Chondrocyte at Different Loading Rates: A Finite Element Study. Biomed2011, IFMBE Proceedings 35, 182-186. (Kuala Lumpur, Malaysia, June 20th - 23rd, 2011) 13 Moo, E. K., Herzog, W., Han, S. K., Abu Osman, N. A., Pingguan-Murphy, B., Federico, S. In-situ Chondrocyte Mechanics at Different Loading Rates: A Finite Element Study. Proceedings of the12th Annual Alberta Biomedical Engineering Conference, 29. (Banff, Canada, October 21st23rd, 2011) 19 Mukhtar A. Kareem, Farouq S. Mjalli, Mohd. Ali Hashim, Inas M. AlNashef, Fatemeh Saadat Ghareh Bagh. Reducing energy consumption in ethylene production by green solvents utilization. International Conference on Environmental Research and Technology 2012, Penang, Malaysia 20 Mukhtar A. Kareem, Farouq S. Mjalli, Mohd. Ali Hashim, Inas M. AlNashef, Fatemeh Saadat Ghareh Bagh. Application of deep eutectic solvents based on ethylene glycol and sulfolane for the extraction of toluene from toluene/ heptane mixtures. International Conference on Process Engineering and Advanced Materials 2012, Kuala Lumpur, Malaysia 21 Kaveh shahbaz, Saeid Baroutian, Farouq S. Mjalli, Mohd Ali Hashim, Inas M. AlNashef. Artificial Intelligent Techniques for Modeling the Glycerol Removal from Biodiesel using Ammonium and Phosphunium Based Deep Eutectic Solvents. International Conference on Global Sustainability and Chemical Engineering (ICGSCE 2012), Shah Alma, Malaysia, 2012. 22 Kaveh shahbaz, Farouq S. Mjalli, Mohd Ali Hashim, Inas M. AlNashef.Purification of palm oil-based biodiesel using deep eutectic solvents. High Impact Research Annual Report 2012 University of Malaya Researcher’s Conference (UMRC 2012), Kuala Lumpur, Malaysia, 2012 23 M. Karimi,H. Mokhlis, A.H.A Bakar, A. Shahriari, M.A. Faradonbeh, H.M. Rosli,”Impact of load modeling in distribution state estimation”,6th International Power Engineering and Optimization Conference (PEOCO2012),pp.67- 71, 6-7 June 2012 doi: 10.1109/PEOCO.2012.6230837 24 M. Karimi,H. Mokhlis, A.H.A Bakar, A. Shahriari, M.A. Faradonbeh, H.M. Rosli,”Impact of load modeling in distribution state estimation”,6th International Power Engineering and Optimization Conference (PEOCO2012),pp.67- 71, 6-7 June 2012 doi: 10.1109/PEOCO.2012.6230837 25 M. Karimi, H.Mokhlis, A.H.A. Bakar, J.A. Laghari, A. Shahriari,M.M. Aman,”Combination of adaptive and intelligent load shedding techniques for distribution network”,6th International Power Engineering and Optimization Conference (PEOCO2012),pp.57-61, 6-7 June 2012 doi:10.1109/PEOCO.2012.6230835 26 RAMIN HOSSEINI KUPAEI, U.JOHNSON ALENGARAM , MOHD ZAMIN BIN JUMMAT. A REVIEW ON FLY ASH-BASED GEOPOLYMER CONCRETE. 11th International Conference on Concrete Engineering and Technology 2012 (CONCET2012).11th –14th June 2012, Putrajaya, Malaysia, pp 174-180. 27 B.A. AL MUHIT, U.J. ALENGARAM, MOHD. Z. JUMAAT, K.Y.FOONG. GEOPOLYMER CONCRETE: A BUILDING MATERIAL FOR THE FUTURE. 11th International Conference on Concrete Engineering and Technology 2012 (CONCET2012).11th –14th June 2012, Putrajaya, Malaysia, pp 102-107. 28 U. JOHNSON ALENGARAM and B.A.AL. MUHIT. Mechanical Properties of Oil Palm Shell Foamed Concrete: A Micro-structural Approach Using SEM. Research, Development, and Practice in Structural Engineering and Construction. Vimonsatit, V., Singh, A., Yazdani, S. (eds.). ASEA-SEC-1, Perth, November 28–Decmber 2, 2012 29 T. Ariga, Y. Miyazawa, M. Hamdi, M. Sekine, K. Kanda. Attached Effect of Porous Metal in a Brazed Joint. IBSC 2012: Proceedings from the 5th International Brazing and Soldering Conference, April 22–25, 2012, Las Vegas, Nevada, USA. 30 H. Nashrah, Y. Farazila, M. Hamdi. Effect of Adding Porous Cu on the Microstructure and Mechanical Properties of Pb-Free Solder Joint. 35th International Electronic Manufacturing Technology Conference, November 6-8, 2012, Kinta River Front Hotel, Ipoh, Perak, Malaysia. 31 Liaquat AM, Masjuki HH, Kalam MA, Bhuiya MMK, Varman M. Influence of coconut biodiesel and waste cooking oil blended fuels on engine performance and emission characteristics. Proceedings of the 2012 Fall Conference of the ASME Internal Combustion Engine Division (ICEF2012), 23-26 September 2012, Vancouver, BC, Canada. 32 Liaquat AM, Masjuki HH, Kalam MA, Varman M. Impact of biodiesel on injector deposit formation. 5th AUN/SEED-Net Regional Conference on New/Renewable Energy 26-27 September 2012, School of Transportation Engineering, Hanoi University of Science and Technology. 33 Liaquat AM, Masjuki HH, Kalam MA, Varman M. Engine performance and exhaust emissions of a single cylinder CI engine fuelled with coconut biodiesel blended fuels. 5th AUN/SEED-Net Regional Conference on New/Renewable Energy 26-27 September 2012, School of Transportation Engineering, Hanoi University of Science and Technology. 34 Shahabuddin M, Masjuki HH, Kalam MA, Zulkifli NWM, Nazira V, Mofijur M. Biofuel: potential energy source in road transportation sector in Malaysia. International Conference on Sustainable Future Energy 2012 and 10th SEE FORUM Innovations for Sustainable and Secure Energy, 21-23 November 2012, Brunei Darussalam. 35 Liaquat AM, Masjuki HH, Kalam MA, Rizwanul Fattah IM, Hazrat MA, Varman M, Mofijur M, Shahabuddin M. Effect of coconut biodiesel blended fuels on engine performance and emission characteristics. 5th BSME International Conference on Thermal Engineering, 21-23 December 2012, Dhaka, Bangladesh. 36 Shahabuddin M, Masjuki HH, Kalam MA. Experimental investigation into tribological characteristics of bio-lubricant formulated from Jatropha oil. 5th BSME International Conference on Thermal Engineering, 21-23 December 2012, Dhaka, Bangladesh. 37 Chai AB, Andriyana A, Verron E, Johan MR. A pseudo-elastic model for the Mullins effect in swollen rubber. 4th International Conference on Solid State Science and Technology (ICSSST). 18-20 December 2012. Malacca, Malaysia. 38 Loo MS, Andriyana A, Verron E, Chagnon G, Afifi AM. Mullins effect in swollen rubber under cyclic loading. International Conference on Automotive and Materials Engineering (ICAME’2012). 27-28 November 2012. Penang, Malaysia 39 Chai AB, Andriyana A, Verron E, Johan MR. Diffusion of biodiesel in rubber and the resulting mechanical response under cyclic loading. Proceedings of 8th International Conference on Diffusion in Solids and Liquids (DSL). 25-29 June 2012. Turkey, Istanbul. 40 Ch’ng SY, Andriyana A, Verron E, Ahmad R. Diffusion of palm biodiesel in elastomers undergoing multiaxial large deformations. Proceedings of 8th International Conference on Diffusion in Solids and Liquids (DSL). 25-29 June 2012. Turkey, Istanbul. 41 Ch’ng SY, Andriyana A, Verron E, Ahmad R. Asian International Conference on Materials, Minerals, and Polymer 2012 (MAMIP2012). 23-24 March, 2012. Penang, Malaysia. 42 M. Hamdi, Y. Farazila, M. Fadzil, T. Zaharinie, T. Ariga. The International Conference on Integrated 63 64 High Impact Research Annual Report 2012 Systems, Design and Technology, May 12-15, 2012, Mallorca, Spain. 43 Y. Farazila. A Feasibility Study on the Friction Stir Welding (FSW) of Ultra-Thin Sheet Aluminium Alloy. 3rd UKM-NUT Joint Seminar, October 13, 2012, Puri Pujangga, Universiti Kebangsaan Malaysia, Bangi, Selangor. 44 Moo, E. K., Federico, S., Han, S. K., Abu Osman, N. A., Pingguan-Murphy, B, Herzog, W. Articular Chondrocyte Mechanics at Different Loading Rates. Proceedings of the17th Biennial Meeting of the Canadian Society of Biomechanics (Vancouver, Canada, June 6 th-9th, 2012 ) 45 Moo, E. K. , Han, S. K., Jinha, A., Abusara, Z., Abu Osman, N.A., Pingguan-Murphy, B., Herzog, W. Boundary Conditions Affect Mechanical Behaviour of in-situ Chondrocytes. 36 th Annual Meeting of the American Society of Biomechanics (Gainesville, Florida, United States, August 15th-18th, 2012) 46 Moo, E. K., Amrein, M., Abu Osman, N. A., Pingguan-Murphy, B., Herzog, W. Chondrocyte Membrane Mechanics at Different Loading Rates. Proceedings of the13th Annual Alberta Biomedical Engineering Conference, 103. (Banff, Canada, October 19th-21st, 2012) 47 Nor Elleeiana Mohd Syah, Nur Azah Hamzaid, Noor Azuan Abu Osman, Chung Tze Yang (2012). Gait Characterization across Different Profile of Prosthesis and Orthosis User’s: Towards Developing A New Smart Prosthetic Leg. 2012 World Congress on Medical Physics and Biomedical Engineering (WC2012). Beijing, China, May 26-31, 2012. 48 Y. Farazila. Utilizing friction spot joining for dissimilar joint of aluminum alloy (A5052) and polyethylene terephthalate (PET). JWRI-UM seminar 2012, November 21, 2012, JWRI, Osaka University. 49 M. M. Hasan, A. Mahrous, S. Mekhilef “Analyses and Simulation of Three-phase MLI with High Value of Resolution per Switch employing SVM control scheme” 2012 IEEE International Power and Energy Conference (PECON 2012),Sabah, Malaysia, 2 - 5 Dec 2012 50 M. M. Hasan, A. Mahrous, S. Mekhilef “Simulation and Analyses of 3-Phase 27-Level Inverter using SVM Control Scheme” Fifteenth International Middle East Power Systems Conference MEPCON’12 Alexandria, Egypt, December, 23-25, 2012 51 S. Mekhilef, H.I. Khudhur, H. Belkamel, DC link capacitor voltage balancing in three level neutral point clamped inverter, Control and Modeling for Power Electronics (COMPEL), 2012 IEEE 13th Workshop on, 2012, pp. 1-4 52 N.M. Karim, S. Manzoor, N. Soin, S.F. Yew, M. Mounir. Prediction of energy change due to hot carrier injection. Presented in MNE 2012. 53 S. P. YAP, K.Y. FOONG, U. J. ALENGARAM & M. Z. JUMAAT. WASTE MATERIALS IN MALAYSIA FOR THE DEVELOPMENT OF SUSTAINABLE CONCRETE: A REVIEW. 11th International Conference on Concrete Engineering and Technology 2012 (CONCET2012).11th –14th June 2012, Putrajaya, Malaysia, pp 113-118. 54 S. Kahourzade, A. Mahmoudi, N. A. Rahim, and H. W. Ping “Sizing Equation and Finite Element Analysis Optimum Design of AxialFlux Permanent-Magnet Motor for Electric Vehicle Direct Drive” IEEE International Power Engineering and Optimization Conference, Melaka, Malaysia 2012, 6th - 7th June 2012. 55 Chong,H.Y., Dahari,M., Yap,H.J., Loong, Y.T. Development of Hazard Assessment for Hydrogen Refueling Station in Malaysia. 3rd International Conference on Mechanical and Manufacturing Engineering 2012, University Tun Hussein Onn Malaysia (UTHM), Malaysia. 56 N.M. Karim, S. Manzoor, N. Soin. Statistical forecasting algorithm on circuit level gain transformation due to negative bias temperature instability under microwave frequency spectrum. Presented in Nanosmat 2012. 57 Y.Abdul Wahab, A.F. Ahmad, H. Hussin, S. Shahabuddin, N. Soin. 2012. Integrated Diffuser Process Optimizations on Defect Metrology Performance. 38th International Micro & Nano Engineering Conference (MNE 2012). Presented 58 Y.Abdul Wahab, A.F. Ahmad, H. Hussin, N. Soin. 2012. Reduction of Annealed Induced Wafer Defects in Dual-Damascene Copper Interconnects. 23rd European Symposium on Reliability of Electron Devices, SeptemberOctober 2012, Presented. 59 N. Soin, S. Shahabuddin, K.K. Goh, Y. Abdul Wahab, H. Hussin, Experimental Degradation Analysis in Lateral DMOS Transistors. MNE 2012. Presented. 60 N. Soin, S.S. Shahabuddin, K.K. Goh, Measurement and Characterization of Hot Carrier Safe Operating Area (HCI-SOA) in 24V n-type Lateral DMOS Transistors. ICSE 2012. Presented. 61 M.H. Kamaruddin, N. Soin. Application of Three-terminal Charge Pumping Measurement in trench-gate DMOS Fowler-Nordheim tunnelling stress. MNE 2012. (Presented) 62 T. Zaharinie, Y. Farazila, M. Hamdi, T. Ariga. A Study on Interfacial Reaction and Titanium Distribution in Brazing Sapphire to Inconel 600 Using Cu/Ni Porous Composite. IBSC 2012: Proceedings from the 5th International Brazing and Soldering Conference, April 22–25, 2012, Las Vegas, Nevada, USA. 63 B. Rismanchi, R. Saidur, H.H. Masjuki, T.M.I. Mahlia, Cost-benefit analysis of using cold thermal energy storage systems in building applications, 2012, pp. 493-8. 64 Chong WT, Poh SC, Fazlizan A, Yip SY, Koay MH and Hew WP. Exhaust air energy recovery system for electrical power generation in future green cities. International Symposium on Green Manufacturing and Applications (ISGMA 2012). May 2012, Jeju, Korea. 65 Chong WT, Poh SC, Fazlizan A, Yip SY and Hew WP. The design and testing of an exhaust air High Impact Research Annual Report 2012 energy recovery wind turbine generator. World Renewable Energy Froum (WREF 2012), May 2012, Denver, US. 66 Chong WT, Fazlizan A, Poh SC, Pan KC, and Hew WP. The design, simulation and testing of an urban vertical axis wind turbine with the omnidirection-guide-vane. International Conference on Applied Energy, (ICAE 2012), Jul 5-8, 2012, Suzhou, China 67 A. Saghafinia, S. Kahourzade, A. Mahmoudi, W. P. Hew, M. Nasir Uddin, “On Line Trained Fuzzy Logic and Adaptive Continuous Wavelet Transform Based High Precision Fault Detection of IM with Broken Rotor Bars” 47th IEEE IAS Annual Meeting, Las Vegas, NV, USA, 7th – 11th October 2012. 68 Loong, Y.T., Dahari,M., Yap,H.J.,Chong,H.Y. Modeling and Simulation of Solar Powered Hydrogen System. 3rd International Conference on Mechanical and Manufacturing Engineering 2012, University Tun Hussein Onn Malaysia (UTHM), Malaysia. FACULTY OF SCIENCE 1 Abdelahhad Barbour, Koshy Philip and Sekaran Muniandy (2011). Production of Lantibiotic Salivaricin by Streptococcus salivarius isolated from Malaysian subjects and its antimicrobial activity. International Congress of the Malaysian Society for Microbiology 2011 2 Abdul-Muhsin M Shami, Koshy Philip and Sekaran Muniandy (2011). Antibacterial effect, antioxidant potential and content of Phenolic compounds in aqeous and ethanolic extracts of plant mixture against selected microorganisms. International Congress of the Malaysian Society for Microbiology 2011 3 Crystal Engineering: Steric Bulk as a Design Element - Implications for Luminescence and Nanoparticle Generation, Departmental Seminar, 26 Apr 2011 to 26 Apr 2011, Department of Chemistry, (University) 4 Emerging supramolecular synthons: Stabilisation of crystal structures by C H.pi(chelate ring) and by metal(lone pair).pi(aryl) interactions, Chemistry Departmental seminar, 13 Oct 2011 to 13 Oct 2011, Department of Chemistry, (University) 5 Emerging supramolecular synthons: Stabilisation of crystal structures by C H...pi(chelate ring) and by metal(lone pair)...pi(aryl) interactions, 3rd Asian Conference on Coordination Chemistry (ACCC-3), 17 Oct 2011 to 17 Oct 2011, Asian Coordination Chemistry Committee, (International) 6 7 Foo Yoke Wai, Koshy Philip and Sekaran Muniandy (2011). Isolation and Identification of Lactobacillus with Antimicrobial Properties from a Food Supplement. International Congress of the Malaysian Society for Microbiology 2011 (Best Poster Award) Goh Hweh Fen, Koshy Philip (2011). Isolation and Identification of Lactic Acid Bacteria with Antimicrobial Properties from Fermented Food Products. International Congress of the Malaysian Society for Microbiology 2011. 8 Helen-Ng LC, Razak IA, Ghani WMN, Marhazlinda J, Norlida A, Zain RB. Dietary consumption pattern and risk of oral cancer – a Malaysia scenario. 3rd World Congress of the International Academy of Oral Oncology, Yin and Yang: Balancing Cure and Consequences, 14-17 July 2011, Grand Copthorne Waterfront Hotel, Singapore. Oral Oncology Abstract no P98; pp 105. 9 Metal-thiolates: Novel Pharmaceutical Potential of Gold and Bismuth against cancer, arthritis and viral disease, Chemistry Department Seminar, 16 Nov 2011 to 16 Nov 2011, Department of Chemistry, (University) 10 Nanogold and gold compounds pharmaceutical applications, Bali International Seminar on Science and Technology (BISSTECH 2011), 22 Jul 2011 to 23 Jul 2011, Prof. Putra Manuaba (Udayana University), (International) 11 Bismuth: Non-toxic Compounds with Huge Pharmaceutical Potential, Departmental Seminar, 17 Apr 2012 to 17 Apr 2012, Department of Chemistry, (University) 12 Dazylah Darji and Yatimah Alias. Dissolution of rubber biomass in ionic liquids. 17th Malaysian Chemical Congress (17MCC) 2012, 15-17th Oct 2012, Putra World Trade Centre, Kuala Lumpur. Poster. 13 Kumuthini Chandrasekaram, Sharifah Mohamad, Hemavathy Surikumaran, Muggundha Raoov, Tilagam Marimuthu and Puvaneswary Subramaniam. Dicationic ionic liquid inclusion with β-Cyclodextrin. 17th Malaysian Chemical Congress (17MCC) 2012, 15-17th Oct 2012, Putra World Trade Centre, Kuala Lumpur. Poster. 14 Ratnavelu, K (Ratnavelu, Kuru), Fatt, CK (Fatt, Choong Kwai), Abu Ujum, E (Abu Ujum, Ephrance), 2nd International Conference of Mathematical Modelling and Scientific Computation (ICMMSC 2012) Location: Gandhigram, INDIA Date: MAR 16-18, 2012 MATHEMATICAL MODELLING AND SCIENTIFIC COMPUTATION Book Series: Communications in Computer and Information Science Volume: 283 Pages: 505-513 Published: 2012 15 Supramolecular Chemistry Based on Delocalised Metal(lone pair) π(arene) Interactions: The Story Thus Far, Cambodian Malaysian Chemical Conference (CMCC) 2012, 19 Oct 2012 to 21 Oct 2012, Institut Kimia Malaysia & Cambodian Chemical Society, (International) 16 Supramolecular Chemistry Based on Chelate Rings Functioning as Donors and Acceptors, 17th Malaysian Chemical Congress (17MCC) 2012, 15 Oct 2012 to 17 Oct 2012, Institut Kimia Malaysia, (National) 17 Supramolecular Synthons Based on Gold pi(arene) Interactions, GOLD2012, 05 Sep 2012 to 08 Sep 2012, World Gold Council, (International) 65 66 High Impact Research Annual Report 2012 18 Wan Melissa Diyana Wan Normazlan. Physicochemical investigation of binary and ternary mixtures of 1-ethyl-3-methylimidazolium diethylphosphate (EMIM DEP), propanol and water.17th Malaysian Chemical Congress (17MCC) 2012, 15-17th Oct 2012, Putra World Trade Centre, Kuala Lumpur. Poster. 19 Wan Melissa Diyana Wan Normazlan, Nor Asrina Sairi and Yatimah Alias. Physicochemical investigation of binary and ternary mixtures of 1-ethyl-3-methylimidazolium diethylphosphate (EMIM DEP), propanol and water. 5th Australasian Symposium on Ionic Liquids (ASIL5), 3-4 May 2012, Monash University, Australia. Poster. 7 FACULTY OF COMPUTER SCIENCE INFORMATION & TECHNOLOGY 1 Rahman M. Z., A Combined Arithmetic Logic Unit and Memory Element for the Design of a Parallel Computer, Lecture Notes in Computer Science, Vol. 7016/2011, pp. 306-317, October, 2011, doi:10.1007/978-3-642-24650-0_26. 2 K. Wong, S. Ong, and K. Tanaka. Improvement of carrier capacity for scalable scrambling method with reversible information insertion functionality. IEEE Conference on Signal and Image Processing Applications (ICSIPA), 16 - 18 Nov. 2011, Kuala Lumpur, Malaysia; pp. 312 – 317 3 KokSheik Wong, Simying Ong, Kiyoshi Tanaka and Xiaojun Qi, “Bitstream Size Suppression for DCT-based Information Hiding Method”, IEEE International Symposium on Intelligent Signal Processing and Communication Systems (ISPACS), 7-9 Dec. 2011, Chiang Mai, Thailand; pp. 1-5 (Best paper award) 4 S. Ong, K. Wong, and K. Tanaka, “Reversible Data Embedding using Reflective Blocks with Scalable Visual”, IEEE International Conference on Intelligent Information Hiding and Multimedia Signal Processing (IIH- MSP), 18-20 July 2012, University of Piraeus, Greece; pp. 363 – 366 5 Muhammad Shiraz , Abdullah Gani, Rashid Hafeez Khokar, Rajkumar Buyya A Review on Application Processing Frameworks in Mobile Devices for Mobile Cloud Computing IEEE Communications Surveys and Tutorials, IEEE (ACCEPTED, DOI: 10.1109/ SURV.2012.111412.00045, ISI Indexed Q1 (impact factor 6.3)). 6 Yiqi Tew and KokSheik Wong, “A Survey of Information Hiding in H.264/AVC,” IIEEJ Proc. Image Electronics and Visual Computing Workshop 2012 (IEVC2012), 21-24 Nov. 2012, Kuching, Malaysia; CD-ROM FACULTY OF DENTISTRY 1 2 3 4 5 6 Cheong SC, IKN Chiang, KP Lim, CP Gan, KK Sam, RB Zain, MT Abraham, WMW Mustafa, ZAA Rahman. Establishment of in vitro Models for Oral Cancer: Understanding How Key Genetic Changes Drive Cancer for the Development of Targeted Therapy. 6th APOCP: Clinical Epidemiology and Practical Interventions - The future of Cancer Control in Asia Pacific Region, 26th-29th April 2012, Pullman Kuching, Malaysia. Abstract no FP 3.5; pp 75. N.S. Abdullah, N.F.M. Radzali, R. Saub, R.D. Vaithilingam. Oral Health-Related Quality Of Life Of A Selected Malaysian Adult Population. Europerio 7, 6-9 June 2012, Vienna, Austria. J Clin Periodontol 2012 (ISI cited); Abstacts of Europerio 7, P0276; pg 160. Yong CC, John J, Koutronas E, Kallarakkal TG. Cost estimation and planning for HIV/AIDS oral healthcare services: a Malaysian experiment. First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012) Chennai, India. 20-22 January 2012. BMC Infectious Diseases 2012, 12(Suppl 1):P93 DOI:10.1186/1471-2334-12-S1-P93 Joshi VK, John J, Esa R, Gomez MA, Kallarakkal TG, Nambiar PK, Ramanathan A, Baharuddin NA, Mani SA. Developing Empathy in Dental Students. 21st Congress of the International Association for Disability and Oral Health (IADH 2012) Melbourne, Australia. 28-31 October 2012. Journal of Disability and Oral Health 2012, 13(3): 118 John J, Joshi VK, Esa R, Gomez MA, Kallarakkal TG, Nambiar PK, Ramanathan A, Baharuddin NA, Mani SA. Oral health care needs and OHRQoL among prison inmates with HIV/AIDS – creating a Community-Prison Link. 21st Congress of the International Association for Disability and Oral Health (IADH 2012) Melbourne, Australia. 28-31 October 2012. Journal of Disability and Oral Health 2012, 13(3): 114 John J. Mobile Prosthodontist. 8th Biennial Meeting of AAP and 40th Indian Prosthodontic Society Conference (AAP-IPS 2012) Chennai, India. 5-9 December 2012 Rosnah Binti Zain, Cheong Sok Ching, Vincent Chong Vui King, Karen Ng Lee Peng. Harnessing Genomic Information for Patient Benefit- The Malaysian Oral Cancer Scenario. 10th AsiaPacific Conference on Human Genetics, Genetic and Genomic Medicine: Working Together Towards Health for All, 5th-8th December 2012, Crowne Plaza Mutiara Hotel, Kuala Lumpur, MALAYSIA. CHANCELLORY 1 Loke Mun Fai, Khosravi Yalda, Nur Siti Khadijah Ramli, The Xinsheng, Gunaletchumy Selva Perumal, Goh Khean Lee and Vadivelu Jamuna (2011) Interspecies Molecular Crosstalk in Helicobacter Pylori infections. 2nd International Student Conference on Microbial Communication, 13 Sep 2011 to 16 Sep 2011 Jena, Germany High Impact Research Annual Report 2012 2 Talkative bacteria: Can we stop them from chit chatting?, Molecular Biology Seminar - AIMBN Delegation to UM, 11 Apr 2011 to 11 Apr 2011, UM Biotech Cluster, (International) 3 Detection of N−acyl homoserine lactone, virulence factors and quorum quenching activity from Potential Pathogen isolated from diseaseassociated Tilapia Fish,2nd International Student Conference on Microbial Communication (MiCom2011), 13 Sep 2011 to 16 Sep 2011, Jena School of Microbial Communication, (International) 4 Anti-quorum sensing properties of Melicope lunu-ankenda, Piper nigrum, Piper betle and Gnetum gnemon, The 2nd International Conference on Atimicrobial Research- ICAR2012, 21 Nov 2012 to 23 Nov 2012, Formatex Research Center, (International) 5 Ancient wisdom versus global antibiotic resistance: Discovery of anti-quorum sensing molecules as new hits and leads for next generation anti-infective therapy, Central European Symposium on Antimicrobials and Antimicrobial Resistance, 23 Sep 2012 to 26 Sep 2012, Croatian Microbiological Society in collaboration with Microbiological Societies from Czech Republic, Slovakia, Hungary and Bosnia and Herzegovina 6 7 8 9 High-throughput metagenomic analysis of the microbial community at Ulu Slim Hot Spring, Malaysia, The 17th Biological Sciences Graduate Congress,08 Dec 2012 to 10 Dec 2012, Chulalongkorn University, University of Singapore (DBS-NUS) and the Malaya University., (International) SP Gunaletchumy, JN Mason, A Saidin, XS Teh, NSK Ramli, Y Khosravi1, MF Loke, HM Mitchell, KL Goh, Vadivelu J. (2012) Whole genome analysis of Helicobacter pylori. (2012) The 2nd Asian Pacific topic conference Asian Pacific Helicobacter pylori Meeting 2012, 13 Jan 2012 to 15 Jan 2012, Kuala Lumpur Malaysia XS Teh, Y Khosravi, SP Gunaletchumy, NSK Ramli, MF Loke, KL Goh, J Vadivelu. (2012) Prevalence of Helicobacter pylori antibiotic resistance pattern in Malaysia. The 2nd Asian Pacific topic conference Asian Pacific Helicobacter pylori Meeting 2012, 13 Jan 2012 to 15 Jan 2012, Kuala Lumpur Malaysia Y Khosravi, SW Seow, XS Teh, NSK Ramli, SP Gunaletchumy, MF Loke, RM Bunte, S Pettersson , KL Goh, J Vadivelu. (2012) Gut microbiota and Helicobacter pylori infections. The 2nd Asian Pacific topic conference Asian Pacific Helicobacter pylori Meeting 2012, 13 Jan 2012 to 15 Jan 2012, Kuala Lumpur Malaysia 10 Y Khosravi, XS Teh, SP Gunaletchumy, NSK Ramli, MF Loke, KL Goh, J Vadivelu. (2012) Interspecies molecular crosstalk in Helicobacter pylori infection. The 2nd Asian Pacific topic conference Asian Pacific Helicobacter pylori Meeting 2012, 13 Jan 2012 to 15 Jan 2012, Kuala Lumpur Malaysia 11 NSK Ramli, XS Teh, Y Khosravi, SP Gunaletchumy, MF Loke, K Hardie, KL Goh, J Vadivelu. (2012) Helicobacter pylori quorum sensing in a multispecies consortium. The 2nd Asian Pacific topic conference Asian Pacific Helicobacter pylori Meeting 2012, 13 Jan 2012 to 15 Jan 2012, Kuala Lumpur Malaysia 12 Selva Perumal Gunaletchumy, Xinsheng Teh, Yalda Khosravi, Nur Siti Khadijah Ramli, Eng Guan Chua, Thevakumar Kavitha, Joanne N. Mason, Huey Tyng Lee, Halimah Alias, Nur Zafirah Zaidan, Norzawani Buang M. Yassin, Liang Chung Tay, Stephen Rudd, Hazel M.Mitchell, Nadeem O. Kaakoush, Mun Fai Loke, Khean Lee Goh, and Jamuna Vadivelu Genomic Structure and Diversity of Helicobacter pylori Strains from Malaysia, 10th International Workshop on pathogenesis and Host Response in Helicobacter Infections, 04 Jul 2012 to 07 Jul 2012, European Study Group on Pathogenesis and Immunology in Helicobacter Infections and European Helicobacter Study Group (EHSG), (International) 13 Puvaneswari M, Nur Aishah MT, Zamri C, Nirmala BP, Ho GF, Yip CH,Kanga RS, Kalanithi N. ocotrienols and Breast Cancer – A Review ofRecent Findings. 6th General Assembly Asian Pacific Organisation for Cancer Prevention:Clinical Epidemiology and Practical Interventions –the Future of Cancer Control in the Asian Pacific Region. 26th-29th April 2012. Pullman Hotel, Sarawak, Malaysia. 14 Hassan N, Mohd Taib NA, Yip CH, Teo SH, Yoon SK, Thing MK. Risk of breast cancer in Malaysian BRCA1 and BRCA2 carriers. Asia Pacific Conference of Human Genetics, Genetic and Genomic Medicine; Working Together Towards Health for All, 5-8 December 2012. Crowne Plaza Hotel, Kuala Lumpur. APCHG Abstract no 216 15 Hassan N. SNP profiling in determining risk to breast cancer in Malaysia’s multi-ethnic population. Working With the Human Genome Sequence Workshop by Wellcome Trust Major Overseas Programme, 3-6 December 2012, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, pp v. 16 Rifhan Azwani M, Thong MK and Nur Aishah Taib. Market Survey - Genetic Counseling (GC) among Medical Practitioners and Students of Faculty of Medicine, University of Malaya. 10th Asia Pacific Conference on Human Genetics (APCHG), 5th December - 8th December 2012, Crown Plaza Hotel Kuala Lumpur, Malaysia. Poster Presentation Abstract ID no:148. 17 Kwan-Hoong Ng. How useful is volumetric breast density in predictiong breast cancer risk? 27th Malaysia-SingaporeRadiographers’ Conference, 14 - 16 September 2012, Merdeka Palace Hotel & Suite Kuching, Sarawak. 18 Kwan-Hoong Ng. How useful is volumetric breast density in predictiong breast cancer risk? 10th South East Asian Congress of Medical Physics, The 12th Asia Ocenia Congress of Medical 67 68 High Impact Research Annual Report 2012 Physics, 11 -14 Disember 2012, Khum Phu Come Hotel, Chiang Mai, Thailand. 19 Hassan N, Mohd Taib NA, Yip CH, Teo SH, Yoon SK, Thing MK. Risk of breast cancer in Malaysian BRCA1 and BRCA2 carriers. Asia Pacific Conference of Human Genetics, Genetic and Genomic Medicine; Working Together Towards Health for All, 5-8 December 2012. Crowne Plaza Hotel, Kuala Lumpur. APCHG Abstract no 216. 20 Liew YW, Ng KH, Abdul Aziz YF. Measuring breast density from digital mammograms. University of Malaya Research Imaging Centre (UMRIC) Presentation, 26 April 2012. 21 Liew YW, Ng KH, Abdul Aziz YF. Breast density quantification in UMMC. Breast density research seminar, 20 February 2012. 22 EC Lee, Z Mohamed, SH Teo, NA Mohd Taib, GF Ho, CH Yip. The effect of CYP2D6 genetic polymorphisms on survival in Malaysian women with ER positive breast cancer treated with tamoxifen. 6th General Assembly Asian Pacific Organization for Cancer Prevention, 26-29 April 2012, Pullman Hotel, Kuching, Sarawak, Malaysia. PP16; page 105. 23 Phuah SY, Looi LM, Rhodes A, Dean S, MohdTaib NA, Yip CH and Teo SH. Addition of ER and PTEN, but not cytokeratins, aids identification of BRCA1 carriers in Malaysian breast cancer patients. AACR (American Association for Cancer Research) Annual Meeting, 31st March till 4th April 2012, Mc.Cormick Place in Chicago, Illinois, USA. Abstract no: 2609 24 Phuah SY, NA MohdTaib, Yip CH and Teo SH. Prevalence of BRCA1 and BRCA2 mutations among Malaysian breast cancer patients: Update from the Malaysian Breast Cancer Genetic Study (MyBrCa). Asia Pacific Conference of Human Genetics, Genetic and Genomic Medicine; Working Together Towards Health for All, 5-8 December 2012.Crowne Plaza Hotel, Kuala Lumpur. Abstract no: 219 25 Phuah SY, Lee SY, Kang IN, Kang P, MohdTaib NA, YIP CH and Teo SH. Prevalence of PALB2 (Partner and Localizer of BRCA2) mutation in the Malaysian breast cancer genetic study (MyBrCa). Asia Pacific Conference of Human Genetics, Genetic and Genomic Medicine; Working Together Towards Health for All, 5-8 December 2012.Crowne Plaza Hotel, Kuala Lumpur. Abstract no: 217 26 Mariapun S, Phuah SY, Yip CH, MohdTaib NA, Teo SH. Breast cancer risk factors in a Malaysian cohort: A case control analysis. Annual Scientific Congress of Malaysian Oncological Society - Effective Cancer Treatment: Updating Professionals, Educating the Public, 6th-9th September 2012. Equatorial Hotel Melaka 27 Soo SS, Leong CO, Ng CH &Teo SH. Combination of metformin and FEC chemotherapy works synergistically on basal breast cancer cell lines but not on cancer stem cells. 6th General Assembly of Asia Pacific Organisation for Cancer Prevention: Future of Cancer Control, 26-29 April 2012, Pullman Hotel, Kuching Sarawak. Poster Presentations no PP27; pp 116. 28 Soo SS, Hassan N, Teh YC, Harun F, Yanan N, MohdTaib NA, Yip CH, Teo SH. Association of diabetes and tumour characteristics of breast cancer in Malaysian breast cancer patients. Annual Scientific Congress of Malaysian Oncology Society: Effective Cancer Treatment: Updating Professionals, Educating the Public, 6-9 September 2012, Equatorial Hotel Melaka, Malacca. Poster Presentations no. 8. 29 Kang IN, Peter-Kang, Yip CH, MohdTaib NA, Teo SH. A rapid and robust classification of BRCA VUS in a case-control series using highthroughput Sequenom® platform increases understanding of cancer risk in cancerpredisposed patients. Asia Pacific Conference of Human Genetics, Genetic and Genomic Medicine; Working Together Towards Health for All, 5-8 December 2012.Crowne Plaza Hotel, Kuala Lumpur. APCHG Abstract no 222. 30 Kang PCE, Kang IN, Sivanandan K, Thirthagiri E, Phuah SY, Miao H, Hartman M, Yoon SY, Thong MK, MohdTaib NA, Yip CH, Teo SH. BRCA1 & BRCA2 Mutations in Malaysian Breast Cancer Patients. Asia Pacific Conference on Human Genetics 5- 8 Dec 2012, Crown Plaza Hotel, Kuala Lumpur, Asia Pacific Conference on Human Genetics (APCHG) abstract no. 229 31 K. D. Dambul, G. A. Mahdiraji, F. Amirkhan, Desmond M. Chow, Gabriel K.W. Gan, W.R. Wong, M.R. Abu Hassan, Sarahah Ismail, S.A. Ibrahim, N. Tamchek and F.R. Mahamd Adikan Fabrication and Development of Flat Fibers Photonics Global Conference,singapore, 2012 32 D. M. Chow, D. C. Tee, S. R. Sandoghchi, and F. R. Mahamd Adikan, “Direct UV Written Waveguide’s Dispersion in Flexible Silica Flat Fibre Chip,” in Specialty Optical Fibers, OSA Technical Digest (online) (Optical Society of America, 2012), paper SM2E.4. http://www. opticsinfobase.org/abstract.cfm?URI=SOF-2012SM2E.4 33 Jahanshahi, P.; Ghomeishi, M.; Adikan, F.R.M.; , “Adhesive layer effect on goldsilica thin film interfaces for surface plasmon resonance modeling,” Photonics (ICP), 2012 IEEE 3rd International Conference on , vol., no., pp.89-92, 1-3 Oct. 2012 doi:10.1109/ICP .2012.6379841 URL:http://ieeexplore.ieee.org/ stamp/stamp .jsp?tp=&arnumber=6379841 &isnumber=6379517 34 Yeo, K.S.; Chow, D.M.C.; Tee, D.C.; Wong, W.R.; Sandoghchi, S.R.; Mahdi, M.A.; Adikan, F.R.M.;, “Dispersion modeling of solid core photonic crystal fiber,” Photonics (ICP), 2012 IEEE 3rd International Conference on , vol., no., pp.224-226, 1-3 Oct. 2012 doi: 10.1109/ ICP.2012.6379823 URL:http://ieeexplore.ieee. org/stamp/stamp.jsp?tp=&arnumber=6379823&i snumber=6379517 35 Chow, D.M.; Sandoghchi, S.R.; Adikan, F.R.M.; “Fabrication of photonic crystal fibers,” High Impact Research Annual Report 2012 Photonics (ICP), 2012 IEEE 3rd International Conference on , vol., no., pp.227-230, 1-3 Oct. 2012 doi: 10.1109/ICP.2012.6379830 URL: http:// ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnum ber=6379830&isnumber=6379517 36 Poh, A.H.; Adikan, F.R.M.; Bakar, M.H.A.; , “A mounting method on configuring a wavelengthvoltage relation of an optical tunable bandpass filter (TBF) for actuation & control,” Photonics (ICP), 2012 IEEE 3rd International Conference on , vol., no., pp.327-330, 1-3 Oct. 2012 doi: 10.1109/ICP.2012.6379833 URL: http:// ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnum ber=6379833&isnumber=6379517 37 Hisham, H.K.; Abas, A.F.; Mahdiraji, G.A.; Mandi, M.A.; Adikan, F.R.M.; , “Effect of temperature and external optical feedback on intensity and phase noise characteristics in single-mode fiber grating Fabry-Perot laser,” Photonics (ICP), 2012 IEEE 3rd International Conference on , vol., no., pp.370-376, 1-3 Oct. 2012 doi: 10.1109/ ICP.2012.6379846 URL: http://ieeexplore.ieee. org/stamp/stamp.jsp?tp=&arnumber=6379846& isnumber=6379517 HIR 2 YEARS PROJECT - 2010 1 Alhoot MA and Sekaran SD (2010). RNA interference inhibits dengue virus entry ang=d multiplication into monocytes by silencing CD14 associated molecule. The 17th International Student Congress of Medical Sciences (ISCOMS) meeting in Groningen, The Netherlands. 2 Alhoot MA and Sekaran SD (2010). Inhibition of dengue virus entry and multiplication into monocytes by silencing CD-14 associated molecule using RNA interference. Colloqium on Updates on Dengue and Arbovirus Research in Malaysia. 3 Alhoot MA and Sekaran SD (2010). Inhibition of dengue virus entry and multiplication into monocytes by silencing CD-14 associated molecule using RNA interference. Colloqium on Updates on Dengue and Arbovirus Research in Malaysia. Appanna R, Lucy LSM, Wang SM and Sekaran SD (2010). Cross-reactive T cells, HLA Types, Cytokine Profiles and Endothelial Leakage and Their Association in Dengue Infection. Innovation & Creativity EXPO University of Malaya. 4 Alhoot MA and Sekaran SD (2010). Silencing of the CD-14 molecule on macrophages prevents entry of dengue virus into monocytes. Innovation & Creativity EXPO University 6f Malaya. 5 Appanna R, Lucy LSM, Wang SM and Sekaran SD (2010). Cross-reactive T cells, HLA Types, Cytokine Profiles and Endothelial Leakage and Their Association in Dengue Infection. Innovation & Creativity EXPO University of Malaya. Lee SK, Fong MY and Sekaran SD(2010). Genetic of Silent Infection in Dengue. Innovation & Creativity EXPO University of Malaya. 6 Appanna R, Lucy LCS and Sekaran SD (2010). Immunological Determinants and Associations with Dengue Infections. Colloquium on Updates on Dengue and Arbovirus Research in Malaysia 7 Chan SY, Sam IC, Chan YF. Replication kinetics of Enterovirus 71 and Coxsackievirus A16 in neuronal and intestinal cells. My1Bio conference, Kuala Lumpur, 30-31 October, 2010. 8 Klekamp B, Mayer C, Appanna R, Komarasamy TV, Rathakrishnan A, Lee SK, Cheong HC, Wang SM, Azizan A, Sanhez-Anguiano A, Sathar J, and Sekaran SD (2010). Immunilogical and genetic profiles in the progression of dengue disease. 3rd Annual Graduate Student Research 9 Lee SK, Fong MY and Sekaran SD(2010). Genetic of Silent Infection in Dengue. Innovation & Creativity EXPO University of Malaya. 10 Alhoot MA and Sekaran SD (2010). Silencing of the CD-14 molecule on macrophages prevents entry of dengue virus into monocytes. Innovation & Creativity EXPO University of Malaya. 11 PMMA-LiBOB Gel Electrolyte for lithium Ion Batteries, XII International Symposium on Polymer Electrolytes, (ISPE 12), Padova, Italy, 29 August - 3 September 2010. 12 Pilban S, Zak AK, Abd Majid WH, Muhamad MR. Synthesis and Characterization of Lead Calcium Titanate Nanocomposite. Malaysia Annual Physics Conference 27-30 Oct 2010 (PERFIK-2010), Damai Laut, Malaysia. AIP Conf. Proc. Vol.1328 pp. 183-185. DOI:10.1063/1.3573723 13 Chan YF. Phylogenetic designation of EV71 genotypes and subgenotypes. The 1st International Symposium of Vaccine Development against Human Hand-Foot-andMouth Diseases. 4-5 September 2011, Zhunan, Taiwan. (Invited speaker). 14 Chan YF. Enterovirus 71: a decade later. 9th Biennial Convention of the Asean Neurological Associaiton (ASNA): Neuroinfection symposium. 2- 5 November, 2011. (Invited speaker) 15 Chan SY, Sam IC, Chan YF. Differential Proteome analysis of human colon adenocarcinoma cells infected with enterovirus 71 and coxsackievirus A16. 1st International Symposium of Infectious Diseases and Signal Transduction Research. 1920 November 2011, Tainan, Taiwan. (Poster) 16 Chiam CW, Chan YF, Ong KC, Wong KT, Sam IC. Neurovirulence variation of different Chikungunya virus genotypes in ICR suckling mice. 16th Biological Sciences Graduate Congress, 1214th December 2011, National University of Singapore, Singapore. 17 C.H. Lim and C.S. Chan. A Framework on Fuzzy Intrusion Detection. International Workshop on Advanced Computational Intelligence and Intelligent Informatics, 19-23 November 2011, Suzhou, China. 18 Choo, Y. M. “Malaysian Terrestrial Plants and Microorganisms: Source of New Leads”, The 6th International Conference on Cutting-Edge 69 70 High Impact Research Annual Report 2012 Organic Chemistry in Asia 11-15 December 2011 Hong Kong methymethacrylate”, presented at Malaysia Polymer International Conference, 18 – 20 Oct 2011, Bangi, Selangor, (selected to be published in Jurnal Sains Malaysiana). 19 Helen-Ng LC, Razak IA, Ghani WMN, Marhazlinda J, Norlida A, Zain RB. Dietary consumption pattern and risk of oral cancer – a Malaysia scenario. 3rd World Congress of the International Academy of Oral Oncology, Yin and Yang: Balancing Cure and Consequences, 14-17 July 2011, Grand Copthorne Waterfront Hotel, Singapore. Oral Oncology Abstract no P98; pp 105. 29 Tan CW, Chan YF, Tan EL, Sim KM, Poh CL. Inhibition of enterovirus 71 infections by a novel peptide derived from enterovirus 71 capsid protein VP1. 1st International Symposium of Infectious Diseases and Signal Transduction Research. 19-20 November 2011, Tainan, Taiwan. (Poster) 20 K.B.Md Isa, L.Othman, M.Mansor and Z.Osman, “Ionic Conductivity And Transference Number Studies of PVDF-HFP/PMMA – (EC+PC) Gel Polymer Electrolytes Containing Lithium Salt”, presented at Malaysia Polymer International Conference, 18 – 20 Oct 2011, Bangi, Selangor, (selected to be published in Jurnal Sains Malaysiana). 30 Y.H. Kong, S.N. Syed Zanaruddin, W.M.N. Ghani, Z.A. Abdul Rahman, M.T. Abraham, R. Anand, S.H. Lau, R.B. Zain and Sok Ching Cheong. Expressions of EMT markers are associated with pattern of invasion in oral cancer. 4th Regional Conference on Molecular Medicine, 9 - 11 October 2011, G-Hotel, Gurney Drive, Penang, Malaysia. RCMM Absract no OP11, pg. 35 21 K.H. Thung, P. Raveendran, Similarity Measure of Moment Vectors as Image Quality Measures,” IVCNZ 2011, Twenty-sixth International Conference Image and Vision Computing, 29 Nov - 1 Dec, 2011, Auckland, New Zealand. 31 Yeo GN, Woon KL. Influence of Series Resistance, Shunt Resistance and Interface Properties on Fill Factor of P3HT/PCBM Organic Photovoltaic- 26th Regional Conference on Solid State Science and Technology 2011, 22-24 November 2011, The Royale Bintang Seremban, Negeri Sembilan, Malaysia. RCSSST Abstract no C10. 22 L.Othman, S.M.Samin, N.H.Zainol, K.B.Md Isa and Z.Osman, “Lithium Ion Conduction Studies of Gel Polymer Electrolytes Based on PMMA”, presented at Malaysia Polymer International Conference, 18 – 20 Oct 2011, Bangi, Selangor. 23 M.A. Freeman, A. Horák, M. Eydal, P. Keeling 2011. X-cell parasites of Atlantic cod are basal dinoflagellates.Oral presentation: VI European Congress of Protistology (ECOP VI). Berlin, Germany 25th-29th July.M.A. Freeman, A. Horák, M. Eydal, P. Keeling 2011. X-cell parasites of Atlantic cod are basal dinoflagellates. 24 M.I.M.Ghazali, L.Othman, K.B.Md Isa and Z.Osman, “Ionic Conductivity and Structural Studies of PMMA+EC+PC+LiBF4 Gel Polymer Electrolytes”, presented at Malaysia Polymer International Conference, 18 – 20 Oct 2011, Bangi, Selangor, (selected to be published in Jurnal Sains Malaysiana). 25 K.H. Thung, P. Raveendran, Similarity Measure of Moment Vectors as Image Quality Measures,” IVCNZ 2011, Twenty-sixth International Conference Image and Vision Computing, 29 Nov - 1 Dec, 2011, Auckland, New Zealand. 26 Razali R, Zak AK, W. H. Abd. Majid, M. Darroudi, Solvothermal synthesis of microsphere ZnO nanostructures in DEA media, International Symposium on Advanced Materials for Optics Microelectronics ana Nanoelectronics AMOMEN 27-30 Oct 2011, Ibn Tofail University, Kenitra, Morocco. 27 Romano Ngui, Yvonne AL Lim, Rebecca Traub, Rohela Mahmud, Mohd Sani Mistam. Molecular characterization of hookworms from human and domestic carnivores in rural areas of Malaysia. Joint International Tropical Medicine Meeting (JITMM), Bangkok, Thailand. 1-2nd December 2011. (Oral). 28 S.M.Samin, K.B.Md. Isa, L.Othman and Z.Osman, “Li-Ion conduction and Structural Studies of GPE based on Poly 32 Zak AK, Abd Majid WH, Gan WC. Experimental and Theoretical Dielectric Studies of PVDF/ PZT Nanocomposite Thin Films, International Symposium on Advanced Materials for Optics Microelectronics and Nanoelectronics AMOMEN 27-30 Oct 2011, Ibn Tofail University, Kenitra, Morocco. 