2015 Annual Report - UTSA Neurosciences Institute

NEUROSCIENCES INSTITUTE ANNUAL REPORT CALENDAR YEAR 2015
U T SA
N eu r o s c i e nces Institute
Annual Report
UTSA Neuroscience 2015
Administration
As of 2015 we were 23 faculty and 7
post-docs from 7 departments across 6
colleges.
DIRECTOR
Charles J. Wilson PhD
Ewing Halsell Chair of Biology
Reports to George Perry PhD
College of Science
Campus Address
BSB 1.03.14
charles.wilson@utsa.edu
tel: 210.458.5658
fax: 210.458.7491
Research Website:
http://marlin.life.utsa.edu
Institute Website:
http://neuroscience.utsa.edu
Institute inception year: 2008
Current reporting period:
Fiscal Data follows FY 2015
reporting period calendar 2015
Goals
The Institute’s most vital and
comprehensive goal is to promote
excellence in our research-active
neuroscience community. To this end, our
program is designed to:
•Enhance the Research Environment
for Neuroscientists at UTSA by
sponsoring research seminars and
symposia, and by building and
maintaining research core facilities as
well as supporting training and
education.
•Promote the Careers of UTSA
Neuroscientists in all Colleges and
Departments by organizing peer
mentoring, and other communitybuilding activities.
•Enhance the Intellectual
Environment at UTSA and in the San
Antonio community with public
Neuroscience educational events.
•Promote Collaborative Neuroscience
as a means to build innovative,
multidisciplinary research programs.
Our goals for research align with and
expand upon those of UTSA by
emphasizing the reality that our faculty
must compete and excel in a larger
context than the institution alone; we
focus on promoting the careers and
developing the national scientific stature of
our faculty as the single most effective
means to research excellence for the
institution.
Research Environment
Neuroscience Symposium.
The 2015 symposium on Cortical
Excitation was hosted by Alfonso
Apicella this year on November 4. It
featured 4 acclaimed researchers alongside
the host, sharing a day’s worth of research
talks on the factors that sculpt sensory
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
circuit information processing in the
neocortex. On the panel were: Dan
Feldman (Berkeley); Raju Metherate
(Irvine); Massimo Scanziani (UCSD); and Li
Zhang (USC). The symposium was
attended by over 80 researchers, fellows,
and students from various departments at
UTSA and UTHSCSA.
Neurobiology Seminars.
We value the Biology Department’s
Neurobiology Seminar Series as the
most important regular component of our
research environment. To lend our
support and ease some of the financial
burden on the Department, in 2015 we
supported 2 seminars (box, p 2).
Shared Instrumentation Cores.
The Institute is building research
capacity through support of two shared
instrumentation facilities: the OptoExcitability Core, and the 2-Photon
Microscopy Lab. Both are available for
use by Neuroscience researchers at UTSA.
The Opto-Excitability core serves
investigators requiring fabrication and/or
live animal implantation of optrodes or
chronic multi-channel electrodes for
neuroscience research applications. It was
established in 2010 via funding from the
San Antonio Life Sciences Institute
Neuroscience Infrastructure program. In
September 2011 it was transferred to the
Neurosciences Institute, where we
extended its scope to support the
development of in vivo optogenetic viral
injections. The core is under the direction
of Carlos Paladini.
The 2-Photon Microscopy Lab is
comprised of two multi-photon imaging
systems fully equipped for in vitro
electrophysiology and live tissue imaging.
Initially erected by the NIH/NCRR RCMI
grant, as of 2012 the core became fully
supported and maintained by the
Neurosciences Institute, under the
direction of Fidel Santamaria.
http://neuroscience.utsa.edu
NEUROSCIENCES INSTITUTE ANNUAL REPORT 2015
Cortical Circuit Symposium 11.4.15
Career Mentoring
One of the flagship initiatives of the
Neurosciences Institute has been our
program of weekly research &
mentorship meetings. They began as
a program development exercise in 2005
to build the 2007-2012 NINDS
Specialized Neuroscience Research
Program, but now extend well beyond the
scope of that program and serve as a
weekly 2-hour rotating forum to support
all level of trainees and faculty in their
grant development, manuscript
preparation, and career development.
