Volume 1 - Centre de recherche Institut universitaire en santé

Transcription

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LET US JUST CONSIDER whether we might not be able to escape
from the anxiety into which the dangerous power of thought is now plunging us
— simply by improving our thinking still more. And to do this let us begin by
climbing up till we tower over the trees which now hide the forest from us; in other
words let us forget for a moment the details of the economic crises, the political
tensions, the class-struggles which block out our horizon, and let us climb high
enough to gain an inclusive and impartial view of the whole process of hominization1
as it has advanced during the last fifty or sixty years.
From this vantage-point what do we first notice? And if some observer were to
come to us from one of the stars what would he chiefly notice?
Without question, two major phenomena :
– the first, that in the course of half a century technology has advanced with
incredible rapidity, an advance not just of scattered, localized technical
developments but of a real geotechnology which spreads out the close-woven
network of its interdependent enterprises over the totality of the earth;
– the second, that in the same period, at the same pace and on the same scale
of planetary co-operation and achievement, science has transformed in every
direction — from the infinitesimal to the immense and to the immensely
complex — our common vision of the world and our common power of action.
Pierre Teilhard de Chardin,
Hymn of the Universe, Harper & Row,
1961, chapter 4, number 44.
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TABLE OF CONTENTS
A word from Dr. Michel Maziade ................................................................................................ 3
A word from Mr. Réjean Cantin and Mr. Michel Gervais .............................................................. 6
A tradition, a mission .................................................................................................................. 7
From tradition to innovation ........................................................................................................ 7
Our integrated action plan .......................................................................................................... 7
The extent of our mission............................................................................................................ 7
Key indicators of scientific and technological activities ................................................................ 9
A centre in a strategic niche .................................................................................................... 10
Knowledge transfer, university-industry partnership and clinical research .................................. 13
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Head office .............................................................................................................................. 15
List of members on the board of directors ................................................................................ 16
List of researchers .................................................................................................................... 17
List of students enrolled in graduate studies.............................................................................. 18
List of staff ................................................................................................................................ 19
International collaborators ........................................................................................................ 20
2601, chemin de la Canardière, Québec (Québec) G1J 2G3 CANADA Phone : (418) 663-5741 Fax : (418) 663-9540 www.crulrg.ulaval.ca
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Photo : Marc Robitaille
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Centre de recherche Université Laval Robert-Giffard
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A WORD FROM DR. MICHEL MAZIADE
Our researchers are part of the worldwide revolution now going on in
neuroscience and mental health research where convergence, interdisciplinarity and transfer of acquired knowledge come together to give
patients concrete applications. The neuroscience and neuropsychiatry are
now beginning to understand the molecular basis of neuronal functioning
and its relation with the causes of neuropsychiatric diseases. By becoming
interlaced, the biological, engineering, social, clinical and computer sciences
promise to speed up detection of the early stages of these illnesses. These
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Figure 1
Progression of Research Grants Obtained Through
Several Contests from National and International
Scientific Organizations
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Our recent accomplishments include : a) the creation of new circuits of
research extending into cellular and molecular neurobiology; b) the development
of a solid sector in cognitive psychology and neuropsychology as applied to
different diseases; c) a recruiting campaign that recently attracted and
repatriated to Canada some 15 new researchers; d) the construction of a
unique neurophotonic center in Canada; e) the setting-up of a training
program in neurophysics subsidized by the Canadian Institutes of Health
Research (CIHR); f) the filing for patents for the enhanced value of discoveries
in cellular neurobiology and genetic psychiatry; g) a number of discoveries
pertaining to schizophrenia, pain, sleep disorders, neurogenesis, cognitive
behavioral treatment in chronic insomnia and many others (see Volume 2
for more details); and h) a more widely expanded network of national and
international collaborating research teams from fifty or so North American
and European universities.
Clinical research remains the building block for establishing a solid
relationship between fundamental research laboratories and the clinic.
Therefore, we have developed several collaborations in fields such as
clinical and fundamental research, neuropsychiatric diseases, neuroscience,
neuronal imagery, neurogenesis, and psychiatric genomics, with international
pharmaceutical companies like AstraZeneca, Sanofi-aventis, Eli Lilly,
GlaxoSmithKline, Lundbeck, Janssen, and Shire.
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Our research programs are highly competitive thanks to the dedication of
our research team whose excellence is now renowned. To illustrate, one
need but glance at the research grants obtained by our scientists to see
that our annual rate has more than doubled over the last years with peerreviewed grants approaching 6 M$. (See Figures 1-2.) Furthermore, the
quality of the work at the CRULRG and the different inter-methodological
projects have attracted more than 23 M$ from the infrastructure and technological equipment funds of the Canada Foundation for Innovation (CFI)
and the Quebec Government. This investment will allow an extra
7,000 square meters for state-of-the-art laboratories. Regarding our student
researchers, we now have 174 from fifteen Laval University departments
and nine faculties. (See Figure 4.)
Four Canada Research Chairs have been obtained in four exceptional and
complementary fields : one in sleep disorders (Charles M. Morin, professor
of psychology, Laval University), one in the genetics of neuropsychiatric diseases (Michel Maziade, professor of psychiatry, Laval University), one in
postnatal neurogenesis (Armen Saghatelyan, professor of psychiatry, Laval
University), and one in biophotonics (Daniel Côté, professor of physics,
Laval University).