33 Z.Osman, M.F.Zulkifli, K.B.Md Isa and L.Othman, “Preparation and Characterization of Gel Polymer Electrolytes Based on PVDF-HFP/PMMA Blend”, presented at Malaysia Polymer International Conference, 18 – 20 Oct 2011, Bangi, Selangor. 34 Yeo Adeline, Wang SM, Sekaran SD (2012). Comparison of neutralizing antibodies of dengue patients with their asymptomatic household members. 9th Asia Pacific Congress of Medical Virology in Adelaide, Australia. 35 Rathakrishnan A and Sekaran SD (2012). The presentation was entitled : Dengue specific HLA-restricted T-Cell Response and Cytokine Profiling of Dengue Patients in Malaysia. 9th Asia Pacific Congress of Medical Virology in Adelaide, Australia. 36 Rathakrishnan A and Sekaran SD (2012). The presentation was entitled : Dengue specific HLA-restricted T-Cell Response and Cytokine Profiling of Dengue Patients in Malaysia. 9th Asia Pacific Congress of Medical Virology in Adelaide, Australia. 37 Frontiers in Polymers, Lyon 29-31 May 2011 Effect of fillers on ionic conductivity of PANbased gel and composite electrolytes for possible applications in lithium batteries, XIII International Symposium on Polymer Electrolytes (ISPE 13), Iceland (26-31 August 2012). 38 Yeo Adeline, Wang SM, Sekaran SD (2012). Comparison of neutralizing antibodies of dengue patients with their asymptomatic household High Impact Research Annual Report 2012 members. 9th Asia Pacific Congress of Medical Virology in Adelaide, Australia. 39 Effect of fillers on ionic conductivity of PANbased gel and composite electrolytes for possible applications in lithium batteries, XIII International Symposium on Polymer Electrolytes (ISPE 13), Iceland (26-31 August 2012). 40 N.H. Zainol and Z. Osman, “Studies of Ionic Transport and Morphological Properties of PMMA-Gel Polymer Electrolytes Containing Magnesium Ions”, presented at International Conference of Young Researchers on Advanced Materials, 1 – 6 July 2012, Singapore. 41 Siti Mariam Samin, Lisani Othman, Khairul Bahiyah Md Isa, Mazwan Mansor and Zurina Osman, “Effect of PVDF-HFP on Ionic Conductivity, Structural and Morphological Studies in PMMA/PVDF-HFP Blend Gel Polymer Electrolytes”, presented at International Conference of Young Researchers on Advanced Materials, 1 – 6 July 2012, Singapore. Biotechnology 2012. 30 October, 2012 University Malaya. (Young Investigator awarded to student Tan Chee Wah) 48 Chiam CW, Loong SK, Chan YF, Sam IC. Development of strand-specific quantitative realtime polymerase chain reaction for Chikungunya virus. 9th Asia-Pacific Congress of Medical Virology, 6-8th June 2012, Adelaide Convention Centre, Australia. 49 Musa S and Govindasamy V. Dental Pulp Stem Cells – Its Characteristics and Therapeutic Potential. Programme and abstract book of BIT’s 5th World Congress of Regenerative Medicine and Stem Cells 2012, 2-4 Disember 2012, Guangzhou, China. Oral presentation. Abstract pp. 165. 50 Lim, C.K. and Chan, C.S. Fuzzy Set and Multi Description Property. IEEE International Conference on Fuzzy Systems (IEEE World Congress on Computational Intelligence), 10 -15 June, 2012, Brisbane, Australia, pp. 1-8. 42 N. H. Zainol, Z. Osman and L. Othman, “Transport and Morphological Properties of Gel Polymer Electrolytes Containing Mg(CF3SO3)2” – presented at International Materials Technology Conference and Exhibition, 9 – 12 July 2012, Sunway Resort Hotel and SPA, Selangor. 51 Lim, C.H. and Chan, C.S. A Fuzzy Qualitative Approach for Scene Classification. IEEE International Conference on Fuzzy Systems (IEEE World Congress on Computational Intelligence),10-15 June 2012, Brisbane, Australia, pp. 1-8. 43 Z. Osman, K. B. Md Isa and L. Othman, “Ion Transport and Morphological Properties of Gel Polymer Electrolytes Based on PVDF-HFP” – presented at International Confererence on Materials Science and Technology, Kottayam, India, 10-14 June 2012. 52 Guan Ni Yeo; Kai Lin Woon, Electrical Tunable Open Circuit Photovoltages From Polarization Enhanced Organic Photovoltaic Cells, ICSSST , 18-20 Dec 2012, Holiday Inn, Melacca Copthorne Waterfront Hotel, Singapore. Oral Oncology Abstract no P98; pp 105. 44 L. Othman, K. B. Md Isa, Z. Osman and R. Yahya, “Ionic Conductivity, Morphology and Transport Number of Lithium Ion in PMMA Based Gel Polymer Electrolytes”, presented at 8th International Conference on Diffusion in Solids and Liquids 2012, Istanbul, Turkey, 25-29 June 2012. 53 Abd Majid WH. Thin film composite and their potential application. 8th Mathematica and Physica Science Graduate Congress (8th MPSGC), 8-10 Dec 2012 Chulalongkorn University, Bangkok, Thailand. 45 VK Vincent-Chong, WMW Mustafa, Y-H Yang, A Arif, LP Karen-Ng, ZAA Rahman, SK Cheong, SM Ismail, PP Jayaprasad, ZM Zaini, N Prepageran, TG Kallarakkal, A Ramanathan, Y Hasmawati, MRN Shielawati, MT Abraham, KK Tay, RB Zain. Deletion of chromosome 20p13 in oral squamous cell carcinoma (OSCC) is associated with better overall survival of patients. 6th General Assembly Asian Pacific Organisation for Cancer Prevention, “Clinical Epidemiology and Practical Interventions – the Future of Cancer Control in the Asian Pacific Region”, 26-29 April 2012, Pullman Hotel Kuching Sarawak Malaysia. APOCP Absract no FP3.3 pp 73 46 Chan YF. Inhibition of enterovirus 71 infections by a novel peptide derived from enterovirus 71 capsid protein VP1. 7th National Infectious Diseases and Seminar and Workshop, 6 November 2012, University Putra Malaysia. (Invited speaker) 47 Tan CW, Sam IC, Poh CL, Chan YF. Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor. Malaysian Society of Molecular Biology and 54 Velayutham TS, Ng BK, Gan WC, Abd. Majid WH, Hashim R, Heidelberg T. Dielectric and pyroelectric properties of glycolipid (C14-10G2). The 8th Asian Meeting on Electro Ceramics. 1-5 July 2012 Penang, Malaysia. 55 Gan WC, Abd Majid WH, Furukawa T. Structural and Electrical Properties of Polar Alpha Poly(vinylidene fluoride) Thin Films. International Symposium on Integrated Functionalities (ISIF 2012),18-21 Jun 2012 di Hong Kong Polytechnic University, China. ISIF Abstract Book; pp 367. 56 Yap, A. C., Chan, K. G., and Choo, Y. M. “The Study of Secondary Metabolites from Proteobacteria”, The 7th International Conference on Cutting-Edge Organic Chemistry in Asia 11-14 December 2012 Nanyang Technology University, Singapore 57 Ngui R, Lim YAL, Liam CK, Chow SC and Shukri J. Association between anaemia, iron deficiency anaemia, neglected parasitic infections and socioeconomic factors in rural children of West Malaysia. 48th Annual Conference of the Malaysian Parasitology and Tropical Medicine (MSPTM). Infectious Disease in a Borderless World. Grand Seasons Hotel, Kuala Lumpur. 2728 March 2012. (Poster). 71 72 High Impact Research Annual Report 2012 HIR 2 YEARS PROJECT - 2011 1 Heng PL, Lee CW (2010) Production and loss rate of phototrophic picoplankton in tropical coastal waters. In: My1Bio, 8−10 October 2010, Berjaya Times Square, Kuala Lumpur (poster presentation) 2 Lim JH, Lee CW (2010) Phytoplankton productivity and mortality in tropical coastal waters. In: 15th Biological Science Graduate Congress, 15−17 December 2010, University of Malaya, Kuala Lumpur, Malaysia (poster presentation) 3 Abdullah, N.L., Mohd.-Zin, S.W., Mohammed, R.S., Pai, Y.J., Patrick, J.E., Thong, M.K., Marret, M., Aminah, A., Greene, N.D.E., Copp, A.J., Ahmad-Annuar, A., & Abdul-Aziz., N.M. The implications of Eph and ephrin signalling in neural tube closure. 2011 Neuroscience Symposium. 12 to 13 December 2011. NeuroMalaysia Society (Javan spitting cobra) venom and the effect of a neurotoxic polyvalent antivenom. Paper presented at the 17th Congress of the European Section of the International Society of Toxinology, Sep 11th-15th, 2011. Valencia, Spain 11 Abdullah, N.L., Mohd.-Zin, S.W., Mohammed, R.S., Pai, Y.J., Patrick, J.E., Thong, M.K., Marret, M., Aminah, A., Greene, N.D.E., Copp, A.J., Ahmad-Annuar, A., & Abdul-Aziz., N.M. Is the leading edge of neurulation an asymmetrical lamellipodia-like structure emanating from the surface ectoderm and whether this mirrors the human spina bifida condition? 19 to 29 September 2012. UCL, KCL, and NIMR at London, United Kingdom. 12 Abdullah, N.L., Mohd.-Zin, S.W., Mohammed, R.S., Pai, Y.J., Patrick, J.E., Thong, M.K., Marret, M., Aminah, A., Greene, N.D.E., Copp, A.J., Ahmad-Annuar, A., & Abdul-Aziz., N.M. Overcoming Spina Bifida – Personally, Experimentally and Clinically. Program Majlis Suai Kenal Beserta Ceramah Dan Kaji Selidik Spina Bifida. 3 November 2012. Spina Bifida Association of Malaysia. 4 Evaluation of The Antioxidant Activity In Lignosus SPP., Malaysian Society of Biochemistry and Molecular Biology Annual Conference, Eastin Hotel , Petaling Jaya, 27-28 August 2011 5 Helen-Ng LC, Razak IA, Ghani WMN, Marhazlinda J, Norlida A, Zain RB. Dietary consumption pattern and risk of oral cancer – a Malaysia scenario. 3rd World Congress of the International Academy of Oral Oncology, Yin and Yang: Balancing Cure and Consequences, 14-17 July 2011, Grand Copthorne Waterfront Hotel, Singapore. Oral Oncology Abstract no P98; pp 105. 6 Leong, P.K., Fung, S.Y., Sim, S.M. and Tan, N.H. (2011). Cross neutralization of some Southeast Asian cobra and krait venoms by Indian polyvalent antivenoms. Paper presented at the 17th Congress of the European Section of the International Society of Toxinology, Sep 11th15th, 2011. Valencia, Spain 14 Abdullah, N.L., Mohd.-Zin, S.W., Mohammed, R.S., Pai, Y.J., Patrick, J.E., Thong, M.K., Marret, M., Aminah, A., Greene, N.D.E., Copp, A.J., Ahmad-Annuar, A., & Abdul-Aziz., N.M. Adhesion and Fusion of the Spinal Neural Tube. Monthly Neuroscience Seminar Series 2012, Universiti Putra Malaysia. 25 April 2012. Neuroscience Research Cluster Monthly Seminar Series. 7 Pre-Commercialization of \’Cendawan Susu Harimau\’ (Lignosus Rhinocerus), International Invention , Innovation & Technology Exhibition (ITEX 2011), Kuala Lumpur, malaysia, 20-22 may 2011 (Gold medalist; Special Award Prix de salon de geneva ) 15 Lim JH and Lee CW (2012) Seasonal dynamics of phytoplankton production and loss rates in tropical coastal waters. In: 17th Biological Science Graduate Congress, 8-10 December 2012, Chulalongkorn University, Bangkok, Thailand. (oral presentation) 8 Tiger Milk Mushroom (Lignosus rhinocerus): Nutritional Content and Assessment Of Its Safety By Histological Examination of Vital Organs of Rats Fed With The Sclerotial Powder, Malaysian Society of Biochemistry and Molecular Biology Annual Conference, Eastin Hotel , Petaling Jaya, 27-28 August 2011 9 W. S. Chiu, S. A. Rahman, P. S. Khiew, T. K. Tan, S. Radiman, R. Abd-Shukor, M. A. Abd. Hamid, C. H. Chia, Time-Dependent Characterizations on Size Distribution of Fe3O4 Nanocrystals by Using Transmission Electron Microscope, 20th Scientific Conference of Microscopy Society of Malaysia & Extraordinary General Meeting, 2011, Permaisuri Resort, Port Dickson (Oral Presentation) 16 Abdullah, N.L., Mohd.-Zin, S.W., Mohammed, R.S., Pai, Y.J., Patrick, J.E., Thong, M.K., Marret, M., Aminah, A., Greene, N.D.E., Copp, A.J., Ahmad-Annuar, A., & Abdul-Aziz., N.M. Overcoming Spina Bifida – Personally, Experimentally and Clinically. Annual General Meeting of the Spina Bifida Association of Malaysia this Saturday. 14 April 2012. Spina Bifida Association of Malaysia. 10 Yap, M.K.K., Tan, N.H., Sim, S.M. and Fung, S.Y. (2011) Pharmacokinetics of Naja sputatrix 13 Abdullah, N.L., Mohd.-Zin, S.W., Mohammed, R.S., Pai, Y.J., Patrick, J.E., Thong, M.K., Marret, M., Aminah, A., Greene, N.D.E., Copp, A.J., Ahmad-Annuar, A., & Abdul-Aziz., N.M. Overcoming Spina bifida - Personally, Experimentally and Clinically. International Neuroscience Symposium. 23-25 July 2012. Universiti Malaysia Sabah and Brain Research Initiative Monash University (BRIMS) 17 Lim JH and Lee CW (2012) Seasonal dynamics of phytoplankton production and loss rate in tropical coastal waters. In: SCS 2012 Sharing knowledge, resources and technologies for a sustainable South China Sea. 21-24 October 2012, University of Malaya, Malaysia. (poster presentation) High Impact Research Annual Report 2012 18 Heng PL and Lee CW (2012) Potential production and loss rates of picocyanobacteria in tropical coastal waters. In: SCS 2012 Sharing knowledge, resources and technologies for a sustainable South China Sea. 21-24 October 2012, University of Malaya, Malaysia. (poster presentation) 19 Noraishah M. Abdul-Aziz, Mohammed R. Shaker, Aminah Abdullah & Nicholas D.E. Greene. Recent Advances in Prevention of Neural Tube Defects. 10th Asia-Pacific Conference on Human Genetics 2012. 5 – 8 December 2012. 20 Design and Rational for the Postoperative Vascular Events in Unrecognized Obstructive Sleep Apnea Trial. Edwin Seet, Matthew Chan, CY Wang, Stanley Tham, Frances Chung, Society of Anesthesia Sleep Medicine Annual Conference October 11-12, Washington, D.C , 2012. Best Clinical Research Presentation:First Prize Winner. 21 Discovery of a new Tiger Milk Mushroom Species from Malaysia, Lignosus cameronensis, ISMS 18, Beijing, China, 26-29 August 2012, pp 28 22 Breathing new life to a malaysian lost national treasure - the tiger milk mushroom (Lignosus rhinocerotis), ISMS 18, Beijing, China, 26-29 August 2012, OR1-2, pp7 23 Evaluations of the potential teratogenic and anti-fertility effects of lignosus rhinocerus (tiger milk mushroom) in rats, ISMS 18, Beijing, China, 26-29 August 2012, pp 170 24 Evaluation of antioxidant activity of Lignosus rhinocerus ( Tiger Milk Mushroom) sclerotia, ISMS 18, Beijing, China, 26-29 August 2012, P66, pp151 25 Anti-inflammatory activity of Lignosus rhinocerus (tiger milk mushroom), ISMS 18, Beijing, China, 26-29 August 2012, P6-5, pp150 26 Anti-proliferative activity of Tiger Milk Mushroom (Lignosus rhinocerus) and gene expression alterations of MCF-7 Breast cancer cells induced by treatment with the mushroom extract, ISMS 18, Beijing, China, 26-29 August 2012, P6-4, pp149 27 Molecular Phylogeny of Lignosus rhinocerus ( Tiger Milk Mushroom) based on complete 18S and 28S ribosomal DNA sequences, ISMS 18, Beijing, China, 26-29 , August 2012, P3-3, pp81 28 A.Z.S.Zulkifli, M.A.Kamarudin, A.Mainal, S.M.Said. NMR investigationof order parameter of liquid crtstal embedded in polivinyl alcoholbased polymer electrolytes. 4th International Conference of Solid State Science and Technology, ICSSST2012, 18-20 December, Holiday Inn Malacca, Malaysia. 29 M.A.Kamarudin,A.Z.S.Zulkifli, A.Mainal,S.M.Said. New liquid crystal-embedded polyvinyl alcoholbased polymer electrolyte for improved optical. 4th International Conference of Solid State Science and Technology, ICSSST2012,18-20 December, Holiday Inn Malacca, Malaysia. 30 N.A.A.M.Amin, D.A.A.Shnawah, M.F.M.Sabri, S.M.Said. Electrical Resitivity of Low Cost, High Reliability Element-added Lead-free Solder. 4th International Conference of Solid State Science and Technology, ICSSST2012,18-20 December, Holiday Inn Malacca, Malaysia. 31 M.A.Rahman, I.Yamana, G.Y.Yeap, S.M.Said, M. Kimura. Electro-optic potential of room and high temperature polymer stabilised blue phase liquid crystal. 4th International Conference of Solid State Science and Technology, ICSSST2012, 1820 December, Holiday Inn, Malacca, Malaysia. 32 W.S.Chiu, E.K.Chiew, S.X. Too, S. N. H. Daud, S. A. Rahman, A. Suhaimi Bakar, Z. Aspanut, P.S. Khiew, T.K. Tan, S. Radiman, R. AbdShukor, M. A. A. Hamid, C. H. Chia. Structural Characterization of Iron Oxide (Fe3O4) Magnetic Nanocrystals Prepared by Green Chemistry Approach, International Solid State Science & Technology, 2012, Holiday Inn Hotel, Melaka (Poster Presentation) 33 Chai H.K., Yorikawa M., Momoki S. and Terazawa M., “Damage assessment of fiber-reinforced concrete beams by stress wave velocity distribution”, The Fourth Asia-Pacific Young Researchers and Graduates Symposium, Hong Kong, Dec 2012, pg. 10-15 (Received Best Paper Award) 34 Kang YL, Ibrahim S, Saravanan P. Performance of Microbial Fuel Cell Inoculated with Mixed Culture from Anaerobic Lagoon. 7th Deans’ Meeting and Students’ Conference of the AsiaOceania Top University League in Engineering, Embracing New Horizons of Education and Innovation in Engineering and Technology, 24-25 November 2012, University of Malaya, Malaysia. Abstract no 160; pp 160. 35 Vythilingam, I. Plasmodium knowlesi Malaria in humans: An emerging public health problem. First International Congress on Tropical Medicine & Infectious Diseases. 4-7 December 2012. Impiana Hotel, Ipoh, Perak. Symposium11,pp31. 2. Vythilingam I. Ecology of malaria vectors and their Plasmodium parasites in Malaysia. XXIV International Congress of Entomology.20-24 Aug. EXCO, Daegu, Korea. Symposium1308, F01. pp110 36 Abu-Shariah M. Geoelectrical Resistivity Imaging Technique for Detecting Subterranean Cavity, International Conference on the Geology of the Arabian Plate and the Oman Mountains (ICGAPOM) 7- 9 January 2012 , Saltuan Qaboos University, Oman. Abstract Volume, pp6. 37 Shatirah Akib, Afshin Jahangirzadeh, Babak Kamali and Noor Liana Mamat, Sea Level Rise and Implication on Coastal Process: A Review. ASME 2012 31st International Conference on Ocean, Offshore and Arctic Engineering OMAE2012, July 1-6, 2012, Rio de Janeiro, Brazil. 38 Shatirah Akib, Afshin Jahangirzadeh, Lim Hong Wei, Sharif Moniruzzaman Shirazi, Sadia Rahman, “Experimental study on the skewed integral bridge by using crushed concrete geobags as scour protection”, 6th International Conference on Scour and Erosion ICSE 6, Aug 27-31, 2012, Paris, France. 73 74 High Impact Research Annual Report 2012 39 Afshin Jahangirzadeh, Shatirah Akib, Zubaidah Ismaill, Babak Kamali, Mahshid Kakouei, Arash Behnia, “Determination of Rectangular Collar Dimensions for Reducing Scour around Bridge Pier”, 6th International Conference on Scour and Erosion ICSE 6, Paris, France, Aug 27-31, 2012 40 Jahangirzadeh. A., Akib. S., Kamali. B., Rahman. S., Optimal water allocation: sustainable management of dam reservoir, International Conference on Architectural, Civil and Environmental Engineering. Paris, November, 2012 41 Kakouei, M., Kakouei, M., Subramanian, K., Musa Kahn, S., Jahangirzadeh, A., Akib, S., Masouleh: A City; A History, International Conference on Architectural, Civil and Environmental Engineering. Paris, November, 2012 42 Shatirah Akib, Nazirah Mashodi, Afshin Jahangirzadeh and S.M. Shirazi, “Semi-Integral Bridge Scour Countermeasure Using Gabion and Crushed Concrete Mixed with Palm Shell: A Review”, 5th ASEAN Civil Engineering Conference (ACEC), Ho Chi Minh, Vietnam, Oct 25-26, 2012 43 Prevathe Poniah, Zahurin Mohamed, Ivy Chung, Shanggar Kuppusamy, Azad Hassan Abdul Razack. Ethnic differences in prostate-specific antigen levels as indicator of disease severity in prostate cancer among Malaysians. 26th Scientific Meeting of Malaysian Society of Pharmacology & Physiology. 18-20 May 2012. Penang. LIST OF SUCCESSFUL APPLICANTS 2012 (HIR Projects – 2 Years) No. Faculty Principal Investigator (PI) Target output No. of Tier 1 ISI-Indexed Publications International Collaborations 1 Faculty of Medicine Assoc. Prof. Ong Teng Aik 5 4 2 Faculty of Science Prof. Dr. Muhammad Mazhar 6 0 3 FCSIT Dr. Hamid Abdulla Jalab 2 0 4 Faculty of Medicine Prof. Dr. Ng Kee Peng 3 0 5 Faculty of Medicine Dr. Wong Won Fen 3 3 6 Faculty of Medicine Dr. Esakimuthu Shankar 3 2 7 Faculty of Science Dr. Masatoshi Sone 5 3 8 Faculty of Engineering Assoc. Prof. Dr. Zubaidah Ismail 2 1 9 Faculty of Medicine Dr. Noraishah Mydin Haji Abdul Aziz 8 1 10 Faculty of Science Prof. Dr. Wan Ahmad Tajuddin Wan Abdullah 10 1 11 Faculty of Built Enviroment Prof. Dr. Hamzah Abdul Rahman 2 0 12 Faculty of Science Prof. Dr. Hapipah Mohd Ali 8 1 High Impact Research Annual Report 2012 LIST OF SUCCESSFUL APPLICANTS 2012 (HIR-MoHE Projects – 4 Years) No. Faculty Principal Investigator (PI) Target output No. of Tier 1 ISI-Indexed Publications International Collaborations 1 Faculty of Medicine Dr. Lau Yee Ling 32 NA 2 Faculty of Medicine Associate Profesor Dr. Visvaraja Subrayan 15 NA 3 Faculty of Medicine Profesor Dr. Shamala Devi A/P Sekaran 4 Faculty of Medicine Prof. Dr. Tunku Kamarul Zaman Tunku Zainol Abidin 5 Faculty of Medicine 6 Faculty of Engineering 7 8 9 2 NA NA Profesor Dr. Mohd Rais Mustafa 3 2 Professor Dr. Saad Mekhilef 28 2 Faculty of Engineering Professor Ir. Dr. Mohd Azlan Bin Hussain 15 3 Faculty of Engineering Prof. Dr. A.S.M.A Haseeb 20 NA 9 Faculty of Engineering Prof. Dr. Mohd Hamdi Abd Shukor 30 1 10 Faculty of Engineering Dr. Lim Einly 15 3 11 Faculty of Engineering Prof. Dr. Imtiaz Ahmed Chowdhury 27 3 12 Faculty of Engineering Dr. Suhana Mohd Said 21 1 13 Faculty of Engineering Dr. Brahim Si Ali 10 1 14 Faculty of Engineering Assoc. Prof. Dr. Shamsuddin Ahmed Mohammed Shahadat 12 2 15 Faculty of Engineering Prof. Dr. Nasarudin Abd Rahim 30 1 16 Faculty of Engineering Dr. Judha Purbalaksono 15 NA 17 Faculty of Engineering Prof. Dr. Roslan Hashim 30 1 18 Faculty of Engineering Assoc. Prof. Dr. Siti Zawiah Md. Dawal 15 4 19 Faculty of Engineering Prof. Ir. Dr. Mohd Zamin Jumaat 29 1 20 Faculty of Engineering Assoc. Prof. Ir. Dr. Abdul Aziz Abdul Raman 30 1 21 Faculty of Engineering Assoc. Prof. Ir. Dr. Abdul Aziz Abdul Raman 40 1 22 Faculty of Engineering Dr. Ahmad Khairi Abdul Wahab 30 1 23 Faculty of Engineering Assoc. Prof. Dr. Saidur Rahman Abdul Hakim 26 1 24 Faculty of Engineering Mr. Norhafizan Ahmad 24 1 25 Faculty of Engineering Prof. Dr. Raveendran Paramesran 22 2 26 Faculty of Engineering Prof. Dr. Mohamed Kheireddine Taieb Aroua 8 NA 27 Faculty of Engineering Professor Ir. Dr. Wan Abu Bakar Wan Abas 57 2 28 Faculty of Engineering Dr.Kazi Md. Salim Newaz 10 2 29 Faculty of Engineering Dr. Ahmad Badarudin Mohamad Badry 10 2 30 Faculty of Engineering Assoc. Prof. Dr. Lam Wei Haur 20 4 31 Faculty of Engineering Dr. Hazlee Azil Illias 20 1 32 Faculty of Engineering Assoc. Prof. Dr. Faisal Rafiq Mahamd Adikan NA NA 33 Faculty of Dentistry Assoc. Prof. Dr. Chen Yeng 7 1 34 Faculty of Dentistry Prof. Ian Paterson 12 3 35 Faculty of Dentistry Dr. Chew Hooi Pin 5 1 36 Faculty of Dentistry Assoc. Prof. Dr. Roslan Saub 2 1 37 Faculty of Dentistry Dr. Siti Adibah Othman 5 1 38 Faculty of Dentistry Assoc. Prof. Dr. Hadijah Abdullah 8 NA 39 Faculty of Dentistry Assoc. Prof. Dr. Fathilah Abdul Razak 4 NA 40 Faculty of Dentistry Assoc. Prof. Dr. Marina Mohd. Bakri 3 1 75 76 High Impact Research Annual Report 2012 No. Faculty Principal Investigator (PI) Target output No. of Tier 1 ISI-Indexed Publications International Collaborations 41 Faculty of Dentistry Dr Wan Himratul Aznita Binti Wan Harun 3 NA 42 Faculty of Dentistry Dr. Nor Himazian Mohamed 3 NA 43 Faculty of Dentistry Prof Dr Phrabhakaran Nambiar 4 NA 44 Faculty of Dentistry Assoc. Prof. Dr. Chen Yeng 3 NA 45 Faculty of Dentistry Assoc. Prof. Dr. Zamri Radzi 35 1 46 FCSIT Dr. Chan Chee Seng 5 2 47 FCSIT Dr. Rafidah Md Noor 3 2 48 FCSIT Prof. Dr. Loo Chu Kiong 10 4 49 FCSIT Assoc. Prof. Dr. Abrizah Abdullah 3 NA 50 FCSIT Assoc. Prof. Dr. Miss Laiha Mat Kiah 4 NA 51 FCSIT Prof. Dr. Lee Sai Peck 3 NA 52 Faculty of Science Emeritus Profesor Dr. Yong Hoi Sen 11 NA 53 Faculty of Medicine Profesor Dr. Vickneswaran Mathaneswaran 20 1 * FCSIT – Faculty of Computer Science and Information Technology RESEARCH PROPOSALS 2012 • • • • • • HIR 2 years HIR-MoHE (Medicine) HIR-MoHE (Engineering) HIR-MoHE (Dentistry) HIR-MoHE (Computer Science & Information Technology) HIR-MoHE (Chancellory) 78 High Impact Research Annual Report 2012 RESEARCH PROPOSALS (HIR 2 Years) Project No: UM.C/625/1/HIR/130 Title: Large-scale Profiling of Cancer/Testis Antigens (CTA) and the Delineation of MiRNA-mediated Reversal of CTA-associated Aberrant Demethylation in Urothelial Cell Carcinoma Principal Investigator: Assoc. Prof. Ong Teng Aik Department: Surgery Faculty: Medicine Summary of Research Proposal In Malaysia, bladder cancer is the 6th most common cancer amongst males. Among that, over 75% of patients are initially diagnosed with superficial tumours. The 5-year survival rates de-creases with the degree of tumour invasiveness and the presence of metastasis. Cancer/testis antigens (CTAs) are usually restricted to the testis in the normal adult, but are aberrantly expressed in several types of cancers. Because of their restricted expression pattern, the CTAs represent attractive biomarker candidates for cancer diagnosis/prognosis.Apart from building the capacity to profile CTA expression, we are interested in investigating the potential of a specific CTA KDM5B as a therapeutic target. We have previously profiled a cohort of UCC tissues and identified several CTAs to be located in regions of high CNV as well as amongst top dysregulated genes in high risk UCC. The deregulation of KDM5B has already been reported in majority of human cancers.Thus identifying the ‘switch’ that abates the expression of KDM5B would accelerate the development of effective therapies to eradicate entire population of cancer cells including the cancer stem cells or tumourinitiating cells named as microRNA(MiRNA). MiRNAs are small endogenous molecules that play substantial roles in human development and cell lineage decisions. As the fundamental regulator of these physiologically significant cellular processes, aberrant expressions of miRNAs are expected to contribute to the development of various human diseases, including cancer. It is based on evidences that the expression of KDM5B in embryonic stem cells are regulated by microRNAs (miRNAs) and expression of some miRNAs are altered in UCC, that we suggest miRNAs as a potentially potent regulator of KDM5B Objectives 1. To establish CTA protein expression and localisation patterns in UCC tissues of dif-ferent stages, grades, clinical outcomes and ethnic groups. 2. To assess the correlation between individual and/or combination of CTA expression and: • clinical stage and grade (superficial vs muscle invasive disease) • recurrence risk in individuals with superficial disease • disease progression (superficial to invasive disease transition) 3. To identify miRNAs (antagomirs) that target KDM5B in UCC 4. To determine the effect of KDM5B-targeting miRNAs on aberrant histone methyla-tion profiles in UCC, especially in CSC subpopulations High Impact Research Annual Report 2012 Methodology Outcome Current Progress This project aims to consolidate the existing multi-disciplinary local expertise with world-reknowned clinical and scientific academics from University of Cambridge, Johns Hopkins University and University College London to jumpstart bladder cancer research in the region. The project will be a catalyst for future highimpact research projects that will establish Malaysia in the global research map against bladder cancer. Nevertheless, this project will also produce the following expected results and benefits: 1. Ethics approval from UMMC and Ministry of Health 2. Sample collection 3. Optimization of IHC techniques • • CTA profiles are predictive of tumour recurrent and invasive potential and suggesting as prognostic biomarkers for recurrence or progression to invasive disease. Specific miRNAs that abate the expression of oncogenic CTA reverses the abberant histone methylation profiles in bladder cancer stem cells; could be used as a therapeutic antagomir that can act as an adjuvant therapeutic to reduce risk of recurrence. Collaborators Prof Dr Azad Hassan bin Abdul Razack, Dr. Retnagowri Rajandram, Dr. Jasmine Lim, Department of Surgery, University of Malaya, Malaysia. Prof Datuk Dr Looi Lai Meng, Department of Pathology, University of Malaya, Malaysia. Asst Prof Dr Abhimanyu Veerakumarasivam, Perdana University Graduate School of Medicine, Malaysia & Universiti Putra Malaysia. Prof Dr David Neal, Department of Oncology, University of Cambridge, UK Prof Dr John Kelly, Division of Surgery & Interventional Science, UCL Medical School, University College London. Prof Dr Robert H. Getzenberg, James Buchanan Brady Urological Institue, Johns Hopkins University School of Medicine, USA. Assoc. Prof. Dr. Edmund Sim Ui Hang, Department of Molecular Biology, Faculty of Re-source Science & Technology, Universiti Malaysia Sarawak. Dr Murali Sundram, Hospital Kuala Lumpur, Malaysia Dr Teh Guan Chou, Consultant Urologist, Head of Department Department of Urology, Hospital Umum Sarawak. Dr. Jamil Dol Kadir, Consultant Urologist,Head and Senior Consultant Pathologist,Hospital Umum Sarawak. Dr Chan Soon Choy, Perdana University Graduate School of Medicine, Malaysia. 79 80 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/131 Title: Development of Advanced Ceramics Thin Films From Single Source Precursor by AACVD for Solar Cell Technology Principal Investigator: Professor. Dr. Muhammad Mazhar Department: Chemistry Faculty: Science Summary of Research Proposal Advanced ceramics poised of versatile elemental combinations include metal oxides, metal car-bides, and metal nitrides reveal a wide range of properties that have found its way for novel cat-alytic, sensors, structural, electrical, electronic, magnetic, and biomaterials applications. The ceramics thin-film fabricated by using physical techniques suffer from multiple drawbacks such as poor conformality, low throughput, restricted directional variation, and low compositional con-trol. These adverse effects make these thin films less useful for making devices. Therefore, our research features for the fabrication of advanced ceramics thin films through an inexpensive Aerosol Assisted Chemical Vapour Deposition (AACVD) based on single source molecular pre-cursors (SSP) technique that is particularly valuable to fabricate thin films in a single step with controlled stoichiometry, uniformity, morphology and improved optical properties with applica-tions in alternative energy and electronics fields. AACVD technology is a rather recent method to gain favor in the processing of advanced ceramics thin films offering extensive advantages. Objectives The specific objectives of this research project are 1. Designing of specifically tailored novel metal organic precursors. 2. Fabrication of advanced ceramic oxide/ sulphide thin films using new precursors. 3. Investigation of properties of thin films for solar cell applications. Outcome Advanced ceramics thin films fabricated by this work can be employeed in field of electronics, solid oxide fuel cells, photoelectrochemical splitting of water for production of hydrogen and hydrogen storage materials. Possible High Impact Journals for Publications 1. Chemical Vapour Deposition 2. Inorganic Chimica Acta 3. Dalton Transction 4. Thin Solid Films 5. Inorganic Chemistry Collaborators Dr. K.G. Upul Wijayantha, Loughborough University, United Kingdom Dr. Asif Ali Tahir, University of Liverpool, United Kingdom Project No: UM.C/625/HIR/132 Title: A Robust Method For Copy- Forgery Detection In Digital Images. Principal Investigator: Hamid Abdulla Jalab Department: Computer System & Technology Faculty: Computer Science & Information Technology Summary of Research Proposal Tampering the digital images in a way that it’s impossible to be detected by naked eyes has become easier with development of image editing tools. Copy-move forgery is one of the frequently used and important techniques to hide or manipulate the content of the image. It happens by coping one part of the image and pastes it to another part of the same image to cover an important object. Consequently, this research is intended to propose an efficient method for Copy-move forgery detection in digital images using singular value decomposition technique which is able to authenticate the High Impact Research Annual Report 2012 digital image and detect the tamper locations accurately. The authentication method will be worked on gray-scale and RGB images. Finally, implementation of research outcomes proposed by this study can be used as powerful digital image forensic tool to authenticate the digital image along with locating the exact locations of tampers. Objectives Methodology Outcome 1. To investigate on existing Copy-Move forgery detection methods. 2. To implement a new efficient copy-move detection technique with high tamper detection rate 3. To improve the accuracy of the detection rate. Develop a new efficient copymove detection technique with high tamper detection rate, which can be used as powerful digital image forensic tool to authenticate the digital image along with locating the exact locations of tampers. 4. To assess the accuracy of detection percentage of proposed method compared to oth-ers. Requirement analysis phase is the first step of the project which is consists of evaluating the existed technique that we are going to investigate and improve. The comparison between differ-ent techniques of tamper detection will be conducted in Literature review of the project. The proposed detection system works based on Singular value decomposition, it is a valuable meth-od and has been used in a lot of fields such as image processing, image compression, data analysis, signal processing and weather prediction. It presents a suitable way for cutting off a matrix to get useful data about the image, and shows a factorization for all matrices. The pro-posed prototype will be implemented using MATLAB which is a high performance language that consist of variety of tool box. In testing phase of project different attacks will be performed in order to prove the efficiency of proposed copy-move detection system. Possible High Impact Journals for Publications 1. Journal of Computer and System Sciences 2. IEEE Transactions on Computers 3. Journal of Systems and Software 4. Journal SIGNAL PROCESSING 5. Journal of Real-Time Image Processing Collaborators Dr. Ali Elkateeb . Department of Electrical and Computer Engineering at University of Michigan, Dearborn, USA . e-mail: elkateeb@umd.umich.edu Project No: UM.C/625/1/HIR/134 Title: An Integrated Morphological, Evolutionary Genomics and Genome Characterization of Clinical and Economical Significant Dematiaceous Fungi Principal Investigator: Professor Dr. Ng Kee Peng Department: Medical Microbiology Faculty: Medicine Summary of Research Proposal Dematiaceous fungi are typically soil saprophytes, plant pathogens, and contaminants living in the hospital and laboratory environment. They are common indoor allergens causing hay fever or hypersensitivity reactions in susceptible individuals that sometime could lead to acute exacerbation of asthma and cause opportunistic infections in immunocompromised AIDS patients. The current lack of familiarity of dematiaceous infection among the clinicians and lab personnel coupled with inadequate sensitivity and specificity 81 82 High Impact Research Annual Report 2012 tests have contributed to the diffi-culties of clinical isolates identification. This research project is based on the research outputs and novel findings from the first project supported by HIR (UM.C/625/1/HIR/004, Project Title: Cultural and genomics characterization of dematiaceous fungi isolated in Malaysia). The com-plete phenotypic, taxanomic and genome characterization of three fungal genera from the study may lead these isolated strains to become the medical reference strains and genome sequences for all future comparison analysis. Findings from the analysis of these fungal genome sequences will serve as important platform to develop downstream clinical and pharmaceutical applications that is critical in exploiting the utility of fungal traits and improving healthcare management. Objectives Methodology Outcome This research aim to study morphological and evolution genomics of new dematiaceous fungi isolated from the UM’s Mycology Laboratory and generation of 10 draft genome sequenc-es from the isolates. An Integrated Fungal Genome Database and Genome Browser will be de-veloped which served as a platform for accumulation and retainment of knowledge, standardiza-tion of data and; create a platform for local and international collaboration. Lastly, we aim to elucidate the functional complexity of fungal genomes via whole transcriptome sequencing ap-proach. The black molds reference strains to be used in this study will be selected among the 112 dematiaceous fungi isolated in UMMC from previous study. New isolates from the clinical and nonclinical specimens will be included in this study. Increase numbers of previously uncharacterized fungi among different phylogenetic classes for genome sequencing in this study will enhance the knowledge on diversity and conserved traits among the dematiaceous fungus. 1. Generation of draft genomes of dematiaceous fungi 2. Identified genes associated with the virulence and transformation of enviromental saprophytic fungi to fungi associated with human diseases. Possible High Impact Journals for Publications PLos ONE , BMC Genomics, Eukaryotic Cells, Genome Research, Genomics Collaborators Yap Thai Leong (PhD), Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, 208013, USA Project No: UM.C/625/1/HIR/ 136 Title: Investigation of function and transcriptional regulatorymechanism of Runx1 molecule in early B lymphocyte development Principal Investigator: Wong Won Fen Department: Department of Medical Microbiology Faculty: Faculty of Medicine Summary of Research Proposal B lineage lymphocyte development involves series of processes including heavy and light chain VDJ rearrangement, pre-B cell receptor (BCR) formation and selection. Impairment of B cell development can cause B lineage-acute lymphoblastic leukemia (B-ALL) and agammaglobulinemia immunodeficiency disease. One of the main cause for B-ALL is chromosomal translocation t(8,21) which leads to lost-of-function mutation in gene encoding Runx1. Runx1 is a member of Runt family transcription factor that plays an essential role in definitive hematopoiesis and T lymphocyte differentiation. We previously found that the expression level of High Impact Research Annual Report 2012 Runx1 in B lymphocytes is high, implying a potential role for Runx1 in the controlling B cell developmental or functional program. However, at present, the role of Runx1 in regulating B cell development is poorly understood. Objectives In this study, we would like to investigate Runx1’s role in the regulation of early B cell development and immune response. Methodology We will first examine the expression pattern of Runx1 at different developmental stages including pro-, pre-, immature and mature B cells in bone marrow or in spleen. Following this, we will prepare conditional knock out mice with specific deletion of Runx1 in B cells. Propotional changes in the B cells versus other hematopoietic cells in bone marrow, lymphoid organs or in circulation will be measured. Important processes during early B cells development such as VDJ recombination, cell apoptosis and B cell receptor (BCR) formation will be studied intensively between control and Runx1 deficient mice. Finally, we will infect the mice with pathogen such as H1N1 influenza virus and evaluate a potential defect in plasma B cell differentiation and immunoglobulin secretion capability due to lost of Runx1. Possible High Impact Journals for Publications Nature Immunology Collaborators Masanobu Satake, Tohoku University, Japan. Kazuyoshi Kohu, National University of Singapore, Singapore Outcome This study is important for understanding of B cell lineage commitment, which outcome may contribute to a solution for B-ALL or agammaglobulin disease. Project No: UM.C/625/1/HIR/139 Title: Mechanisms of T cell dysfunctions in hepatitis C infection Principal Investigator: Assoc. Prof. Dr Shankar Esaki Muthu Department: Department of Medical Microbiology Faculty: Faculty of Medicine Summary of Research Proposal Hepatitis C virus (HCV) is a positive-sense single-stranded RNA virus that has been estimated to affect ~170 million people worldwide. About 70% of the infected individuals clear the virus spontaneously during the acute phase of infection whereas ~30% of individuals progress to chronic phase that eventually culminates in cirrhosis and hepatocellular carcinoma (HCC). Functional exhaustion/immunosenescence which leading to immune dysfunction of T cells is also the hallmark of other persistent viral infections (PVIs) exemplified by hepatitis B virus (HBV) and HIV infections in human. A number of genes have been found to be upregulated or downregulated in exhausted T cells in HCV, suggesting a role for inhibitory molecules. These molecules reportedly facilitate HCV persistence in the host. Probe, LAG-3, TRAIL, BLIMP-1, FoxP3, PD-1, TIM-3, CTLA-4, and secreted indoleamine 2, 3 dioxygenase (IDO) are some of the most widely investigated inhibitory molecules in PVIs (especially murine LCMV infection) that were identified to be overexpressed in functionally impaired T cells. In the proposed investigation, these various inhibitory molecules/receptors that are potentially associated with immune dysregulation with HCV infection, and the immunopathophysiological mechanisms underlying their upregulation are likely to be addressed. 