Environment & Outreach
Public Outreach Lecture.
Our push toward neuroscience
awareness and education on campus and
in the community involves branding UTSA
as the major repository for brain science
in San Antonio. The centerpiece of this
effort is our annual Distinguished
Neuroscience Lecture for the
Public. The format is an evening lecture
by a luminary in the field, whose scientific
research and charismatic delivery
underscore to educated and inquisitive
San Antonians that Neuroscience
research holds the key to discovering our
human capacities and who we are.
Last Fall’s lecture featured renowned
developmental neurobiologist, Fred
(Rusty) Gage, (Salk Institute). Dr. Gage’s
talk, Neuronal Plasticity and Genomic
Diversity, described the genetic factors
governing cellular-level adaptability in the
CNS. The lecture was held in the UC
Ballroom on November 10th, and was
attended by 200 undergraduates,
researchers and members of the public.
The UTSA Neuroscientists Talk Shop Podcast
The Institute continues to build online
multimedia content by adding to its
Neurobiology Podcast series,
Neuroscientists Talk Shop. The series
features prominent external
Neuroscientists in scholarly yet accessible
discussion with a group of core UTSA
Neurobiologists. Discussions emphasize
the history and the process behind the
research. They are also a forum for
speculation and critical analysis in the
language that researchers naturally use.
Graduate students, venture capitalists,
engineers and enthusiasts from around
the world are among the listeners. In
2015, 21 new episodes were posted and
are available at the iTunes Music Store,
bringing the total number of episodes to
145 at the close of 2015. See box, p. 9.
Undergraduate Research.
The Institute is assisting in
undergraduate recruitment by building
web resources featuring academic and
research guidance and by hosting a mixer
for undergraduate neuro students to
network with our faculty. Institute
leadership has also met regularly with
interested students to help advise directly
and personally. Rapidly growing demand
for undergraduate Neuroscience research
opportunities has led us to secure some
generous funding from the Mind
Science Foundation to support a pair
of summer undergraduate research
interns for a 6-8 week full-time research
experience. In Summer 2015, two UTSA
undergraduates, Merridee Lefner and Kael
McInnis, served as Mind Science Fellows
in the Wanat and Jaffe labs, respectively.
Collaborations
Public Outreach Lecture.
Our Investigators are engaged in 6
funded multi-institution collaborations:
One is funded by a multi-PI NIH R01
grant (with Emory), one an NIH-funded
Morris K. Udall Center project (with
Northwestern University), one by an NSF
Collaborative grant with UTHSCSA, one
by a UT Brain Initiative grant with
UTHSCSA, and finally, an NSF multinational grant with the German Ministry
of Education and Research. Two others
are pending (Max Plank Institute in
Germany and one with the Hebrew
University in Jerusalem).
Internal collaborations are widespread
in our group. Currently, one multiinvestigator grant within our group is
funded (NSF Brain Initiative; Drs.
Santamaria, Troyer and Wicha). Members
of our faculty routinely publish
collaborative papers within and across
institutions; in the current list of 2015
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
2015 EVENTS
NEURO LECTURES
Russel Reiter PhD
Professor
Cellular & Structural Biology
UT Health Sci Ctr San Antonio
This is your brain, this is your brain on
melatonin 01.22.15
Anthony Grace PhD
Professor of Neurology
University of Pittsburgh
Ventral Hippocampal/Amygdala Regulation
of the VTA Dopamine System and its Role
in Schizophrenia and Depression
02.26.15
SYMPOSIUM
Cortical Excitation, 11.04.15
Alfonso Apicella (UTSA), Dan Feldman
(Berkeley), Raju Metherate (Irvine),
Massimo Scanziani (UCSD), Li Zhang
(USC).
PUBLIC LECTURE
Fred Gage (Salk Institute),
11.10.15
Neuronal Plasticity and Genomic
Diversity.
Fred Gage Distinguished Lecture 11.4.15
http://neuroscience.utsa.edu
NEUROSCIENCES INSTITUTE ANNUAL REPORT publications, nearly all of them arose from collaborations of groups
within UTSA, or multi-institutional studies. These reflect research
performed with numerous domestic and international researchers at
top tier institutions (e.g., UT Austin, MIT, Universidad de Jaén,
Vanderbilt, University of Nebraska, Texas A&M, Case Western,
University of Puerto Rico, etc), as well as with other faculty across
departments at UTSA.