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Dr. Michel Maziade
Scientific Director
The socioeconomic impact of brain
disorders is significant and represents a
health problem of the highest order,
generating annual costs of around
35 billion dollars in Canada. At the dawn
of worldwide progress and explosive
breakthroughs in the understanding of
brain functioning and the causes of
neuropsychiatric illnesses, the different
teams of the Centre de recherche
Université Laval Robert-Giffard (CRULRG)
have formed a united front to tear down
the walls that keep the brain and the
neurone cloaked in mystery.
Excellence – Convergence – Competitiveness – Interdisciplinarity – Here and elsewhere in the world!
Figure 2
Research Grants Obtained Through Several Contests
From National and International Scientific Organizations
Figure 3
Investments Related to the Infrastructures (Laboratories and Equipment) 2000 - 2006
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A regional economic driving force : investment growth
The CRULRG is, without a doubt, highly competitive and, hence, it saw its peer-reviewed grants increase 100 % to
reach 6 M$ within 5 years. Also, the Centre’s high quality research work and its different inter-methodological
projects have been recognized by both The Canada Foundation for Innovation and the Quebec Government and this
has materialized into a 23 M$ contribution for infrastructures and technological equipment. The Centre has invested these
funds for equipment specialized in the investigation of the neurone and the brain.
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Figure 4
The CRULRG Students and Researchers are From
Different Faculties and Departments of Laval University
Faculty affiliation
Departmental affiliation
Medicine
Anatomy and Physiology
Medicine
Social and Preventive Medicine
Otorhinolaryngology and ophtalmology
Psychiatry
Rehabilitation
Biochemistry and Microbiology
Biology
Mathematics and Statistics
Physics, Physical Engineering and Optics
Psychology
Social Services
Anthropology
Sociology
Science of Food and Nutrition
Science and Engineering
Social Sciences
Agriculture and Food
Dentistry
Pharmacy
Philosophy
Nursing Science
Theology and Religious Science
Formal training of future researchers
With the variety of subjects to tackle and the diversity of methodologies, students can
cover the whole spectrum of research from the molecule to the human element,
including the organization of services and the health of populations. (For more
information on these subjects, consult Volume 2 or go to www.crulrg.ulaval.ca on the
web.) These students are registered in graduate studies at Laval University and come
from nine different faculties and fifteen different departments.
Figure 5
Growth in the Numbers of the Research Staff and Other
Employees of the CRULRG
discoveries will allow us to diagnose neuropsychatric diseases through
molecular mechanisms instead of just focusing on the symptoms. During
the next decade, cures and medication for brain disorders will come from
new ways of seeing, new formulations, new paths, and unimaginable
discoveries will be based on new generations of biomedical and medico-social
approaches. The CRULRG has pledged to devote its efforts to reducing the
interval that follows new discoveries and their innovative applications as
treatments, diagnostic methods and prevention.
As the CRULRG proceeds with its mission, it seeks a balance between basic
research and applied research on populations by catalyzing the synergy of
professions, methods, technologies and study populations in order to
improve the treatments in the fields of brain disorders, in children, in adults
and the elderly, thus contributing to the economic growth of Quebec and
Canada. In this 21st century, innovation in mental health research and the
neuroscience is fundamental for the health and well-being of Quebec and
Canadian citizens. Well enrooted in its strategic fields and in full-growth
mode, the CRULRG, already an economic driving force for the region, has
become a high technology institute with ties to numerous governmental,
university and scientific partners at the Canadian and international level, as
well as to the business sector. The CRULRG also serves as an efficient local
model of the Institute of Neurosciences, Mental Health and Addiction, one of
the Canadian Institutes of Health Research (CIHR). Of equal importance is
the CRULRG’s ever present mission to keep up its interfaculty teaching at the
university level.
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I praise the perseverance and determination of the 352 builders of the
Centre de recherche Université Laval Robert-Giffard whose reputation has
now reached international proportions and conferred upon Quebec City the
honors of becoming one of the capitals of brain and neurone research. We
thank the governments of Quebec and Canada for their support. It is also
very important to mention that the CRULRG scientists are very grateful to
have the support of “Les Sœurs de la Charité de Québec”. Thanks to this
congregation, the CRULRG has seen tremendous growth and looks forward
to a promising future.
Through the continuous efforts of our researchers, we seek to kindle the fires
of hope in the hearts of all those who suffer.
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At the Centre, we currently have over 350 people when we include the administrators.
Some of them are Laval University research-professors with international reputations,
near 175 others are part of the research student body in high-tech training, and
others are highly trained fundamental and clinical researchers.
Michel Maziade, M.D., FRCPC
Scientific Director
A staff highly specialized in the neurone, brain and brain disorders
A WORD FROM MR. RÉJEAN CANTIN
AND MR. MICHEL GERVAIS
PROMISING SCIENTIFIC BREAKTHROUGHS
IN A
CONSTANTLY GROWING CENTER
The excellence of the Center’s research, the outstanding competitivity
of our scientists as well as the interdisciplinarity of their resources
underline the professional maturity and the research strength of the
Center. In fact, over the years, le Centre de recherche Université
Laval Robert-Giffard (CRULRG) has expanded its worldwide reputation
for its research in brain disorders and mental health, a field that is
known to lack both scientific research and funds.
