2014 Annual Report - UTSA Neurosciences Institute

ANNUAL REPORT Nº6
2014
UT SA
Ne u r o s c i e nces Institute
Annual Report
UTSA Neuroscience 2014
DIRECTOR
Charles J. Wilson PhD
Ewing Halsell Chair of Biology
Reports to George Perry PhD
College of Science
Campus Address
BSB 1.03.14
charles.wilson@utsa.edu
tel: 210.458.5658
fax: 210.458.7491
Research Website:
http://marlin.life.utsa.edu
Institute Website:
http://neuroscience.utsa.edu
Institute inception year: 2008
Current reporting period:
Fiscal Data follows FY 2013
9.1.2013- 8.31.2014
Publications and other events cover
1.1.14-12.31.14
People
Faculty Kudos
The Director of the UTSA
Neurosciences Institute is Charles
Wilson, who is the Ewing Halsell Chair of
Biology. Salma Quraishi serves daily
operations as Associate Director, and
Gregory Granados (Administrative
Associate II) manages fiscal operations.
Our 2014 Research Investigator roster was
comprised of 22 faculty and 7 postdocs from 6 departments across 6
colleges. See Appendix for affiliations.
Congratulations to Institute Investigator
Nicole Wicha for being awarded tenure
and promotion to the rank of Associate
Professor this year.
New Faculty
Welcome (officially this time) to new
Neurobiology faculty Matt Wanat, who
arrived this past April. Matt’s lab is off to a
solid start, complete with postdoc and
masters student, he has already submitted
his first NIH grant, and has a 2015 cover
article in press (BOOM!).
This year we welcome two new
Research Professors to our group; Matt
Higgs and Gerard Beaudoin. Matt
joins the Wilson Lab from Bill Spain’s group
at the University of Washington, and
Gerard is a veteran of the Paladini lab,
where he has been a postdoc for the past
3 years.
PhD Prog ram News
Congratulations to Doug Grow, for
successfully defending his dissertation in
2014: Doug is the 58th PhD graduate of
our PhD program.
This year 3 PhD students advanced to
candidacy: Emmanuel Michaelides,
Jorge Gomez, and Clinton Taylor.
Kudos to Soomin Song for winning the
best Neuroscience Poster (and an Ipad
mini!) at the COS Research Conference in
September.
Once again, the Institute would like to
recognize and laud the students who have
taken the initiative to submit federal grant
proposals this year: Soomin Song,
Alyssa Petko, Denard Simmons and
Crystal Rock. This is an important step
in preparation for your scientific careers.
Welcome also to our new crop of first
years, Juan Morales, Monique
Villareal, Alyssa Petko, and Crystal
Rock.
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
Congratulations also to the Dean of the
College of Sciences, George Perry for
being named to the Semmes Foundation
Distinguished Chair in Neurobiology.
Fiscal Snapshot
This fiscal year Institute Investigators
pulled a total of $1.67 million in award
income in the form of new and continuing
awards (see box, p 3). Institute labs posted
$2.01 million in research expenditures for
FY14. Our group members submitted 18
federal grant proposals in 2014, a number
of which have earned excellent priority
scores and are expected to be funded in
2015. To see how these numbers rack up
with historical data, see the Appendix.
Oversight
Steering committee & Advisors
Our Steering committee is comprised of
Investigators who carry current federal
funding that they chose to sponsor
through the institute. Our current voting
members are Gary Gaufo, Carlos Paladini,
Fidel Santamaria, Kelly Suter,Todd Troyer, Matt
Wanat, and Charles Wilson. New
Investigators are added as their Notices of
Awards come in and accounts are set up
under our fiscal structure.
We again thank our esteemed Advisors,
Dan Johnston, James Roberts, and David Weiss
for their continued availability and support
of our research mission since 2008.
Students and new faculty, get to know our
Advisors and introduce yourself, if you
haven’t already.
✧ Dan Johnston PhD, Professor &
Director, Center for Learning & Memory,
UT Austin.
✧ James Roberts PhD, Ruth C. & Andrew
G. Cowles Professor of Life Sciences, Trinity
University.
✧ David Weiss PhD, Professor &
Director, Department of Physiology,
UTHSCSA.
http://neuroscience.utsa.edu
ANNUAL REPORT Nº6
2014
Richard Palmiter Public Lecture
Environment
Neuroscience Symposium.