People
2015
FY2015 NIH AWARDS
* New awards
R01NS072458 PI: Gaufo, GO
Morphogen-dependent Regulation of Motor Neurogenesis
along the A/P Axis $321,563
R01DA030530 PI: Paladini, Carlos A
The synaptic origin of reward prediction error signal in
dopaminergic neurons $276,482
Welcome to Isabel Muzzio, who joined our ranks as Associate
Professor this past summer. Congratulations and good luck to
Denard Simmons on his successful dissertation defense this year.
* R01DA038453 co-PI: Paladini, Carlos A
Mentoring Data
Cellular Mechanisms of cocaine neuron bursting $365,150
A census of the trainees reported to be working in Neuroscience
Institute Labs during 2015 is given below. This is a partial list, that
includes only those students that were reported to, or interacted
directly with Institute administration.
R00DA033386 PI: Wanat, Matthew J
CRF and Stress Modulation of Phasic Dopamine Release and
Behavior $239,815
29 undergraduates (reflecting Bio, Psych, Comp Sci majors & 2
community college students)
❖ 26 MS/PHD students (5 MS, 21 PhD; Programs represented are
Biology, Statistics, Psychology, Biomedical Engineering and 1 German
collaboration student);
❖ 7 Post doctoral Fellows (6 UTSA & 1 visiting post-doc from
Germany).
❖
The Year in Numbers
For Calendar year 2015:
❖ 21 proposals were submitted, 14 to federal agencies;
❖ 9 new awards were received (asterisks, right panel);
❖ 21 awards (new and continuing) were administered by the
Institute; the 18 awards at right, and an additional 3 in no costextension (not shown);
❖ $2,436,362* was the total dollar value of award income;
❖ $1,983,0201 was the total dollar value of research expenditures
*Award Income computed by summing awards enumerated in right panel
(all NIH + new NSF + new non-federal)
1Total research expenditures provided by Grants & Contracts for FY2015
Research Impact
Scholarly Output
Institute faculty generated at least 60 publications in 2015 (see
Investigators in Press). These include peer reviewed journal
articles, invited reviews, and book chapters. On a multimedia note, the
Institute generated 18 research themed podcasts as part of our
Neuroscientists Talk Shop series. For the list of titles featuring guest
speakers, see box, p7.
New Grants and Submissions
Kudos to the faculty who submitted research grants through the
Institute this year (Apicella, Jaffe, Muzzio, Paladini, Santamaria, Wanat,
Wicha, Wilson) and especially to the students who submitted PhD
training grants in 2015 (Rock, Gomez).
Congratulations to everyone with new Federal awards in 2015:
David Jaffe (NSF), Carlos Paladini (2 R01s), Nicole Wicha (R21) and an
unofficial advance WOOT to Jorge for his 2016 F31!
Finally, congratulations also to all who secured funding from
foundations and other internal or external sources: David Jaffe, Carlos
Paladini, and Charles Wilson.