Mr. Réjean Cantin
The prevalence of infantile, adult and geriatric neurocognitive
diseases in the Canadian population is significant. For now, most of
these illnesses have no curative treatment. Despite having successfully
recruited top quality researchers and a highly specialized staff, the
mission remains colossal. The CRULRG, through its new scientific
breakthroughs in mental health, neuropsychiatry and neuroscience,
allows us to hope for tangible repercussions for the Quebec and
Canadian population.
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Mr. Michel Gervais
Michel Gervais
General Director
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Réjean Cantin
President of the Board of Directors
2. Pursue the recruiting of the best researchers throughout the world and
bring home the Quebec researchers working abroad;
3. Increase the participation of our researchers in international
research networks;
4. Ensure the training of new researchers by focusing on the training
of students and the development of inter-methodological and
inter-technological abilities;
5. Complete the development of high-tech infrastructures to meet our
scientific challenges.
6. Increase the transfer of knowledge and innovations and forward these
to health, educational and social departments.
• At a worldwide scale, more than 450 million people suffer from mental
disorders(1);
• In industrialized countries, anxiety disorders, personality disorders,
major depressive and eating disorders are amongst the 10 main causes
of disabilities(2);
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• There are more than 24 million schizophrenic patients, 90 million alcoholic
patients and about 121 million people suffering from depression;
already, in the middle of the nineteen nineties, the World Health
Organization and the National Bank showed that nervous traumas,
degenerative neurologic illnesses, psychiatric and mental disorders, as
well as memory and cognition dysfunctions, represented at least 25 %
of the economic burden attributable to illnesses;
• 90 % of all hospitalizations for neuropsychiatric diseases take place in
general hospitals;(3)
• The direct costs associated with the treatments of neuropsychiatric
illnesses (hospital, establishment, medical care and medication) have
reached 6.3 billions.(1) In 2001, a study conducted by Health Canada
concluded that mental illnesses were amongst the most expensive in
Canada, representing a burden of nearly 35 billion Canadian dollars.
(1) The world health report 2001, Mental Health : New understanding, new hope, World Health
Organization, 2001, 178 pages.
(2) The Economic Burden of Mental Health Problems in Canada, in Chronic Diseases in Canada,
Public Health Agency of Canada, 2001, 22:1, 40 pages.
(3) Health Canada, Report on mental disorders in Canada, Ottawa, Canada, 2002, 108 pages.
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1. Accelerate scientific research programs for a better comprehension of
the biological bases of brain functioning and brain disorders;
THE EXTENT OF OUR MISSION
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OUR INTEGRATED ACTION PLAN :
AN INSTITUTE THAT WELCOMES
AND REPATRIATES THE BRAINS
OF THE COUNTRY
The shrinking of the gap separating fundamental neuroscience and
neuropsychiatry is one of this century’s great challenges in mental health.
Huge progress has been accomplished by neuroscience and neuropsychiatry.
However, by having worked in parallel instead of together, a rift ensued and
the relation between mental health, on the one hand, and brain functioning,
on the other, has remained misunderstood. The mission of the CRULRG
now focuses around this challenge. The study of neurones and brain
functioning requires concerted action. By working together, researchers
from several specialized fields are creating new ways of doing things and
give hope to the patients and their families.
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The rich century-long history of Robert-Giffard Hospital has been marked
by a constant quest for excellence and for the best means to relieve brain
disorder sufferings. In 1983, “Les Sœurs de la Charité de Québec” were
committed to improving the general conditions at their mental hospital and
to keep up with the progress made by science and modern experiments to
improve patients treatments. More than a century ago, the objective of defining
medical care according to science and innovation was already present in
the institution. In 1923, the sisters asked that the hospital be affiliated with
Laval University. Today, le Centre de recherche Université Laval RobertGiffard perpetuates the underlying original mission, and it now focuses on
seeking out the causes and treatments of infantile, adult and geriatric
neuropsychiatric disorders, by means of a high-tech institute on neurone
and brain research.
FROM TRADITION TO INNOVATION
A TRADITION, A MISSION
The CRULRG has built a solid reputation at the national
and international levels for its research work on the
following diseases and disorders :
• Bipolar disorder
• Autism
• Neurodegenerative diseases
• Huntington’s chorea
• Parkinson’s disease
• Dementia and Alzheimer’s
disease
• Pigmentary retinal dystrophy
• Schizophrenia
• Manic-depressive psychoses
• Amyotrophic lateral sclerosis
• Depression
• Attention deficit disorder
• Chronic pain
• Anxiety disorders
• Epilepsy
• Eating disorders
• Gilles de la Tourette’s
syndrome
• Sleep disorders
• Pathological gambling
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• Alcoholism
KEY INDICATORS OF SCIENTIFIC AND TECHNOLOGICAL ACTIVITIES
• Sleep, biorythms and chronobiology in humans
• Neurophotonics
Sleep disorders, clinical trials, epidemiology, seasonal depression, eye
diseases, electrophysiology of vigilance states.
Application of the physical properties of light for neuronal imaging, and of
the physics of material and nanotechnologies for the study of neuronal
and synaptic biology.