83 84 High Impact Research Annual Report 2012 Objectives Methodology We aim to investigate the expression of numerous inhibitory and functional molecules up-regulated and/or downregulated in exhausted CD4+ and CD8+ effector and central memory T cells and myeloid dendritic cells of HCV infection. In this sectional, we also aim to investigate the transcriptional cell signaling pathways regulating the expression of inhibitory molecules in T cells that regulate expansion and restoration of HCV-specific T cells during chronic HCV infection. Numerous inhibitory molecules/ receptors that are involved in immune dysregulation in HCV in-fection will be studied to describe the mechanism to get a detailed picture of key regulator of early antiviral responses that determines whether an infection is resolved rapidly progresses to chronic infection. A comprehensive study will be conducted through proteomics approaches with support of available immunological resources and softwares. Final validation will be conducted via molecular approaches to underpin the association of suppressor molecules with HCV-associated immune exhaustion. Outcome Possible High Impact Journals for Publications European Journal of Immunology, Journal of Immunology , Molecular Medicine, PLoS ONE Collaborators Marie Larsson, Linköping Universitet, Sweden. Karlhans Fru Che, Karolinska Institutet, Solna, Stockholm, Sweden. Vijayakumar Velu, Emory University, Atlanta, USA. Shukkur Muhammed Farooq, Wayne State University, USA . Subhadra Nandakumar, Centers For Disease Control, Atlanta, USA. Understanding the precise mechanisms whereby HCV recruits immune regulatory components that lead to progression of chronic HCV would lead to development of novel avenues of transla-tional research to treat or improve the quality of life of HCV infected individuals. Project No: UM.C/625/1/HIR/140 Title: Zircon U-Pb geochronology for sedimentary Provenance, magnetism, and tectonic evolution of Malaysia and adjacent regions Principal Investigator: Associate Professor Dr. Masatoshi Sone Department: Geology Faculty: Science Summary of Research Proposal Today, a 1/4 of all high-impact researches in Geoscience deal more or less with zircon U-Pb geochronology. Zircon is a radioactive mineral that forms principally in cooled magma and can remain as detrital grains over billion years of Earth history. It can indicate fair accurate ages of igneous and metamorphic rocks and can be used for identifying provenance (source) of sedi-mentary rocks. This can be applied to tectonic reconstruction and basin evolution of SE Asia terranes. For example, the core of SE Asia consists of two tectonic blocks, Sibumasu and Indo-china, which have been separated from Gondwana at different times, but their locations in Gondwana are not clearly understood. Zircon geochronology may reveal their origins, and it will help us better understand the tectonic evolution of SE Asia. High Impact Research Annual Report 2012 Objectives 1. 2. 3. Determine the most plausible location of Sibumasu in Gondwana; Determine provenance of SE Asian sedimentary rocks, e.g., Gondwana origin of the Cambrian Machinchang Formation in Langkawi Geopark, and linkage of Mesozoic fluvial sediment between Indochina and Malaysia; Tectonostratigraphic correlation among different terrains in SE Asia. to collect data for U-Pb ages and Hf isotope. The data will be analysed to determine zircon age populations and modes and Hf affinity for crustal and mantle sources. The results will be compared with other parts of Asia-Australia to confirm if there are any similarities and/or dissimilarities in zircon properties. Other sedimentological, geochemical and petrological analyses will be carried out in UM. Outcome 1. Gondwana origin of SE Asian terranes; Methodology 2. Samples of sedimentary, igneous and metamorphic rocks will be collected from targeted formations of SE Asia. Zircon grains will first be separated at Academia Sinica, Beijing. Then, the zircon will be examined at LA-ICP-MS lab of National Taiwan University Provenance linkage of sedimentary rocks between Indochina and Malaysia (e.g. the Tembeling Group in Taman Negara); 3. Late PalaeozoicMesozoic stratigraphy, palaeogeography and tectonic evolution of SE Asia Possible High Impact Journals for Publications Geology; Gondwana Research; Journal of Asian Earth Sciences; International Journal of Earth Sciences Collaborators Sun-Lin Chung, Hao-Yang Lee (National Taiwan University); Mike Searle (Oxford); Satoshi Tanaka (Kyoto University of Education); Toshifumi Komatsu (Kumamoto Univer-sity); Kamal Shuib, Azman Abdul Ghani (UM) Project No: UM.C/625/1/HIR/141 Title: Experimental and Numerical Investigation on Tsunami Acting On Cable Stayed Bridges Principal Investigator: Associate Prof. Dr. Zubaidah Binti Ismail Department: Civil Engineering Faculty: Engineering Summary of Research Proposal Two tragic tsunamis that devastated the west coast of Sumatra Island, Indonesia in 2004 and North East Japan in 2011 had damaged bridges to various extents. Due to the increasing popularity of cable stayed bridges, it is vital that more attention be paid to the effects of tsunamis on this type of bridge. In order to understand the tsunami force on cable stayed bridges, experimental tests will be carried out to study the characteristics of hydrodynamic force at different wave heights. The fluid structure interaction between the cable stayed bridge and tsunami for numerical model based on finite element analysis by LS-DYNA will be conducted. Numerical models of tsunami impact on the bridge superstructures will be developed. Objectives The objectives of this research can be summarized as follows: 1. Identify mechanism of wave propagation around cable stayed bridge; 2. Evaluate the physical phenomena of tsunami force on cable and deck of cable stayed bridge; 3. Conduct experimental tests to determine the distribution of hydrodynamic, impulsive, buoyant and uplift forces on cable stayed bridge due to tsunami; and 4. Validate the experimental analysis by simulating using numerical and computation anal-ysis. 85 86 High Impact Research Annual Report 2012 Methodology This study includes experimental study in National Hydraulic Research Institute of Malaysia and Hydraulic Laboratory of University of Malaya and also computational and numerical modelling for validation purposes. The second Penang Bridge will be modelled on 1:100 scale in a 40m long hydraulic flume with a cross section of 1.25m by 1m. The model dimension is 47cm long, 30cm wide and 10cm high. A high frequency load cell with 6 degrees of freedom will be mounted at the base of the model to record the tsunami forces. A bi-linear pressure profile is proposed for determining the maximum tsunami force acting on the model. An accelerometer is installed at the top of the bridge model with the purpose of estimating the time history of the bridge’s acceleration. A numerical model based on finite element code by LS-DYNA will be used to simulate the laboratory model subject to hydrodynamic loads of tsunami to estimate load and tension distribution of the bridge model Possible High Impact Journals for Publications 1. Journal of Engineering Structures 2. Journal of Coastal Engineering 3. Journal of Hydraulic Engineering Outcome Numerical and experimental study of tsunami wave loading on a cable stayed bridge can produce valuable understanding on characteristics of wave loading and identified mechanism of wave propagation and tsunami load distribution around the bridge superstructure. There are many gaps in the studies on tsunami wave on bridge superstructure and this proposal aims to improve the understanding of the characteristics of tsunami on bridge superstructures. Collaborators Professor Dr. Hashim Abdul Razak, Department of Civil Engineering, Faculty of Engineering, University of Malaya, Malaysia Dr Zainah Ibrahim, Department of Civil Engineering, Faculty of Engineering, University of Malaya, Malaysia. Professor Dr. Yozo FUJINO, Department of Civil Engineering, University of Tokyo, Ja-pan Project No: UM.C/625/1/HIR/148/2 Title: Elucidation of the mechanism and rescue of the Human Neural Tube Defects gene(s) Principal Investigator: Dr. Noraishah Mydin Abdul Aziz Department: Parasitology Faculty: Medicine Summary of Research Proposal We have constructed the EphA2 EphA4 double heterozygotes which exhibits 38% spina bifida and 6% exencephaly. We are currently using the EphA2 EphA4 double heterozygotes embryos to further understand the role of ultrastructures. Electron microscopy studies on these embryos have shown an explosion of apoptotic cells on the surface of the unfused neural tube. Rescue experiments using the black seed oil is also currently underway using the EphA2 EphA4 double heterozygotes as models. Furthermore, we have identified 2 potential NTD causative genes in the human spina bifida population via exome analysis. Objectives 1. To assess the possibility that EphA2 and EphA4 may be candidates for human neural tube defects. 2. To identify other potential variant genes causing Spina bifida in Malaysian population. 3. To investigate the activities of BSO on the NTDs in EphA2 and EphA4 compound mu-tants and compound heterozygotes 4. To rescue MEKK4 using BSO 5. To assess the possibility that BSO may be a candidate for a new preventive NTDs supplement alongside folate and inositol in humans. High Impact Research Annual Report 2012 Methodology 1. Case Selection 2. Gene expression analysis of the EphA2 and EphA4 genes in human Neural tube defect cases 3. Identification of causal genes in humans with neural tube defects 4. Rescue experiments with black seed oil (BSO), Mice, food preparation, feeding and measurement on MEKK4 5. Generation and dissection of homozygous embryos by crossing the heterozygous mice, Analysis of progeny 6. TUNEL Assays, Cell Proliferation Assay (BrdU Analysis) 7. Preservation and Analysis of ultra-structure at posterior and anterior neuropore of the spinal neural tube using electron microscopy 8. Adhesion and fusion of spinal neural folds occur asymmetrically and are mediated by EphA2 and EphA4 receptor tyrosine kinase – Nature (To be submitted December 2013) 9. 3. Maternal intake of dietary virgin coconut oil modifies fatty acids causing low birth weight and spiky fur in mice – PloS Medicine (To be submitted June 2013) 10. Gastrochisis in the EphA2/EphA4 compound heterozygotes due to failure of adhesion and fusion – PloS One (To be submitted June 2014) 4. Consequences of nutritional oils during pregnancy – what is safe and what is not ? – Na-ture Medicine (To be submitted December 2013) 5. 6. Molecular study Outcome Possible High Impact Journals for Publications 1. 2. Pai YJ, Abdullah NL, Mohd.Zin SW, Mohammed RS, Rolo A, Greene ND, AbdulAziz NM, Copp AJ. Epithelial Fusion during Neural Tube Morphogenesis (2012). Birth Defects Res A Clin Mol Teratol. 2012 Oct;94(10):81723. doi: 10.1002/bdra.23072. Epub 2012 Sep 3. Essential fatty acids profile of black seed oil from Yemen show marked differences in comparison to black seed oil from other regions of the world – TALANTA (submitted No-vember 2012) Black Seed Oil rescues Folate and Inositol-Resistant Neural Tube Defects – Nature (To be submitted December 2014) 7. Essential fatty acids of black seed oil is neurulationspecific and promotes neural tube closure – Proceedings of the National Academy of Sciences USA (To be submitted De-cember 2013) 8. Exome sequencing and functional analysis identifies human EPHA2 and EPHA4 as the cause of neural tube defects - Proceedings of the National Academy of Sciences USA (To be submitted December 2014) Targeted capture and massively parallel sequencing of 3 triad family exomes of non syndromic Neural Tube Defects – PloS One (To be submitted December 2014) Collaborators Dr Azlina Ahmad-Annuar, Faculty of Medicine, UM. Prof Thong Meow Keong, Faculty of Medicine, UM. Assoc Prof Mary Joseph Marret, Faculty of Medicine, UM. Dr Julia Patrick Engkasan, Faculty of Medicine, UM. Dato’ Prof. Dr. Zaliha Omar Prof. Dr. Aminah Abdullah Dr Nicholas Daniel Edward Greene, Neural Development Unit, Institute of Child Health, University College London 87 88 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/149 Title: Quantum chromodynamics jet studies at the CERNLarge Hadron Collider (LHC) Principal Investigator : Prof Dr. Wan Ahmad Tajuddin Wan Abdullah Department: Physics Faculty: Science Summary of Research Proposal The Quantum Chromodynamics (QCD) is well understood theoretically and experimentally in hard processes (involving high momenta), there lacks undertanding for soft processes, where perturbative desciptions are not reliable. One manifestion of QCD are particle jets produced in high energy collisions, where intrajet dynamics would especially reflect the soft processes involved. Studying this dynamics would yield understanding of soft QCD and thus would strengthen the whole understanding of QCD itself. Of interest are the question of the production of baryon and multiquark states, and the effect of heavy quarks. Objectives Methodology Outcome The objectives are to develop substructure and exclusive analysis techniques for jets, so as to enhance understanding of jet content, to study production of baryons and other multiquark states in jets, to study heavy hadron production in jets and to study jet differences from different partons. The Large Hadron Collider (LHC) at CERN, Geneva, Switzerland is currently the highest energy hadron collider on earth, colliding protons at energies of 7 TeV. The CMS collaboration handles the CMS detector. Different kinds of analyses have been carried out, including famously the search for the Higgs boson, as well as for other new phenomenolgy like supersymmetry and extra dimensions. Studies of jet physics would involve the analysis of data of collison events containing jets. For the respective objectives given above, the approach to be taken can be: 1. Measurement of Inelastic J/ psi and psi’ Photoproduction at HERA DESY-12-226 (November 2012) to be published in JHEP 2. Combination and QCD Analysis of Charm Production Cross Section Measurements in DeepInelastic ep Scattering at HERA DESY-12-172 (November 2012) to be published in Eur. Phys. J. C 3. Production of Z^0 bosons in elastic and quasi-elastic ep collisions at HERA DESY12-168 (October 2012) published in Phys. Lett. B 718 (2013) 915-921 1. For substructure, look recursively for subjets and subsubjets etc., by boosting to the jet rest frame. It would also be interesting to reconstruct jets exclusively bottom-up using decay channel information, particle identification, and probabilistic analysis. 2. Baryons and other multiquark states can be identified by reconstructing their decays. 3. Heavy quark content can be identified through their decay channels and deca reconstruction. 4. Origin of jets can be identified e.g. through tagging via ‘other’ particles (e.g. thorugh leptonic decays, long lifetimes, etc). Topology, etc of jets of different origins can be compared. Possible High Impact Journals for Publications 1. Physics Letter B 2. Journal of High Energy Physics 3. Journal of Physics GNuclear and Particle Physic Collaborators CMS Collaboration (1740 scientists from 179 institutions from 41 countries) & ZEUS High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/150 Title: The Development of Islamic Project Management Framework (IPMF) of Construction and Development Industry Principal Investigator: Prof. Dr. Hamzah Abdul Rahman Department: Department of Quantity Surveying Summary of Research Proposal: A wide range of standards methodologies, guide and frameworks is currently available for project management (e.g. ISO, ANSI. Due to this diversity, the selection and application of PM approaches is a complex problem for organizations. The challenge is to identify an approach that is widely used among project partners and stakeholders so that a consensus can be established, is applicable for this type of organization and the type of projects so that it can be implemented efficiently and unfolds real benefits for the organization so that it is effective. Up to now, little research has been carried out into the Islamic perspectives and values of project management. Due to Malaysian culture, the role of Islamic values in business and to meet the local need in this study a framework for Islamic Project management of construction and development industry will be developed to be a basis for construction and development industry in order to fulfill the need and knowledge gap in this area and to have a project management approach roots in Islamic values. Objectives Methodology To develop an improved model from the conventional project management approaches which is currently being applied in construction industry and to develop a practical framework for project management in construction and development industry based on the improved model and Is-lamic values. Development of practical Islamic Project Management Framework (IPMF) of Construction and Development Industry will be developed to be a basis for construction and development industry in order to fulfill the need and knowledge gap in this area and to have a project management approach roots in Islamic values.A comprehensive and exploratory study will be conducted through current Project Management approaches to identify current problem and deficiencies associated with them and to Identify the major problem in construction industry. After the gap has been identified a new framework comprises of Islamic Values to supplement existing framework will be developed based on most reliable islamic resources( Al-Quran) and islamic Scholars. Outcome Development of practical Islamic Project Management Framework (IPMF) of Construction and Development Industry to be a basis for construction and development industry in order to fulfill the need and knowledge gap in this area and to have a project management approach roots in Islamic values. Possible High Impact Journals for Publications 1. Journal of civil engineering and management 2. Building research and information 3. Automation in construction 4. International journal of project management 5. journal of construction engineering and management-asce Collaborators Dr. Zulkifli Hj. Mohd Yusoff, Academy of Islam, Universiti Malaya Dr. Wang Chen, Department of Quantity Surveying, Faculty of Built Environment, Uni-versiti Malaya, Dr. Abdul Aziz Abdullah, Faculty Of Business Management and Accountancy, University Of Sultan Zainal Abidin 89 90 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/151 Title: 14-Membered Macrocyclic Systems Dibenzotetraaza[14]annulenes as Ligands for Metal Ions and Hosts for Fullerenes Principal Investigator: Prof Hapipah Mohd Ali Department: Chemistry Faculty: Faculty of Science Summary of Research Proposal Dibenzotetraaza[14]annulenes are a class of synthetic macrocyclic compounds which have at-tracted a great deal of continued interest because of their resemblance to the naturally occurring porphyrins, thus their relevance in bioinorganic chemistry. Moreover, due to the extended π system of dibenzotetraaza[14]annulenes, they have been studied for their ability to cocrystallize with fullerenes. In this study we introduce a new class of dibenzotetraaza[14]annulenes, having indolenine moieties, as ligands for transition metal ions. The cocrystallization behavior of the synthesized macrocycles with fullerenes will be studied. Use of 2-(diformylmethylidene)3,3-dimethylindole inserts two conjugated arms on the macrocycles, thus promotes the cocrystalli-zation with fullerenes. Objectives Methodology Outcome Preparation of new Dibenzotetraaza[14]annulenes (indolenine-base), study the coordination behavior of the indolenine-based dibenzotetraaza[14]annulenes towards transition metal ions and to study their cocrystallization behavior with Fullerenes Dibenzotetraaza[14]annulenes will be prepared by the 2:2 condensation of substituated o-phenylene diamines with 2-(diformylmethylene)-3,3dimethylindole. The metal complexation will be done by reacting the macrocycles with the metal salt in the presence of a tertiary amine base. The metal in principle can be coordinated by the central nitrogen atoms or the indolenine nitrogen atoms. Introducing a novel macrocyclic system for metal coordination chemistry and host-guest cocrys-tallization studies. The products are expected to be good candidates for sensors (light humidity and temperature sensors). The cocrystallization of the macrocycles with fullerene will be carried out in CS2, Benzylchloride, Chlorobenzene and CHCl3. Crystal structures will be analyzed by X-ray crystallography. Diffraction data will be measured using a Bruker APEX II CCD area-detector diffractometer. The orientation matrix, unit cell refinement and data reduction will be all handled by the APEX II software (SAINT integration, SADABS absorption correction). Possible High Impact Journals for Publications 1. Inorganic Chemistry (Q1, Impact Factor: 4.601) 2. Dalton Transactions (Q1, Impact Factor: 3.838) Collaborators Professor Marilyn M. Olstead, University of California, Davis, USA High Impact Research Annual Report 2012 RESEARCH PROPOSAL (HIR-MoHE 4 Years) Faculty of Medicine Project No: UM.C/HIR/MOHE/MED/18 Title: Identification and Genotyping of Medically Important Parasites and Mosquitoes Sub-Project 1: Identification, Cloning, Expression, and Characterization of the Gene for Plasmodium falciparum and Plasmodium vivax Surface Proteins in Isolates from Low and High Malaria Transmission Areas Sub-Project 2: Genotypic Characteristics of Toxoplasma gondii Strains from Human and Feline animals Sub-Project 3: Molecular Characterization of Opportunistic Pathogens Sub-Project 4: Identification and Genotyping of Medically Mosquitoes Principal Investigator: Dr. Lau Yee Ling Sub-Project 1: Professor Madya Dr. Hesham Mahyoub Sarhan Al-Mekhlafi Sub-Project 2: Professor Madya Dr. Veeranoot Nissapatorn Sub-Project 3: Professor Dr Rohela Mahmud Sub-Project 4: Dr Lau Yee Ling Department: Parasitology S-P 1 S-P 2 S-P 3 S-P 4 Summary of Research Proposal Sub-Project 1: Malaria is the most important vector-borne parasitic disease in the world in terms of morbidity and mortality. Our study is aimed to identify and clone the Plasmodium surface proteins, to ex-press, purify and characterize recombinant TRAMP using phage display library and to investi-gate the naturally acquired cellular immunity to PlasmodiumTRAMP for future trials of TRAP-based vaccines in patients from low and high malaria transmission areas. Sub-Project 2: Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, infecting warm blood ani-mals included man. Different clonal lineages of T. gondii result in very different outcomes. It is important to determine the lineage types of T. gondii associated with human toxoplasmosis. This project aims to determine the association between Toxoplasma seropositivity and typing strains in these patients and thus develop a Loop-mediated isothermal amplification (LAMP) test for toxoplasmosis in these patients. Sub-Project 3: Opportunistic parasitic infections caused by Cryptosporidium, microsporidia, Entamoeba and Acanthamoeba are important causes of morbidity and mortality especially in immunocompromised individuals. In the present study, we will genetically characterize Cryptosporidium, micro-sporidia, Entamoeba and Acanthamoeba from a diverse cohorts of immunocompromised pa-tients in Malaysia. Sub-Project 4: With the changes in ecological environment and with the loss of biodiversity, the distribution of vector mosquitoes have also changed. Control strategies have also led to the eradication of some vectors and their habitat may now be occupied by other species. Thus it is important to study the distribution of these vectors. 91 92 High Impact Research Annual Report 2012 Objectives Identification and characterization of pathogenic parasites and medically important mosquitoes in Malaysia Methodology Sub-Project 1: Blood samples will be collected through active case detection and passive case detection sur-veys. Moreover, archive positive slides will be collected form malaria control units and health centers. PCR amplification, cloning and protein expression will be done for the positive samples. Anti-PfSPATR and PvSPATR antibodies will be generated. An indirect immunofluorescence assay will be used to detect the expression of PfSPATR and PvSPATR protein in sporozoite and erythrocytic stages of P. falciparum and P. vivax parasite. Sub-Project 2: Toxoplasmosis will be screened for the collected blood samples for specific IgM and IgG anti-bodies. Molecular study on genotyping strains of Toxoplasma gondii will be carried out and LAMP test will be developed. Sub-Project 3: Faecal and tissue samples will be taken from immunocompromised patients and will be screen using conventional method for intestinal opportunistic parasites such as Entamoeba, Cryptosporidium and microsporidia while Acanthamoeba will be isolated from tissue samples after a cultivation process. Once isolated, genomic DNA will be extracted from the positive samples and the parasites’ genetic composition will be analysed using real-time PCR targeting multi locus. Amplicons obtained will be sequenced and subsequently analysed using computational software. Sub-Project 4: The mosquitoes species chosen for this study will be the vectors of dengue and filarial. Chosen mosquitoes species in different ecological settings in Peninsular Malaysia, Sabah and Sarawak will be sampled. The mitochondrial cytochrome oxidase c subunit I (COI) and nuclear ribosomal internal transcribed spacer 2 (ITS2) of the chosen species will be sequenced and analysed. Outcome Sub-Project 1: Findings on important surface proteins of P. falciparum and P. vivax as the potential malaria vaccine candidates Sub-Project 2: New therapeutic agents relating to Toxoplasma strains susceptibility in treating human toxo-plasmosis Sub-Project 3: Genetic characterisation of Malaysian isolates of opportunistic parasites Sub-Project 4: This study will provide the first CO1 barcode for Malaysian mosquitoes Possible High Impact Journals for Publications 1. Malarial Journal 2. PLoS One 3. Journal of Clinical Microbiology 4. American Journal of Tropical Medicine and Hygiene 5. Emerging Infectious Diseases Collaborators Dr. Laurent Renia, Laboratory of Malaria, Singapore Immunology Network, A*Star Dr. Bruce Russell, Laboratory of Malaria, Singapore Immunology Network, A*Star Project No: UM.C/625/1/HIR/MOHE/MED/19 - Sub Project 1 Title: Inter-racial comparison of risk factors in ROP Progression in a multi-racial South East Asian community and Identifying the predictive values of growth factors in the development of retinopathy of prematurity (ROP). Principal Investigator: Dr Tengku Ain Kamalden Department: Ophthalmology Summary of Research Proposal Retinopathy of prematurity or ROP is a visually disabling and sightthreatening disease affecting babies born prematurely. Recent advances in neonatal care have resulted in the survival of very low birth weight babies, from as low as 500gm, which is comparable to developed countries. With low birth weights being a major risk factor for developing retinopathy, the High Impact Research Annual Report 2012 rate of ROP is sharply increasing. This disease is treatable with a potentially good visual outcome if diagnosed and treated early. Identification of predictive markers is therefore imperative in distinguishing cases that would require early and aggressive treatment. Objectives Methodology Outcome 1. Blood samples (minimum of 0.7ml) from mothers and babies born with a birth weight of less than 1500gm will be collected and subjected to protein analysis using Western blotting techniques and protein assays, and genetic analysis using Gene sequencing, quantitative and qualitative polymerase chain reaction. Other relevant information such as demographic data, ante-, pre- and postnatal conditions, as well as maternal co-morbidities will be analysed as risk factors. Comparisons will be made among babies from different race groups, as well as with babies born weighing more than 1500gm. The laboratory findings will be correlated to clinical findings during routine fundus examination and recorded on retinal camera. Babies will be followed-up to assess for the progression of disease. Better understanding of the risk factors of retinopathy of prematurity, and determining the 2. To compare the risk factors and genetic predisposition for the development and progression of retinopathy of prematurity among the major ethnic groups in a South Asian community. To identify the role of selected growth factors in premature babies in predicting the development of retinopathy of prematurity with a potential for screening purposes. genetic susceptibility among the different ethnic groups. Possible High Impact Journals for Publications Ophthalmology, Graeves Archives of Ophthalmology, Investigative Journal of Visual Sciences, British Jounral of Ophthalmology Collaborators John Radcliffe Hospital/University of Oxford (CK Patel), Johns Hopkins School of Medicine, USA (Samarjit Das), Cyberjaya Medical School (Solihin Salleh), Paediatric Department, UMMC (CT Lim), Universiti Sains Malaysia (Rozieyati Md Salleh) Project No: UM.C/JIR/MOHE/MED/19 – Sub Project 2 Title: Central and peripheral corneal thickness changes in the normal pregnancy and menstrual cycle and correlation of serum levels of estrogen and progesterone with corneal thickness the relationship of DHEA’s,oestrogen and testerone evels with ARMD: Evaluation of changes after corneal cross linkage Principal Investigator: Professor Dr Visvaraja Subrayan. Faculty: Medicine Brief Summary of Research Progress We have collected 201 patients for the ARMD study and another 98 patients for the normal pregnancy study. For the cross linkage study we are awaiting for the crosslinkage and Ocular response analyser. The tendering process has gone through and the machines are supposed to be delivered in January 2013. Dr Dona Sonali has been employed as a research assistant. Her main function is to collect patients and keep record of the data. From the patient in our system we have done a brief study and published a paper in CORNEA which is a tier 2 journal. 93 94 High Impact Research Annual Report 2012 Outcome Collaborators 1. Central Corneal Thickness Measurements With Different Imaging Devices and Ultrasound Pachymetry. Local: Associate Professor Dr Sushil Vasudevan, UiTM 2. Tai LY, Khaw KW, Ng CM, Subrayan V. Cornea. 2012 Oct 23. [Epub ahead of print] International: Van C. Lansingh MD, PhD Regional IAPB/VISION 2020 Latin America Coordinator Voluntary Assistant Professor of Ophthalmology Miller School of Medicine, University of Miami Professor Dr Baljean Dhillon University of Edinburgh Project No: UM.C/HIR/MOHE/MED/19 – Sub project 3 Title: Serum Levels of Vascular Endothelial Growth Factor, Homocysteine and Interleukin-6 in Correlation with Retinal Vessels Caliber in Patients with Diabetic Retinopathy Principal Investigator: A/Prof Tajunisah Begam Binti Mohamed Iqbal Department: Ophthalmology Summary of Research Proposal: It has been shown that increased serum levels of VEGF may act as a key regulator of Diabetic Retinopathy (DR) and provide a potential tool for risk assessment in diabetic patients. The involvement of VEGF in pathogenesis of diabetic retinopathy is well established, but there is lack of data regarding correlation of this value with retinal vessels diameter. Furthermore, retinal vascular calibre measurement using adaptive optics is highly sensitive method of visualization and monitoring of early signs of diabetic retinopathy. This correlation may clarify the role of non-invasive method of image processing to predict the progress or find the severity of retinopathy. Objectives: Methodology: Outcome To correlate serum levels of Vascular Endothelial Growth Factor, Homocysteine, Interleukin-6 and renal function with Retinal Vessels Caliber in Patients with Diabetic Retinopathy Samples: 70 patients include 35 patients with DR as case and 35 patients as controls. Better understanding of serum cytokines effect on pathogenesis of diabetic retinopathy and to find a molecular link between diabetic retinopathy and nephropathy and correlation with cytokines levels, also to find the role of the retinal microcirculation and retinal vessels diameter in diabetic nephropathy. Levels of VEGF and IL-6 will be determined by ELISA method using specific kits. Homocystein levels will be measured using Immunoturbidimetry assay. Furthermore,we are measuring themicroalbuminuria, renal and lipid profile, HbA1c and fasting blood sugar. Fundus photographs of acceptable quality will take and retinal vascular caliber will be measured using a computerbased program (IVAN, University of Wisconsin). High Impact Research Annual Report 2012 Possible High Impact Journals for Publications: 1. Ophthalmology, 2. IOVS, 3. Microcirculation, 4. Diabetes, 5. Archives of Ophthalmology Collaborators University of Wisconsin – Madison School of Engineering and the Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin – Madison Project No: UM.C/HIR/MOHE/MED/19 – Sub project 4 Title: Animal model for determining dose of intravitreal antibiotics that can cause retinal toxicity Principal Investigator: Associate Professor Kenneth Fong Choong Sian Department: Ophthalmology, Faculty of Medicine, UM Summary of Research Proposal Endophthalmitis is a devastating complication of ocular surgery and intravitreal antibiotics are the mainstay of treatment. The optimal dose is unknown and current doses used may actually be toxic to the retina which impairs visual recovery. Using a mouse eye model, we will inject various doses of newer intravitreal antibiotics into the mouse eye and look for signs of retinal toxicity with electron microscopy and ganglion cell analysis. We have already developed such an experimental model in collaboration with Prof Murali in the Dept of Anatomy, University of Malaya. Objectives Methodology Outcome To determine (1) whether intravitreal moxifloxacin and besifloxacin causes retinal toxicity (2) at which concentrations do these anbiotics cause retinal damage, and (3) at which level of the retina is the damage most prominent. Animal rat models will be given increasing doses of intravitreal moxifloxacin and besifloxacin. Subsequently the function of the retina shall be measured using electroretinography (ERG). The anatomical damage shall be analysed using Retrograde Labelling and Quantification of Retinal Ganglion Cells (RGC) where a dye will be injected into the brain to label the retinal ganglion cells which are visualized on a flatmounted retina using fluorescence microscope. Cross sections of the retina shall be analyzed for retinal thickness as well as for immunohistostaining to determine the extend of retinal damage on the different layers of the retina. Better understanding of the effect of intravitreal antibiotics on the retinal function and anatomy. This can be used as a safe guide to use of intravitreal antibiotics in endophthalmitis. Possible High Impact Journals for Publications Eye, Ophthalmology, British Journal of Opthalmology Collaborators Anatomy Department, UM (Prof Murali), University of ITM (UiTM) (Dr Nurasyikin Mustapha 95 96 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/MED/20 Title: Endothelial dysfunction in dengue haemorrhagic fever Principal Investigator: Prof. Dr. Shamala Devi Sekaran Department: Department of Medical Microbiology- Faculty of Medicine Summary of Research Proposal Dengue hemorrhagic fever (DHF) is characterized by fever, bleeding, and pleural effusion which may be caused by increased vascular permeability. The endothelium is a crucial homeostatic organ essential for normal body functioning, responding to various stimuli and maintaining nor-mal blood flow. Various mediators are released, signals conducted and response effected. Hence dysfunction many result in imbalances between vasodilating and vasoconstricting states. Hence it is assumed that endothelial dysfunction plays a role in the pathogenesis of DHF. The current project proposes to investigate the numerous functions of the endothelium at the molec-ular level systematically. Objectives Methodology To investigate endothelial dysfunction in dengue haemorrhagic fever which lead to vascular leakage at the molecular level. Basically, patient recruitment and sampling will be carried out standard procedures. Various endothelial cell lines will be stimulated under various conditions and mediators (measured by ELISAs kits, Flow Cytometry, Fluorescence microscopy and Western blots. Endothelial function and Endothelial cell markers assessed in vitro and the signaling pathways determined by western blots. Animal models will be utilized for assessment in vivo and validity and efficacy of drugs developed assessed in vitro and in vivo. Outcome Better understanding and knowledge into the risk factors associated with vascular leakage Possible High Impact Journals for Publications 1. PLOS journals, Lancet Infectious Diseases 2. Clinical Infectious Diseases 3. PNAS 4. PLOS Medicine Collaborators PUGSOM (Asif Khan, Steve Dumler), John Hopkins USA (Dennis Grab, JT August), University of South Florida (Azizan Azliyati), UiTM (Wang SM), UMMC (Rishya Manikam, Sasheela, Santha Kumari), UM (Ong KC, Zandi K, Malhoot, A Rathakrishnan, Yeo SL, P Rajendran, Tang YQ, Lee SH, Le CF), Biovalence (Huan UE) High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/MED/22 Title: Mechanisms of cardiovascular therapeutic potentials of boldine and nitrite in animal models of diabetes mellitus and hypertension Principal Investigator: Prof Dr. Mohd Rais Mustafa Department :Centre of Natural Products and Drug Discovery, Deparment of Pharmacology Summary of Research Proposal Hypertension and diabetes mellitus affects health of millions of people worldwide and are major risk factors for cardiovascular disease (CVD), the number one killer globally. Cardiovascular complications are characterized by endothelial dysfunction. There are increased evidences demonstrating excessive oxidative stresses associated with the increased production of super-oxide may account for the endothelial dysfunction in the early stage of these diseases. It is worth noting that the use of antioxidant has been implicated for the past few decades for its therapeutic potential to combat the adverse effect raised by oxidative stress. The present research sought to explore and study the therapeutic potential of an boldine and nitrite as antioxidants in preventing such cardiovascular complications. Objectives Methodology The present research aims to investigate the role of ROS on endothelium-dependent and -independent relaxation in the isolated mouse/rat aorta from diabetic and hypertensive animal models. The exact cause for the ROS generation and the correlation with the use of boldine in the vascular wall of diabetic and hypertensive mouse/rat aortas remains unclear. Therefore, this study also investigates the underlying molecular mechanism and signal transduction pathway involved in the development of endothelial dysfunction induced by oxidative stress and the po-tential novel target by which boldine/ nitrite may mediate their beneficial effects on endothelial function. The diabetic and hypertensive rats /mice acutely treated with nitrite and chronically treated with boldine and the aortas will be obtained by the end of each treatment to assess the time- and dose-dependent improvement in acetylcholine-induced relaxations. The vascular benefit of boldine will also be correlated with alterations in several aspects including: intracellular ROS level and oxidative stress markers. Outcome The novel finding will be provided a new sight on the mechanism for therapeutic potential of boldine/ nitrite in preventing cardiovascular complications in hypertension and diabetes mellitus. Possible High Impact Journals for Publications Biochemical Pharmacology, British Journal of Pharmacology, Cardiovascular Research Collaborators Dr. Dharmani Devi Murugan (University of Malaya); Prof Huang Yu and Dr Tian Xiao Yu ( Chi-nese University of Hong Kong) and Dr. Ajay Machha ( oregan State University, USA). 97 98 High Impact Research Annual Report 2012 RESEARCH PROPOSAL (HIR-MoHE 5 Years) Faculty of Engineering Project No: UM.C/625/1/HIR/MOHE/ENG/24 Title: Applications of Solar Energy In Agricultural Sector Principal Investigator: Prof. Dr. Saad Mekhilef Department: Dept. of Electrical Engineering, Faculty ofEngineering Summary of Research Proposal Solar energy can be used in agriculture in a number of ways, saving money, increasing self-reliance, and reducing pollution. Solar energy can cut a farm’s electricity and heating bills. Solar heat collectors can be used to dry crops and warm homes, livestock buildings, and greenhouses. Solar water heaters can provide hot water for diary operations, pen cleaning, and homes. Photovoltaic (solar electric panels) can power farm operations and remote water pumps, lights, and electric fences. Building and barns can be renovated to capture natural day light, instead of using electric light, solar power is often less expensive than extensive power lines, making the farm more economical and efficient. Objectives General Objectives: 1. 2. 3. 4. 5. To extract energy from natural re-source such as the sun, wind, water. To utilize the extracted energy in a usable form for agricultural application such as heating, lighting etc. To develop mew algorithm and tech-nologies for future expansion in agri-cultural sector. To design electrical instruments and equipments for increasing productivity in agriculture. To provide link between area 1 and area 2. Technical Objectives: 6. 7. 8. To investigate multilevel inverter to-pology for fast and reliable control methods. To improve existing Maximum Power Point Tracker (MPPT) protocol to achieve maximum output. To design switching scheme for multi-level dc-dc converter for voltage conversion. 9. To implement energy storage and dis-tribution system from wind turbine and PV cell. 10. To incorporate power and chemical engineering for interlinking agricultural electrochemical systems. 