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
Mechanisms of cocaine hypersensitivity following chronic DBH
inhibition $183,696
* R01MH1072293 PI: Paladini, Carlos A
*R21HD0079884 PI: Wicha, Nicole Y
Brain and behavior of multiplication fact learning in bilingual
children $208,750
P50NS047085 PI: Wilson, Charles J
Rhythmicity and Synchrony in the Basal Ganglia $254,201
R01NS072197 PI: Wilson, Charles J
A Tonically Active Network in the Neostriatum $284,484
FY2015 NSF AWARDS
Award totals
EF 1137897 PI: Santamaria, Fidel
Analyzing Neuronal Activity When Classical Reaction-Diffusion
Breaks Down $608,000
IOS 1208029 PI: Santamaria, Fidel
US-German Collaboration:The effects of chloride dynamics in
cerebellar computation dynamics in cerebellar computation
$550,104
IOS 1516648 PI: Santamaria, Fidel BRAIN Inititative
Awardees Meeting in Bethesda $41,490
DBI 1451032 Co-Is: Santamaria,Troyer,Wicha BRAIN EAGER:
Analyzing and Modeling Power-Law Behaviors in Neuroscience
$300,000
*IOS 1456862 Co-PI: Jaffe. Understanding How BK
Potassium Channels Enhance a Neuron's Input/Output
Function. $52,479
FY2015 NON FEDERAL AWARDS
Mind Science Foundation Summer Undergraduate Internship
Award $5,000
*UTSA VPR GREAT award. PI: Jaffe. Intensified
hippocampal circuits contributing to the symptoms of
posttraumatic stress disorder $20,000
*San Antonio Area Foundation, PI: Jaffe. Cellular
mechanisms underlying pain relief by dorsal root ganglion
stimulation in an animal model of diabetic neuropathy
$27,290
*UT BRAIN Initiative. PI: Paladini. Advanced Stimulation
Therapeutics for Parkinson's Disease $42,452
*Stevens Charitable Foundation. PI: Wilson. Advanced
Stimulation Therapeutics for Parkinson's Disease $160k in
2015, (360k total)
http://neuroscience.utsa.edu
NEUROSCIENCES INSTITUTE ANNUAL REPORT 2015
2015 NTS PODCASTS
Submission/Award Data FY2010-15
Neuroscientists Talk Shop is the University of
Texas at San Antonio's Neurobiology Podcast,
which showcases the current research of
internationally renowned guest Neuroscientists. Each episode
features a moderated discussion with a cross section of UTSA
Neurobiology faculty, highlighting the featured guest's
research, and the state of the art in the field at hand. The
following episodes were added in 2015:
4
3.54
$ millions
3
2.51
2
1
0
2.71 2.78
3.23
2.36
1.98
1.03
2008 2009 2010 2011 2012 2013 2014 2015
Institute Expenditures since inception, in $millions. Dollar
amounts indicate expenses from federal grant accounts (Source, UTSA
VPR/Grants & Accounting).
4
$ millions
3
3.59
3.58
2.99
2.44
2
1
0
1.31
2010
2011
2012
2013
1.67
2014
2015
Institute award income 2010-15, in $millions. Dollar
amounts indicate total costs awarded to UTSA (Source, 2010-2014
VPR; 2015 computed from NIH, NSF and UTSA OSP award data.).
#125 Stephanie
Borgland (U of Calgary)
#126 Heather Read (U Conn)
#127 Carmen Canavier (LSU)
#128 Anthony Grace (U of Pitt Sch of Med)
#129 Anatol Kreizer (UCSF)
#130 Hyoung-gon Lee (Case Western)
#131 Sarah Laszlo (Binghamton)
#132 Bharath Chandrasekaran (UT Austin)
#133 Michael Long (NYU Med)
#134 James Shine (Stanford)
#135 Kres̆imir Josić (U of Houston)
#136 David Morilak (UTHSCSA)
#137 Rodrigo Espana (Drexel)
#138 Mounya Elhilali (Johns Hopkins)
#139 Paul Kulesa (Stowers Institute)
#140 Craig Atwood (U of Wisconsin)
#141 Sensory Cortex Microcircuit Symposium
#142 Mimi Kao (Tufts)
#143 Rusty Gage (Salk Inst. UCSD)
#144 Robert Stackman (Salk Inst. UCSD)
#145 Patrick Sheets (Salk Inst. UCSD)
acknowledgement: JM Tepper for original music.
Main Site: http://snrp.utsa.edu/Podcast/Podcast.html
iTunes Preview:
https://itunes.apple.com/us/podcast/neuroscientists-talkshop/id279181187
UNDERGRADUATE RESEARCHERS 2015
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4.
5.
6.
7.
8.
9.
Megan Aumann, Biology
Joseph Blessing, Biology
Zeliene Brown, Biology
Joseph Casto, Honors Biology
Brenda Diaz, LSAMP summer
student, now at SAC
Jocelyn Carnicle, Honors Biology
Ricardo Castañeda, Honors
Psychology Chelsea Cuevas, NW Vista (Biology
Associates) Steven Evans, Honors Computer
Science 10. Robert Graham, Biology
11. Amandine Grenier, BA Biology
12. Omar Gonzalez LSAMP summer
student
13. James Gutierrez, Biology
14. Graham Haug, Philosophy
15. Merridee Lefner, Biology
16. Katherine Madrid, Psychology
17. Brandon Mikneus, Honors Computer
Science
18. Kael McInnis, Biology
19. Chad Milam, Honors Biology
20. Jacob Momsen, Biology
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
21.