The 2014 symposium on Neuron
Regeneration was hosted by Annie
Lin this year, who decide to revamp the
usual format by expanding it to
incorporate the Cell & Molecular Biology
Program. She took the initiative of raising
funds from corporate sponsors to double
the usual panel of speakers and turn it
into a 2-day symposium. The CMB
program co-contributed support, making
this the first joint research event between
our two groups. The symposium was held
on October 27 & 28, and featured 8
acclaimed researchers sharing their work
on the factors that mediate cell fate and
neurogenic capacity in the CNS. On the
panel were: Bruce Appel (U of CO
Denver), Phil Horner (U of WA Med
Ctr), Jenny Hsieh (UT Southwestern),
Tony Koleske (Yale), Arnold Kriegstein
(UCSF),Vance Lemmon (U of Miami) and
Bettina Winckler (U of VA). Speaking
among them was the symposium’s host
and organizer, Institute Investigator Annie
Lin. The symposium was attended by
over 80 researchers, fellows, and students
from various departments at UTSA, UT
Austin and the University of Houston.
Public Outreach Lecture.
Shortly after Annie Lin orchestrated
the Institute’s bulked up 2014
symposium, she also organized our annual
Distinguished Lecture for the
Public by hosting HHMI Investigator and
pioneer of transgenic mouse models,
Richard Palmiter (U of WA School of
Medicine). Dr. Palmiter’s talk, The Neural
Circuits of Aversion: Learning to avoid bad
situations, described how molecular
genetic tools are being used to make
precise and reliable functional maps of the
neural circuits that guide high-level
organismic behavior. The lecture was held
in the UC Ballroom on November 10th,
and was attended by 200 undergraduates,
researchers and members of the public.
Neurobiology Seminars.
We value the Biology Department’s
Neurobiology Seminar Series as
perhaps the most vitally important regular
component of our research environment.
In order to lend our support and ease
some of the financial burden on the
department, the Institute annually
supports 4-8 speaker travel and
honoraria. In 2014 we supported 4
seminars, listed in the box, at right.
Shared Instrumentation Cores.
The Institute is building research
capacity through support of two shared
instrumentation facilities: the
Optogenetics Core, and the 2Photon Microscopy Lab. Both are
available for use by Neuroscience
researchers at UTSA.
The Optogenetics Core is open to
Investigators requiring fabrication and/or
live animal implantation of optrodes or
chronic multi-channel electrodes for
neuroscience research applications. It
was established in 2010 via funding from
the San Antonio Life Sciences Institute
Neuroscience Infrastructure program. In
September 2011 it was transferred to the
Neurosciences Institute, where we
extended its scope to support the
development of in vivo optogenetic viral
injections. The core is under the
direction of Carlos Paladini.
The 2-Photon Microscopy Lab is
comprised of two multi-photon imaging
systems fully equipped for in vitro
electrophysiology and live tissue imaging.
Initially erected by the NIH/NCRR RCMI
grant, as of 2012 the core became fully
supported and maintained by the
Neurosciences Institute, and is under the
direction of Fidel Santamaria.
Friday Research Sessions.
One of the flagship initiatives of the
Neurosciences Institute has been our
program of weekly research &
mentorship meetings. They began as
a program development exercise in 2005
to build the NINDS Specialized
Neuroscience Research Program, and so
became known as “SNRP Fridays.”
Now they extend well beyond the scope
of that program and support all level of
trainees in their grant development,
manuscript preparation, and as a forum
for research and career development.
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
2014 INSTITUTE
SEMINARS
Thomas Wichmann PhD
Yerkes Researcher,Yerkes National
Primate Research Center
Emory University
The thalamus in Parkinson’s Disease
01.31.13
Massimo Scanziani PhD
Professor, Section of Neurobiology
University of California San Diego
Investigator, HHMI
Cortical circuits of vision 3.20.14
John Huguenard PhD
Professor of Neurology & Neurological
Sciences
Stanford School of Medicine
Dissection and intervention of Thalamocortical microcircuits in epilepsy 10.30.14
James Booth PhD
Department Chair, Department of
Communication Sciences and
Disorders
John T. Jones, Jr. Centennial
Professorship in Communication
University of Texas at Austin
How does the brain learn to read
11.13.14
Distinguished Public Lecture 11.10.14
Annie Lin (right) with speaker Richard
Palmiter following his talk.
http://neuroscience.utsa.edu
ANNUAL REPORT Nº6
Undergraduate Outreach & Recruitment.