3. Energy storage and distribution system using efficient PV cell 4. Energy saving by implementing DC-DC converter with LED systems Possible High Impact Journals for Publications Methodology 1. Phase 1: Data collection and field work IEEE transaction on industrial electronics 2. Renewable and sustainable energy review 3. Journal of power electronics 4. IEEE transaction on power electronics 5. IET transaction on power electronics 6. Energy 7. Applied energy 8. Solar energy Phase 2: Chemical equipment preparation Phase 3: Design of electrical equipments Phase 4: Interconnection between energy source and agricultural application Phase 5: Campaign, awareness, seminars and publication Outcome 1. New algorithm and control strategy for multilevel inverter 2. Efficient energy transfer protocol using MPPT (maximum power point tracker) Collaborators Prof. Mutsuo Nakaoka, Dept. of Electrical and Computer Engineering, Yamaguchi University, Japan. Prof. Hong-Tzer Yang, National Cheng Kung University, Taiwan High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/25 Title: Development of an advanced model and optimal control system for gas-phase olefin polymerization in Fluidized-Bed Catalytic Reactor Principal Investigator: Prof. Ir. Dr. Mohd Azlan Hussain Department: Department of Chemical Engineering Summary of Research Proposal: Modeling and control of polymerization process in fluidized bed reactors as one of the most widely used processes for polyolefin production are challenging issues facing industries. This is mainly because of the high non-linearity of the process dynamics due to the complicated reac-tion mechanisms, complex flow characteristics of gas and solids. In this study, a detailed and easily to understand CFD model will be developed for industrial fluidized bed catalytic olefin reactor. Outcome of this study will bring a significant solution to overcome the challenge for scaling up the reactor design through advanced CFD approach. On the other hand, due to process dynamic nonlinearities and difficulties involved in the control of the gas phase olefin polymerization fluidized bed reactor, an efficient process control scheme need to be implement-ed. An optimal and integrated real time control system will also be proposed from this research work. Objectives Methodology To develop an improved model from the first principle of CFD approach in order to simulate polymerization in batch reaction in fluidized bed catalytic reactor for olefin production. Development of an advanced simulation model which will be developed to describe the mecha-nism of olefin coordination polymerization to get a detailed picture of the molecular structure for homopolymer and copolymer made with coordination reaction mechanisms. A comprehensive study will be conducted through CFD approaches with support of available computational re-sources. Non-linear process model based control will be studied for optimal control of fluidized bed catalytic reactor under various conditions. Final validation study will be conduct to suggest the advanced control system. To develop a practical tool to predict polymer production rate and product quality on an industrial scale.To develop an advanced control system for a gas phase olefin reactor using real time advanced control system Outcome Development of advanced model and optimal control system for industries can be used to in-crease the yield of Olefin production in Petrochemical Plants at Kertih, Malaysia which will be a cost effective and practical process tool for real plants. Possible High Impact Journals for Publications 1. Industrial & Engineering Chemistry Research 2. Chemical Engineering Journal 3. Progress in Polymer Science 4. Powder Technology Collaborators 1. Prof. I.M.MUJTABA; School of Engineering, Design & Technology University of Bradford. Bradford BD7 1DP, UK 2. Dr. Nayef Mohamed Ghasem, Department of Chemical and Petrolium Engineering, UAE university, Al Ain, United Arab Emirates. 3. Prof Zheng-Hong Luo; Shanghai Jiao Tong University, Shanghai, China 4. Prof. Dr. Navid Mostoufi; Department of Chemical Engineering University of Tehran, Iran. 99 100 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/26 Title: Nano-mechanical Properties of Advanced Lead Free Solder for Microelectronics Packaging. Principal Investigator: Prof. Dr. A.S.M.A. Haseeb Department: Department of Mechanical Engineering Summary of Research Proposal Recent environmental concerns are forcing semiconductor industry to come up with lead free, green electronic products that can ensure reliability. Apart from the drive to go lead free, semi-conductor industry is also experiencing a trend towards miniaturization. Interconnects with small dimensions have interfacial intermettalic compound (IMC) that constitutes a larger fraction of the solder volume. Therefore IMC properties are becoming ever more important as miniaturization continues. To understand and predict the performance of small solder interconnects, it is highly important to measure and understand the properties of materials at small dimensions (submi-cron/ nanometer). In this project, evaluation of nanomechanical properties of ultra-small inter-connects will be done by nanoindentation technique which can measure mechanical properties of materials with dimensions down to a few tens of nanometers. Objectives Methodology 1. Preparation of solder Sn-base solder will be carried out with and without alloy additions using: 2. To study the properties of different phases in lead free solder. To investigate the effect of alloy additions on the hardness and modulus of interfacial IMC. 3. To examine the influence of processing and treatment conditions on mechanical properties. 4. To study the nanoindentation creep of various phases in lead free solders. 1. conventional metallurgical alloying, 2. nanoparticle addition method, and 3. solid state diffusion of nanolayers. In-depth structural and chemical characterization of the solders will be done by using microscopic, diffraction and spectroscopic techniques. Mechanical properties of the prepared solders will be studied by nanoindentor. Outcome New Knowledge about the nanomechanical properties small solder interconnects. Possible High Impact Journals for Publications 1. Materials Science and Engineering A 2. Intermetallics 3. Journal of Alloys and Compounds 4. Advanced Materials 5. Nano Letters Collaborators: Prof. Samjid Mannan, King’s London College, United Kingdom. High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/27 Title: Bovine Hydroxyapatite Derived Porous Bone Graft for Biomedical Application Principal Investigator: Prof. Dr. Mohd Hamdi Abd Shukor Department: Faculty of Engineering Summary of Research Proposal Demand for development of biomaterial study arises due to improvement of average human lifespan, as well as higher expectation of the quality of life. The success of biomaterial application critically depends on the achievement of a stable attachment to connective tissue. In producing a feasible biomaterial which will survive in the body for a long period of time, the identified material needs to be developed specifically for clinical application. Hydroxyapatite (HA), a calcium phosphate ceramic, is chemically similar to the mineral component of bones and hard tissues in mammals. It is one of few materials that are classed as bioactive, meaning that it will support bone ingrowth and osseointegration when used in orthopaedic, dental and maxillofacial applications. Various techniques have been developed to produce hydroxyapatite such as sol-gel method, hydrothermal method, electrophoretic deposition, continuous precipitation and solid-state reaction. There has been a constant quest to scale up the process to bulk processing, thus many research have tried to obtain HA from abundant natural sources. Objectives Methodology Outcome 1. This project will strengthen the fundamental knowledge required in the field of biomaterial technology, bovine hydroxyapatite and to explore new method to produce porous bone graft. Parallel sub-projects will encompass a wide range of research scope within the research field including laboratory experimental work (Preparation of Bovine hydroxyapatite Fine Powder Via Calcinations Method, Development of Porous bone graft and Development of reinforced Bovine Hydroxyapatite Porous structure) and material characterizations. The major focus of the research is on the fabrication and development of porous bone graft for biomedical applications. No. of Tier 1 Publications Expected : 27 To determine the parameters that influence bovine hydroxyapatite fine powder preparation. 2. To develop and evaluate the performance of porous bone graft suitable for biomedical application. 3. To characterize the physical, chemical and mechanical properties of porous bone graft. (a) List of current publications : 1. Ceramics international (Impact Factor: 1.751, Tier 1) Possible High Impact Journals for Publications 1. Biomaterials (Impact Factor: 6.646, Tier 1) 2. Journal of Materials Chemistry (Impact Factor:4.646, Tier 1) 3. Int. Journal of Engineering Science (Impact Factor: 1.366, Tier 1) 4. Materials Science and Engineering: A (Impact Factor: 1.806, Tier 1) 5. Materials Characterization(Impact Factor: 1.225, Tier 1) Collaborators Professor Ari Ide-Ektessabi, Kyoto University 101 102 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/28 Title: Reconstruction of Artificial Prosthesis Limbs Principal Investigator: Professor Dr. Imtiaz Ahmed Choudhury Department: Engineering Design and Manufacture Summary of Research Proposal Every year millions of people throughout the world become impaired suffering of osteoarthritis, stroke, poliomyelitis and hemiplegia. About one half of stroke survivors live with impairments such as muscle weakness, abnormal muscle tone and sensory impairments of lower limb mus-cles. Clinical lower limb orthotics increase mobility for a wide range of individuals. By using or-thosis about 52 to 85% of hemiplegic patients regain the capacity to walk. In this case, a stance control knee–ankle–foot orthosis (KAFO) may be appropriate. This type of orthosis is composed of several segments which act on both the knee and the ankle joint. Objectives Methodology Outcome 1. We aim to reduce muscle activation without changing the kinematics. Preservation of kinematics served as a starting point in the required characteristics of our project, among which are: device weight, comfort, and simplicity. Comfort, simplicity, and manufacturability are the prime criteria for our design. A simple design with good control system reduces device weight by implementing fewer components and makes the device easier to manufacture. Later on completing the experimental design we will also prepare a CAD design of the prototype before going for final drawing. After completing the design and CAD works we will go for the final prototype making and modeling. Later on we have to collect some data and analyze the results using the knee orthosis in motion analysis lab. The data collection would on: joint and orthosis kinematics anal-ysis, torque and torsion analysis, knee moments with respect to joint angle and stiffness, muscle activation level, adaption rate etc. 1. To improve the quality of life of various impaired patients in Malaysia 2. To develop the local technology (in the field of design and fabrication) of lower limb orthotics 3. Development of local expertise 4. Manufacture such kind of lower limb orthotics locally 2. To design and develop robotic knee and knee ankle foot orthosis suitable for impaired pa-tients assisting mobility of lower extremity. To validate the design by collecting data from real subjects and analyzing for improvement, if necessary, in the design. 3. To develop a better control system of the orthosis 4. To determine the usefulness for specific applications of the ortho Possible High Impact Journals for Publications 1. Archives of Physical Medicine and Rehabilitation 2. Clinical Biomechanics 3. Journals of Biomechanics 4. Journal of Rehabilitation Research and Development 5. Medical Engineering and Physics Collaborators Professor Dr. Mustafizur Rahman, Dept. of Mechanical Engineering, NUS, Singapore. Professor Dr. Peter Lee, Dept. of Mechanical Engineering, University of Melbourne, Victoria Professor Dr. Arthur Mak, Dean of Students Office, The Hong Kong Polytechnic University High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/29 Title: Fabrication and Characterisation of High Efficiency Green Technology devices (Solar cells and Thermoelectric Devices) Principal Investigator: Dr Suhana bt Mohd Said Department: Department of Electrical Engineering, Summary of Research Proposal This project is concerned with the fabrication of high efficiency electronic devices which are considered “green technology”, ie harvest nature’s available resources into electricity. The research strategy involves synthesizing novel organic based electronic materials, and fabricating them into solar cells and thermoelectric devices. The use of inkjet printing to fabricate thermoelectric devices will be a pioneering technique in Malaysia. To complement the experimental work, simulation work on the molecular (Accelrys Materials Studio) and device level (Silvaco, COMSOL, ANSYS) are also tackled. The end point of this research is not only concerned with fundamental, high impact stud-ies on the physics, chemistry and engineering of these green technology devices, but it is hoped that these discoveries will also translate into practical devices for energy harvesting. Objectives Methodology 1. Molecular and device simulation are first carried out to identify optimal device and material pa-rameters for solar cells and thermoelectrics. Synthesis and fabrication of the device is then car-ried out, using inkjet printing and electrospinning. Characterisation of the devices is then carried out to determine its performance. 2. To synthesise materials for high efficiency solar cells and thermoelectric devices using nanotechnology To fabricate high efficiency solar cells and thermoelectric devices using materials synthesized in (1) Outcome 1. Design and synthesis of novel materials for solar cells and thermoelectrics 2. Fabrication of organic solar cells and thermoelectrics using inkjet printing. Possible High Impact Journals for Publications 1. Journal of Nanoparticle Research 2. Nanotechnology 3. Energy 4. Advanced Materials Collaborators Professor Takahito Ono, Tohoku University, Japan. Associate Professor Munehiro Kimura, Nagaoka University of Technology, Japan. 103 104 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/30 Title: A new technique to mitigate CO2, NOx, SO2 emissions simultaneously in a circulating fluidized bed system Principal Investigator: Dr. Brahim Si Ali Department: Chemical Engineering Summary of Research Proposal Oxy-fuel combustion technology consists of combusting the fuel in mixture of oxygen and recycles the flue gas back into the furnace to control the adiabatic flame temperature and enrich CO2 concentration to levels as high as 95% by volume. Co-gasification involves a portion of biomass along with the coal which helps in reduction of NOx and SOx emissions. This unique process will be performed in newly designed dual fluidized bed reactor. The function of this design is to trap the bio-oil from one reactor which will be further purified for further applications and pure & enriched CO2 will be produced from the second reactor for easy sequestration. Objectives Methodology The design of a dual fluidized beds reactor system in which one acts as a gasifier and another as combustor with loop seal. The condensable gases will produce bio-oil for further applications. The basic characteristic properties of the coal/biomass (ultimate and proximate analysis) will be analyzed prior to do initial experiments in thermo-gravimetric analysis (TGA). The most important experiments will be the findings of the optimum O2 proportions in the oxidant gas and the desired CO2 proportions in the product gas. Co-gasification is a heterogeneous reaction hence already developed gas-solid models will be implemented like random pore model, quantize solution model etc. Simplified quasi-global mechanisms and rate expressions need to be developed for the volatiles. The implementation this oxy-fuel technology for high concentration of CO2 in the flue gas in dual fluidized beds reactor. Retrofitting this technology and new reactor system to the existing plants will lower the NOx and SOx emissions up to zero is achieved by mixing biomass with coal in dif-ferent ratios. Outcome We plan to retrofit this new technology to the existing plant. Further understanding of the de-signing and modeling of the dual fluidized bed reactor system for this new technology. Coal, biomass and their different blends for the production of CO2, NOx, and SO2 in the reactor sys-tem will be compared. Possible High Impact Journals for Publications 1. Energy 2. Energy conversion and management 3. Fuel processing technology 4. Fuel 5. Chemosphere Collaborators Prof. Sang Done Kim, .Chemical & biomolecular engineering dept. Korea Advanced Institute of Science and Technlogy, Gusongdong, Yuseong-gu Dr.Muhammad Irfan, University of Alberta Edmonton, AB Canada High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/31 Title: Sustainable Resource Conservation Approach to the End of Life of Electrical & Electronic Equipment in the Context of Energy, Process and Carbon Offsetting: A Study for Malaysian Industry Principal Investigator: Assoc. Prof. Dr. Shamsuddin Ahmed Department: Engineering Design and Manufacture Summary of Research Proposal Sustainable manufacturing and product recycling now has to be hand-in hand. An energy effi-cient durable process with less carbon emission in environment is now just a demand of time in manufacturing and End of life (EOL) product treatment. Recycling may be considered as a source of renewable energy. EOL of products have of multi-degree of complexity WEEE (waste electrical and electronics equipment), and a new approach in the field of reuse, recycling, re-manufacturing is to make for conserving the resources from a sustainable view point in the con-text of Malaysian Electrical and Electronics industry. Objectives Methodology Using European model, system dynamic approach and mathematical programming, this project aims to develop a sustainable resources conservation approach in manufacturing by investigat-ing recycling and remanufacturing potentials for Malaysian EEE industries. The project will develop an integrated resource management framework through the investigation of recycling po-tential of waste electrical and electronics devices. It will characterize recycling, reuse and re-manufacturing of e-waste in the contrast of industrial sustainability via system dynamic and ex-perimental approaches. It will also develop mathematical heuristic and optimization solution algorithm based on cost, productivity and flexibility criteria. There are several steps for implementation. It will employ a two-step methodology framework development to compare system architecture, context, performance, sustainability, performance and regulation with the benchmark and a comprehensive system model development by identifying the relevant factors for the overall system performance. System dynamic programming, mathematical modeling etc. will be done to achieve the objectives. Outcome 1. Systematic collection and recollection of WEEE items. 2. System dynamic modeling for long-term sustainable reuse of WEEE. 3. Mathematical modeling on economic, environmental and technical aspects. Possible High Impact Journals for Publications 1. International Journal of Product Lifecycle Management 2. International Journal of Sustainable Manufacturing (IJSM) 3. International Journal of Integrated Waste Management, Science and Technology 4. An International Journal of Manufacturing, Product and Process Development 5. International Journal of Integrated Waste Management, Science and Technology Collaborators Probable collaborators are: Malaysian Industrial development authority (MIDA). Malaysian Institute of Economic research, and Department of Environment Malaysia. 105 106 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/32 Title: Campus Network Smart Grid System for Energy Security Principal Investigator: Professor Dr Nasrudin Bin Abd Rahim Department: UM Power Energy Dedicated Advanced Centre (UMPEDAC) Summary of Research Proposal To develop a model and prototype a smart grid campus network system and to investigate properties of control algorithms, power system reliability and system protection for grid connect-ed solar PV energy, wind energy simulator that connects to the campus network grid system. The parallel operation of the inverter units in grid-connected and islanded mode of operation will be studied. To provide necessary conditions for the stability and power quality testing, a distribu-tion system and test loads will be designed and developed. Three inverters connected in parallel can provide a realistic testing environment and represent a power park or remotely connected inverters (depending on the line impedance between them). To support the operation of the distributed control method or role of the grid supervisor, the supervisory control unit will be built. High level monitoring, control and system debugging will be enabled by using a high performance computer. Various test loads will be used to obtain the system steady-state and power quality performance. Objectives Methodology Outcome To develop a model and prototype a smart grid campus network system. New harmonic sources such as motor control devices, interconnection of wind and solar power converters in distribution systems will be studied. The system will be modeled in Matlab software to investigate various operation methods of distributed generation system. The simulation result will be realized and it will depend on geographical and electrical distances between various generators. A list of test cases for distributed network will be made and any problems arising from the system will be corrected. New algorithms for control, power system reliability and system protection. To investigate properties of control algorithms, power system reliability and system protection for grid connected solar PV energy, wind energy simulator that connects to the campus network grid system. Possible High Impact Journals for Publications 1. IEEE Transactions on Industrial Electronics 2. RENEWABLE & SUSTAINABLE ENERGY REVIEWS 3. ENERGY 4. APPLIED ENERGY Collaborators University of Wollongong, Australia (Assoc. Professor Kashem Muttaqi) High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/33 Title: Numerical simulations and experimental investigations on the multiaxial fatigue and cyclic plastic response of the newly developed aluminum alloy and FGM for aerospace structures Principal Investigator: Judha Purbolaksono Department: Department of Engineering Design and Manufacture Summary of Research Proposal Fatigue failure can be visualized as the stress intensities and redistribution of the loading at the material due to notches, surface roughness or any material deficiencies. The cyclic plastic deformation and crack initiation are later occurred. But there is insufficient work on the effects of cyclic plasticity for fatigue life prediction of materials, especially on the aerospace materials under proportional and non-proportional loadings. The range of ability of the cyclic plasticity models including multi-surface and non-linear kinematic hardening models is studied in detail. Objectives Methodology Outcome Determine properties and coefficients of the materials through uniaxial and multiaxial fatigue tests. Evaluate the materials fatigue life considering interaction of plasticity and fatigue models. Investigate the effects of proportional and non-proportional loadings on the cyclic plastic response of the materials. Predict the expected fatigue life of the materials in the typical aerostructures. Perform uniaxial and multiaxial fatigue tests on the materials. Conduct simulations of fatigue crack growth of the standard specimen models using the newly generated coefficients and properties (by using a Boundary Element software package). Establish the computer model to evaluate the materials fatigue life by considering interaction of plasticity and fatigue models. Determine axial and torsional cyclic plastic responses of materials under various loading conditions using a software package of finite element. Important findings from this research are plasticity models for the evaluation and analysis of the cyclic plastic response and multiaxial fatigue life in the proportional and non-proportional loadings with different strain paths by packages of FEM for aerospace materials. Furthermore, it will enhance the fatigue life predictions. Thus the reliability of machines and aerospace structures under cyclic loadings will be increased. Possible High Impact Journals for Publications International Journal Of Fatigue; International Journal Of Plasticity; Engineering Analysis With Boundary Elements; Materials And Design; Engineering Structures Collaborators Prof. M.H. Aliabadi, Chair in Aerostructures, Department of Aeronautics, Imperial College, UK. 107 108 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/34 Title: Coastal protection using Eco-Engineering technologies Principal Investigator: Prof. Ir. Dr. Roslan Bin Hashim Department: Civil Engineering – Faculty of Engineering Summary of Research Proposal Sea level rise, increased global temperature and concentration of atmospheric CO2, threaten the landward of the coasts through phenomena such as sediment erosion, excessive inundation stress and increased water salinity. Mangrove forests are indigenous inhabitants of coastal re-gions in tropical and sub-tropical countries. They provide services for shore ecology and human through protection and raw material. FAO estimated that the total area of mangroves at 16.1 million hectares on 1990 decreased drastically to 15.4 million hectares on 2010. This triggers an alarm for all 124 countries in the world which stated the existence of Mangroves in their territory regardless of the volume. On the other hand, wave energy and sediment loss can deteriorate the man-made infrastructures on-land ward and sea-ward of the coasts. The implementation of eco-friendly concepts in coastal protection techniques to minimize envi-ronmental anthropogenic effects is still an open question. Eco-engineering technologies reconcile man-made structures and ecological features to solve the complicated brutal forces of nature. Objectives Methodology Outcome Minimization of coastal erosion and rehabilitation of mangrove forests, are the focal points of this study. On the narrower scale, it is intended to plan to design, construct and monitor the effect of various costal protection structures such as revetment and detached-breakwater system on improvement of geotechnical characteristics in land-ward of coasts. Existing armoring units called, “L-Blocks” (Roslan Hashim et all [2010]) will be modified in terms of structure and mate-rial based on the nature of usage. Sustainable Polymeric Geosynthetic (SPG) will be used as an innovative construction material to increase structural stability, lessen wave-induced deformation and amplify effective stress. Simultaneously, the artificial mangrove replantation will be carried out on provided shelter area. Bathymetric data will be collected throughout the study to assess the effectiveness of the project. It is aimed to hire an interdisciplinary approach in this study. Agriculture sciences, geotechnical studies, knowledge of coastal hydraulics, structural analysis, innovative construction methods, mathematical and statistical analysis will be all involved in this research. The kinematic wave data, wind forecast and tidal elevation table will be collected from Malaysian Meteorology De-partment. Geotechnical tests including Mc.Probe, Triaxial test, VCT, Altenburg Consistency lim-its and volumetric physical, will be carried out. Numerical modeling using FEM and FDM will be carried out by software such as Plaxis, Abaqus and Mike 21 based on the type of structure. Full-scale bathymetric plans will be prepared using delicate land-surveying measures. Statistical analysis for derivation of standard table of design for modified L-Blocks will be carried out based on parametric and full-scale studies. Other tests for construction materials will be done according to ASTM standards. Also various mangrove replanting techniques using different pattern and type of distribution is aimed to be performed to rehabilitate the lost mangrove forests. 1. To assess the effectiveness of ecological methods in coastal protection methods. 2. Rehabilitation of deteriorated mangrove forests in endangered areas of Peninsular Ma-laysia. 3. Modification of existing armoring units called , “L-blocks” 4. To enhance near-shore and on-shore geotechnical characteristics. 5. To construct detached breakwater system and revetment unit for dampening of storm surges and wave energy. High Impact Research Annual Report 2012 Possible High Impact Journals for Publications Construction and Building Materials ( IF : 1.834); Ecological Engineering ( IF : 3.415) ; Journal of Experimental Marine Biology and Ecology( IF : 1.875) ; Estuaries and Coasts ( IF : 2.109); Coastal Engineering ( IF : 1.757); Climatic Change ( IF : 3.385); Estuarine, Coastal and Shelf Science ( IF : 2.247). Collaborators Dr. Roger A. Falconer, Professor, Cardiff University, United Kingdom Dr. Samsudin Taib, Associate Professor, University of Malaya, Malaysia Dr. Zubaidah Ismail, Associate Professor, University of Malaya, Malaysia Dr. Shatirah Akib, Senior Lecturer, University of Malaya, Malaysia Ahmad Mustafa Hashim ( M.Sc), Associate Professor, University Technology Petronas, Malaysia Project No: UM.C/625/1/HIR/MOHE/ENG/35 Title: An Integrated Production Planning and Decision Analysis System for SMEs Principal Investigator: Assoc. Prof. Dr. Siti Zawiah Md. Dawal Department: Centre for Product Design & Manufacture (CPDM) Department of Engineering Design & Manufacture, Faculty of Engineering Summary of Research Proposal According to SMIDEC report, there are 552,804 SMEs establishment in Malaysia (Dato Hafsah Hashm, Cer-SMIDEC, 2009). More than 90% of the SMEs are in manufacturing (Teh Kee Shin, President SME Association of south Johor, 2009). To maintain competitiveness, future manu-facturing companies including SME’s need to be flexible and adaptive in their operating struc-tures. In this trend, a new solution tool dedicated to help SMEs’ decision making in facilities and production planning that accommodates turbulence demand, sustainable manufacturing as well as operator safety and well-being is proposed. Objectives Methodology Outcome The main objective of this research is to identify and develop the system based on the relevant factors to optimize SMI’s production system on turbulence demand, sustainable manufacturing as well as operator safety and well-being. The research methodology is conducted using the following phases. In the first phase a survey will be conducted to design engineers in industrial companies in order to get their views on re-search implementation and application from the industry perspective. In the second phases of this research a developing a conceptual framework and model in Eco Process Planning for Sustainable Manufacturing will be developed. New knowledge of humanmachine interaction model for SME’s production in Malaysia. Developing a methodology on digital factory-based integrated design approach for flexible manufacturing system and developing a methodology on multi-level optimization model for generalized production system layout and scheduling planning 109 110 High Impact Research Annual Report 2012 Possible High Impact Journals for Publications Applied Soft Computing, Computers & Industrial Engineering, Computers & Operations Re-search, Robotics and Computer-Integrated Manufacturing Collaborators Professor Dr. Keith Case, Loughborough University, United Kingdom. Professor Dr. Stephen Evans, University of Cambridge, United Kingdom. Professor Dr. Masaru Nakano, Keio University, Japan. Professor Dr. Hideki Aoyama, Keio University, Japan. Professor Dr. Zahari Taha, University Malaysia Pahang (UMP) Project No: UM.C/625/2/HIR/MOHE/ENG/36 Title: Strengthening structural elements for load and fatigue using advanced techniques. Principal Investigator: Prof. Ir. Dr. Mohd Zamin Jumaat Department: Civil Engineering Summary of Research Proposal Modern highway bridges are in serious need of rehabilitation as a result of deteriorated structural components. Therefore, there is an urgent requirement for development of inexpensive and unobtrusive rehabilitation technique such as adhesive bonding or bolting steel or fiber reinforce plastic(FRP) plates for reinforced concrete structure (Deric J. 2001). Various loads such as stat-ic and fatigue loads can cause large cracks and deflections which will reduce the durability of structures. Many bridge structures in Malaysia which are subjected to repeated loads are now carrying more loads than before and in need of strengthening. Extensions of service life of these engineering structures not only save the economic cost but also ensure sustainable development through reduction in energy required to produce new materials for replaced structures as well as minimization of disposal of old structures. Objectives Methodology In specific terms, the study focuses on studying the overall behavior of plate bonded strength-ened structural elements. From this research effective method for strengthening of structural elements using plate bonding method for loads and fatigue will be developed. At the end fatigue reliability analysis of the strengthened structural components will be carried out. From the literature review, effective materials and methods of strengthening structural elements under loads and fatigues will be selected. The mechanisms of premature debonding failures will be identified. Based on the mechanisms of premature failures, design methods of anchors will be proposed. Methods of strengthening using CFRP laminate to eliminate IC debonding will also be proposed. Finally, the technique to conduct the experimental works on specimens under loads and fatigue will be identified. The optimal dimensions of strengthening plates based on design method will be obtained. Experimental works will be carried out on un-strengthened and strengthened structural elements under loads and fatigue. All structural elements will be modeled using FEM package software to compare the results with experimental findings. High Impact Research Annual Report 2012 Outcome Proposing effective methods for preventing premature failures of strengthened structural elements. Recommendations for effective method of strengthening structural elements using plate bonding method for loads and fatigue. Development of FEM for predicting the behaviour of strengthened structural elements under various load and fatigue. Possible High Impact Journals for Publications 1. Engineering Structures 2. Construction and Building Materials 3. Computers & Structures 4. Composite Structure 5. Journal of Civil Engineering and Management 6. Automation and Construction Collaborators Prof. Dr. Deric John Oehlers (Deng., PhD., MSc, BSc. MIEAust) Professor of Structural Engineering School of Civil, Environmental and Mining Engineering The University of Adelaide, Australia Project No.: UM.C/625/1/HIR/MOHE/ENG/37 Title: Modification Of Fenton Oxidation Pro-cess For Treatment Of Recalcitrant Wastewaters Principal Investigator: Professor Ir. Dr. Abdul Aziz bin Abdul Raman Department: Department of Chemical Engineering Faculty of Engineering University of Malaya Summary of Research Proposal Pollution caused by wastewater containing recalcitrant contaminants can cause severe envi-ronmental and health problems. Recalcitrant wastewaters typically contain components like phenol, carboxylic compound and others, which can be found in variety of wastewaters. Such wastewaters include resin-producing factory discharges, textile wastewaters, petroleum refinery wastewaters, metal working fluids and pharmaceutical effluents. Advanced oxidation processes (AOPs) have been effective in treating recalcitrant and non-biodegradable wastewater. One category of AOP is the Fenton Oxidation. Various Fenton and improved-Fenton treatment pro-cesses for recalcitrant wastewaters will be developed in this work. This is a fundamental and application research where focusing on areas which can contribute to wider application for eco-nomically treating recalcitrant wastewater. Objectives Methodology This research seeks to develop enhancements on the treatment capability of conventional Fen-ton Oxidation process and to develop a treatment system for selected wastewaters at laboratory and pilot scale. The performance of Fenton oxidation treatment will be established using conventional Fenton reagent for single recalcitrant aromatic components. Development of enhancers will include alternative oxidants, novel catalysts, catalyst improvements and irradiation assistance. Kinetic, performance and comparative studies will be conducted to model and optimise the process. Models will be used to conduct scale up studies and pilot scale reactors will be designed to carry out on-site testing. Integrated technologies like advanced membrane separation will also be explored as a pre- or posttreatment step for AOP treatment system. Outcome 1. New catalysts and enhanced catalyst. 2. Pilot scale mobile treatment unit. 111 112 High Impact Research Annual Report 2012 Possible High Impact Journals for Publications 1. Journal of Membrane Science 2. Chemical Engineering Journal 3. Chemical Engineering Research and Design 4. Chemical Engineering Science 5. Chemical Engineering Data Collaborators Professor Dr. Wan Mohd. Ashri Wan Daud (Co-PI), Department of Chemical Engineer-ing, Faculty of Engineering, University of Malaya. Professor Dr. Nik Meriam Nik Sulaiman, Department of Chemical Engineering, Faculty of Engineering, University of Malaya. Professor Dr. F. Handan Tezel, Department of Chemical and Biological Engineering, Faculty of Engineering, University of Ottawa, Canada. Project No.: UM.C/625/1/HIR/MOHE/ENG/38 Title: Custom Based Development Of Bio And Chemical Reactors Using Advanced Fluid Dynamic Studies Principal Investigator: Professor Ir. Dr. Abdul Aziz bin Abdul Raman Department: Department of Chemical Engineering Faculty of Engineering University of Malaya Summary of Research Proposal Stirred vessels can be found in almost all chemical manufacturing premises and may outnumber other unit operations by far. Stirred vessels can be used for various applications through combi-nation of mass, heat and momentum transfer operations. The application can range from a sim-ple operation to maintain uniformity of temperature or concentration or even to create high mass transfer environments. This warrants a relook into the development of systems with innovative designs, non-conventional vessels or agitation configurations to adapt to specific applications. A complete mixing technology testing facility will allow for a detailed finding on hydrodynamics and mixing phenomena to be obtained. Furthermore, in Malaysia there are more than 100,000 man-ufacturing industries that use stirred vessels for various applications. Objectives Methodology This research aspires to study wide range of chemical and biological reactor operation in the laboratory by employing simulated and actual conditions using state of the art facilities. Through this study, significant information in the form of mathematical models can be developed and tested for various industries for achieving higher efficiency through advanced imaging, visualisa-tion and simulation techniques. A complete facility will be set up to conduct mixing performance studies system for various configuration of stirred vessel, types of impellers for combinations of phases available in the industry. This facility will be able to perform in depth mass transfer, heat transfer and hydrodynamic studies for Newtonian, nonNewtonian and even high concentration medium to replicate various critical application of mixing systems. Several systems will be identified to conduct scale- up and scale-down work in order to generate reliable procedures to generate mixing performance data for industrial scale stirred vessels for selected bioreactor and chemical reactor application. High Impact Research Annual Report 2012 Outcome 1. A complete stirred vessel test-centre for the country or even at regional level. (Currently, no such centre exists in the region.) Possible High Impact Journals for Publications 1. Renewable and Sustainable Energy Reviews 2. Reviews In Chemical Engineering 2. Novel impellers design. 3. 3. New techniques for power and mass transfer measurement. Chemical Engineering Journal 4. Computers & Chemical Engineering 5. Chemical Engineering Science Collaborators Professor Dr. Shaliza Ibrahim (Co-PI), Department of Civil Engineering, Faculty of Engineering, University of Malaya. Dr Rajarathinam Parthasarathy, Civil, Environmental & Chemical Engineering Depart-ment, Royal Melbourne Institute of Technology, Melbourne, Australia. Project No: UM.C/625/1/HIR/MOHE/ENG/39 Title: Powering Up Paralyzed Muscles Using Functional Electrical Stimulation (FES): An Advance in Rehabilitation Engineering Principal Investigator: Dr. Ahmad Khairi Abdul Wahab Co-PI: Dr. Nur Azah Hamzaid, Dr. Nazirah Hasnan (Faculty of Medicine) Department: Biomedical Engineering Summary of Research Proposal Functional Electrical Stimulation (FES) is a method that uses electrical pulse to generate muscle contraction; its application can be roughly divided into two categories: upper limb and lower limb. To restore the walking motor function of the lower limb via FES is a hard job; however FES cycling movement is relatively an easy task and can provide the foundation for FES walking. Accordingly it can exercise the muscles, increase range of joint motion and improve cardiopul-monary fitness. As a result of fast growing technology and achievements in integrated electron-ics, there is significant increase in the speed and complexity of modern microcontrollers. Using new microcontrollers with integrated memory modules and peripherals, it is possible to design single-chip controlled stimulators. The integrated microcontroller modules can replace special-ized hardware circuits that were typically applied in earlier designs. This research will also involve the modeling of muscle-electrical responses, FES stimulator and system development, mechanical and software development, patient rehabilitation and intervention studies. While several research and clinical trials have been conducted to establish several factors contributing towards effective FES evoked cycling activity, such as the most suitable electrical current parameters, the optimal frequency, duration and intensity of training, as well as integrated technol-ogy to effectively deliver the current to the targeted paralyzed muscles, muscle fatigue is still the established barrier to effective training. To date, there has yet to be established the most effec-tive ‘mode’ of cycling and the best possible use of surface or implanted sensory system to deliv-er feedback to the FES system for optimum stimulation parameters. Therefore, the prime expected novelty of this project is the development of a new direct sensory system to identify evoked muscle performance to optimally deliver current to the muscles. This sensor will contribute to the lack of established muscle feedback during FES evoked exercise, to eliminate or reduce fast muscle fatigue effect, which is a primary cause of inefficient FES ex-ercise activity. 