• Psychiatric genomics and genetics
Genetics epidemiology for identification of susceptibility genes involved in
schizophrenia, depression and attention deficit disorder. Patents on DNAbased diagnostic tests for schizophrenia. DNA bank and large populationbased samples. Mathematical models for interactions among genes, and
between genes and the environment.
• Neuropsychopharmacology
Clinical research in schizophrenia, depression, attention deficit disorder,
Alzheimer’s disease.
• Postnatal neurogenesis
Neurotransmission, neural progenitors, differentiation and migration,
synaptogenesis, neuron replacement therapies for brain diseases.
• Neurodegenerative diseases and aging
Parkinson’s disease, Huntington’s disease, epilepsy, retinal diseases,
gene therapy, Alzheimer disease.
• Molecular neurobiology
Molecular basis of neuron physiology and neurotransmission, cell signaling,
neural plasticity, cell differentiation and central nervous system development.
• Pain
Cellular and molecular biology and physiology of chronic pain, mechanisms
underlying neuropathic pain by altered spinal chloride homeostasis.
• In vivo and in vitro electrophysiology
Neuronal transmission, epilepsy, functional organization of cortical
diencephalic and mesencephalic regions, cell signaling, development.
• Neuropsychology and cognitive sciences
Episodic memory, semantic memory, working memory, executive
functions, attention, verbal functions, and language skills.
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• Neuropsychopathology and clinical neuropsychiatry
Schizophrenia, depression, apathy, anxiety, impulsivity, psychosis, delirium,
personality disorders, attention deficit disorder/hyperactivity.
Further details can be found in Volume 2 and at www.crulrg.ca
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A CENTER IN A STRATEGIC NICHE
Genomics and Statistical Modelization Applied to Psychiatric Genetics –
Systemic Cellular and Molecular Neurobiology – Applied Electrophysiology and
Behavioral Neuroscience – Evaluative and Clinical Research
(More details are offered in Volume 2)
The neurobiological basis of central nervous system
development, circuitry, plasticity and degeneration
Our sector of systemic, cellular and molecular neurobiology is actually
experiencing an impressive development by combining, amongst other
things, in vivo and in vitro electrophysiological approaches with photonic
techniques to study, at the cellular and molecular levels, the structure,
function and plasticity of neuronal circuitry in both health and disease. Many
of our discoveries have led to several improvements in the fields of
neuropsychiatry, neuronal circuitry, postnatal neurogenesis and synaptic
plasticity. By bringing together the CRULRG’s expertise in photonic
techniques, Laval University’s know-how in optics, photonics and laser
sciences and McGill’s high expertise in materials, a new high-tech platform
was needed and the CRULRG’s Neurophotonic Center was born. This
platform supplies the researchers with new potent tools, leading to new
experiments, up to now inaccessible, and helps them to maximize the use of
new animal models to understand the functioning of the brain and eventually
the illnesses. These new approaches will delve into the molecular aspects of
neuronal communication in healthy and pathological systems and also into
cellular and molecular neuroimagery. By taking advantage of the properties
of light and nanotechnologies, innovative tools are being created to better
investigate the particularly fragile nervous tissues.
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Laval University’s psychiatric genomics program has increased its international
exposure by the identification of defective genes for schizophrenia and
bipolar disorder. This research relies on an intelligent database, unique in
the world, the information of which was gathered over a period of 20 years
and which includes several thousand subjects from about forty multigenerational
families. This database, which keeps a detailed and continuous clinical
evaluation of each individual, is connected to a permanent DNA bank,
allowing for various analyses linked to genetics. Many of the extended
phenotype measures taken from these individuals help to capitalize on the
linkage signals observed in our samples, to study more deeply the relation
between the illness and the genotype as well as to better understand the
regulation and the expression of the genes associated with mental health
problems. The discovery of several vulnerable genomic sites in our population
confirms an oligonenic (implying several genes) model for schizophrenia
and bipolar disorder. Our hypothesis that several genetic mechanisms are
shared between two illnesses is confirmed and allows for several innovative
research hypotheses on the causes of these two syndromes. This now
opens the way to new opportunities that focus on the children at high risk
of developing the disease.
Psychiatric genetics, electrophysiological cognitive
endophenotypes and statistical modelization of
genetic effects
Brain diseases that appear during adolescence and in early adult life could
be linked to a developmental problem encountered during early periods of
brain development. According to a generally accepted working hypothesis,
such diseases would result from a deficiency in the synaptic remodeling of
certain brain circuits. Hence, a better knowledge of synaptic signaling in
different neuronal networks is needed for a better understanding of the
neurochemical basis of brain diseases and for the development of effective
pharmacological treatments of different psychiatric disorders.
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Synaptic signaling and remodeling
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The dogma stipulating that neurons are no longer generated after birth has
been invalidated and there is now solid evidence that new neurons are
produced in specific brain areas throughout adulthood. The existence of
brain regions capable of generating neurons during adult life offers unique
opportunities to develop new therapeutic avenues for the treatment of
cognitive as well as neurodegenerative diseases.
Mental and neurodegenerative disorders can stem from strokes, head
traumas, inflammatory problems or viral infections and even from one’s
genetic background.