Many of you have been excellent ambassadors for the UTSA Neurobiology PhD
program by attending meetings and actively meeting with students to talk about our
program and your research. The Institute has sought to assist in undergraduate
research literacy and recruitment by assisting in the development of an
undergraduate Neuro Club, by building web resources with academic and
research guidance, and by fielding meetings with interested students to help advise
them more directly. The palpable increase in undergraduate interest in
Neuroscience research has led us to secure some generous funding from the Mind
Science Foundation to support a pair of summer undergraduate research
interns for a 6-8 week full-time research experience. If you have any students
whose career plans and interests make them candidates for a selective, authentic
and rigorous summer of neuroscience research, contact us.
Research Output
From 9.1.2013-8.31.2014:
❖ 18 proposals were submitted to federal agencies;
❖ 14 awards (new and continuing) were administered by the Institute.
❖ $1,670,832 was the total dollar value of award income;
❖ $2,013,250 in research expenditures were made by Investigators on Institute
sponsored grants *Data provided by UTSA VPR
Research Impact
Scholarly Output
Institute faculty generated at least 55 publications in 2014 (see Investigators
in Press). These include peer reviewed journal articles, invited reviews, and book
chapters. On a slightly less scholarly note, the Institute generated 17 research
themed podcasts as part of our Neuroscientists Talk Shop series. For the list of
titles featuring guest speakers, see box, p7.
The year ahead
Up ahead in 2015 Alfonso Apicella is organizing our annual Symposium. He
is assembling a panel to discuss how inhibition shapes information processing in
cortical microcircuits, and has already secured Dan Feldman (UC Berkeley),
Massimo Scanziani (HHMI/UCSD) and Lee Zhang (USC) for the panel.
In November, Annie Lin will be hosting adult neurogenesis and plasticity
pioneer Fred Gage (Salk Institute) for our Distinguished Public Lecture. Please help
spread the word about both events, to your labs, colleagues and students, alike.
2014
2014 NIH AWARDS
* NCE for 2014
R01NS072458 PI: Gaufo, GO
Morphogen-dependent Regulation of Motor
Neurogenesis along the A/P Axis
R01DA030530 PI: Paladini, Carlos A
The synaptic origin of reward prediction error
signal in dopaminergic neurons (parent & supp)
* R01HD045436 PI: Suter, Kelly J
Control of GnRH Neurons by Excitatory Circuitry
* R01HD060818 PI: Suter, Kelly J
Pubertal Control of GnRH Neurons
R00DA033386 PI: Wanat, Matthew J
CRF and Stress Modulation of Phasic Dopamine
Release and Behavior
*R03HD060756 PI: Wicha, Nicole Y
Brain Indices of Arithmetic Organization in
Bilinguals
* U54NS060658 PI: Wilson, Charles J
Quantitative Neurobiology at the University of
Texas San Antonio. Contains 6 components:
Subproject PIs: Gaufo, Ko, Paladini & Witt; 2
subcontract institutions: Medical University of
South Carolina & Geisinger Institute
P50NS047085 Co-PI: Wilson, Charles J
Rhythmicity and Synchrony in the Basal Ganglia
R01NS072197 PI: Wilson, Charles J
A Tonically Active Network in the Neostriatum
2014 NSF AWARDS
EF 1137897 PI: Santamaria, Fidel
Analyzing Neuronal Activity When Classical
Reaction-Diffusion Breaks Down
IOS 1208029 PI: Santamaria, Fidel
US-German Collaboration:The effects of chloride
dynamics in cerebellar computation dynamics in
cerebellar computation
IOS 1516648 PI: Santamaria, Fidel BRAIN
Inititative Awardees Meeting in Bethesda
DBI 1451032 Co-Is: Santamaria,Troyer,Wicha
BRAIN EAGER: Analyzing and Modeling Power-Law
Behaviors in Neuroscience
* IOS 0951310 PI: Troyer, Todd
Computational Investigation of vocal sequencing in
songbird.