22.
23.
24.
25.
26.
27.
28.
29.
Jacques Onu, Biology
Jessica Perkins, Biology
Andres Ruiz, Honors Biology
Yvonne Schulz, Biology
Scott Treadwell, Biology
Omar Thannoun,post-bac
Carmen Varela, Biology
Helen Vogt, Biology
Van Heye, Palo Alto Comm College
http://neuroscience.utsa.edu
NEUROSCIENCES INSTITUTE ANNUAL REPORT 2015
Investigators in Press
Publications1 2015
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Rock C, Apicella AJ. Callosal projections drive neuronalspecific responses in the mouse auditory cortex. J Neurosci.
2015 Apr 29;35(17):6703-13.
Wang X, Xu H, Huang Y, Gu S, Jiang JX. Coupling Effect of
Water and Proteoglycans on the In Situ Toughness of Bone. J
Bone Miner Res. 2015 Dec 28.
Ruan J, Jin V, Huang Y, Xu H, Edwards JS, Chen Y, Zhao Z.
Education, collaboration and innovation: Intelligent biology
and medicine in the era of big data. BMC Genomics 2015
11;16 Suppl 7:S1. Epub 2015 Jun 11.
Chen HI, Liu Y, Zou Y, Lai Z, Sarkar D, Huang Y, Chen Y.
Differential expression analysis of RNA sequencing data by
incorporating non-exonic mapped reads.BMC Genomics
2015 11;16 Suppl 7:S14. Epub 2015 Jun 11.
Cui X, Meng J, Rao MK, Chen Y, Huang Y HEPeak: an
HMM-based exome peak-finding package for RNA
epigenome sequencing data. BMC Genomics 2015 21;16
Suppl 4:S2. Epub 2015 Apr 21.
Zhou Y, Chen HI, Lin AL, Dang H, Haack K, Cole SA, Huang
Y, Yu H, Chen Y,Yeh CK. Early gene expression in salivary
gland after isoproterenol treatment. J Cell Biochem. 2015
Mar;116(3):431-7. PubMed PMID: 25336019
Liu L, Zhang SW, Zhang YC, Liu H, Zhang L, Chen R, Huang
Y, Meng J. Decomposition of RNA methylome reveals comethylation patterns induced by latent enzymatic regulators
of the epitranscriptome. Mol Biosyst. 2015 Jan;11(1):262-74.
Mao Z, Ma C, Huang TH, Chen Y, Huang Y. BIMMER: a
novel algorithm for detecting differential DNA methylation
regions from MBDCap-seq data. BMC Bioinformatics.
2014;15 Suppl 12:S6. doi: 10.1186/1471-2105-15-S12-S6.
Epub 2014 Nov 6.
Liu H, Flores MA, Meng J, Zhang L, Zhao X, Rao MK, Chen Y,
Huang Y. MeT-DB: a database of transcriptome
methylation in mammalian cells. Nucleic Acids Res. 2015 Jan;
43(Database issue):D197-203. Epub 2014 Nov 6.
Meng J, Lu Z, Liu H, Zhang L, Zhang S, Chen Y, Rao MK,
Huang Y. A protocol for RNA methylation differential
analysis with MeRIP-Seq data and exomePeak R/
Bioconductor package. Methods. 2014 Oct 1;69(3):274-81.
Epub 2014 Jun 27.
Sundt D, Gamper N, Jaffe DB. Spike propagation through
the dorsal root ganglia in an unmyelinated sensory neuron: a
modeling study. J Neurophysiol. 2015 Sep 2:jn.00226.2015.
Hermann BP, Mutoji KN,Velte EK, Ko D, Oatley JM, Geyer
CB, McCarrey JR. Transcriptional and translational
heterogeneity among neonatal mouse spermatogonia. Biol
Reprod. 2015 Feb;92(2):54. PMCID: PMC4342790.