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Postnatal neurogenesis
Damage, degeneration and regeneration
of the brain
Our capability to analyze the electrophysiological properties of identified
neurones and to mark these neurones through a juxtacellular approach
enables us to increase our power of analysis when combining neuroanatomic
and neurochemical approaches with existing microcircuitry analysis but
including the study of new circuitry arising in the adult through postnatal
neurogenesis. By coupling neurochemistry, axonal tracing, postnatal neurogenesis and neurotrophic factors administered through viral vectors to the
post-mortem material stored in CRULRG’s human brain bank, researchers
can further their investigation of brain microcircuitry and neuromodulation to
a level never reached before.
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THANKS TO THIS VAST ARRAY OF
NOVEL TECHNOLOGICAL APPROACHES,
IT IS NOW POSSIBLE TO TEST
RESEARCH HYPOTHESES WHICH
WERE OUT OF REACH JUST A FEW
YEARS AGO.
KNOWLEDGE TRANSFER,
UNIVERSITY-INDUSTRY PARTNERSHIP
AND CLINICAL RESEARCH
Our research center, as a Canadian medical and scientific institute, offers
a stable environment able to focus on excellence, thus giving the highly
qualified personnel, each involved at different levels of the research
process, the opportunity to develop those skills necessary to excel.
Furthermore, the center seeks to encourage the development of
entrepreneurial skills so that the process of transfer of technology and
specialized knowledge to the private sector is facilitated, the outcome of
which benefits the region (Quebec City) and the country itself (Canada)
through job creation and improved products.
In the field of memory and cognitive disorders, we favor the use of cognitive
psychology to characterize normal cognition and to evaluate and characterize
cognitive deficits in various brain pathologies, such as dementia, major
depression, schizophrenia and attention deficit syndrome. In this context,
studies are currently being undertaken to understand the effect of
pharmacological and psychosocial treatments on the cognitive and behavioral
deficits encountered in Alzheimer’s disease.
Regarding evaluative and psychosocial research, we are actively collaborating
with the CSSS de la Vieille Capitale (Quebec City’s Health and Social
Services Center) in a vast research program that aims at understanding
ethical problems involved in the delivery of health care and services to
patients suffering from mental health problems as regards their social
inclusion and recovery.
Our scientists are also studying the pathophysiology of sleep disorders
(insomnia) and circadian rhythms (night work). The research methodology
combines electrophysiology (retina evoked potentials and cognitive
polysomniography), neuropsychology and photobiology. Several clinical
studies have been designed to improve the cognitive-behavioral treatment
of sleep disorders and to use the biological action of luminotherapy and the
development of new light sources to manipulate the biological clock.
Finally, we are combining genetic, neuropsychological, familial and
organizational approaches to evaluate and treat psychiatric disorders in
children. This research program is undertaken in collaboration with HôtelDieu de Lévis and also involves studies pertaining to the development of
psychopathologies such as autism.
Worldwide ramifications
Having achieved international reputations for the excellence of their work,
our researchers, in both clinical research and fundamental research, are
now collaborating on a number of scientific projects with different countries
and experiencing a phenomenal increase of the publications of their works
in the most prestigious scientific magazines and journals of the world. (See
details in Volume 2 and on website www.crulrg.ulaval.ca.) By being highly
competitive and businesslike while yet embracing an academic and socioeconomical responsibility, the CRULRG has created a strategic niche at the
regional, national and international levels.
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Further details can be found in Volume 2 and at www.crulrg.ca
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Comité de direction : André Parent Ph. D., Michel Maziade M.D., Marc-André Roy M.D., Yves De Koninck Ph. D.
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HEAD OFFICE
The Genetic Psychiatry Unit
Michel Maziade, M.D., FRCPC
Director of the genetic psychiatry unit
Director of the Centre de recherche Université Laval Robert-Giffard since 1987
Since 1998, Chair of the Department of psychiatry at Laval University
Since 2001, Chairholder of the Canada Research Chair in the genetics of neuropsychiatric disorders
The Cellular Neurobiology Unit
Yves De Koninck, Ph. D.
Director of the cellular neurobiology unit
In 2001, he received the Early Career Award from the Canadian Pain Society
Since 2001, he is in charge of the Québec network of pain research
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The Systemic Neurobiology Unit
André Parent, Ph. D.
Director of the systemic neurobiology unit
Since 1994, he is a member of the Academy of Science of the Royal Society of Canada
In 2002, he won the Prix Wilder-Penfield, Quebec’s highest honor, awarded for achievement in biomedical sciences
The Evaluative and Clinical Research Unit
Marc-André Roy, M.D., FRCPC
Director of the evaluative and clinical research unit
From 2002 to 2004, he held a National Alliance for Research on Schizophrenia and Depression
(NARSAD) Yound Investigator Award
Since 2004, he is Vice-President of the Association québécoise des programmes pour premiers
épisodes psychotiques (the Québec Association for programs for first psychotic episodes)
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LIST OF MEMBERS
ON THE BOARD OF DIRECTORS
Mr. Réjean Cantin
President, designated through co-optation
Mr. Denis Gagnon
Vice-President, appointed bv the Laval University executive committee
Mr. Michel Gervais
Secretary and General Director
Mr. Denis Bradet
Administrator, appointed by the Centre hospitalier Robert-Giffard Board of Directors
Mr. John Harbour
Mr. Guy Laberge
Ms. Sylvie Marcoux
Administrator, appointed bv the Laval University executive committee
Ms. Louise Milot
Ms. Lucille Morin
Administrator, designated through co-optation
Mr. Luc Trahan
Administrator, appointed bv the Laval University executive committee
Mr. Aubert Belzile
Invited Board Member
Ms. Hélène Bourque
Mr. Gérard Grégoire
Dr. Michel Maziade
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LIST OF RESEARCHERS
Cellular Neurobiology
Battaglia, Marco
Bureau, Alexandre
Chagnon, Yvon C.