Under other sponsorship:
SYMPOSIUM 2014
DMR 0934218 Co-I: Santamaria, Fidel
HRD 0932339 Co-I: Santamaria, Fidel
Neuron Regeneration, 10.27 & 10.28 2014
Also new for 2015:
From left: Bruce Appel (Colorado), Jenny Hsieh (UT Southwestern), Phil
Horner (U of WA), Tony Koleske (Yale), Annie Lin, Arnold Kriegstein (UCSF),
Vance Lemmon ((U Miami), and Bettina Winckler (U of Va).
Mind Science Foundation Summer 2015
Undergraduate Research Support Award
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
http://neuroscience.utsa.edu
ANNUAL REPORT Nº6
2014
Investigators in Press
Publications1 1.01.2014 - 12.31.2014
1.
Cordova A, Gabbard C. Do older adults perceive postural
constraints for reach estimation? Exp Aging Res. 2014;40(5):
578-88. doi: 10.1080/0361073X.2014.956627.
2.
Gonzalez J, Morales IS,Villarreal DM, Derrick BE. Lowfrequency stimulation induces long-term depression and
slow onset long-term potentiation at perforant path-dentate
gyrus synapses in vivo. J Neurophysiol. 2014 Mar;111(6):
1259-73.
3.
Zakaria S, Mao Y, Kuta A, Ferreira de Sousa C, Gaufo GO,
McNeill H, Hindges R, Guthrie S, Irvine KD, Francis-West
PH. Regulation of neuronal migration by Dchs1-Fat4 planar
cell polarity. Curr Biol. 2014 Jul 21;24(14):1620-7.
4.
Liu H, Flores MA, Meng J, Zhang L, Zhao X, Rao MK, Chen Y,
Huang Y. MeT-DB: a database of transcriptome
methylation in mammalian cells. Nucleic Acids Res. 2014
Nov 6. pii: gku1024.
5.
Flores M, Chen Y, Huang Y. TraceRNA: a web application
for competing endogenous RNA exploration. Circ
Cardiovasc Genet. 2014 Aug;7(4):548-57.
6.
Meng J, Lu Z, Liu H, Zhang L, Zhang S, Chen Y, Rao MK,
Huang Y. A protocol for RNA methylation differential
analysis with MeRIP-Seq data and exomePeak R/
Bioconductor package. Methods. 2014 Oct 1;69(3):274-81.
7.
Meng J, Merino LM, Robbins K, Huang Y. Classification
of imperfectly time-locked image RSVP events with EEG
device. Neuroinformatics. 2014 Apr;12(2):261-75.
8.
Z. Mao,V. Lawhern, L. M. Merino, K. Ball, L. Deng, B. J. Lance,
K. Robbins, Y. Huang, Classification of non-time-locked
rapid serial visual presentation events for brain-computer
interaction using deep learning, in 2014 IEEE China Summit
& International Conference on Signal and Information
Processing (ChinaSIP), Xi'an, China, 2014, pp. 520-524.
9.
Wang B, Jaffe DB, Brenner R. Current understanding of
iberiotoxin-resistant BK channels in the nervous system.
Front Physiol. 2014 Oct 9;5:382. Review.
10. Du X, Hao H, Gigout S, Huang D,Yang Y, Li L, Wang C, Sundt
D, Jaffe DB, Zhang H, Gamper N. Control of somatic
membrane potential in nociceptive neurons and its
implications for peripheral nociceptive transmission. Pain.
2014. Nov;155(11):2306-22.
11. Gaval-Cruz M, Goertz RB, Puttick DJ, Bowles DE, Meyer
RC, Hall RA, Ko D, Paladini CA, Weinshenker D. Chronic
loss of noradrenergic tone produces beta-arrestin2mediated cocaine hypersensitivity and alters cellular D2
responses in the nucleus accumbens. Addict Biol. 2014 Aug
13.
12. Sandstrom RS, Foret MR, Grow DA, Haugen E, Rhodes CT,
Cardona AE, Phelix CF, Wang Y, Berger MS, Lin CH.
Epigenetic regulation by chromatin activation mark
H3K4me3 in primate progenitor cells within adult
neurogenic niche. Sci Rep. 2014 Jun 20;4:5371.