Yuan RK, Hebert JC, Thomas AS, Wann EG, Muzzio IA.
HDAC I inhibition in the dorsal and ventral hippocampus
differentially modulates predator-odor fear learning and
generalization Front Neurosci. 2015 Sep 22;9:319. PMCID:
PMC4585269.
Wang ME,Yuan RK, Keinath AT, Ramos Álvarez MM,
Muzzio IA. Extinction of Learned Fear Induces
Hippocampal Place Cell Remapping. J Neurosci. 2015 Jun
17;35(24):9122-36. PMCID: PMC4469738.
1 Citations
15. Julian JB, Keinath AT, Muzzio IA, Epstein RA. Place
recognition and heading retrieval are mediated by
dissociable cognitive systems in mice. Proc Natl Acad Sci U S
A. 2015 May 19;112(20):6503-8. PMCID: PMC4443371.
16. Keinath AT, Wang ME, Wann EG,Yuan RK, Dudman JT,
Muzzio IA. Precise spatial coding is preserved along the
longitudinal hippocampal axis. Hippocampus. 2014 Dec;
24(12):1533-48. PMCID: PMC4447627.
17. Gaval-Cruz M, Goertz RB, Puttick DJ, Bowles DE, Meyer
RC, Hall RA, Ko D, Paladini CA, Weinshenker D. Chronic
loss of noradrenergic tone produces beta-arrestin2mediated cocaine hypersensitivity and alters cellular D2
responses in the nucleus accumbens. Addict Biol. 2016 Jan;
21(1):35-48.
18. Goertz RB, Wanat MJ, Gomez JA, Brown ZJ, Phillips PE,
Paladini CA. Cocaine increases dopaminergic neuron and
motor activity via midbrain α1 adrenergic signaling.
Neuropsychopharmacology. 2015 Mar 13;40(5):1151-62.
PMCID: PMC4367457.
19. Rodrigues R, Petersen RB, Perry G. Synergy between
depression and Alzheimer’s disease: a spectrum model of
genomic vulnerability with therapeutic implications.
Integrative Mol Med 2:139-141, 2015.
20. Rodrigues R, Perry G, Petersen R. Basis and argument into
the work “parallels on depression and Alzheimer’s disease
and different genomic vulnerability leading to therapeutic
utilities”. Int J Neurol Neurother 2:1, 2015.
21. Singh SK, Srikrishna S, Castellani RJ, Perry G. Antioxidants
in the prevention and treatment of Alzheimer’s disease. In:
Nutritional Antioxidant Therapies: treatments and
perspectives, Part 3: Nutritional antioxidants in health and
disease. (in print), 2015.
22. Luna-Muñoz J, Perry G, Guevara J. Obituary: Raúl Mena:
1953-2014. J Alzheimer Dis 45:325-327, 2015.
23. Wang X, Wang W, Li L, Perry G, Lee H-g, Zhu X. Oxidative
stress and mitochondrial dysfunction in Alzheimer’s disease.
Biochim Biophys Acta, 1842:1240-1247, 2014.
24. Castellani RJ, Peclovits A, Perry G. Neuropathology of
Alzheimer’s disease. In: Pathobiology of Human Disease,
McManus LM, Mitchell RN, Eds, Elsevier, Oxford, United
Kingdom, 2014, pp 2014-2020.
25. Castellani RJ, Perry G, Iverson GL. Chronic effects of mild
neurotrauma: putting the cart before the horse? J
Neuropathol Exp Neurol 74:493-499, 2015.
26. Forero DA,Vélez-van-Meerbeke A, Deshpande SN, Nicolini
H, Perry G. Neuropsychiatric genetics in developing
countries: current challenges, World J Psychiatry 4:69-71,
2014.
27. Zhang F, Wang W, Siedlak SL, Liu Y, Liu J, Jiang K, Perry G,
Zhu X, Wang X. Miro1 deficiency in amyotrophic lateral
sclerosis. Frontiers in Aging Neurosci 7:8 pages, doi:
10.3389/fnagi.2015.00100, 2015.