113 114 High Impact Research Annual Report 2012 Objectives This project will focus on the following; 1. To development of electronic circuit for six-channel functional electrical stimulation. 2. To develop the portable multi-channel system of functional electrical stimulation (FES). 3. To develop the programmed multi-channel cycling and exercise system. 4. To develop a new sensory system to monitor muscle performance and fatigue for opti-mized activity. Methodology At the early stage, FES components review and development are carried out and followed by pulse tests on biological muscles, component integration and optimization. The development of communication modes with other integrated exercise devices will be formulated. Clinical trial runs and patient evaluation session will be used. Further tests such as stimulation on muscle strength, efficiency, endurance and others will also be implemented to test for reliability, effec-tiveness and efficiency of the developed devices. Clinical studies are also being conducted to investigate the effects of FES compared to conventional intervention for the target population. Finally, at the identified milestones of the project, publications are targeted at the high ranked journals. Outcome New sensory and monitoring system to identify evoked muscle performance to optimally deliver current to the muscles will be developed. This sensor will contribute to the lack of established muscle feedback during FES evoked exercise, to eliminate or reduce fast muscle fatigue effect, which is a primary cause of inefficient FES exercise activity. New method to deliver rehabilitation exercise, evaluation and training system in practicing new rehabilitation techniques to help the disabled to exercise their paralyzed muscle and provide possibilities in having to do activities such as normal persons do. Possible High Impact Journals for Publications 1. Journal of Biomechanics 2. Clinical Biomechanics 3. IEEE Journal of Rehabilitation Engineering & Development 4. Biomedical Microdevices 5. IEEE Signal Processing Magazine 6. Clinical Studies 7. Advances in Applied Mechanics Collaborators Prof. Dr. Glen M. Davis, Professor of Clinical Exercise Sciences Convenor, Exercise Health and Performance Research Group and Director, Clinical Exercise and Rehabilita-tion Unit, Faculty of Health Science, The University of Sydney Dr. Anwar Suhaimi, Prof. Madya Dr. Lydia Abdul Latif, Dr. Aishah Ahmad Fauzi, De-partment of Rehabilitation Medicine, Faculty of Medicine, University of Malaya. Project No: UM.C/625/1/HIR/MOHE/ENG/40 Title: Nano-fluids in enhancing the performances of heat exchangers Principal Investigator: Professor Dr. Saidur Rahman Department: Mechanical Engineering Summary of Research Proposal The nanofluid has superior heat transfer capabilities due higher thermal conductivity compared to conventional fluids. In this work, Nanofluids will be prepared and characterized using suitable methods and techniques. Fundamental properties of nanofluids will be investigated along with heat transfer performance in heat exchangers. A system will be developed for the thermal performance investigation of heat exchangers (i.e. boiler, solar collector, and electronics). Energy savings and emission reductions are also expected with the application of nanofluids in heat exchangers. Mathematical formulations/co-relation will be developed to estimate energy savings and emission reduction associated with heat transfer enhancement. High Impact Research Annual Report 2012 Objectives Methodology Outcome 1. To prepare and characterize nanofluids 2. To investigate the thermal and rheological characteristics of nanofluids Energy efficient heat exchangers and publication in top quality journal 3. To investigate the thermal performances/heat transfer in heat exchanging devices such, boiler, cooling of electronics, improving solar collector efficiency and etc Nanofluids will be prepared by using two step method. Nanofluids will be characterized by using sediment capture method, TEM, FESEM, Zeta potential, UV visible spectro photometer, etc. The transient hot wire method will be used to measure the thermal conductivity of nanofluids. Rotating viscometer will be used to measure the viscosity of. A density meter will be used to measure the density of nano-fluids. A differential Scanning calorimeter (DSC) will be used for measuring specific heat of nano-suspension. The experimental setup will be developed to measure the heat transfer, pressure drop, energy and exergy analysis of heat exchangers, solar collector and electronic cooling. 4. To estimate energy/ fuel savings along with greenhouse gas reduction Possible High Impact Journals for Publications 1. International Journal of Heat and Mass Transfer 2. International Communication in Heat and Mass Transfer Collaborators Ryerson University, Canada (Prof. Dr. Ziad Saghir) Bangladesh University of Engineering and Technology (Prof. Dr. Md. Mustafizur Rah-man) Razi University, Iran (Assoc. Prof. Dr. Tooraj Yousefi) Project No: UM.C/625/1/HIR/MOHE/ENG/41 Title: Exoskeleton Robotics Device For Limb Impairment Support Principal Investigator: Dr. Norhafizan Ahmad Department: Centre of Product Design & Manufacture (CPDM), Department Engineering Design & Manufacturing Summary of Research Proposal The design of this exoskeleton robotics device is primary use in rehabilitation of the function of the human body, with segments and joints corresponding to those of the person it is externally coupled with. This device has variety of other application areas including rescue, military and recreational activities. Although the supplementary technologies such as measurement and control have advanced vastly in recent times, there are still many challenges related to the exoskel-eton and robotic assistive device development for the progress in their improved and widespread usage. Recent advances have also look into the application of exoskeleton robot in industry namely the in tasks involving hazardous or heavy load. Objectives 1. To benchmark existing market and technology as well as the needs of local demands of exoskeleton robots for various individuals and conditions. 2. To provide optimal database models of human physiological and biomechanical factors for developing control strategy and algorithm for the functions of exoskeleton robot. 3. To measure the performance of exoskeleton robot for increasing system efficiency. 4. To develop a novel structure, mechanism and system approach for the functions of exoskel-eton robot. 115 116 High Impact Research Annual Report 2012 Methodology Outcomes The research is conducted using three stages of development. First stage is to conduct benchmarking studies on the current technology in the market as well as to determine the market growth and demand of the exoskeleton robots for limb impairment support. In this stage the study is investigated the human physiology capability and the biomechanical aspects for the human movement as for the database to develop the control strategy of the device. For the second stage, the control strategy and algorithm for the complete structure of the exoskeleton robots is developed based on existing requirement from the first stage. The construction of the control algorithm is used to determine the optimal mechanism movement for more realistic and smooth device. The final stage is to fabricate the structure and mechanism for the exoskeleton robots of the limb impairment support. This design stage includes sensing system to detect the workload of the handling, repeatability test for reliability of the system devices, safety and ergo-nomics factor for the design. The purpose model is then tested to the specific user in order to improve the design from any problem exist. 1. 2. 3. 4. Locally made assistive exoskeleton robot device and components which comply with Malay-sian standards and safety. Feasibility of a novel mechanical design configurations,new control algorithm planning and adaptibility of the system interface between specific local users and the exoskeleton robot. Build an engineering database of Malaysian biomechanical and human physilogical resources that can be accessible to users of different levels and conditions. Promote links with local hospitals and research institutions for specific exoskeleton robot of interest. Possible High Impact Journals for Publications 1. Robotic and ComputerIntegrated Manufacturing (ISSN: 0736-5845) 2. European Journal of Operation Research (ISSN: 0377-2217) 3. International Journal of Machine Tools & Manufacture (ISSN: 0890-6955) 4. Journal of Materials Processing Technology (ISSN: 0924-0136) 5. Composites Part A – Applied Science and Manufacturing (ISSN: 1359-835X) Collaborators Prof. Dr. Zahari Taha, University Malaysia Pahang (University Malaysia Pahang, Malaysia) Assoc. Prof. Dr. Tan Maw Pin, University of Malaya Medical Centre Prof. Daisuke Kurabayashi, Tokyo Institute of Technology, Japan Assoc. Prof. Naomichi Ogihara, Department of Mechanical Engineering, Keio University, Japan Dr. Herianto, Gadjah Mada University, Indonesia Project No: UM.C/625/1/HIR/MOHE/ENG/42 Title: Design of Image Quality Metric and Pattern Features for Multimedia Applications and Video based Analysis Principal Investigator: P. Raveendran Department: Electrical Engineering Summary of Research Proposal Images are ubiquitous in modern communication, allowing us to transfer information in many different forms (animated and static) and of different content (humans, animals, places, objects) in different genres and communication venues. To increase efficiency, a number of processes compression, transmission, enhancement and etc are used to transform images for easier transmission; however these cause distortions to occur. As human beings are the end users of the images and their evaluation on the acceptability of the reproduction for their needs is still the critical criterion, human subjective assessment of image quality is still regarded the touchstone or benchmark of quality. Subjective assessment suffers from a number of limitations that renders it less than perfect The current research priority, therefore, has been with finding objective image quality metric using orthogonal moments that most closely approximates this subjective evaluation. High Impact Research Annual Report 2012 Objectives Methodology Outcome The objective evaluation involves designing a mathematically defined metric that is low in com-putational complexity, independent of viewing conditions and human observers. The designed objective metric will utilize orthogonal moments for Full Reference and No reference images. The process begins with the review of previous and latest publications related to the study. In the first phase of the research methodology, literature reviews will be conducted to identify the existing algorithms, their bottlenecks and limitations. Formulation of new algorithms that addresses some of these limitations. The mathematical formulation of digital filters to generate both orthogonal polynomials and moments will be studied and implemented. The results obtained will be compared with the state-of-art methods. Design of new image quality metric based on orthogonal moments, and design of digital filters for generating orthogonal polynomials and novel Image processing solutions for applications Possible High Impact Journals for Publications 1. IEEE Trans. Image Processing 2. Pattern Recognition 3. IEEE Trans. on Circuits and Systems Project No: UM.C/625/1/HIR/MOHE/ENG/43 Title: Hybrid Solar Electrochemical and Bioelectrochemical Water Treatment Process Using Activated Carbon Principal Investigator: Professor Mohamed Kheireddine Aroua Faculty: Department of Chemical Engineering Summary of Research Proposal Removing organic and inorganic pollutants from the water source is a necessity in order to pro-tect the environment and human beings. Our recent work at the Department of Chemical Engineering showed the potential of palm shell based activated carbon as electrode material for the electroreduction of heavy metals, electrooxidation, as well as the bilelectrochemical remediation of nitrates. The main disadvantage of the electrochemical based processes is the cost of electricity. In this project we are proposing to develop a hybrid electochemical/bioelectrochemical-solar system for mineral as well as organic pollutant removal from wastewaters. A five year project is planned which will cover laboratory sacle as well as pilot scale studies. Objectives Methodology The objectives of this research are to develop a laboratory scale electrochemical and bioelectrochemical processes using solar energy as source of electricity to remove selected pollutants from wastewater and to sclae up the process. Phase 1 of the project consists of laboratory scale experiments. For this purpose, laboratory scale upflow electrochemical and bioelectrochemical reactors will be constructed based on our previously designed reactors. The reactors will be designed in such a way that they can be operated batchwise as well as continuously. The electrode material will consist of commercially available palm shell activated carbon.A commercially available photovoltaic system will be purchased and combined with the reactors. The data generated during phase 1 of this project will be used to scaleup the process. A pilot scale treatment system will be designed and constructed. The system performance will be evaluated using simulated wasterwater as well as real wasterwater samples. 117 118 High Impact Research Annual Report 2012 Outcome 1. 2. Waste to Wealth concept: use of Palm Shell solid waste as a source of Electrode Material. Added value to Palm Shell based activated carbon Possible High Impact Journals for Publications Bioresource Technology, Water Research, Electrochimica Acta, Journal of Hazardous Materials Pilot plant to determine commercial potential of the hybrid process Collaborators Professor Geoff Howard Kelsall, Imperial College London, UK Dr. Umi Fazara Md. Ali (PhD Imperial College London), Universiti Malaysia Perlis, Malaysia Project No: UM.C/625/1/HIR/MOHE/ENG/44 Title: Regenerative Biomechanics of Human Body Principal Investigator: Prof Ir.Dr.Wan Abu Bakar Wan Abas Department: Biomedical Engineering, Faculty of Engineering Summary of Research Proposal The rapid movement in the field of regenerative biomechanics is the most promising technology for side-stepping in one method both the complex issues of stem-cell ethics and the expensive life-limiting consequences of the metallic prosthesis. It is in understanding the complex biomechanical environments which exist within the human body, by providing supportive structures and frameworks, and through precisely controlling their biomechanical interaction that the pa-tient’s own cells can be used to produce long-lasting, bio-compatible and ethically agreeable repairs. The research therefore includes three major foci: Clinical biomechanics, in particular the relation between forces at the macroscopic level and those produced at the microscopic or cellular level; Cellular response to changes in this biomechanical environment, particularly in terms of ways in which tissue repair, remodeling, production and viability may be produced or increased, via the development and/or fabrication techniques to analyze the said cellular responses; and, investi-gation of other related cellular interactions as low-power electrical field gradient, growth factors, nutrient control or pharmaceutical agents both to improve regenerative biomechanics and to enhance clinical rehabilitation strategies. This focus may lead to the development of individual-ized cell characterization techniques and/or applications. Objectives 1. 2. 3. To characterise the response of individual cells to various extracellular forces, both transient and long term, in real-time using markerless, low-power electrical gradient techniques To characterise the response of tissue to varied expressions of biomechanical loading both in sustained and short term modes To develop techniques, technologies and protocols to permit the efficient and economically effective Methodology extension of regenerative biomechanics toward the clinical sphere 4. To gain new and specialist knowledge of the relationship between gross biomechanics and local tissue regenerative processes The research program will comprise a multi-disciplinary approach comprising major and cutting edge methods from various sectors. These will include: • Real time PCR measurement of tissue and cell genetic expression • Live cell isolation and culture technologies for the evaluation and in vitro testing of processes and the interaction between regenerative physiology and biomechanics High Impact Research Annual Report 2012 • The use of specialised cell lines or non-specialised cell types • The production of theoretical models hypotheses, their evaluation through in vitro and in vivo studies, and iterative improvement of such theories • • • Confocal microscopy and live cell imaging to understand detailed cellular interactions which connect gross biomechanical inputs to tissue and cell level changes in regeneration Real-time, markerless in vitro measurement of cell electrophysiological phenotype using inhouse AC electrokinetics techniques Segregation and sorting of stem cells using AC electrokinetics-based microfluidics Outcome Collaborators Specialist knowledge and a leading group specialised in regenerative biomechanics will permit a much broader application of this field, directly impacting upon clinical applications, pharmeceutical tie-ins and potential benefits for quality of life in general and particularly with reference to recovery from arthritis, osteo porosis, spinal injury and other forms of musculoskeletal adverse pathology. Professor Dan Bader, University of Southampton, UK Dr Tina Chowdhury, Queen Mary, University of London, UK Prof Walter Herzog, University of Calgary, Canada Professor Toshiro Ohashi, Hokkaido University, Japan Possible High Impact Journals for Publications 1. Journal of Biomechanic 2. Biomaterials 3. Journal of Orthopaedic Research 4. Lab on a Chip’ 5. Electrophoresis Project No: UM.C/625/1/HIR/MOHE/ENG/45 Title: Corrosion and fouling mitigation for food industries via modification of heat exchanger Principal Investigator: Dr. Kazi Md. Salim Newaz Department: Mechanical Engineering, Faculty of Engineering. Summary of Research Proposal Intensive studies have been done on the corrosion behavior of cooper in acidic solution, neutral sodium chloride and alkaline solution. No much work have reported on calcium sulphate and carbonate corrosion or fouling and corrosion on copper and other heat exchanger materials in shear fields. In this project, effect of surface energy on deposit formation on heat exchangers used in cooling system and milk pasteurization will be investigated experientially at different operating parameters on SS and other coated surfaces (PTFE, AMC148, TM117P, CNT etc) along with modeling works. Objectives Methodology Outcome To generate data of corrosion effect on copper, brass, SS, nickel, coated surfaces etc. tubes of heat exchangers. Fouling tolerance of the heat exchanger tube of different materials will be studied. Modeling of corrosion and fouling on heat exchanger tubes will be performed. Corrosion and fouling phenomena will be studied experimentally in the controlled environment. Different types of solution at a wide range of concentration along with different test specimens will be used in corrosion study. On the other hand, different types of coated heat exchanger materials at a wide range of temperature and flow rate will be used in fouling experiments. Corrosion data in mineral salts enriched cooling water will be generated. Fouling data of protein and mineral salts on heat exchanger surfaces in food and chemical industries will be acquired. Fouling resistant surface coating will be selected and model of fouling and corrosion will be de-veloped. 119 120 High Impact Research Annual Report 2012 Possible High Impact Journals for Publications 1. International Heat and Mass Transfer, 2. Journal of Thermal Engineering, 3. International Journal of Thermal Science, 4. Chemical Engineering Journal, 5. Applied Thermal Engineering Collaborators Professor Geoffrey G. Duffy, The University of Auckland, Private Bag 92019, Auckland, New Zealand, Phone: 649-3737599 ext.87805, Email: gg.duffy@ auckland.ac.nz. Professor Xiao Dong Chen, Associate Dean International (Engineering), Department of Chemi-cal Engineering, Monash University, Victoria 3800, Australia, Phone: +61-3-9905-9344, Email: dong.chen@eng.monash.edu.au. Project No: UM.C/625/1/HIR/MOHE/ENG/46 Title: Reconfiguration of conduit geometry for heat transfer augmentation of heat exchangers Principal Investigator: Ahmad Badarudin Mohamad Badry Department: Mechanical Engineering, Faculty of Engineering Summary of Research Proposal The separation flow generated by sudden expansion or contraction in passage over steps in many different flow geometries such as heat exchangers for augmentation of heat transfer. The investigation of the effect of different geometries are yet to be done to find a conclusive result, thus in the present research, data generation will be conducted along with modelling of flow separation and reattachment, heat transfer enhancement etc. Objectives Outcome Collaborators Generate data and modeling of augmentation of heat transfer and friction loss due to flow sepa-ration in different conduit geometries. Heat transfer and friction loss characteristic data will be generated. Develop correlation between augmentation of heat transfer and friction loss with conduit configuration and optimize the con-duit dimensions. Develop model for heat transfer and friction loss in customized configured con-duits. Professor Geoffrey G. Duffy, The University of Auckland, Private Bag 92019, Auckland, New Zealand, Phone: 649-3737599 ext.87805, Email: gg.duffy@ auckland.ac.nz. Methodology The apparatus will be designed and constructed to have an axisymmetrical and anaxisymmetric separated and reattached flow in an annular passage. The passage precedes the upstream with a variable test section. The apparatus can provide different fluid velocity (variable Reynolds number) and heat flux at the test section. Possible High Impact Journals for Publications International Heat and Mass Transfer, Journal of Thermal Engineering, International Journal of Thermal Science, Chemical Engineering Journal, Applied Thermal Engineering Professor Xiao Dong Chen, Associate Dean International (Engineering), Department of Chemi-cal Engineering, Monash University, Victoria 3800, Australia, Phone: +61-3-9905-9344, Email: dong.chen@eng.monash.edu.au. High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/47 Title: Sustainable Ocean Energy and Waterway Developments in the Straits of Malacca. Principal Investigator: Associate Prof. Dr. Lam Wei Haur (CEng MIEI). Department: Department of Civil Engineering. Summary of Research Proposal Marine Renewable Energy (MRE) is a new type of renewables compared to the biomass, biogas, solar power and mini hydro in Malaysia. The enactments of Sustainable Energy Development Authority Act 2011 and Renewable Energy Act 2011 provide Feed-in-Tariff (FiT) to encourage the development of renewable energies. Malaysia is a maritime country with high coast/area ratio with potential to harness marine renewable energy. Marine renewable energy includes tidal barrage, marine current energy, wave energy, Ocean Thermal Energy Conversion (OTEC) and salinity gradient power. Marine renewable energy has not been included in the FiT due to the limited knowledge on this marine resource. This project investigates the marine renewable energy associated with the waterway protection in the Straits of Malacca. Objectives Outcome Collaborators Marine renewable energy and the seabed damage due to ship’s propeller wash are studied to create knowledge in Malaysian context. The study aims to provide better understanding on the development of marine current energy in the Straits of Malacca. The site selection, turbine de-sign, maintenance, power transmission, environmental impacts and cost reduction are studied, whereas the berthing load to harbour and wake-induced load to waterways are also investigated. The project enhances the knowledge of marine renewable energy in Malaysia and provides so-lution to the potential damage due to ship berthing in harbours. Queen’s University Belfast (Dr. GA Hamill, Dr. DJ Robinson) Methodology The computational, experimental and field studies are used to investigate the problems of marine renewable energy (MRE) and waterways protection. The free Computational Fluid Dynamics package (OpenFOAM) is used as a cost-effective approach. Possible High Impact Journals for Publications 1. Ocean Engineering (Q1 in JCR 2011, Civil Engineering Discipline) 2. Coastal Engineering (Q1 in JCR 2011, Civil Engineering Discipline) 3. Renewable & Sustainable Energy Reviews (Q1 in JCR 2011, 2011 Energy & Fuel Disci-pline) 4. Energy (Q1 in JCR 2011, 2011 Energy & Fuel Discipline) 5. Energy Conversion and Management (Q1 in JCR 2011, Mechanics Discipline) 6. J Atmos Ocean Tech (Q1 in JCR 2011, Ocean Engineering Discipline) 7. Ocean Modelling (Q1 in JCR 2011, Ocean Modelling Discipline) University of Plymouth (Dr. Ming Dai) Dalian University of Technology (Dr. Ming Jia, Dr. Jiafei Zhao) 121 122 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/48 Title: Study Of Partial Discharge Characteristics Within Voids In Dielectric Materials With Nanofillers Principal Investigator: Dr. Hazlee Azil Illias Department: Electrical Engineering Summary of Research Proposal Partial discharge (PD) may cause breakdown of an insulation material when the repetition of PD events within a defect is very high, which causes chemical and physical deterioration of the in-sulation. When breakdown of the insulation occurs, breakdown of the whole high voltage com-ponents may occur. To study a new insulation system, a dielectric material filled with nanofiller is proposed. Nanofillers studies have been on-going since the last decades. However, research on PD characteristics within a void in a nanofiller/dielectric material is not widely published. Therefore, in this project, measurement of PD activity will be performed on test samples consist-ing of a void in an epoxy resin filled with different nanofillers. A model of a void in a solid dielec-tric insulation material filled with nanofillers will also be developed using finite element analysis (FEA) software. The model will be used to simulate PD activity within a void in a nano-filler/ dielectric material and is compared with the measurement results. Comparison between measurement and simulation results will lead to a new knowledge on how partial discharge ac-tivity is influenced by the introduction of nanofillers in a dielectric material. New parameters from the simulation model, which play significant roles in affecting partial discharge behaviour, can be identified. Objectives Methodology 1. To attain a better understanding of PD within voids in nanofiller/dielectric insulation material 2. To develop a simulation model of PD activity a void in a solid dielectric material using FEA 3. To compare the influence of different nanofiller within epoxy resin on PD characteristics 4. To investigate the influence of the different void conditions on PD events in nanofiller/epoxy resin insulation material Once research background has been done sufficiently, a model geometry of a void located in a solid dielectric material filled with nanofillers will be developed using COMSOL Multiphysics software. The model will be used to simulate electric field distribution in the model geometry and PD activity occurring within the void. Once the model that has been developed can be simulated successfully and the simulation results are reasonable, experiments are ready to be performed in the high voltage laboratory. Initially, test samples for PD activity measurement will be built. The test samples will consist of a spherical void of various sizes and positions located in a nanofiller/dielectric material. In the experiment, the materials that will be used are Alumina/epoxy resin and Silica/ epoxy resin. Different conditions of the PD experiment that will be performed on the test objects are variation in the applied voltage amplitude, applied frequency, material temperature, void sizes and different density, dispersion and types of nanofiller within the material. After experiments 5. To identify key parameters from the FEA model that influence PD behaviour within a void in nanofiller/ dielectric materials through comparison between simulation and measurement have been performed, simulation of PD activity within voids will be performed to reproduce measurement results that have been obtained from the experiment. In this step, the model that has been developed in COMSOL Multiphysics software will be inter-faced with a MATLAB programming code for a better flexibility in handling the model. Outcome 1. How does partial discharge phenomenon behave within a void in a dielectric material l filled with nanofillers under different conditions of stress and void 2. How is partial discharge behaviour within a void in an insulation material of power cable geometry filled with nanofillers High Impact Research Annual Report 2012 Possible High Impact Journals for Publications 1. IEEE Electrical Insulation Magazine 2. IEEE Power and Energy Magazine 3. International Journal of Electrical Power and Energy Collaborators Prof. George Chen, Electrical Power Group, University of Southampton, United Kingdom Dr. Azrul Mohd Ariffin, Universiti Tenaga Nasional, Malaysia Assoc. Prof. Dr. Zulkurnain Abdul-Malek, Universiti Teknologi Malaysia, Malaysia Project No: UM.C/625/1/HIR/MOHE/ENG/49 Title: Central Advanced Research Enabler Facility (CAREF) Principal Investigator: Associate Prof. Dr. Faisal Rafiq Bin Mohamd Adikan Department: Dean Office Summary of Research Proposal This is a proposal for the setting up of an advanced engineering research ENABLER facility in the Faculty of Engineering. The facility will be a focal point for several flagship Ministry of Higher Education funded High Impact Research (MOHE HIR) projects, providing a common enabler platform for researchers to push research onto another level of complexity. The vision is that the Faculty’s flagship researches such as biomedical engineering, photonics, advanced microelectronics, and renewable energy, involving technologies such as biosensors, MEMs, microfluidics, integrated optical chips, solar panels and harvesters, would benefit from a common facility which would otherwise be obtained via separate funds. The facility will be a central lab, administered by Faculty appointed members of staff. Objectives Methodology Collaborators To avoid duplication and researchers working in silos, the Faculty proposes a central enabler facility that would result in these projects gaining access to similar essential equipment. To have an advanced laboratory equipped with cleanrooms facility Not Applicable The objectives of such facility are: 1. To attract first class students and good external candidates. 2. To attract collaborations and consortium. 3. To encourage highimpact publication and IP generation. 4. To provide international standard teaching and professional training facility. Outcome An advanced laboratory. Possible High Impact Journals for Publications Publications within the field of biomedical engineering, photonics, advanced microelectronics, and renewable energy, involving technologies such as biosensors, MEMs, microfluidics, inte-grated optical chips, solar panels and harvesters. 123 124 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/ENG/50 Title: Physiological Control of an Implantable Rotary Blood Pump. Principal Investigator: Dr. Lim Einly Department: Engineering. Summary of Research Proposal One aspect of continuous flow rotary blood pumps (RBPs) that is still in its infancy is its appro-priate control to cater for variations in metabolic demand and hence cardiac preload. In order to maximize the quality of life of the implant recipients so that they could regain a normal lifestyle in a long term unsupervised environment, it is believed that a pump control strategy which au-tomatically adjusts the pump speed to cater for changes in metabolic demand is needed. Objectives Outcome Collaborators The objective of the present project is to develop a control strategy that is to be able to adapt and respond quickly to varying metabolic demand normally encountered by the patients in real life, as well as to promote myocardial recovery. Development of control strategies that are to be able to adapt and respond quickly to varying metabolic demand normally encountered by the patients in real life, as well as to promote myocardial recovery. Siew Cheok Ng, University Malaya, Malaysia Possible High Impact Journals for Publications Chee Kok Han, University Malaya Medical Centre, Malaysia Methodology A mathematical model will be developed to evaluate the physiological interaction between the RBPs and the circulatory system under a wide range of operating conditions, using a numerical model, a mock circulatory loop and in vivo animal studies. The model will then be used to design and implement appropriate physiologically responsive control strategies for the RBPs. The performance of the control algorithm will be evaluated using the mock circulatory loop and in vivo animal studies. 1. IEEE Transactions of Biomedical Engineering 2. Artificial Organs Suhaini Kadiman, National Heart Institute, Malaysia Mohd Nazeri, National Heart Institute, Malaysia Nigel H Lovell, University of New South Wales, Sydney Socrates Dokos, University of New South Wales, Sydney John Fraser, The Prince Charles Hospital, Brisbane Daniel L Timms, The Prince Charles Hospital, Brisban High Impact Research Annual Report 2012 RESEARCH PROPOSAL (HIR-MoHE 4 Years) Faculty of Dentistry Project No: UM.C/625/1/HIR/MOHE/DENT/09 Title: Discovery of Single Nucleotide Polymorphisms (SNPs) for Oral Cancer prognostication Using Genomewide Association Study (GWAS) and the Development of Protein Biodiagnostic Marker for Early Detection of Oral Cancer Principal Investigator: Associate Professor Dr. Chen Yeng Department: Dental Research and Training Unit, Faculty of Dentistry Summary of Research Proposal Cancer association studies comparing frequencies of genetic polymorphisms between cases and controls, offer a powerful approach to identify variants. A genome wide association study (GWAS) approach proposed in this study allows the use of high throughput technologies towards identifying novel regions/markers and pathways associated with carcinogenesis by screening through genetic markers of 100,000 or more across the entire human genome using a large number of specimen. In an effort to increase the specificity of the diagnosis of OSCC, a concurrent study using an immune-proteomic approach will be an extension of the main project to look for significantly reliable biomarker(s) or a diagnostic test that individually or in combination with other markers for oral cancer detection and/or monitoring its progression. Besides these, the findings will also lead to the discovery of some basic but interesting information on functional cellular processes in human host systems towards cancer cells. Objectives Methodology With the use of high throughput technologies, we aim to detect single nucleotide polymorphisms (SNPs) in oral cancer patients and normal control and identify allelic polymorphisms which are associated with oral cancer. In concurrent with this, through proteomics and immunological ap-proach, we aim to detect immunogenic host tumor protein using human antibodies, and identify those differentially glycosylated proteins, and the proteins which have possible links to oral can-cer. We also hope to identify potential protein marker(s) for oral cancer progression and its ef-fectiveness and also to confirm and compare the common protein biomarker(s) of oral cancer progression using whole human saliva, serum and tissue. And lastly, we hope to identify new binding partners, binding affinities, the kinetics of binding and understand the function of the selected protein. A GWAS in 30 Malaysian oral cancer patients and 30 healthy controls obtained from Oral Can-cer Research & Coordinating Centre (OCRCC) will be conducted. These samples will be se-quenced using exome sequencing. Identification and correction for population stratification for quality control will then be conducted. The association between each SNPs identified and oral cancer will be assessed using a suitable statistical method. After the identification of the lead SNPs; the exons, the 3’-UTRs and the promoter will be sequenced in a subset of samples. The protein and immunological studies will be conducted with saliva, serum and tissue samples of oral squamous cell carcinoma (OSCC) samples which will be obtained from OCRCC. In attempts to investigate potential biomarker(s) of OSCC, two dimensional electrophoresis (2DE) followed by Western blotting of the three samples from affected individuals and normal healthy individuals will be compared. Characterization of those proteins of interest will later be subjected to mass spectrometry analysis using MALDI-TOF TOF. Physiologically relevant proteinprotein interaction studies will be carried out on those selected proteins using a Coimmunoprecipitation (Co-IP) technique. And finally the protein of interest will be isolated and crystalized to confirm the changes of structural conformation. 125 126 High Impact Research Annual Report 2012 Outcome Collaborators From this study we hope to be able to identify biomarkers on SNPs profile for genetic variation on oral cancer and be able to establish biomarkers for prognostication that could benefit the clinical management of oral cancer patients in the longer term. We hope the findings could be applied in diagnostic and targeted drug therapy for personalized medical treatment. Prof. Dr. Rosnah Mohd Zain, Department of Oral Pathology, Oral Medicine & Periodon-tology, Faculty of Dentistry, UM Possible High Impact Journals for Publications 1. Molecular and Cellular Proteomics 2. International Journal of Cancer 3. Oral Oncology 4. Head & Neck 5. Cancer Epidemiology, Biomarkers and Prevention Dr. Marhazlinda Jamaludin, Faculty of Dentistry, UM Dr. Thomas George, Department of Oral Pathology, Oral Medicine & Periodontology, Faculty of Dentistry, UM Karen Ng Lee Peng, Oral Cancer Research & Coordinating Centre (OCRCC), Faculty of Dentistry, UM Wan Maria Nabillah Wan Abd Ghani, Oral Cancer Research & Coordinating Centre (OCRCC), Faculty of Dentistry, UM Dr. Ha Kien Onn, Oral Maxillofacial Surgery, Faculty of Dentistry, UM Prof. Naoyuki Kamatani, RIKEN Center for Genomic Medicine, Japan MOH collaborators, Oral Health Division Ministry of Health Malaysia Project No: UM.C/625/1/HIR/MOHE/DENT/10 Title: Nutrigenomics and phospholipid signalling in oral cancer: Nutrient-gene interactions Principal Investigator: Professor Ian Paterson Department: Dental Research and training Unit, Faculty of Dentistry Summary of Research Proposal Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy reported worldwide. The global number of new cases is estimated at approximately 400,000 per annum, with about two-thirds of cases arising in developing countries. Although there have been significant improvements in chemotherapy and surgical techniques, OSCC is often particularly challenging to treat since most patients present with advanced dis-ease. The 5-year survival rate of around 50% has not improved in the past four decades. There is a compelling need to develop novel therapeutic strategies and to identify clinically relevant biomarkers to stratify patients for the most appropriate treatment. This is likely to be achieved only through a complete understanding of the specific molecular events that underpin the development and progression of the disease. High Impact Research Annual Report 2012 Objectives Methodology Outcome We will investigate which genes and pathways related to nutrient metabolism are deregulated in OSCC and examine the function of nutrient-gene interactions in the pathogenesis of OSCC. The role of two bioactive phospholipids, LPA and S1P, in the development and progression of OSCC will be analyzed in detail. We aim to identify how the expression of genes associated with phospholipid metabolism and signalling (enzymes, GPCRs, second messengers etc) are deregulated in OSCC and whether specific components of these pathways can be targeted therapeutically. Gene expression profiling will be used to identify genes and pathways related to nutrient metab-olism. The function of nutrient-gene interactions and the effect of LPA and S1P on the behaviour of OSCC cells will be examined using a variety of in vitro and in vivo assays of malignancy. To examine the specific function of individual genes we will use shRNA and lentiviral technologies to stably knock down gene expression. Therapeutic antibodies and chemical inhibitors of LPA and S1P signalling will be used to assess the potential of components of the phospholipid sig-nalling pathways as novel therapeutic targets for OSCC. New knowledge of genes that are involved in nutrient metabolism and how nutrients influence gene expression in OSCC. A fuller understanding of how bioactive lipids, LPA and S1P influence the development and progression of OSCC, how their signalling receptors are deregulated and how the lipid/ receptor axis might be targeted for the treatment of OSCC. Possible High Impact Journals for Publications 1. Journal of Nutrition 2. Oncogene 3. Journal of Pathology 4. International Journal of Cancer Collaborators Oral Health Division, Ministry of Health, Malaysia. Professor Paul Murray, University of Birmingham, UK. Dr Max Robinson, University of Newcastle, UK. Project No: UM.C/625/1/HIR/MOHE/DENT/11 Title: Optical Assessment of Enamel and Dentine Deand Remineralisation Principal Investigator: Dr Chew Hooi Pin Department: Department of Conservative Dentistry, Faculty of Dentistry Summary of Research Proposal Dental caries is a complex disease. Over the last several decades, a number of measurement criteria have been developed to identify the presence of dental caries. New diagnostic tools are needed for the characterization of dental caries in the early stages of development. If carious lesions are detected early enough, they can be arrested without the need for surgical interven-tion. Dentistry has shifted towards the concept of ‘Minimally Invasive Dentistry’ that allows maximal preservation of healthy tooth structure. However, caries prevention, caries arrest and preserva-tion of tooth structure are now possible with the advent of Adhesive dentistry. 