Gingras, Nathalie
Labbe, Aurélie
Marino, Cecilia
Martinez, Maria
Maziade, Michel
Mérette, Chantal
Rouleau, Nancie
Roy, Marc-André
Bouchard, Roch-Hugo
Carrière, Monique
Clément, Michèle
Dallaire, Bernadette
Desmarais, Paul-André
Fossard, Marion
Gagnon, Pierre
Hébert, Marc
Hudon, Carol
Jackson, Philip
Jobin, Guy
Keating, Bernard
Ladouceur, Robert
Langlois, Frédéric
Lemelin, Sophie
Macoir, Joël
McCubbin, Michael
Monfette-Caron, Marie-Ève
Morasse, Karine
Morin, Charles M.
Pépin, Geneviève
Pourcher, Emmanuelle
Primeau, François
Provencher, Hélène
Provencher, Martin D.
Rousseau, François
Simard, Martine
Tremblay, Sébastien
Vallières, Annie
Villeneuve, Évens
Vincent, Annick
Vincent, Pierre
Evaluative and Clinical Research
Other
Aubé, Denise
Baruch, Philippe
Bastien, Célyne
Bégin, Catherine
Ben Amor, Leila
Bergeron-Leclerc, Christiane
Capaday, Charles
Côté, Daniel
De Koninck, Paul
De Koninck, Yves
Pellegrini, Luca
Saghatelyan, Armen
Sik, Attila
Toth, Katalin
Vallée, Réal
Zhang, Ji
Systemic Neurobiology
Amzica, Florin
Deschênes, Martin
Doré, François Y.
Goulet, Sonia
Gravel, Claude
Parent, André
Timofeev, Igor
Genetic Psychiatry
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For further details, consult Volume 2 at www.crulrg.ulaval.ca
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LIST OF STUDENTS ENROLLED IN GRADUATE STUDIES
Keller, Anne-Florence
Kovács, Krisztina
Kroeger, Daniel
Labelle, Marie-Hélène
Labrakakis, Charalampos
Labrecque, Simon
Lachance, Gaston
Lafortune, Frantz-Daniel
Lagrange, Véronique
Laroche, D.
Lavallée, Philippe
Lavertu, Guillaume
Lavertu, Jean-Michel
Lavoie, François
Lavoie, Marie-Pier
Lavoie, Nathalie
Lebel, Eric
Leblanc, Mélanie
LeChasseur, Yoan
Lefebvre, Andrée-Anne
Lehoux, Catherine
Lemasson, Morgane
Lemieux, Mado
Létourneau, Karine
Lévesque, Martin
L'Heureux, Nadia
Lorenzo, Louis-Étienne
Lucas, Michel
Marois, Marie-Josée
Marquis, Jean-Philippe
Massouh, Mireille
Melkonyan, Gurgen
Michea, Rodrigo
Moreau, Vincent
Morin, Marie-Hélène
Naud, Richard
Nita, Dragos
Ouellet, Marie-Christine
Ouellet, Rosalie
Pagès, Stéphane
Pâquet, Steve
Parent, Martin
Parys, Benjamin
Pelletier, Marie-France
Pelletier, Olivier
Picard, Marie-Ève
Plante, Julie
Pokidchenko, Tatiana
Potvin, Olivier
Poulin, Majorie
Proulx, Eliane
Raymond, Éric
Richard, Sandra
Rioux, Alain
Routhier, Marie-Ève
Roy, Hugo
Roy, Louis
Roy, Martin
Rubio Alvarez, Walter Rodolfo
Samoud, Mariem
Sanscartier, Annie
Sasseville, Alexandre
Schmouth, Marie-Ève
Schoonheere, Edwige
Seigneur, Josée
Shi, Xiang Qun
Simard, Catherine
Snapyan, Marina
St-Charles Bernier, Catherine
St-Jean, Geneviève
Tamburri, Albert David
Théberge, Isabelle
Thériault, Annie
Therriault-Proulx, François
Thibaudeau, Geneviève
Timofeeva, Elena
Tremblay, Annie
Turcotte, Isabelle
Urbain, Nadia
Vallières, Annie
Villeneuve, Lucie
Villeneuve, Sandra
Vinet, Jonathan
Wallman, Marie-Josée
Yu, Deli
Zomorrodi Moghadam, Reza
27/10/06
09:11
Page 23
Doucet, Patricia
Dragos, Nita
Drouin-Maziade, Christine
Duclos, Mélanie
Dufour, Hugues
Dufour, Julie
Dufour, Pascal
Dufour, Suzie
Dufresne, Caroline
Dufresne, Virginie
Echeverri Castano, Estefania
Elfassihi, Latifa
Elliott, Jimmy
Éthier, Christian
Ferecskó, Sándor Alex
Forest, Amélie
Fortier-Brochu, Émilie
Fraser, Alex
Furita, Takahiro
Gagné, Anne-Marie
Gagnon, Martin
Galarneau, Julie
Gaudreau, Jean-David
Gauthier, Caroline
Gauvin, Marie-Ève
Gendreau, François
Gendron, David
Gilbert, Elsa
Gilbert, Liça
Girard, Caroline
Giraud, Isabelle
Godin, Antoine
Grandmaison, Éric
Guay, Catherine
Guimond, Sandra
Hachey, Nicole
Heinze, Katrin
Hubert, Ulysse
Huot, Philippe
Jacques, Christian