28. Bajic V, Stanojevic B, Zivkovic L, Cabarkapa A, Perry G,
Arendt T, Spremo-Potparevic B. Cyclin dependent Kinase
11, neuroinflammation and Alzheimer’s disease: a review. J
Clin Cell Immunol 6:2, 2015. (March 2015)
presented alphabetically by Institute Investigator.
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
http://neuroscience.utsa.edu
NEUROSCIENCES INSTITUTE ANNUAL REPORT 29. Perry G, Dixson M. Understanding Impact Factors, 2015.
http://www.slideshare.net/GeorgePerry3/research-impactfactors
30. Perry G. Lifelong Mentorship, 2015. http://
www.slideshare.net/GeorgePerry3/lifelong-mentorshiploma-linda-university.
31. Perry G. Medical Education In the Wired Age, 2015. http://
www.slideshare.net/GeorgePerry3/medical-education-in-thewired-age.
32. Perry G. Editorial: Two hundred treasured issues! J
Alzheimer Dis 44:725, 2015.
33. Perry G. Meet our editorial board member. Mini Rev Med
Chem 15:719, 2015.
34. Perry G. Meet the editorial board. Curr Protein Peptide
Sci 16:181, 2015.
35. Zivkovic L, Bajic V, Perry G, Spremo-Potparevica B.
Alterations of the X Chromosome in Lymphocytes of
Alzheimer's Disease Patients. Curr Alzheimer Res. 2015 Oct
27.
36. Calderón-Garcidueñas L, Franco-Lira M, D'Angiulli A,
Rodríguez-Díaz J, Blaurock-Busch E, Busch Y, Chao CK,
Thompson C, Mukherjee PS, Torres-Jardón R, Perry G.
Mexico City normal weight children exposed to high
concentrations of ambient PM2.5 show high blood leptin
and endothelin-1, vitamin D deficiency, and food reward
hormone dysregulation versus low pollution controls.
Relevance for obesity and Alzheimer disease. Environ Res.
2015 Jul;140:579-92.
37. Zhang F, Su B, Wang C, Siedlak SL, Mondragon-Rodriguez S,
Lee HG, Wang X, Perry G, Zhu X. Posttranslational
modifications of α-tubulin in alzheimer disease. Transl
Neurodegener. 2015 May 15;4:9. PMCID: PMC4448339.
38. Avila J, Perry G, Strange BA, Hernandez F. Alternative
neural circuitry that might be impaired in the development
of Alzheimer disease. Front Neurosci. 2015 Apr 23;9:145.
Review. PMCID: PMC4407584.
39. Gerenu G, Liu K, Chojnacki JE, Saathoff JM, Martínez-Martín
P, Perry G, Zhu X, Lee HG, Zhang S. Curcumin/melatonin
hybrid 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5methoxy-1H-indol-3-yl)-ethyl]-amide ameliorates AD-like
pathology in the APP/PS1 mouse model. ACS Chem
Neurosci. 2015 Aug 19;6(8):1393-9.
40. Perry G. Two hundred treasured issues! J Alzheimers Dis.
2015;44(3):725. Fornicola W, Pelcovits A, Li BX, Heath J,
Perry G, Castellani RJ. Alzheimer Disease Pathology in
Middle Age Reveals a Spatial-Temporal Disconnect Between
Amyloid-β and Phosphorylated Tau. Open Neurol J. 2014
Dec 12;8:22-6.
41. Fawver JN, Ghiwot Y, Koola C, Carrera W, Rodriguez-Rivera
J, Hernandez C, Dineley KT, Kong Y, Li J, Jhamandas J, Perry
G, Murray IV. Islet amyloid polypeptide (IAPP): a second
amyloid in Alzheimer's disease. Curr Alzheimer Res.
2014;11(10):928-40.
42. Bowen RL, Perry G, Xiong C, Smith MA, Atwood CS. A
clinical study of lupron depot in the treatment of women
with Alzheimer's disease: preservation of cognitive function
in patients taking an acetylcholinesterase inhibitor and
treated with high dose lupron over 48 weeks. J Alzheimers
Dis. 2015;44(2):549-60.
1 Citations
2015
43. Rodrigues R, Petersen RB, Perry G. Parallels between
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presented alphabetically by Institute Investigator.
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
http://neuroscience.utsa.edu