127 128 High Impact Research Annual Report 2012 Objectives 1. 2. 3. 4. 3. Early Enamel Erosion (E1) • Translation of optical diagnostic methods into clinical use. Explore other novel objective decision-making aids. Establishing local prevalence data for general and erosive wear. Development of regional expert research team in oral hard tissue de- and remineralisa-tion. • The project is divided into 5 sub-projects and they are as delineated below: Methodology 1. Early Primary Enamel Caries (C1) • • 2. In vitro Characterization of Optical Coherence Tomography (OCT) data for fissure caries and Visualization of caries under restoration Scoring of teeth samples will be done according to ICDAS 0,1,2 followed by im-aging with digital radiography and OCT imaging before and after restoration placement(fissure sealant) and comparing with Gold standard PLM. Validation of the use of OCT in vivo in detection of primary and secondary caries. Dentinal Caries (C2) • Validation of the use of OCT in vitro in the determination of infected and af-fected dentine • In vivo validation of OCT technique in the longitudinal monitoring of early enamel erosion Optical coherence tomography measurements will be performed using the commercially available Thorlabs OCT system In vivo validation of Quantitative Lightinduced Fluorescence (QLF) in the longitudinal monitoring of early enamel erosion QLF analyses will be conducted following a set of predetermined rules (Pretty et al., 2002) in terms of patch placement. Detection of dentinal erosion in vitro using QLF and OCT. 4. Prevalence of Erosive Wear locally and its associated Risk Factor (E2a) 5. Validation of Longitudinal Monitoring of Erosive Wear with OCT (E2b) Possible High Impact Journals for Publications • Caries Research Journal • Journal of Dentistry • Journal of Dental Research • Journal of Community Dentistry and Epidemiology • Journal of Gastroenterology • Journal of Biomedical Optics Collaborators International Collaborators: Professor Angus Walls - University of Newcastle upon Tyne , UK Professor Roger Ellwood – University of Manchester, UK Professor Iain Pretty - University of Manchester, UK Dr Christian Zakian - University of Manchester, UK Co Researchers: Datin Dr Rashidah Esa Dr Maria Angela Garcia Gonzalez Outcome Dr Azwatee Aziz • Novel and Objective decision-making aid Dr Sadna Rajan • Reduce costs and discomfort for patients • Public Health monitoring tool • Stunting of the Restorative Cycle Dr Norasmatul Akma Dr Prema Sukumaran Dr Mohideen Salihu Farook Dr Erum Zain Dr Madiha Habib High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/DENT/12 Title: Quality of life assessment in dental practice: Assessing change in quality of life using the Oral Health Impact Profile by establishing the Minimal Importance Difference (MID) Principal Investigator: Assoc. Prof. Dr. Roslan Saub Department: Department of Community Dentistry, Faculty of Dentistry Summary of Research Proposal The focus of health care has shifted from being disease oriented to emphasizing wellness and the maintenance of the quality of life of the patients and population. This has led to change in the approach of care from being clinician-centered to patient-centered care. As such, clinical assessment alone has no longer sufficient to ensure quality care. Thus, dental practitioners should include assessment that captures patients’ concerns. One such measures available and can be used for the Malaysian population is S-OHIP (M) 1. This measure has been widely used in epidemiological and clinical research. However, such measure has not been widely used in clinical practice since there are very limited studies that have been conducted to assess the ability of this measure, especially in detecting change in dental practice. As a health care pro-vider, we would like to see our patient recovers from the disease and more importantly improves their quality of life as a result of the therapy rendered. However, despite the wide acceptance and use of OHRQoL measures, interpreting changes in OHRQL after therapy remains a chal-lenge to both investigators and clinicians. To be effectively used these measures in dental prac-tice we require a clear guidelines on how to interpret such measure especially to detect change. Researchers have suggested that the most effective way of describing and interpreting change in OHRQL is through the establishment of what is known as minimal important difference (MID)2. Objectives Methodology Outcome 1. To assess oral health-related quality of life (OHRQoL) among the partially edentulous patients before and after providing a new partial denture. The minimal important difference (MID) value for the partial denture rehabilitation therapy will be established, to be used in the clinical practice and also clinical research. 2. To assess the voluntary bite force of the patient before and after providing partial den-ture. A purposive sample of the partially dentate adult patients will be selected from Faculty of Dentistry Universiti of Malaya, Universiti Teknologi Mara (UiTM) and Universiti Sains Islam Malaysia (USIM). Patients will be given the S-OHIP(M) to be completed. Voluntary bite force and chewing performance will also be recorded. S-OHIP(M) will be administered again and voluntary bite force and chewing performance will be recorded after completion of the treatment at a follow-up clinic visit 4-6 weeks thereafter. In addition to that, the global transition scale will be also admin-istered to perform the anchor based technique. Data analysis will be done using distribution based and anchor based technique with global transition scale and voluntary bite force as an-chors. 3. To establish an estimate of MID of S-OHIP (M) in dental patients, in order to facilitate its interpretability. Possible High Impact Journals for Publications 1. Community Dentistry and Epidemiology 2. Quality of Life 3. Community Oral Health Collaborators Universiti Teknologi Mara (Dr. Tengku Fazrina bt Tengku Mohd Ariff, Pn. Rohaya Rah-man) Universiti Sains Islam Malaysia (Dr. Norlela Yacob, Pn. Ummu Anisah bt Abdul Rahman) 129 130 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/DENT/13 Title: Study of the Craniofacial Form of the Normal And with Anomalies of Malaysian Population using 3-Dimensional Imaging Principal Investigator: Associate Professor Dr Siti Adibah Othman Department: Children’s Dentistry & Orthodontics Summary of Research Proposal Visualization and analysis of craniofacial features of patients are involved in diagnosis and treatment planning particularly in the field of orthodontics. Due to several limitations of the con-ventional methods, three-dimensional techniques such as 3D CT scan, laser surface scanning and stereophotogrammetry has been explored. Planning an improvement of craniofacial anomalies patient’s facial appearance requires guide-lines on some kind of general set of facial proportions. This approach is practical in identifying the need of surgical correction in patients with anomalies after comparative assessment is performed according to the norms established for specific group. Objectives Methodology Outcome 1. Target population would include the cleft lip and palate patients attending the Combined Cleft Lip and Palate Clinic at Faculty of Dentistry ,University of Malaya. For Down’s syndrome patients, visit to the Down’s syndrome centre will be planned for sample collection. Patients with other abnormalies who come for treatment at Dental Faculty will also be included. For normal subjects, it will be recruited from the normal walk –in patients attending the clinics at the Faculty of Dentistry, University of Malaya. All 3D facial scans were captured using the M5 Cranio 360 Vectra 3D Face System (Canfield Scientific Inc). The captured images were then displayed and analyzed using 3D Mirror Software. Establishment of anthropometric norms related to craniofacial region for the Malaysian population. 2. 3. To obtain quantitative information concerning the three-dimensional (3D) arrangement of the craniofacial features of subjects with craniofacial anomalies in Malaysia To compare the craniofacial features of craniofacial anomalies patients with normal sub-jects in Malaysia To develop a database that will store all 3D images of the study subjects with craniofacial anomalies in Malaysia. Derive useful guidelines in the treatment of patients with craniofacial anomalies. Possible High Impact Journals for Publications 1. Journal of Dental Research 2. Clinical Oral Investigation Research 3. Journal of Medical Image Analysis 4. IEEE Transactions on Medical Imaging 5. Journal of Bioinformatics High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/DENT/14 Title: Optimization Of Fabrication Techniques For Novel Functionally Graded Dental Post And Its In-Vitro And InVivo Evaluation Principal Investigator: A/P Dr. Hadijah Abdullah Department: Conservative Dentistry, Dental Faculty Co-Principal Investigator: Prof. Dr. Noor Hayaty Abu Kasim Department: Conservative Dentistry, Dental Faculty Summary of Research Proposal Endodontically treated teeth restored with dental posts tend to be susceptible to root and coronal fracture during function. Commercially available posts are either rigid or flexible along its length as they are fabricated from homogenous materials. The ideal post would be one that exhibits different properties at the different length of the tooth, from the coronal to the apical region. Three novel formulations of functionally graded dental posts system has been patented. These dental post matches the high stiffness at the coronal region and its stiffness gradually reduced apically. A study on these prototypes functionally graded dental posts (FGSP) in extracted bo-vine teeth showed that FGSPs exhibited several advantages in terms of stress distribution and fracture resistance compared to posts fabricated from homogeneous material. ‘Functionally graded materials’ approach has been shown to be useful in designing a new gen-eration of new dental post. However, the optimum fabrication technique has to be identified to produce FGSPs of suitable sizes for the human dentition in a commercial scale. Objectives Methodology Outcome Biocompatibility, optimization of fabrication technique, fracture resistance and fracture mode of novel FGSPs will be compared to their commercial counterparts. The bond strength when cemented with various luting cements in extracted human teeth and thermal properties will be evaluated. The treatment outcome of these new post used to restore in single rooted teeth need to be studied in a clinical trial. Fabrication of novel dental posts based ZrO2, Ti, Al2O3 and HA powders, through drying blending, mixing and milling process. Optimization of fabrication technique either using microinjec-tion moulding or diamond grinding will be evaluated. The biocompatibility and toxicity will also be evaluated. An invitro study on 100 root treated extracted upper incisors will be carried out to investigate the fracture resistance, thermal properties, bond strength and mode of failure. The boding strength will be then evaluated. Finally the survival rate of these new functionally graded dental posts will be evaluated clinically. A novel dental post systems for the restoration of endodontically treated teeth. One PhD and one Master students Possible High Impact Journals for Publications 1. Journal of Dental Research 2. Dental Materials 3. Journal of Dentistry 4. Interntional of Endodontic Journal 5. Journal of Endodontics 6. Biomaterials Collaborators Prof. Dr. Hien Ngo, Faculty of Dentistry, Kuwait University, Kuwait BTS Distribution Germany (Industry partner) 131 132 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/DENT/15 Title: In vitro microbiological and tissue culture studies for healthcare products Principal Investigator: Assoc Prof Dr Fathilah Abdul Razak Department: Oral Biology Summary of Research Proposal The oral cavity is a dynamic ecosystem consisting of both biotic and abiotic components that interact between them in a balance manner under the normal, healthy condition. In such a dy-namic relationship, alteration to one of its component may often disturb the other and eventually if left unattended, may lead to the onset of oral diseases such as dental caries and periodontal diseases. The use of oral health care products has become a necessity to maintain the health of the mouth. The increase in awareness of the public against the use of chemicals and alcohol in oral health care product has created an opportunity for research involving natural resources. The develop-ment of such products for human consumption however needs to meet certain requirement. Confirmation and validation on the safe use of compound/s obtained from these natural resources must be based on sound scientific data. For that, relevant laboratory testing and clinical trials need to be carried out to produce supporting data and provide adequate information before a compound can be promoted as an active component in oral health care products. Objectives Methodology The study aims to evaluate the effect of extracted compounds from various local plants on the oral ecosystem and with the information gathered, formulate extract-based preparations with antiplaque/antifungal/salivastimulating/anticancer/wound healing activities that can be used to maintain oral health. At the early stage, the biological properties of these extracts and compounds which includes pH, fluoride content, phenols content and the stability (selves-life) of the extracts on storage are being determined. Studies on their antibacterial and antifungal activities will then follow to explore the effect of the extracts and compounds on the microbial component of the dental plaque. During the initial stage of dental plaque formation, adhesion of microorganisms to the tooth sur-face is important to ensure colonization of the tooth surface is secured. Thus the effect of the extracts/compounds on the adhering properties of both oral bacteria and candida to saliva-coated hard surfaces will be looked into. An extract/ compound that is able to deter colonization of these microbes to the hard surface would be promoted as an antiplaque agent. Other proper-ties that are of interest include to study the responses of soft oral tissue to the ex-tracts/compounds and this work will involve the use of oral cell lines and tissue culture tech-niques. The effect of the extracts/compounds on both oral cancer cells and normal oral fibro-blasts will be used to indicate the responses of oral cells on exposure to the extracts/ compounds. Other aspects of interest include responses of oral fluid such as saliva in the presence of the respective extracts/compounds. Finally the collected data will be used to formulate various preparations for the purpose of oral health maintenance. High Impact Research Annual Report 2012 Outcome A comprehensive approach in the search of active compounds for use as adjuncts in oral health care products is important considering the dynamic interactions between the various compo-nents in the oral ecosystem. The integration of collected data obtained from various aspects of the study will be systematically analyzed to produce oral health care products that are effective. Possible High Impact Journals for Publications 1. Journal of Dentistry 2. Journal of Oral Diseases 3. Antimicrobial and chemotherapy journal Collaborators Natural Product Research Centre, UiTM Puncak Alam Project No: UM.C/625/1/HIR/MOHE/DENT/16 Title: Microscopy and Physiological Studies on the Effect of The Oral Healthcare Products on The Oral Ecosystem Principal Investigator: Prof Madya Dr Marina Mohd Bakri Department: Oral Biology, Faculty of Dentistry Summary of Research Proposal The formation of biofilms is a natural process and can be controlled through regular toothbrush-ing to prevent the formation of dental plaque which is associated with the development of caries and periodontal diseases. A formulated oral health product containing local plant extracts with antibacterial properties will be tested for its effects on teeth and tissue culture models as this will be crucial before the product can be used by the public. The bacterial protein responsible for the interaction between the bacteria and the host during biofilm development will be anlysed in this study. The formulated oral health care product will be also be tested for its side effect on tooth specimens. Objectives Methodology 1. To determine the effects of a formulated oral health care products on teeth, 2. To determine the effects of a formulated oral health care products on the expression level of dysregulated genes in ORL48 and KB cancer cell line, Preparation of selected local plant extracts will be carried out using the boiling method. Saliva from patients will be collected before the start of the experiment and after using the mouthwash for two weeks. Patients will be required to rinse for 20 seconds, twice a day for two weeks and the collected saliva be used for assessment of enzymes tests. 3. To determine the salivary enzyme activity of patients exposed to the formulated oral health care products. The selected plant extracts will be tested on two oral squamous cancer cell line (OSCC) types; ORL 48 and KB cell line. Extracts of different plants will be tested for it’s cytotoxic effects on the cell lines using the Neutral Red Assay. Optimum concentration of the cytotoxicity test will be a parameter for downstream procedure that would be revolving around the analysis of gene regu- lation. Besides that, five different genes of five particular cancer pathways and two housekeeping genes were selected to be analyzed for its regulation using qRT-PCR. Outcome Better understanding of the effect of the oral health care products on the cancer cell lines and when consumed by patients. 133 134 High Impact Research Annual Report 2012 Possible High Impact Journals for Publications 1. Planta medica 2. Journal of ethnopharmacology 3. Anti microbial and environmental microbiology 4. Journal of oral microbiology 5. Critical review of oral biology. Collaborators Dr Wan Himratul Aznita bt Wan Harun Prof Dr Zubaidah Haji Abdul Rahim Assoc Prof Dr Fathilah Abdul Razak Dr Sarni Mat Junid Puan Zubaidah Abu Hassan Prof Dr Richard Cannon Assoc Prof Dr Alison Rich Dr Ann Holmes Project No: UM.C/625/1/HIR/MOHE/DENT/17 Title: Effect of Plant Extracts on the Expression of Genes Responsible for the Colonisation of Dental Plaque Microorganisms. Principal Investigator: Dr. Wan Himratul Aznita Binti Wan Harun. Department: Department of Oral Biology, Faculty of Dentistry Summary of Research Proposal The pathogenesis of oral candidiasis is closely dictated by the formation of biofilms of Candida species in the oral cavity. Candidal adherence on the host surfaces is known as the first step for candida colonization, and becoming more resistant to antifungal agents including amphotericin B, fluconazole and itraconazole. The ability of Candida spp. to switch from unicellular yeast to long and continuous tubules hyphae has been considered as an important factor for the interactions with host. The increasing bacterial resistance to conventional antimicrobial agents has lead many researchers to search for natural products with antimicrobial activity including the ability to reduce bacterial colonization resulting in reducing dental plaque formation. Combination therapy is one approach that can be used to improve the efficacy of antimicrobial therapy. Our previous studies have shown that seven oral candida species namely C. albicans, C. dubliensis, C.glabrata, C.krusei, C.lusitaniae, C. parapsilosis and C.tropicalis were highly susceptible to the aqueous extract of P. betle. In this study, purified hydroxychavicol from P. betle was evaluated in vitro against a selected group of oral cavity pathogens. Objectives This project was design to identify the genes of dental plaque bacteria which are affected as being demonstrated by the reduce colonization ability following exposure to the local plant extracts. In this project, we explored the antifungal activity of hydroxychavicol against medically important Candida spp, and examine the synergistic effects when hydroxychavicol is combined with commonly used antifungal agents. Our studies also addressed to study the pathogenicity of hyphal transition form of selected Candida spp. through investigation of their biological characteristics and molecular genetics. High Impact Research Annual Report 2012 Methodology Outcome Active compound was purchased from Sigma Aldrich and the Minimal Inhibition Concentration (MIC) and Minimal Bactericidal (MBC) was determined and validated according to the microdilution method of the CLSI (formerly NCCLS) (M27-A). Seven strains of Candida species, in this study are purchased from The American Type Culture Collection (ATCC), USA. For hyphal transition study, serum in combination with YPD as growth media was used as the induction agent. Morphological changes were observed through light and electron microscopy. Susceptibility of yeast and hyphae form against antifungal agents was tested using microdilution broth method. Hyphal development study was carried out using germ tube formation test through microscopy and spectrophotometry. Synergistic effect of antifungal agent in combination with commercialized drug (Amp B) against Candida spp. was performed using microdilution method and effect of antifungal agent on the ultra structure of Candida spp. will be studied through microscopy and spectrophotometry analysis. Gene expression will be determined through quantitative PCR. Screening for antifungal activities on several local plants which include Piper betle, brucea javanica, ginger, galangal, garlic, henna, shallot, tarragon were carried out, and it was found that Piper betle, brucea javanica, garlic, shallot and tarragon’s aqueous extract exhibited antifungal activities towards all seven candidal strains tested in the study. Following that, the positive extracts have been sent for bioactive profiling to determine the bioactive compounds. Meanwhile, bioactive compound of hydroxychavicol from Piper betle exhibited an inhibitory effect on all seven candidal strains tested (MICs of 31.25 to 1000 μg/ml) with a minimal fungicidal concentration which was twofold greater than the inhibitory concentration. Hydroxychavicol showed a potent antifungal effect in combination with Ampothericin B which is FIC value is <0.5 for C.albicans, C.glabrata and C.tropicalis. This study has also showed C.albicans, C.parapsilosis and C.tropicalis to be positive for germ tube formation when induced in 50% Fetal Bovine Serum (FBS) (v/v) of Yeast Peptone Dextrose (YPD) broth media at 37°C. The filamentous form was more resistance relative to the normal yeast cells. Ability of yeast cells to form germ tube was inhibited and its growth rate has been reduced to approximately 30% by the antifungal agents’ activity of chlorhexidine gluconate. In concise, study has shown that transition activity of Candida cells contribute to its resistance towards antifungal agent. Possible High Impact Journals for Publications 1. Journal of Molecular Microbiology and Biotechnology 2. Oral Microbiology and Immunology 3. International Dental Journal 4. Phytomedicine 5. Journal of Ethnopharmacology Collaborators Faculty of Medicine, UM Faculty of Applied Science, UiTM 135 136 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/DENT/18 Title: Assessing the oral health needs of Malaysian indigenous population and development of a new dental health education strategy Principal Investigator: Dr. Nor Himazian Mohamed Department: Department of General Practice and Oral and Maxillofacial Summary of Research Proposal Oral health is integral to overall health and wellbeing, with poor oral health and untreated oral conditions having a deleterious impact on quality of life. Oral health problems such as caries, periodontal disease, gingivitis, dental abscess and oral mucosal abnormalities may cause a great deal of pain and distress among population especially in children. If left unattended they may result in severe problems with eating, growth, speech, and behaviour. Malaysian indigenous comprised of the Orang Asli in the West Malaysia. Majority of them live in the remote and some in the fringe urban after rehabilitation plan. Some of them accesses public dental services either by static dental clinic or mobile dental squad providing by the gov-ernment of Malaysia. Oral health status relates to common oral health diseases and the more severe ones which relate to cancer and dental-facial pain. Available studies have shown there is a changing trend in diseases prevalence between the indigenous who are rehabilitated into the mainstream and those who are remained to lead the traditional lifestyle. Despite the advancement in dental treatment and technologies, the indigenous group tended to receive less oral health care compare to the general Malaysian population due to their attitudes, locations (accessibility) and lack of oral health literacy. Dental exposure and education of the indigenous children and parents with regards to prevention is essential. In oral health con-text, literacy can be considered as the skills necessary for people to understand the causes of poor oral health, to learn and adopt fundamental aspects of positive oral self-care behaviours, to communicate with oral health care providers, to place their names on dental treatment waiting lists or organize appointments, to find their way to the dental clinic, to fill out the necessary forms and to comply with any required regimes, including follow-up appointments and compliance with prescribed medication. Oral health literacy is required to promote oral health and to prevent oral disease. It has also been proposed that health literacy may be associated with barriers to accessing care, oral health behaviours such as prevention and to follow-up care Objectives 1. To collect data on the oral health status of children and adult of indigenous group in Be-lum, Perak and other parts of Perak and thus determine their treatment needs. 2. To assess the dental knowledge and attitudes of indigenous children’s and parents/carers. 3. To assess the effects of poor oral health towards indigenous children nutritional intake, body Methodology weight, growth and quality of life. 4. To determine the problems and impact of oral facial pain on their quality of life. 5. To develop a new Dental Health Education package 1. Research approval from Medical Ethics Committee of Faculty of Dentistry, University of Malaya and Jabatan Hal Ehwal Orang Asli Malaysia 2. Several visits and clinical examination of the Orang Asli in Belum, Perak and other parts in Perak will be conducted. Prior arrangement and communication with Jabatan Hal Ehwal Orang Asli and Tok Batin incharge of the area will be sought out before the visit. High Impact Research Annual Report 2012 3. 4. 5. 6. For all cases, consent will be obtained from the participants or their parents. Sociodem-ographic information and data about oral care habits and previous visits to dental services will be gathered from the participants/ parents. Data on dental knowledge and attitudes will be obtained through interviews by the investigators. Questionnaire survey will be conducted on oral problems and impact of facial pain on their quality of life. For children, body weight and height will be measured and compared to the WHO child growth standards and as well child growth charts from Malaysian studies. Clinical oral examination will be carried out to determine the oral health status by assessing the following: a. DMFT/dmft and treatment needs b. Oral hygiene index and Community Periodontal Index (CPI) 7. 8. c. Plaque score at 4 sites per tooth (for children) Possible High Impact Journals for Publications d. Bleeding on probing (BOP) at 4 sites per tooth (for children) 1. Asia-Pacific Journal of Public Health e. Oral mucosal lesion (for adult) 2. Community Dental Health 3. Community Dentistry and Oral Epidemiology 4. Journal of Dental Education 5. International Journal of Paediatric Dentistry Dental photography, 3D Imaging and impression will be taken among the adults and children above 7 years old.. Dental cast will be fabricated subsequently. Assessment of the oral health literacy from the questionnaires. Collaborators Ministry of Health Malaysia Outcome Data collection on the oral health status and the survey will provide informations to the Jabatan Hal Ehwal Orang Asli Malaysia and the Ministry of Health Malaysia on their treatment needs. Thus getting them some projections on expenditure in provision of dental services to orang asli group in Malaysia. Dental education package developed at the end of the research will be useful as a teaching aid for the target group. Project No: UM.C/625/1/HIR/MOHE/ DENT/19 Title: Anatomical structural variations in the maxillofacial region Principal Investigator: Prof Dr Phrabhakaran Nambiar Department: Faculty of Dentistry Summary of Research Proposal The oral cavity is an important area as it has a sgnificant role in mastication, esthetics, speech, respiration and facial growth of an individual. With increased rehabilitation of this area, there is a need to find whether there are any anatomical variations of structures of this area. These include determination of root and canal morphology of teeth, variations in position of the nerves, structural variations of bony supporting tissues and the topography of the floor of the maxillary sinus. We also intend to extend the research to include the study of teeth of Orang utans. Skulls of these primates (obtained with permission from Zoo Negara) will be imaged and the necessary measurements taken. Subsequently metrical and non-metrical relationship with human teeth and the supporting structures will be studied to see any genetic affinity. 137 138 High Impact Research Annual Report 2012 Objectives Methodology Outcome 1. To determine the variations of antomical structures in the maxillofacial region. 2. To provide accurate metrical measurement of some anatomical structures and their standard deviations. 3. To determine if there are any variations because of gender, race and ageing process. Clinical application of this new knowledge will useful during the treatment of patients. Particularly it will be relevant when performing dental implantology, root canal treatment or surgical procedures in the maxillofacial region. Root canal morphology of Orang utans might reveal similarity to human root canal system. 4. To study in detail root and canal morphology of Orang utans and find any similarity with human dentition. These studies are possible because we have images of patients recorded by two ConeBeam Computed Tomography (CBCT) machines at the Faculty of Dentistry. These machines provide high quality image resolutions and measurements are metrically accurate. We have also devised a novel method to image individual teeth so that it is possible to make detailed studies of them. Orang utan skulls obtained from Zoo negara will be images for detailed study of their root and canal morphology. We also have the SimPlant software which allows the viewing of the axial, cross-sectional, panoramic and 3D visualization of the jaws in the same screen on the computer monitor. Possible High Impact Journals for Publications 1. Journal of dental research, 2. Journal of veterinary dentistry, 3. Journal of anatomy, 4. Journal of Morphology, 5. Clinical antomy. Collaborators NA Project No: UM.C/625/1/HIR/MOHE/DENT/20 Title: Study of host immunogenic and post-translational modified proteins in schizophrenic patients and oral health condition of the patients. Principal Investigator: Associate Professor Dr. Chen Yeng Department: Dental Research and Training Unit, Faculty of Dentistry Summary of Research Proposal Schizophrenia is a pervasive neuropsychiatric disease of uncertain cause. It can affect both children and elderly but mostly seen in the age group of 15-35 years interfering the most pro-ductive period of life and resulting in prolonged suffering. Clinical presentation of schizophrenia is convoluted as there is no single symptom or symptom cluster is considered pathognomonic. The current diagnostic method for schizophrenia solely depend on the considerably subjective assessment of symptoms as there is no empirical method to validate the diagnosis of the disease and molecular mechanism underlying the disease yet to be fully understood. Therefore, it is important to reveal and understand the unknown of the underlying functional changes at cellular level; in spite of the fact that the disease involves interaction of multiple genetics and envi-ronmental risk factors. High Impact Research Annual Report 2012 Objectives Methodology By using a proteomics and immunological approach on serum of schizophrenic patients, we hope to identify potential protein marker(s) specifically for schizophrenic patients and those dif-ferentially N-glycosylated and O-glycosylated proteins expressed in the sera of schizophrenic patients as well as to investigate the correlation between schizophrenia and oral health of the patients to better understand the underlying mechanism of the disease. Protein profiles of the patients will be investigated, immunogenic and glycosylated proteins will be identified and analysed both qualitatively and quantitatively differences. Methods to be applied in the study include TwoDimensional Gel Electrophoresis, Western Blot, MALDI-ToF-ToF and ELISA. Outcome This study would also shed information on human distinctive immunology feature related to schizophrenia and as a mean to drive development of new diagnostic and therapeutic method. Possible High Impact Journals for Publications 1. PLOS One 2. Molecular and Cellular proteomics 3. Journal of Proteome Research 4. Proteomics Collaborators Associate Professor Dr. Ahmad Hatim, Department of Psychological Medicine, University of Malaya Dr. Emelia Osman, Department of Parasitology and Medical Entomology, Universiti Kebangsaan Malaysia. Project No: UM.C/625/1/HIR/MOHE/DENT/21 Title: Novel Tissue Expander To Facilitate Maxillary Expansion In Treating Crossbite And Transverse Maxillary Hypoplasia Principal Investigator: Prof. Madya Dr. Zamri Radzi Department: Children Dentistry And Orthodontics Summary of Research Proposal This proposal is to examine the use of a novel anisotropic tissue expander (1) as a medical de-vice that will significantly improve patient outcomes in the surgical treatment of crossbite, (2) improve our understanding of mucosal expansion (3) improve our understanding of maxillary bone development. Crossbite afflicts 7-10% of the Malaysian population. It is a condition where the widths of the dental arch bases are incorrect, and is very painful. A range of devices will be obtained, characterized and trialed in a sheep model. The optimized device will be trialed in a small scale human clinical trial. Concurrently, detailed observations from these in vivo studies will increase our understanding of soft and hard tissue development. Objectives 1. To obtain certain mechanical, physical and thermal characteristics of different types of the devices in order to correlate it with animal and clinical findings. 2. To assess the viability of a novel anisotropic tissue expander based on coated hydrogels for maxillary expansion. These series of studies are also designed to meet the regulatory requirements (specifically CE marking in the EU and FDA approval in the US) for a Class IIb medical device prior to commercialization activities of the novel tissue expand-er. 3. To assess the rate and direction of expansion of the novel tissue expander in the human maxilla and to evaluate the changes in dimension of the hard and soft tissues using Cone Beam Computed Tomography and to determine the long term stability of novel tissue expander. 4. To compare the novel method with current standard methods of expansion and assess patients’ acceptance and Quality of Life. 5. To determine the long term stability of novel tissue expander. 139 140 High Impact Research Annual Report 2012 Methodology Few different types of the devices and the biological tissues will be studied from the mechanical, physical and thermal point of view. Mechanical properties of the sheep palatal tissues and the swelling parameters generated by the expanders will be studied using Dynamic Mechanical Analyzer. Atomic force microscope will be used to characterize different ultrastructures in bulk samples for each set of palatal tissues. Materials’ composition, phase and form will be studied using Differential scanning calorimetry and differential thermal analyzer to ensure that it behave as intended for the purpose of process validation. All of the data obtained will be correlated with the animal and clinical findings. The 3R’s principles have been considered in every planned procedure. It is estimated that each group will consist of approximately 5 animals per treatment in order to obtain a significance level of 5% and a power of 80%. Approval will be sought from the Animal Care and Use Committee (ACUC) of the Faculty of Medicine, University of Malaya. A prospective control clinical trial will be carried out to compare the novel method with current standard methods of expansion. Suitable participant will be recruited following a strict inclusion and exclusion criteria. The participant will go through a similar procedure as the participant in case studies. The participants will be monitored longitudinally. In addition, the psychological, patients’ acceptance and Quality of Life will be assessed. Participants will be followed up for an assessment of short term and long term stability of novel tissue expander. Suitable patients will be screened at the Orthodontic New Patient Clinic, University of Malaya. Strict inclusion and exclusion criteria will be employed. Selected patients will be recruited to participate in the case study programme. Consent form will be obtained prior to the study. A prospective control clinical trial will be carried out to compare the novel method with current standard methods of expansion. Suitable participant will be recruited following a strict inclusion and exclusion criteria. The participant will go through a similar procedure as the participant in case studies. The participants will be monitored longitudinally. In addition, the psychological, patients’ acceptance and Quality of Life will be assessed. Participants will be followed up for an assessment of short term and long term stability of novel tissue expander. Outcome A novel tissue expander patented and will be used on crossbite and transverse maxillary hypo-plasia patients in Malaysia. 3 PhDs and 4 MSc graduate will be produced. Possible High Impact Journals for Publications 1. Journal of Dental Research 2. Biomaterials 3. Dental Material 4. Journal of Dentistry 5. Journal of American Dental Association 6. Clinical Oral Implantation Research 7. Journal of Material Science 8. Journal of Biomechanics 9. Journal of Periodontology 10. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology Collaborators David Jackson (Oxtex Limited, Oxford Centre for Innovation, New Road, Oxford OX1 1BY) High Impact Research Annual Report 2012 RESEARCH PROPOSAL (HIR-MoHE 4 Years) Faculty of Computer Science and Information Technology (FCSIT) Project No: UM.C/625/1/HIR/MOHE/FCSIT/08 Title: Human-Robot Interaction (HRI) Algorithm in Robotbased Intervention of Elderly with Alzheimer’s Disease Principal Investigator: Dr. Chan Chee Seng Department: Artificial Intelligence, FCSIT Summary of Research Proposal While robots have been used for social interaction, there is great untapped potential for their use as therapeutic social partners. This research provides a process by which a socially assistive robot can be developed and used as part of a therapeutic intervention for elderly with Alz-heimer’s disease (AD), elderly who have severe deficits in forgetfulness, depression and social withdrawal behavior. This work is focused on robots whose behavior encourages and facilitates social behavior in elderly with AD through embodied social interaction. Objectives Methodology 1. A novel robot architecture designs specifically for social intervention, examining the resulting humanrobot and human-human social behavior, and comparing that behavior to human-human social behavior will be proposed. In particular, effective and efficient algorithms for multimodal analysis and interpretation of human deceptive behaviour that can take into account non-linear correlations between multimodal cues (facial expressions, head and body gestures, and various vocalizations) in space and time will be investigated. 2. To explore how to employ swarm intelligence + particle filtering information to effectively represent a specific activity patterns and environments models. To explore how to reason fuzzy qualitative trigonometry + description logic to identify fa-cial segments for effective HRI. Outcome • Application: Human - robot interactions for elderly healthcare Possible High Impact Journals for Publications 1. IEEE Transactions on Fuzzy Systems 2. Pattern Recognition Collaborators Prof. Dr. Paolo Remagnino, University of Kingston, U.K. Dr. Dorothy Monekosso, University of Ulster, U.K. 141 142 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/FCSIT/09 Title: Efficient Green Operational Rescue Using Vehicle Ad Hoc Technology Principal Investigator: Dr. Rafidah Md Noor Department: Faculty of Computer Science and Information Technology Summary of Research Proposal A vehicular network is a kind of wireless networks that has emerged in wireless technologies and the automotive industry. Vehicular networks are formed between moving vehicles equipped with wireless interfaces that could be of homogeneous or heterogeneous technologies. These networks, also known as VANETs (Vehicular Ad-hoc Networks), are considered as one of the ad-hoc network real-life applications, enabling communications among nearby vehicles as well as between vehicles and nearby fixed equipment (roadside equipment). Vehicles can be either private, own by individuals or private companies, or public means of transport (e.g., buses, public service vehicles such as police cars, fire trucks, helicopters, trains, etc.). A rescue unit operation is a challenging experience in helping any incidents involved in urban areas and rural areas. The rescue unit team requires efficient and reliable communications for each operational rescue involved. The rescue unit team would be able to share an incident location, share the incident cases via video or voice streaming, forward a medical information, etc. A general architecture based on the concept of rescue unit community is developed. A vehicle area network is created through when the related equipments are connected inside the rescue unit vehicle. Each rescue unit vehicle will communicate in 1000 metres radius to create a Vehicle Ad Hoc Network (VANET). In specific scenario, such as urban (high density) areas, the rescue unit vehicles create a team and perform the operation rescue. Objectives Methodology The aim of this research project is to provide an efficient operational rescue unit in vehicular networks. There are four objectives to achieve: First, it aims to identify green metrics for operational rescue using vehicular networks. The study seeks to explore the operational rescue conducted in Malaysia. The interview data will be sup-plemented by the analysis of documents. Second, the project utilizes the green metrics as a measurement tool to identify the efficiency of the rescue operation. There are several steps tak-en to achieve this objective where the understanding of the vehicular technology such as physi-cal layer, data link layer and network layer. a. b. c. d. e. To investigate the operational tasks among the rescue units and identify their activities involve in the rescuing situations. To propose a framework that provides an efficient opreational rescue for different scenarios (i.e. urban and rural areas). To implement visualization system to access information enable rescuers to respond to the incidents more efficiently with better situational awareness. To implement a vehicular network testbed by using the wireless special equipments that provide real time communication among the rescue unit. To analyze the operational rescue through the green indicator performance. Outcome Better understanding of operation rescue in Malaysia through their generic model. Green metrics and development of routing algorithm can be used to measure the efficiency of the operation rescue. Possible High Impact Journals for Publications 1. IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY 2. IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS 3. TRANSPORTATION RESEARCH PART C-EMERGING TECHNOLOGIES 4. IEEE COMMUNICATIONS SURVEYS AND TUTORIALS 5. IEEE TRANSACTIONS ON MOBILE COMPUTING 6. AD HOC NETWORKS 7. IEEE WIRELESS COMMUNICATIONS Collaborators Dr. Chih Heng-Ke, Department of Computer Science and Information Engineering, No.1, University Rd., Jinning, Kinmen. Taiwan. Dr. Christopher Edwards, Lancaster University, United Kingdom High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/FCSIT/10 Title: Mirror Neuron and Quantum Mechanics Based Neural Architecture for Humanoid Principal Investigator: Prof. Dr. Loo Chu Kiong Department: Artificial Intelligence, FCSIT Summary of Research Proposal A grand challenge for robotics is establishing “friendly” and social interaction between robots and humans. Due to the diversity of actions/tasks to be performed and the range of possible interactions with objects and humans, it would be impractical (if not impossible) to explicitly pre-program a robot with such capabilities. Instead, such systems must be able to learn by themselves what tasks to execute and how they should be performed, which requires sophisticated motor, perceptual, and cognitive skills. In this project, we will address further challenge to apply the Quantum Mechanics based neural structure for humanoid. Objectives Methodology Outcome 1. We will use Darwin-OP humanoid and Nao H25 with laser head to realize self-localization and social communication with a human and robot-robot interaction. The robot has an embeded CPU and many sensors, such as a CCD camera, microphone which enable the robot to perform image processing (WP1), voice recognition, target tracking and imitative learning (WP3). In this project, the robots use perceptual modules for various modes of image processing, such as differential extraction, human detection, object detection, and human hand-motion recognition. We will use Microsoft Speech SDK for voice recognition and synthesis in the robot [8]. It was able to perform voice recognition using a sound segment network that made speaker-independent recognition possible. After that, the robot selects the conversation mode from: 1) scenariobased conversation; 2) usual conversation; and 3) learning conversation. Quantum mechanics based mirror neuron model for elderly assistive humanoid 2. To develop a quantum mechanics inspired neural architecture for online associative learning based on intentional interaction with humans by means of body gestures and visual information. To develop mirror neuron based online imitative learning model that abstracts the whole-body motions as symbols, generates motion patterns from the symbols, and distinguishes motion patterns based on the symbols. Possible High Impact Journals for Publications IEEE Transactions on Neural Networks and Learning System, International Journal of Neural Systems, Applied Soft-computing Collaborators Prof. Dr. Naoyuki Kubota, Tokyo Metropolitan University, Japan Prof. Dr. Hideyuki Takagi, Kyushu University, Japan Mr. Noel Tay Nuo Wi, Multimedia University 143 144 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/FCSIT/11 Title: Scientific Mapping and Research Assessment of STEM Scholarly Communications Principal Investigator: Assoc. Prof. Dr Abrizah Abdullah Department: Library & Information Science Summary of Research Proposal The assessment of research performance in the scientific disciplines has caught the attention of the university community for a long time. The most crucial asset of a university is its reputation, and research is the playing field where reputations are made. It is important to study trends in research productivity because universities account for basic research which is one of the main-springs of industrial innovations. The RM14.1b (USD4.2b) allocated to the Ministry of Higher Education in 2009 under the 9MP was a further indication of the importance that the govern-ment places on research. A systematic assessment of Malaysia’s research performance how-ever is not available. As such studying the performance and impact of Malaysia in very specific or emerging scientific fields against that of the world and and leading countries in the field need to be investigated through detailed evaluation technique of scholarly communication. Objectives Methodology The overall objective of this research is to scientometrically position the world’s performance in a broad and specific emerging STEM fields and how are the leading countries and Malaysia positioned in the studied areas. It also develops indicators or model to enable the production of statistics on STEM research productivity not yet defined by existing indexing systems. This research employs bibliometrics methods to derive new insight from existing databases of scientific publications. It uses mathematical formulas and statistical methods to analyse and measure the output of scientific publications. Within bibliometrics, scientometrics is used to measure scientific activity based on scientific papers. Outcome Reveals data that lead to a greater understanding of the impact of a particular scientific discipline on Malaysian science, technology, engineering and medicine (STEM) and position Malaysia’s output in the field against that of the world and leading countries. This research will be an important source of information that will help to address performance questions in the context of STEM activities in Malaysia. Possible High Impact Journals for Publications Scientometrics; Journal of Informetrics Journal of the American Society of Information Science & Technology (JASIST) Collaborators Malaysian Citation Centre, Ministry of Higher Education (Prof Dr Zainab Awang Ngah) Statistical Cybermetrics Research Group University of Wolverhampton (Prof Dr Mike Thelwall, Dr Jonathan Levitt, Ms. Fereshteh Didegah) Kharazmi University, Iran (Dr Hamid R.Jamali) Faculty of Computer Science & Information Technology, University of Malaya (Dr Ram Gopal Raj, Dr Kiran Kaur; Dr Muhammadamin Erfanmanesh) High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/FCSIT/12 Title: Implementation of Secure Framework for Electronic Medical Record (EMRs) Principal Investigator: Assoc. Prof. Dr. Miss Laiha Mat Kiah Department: Department of Computer System and Technology, Summary of Research Proposal The advancement of Information Technology has witnessed the automation and migration of many management systems. No exception is the management of Medical Records. For accessibility and availability reasons, these records are to be kept in digital format, i.e. referred to as Electronic Medical Records (EMRs). Since EMRs may be accessed and transmitted in different ways, it is very important to ensure that these records are kept and managed securely. In the development of telemedicine applications, protection of patients’ privacy and medical rec-ords is essential, and under no circumstances should this information be disclosed to a third party. One particular aspect in secure management of EMRs is secure transmission and ex-change of these records. If EMRs are transmitted, the transfer should be conducted in a strict and secure manner. This research seeks to develop secure techniques and solutions to address this issue. Objectives Methodology EMR security is one of the most challenging tasks in this mission. EMRs are transferred and stored in different platforms and networks. In this research, we aim to develop secure solutions for EMRs over different platforms and networks. We will conduct the research in three phases. Phase 1 Analyzing the existing EMR security transmission system includes the identification of security parameters for secure management of EMRs. Phase 2 - Prototype Development will involve the implementation of proposed secure framework. Phase 3 - Testing and Evaluation will involve the implementation of proposed solu-tion on different platforms and networks. Outcome 1. Better understanding and awareness on securing EMRs. 2. Secure implementation and management of EMRs. Possible High Impact Journals for Publications 1. International Journal of Medical Informatics 2. Journal Medical Care. 3. Journal of the American Medical Informatics Association. 4. Journal of Health Services Research. Collaborators Po Lung Yu, Institute of Information Management, College of Management, National Chiao Tung University, Hsin Chu, 30010, Taiwan; and School of Business, University of Kansas. Keith M. Martin, Information Security Group, Royal Holloway, University of London. 145 146 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/FCSIT/13 Title: An Approach using New Information Extraction based Traceability and Adaptive Clustering Techniques to Trace and Cluster Requirements for Software Maintenance and Quality Assessment. Principal Investigator: Professor Dr. Lee Sai Peck. Faculty: Faculty of Computer Science and Information Technology Summary of Research Proposal This research aims to develop an approach using new IE-based traceability and software clus-tering techniques for requirements traceability and clustering. The IE-based traceability tech-nique will extract and trace requirements including non-functional requirements from and in software artifacts of projects automatically, whereas the clustering technique that is capable of scaling dynamically with the project size will produce a high-level abstraction of software de-sign from these artifacts. An automated solution based on the approach will be produced. Objectives Methodology Outcome 1. To determine a suitable approach using IE-based traceability and software clustering techniques for requirements traceability and clustering. 2. To propose a new IE-based traceability technique to extract and trace nonfunctional re-quirements from/in the software artifacts of projects automatically. The research begins with an in-depth study of literature on requirements traceability and cluster-ing. Due to the textual nature of majority of the information sources in the field of requirements traceability, we decide to use IE techniques, i.e. a branch of Text Mining (TM) method that ex-tracts information from textual format of documents to trace requirements. A study on the fun-damental concepts of software remodularization in reverse engineering will also be conducted. In searching for the optimum solution, a new adaptive software clustering technique will be in-troduced in this research. The idea of adaptive clustering technique is meant to cater for large software projects while minimizing the time to execute the proposed solution. An approach supported by a new IE-based traceability technique to trace requirements and a new adaptive clustering technique to cluster requirements for software maintenance and quality assessment. 3. To propose a new adaptive clustering technique that is capable of producing a high-level abstraction of software design and scales dynamically with the project size. 4. To produce an automated solution based on the approach that uses the proposed tech-niques. 5. To assess, evaluate and benchmark the proposed solutions. Possible High Impact Journals for Publications 1. IEEE Software 2. Information and Software Technology 3. ACM Transactions on Software Engineering and Methodology 4. Computer 5. IEEE Transactions on Software Engineering Collaborators Professor Colette Rolland, Université Paris 1 PanthéonSorbonne High Impact Research Annual Report 2012 RESEARCH PROPOSAL (HIR-MoHE 4 Years) Chancellory Project No: UM.C/625/1/HIR/MOHE/CHAN/11 Title: Molecular Phylogenetics and Systematics Principal Investigator: Prof Dr Yong Hoi Sen Department: Faculty of Science Summary of Research Proposal The study will focus on organisms of agriculture and public health importance and species with unique/specific features (e.g. parasites, generalists and specialists). It aims to provide answers to the systematic status of species complexes (occurrence of cryptic/sibling species), phylogenetic relationships, phylogeography, phylogenomics, and genetic markers for diseases. The main approach will be DNA sequencing and genome analysis. Objectives Methodology 1. DNA sequences of selected genes will be analyzed to determine phylogenetic relationships, genetic diversity and systematics (occurrence of cryptic/sibling species, taxonomic identification, etc). For certain groups, organisms from various geographical areas (e.g. Wallacea, Indochina) will be used also for biogeography/phylogeography analysis. A draft Genome will be generated for flagship organism using sequence-by-synthesis approach (PacBio and Illumina sequencers). 2. 3. Phylogenetics, phylogeography and systematics of parasites of public health im-portance – e.g. Angiostrongylus spp. and Anisakis spp. Focus will be on molecular dif-ferentiation using DNA sequences and immunodiagnosis. The genome of Angiostrongy-lus spp will be attempted. Phylogenetics, systematics, phylogeography and biodiversity of arthropods – or-ganisms include tephritid fruit flies (of agiculture importance), odonates (beneficial in-sects), stingless bees (beneficial insects), spiders (beneficial animals) and other groups with unique life history. Phylogenomics of selected animals with unique features will be studied. Phylogenetics, phylogeography and systematics of vertebrates – focus will be on amphibians, reptiles and mammals. 4. Genotyping of diseases – e.g. Parkinson’s Disease, angiostrongyliasis and anisakiasis. 5. Phylogenomics – flagship organisms with unique features. Possible High Impact Journals for Publications A. No. Of Tier 1 Publications Expected 11 in 4 years B. List of 5 Tier 1 ISI/Web of Science Journals (PloS ONE, Emerging Infectious Disease, Parkinsonism and Related Disorder, Molecular Biology and Evolution, BMC Genomics ). Collaborators Dr. Lim Phaik Eem (Institute of Biological Sciences, UM) Outcome Dr Praphathip Eamsobhana (Faculty of Medicine Siriraj Hospital, Mahidol University, 4 publications have been published and 2 publications have been accepted: Thailand) Emerging Infectious Disease (ISI – Q1), Parkinsonism and Related Disorders (ISI – Q1), Journal of Science and Technology in the Tropics (Scopus), The Raffles Bulletin of Zoology (ISI – Q2), Biodiversity Pulau Tioman (book). Professor Masafumi Matsui (Kyoto University, Japan) Professor Masayuki Sumida (Hiroshima University, Japan) Dr I. Wayan Suana (Mataram University, Indonesia) Dr Loh Han Chern (UTAR, Malaysia) Professor Lim Shen Yang (Faculty of Medicine, UM) 147 148 High Impact Research Annual Report 2012 Project No: UM.C/625/1/HIR/MOHE/CHAN/12 Title: Neurosurgery Movement Disorder And Operative Device Development Research Principal Investigator: Prof Dr Vickneswaran Mathaneswaran Department: Faculty of Medicine Summary of Research Proposal A. Transfer primate work conducted in Oxford to UM-Human and rat olfactory stem cells injected into the striatum reverses Parkinsonian symptoms in a rat model to be repeated in MPTP treated monkeys. Functionality of autologous transplantation of olfactory stem cells overcomes ethical problems of foetal transplants and revolutionizes treatment of PD and other causes of akinesia. B. To develop and expand work on neurosurgical endoscopic devices and surgical simulation-The team in UM develops novel devices and training modules utilizing 3D pro-totyping techniques. Success leads to accurate simulative surgery utilizing models using actual patient data creating specific models with pathologies for training and testing newly developed devices. Objectives Methodology Collaborators Project A-Overall aim to is improve surgical treatment of akinesia A. Assoc. Prof. Dr. Dharmendra Ganesan Project B-Develop a variety of anatomically accurate models with pathology, assess and verify accuracy of models developed, allow testing of a variety of materials with models having tissue characteristics, integrate electronic systems allowing automated detection and track training procedures, develop surgical devices for neurosurgical neuroendoscopy. B. Primate Research In Neurosurgery- Identify the association of anatomical, physiological and radiological correlations using primate models and initiation of stem cell research in basic sciences and clinical applications. Surgical Biomodel Simulators And Tool DevelopmentCreate similar models with pa-thology and assess accuracy and usefulness as simulation devices. Associate Professor Kamal Azrin Abdullah @ Kalai Arasu A/L Muthusamy Dr. Hari Chandran Thambinayagam Dr. Sia Sheau Fung Dr. N.Vairavan A/L N.V.V.E Narayanan Prof Dr Zainal Ariff B Abd Rahman Outcome Professor John F Stein 3 publications have been accepted: Dr. Nick de Pennington Journal of Clinical Neuroscience (ISI- TIER 4),Journal of Neurological Surgery -Part A (ISI- TI-ER 4), American Journal of Rhinology & Allergy (ISI- TIER 1). Possible High Impact Journals for Publications A. No. Of Tier 1 Publications Expected 10 in the initial 2 years (both projects) B. List of 5 Tier 1 ISI/Web of Science Journals (both projects-Nature Neuroscience, Lancet, Cell Research, Movement disorder,and Journal of Neurosurgery). UM HIR PUBLICATION HIGHLIGHTS 2012 150 High Impact Research Annual Report 2012 UM HIR PUBLICATION HIGHLIGHTS 2012 Prof. Rauzah Hashim from the Department of Chemistry has come a long way since she developed an interest in computational science research. “Strange as it may seem, prior to 1990, computational science as a subject was quite unheard of in Malaysia, let alone using it to solve problems”, said Rauzah. However, this did not deter her from taking on this research challenge after graduating from the University of Southampton in liquid crystal modelling, making her a pioneer in the field of computational science in Malaysia. PROF. DR. RAUZAH HASHIM One of the major challenges she faced in the early days was a lack of general facilities in computing. She set herself the task of rectifying this and went on to set up the Internet facilities in her department in 1992, allowing her to be connected to any fast computers in the world and to her fellow theoretician friends and liquid crystallers worldwide. “The kimia network with over 70 nodes, which I established was four years ahead of the University campus wide network”, she proudly claimed. From 1990 and for the next 10 years, Rauzah conducted many seminars and workshops to popularize the subject of computational science in Malaysia. Subsequently many high performance computational centers reflecting much of her early ideas were established, including the one in MIMOS set up in 2003. She was a member of the University of Malaya Campus Network Technical Committee (1996-1998), the MIMOS National GRID Initiative (2006-2009) as well as a member of the ICS-UNIDO Expert Group for the Combinatorial Chemistry and Related Sciences (1997-2003). She won numerous grants locally and abroad. Her expertise in informatics sciences (modeling, simulation and database) proved useful when in 2002, she was entrusted to lead one of the MOSTI top-down strategic programs entitled “Glycolipid Science and Technology”, leading 4 institutions to research into glycolipids from synthesis, fundamental studies as well as development of applications for surfactants and nano-materials. This project developed and synthesized the branched-chain glycoside family which won many awards and recognition for its potential use in liquid crystal applications. The accolades include the Gold Medal and Special Award from Taiwan at the ITEX Geneva 2005 and the 2007 finalist in The Prime Minister Innovation Awards. To this day, Rauzah continues to pursue fundamental investigations from molecular and phenomenological approaches, relating structures to properties with the aim to understand natural processes and improving new materials and formulations. Rauzah is the principal investigator of the high impact research grant (HIR-UM/MOHE) on the Fundamental Science of Self-Assembly (2011-2016). The focus of this research is on understanding the fundamental aspects (static, dynamics, theory and simulation) of selfassembly materials including liquid crystals and nanomaterials. She has established an extensive network of collaborators from renowned institutions worldwide (University of Southampton, Imperial College, University of Manchester, Hamburg University, University of Pavia, Kent-State Liquid Crystal Institute, CSIC Barcelona, Sultan Qaboos University, Muscat and King Abdul Aziz University, Jedah). With the motto of “the future is now!”, Rauzah and her collaborators have contributed actively to high impact publications through the HIR MoHE funding. High Impact Research Annual Report 2012 151 152 High Impact Research Annual Report 2012 TIER 1 PUBLICATIONS No Year 1 2012 Molecular Dynamics Study of Anhydrous Bi-layers of Synthetic Glycolipids: Effects of Chain Branching and Disaccharide Headgroup Title Journal of Physical Chem-istry B (DOI:10.1021/jp302292s) Journal Impact Factor 3.696 2 2012 Fluorescene Probing of the Temperature –Induced Phase Transition in a Glycolipid Self-Assembly Langmuir 28(11): 4989-4995 4.26 3 2012 Physicochemical Characterization of Natural-like Branched-Chain Glycosides towards for-mation of hexosomes and vesicles Langmuir, 2012, 28 (5), 2395 2403 4.9 4 2012 Preparation and Characterization of Ti oxide, SnO2 nanoparticles decorated grapheme Ceramics International, 38: 42094216, (Q1) 1.68 5 2012 Green synthesis of colloidal silver nanoparti-cles by sonochemical method Materials Letters 66: 117-120 2.19 6 2012 Highly Efficient preparation of ZnO nanorods decorated Reduced Graphene Oxide Nano-particles Materials Letters. Accept-ed. (Q1) 2.194 7 2012 Facile preparation of graphene-based Chitosan Films : Enhanced thermal, mechanical and antibacterial properties Journal of Non-Crystalline Solids, 358(3): 525-530 1.537 8 2012 Graphene Oxide and Its Electrochemical Per-formance Int. Journal of Electro-chemical Sci, 7 (2012) 4345-4351 2.808 9 2012 Effects of carbon substrates on biodegradable polymer composition and stability produced by Delftia tsuruhatensis Bet002 isolated from palm oil mill effluent. Polymer Degradation and Stability (DOI 10.1016/j. polymdegradstab.2012.05.041) 2.594 10 2012 Biosynthesis and Characterization of Polyhydroxyalkanoates Copolymers Produced by Pseudomonas putida Bet001 Isolated from Palm Oil Mill Effluent PLOS ONE (accepted) 4.092 11 2012 Alkyl triazole glycosides (ATGs)-A new class of bio-related surfactants Colloids Surf B Biointerfaces. 2012 Sep 1;97:196-200. Epub 2012 Apr 28. 2.780 12 2011 Ultrasound Assisted Lipase Catalyzed of poly-6-Hydroxyhexanoate Ultrasonics Sonochemistry 19: 659667 3.4 13 2011 Characterization of the Head Group and the Hydrophobic Regions of a Glycolipid Lyotropic Phase using Fluorescent Probes Journal of Phys. Chem. C (2011), 115 (40), 19805-19810 4.52 14 2011 Fabrication and Characterization of Graphene Hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth Int. Journal of Nanomedicine 6: 18171823 4.9 15 2011 Simple Room Temperature Preparation of High-Yield large –Area Graphene Oxide Int. Journal of Nanomedicine 6: 34433448 4.9 16 2011 Spherical Tin Oxide, SnO2 Particles Fabricat-ed via Facile Hydrothermal Method for Detec-tion of Mercury (II) Ions Int. Journal of Electro-chemical Sci, 6 (2011) 4329-4340 2.8 17 2011 Morphological studies of randomized disper-sion magnetite nanoclusters coated with silica Ceramic International 37 : 451-464 1.68 UM HIR SPECIAL FEATURE 2012 154 High Impact Research Annual Report 2012 UM HIR SPECIAL FEATURE 2012 DR. HUANG NAY MING UM HIR was proud to announce the news that Dr. Huang Nay Ming from Physics Depart-ment has been awarded the National Young Scientist 2012 by the Ministry of Science, Technology and Innovation for his outstanding research on graphene and nanomaterials. Earlier this year, Dr. Huang was also awarded the Young Researcher 2012 by Universiti Malaya. Syabas and well done. Huang Nay Ming was born in Marudi, Baram, Sarawak in 1978. Both his parents were farmers, working in the farm throughout the year. As the youngest in a family of eight siblings, he was fortunate to have the opportunity to further his studies up to the tertiary level. Huang graduated with BSc First Class Hons. in 2002 and was the recipient of the UKM Book Prize Award. He continued to pursue his MSc and PhD studies at Universiti Kebangsaan Malaysia. His postgraduate research focused on nanomaterials synthesis and applications. Upon completion of his PhD in 2009, Huang was employed by University of Malaya as Senior Lecturer in the Physics Department, Faculty of Science. He is a member of the Low Dimensional Materials Research Centre since then. His current research interest is slanted towards the fabrication of graphene and graphene-based nanocomposites. Huang applied these graphene nanomaterials in the fields of sensors, solar energy conversion and energy storage applications. Since 2009, his research has been funded by the Ministry of Higher Education, MOHE (ERGS, FRGS, HIR-MOHE), Ministry of Science, Technology and Innovation of Malaysia, MOSTI (e-Science fund, NND grant) and the internal grants of University of Malaya such as UMRG, HIR-UM and PPP grants. For HIR-MOHE grant, he is the co-researcher for two projects entitled “Fundamental of Self-Assembly” (RM 10.8 mil-lions) and “Synthesis and Applications of Low Dimensional Materials” (RM 8.8 millions). Recently, his proposal on “Graphene-Inorganic Nanocomposites and Their Applications” has been approved for the HIR-MOHE 3rd cycle application (RM 2.06 millions), which will enable him to work closely with the top graphene researcher from The University of Texas in Austin, Prof. Dr. Rodney Ruoff. In Malaysia, Huang pioneered research graphene which he started in 2009. He has published over 20 graphene papers in ISI-cited journals since then and is supervising 18 postgraduate students on graphene-related projects (6 PhD and 12 MSc students). Up till today, Huang has published 54 ISI-cited journal papers with a total citation of 352 and H-index of 11. In addition, he has filed 4 patents on graphene technology. He is also an active reviewer for more than 15 scientific journals and reviews more than 20 journal articles per year. “I am highly grateful for the opportunities given to me and the recognition by various parties and will work harder to achieve greater heights”, Huang said modestly. High Impact Research Annual Report 2012 PUBLICATIONS (ISI CITED JOURNALS) 2012 1. Vijay Kumar, S., Huang, N.M., N. Yusoff, Lim, H.N., 2012. High Performance Magnetically Separable Graphene/Zinc Oxide Nanocomposite. Materials Letters. Accepted. 2. Golsheikh, A.M., Huang, N.M., Lim, H.N., Chia, C.H., Harrison, I. and Muhamad, M.R. 2012. One-pot hydrothermal synthesis and characterization of FeS2 (pyrite)/graphene nanocomposite. Chemical Engineering Journal Accepted. 3. 4. 5. 6. 7. Vijay Kumar, S., Huang, N.M., Lim, H.N., Marlinda, A.R., Harrison, I. and Chia, C.H. 2012. One-step size-controlled synthesis of functional graphene oxide/silver nanocomposite at room temperature. Chemical Engineering Journal Accepted. Chook, S.W. C.H. Chia, S. Zakaria, M.K. Ayob, K.L. Chee, N.M. Huang, H.M. Neoh, H.N. Lim, R. Jamal, R.M.F.R.A. Rahman. 2012. Antibacterial Performance of Ag Nanoparticles and AgGO nanocomposites prepared via rapid microwaveassisted synthesis method. Nanoscale Research Letter. 7: 541. Fatin, S.O., Lim, H.N., Tan, W.T., Huang, N.M. 2012. Comparison of Photocatalytic Activity and Cyclic Voltammetry of Zinc Oxide and Titanium Dioxide Nanoparticles toward Degrada-tion of Methylene Blue. International Journal of Electrochemical Sciences. 7:9074-9084. Zainy, M., Huang, N.M., Vijay Kumar, S. and Lim, H.N. 2012. Simple and scalable prepara-tion of reduced graphene oxide-silver nanocomposites via rapid thermal treatment. Materials Letters 89: 180-183. P.S. Lim, H. N. Lim, N. M. Huang, C. H. Chia, I. Harrison. 2012. Room temperature in situ synthesis of Fe3O4/graphene nanocomposites. Ceramics International. 38: 6411-6416. 8. B.Y.S. Chang, N.M. Huang, M.N. An’ amt, M.A. Rahman, N. Yusoff, M.R. Muhamad, I. Harrison, C. H. Chia. 2012. Facile hydrothermal preparation of titanium dioxide decorated re-duced graphene oxide nanocomposite. International Journal of Nanomedicine. 2012(7):1-9. 9. M.A. Ehsan, N.M. Huang, M. Misran, Z. Arifin, E.R.T. Tiekink, A.P. Safwan, M. Ebadi, W. J. Basirun and M. Mazhar. 2012. Photoelectrochemical Characteristics of Greenockite Thin Films fabricated by AACVD using a Single-Source Cadmium Precursor, Chemical Vapor Deposition, 18:191-200. 10. H.N. Lim, R. Nurzulaikha, I. Harrison, S.S. Lim, W.T. Tan, M.C. Yeo, M.A. Yarmo, N.M. Huang, Preparation and characterization of tin oxide, SnO2 nanoparticles decorated graphene, Ceramics International 38: 4209-4216. 11. F. Y. Ban, H.N. Lim, S. R. Majid, N. M. Huang. 2012. Fabrication of graphene oxide for supercapacitor application. International Journal of Electrochemical Science 7:4345-4351. 12. M.A. Rahman, N. Yusoff, M.R. Muhamad, I. Harrison, M.N. An’ amt, B.Y.S. Chang, N. M. Huang. 2012. Highly efficient preparation of ZnO/reduced graphene oxide nanocomposites. Materials Letters 80:9-12. 13. Lim, H.N., Huang, N.M. and Loo, C.H. 2012. Facile preparation of graphene-based chitosan films: Enhanced thermal, mechanical and antibacterial properties. Journal of NonCrystalline Solids 358: 525-530. 14. M. Darroudi, A. K. Zak, M.R. Muhamad, N.M. Huang, M. Hakimi. 2012. Green synthesis of colloidal silver nanoparticles by sonochemical method. Materials Letters, 66: 117-120. 155 156 High Impact Research Annual Report 2012 PATENTS 1. A method for synthesizing tin-oxide-graphene nanocomposite for use as sensor materials, PI2012 700274, Filing date: 10 May 2012. 3. Large area graphene/graphene oxide as high performance nanofiller for polymeric films, PI2011700112, Filing date: 26 July 2011. The present invention relates to a method for synthesizing tin oxide-graphene nanocomposites and the tin oxide-graphene nanocomposites synthesized there-of for use as sensor materials. More particularly, the present invention provides an innovative method for synthesizing tin oxidegraphenenanocomposites via a facile and mild microwave hydrothermal process; and tin oxidegraphene nanocomposites synthesized thereof which are suitable to be used in various gas, chemical and bio-sensing applications. The present invention relates to preparation of natural, synthetic or conducting polymer composite films, more particularly topreparation of polymer films such as polyvi-nyl alcohol and chitosan films, with graphene oxide as filler. 4. Synthesis of magnetic nanophotocatalyst (ZnO/Fe3O4) for textile industry wastewater treatment, PI 20093869. Filing date: 16 September 2009. The invention describes preparation of ZnO/ Fe3O4 nanophotocatalyst with high perfomance in industrial wastewater treatment. 2. Method of making large-area graphene oxide, PI2011700072, Filing date: 12 May 2011. The present invention relates generally to preparation of graphene oxide, more particularly to preparation of graphene oxide via oxidation of graphite. High Impact Research Annual Report 2012 UM HIR SPECIAL FEATURE (2 FEBRUARY 2012) PROF. DR. HARITH AHMAD HARITH AHMAD hails from the Department of Physics and heads the Photonics Research Centre in UM (PRCUM). This Centre, established in 2007, has recently been identified as a potential High Centre of Excellence (Hi-CoE) by the Ministry of Higher Education in recognition of the contribution of Harith and his dedicated team of researchers in photonics research in the country. PRCUM has been actively engaged in research of optical passive and active waveguides, namely Erbium-doped optical amplifier and laser, nonlinear wavelength conversion, fibre Bragg gratings (FBG), and fabrication of planar lightwave circuits. Facilities in PRCUM include optical fibre test and measurement systems, optical planar waveguide fabrication, FBG fabrication, micro-fibre workstation, femtosecond laser oscillators as well as laser direct writing system for polymer waveguide fabrication. According to Harith, the introduction of high impact research (HIR) in UM has opened up oppor-tunities for PRCUM to venture into niche photonics research areas such as photonics THz gen-eration as well as micro- and nano-fabrication of plasmonics and photonics metamaterials. This allows PRCUM to develop better human resources and to contribute to further advancement and research in the field of photonics in Malaysia. Harith has received many prestigious national and international awards, including the 2010 Merdeka Award for his pioneering work on solid state lasers in the country. He and his team have published over 300 research papers in international journals, the most recent are those listed below. Recent Publications H. Ahmad, N.A. Awang, A.A. Latif, M.Z. Zulkifli, Z.A. Ghani and S.W. Harun Wavelength conversion based on four-wave mixing in a highly nonlinear fiber in ring configura-tion. Laser Physics Letters 8, No. 10, 742-746 (2011) S.W. Harun, R. Akbari, H. Arof and H. Ahmad Mode-locked bismuth-based erbium-doped fiber laser with stable and clean femtosecond pulses output. Laser Physics Letters 8, No. 6, 449-452 (2011) Chang Hong Pua, Siti Fatimah Norizan, Sulaiman Wadi Harun and Harith Ahmad Non-membrane optical microphone based on longitudinal modes competition. Sensors and Actuators A, 168, 281-285 (2011) 157 158 High Impact Research Annual Report 2012 UM HIR SPECIAL FEATURE EMERITUS PROFESSOR DR. YONG HOI SEN Publication of the book on Biodiversity Pulau Tioman The publication of this book Biodiversity Pulau Tioman by Academician Emeritus Professor Dr. Yong Hoi Sen and his team marks a significant milestone in UM HIR which supported his field trips under a special allocation from Chancellory to undertake field trips to many exciting areas in Malaysia, including Pulau Tioman. Many specimens that he had collected are probably new to science and will form part of his pursuit on molecular phylogenetics and systematics. Prof. Yong is from the Institute of Biological Sciences, Faculty of Science, UM, and is a Senior Fellow of the Academy of Sciences Malaysia and a recipient of the Merdeka Award 2010 for Outstanding Scholastic Achievement. He is also a member of the UM HIR Committee and a recipient of a grant under Cycle 3 MoHE to conduct research on Molecular Phylogenetics and Systematics. Prof. Yong has authored over 300 articles and several books on the natural heritage of Malaysia. He has served as editor for several journals, scientific monographs, magazines and the Animals volume of the Encyclopedia of Malaysia. About the book This book provides pictorial glimpses of the biological diversity of Pulau Tioman, off the coast of Pahang Darul Makmur, Peninsular Malaysia. It covers ecosystem, plant diversity, animal diver-sity, and conservation. Different life forms and habits as well as the landscapes are presented to provide an overview of the great diversity of the island. It should be an interesting read to a variety of people from different walks of life and from different lands. The colour illustrations will help readers to appreciate the fascinating biodiversity of the island. Dato’ Sri Douglas Uggah Embas, Minister of Natural Resources and Environment Malaysia, in his foreword to this book, congratulated the Department of Wildlife and National Parks as well as Professor Emeritus Dr. Yong Hoi Sen and the team for initiating this educational and resourceful publication. He said that the publication of this pictorial book is in line with the global biodiversity targets to enhance awareness on biodiversity at all levels of society by 2020 and is an important ingredient to pave the way for mainstreaming of biodiversity in all sectors as envisaged in the National Policy on Biological Diversity (1998) and also the Common Vision on Biodiversity.