Jean, Catherine
Jean, Léonie
Jeyaraju, Danny Vijey
Jomphe, Valérie
18
Adam-Côté, Hugo
Asselin, Geneviève
Audet, Marie-Claude
Avramescu, Sinziana
Baïda, Mohamed
Baillargeon, Mireille
Bandaru, Sirisha
Bastien-Dionne, Pierre-Olivier
Beaulieu-Bonneau, Simon
Bélanger, Érik
Bellemare, Sandra
Belleville, Geneviève
Bergeron, Amélie
Bergeron-Leclerc, Christiane
Billet, Claire
Blouin, Mélissa
Blouin-Thomassin, Karine
Bokor, Hajnalka
Bories, Cyril
Boucher, Jérôme
Boucher, Olivier
Boudreau, Dominic
Bourque, Hélène
Boutin, Julie
Brassard Lapointe, Marie-Laure
Brizzi, Laurent
Bussières, Ève-Line
Caenepeel, Didier
Cantinotti, Michael
Carmichaël, Pierre-Hugues
Caron, Anne
Castonguay, Annie
Cellard, Caroline
Chauvette, Sylvain
Chever, Oana
Cliche, Marie-Ève
Cordero-Erausquin, Matilde
Costantino, Santiago
Côté, Isabelle
Daley, Meagan
Davidson, Judith
Déry, Bernard
Dolique, Tiphaine
Doré, Marie-Claire
LIST OF STAFF
Tremblay, Claude
Trépanier, Johanne
Turmel, Jacqueline
Turner, Caroline
Vachon, François
Vachon, Pierre
Vallières, Chantal
Vandal, Karen
Viau-Guay, Laurence
Viger, Sylvie
Villeneuve, Julie
Wiederkehr, Sandra
19
09:11
Lehoux, Maripier
Lemieux, Philippe
Lévesque, Jessy
Liu, Hong
Lopez, Cedric
Lorrain, Ann
Maltais, Nicole
Marcaurelle, Hélène
Masar, Dominique
Maxes-Fournier, Catherine
Mimeault, Véronique
Mineau, Caroline
Nault, Francine
Packwood, Sonia
Paquet, Jean
Paradis, Mireille
Parent, Rémy
Patry, Simon
Payette, Marie-Claude
Pelletier, Sophie
Peralta, Modesto
Petit, Sonia
Plourde, Marilyn
Poirier, Claudie
Pourcher Bouchard, Jordi
Prescott, Steven
Prud'homme, Nicolas
René, Linda
Roy, France
Savard, Nathalie
Simard, Anne-Marie
Simard, Monique
Soucy, Nadia
St-Germain, Lise
Tanguay, Stéphane
Thériault, Chantal
Thériault, Francine
Thibault, Dany
27/10/06
Page 22
Diallo, Mamadou Saliou
Dolbec, Anne
Duchesne, Sara
Duguay, Johanne
Dumont, Frédéric
Dussault, Amélie
Émond, Claudia
Fecteau, Annie
Fournier, Alain
Frenette, Amélie
Ftomov, Sergiu
Gagnon, Lise
Gagnon, Lisette
Gagnon, Nadine
Gagnon, Solange
Gariepy, Karine
Gélinas, Marie-Louise
Giguère, Louise
Godard, Julie
Gravel, Lyne
Guérard, Katherine
Hamel, Monique
Hamelin, Johanne
Huang, Xiao Fang
Ivers, Hans
Jacques, Paul
Jobidon, Marie-Ève
Kenny, Chantal
Koubassov, Vladimir
Labbé, Annie
Lagrandeur, Julie
Lamarche, Julie
Lamothe, Hélène
Lamy, Manon
Lapointe, Claude
Laroche-Veilleux, Carine
Leblanc, Mélanie
Leclerc, Nicole
Alain, Mélanie
Bachand, Karine
Baida, Mohamed
Behna, Salma
Bélanger, Louise
Bellerose, Guylaine
Bergeron, René-Pierre
Berthelot, Nicolas
Billet, Claire
Blackburn, Céline
Blanchet, Guylaine
Blanchet, Josée
Blier, Mylène
Boivin, Denise
Boivin, Dominick
Boucher, Anne
Bourgon, Sonya
Bourque, Hélène
Boutin, Pierrette
Brassard, Andrée
Brassard, Marie-Laure
Bruneau Bhérer, Rosee
Cantin, Frédéric
Cayer, Marie-Hélène
Cayer, Mireille
Champoux, Sara
Chapdelaine, Denis
Charette, Guy
Charpenet, Gilles
Charron, Marie-Claude
Clermont, Mélissa
Cloutier, Ingrid
Côté, Amélie
Côté, Doris
Côté, Sylvain
Couture, Catherine
Croteau, Jordie
Demers, David
27/10/06
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COLLABORATIONS INTERNATIONALES
ALLEMAGNE/GERMANY
Bayerische Julius-Maximilians-Universität Würzburg
Georg-August-Eberhard University of Göttingen,
Göttingen
Eberhard Karls Universität Tübingen
University of Munich, Munich
University of Calgary, Calgary, AB
University of Manitoba, Winnipeg, MB
University of Ottawa, Ottawa, ON
University of Saskatchewan, Saskatoon, SK
University of Toronto, Toronto, ON
York University, Toronto, ON
AUSTRALIE/AUSTRALIA
ESPAGNE/SPAIN
University of Melbourne, Victoria
Victoria University, Melbourne
Universidad de Navarra, Navarra
BELGIQUE/BELGIUM
Albert Einstein College of Medicine, Bronx, NY
Columbia University, New York, NY
Biological Rhythms Research Laboratory, Chicago, IL
Indiana University, Bloomington, IN
Dartmouth-Hitchcock Medical Centre, Lebanon, NH
NCBI, NLM, National Institutes of Health, Bethesda, MD
Florida International University, Miami, FL
College of Health and Urban Affairs, Miami, FL
Dartmouth Psychiatric Research Center, Concord, NH
Harvard Medical School, Boston, MA
Oregon Health & Science University, Portland, OR
Université de Liège, Liège
Université libre de Bruxelles, Bruxelles
CANADA
20
Baycrest Centre for Geriatric Care
McMaster University, Hamilton, ON
Tom Baker Cancer Centre, Calgary, AB
Dalhousie University, Halifax, NS
University of Alberta, Edmonton, AB
University of British Columbia, Vancouver, BC
ÉTATS-UNIS/UNITED STATES
SRI International Human Sleep Research Program,
Menlo Park, CA
Louisiana State University, Baton Rouge, LA
Texas A & M University, College Station, TX
Thomas Jefferson University, Philadelphia, PA
UCSD School of Medicine, San Diego, CA
University of California, San Diego, CA
University of Iowa, Iowa City, IA
University of Minnesota, Minneapolis, MN
University of Pittsburgh, Pittsburgh, PA
University of Southern California, Los Angeles, CA
University of Wisconsin-Milwaukee, Milwaukee, WI
Washington University in St. Louis-School of Medicine,
St. Louis, MO
Wayne State University, Detroit, MI
Wright State University, Dayton, OH
Southwest Foundation for Biomedical Research,
San Antonio, TX
Medical College of Virginia, Richmond, VA
27/10/06
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Page 21
INTERNATIONAL COLLABORATORS
ITALIE/ITALY
University of Helsinki, Helsinki
University of Kuopio, Kuopio
University of Oulu, Oulu
Vita Salute San Raffaele University, Milan
SerT di Gallarate, ASL Varese
University of Bologna, Bologna
University of Genova, Genova
FRANCE
INSERM, Hôpital de la Salpêtrière, Paris
Molecular Engines Laboratories, Paris
UMR 7519 CNRS/ULP, Neurophysiologie cellulaire et
intégrée, Lyon
Université Louis Pasteur, Strasbourg
Université Paris VI, Paris
HONGRIE/HUNGARY
Institute of Experimental Medicine, Prague
National Institute of Neurosurgery, Budapest
Semmelweis University, Budapest
QUÉBEC
CHUM – Pavillon Hôtel-Dieu, Québec
Clinical Research Institute of Montreal, Montréal
Concordia University, Montréal
Hôpital du Sacré-Cœur de Montréal, Montréal
Institut universitaire de gériatrie de Montréal
Jewish General Hospital, Montréal
McGill University, Montréal
Montreal Neurological Institute, Montréal
Université du Québec à Montréal, Montréal
Université Laval, Québec
AMÉRIQUE DU SUD/SOUTH AMERICA
Instituto Venezolano de Investigaciones
Cientificas, Caracas, Venezuela
ROYAUME-UNI ET ÉCOSSE/UNITED
KINGDOM AND SCOTLAND
Cardiff University, Wales
Newcastle University, Newcastle
University of Glasgow, Glasgow
University of Plymouth, Plymouth
SUISSE/SWITZERLAND
Cytos Biotechnology AG / ETH Zurich,
University of Geneva, Genève
Wagistrasse 21, Zurich-Schlieren Switzerland
Hôpitaux universitaires de Genève, Genève
AUTRES/OTHERS
Agriculture and Agri-Food Canada, Edmonton, AB
AstraZeneca, Montréal, QC
Avantis Pharma, Vitry-sur-Seine, France
Bliss Murphy Cancer Centre, St. Johns, NF
CLSC-CHSLD Haute-Ville-des-Rivières, Québec, QC
Mayo Clinic, Rochester, MN
Palliative Care Research Initiative, Edmonton, AB
RRSSS03, Québec, QC
21
Photo : Frédéric Cantin
FINLANDE/FINLAND

Volume 1 - Centre de recherche Institut universitaire en santé

Transcription

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