(2009). HIR congratulates Prof. Yong Hoi Sen for achieving yet another milestone in his rich academic career. HIR ACTIVITY HIGHLIGHTS 160 High Impact Research Annual Report 2012 HIR ACTIVITY HIGHLIGHTS Visit Of UM Nobel Fellow, Prof. Barry Marshall On 13th January 2012, UM Nobel Fellow, Prof. Barry Marshall, paid a courtesy call to Prof. Adeeba Kamarulzaman, Dean of Medicine, and took the opportunity to review the progress of the MoHE-funded Helicobacter pylori projects jointly conducted between the University of Western Australia and UM. Barry is also here to attend the Asian Pa-cific Helicobacter pylori meeting 2012 at the Hotel Shangri-La. Barry in deep discussion with UM Research Assistants and reviewing the progress of the UM HIR-MoHE Barry leading the discussion in search of new top-down proposals for the MoHE Cycle 3 fund. Present were collaborators from France, Japan, Thailand, & USA. High Impact Research Annual Report 2012 UM HIR NEWS (6TH APRIL 2012) Update on Cycle 3 MoHE HIR Applications At the close of Cycle 3 MoHE submission dateline, 116 applications were received by Central HIR (see accompanying figure). Engineering, Medicine and Science together accounted for 78.4% of the total applications. Of interest were the 11 proposals from the Social Science disci-plines. The budget request for 116 projects was RM219,387,273, leaving a shortfall of RM54,363,544 since the balance we have was only RM165,023,729. The various HIR commit-tees were requested to scrutinize proposals in their respective disciplines to ensure that only the most deserving proposals of high quality will be selected for funding. All proposals will be exter-nally reviewed before submission to the Ministry of Higher Education in May. It is gratifying to note that the PIs are targeting high impact journals for publication, including in Nature (9), Science (4), PNAS (3), PLoS (12), NEJM (1), Lancet (1) and BMJ (1). Hopefully these targets will be achieved by the end of 2015. No PTj Budget (RM) No of Project 1 Engineering 47,809,479.00 32 2 Medicine 31,159,988.00 30 3 Science 50,080,617.00 29 4 Dentistry 5 Chancellory 6 FCSIT 7 Social Science 8 Built Environment Total 9,550,540.00 6 63,049,134.00 3 +1 1,624,500.00 4 15,913,015.00 11 200,000.00 1 219,387,273.00 (-RM54,363,544.00) Balance available for 2013-2015 – RM165,023,729 116 161 162 High Impact Research Annual Report 2012 UM HIR NEWS (20TH APRIL 2012) Prof. Wong Chi Huey is President of Academia Sinica, Taipei, and was here from 9-10 April on the invitation of HIR to sign a MoU with UM. He is currently an Editorial Advisory Board member for the Journal of American Chemical Society, Angewandte Chemie, Advanced Synthesis and Catalysis, and Current Opinion in Chemical Biol-ogy. He is also a member of Board of Scientific Governors of the Scripps Research Institute, the Steering Committee of the Lilly TB Drug Discov-ery Initiative, and the Chief Science Advisor of the Ministry of Science, Taiwan. His research interests are in the areas of bioorganic and synthetic chemistry and biocatalysis, including syn-thesis of complex carbohydrates, glycoproteins and small-molecule probes for the study of car-bohydrate-mediated biological recognition, post-translational glycosylation, and drug discovery. He is the author and co-author of over 700 publi-cations, 100 patents, and four books (Enzymes in Synthetic Organic Chemistry, Combinatorial Chemistry in Biology, Catalysis from A to Z, and Carbohydrate-Based Drug Discovery). President Wong giving a talk on “From Discovery Research to Translational Innovation” in the Faculty of Science. This was followed by visits to several faculties for dialogue sessions on research collaboration. Abstract: “From Discovery Research to Translational Innovation” The talk presented recent advances in carbohydrate chemistry and biology with emphasis on a scientific research path from discovery research to innovative development to illustrate the im-portant contribution of this field. Protein glycosylation is the most complex post-translational process; more than 90 percent of human proteins are predicted to be glycosylated. The significance of glycosylation at the molec-ular level is however not well understood, and as such the pace for the development of carbo-hydrate-based drug discovery and diagnosis is relatively slow. It is thus important to develop new tools to study the effect of glycosylation on the structure and function of proteins and other biologically active molecules. This presentation will focus on the development of new methods for the synthesis of homogeneous glycoproteins with well defined glycan structure, study of gly-cosylation effect on protein folding, development of glycan arrays for disease diagnosis and for the high-throughput analysis of protein-glycan interaction, and design of carbohydrate-based therapeutics and vaccines to tackle the problems of cancer and infectious diseases. High Impact Research Annual Report 2012 UM HIR NEWS (24TH APRIL 2012) UM Breast Cancer Research Team Calls for Standardization of Clinical Breast-Density Measurement Professor Kwan-Hoong Ng, a senior medical physics professor at the Department of Biomedical Imaging, University of Malaya, and Prof. Yip Cheng Har and Associate Professor Nur Aishah Mohd Taib, from the Department of Surgery, University of Malaya, have published a timely article in the Lancet Oncology that will have impact on women’s health globally. They argue for the standardisation of clinical breast density measurement based on three dimensional data. This issue has also caught the attention of the international community. For a long time Prof. Ng has been leading multi-disciplinary research on the early detection of breast cancer using imaging techniques, and in particular improving method to measure accurately the amount of glandular tissue in the breast, known as breast density. Women with dense tissue in 75% or more of the breast face a risk of breast cancer that is four to six times greater than women with little or no dense tissue. In another word, high breast density generally has a relatively higher breast cancer risk. The Mammography Reporting Act of 2011 was introduced to US Congress during the Breast Cancer Awareness month. This Bill requires physicians to provide information regarding a pa-tient’s breast density in every mammography summary following mammographic examination. Additionally, they are required to provide counsel on the increased risk faced by those found to have dense breast. The other countries are expected to follow this development with great in-terest. Traditionally, the assessment of mammographic breast density is subjective and depends on the training and experience of the radiologist. Professor Ng echoed that “there is an urgent need to establish and validate an international standard for clinical breast density measurement that considers the breast volumetrically. Guidelines for standardised measurement techniques and a quality control protocol should be set up.” In his research, Professor Ng has been working with breast surgeons and radiologists, together with several of his international medical physics collaborators. Professor Ng has also called for greater awareness of breast density among the medical profession and the public that will play an essential role in breast cancer risk management and thus saving thousands of lives. The article entitled “Standardisation of clinical breast-density measurement” can be found in the Lancet Oncology 13, 334-336 (April 2012). 163 164 High Impact Research Annual Report 2012 UM HIR NEWS (25TH APRIL 2012) JOINT PRESS RELEASE BY UNIVERSITI MALAYA AND CANCER RESEARCH INITIA-TIVES FOUNDATION Malaysian scientists contribute to a study published in NATURE-Medicine discovering a new function for breast cancer gene BRCA1 Scientists at the National Cancer Institute (NCI) have uncovered a new function for BRCA1, a gene most commonly associated with hereditary breast and ovarian cancer. Working on mouse cells in the lab, they discovered that BRCA1 suppresses the expression of another gene that codes for a microRNA called miR-155, which is known to be cancer causing. These findings, published online Sept. 25, 2011, in Nature Medicine suggest that BRCA1 functions as a tumor suppressor not only by playing a role in DNA repair, as known previously, but also by silencing a gene that can cause cancer when over-expressed. When the scientists inactivated miR-155 in tumor cells in mice, it slowed down the growth of tumors. If the BRCA1-associated tumors are confirmed to be dependent upon miR-155, it may be possible to treat hereditary cancers by challenging them with agents that can inactivate mir-155. The scientists also investigated precisely how BRCA1 silences miR-155 in cells. Shyam K. Sharan, Ph.D, head of the Genetics Cancer Susceptibility Section, Mouse Cancer Genetics Program, NCI-Frederick and Suhwan Chang, Ph.D., research fellow, found that BRCA1, through its interaction with another protein called histone deacetylase2, modifies the proteins (known as histones) that wrap around DNA and help maintain its structure. As a result of these modifications, DNA is prevented from expressing miR-155. If there is a defect in BRCA1, these modifications of DNA do not occur and miR-155 is over-expressed. Based on a strong correla-tion between BRCA1 mutation and miR155 over-expression in tumors, the scientists also sug-gest that miR-155 could be used as a biomarker for BRCA1deficient human tumors. (From the National Cancer Institute News Note) “We are delighted to have had the opportunity to contribute to Dr Sharan’s study. Since 2003, CARIF and University Malaya have established the Malaysian breast cancer genetic study and through this study, we have identified genes which cause some individuals to be more likely to develop breast cancer. The collaboration with Dr Sharan has enabled us to understand the function of these genes even better,” says Prof Teo Soo Hwang. The full article entitled “Tumor Suppressor BRCA1 epigenetically controls oncogenic miRNA-155” can be found in Nature Medicine (2011) Sep 25;17(10):1275-82. doi: 10.1038/nm.2459. Erratum in: Nat Med. 2011 Nov; 17(11):1521. Nat Med. 2011 Oct; 17(10):2 p following 1282 The complete list of authors is as follows : Suhwan Chang, Rui-Hong Wang, Keiko Akagi, Kyung-Ae Kim, Betty K. Martin, Luca Cavallone, kConFab, Diana C. Haines, Mark Basik, Phuong Mai, Elizabeth Poggi, Claudine Isaacs, Lai M. Looi, Kein S. Mun, Mark H. Greene, Stephen W. Byers, Soo H. Teo, Chu-Xia Deng and Shyam K. Sharan. Soo H. Teo is Chief Executive, Cancer Research Initiatives Foundation and Adjunct Professor, University Malaya Medical Centre, Kuala Lumpur, Malaysia. Lai M. Looi (left) and Kein S. Mun (right) are from the Department of Pathology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia. High Impact Research Annual Report 2012 UM HIR NEWS (25 SEPTEMBER 2012) UM HIR First Year Anniversary of MoHE Funding UM Vice-Chancellor, Tan Sri Dr. Ghauth Jasmon, kindly officiated the function to mark the first year anniversary of MoHE Funding for high impact research in UM. The event was attended by HIR principal investigators and their research teams, including postdocs and postgraduate students. Tan Sri VC reminded the audience as to why UM is the only research university in the country which received this special allocation of RM590 million. He firmly believes that world university ranking is important in enhancing the global image of the institution and has pledged to the Cab-inet that UM will try to get within the top 100 QS World University Rankings by 2015. “In the last 2 years, UM has performed well by jumping 51 positions. Now we need to beat another 56 uni-versities to reach the 100th position by 2015. If we can achieve that, then I am confident of getting better research funding for UM HIR to enable us to reach the top 50 QS World University Rankings by 2020” he said. Tan Sri VC congratulated the HIR Committee for its many achievements in the last 12 months, including the setting up of the UM HIR Advisory Council, consisting of 3 Nobel Laureates and 2 Distinguished Professors. The 5 Council members are actively engaged in research with UM PIs and have provided invaluable guidance and support through their respective ivy-league institutions. Tan Sri VC commended the PIs for making remarkable progress in the quality and quantity of their publications, including several articles in high impact Tier 1 ISI/WoS journals such as Nature and Lancet. “I have been informed by Prof. Dato’ Dr. Amin Jalaludin, Chairman of the Pre-HIR Committee, that another 3 papers are under review in Nature Genetics, with many more in the pipeline in the coming years.” said Tan Sri. Tan Sri VC went on to inform the audience that the granting of university autonomy recently by the government comes with it a lot of added responsibilities for him and the University Board. “The government has set KPIs for all autonomous universities in terms of operating cost. UM will have to raise 20% of its operating cost in 2012, 30% in 2015 and 50% in 2020. All senior academic staff, especially professors, have to find innovative ways to raise funds to help the university. Don’t leave it all to me or to the Board members,” quipped Tan Sri. He warned that the coming few years will be extremely challenging for UM. “Not only do we have to get into the top 100 world ranked universities by 2015, we also now have to find the additonal operating funds to keep pace with the fast development of UM. The future of UM is not only based on ac-ademic progress but also on business acument of the VC. Nevertheless, I have faith in the loy-alty and support of UM warga, and together, we can bring UM to greater heights and regain our past glory!” Tan Sri concluded. 165 166 High Impact Research Annual Report 2012 High Impact Research Annual Report 2012 UM HIR NEWS (7 SEPTEMBER 2012) The UM HIR Committee is pleased to announce the appointment of Prof. Rofina Yasmin Othman to be a member of the Central HIR Committee by Tan Sri VC. Yasmin is attached to the Institute of Biological Sciences, Faculty of Science and Centre for Research in Biotechnology for Agriculture CEBAR , UMBIO, University of Malaya. Yasmin completed her MSc at the University of Malaya in 1990. She was awarded a Chevening scholarship to pursue a Ph.D. in Plant Virology at the John Innes Institute of Plant Science, U.K. On her return, she joined UM as a lecturer in the Department of Genetics and Cellular Biology and was appointed as a full Professor in 2005. She runs an active research group and has published extensively, focusing on utilising modern biotechnology strategies to tackle fundamental problems in agriculture and has filed 10 patents and graduated more than 12 PhD and 25 MSc students from her laboratory. She is a member of the International Banana Genomics consortium, an associate Fellow of the IMBN, an associate fellow of the Academy of Sciences Malaysia, was a member of UNIDOs South-South Biosafety network and is a founding member of the Asian Network for Biosafety Education. She was a member of the National Genetic Modification Advisory Committee Malaysia and is currently a member of the National Biosafety Board. Yasmin was the founding head of the Centre for Research in Biotechnology for Agriculture (www.cebar.um.edu.my) and Chair of the University’s Biotechnology and Bioproduct Cluster (UMBIO) where she initiated strategies for moving University R&D into the innovation value chain. She is also chief editor of the Asia Pacific Journal for Molecular Biology and Biotechnology and is on the editorial board of several other scientific journals. She recently completed a 3 year secondment to the Ministry of Science Technology and Innovation Malaysia as Undersecretary of the National Biotechnology Division, (www.biotek.gov.my) which is tasked with the implementation of national policies and strategies in Biotechnology as well as overseeing six National Institutes and government linked agencies. She is also a founding trustee of the National Institutes of Biotechnology Malaysia. During her tenure with MOSTI, Malaysia launched the Bioeconomy Initiative Malaysia designed to spur growth of the biotechnology industry. Recently she also spearheaded the committee which led to the formation of the National Bioethics Council. She has sat on the Board of Directors of the Malaysian Agriculture Research and Development Institute MARDI (alternate), the Board of Governors of the International Centre for Genetic Engineering and Biotechnology, Trieste Italy, was Malaysia’s representative to the Asean Subcommittee on Biotechnology and is the National Point of Contact (NPC) for UNESCO’s Microbial Biotechnology Network and SEA-EU-NET FP7(Biotechnology). Her own research interests are in the application of Biotechnology to value add to agriculture especially in the utilisation of biotechnology for sustainable use; improvement and conservation of local plant genetic resources as well as in areas relating to BioPolicies, Bioethics and Biosafety. Her international affiliations currently include programmes with Fraunhofer IME in Germany, QB3 at UCSF in the USA and The John Innes Institute in the UK. 167 168 High Impact Research Annual Report 2012 UM HIR NEWS (1 OCTOBER 2012) QMEC Audit of HIR UM Quality Management and Enhancement Centre (QMEC) conducted an internal audit from 7-25 May 2012 to check on the management of HIR projects to ensure conformity to requirements of UM and MoHE. The audit focussed on the plannning, implementation, monitoring and actions for improvement on every stage of research management. Research projects funded internally by UM and externally by MoHE were randomly sampled from all five faculities and from projects under Chancellory. The QMEC audit findings were submitted in a report to Tan Sri VC and the Central HIR Committee following an audit process which involved careful documentation review, dialogue sessions with the VC, HIR Secreteriat staff and researchers as well as site visits. In all, the audit team raises 2 commendations (best practices worthy of praise), 5 affirmations (good practices that should be maintained/enhanced), and 8 areas for improvement (areas where there are concerns and need improvement). Commendations 1. The audit panel commends UM’s management as well as the researchers for rising to the challenge in making this project a success and giving a new momentum to UM’s research endeavors. 2. The panel also commends the principal investigators and the research teams for their passion, commitment and perseverance in carrying out their research activities in a timely manner as stipulated in their proposal. Affirmations 1. The panel affirms the various improvement efforts by the HIR secretariat in the management and selection process, including the setting up of PTjs’ HIR secretariat. 2. The panel applauds the HIR Secretariat for formulating the requirement and devising a travel report. However, there should be standardization of travel arrangements and enhanced monitoring 3. Commended the PTjs and HIR Secretariat for the assurance of space for research. A space audit should be conducted for a fairer distribution and space provided for equipment purchased. 4. All information disseminated through e-mails must be concurrently up-dated on the web-page. All communications done via e-mails must be kept as records. Recommendations 1. HIR should set specific criteria for assessors and formulate a guideline for appointment 2. Records of application, approval and award of projects should be cleaned-up and up-dated. All documentation should be verified and signed by concerned parties. 3. To re-look into the procedures/guidelines of appointing RAs and other support staff/assistants, spelling out clearly their Terms of reference. 4. PIs should up-date their research group members/collaborators and inactive members be removed. 5. A system similar to e-finance be set up for finance monitoring 6. There should be a realignment of management so as to create a link between Central HIR Secretariat and PTj Secretariats. 7. To review the Progress Review Form and improve it to ensure holistic monitoring of KPIs 8. To establish a database/system for monitoring of KPI achievement and an early warning system for non-performers Conclusion Although this internal audit by QMEC was carried out on a sampling process, it was still useful to HIR to receive its various recommendations. QMEC, in its conclusion, encouraged the HIR Secretariat to take a holistic approach in their continual improvement actions for all projects under HIR. Overall, the panel views that there exist some form of system in the planning, execution, monitoring and improving of HIR projects, but recommends that those system to be maintained and some enhanced. Acknowledgements The UM HIR Steering Committee under the chairmanship of Tan Sri VC would like to acknowledge the work of the QMEC Auditing Team led by Prof. Dr. Fauza Ab. Ghaffar, Director of QMEC. The audit report will be further studied by the Committee in detail and the recommendations to improve the performance of HIR will be implemented. High Impact Research Annual Report 2012 UM HIR NEWS (2 NOVEMBER 2012) Professor Paul Williams, Head of the School of Molecular Medicine, University of Nottingham, United Kingdom, paid a 2-day visit to Dr. Chan Kok Gan, to review and evaluate the progress of their joint project on Bacterial Quorum Quenching. Professor Paul Williams is currently Professor of Molecular Microbiology in the School of Molecular Medical Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, U.K. Professor Williams’ research interests have primarily focused on bacterial cell-to-cell communication (‘quorum sensing’). Prof. Williams is a Thomson ISI highly cited author and has been invited to give plenary talks at over 60 international symposia worldwide. He has authored >280 experimental papers, invited reviews and book chapters, 10 patents filed, designated as ISI Highlycited.com Researcher (Microbiology) 2005 with H-index >68. His research group funding has >£25 million. He has published in numerous premier Tier 1 ISI-indexed journals: Science, Nature Medicine, Nature Protocols, Nature Biotech, Nature Genetics, PNAS, EMBO J, The Lancet Infectious Diseases, just to name a few. For his quorum sensing work Professor Williams was awarded the Royal Pharmaceutical Society’s Conference Science Medal (1992), the Pfizer Prize (1994), Society of General Microbiology Colworth Prize Lecture (2007) and his video film entitled “Investigating bacterial communication” which was awarded the silver medal at the 1999 Prix Leonardo Film Festival. Prof. Williams has served on the editorial boards of Environmental Microbiology, Journal of Bacteriology Microbiology, FEMS Microbiology Letters, Biofilms, International Journal of Medical Microbiology and Molecular Microbiology (advisory board). He has also been a member of the Biotechnology and Biological Sciences Research Council U.K. (Plants and Microbes Committee), the Medical Research Council U.K. Advisory Board, the Medical Research Council U.K. College of Experts, the Infection Group of the Society for General Microbiology and was a parent governor at Mornington Primary School, Nottingham U.K. During Prof. William’s visit, he gave a lecture entitled “Quorum Sensing and Pseudomonas - a tale of regulatory networks, multifunctional signal molecules and antibacterial targets”. In this lecture, Prof. Williams elaborated on the various signalling systems and their regulations in human opportunistic Pseudomonas, and the exploration of its quorum sensing as novel anti-bacterial targets. 169 170 High Impact Research Annual Report 2012 UM HIR NEWS (7 NOVEMBER 2012) HIR hosted a talk by a successful UM alumni, Prof. Dr. Kalai Mattee, who is presently attached to the Department of Molecular and Infectious Disease, Herbert Wertheim College of Medicine, Florida International University. The title of her talk was “Genes, Greens, and 65 Roses – The Pseudomonas aeruginosa Connection”. Summary P. aeruginosa is an opportunistic pathogen that causes a variety of severe and sometimes lethal infections of the respiratory tract, urinary tract, intestine, eyes, ears, and wounds. It has become a serious threat to immuno-compromised patients, and has become difficult to treat due to an increasing resistance (intrinsic and acquired) to multiple antibiotics. Chronic infection with P. aeruginosa remains the most common cause of morbidity and mortality among patients with cystic fibrosis (CF), an inherited genetic disease. Antibiotic therapy, with a mixture of aminoglycoside and ß-lactam antibiotics, is most often prescribed. However, the treatment often fails in CF patients due to the emergence of resistant strains. The talk delved briefly into the molecular mechanisms responsible for resistance and focused on alternative therapies (compounds of botanical and synthetic origin) to combat the disease. Professor Dr. Kalai Mathee is the First Founding Faculty Member and Founding Chair of the Department of Molecular Microbiology and Infectious Diseases, Herbert Wertheim College of Medicine, Florida International University since 2007. Kalai received her BSc (Genetics) and MSc (Microbial Genetics) degrees from the University of Malaya. She went on to complete her Ph.D. in Molecular Microbiology at the University of Tennessee, Memphis under the tutelage of Martha M. Howe, a renowned geneticist and former President of American Society for Microbiology. Her fascination with Pseudomonas aeruginosa and cystic fibrosis (CF) started in 1993 when she joined Dennis Ohman’s lab as a postdoctoral fellow. In 1999, she joined the Department of Biological Sciences at Florida International University as an Assistant Professor of Pathogenic Microbiology. Kalai has established a multi-faceted well-funded (~USD $3 Million) research program focusing on molecular pathogenesis in the model organism Pseudomonas aeruginosa that is responsible for the high morbidity and mortality in CF patients. She is well-respected nationally and internationally by researchers in multiple fields, including Pseudomonas pathogenesis, alternate therapy using botanicals, microbial biofilm development, regulation of prokaryotic transcription and phage molecular biology. She holds three patents and two licenses. She has published more than 55 articles and several book chapters in the fields of molecular microbiology, forensic science and bioinformatics in many high impact journals such as Annual Review of Microbiology (IF:14.3), Nano Letters (IF:13.2), PNAS (IF: 9.7), Nucleic Acids Research (IF:8.0), and PLoS One (IF:4.0) In 2011, for her commitment to excellence, Kalai was bestowed the highest honor in FIU, the Inaugural FIU President’s Council Worlds Ahead Faculty Award, in recognition of her outstanding achievement and a professor who makes an impact and exceeds expectations. UNIVERSITY OF MALAYA CENTRAL HIGH IMPACT RESEARCH (HIR) CORE RESEARCH FACILITIES 172 High Impact Research Annual Report 2012 UNIVERSITY OF MALAYA CENTRAL HIGH IMPACT RESEARCH (HIR) CORE RESEARCH FACILITIES In 2012 UM Central HIR core research facilities currently located in both ground floor and level 1 of HIR Building officially opened its doors to offer researchers in UM a wide range of state-of-the art instrumentation and technologies in various research fields. Training for the use of the instruments are arranged and only those who are trained will be al-lowed to handle the high end equipment. The core facilities are available on a pay-per-use or on packages with discounted rate basis to the whole UM community. For Frequent UM Users, HIR Central offers a range of Platinum, Gold and Silver packages and the fees. Currently, HIR Central Core Facilities support applications in the areas of Genomics, Cellomics, Proteomics, Bioinformatics and many others CFX96 Real-Time PCR System The CFX96™ Real-time PCR System runs with a 96 well block that can accommodate 0.2 ml tubes, strips or 96 well plate and can detect 5 different fluorescent dyes simultaneously. CFX 96 High-Resolution Melt analysis dedicated software (HRM) has extended the usefulness of quantitative real-time PCR methodology to detailed post-PCR sequence analysis, enabling a range of applications, such as mutation scanning, methylation analysis and SNP genotyping. Responsible Officer: Dr Ng Ching Ching QuantStudio 12K Flex Real-Time PCR System HIR QuantStudio 12K Flex Real Time PCR System is complete with the following features: Interchangeable Blocks for Maximum flexibility 96-well Fast Peltier-based Block 384-well Block Array Card Block Maximum multiplexing & chemistry options. Proven fluorescence detection with Enhanced OptiFlex® System (e.g. white light LED and 21 filter combinations for extremely accurate and sensitive data collection (excitation 450-760nm; emission 500-720 nm). Standard propriety dyes that are compatible include SYBR-Green®, VIC®, FAM®, ROX®, TAMRA® and NED®. Able to perform a multitiude of applications, in particular Taqman® assays Gene expression analysis. TaqMan® Gene Expression Assays are the most comprehensive set of quantitative gene expression assays available, providing more than 1.3 million primer/probe sets for 23 species, in four sizes, including your choice of FAM™ or VIC® dye labels. Custom assays are available for studying the expression of any gene or splice variant in any organism. SNP genotyping. The precision of TaqMan® probe–based chemistry makes SNP genotyping studies easy. Choose from over 4.5 million predesigned human and mouse TaqMan® SNP Genotyping Assays and 2,700 TaqMan® High Impact Research Annual Report 2012 DME Genotyping Assays, or Custom TaqMan® SNP Genotyping Assays, in various sizes. Copy number analysis. TaqMan® Copy Number Assays are a collection of over 1.6 million predesigned assays with genome-wide coverage for human, over 180,000 assays targeting exons for mouse, and Custom Plus and standard Custom TaqMan® Copy Number Assays when a predesigned assay is not readily available. MicroRNA and other noncoding RNA analysis. Innovative TaqMan® Assays and tools are available for long noncoding RNA quantification, miRNA profiling, pri-miRNA quantification, small RNA quantification, and targeted miRNA quantification. Responsible Officer: Dr Ng Ching Ching NucliSENS easyMag Total Nucleic Acid Extraction System An IVD-labelled automated system for total nucleic acid extraction from a variety of sample types and volumes. Descriptions: • Magnetic extraction based on the Gold standard BOOM technology (Silica particles) • Lysis can be done either on-board or off-board • Run Capacity: 1 – 24 samples per run • Samples Types: plasma, serum, Sample Type: whole blood, CSF, sputum, stool, BAL, swabs, dry blood spot, urine etc. • Turnaround time: about 40 – 60 minutes for 24 extractions Responsible Officer: Dr Tee Kok Keng Luminex 200TM Luminex 200 is a multiplex bead-based fluoroanalyzer. Powered by xMAP® Technology, this system enables you to multiplex up to 100 analytes in a single microplate well, using very small sample volumes. The system delivers fast and cost-effective bioassay results in many assay formats including nucleic acid assays, receptor-ligand assays, immunoassays and enzymatic assays. HIR Luminex 200 is located in Central Facility 2 and is completed with the following components: LX200 Analyzer XY Platform Sheath Delivery System] Luminex IS2.3 Software Xponent 3.1 Software Responsible Officer: Dr Tee Kok Keng 173 174 High Impact Research Annual Report 2012 Bioanalyzer 2100 The Agilent 2100 Bioanalyzer is an automated on-chip electrophoresis system for a wide range of applications: • On-chip flow cytometry: automated dual colour flow cytometric assays with chip-based kits, cell based fluorescence data • DNA sizing, DNA Quantification • RNA integrity, Quantification and small RNA Sizing • Protein sizing, quantification and purity This instrument is located in Central Facility 2, Level 1 of HIR Building and is routinely used as a quality control and quantitation device prior to Next Generation Sequencing. Responsible Officer: Dr Chan Kok Gan Tecan Microplate Reader I. Tecan Infinite M200 PRO with Quad 4 Monochromator II. Filter-based Tecan F200 Pro Tecan Microplate reader allows user to select any wavelength from UV to NIR, and to perform absorbance, excitation and emission scans. Users can access all wavelengths, and change from top to bottom reading, for easy measurement of multiplexed assays at the touch of a mouse click – no manual hardware changes are required Tecan Microplate Reader offers a wide range of biological assays and measurements including: DNA/RNA quantification • protein quantification • reporter gene and gene expression assays • cell viability and toxicity assays • cell-based assays • enzyme assays • ELISA • immunoassays • fluorescence and luminescence applications and many more Website : http://www.tecan.com Responsible Officer: Dr Chan Kok Gan High Impact Research Annual Report 2012 Microflex MALDI-TOF Mass Spectrometry System The system available in HIR is Bruker Microflex LRF MALDI-TOF Mass spectrometry System. This system is equipped with a 60 Hz nitrogen laser, gridless reflectron and microscope ion source and operating under the integrated user friendly Compass software. Microflex LRF MALDI-TOF is capable of measuring broad mass range of small molecule, polymer, protein, and peptide analytes. It is suitable for microbial identification and classification with library build up. HIR Microflex MALDI-TOF Mass Spectrometry System is configured with the following Software: • Mass Spectrometry Software Compass 1.3 for Flex • MALDI BioTyper 3.1 Software • BioTyper Reference Library • Bio Tools 3.2 – Software for protein data interpretation Currently, HIR MALDI-TOF is being used for microorganism identification Responsible Officer: Dr Loke Mun Fai & Dr Chan Kok Gan MACSQuant Flow Cytometer MACSQuant Flow Cytometer enables researchers to gather statistical data on large numbers of cells and use that information to correlate multiple parameters within a cell population. HIR MACSQuant Flowcytometer is equipped with three excitation lasers (violet 405, Blue 488, and Red 635 nm), two scatters (FSC, SSC) and up to eight fluorescent channels. The instrument is located in Central Facility 2, Level 1 HIR Building is able to analyse cells in single tube or from a 96 well plate. MACSQuant Flow Cytometry is an essential tool for researchers working in the field of molecu-lar interactions, pharmacokinetics, cell biology, systems biology, marine biology, biophysics Responsible Officer: Dr Ng Ching Ching & Dr Ea Chee Kwee 175 176 High Impact Research Annual Report 2012 HIR CENTRAL EQUIPMENT Summary of Charges & Responsible Officers for HIR Central Equipment (Set 1) No Responsible Officer 1 Bioanalyzer Expert 2100 2 Capillary Electrophoresis Dr Chan Kok Gan Dr Chan Kok Gan 3 CFX96 Real Time PCR 4 Present Location Unit of Measurement Charges (RM) UM User Non UM Frequent UM User User Central Facility 2, HIR Per sample 10.00 50.00 400/50 samples Bilik Khas 3, HIR Per sample 50.00 100.00 1,500/50 samples Dr Ng Ching Ching Central Facility 2, HIR Per hour slot 10.00 50.00 950.00/100 hrs, 1,800.00/200 hrs, 3,000.00/500 hrs F200 Pro Microplate Reader Dr Chan Kok Gan Central Facility 2, HIR Per plate of 96 FOC wells, Quick Read Overnight Read 50.00 5 GC-MIDI Dr Chan Kok Gan Bilik Khas 3, HIR Per sample 15.00 50.00 700.00/50 samples 6 GC-MS Dr Loke Mun Fai Bilik Khas 3, HIR Per hour slot 50.00 80.00 700.00/20 hrs, 1,000.00/50 hrs 7 Rotary Evaporator Dr Chan Kok Gan NPC Lab, IPS Per hour slot 30.00 100.00 2,500.00/100 hs, 4,000.00/200 hrs 8 LC/MS/MS Triple Quadrupole Mass Spectrometer Dr Chan Kok Gan Bilik Khas 3, HIR Per 3-hour slot 300.00 800.00 Per 8 working hrs slot 500.00 1,500.00 2,200.00/5 x 8 working hrs slot 200.00 500.00 100.00 1,500.00/50 plates 7,500.00/100 hrs, 14,000.00/200 hrs 9 Luminex 200 Dr Tee Kok Keng Central Facility 2, HIR Per 3-hour slot 10 M200 Pro Microplate Reader Dr Chan Kok Gan Central Facility 2, HIR Per plate of 96 FOC wells, Quick Read Overnight Read 50.00 1,500.00/50 plates 11 MacQuant Flow Cytometry Dr Ng Ching Ching Central Facility 2, HIR Per 3-hour slot 200.00 500.00 6,000.00/50 slots, 10,000.00/100 slots 12 Optima XPN100 Ultracentrifuge Dr Ng Ching Ching Bilik Khas 2, HIR Per hour slot 10.00 50.00 950.00/100 hrs, 1,800.00/200 hrs, 3,000.00/500 hrs 13 Quantstudio 12K Real Time PCR Dr Ng Ching Ching Central Facility 2, HIR Per hour slot 30.00 100.00 2,500.00/100 hr slot, 4,000.00/200 hr slot 9,000.00/500 hr slot 14 Qubit 2.0 Fluorometer Dr Tee Kok Keng Central Facility 2, HIR Per sample 10.00 25.00 300.00/50 samples 500.00/100 samples 15 Ultra High Performace Liquid Chromatograph (UHPLC) Dr Chan Kok Gan Bilik Khas 3, HIR Per 3-hour slot 15.00 50.00 600.00/50 slot 1,000.00/100 slot 16 Biolog Omnilog GenIII Combo Plus System Dr Chan Kok Gan Central Facility 1, HIR 1 Day Slot 100.00 400.00 17 Comprehensive Bacterial Dr Chan Kok Gan Bioluminescence Imaging System Bilik Khas 2, HIR 3 Hour Slot FOC 150.00 1 Day Slot 50.00 300.00 Fermenter Bilik Khas 2, HIR 3 Hour Slot FOC 100.00 1 Day Slot FOC 200.00 3 Hour Slot FOC 100.00 1 Day Slot FOC 200.00 3 Hour Slot FOC 100.00 1 Day Slot FOC 200.00 per 8 sample slot (minimal) 320.00 800.00 18 Name of Equipment Dr Chan Kok Gan 19 Vacuum Concentrator Dr Chan Kok Gan Makmal NPC 20 Fluorescence Microscope Dr Chan Kok Gan Central Facility 2, HIR 21 easyMag Liquid Handling System Dr Tee Kok Keng Central Facility 2, HIR 1,200.00/10 slots 100.00 800.00/10 Days Slot 200.00/100 Hour 100.00/10 days 100.00/10 days 100.00/10 days 1824.00/48 samples (5% Discount) Updated as of 22 Dec 2012 FINANCIAL STATEMENT HIR FACULTY CONTACT PERSON OF HIR SECRETARIAT PHOTO GALLERY ENGINEERING SCIENCE DENTAL COMP. SCIE. CHANCELLORY SOC. SCIE. BUILT ENV. 2 3 4 5 6 7 8 TOTAL : Balance of Cycle 3 Secretariat (Balanced Revised 68%) MEDICINE Faculty 1 No ENGINEERING SCIENCE DENTAL COMP. SCIE. CHANCELLORY SOC. SCIE. BUILT ENV. 3 4 5 6 7 8 TOTAL : Balance of Cycle 3 108,368,721 - - 6,289,250 3,201,200 15,092,351 0 65,108,120 9,317,851 630,077 692,606 1,589,967 4,931,162 1,474,040 99,050,870 5,659,173 2,508,594 13,502,384 8.60 10.02 21.64 10.53 0.00 7.57 7.89 5 53 - - 2 6 13 0 27 34.20 43.41 17.53 35.88 33.71 31.79 26.97 % SPENT 75 - - 9 6 8 12 23 17 No. of projects *As of 31st December 2012 204,108,638 59,044,810 7,526,710 8,459,868 39,785,793 36,040,211 53,251,246 RM Balance No. of projects 108,325,855 45,297,138 1,599,781 4,734,885 20,228,710 16,797,258 19,668,084 Total Expenditure % SPENT 13,514,443 2,271,580 294,653 233,379 7,046,900 60,176,958 0 662,634 RM CAPEX 3,005,298 17,203,760 RM Balance 94,811,412 43,025,559 1,305,127 4,501,506 13,181,810 13,791,960 RM 18,677,800 RM OPEX Expenditure 19,005,450 RM 316,764,010 4,329,517 - - 104,341,948 9,126,490 13,194,753 60,014,503 52,837,469 72,919,330 Expenditure 64,887,541 36,806,500 300,500 425,000 10,910,735 5,482,771 10,962,035 RM CAPEX Total Allocation Allocation for Cycle 2 251,876,469 4,329,517 67,535,448 8,825,990 12,769,753 49,103,768 47,354,698 61,957,295 RM OPEX Allocation for Cycle 1 Secretariat (Balanced Revised 68% ) MEDICINE 2 Faculty 140 - - 10 13 22 13 62 20 No. of projects 1 No 590,156,460 - - 125,000,000 27,268,000 28,287,330 79,904,130 200,000,000 129,697,000 RM Proposed & Approved by MOHE ALLOCATION & EXPENDITURE AS AT 31 DECEMBER FOR HIR-MOHE FINANCIAL STATEMENT 178 High Impact Research Annual Report 2012 High Impact Research Annual Report 2012 HIR FACULTY SECRETARIAT HIR FACULTY OF MEDICINE From left to right Siti Fatimah Zahra Mohd Anuar Amirul Asraf Mohd Jurami Nur Fazlin Mahfodz Secretariat, High Impact Research Grant, Office of the Dean, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur hirgfom@ummc.edu.my SECRETARIAT HIR FACULTY OF ENGINEERING From left to right Mariam Ali Anis Yusnida Zakaria Mohd Faiz Ibrahim Norsaidin Mahusin Muhammad Khlaid Hashim Secretariat, High Impact Research Grant, Deputy Dean (Research) Office, Level 4, Engineering Tower, Faculty of Engineering University of Malaya, 50603 Kuala Lumpur Enghirmohe@gmail.com 179 180 High Impact Research Annual Report 2012 SECRETARIAT HIR FACULTY OF SCIENCE Nur Syahrinar Anuar Secretariat, High Impact Research Grant, Office of the Dean, Faculty of Science, University of Malaya, 50603 Kuala Lumpur fs.um.edu.my SECRETARIAT HIR FACULTY OF DENTISTRY From left to right Norshida Abdul Manan Mariah Mansor Nur Syafiqah Abd Malek Secretariat, High Impact Research Grant, Research Management Centre(RMC), Level 6, Postgraduate & Research Building, Faculty of Dentistry University of Malaya, 50603 Kuala Lumpur rmc_dental@um.edu.my SECRETARIAT HIR FACULTY OF COMPUTER SCIENCE & INFORMATION TECHNOLOGY From left to right Muhamad Afiq Zaini Alamar Lily@Sharipah Noriah Zainal Abidin Secretariat, High Impact Research Grant, Office of the Dean, Faculty of Computer Science & Information Technology, University of Malaya, 50603 Kuala Lumpur www.fsktm.um.edu.my High Impact Research Annual Report 2012 CONTACT PERSON OF HIR SECRETARIAT VC’s Office Siti Zawahir Zubir 03-7967 3400 zawahirzubir@gmail.com VC’s Office Azbullah Che Ibrahim 03-7967 3231 azbullahibrahim@gmail.com VC’s Office Nur Ain Valerie Cassera Binti Rapoi 03-7967 7763 navalcas@um.edu.my VC’s Office Hamizah Husain 03-7967 7791 hamizah_husain@um.edu.my VC’s Office Sarina Ramli 03-7967 7790 rienaramli@um.edu.my VC’s Office Nabilah Ahmad 03-7967 2092 nabilahahmad@um.edu.my VC’s Office Alsaddam Suhaimi 03-7967 2092 alsaddam@um.edu.my Bursar Haliza Harun 03-7967 3205 halizahr@um.edu.my Assistant Bursar Norshahidayu Ali 03-7967 3270 shahidayu@um.edu.my Procurement Unit Puteri Heirzerein Megat Zamry 03-7967 6996 put3mz@um.edu.my Payment Unit Dr. Noor Hashim Taib 03-7967 3403 nhashim@um.edu.my Faculty of Medicine Siti Fatimah Zahra Mohd Anuar 03-7967 7515 fatimah_zahra@ummc.edu.my Faculty of Medicine Amirul Asraf Mohd Jurami 03-7967 7515 amirulasraf@um.edu.my Faculty of Medicine Nur Fazlin Mahfodz 03-7967 7515 fazlin211@ummc.edu.my Faculty of Medicine Siti Falika Ahmad 03-7967 7515 sitifalika3107@gmail.com Faculty of Engineering Norsaidin Mahusin 03-7967 7684 norsaidin@um.edu.my Faculty of Engineering Muhammad Khlaid Hashim 03-7967 7684 khlaid@um.edu.my Faculty of Engineering Mohd Faiz Ibrahim 03-7967 7684 fais8821@um.edu.my Faculty of Engineering Rosnani Jaafar 03-7967 7684 rosnani_jf12@um.edu.my Faculty of Engineering Anis Yusnida Zakaria 03-7967 7684 anizyusnida@um.edu.my Faculty of Dentistry Intan Suhana Hamid 03-7967 6454 intansuhana@um.edu.my Faculty of Dentistry Norshida Abdul Manan 03-7967 6454 norshida79@um.edu.my Faculty of Dentistry Mariah Mansor 03-7967 6454 mariahm@um.edu.my Faculty of Science Nur Syahrinar Anuar 03-7967 6758 rien_syerena@um.edu.my Faculty of Science Noor Azlin Che Din 03- 7967 4024 azlin_cd@um.edu.my Faculty of Computer Science & Information Technology Muhamad Afiq Zaini Alamar 03-7967 6382 afiq.almar@um.edu.my 181 182 High Impact Research Annual Report 2012 High Impact Research Annual Report 2012 ryo.hh.12 183 184 High Impact Research Annual Report 2012 2 High Impact Research Annual Report 2012 Design and Printed by University of Malaya Press 50603 Kuala Lumpur
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