1 Citations
13. Foret MR, Sandstrom RS, Rhodes CT, Wang Y, Berger MS,
Lin CH. Molecular targets of chromatin repressive mark
H3K9me3 in primate progenitor cells within adult
neurogenic niches. Front Genet. 2014 Jul 30;5:252.
14. Goertz RB, Wanat MJ, Gomez JA, Brown ZJ, Phillips PE,
Paladini CA. Cocaine Increases Dopaminergic Neuron
and Motor Activity via Midbrain Alpha Adrenergic Signaling.
Neuropsychopharmacology. 2014 Nov 6.
15. Paladini CA, Roeper J. Generating bursts (and pauses) in
the dopamine midbrain neurons. Neuroscience. 2014 Jul
27;282C:109-121. Review
16. Mohorovic L, Lavezzi AM, Stifter S, Perry G, Malatestinic D,
Micovic V, Materljan E, Haller H, Petrovic O.
Methemoglobinemia—a biomarker and a link to ferric iron
accumulation in Alzheimer’s disease. Adv Biosci Biotechnol
5:12-18, 2014.
17. Fawver JN, Ghiwot Y, Koola C, Carrera W, Rodriguez-Rivera
J, Hernandez C, Dineley KT, Kong Y, Li J, Jhamandas J, Perry
G, Murray IV. Islet Amyloid Polypeptide (IAPP): A Second
Amyloid in Alzheimer's Disease. Curr Alzheimer Res.
2014;11(10):928-40. PubMed PMID: 25387341.
18. Perry G. Looking at Alzheimer’s disease from a different
angle. Future Neurol 9:19-22, 2014.
19. Bowen RL, Perry G, Xiong C, Smith MA, Atwood CS. A
Clinical Study of Lupron Depot in the Treatment of Women
with Alzheimer's Disease: Preservation of Cognitive
Function in Patients Taking an Acetylcholinesterase Inhibitor
and Treated with High Dose Lupron Over 48 Weeks. J
Alzheimers Dis. 2014 Oct 13.
20. Xia J, Rocke DM, Perry G, Ray M. Differential network
analyses of Alzheimer's disease identify early events in
Alzheimer's disease pathology. Int J Alzheimers Dis.
2014;2014:721453.
21. Rodrigues R, Petersen RB, Perry G. Parallels between
major depressive disorder and Alzheimer's disease: role of
oxidative stress and genetic vulnerability. Cell Mol
Neurobiol. 2014 Oct;34(7):925-49.
22. Brinkley WR, Perry G. Lester (Skip) Binder (1949-2013): in
the beginning was tau. J Alzheimers Dis. 2014;40 Suppl 1:S5.
23. Bonda DJ, Wang X, Lee HG, Smith MA, Perry G, Zhu X.
Neuronal failure in Alzheimer's disease: a view through the
oxidative stress looking-glass. Neurosci Bull. 2014 Apr;30(2):
243-52. Review
24. Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ,
Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA,
Perry G, Zhu X, Lee HG. Accumulation of intraneuronal
amyloid is common in normal brain. Curr Alzheimer Res.
2014 May;11(4):317-24.
25. Bonda DJ, Wang X, Lee H-G, Smith MA, Perry G, Zhu X.
Neuronal failure in Alzheimer disease: a view through the
oxidative stress looking-glass. Neurosci Bull 30:243-252,
2014.
presented alphabetically by Institute Investigator.
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
http://neuroscience.utsa.edu
ANNUAL REPORT Nº6
26. Perry EA, Castellani RJ, Perry G. An epidemiological
approach to the study of Alzheimer’s disease. Int J Clin
Thera Diagn 2:301, 2014.
27. Castellani RJ, Perry G. Pathogenesis of Alzheimer’s disease.
In: Handbook of Neurotoxicity, Kostrzewa RM, Ed, Springer
Science+Business Media, New York, New York, 2014, pp
2327-2337.
28. Rosen AC, Ashford JW, Perry G. Ethics review as a catalyst
for progress. J Alzheimers Dis. 2014;40(2):233-5.
29. Perry G, Castellani R. Plaques and tangles: birthmarks of
the aging soul. Preface. Biochem Pharmacol. 2014 Apr 15;88
(4):423-5.
30. Castellani RJ, Perry G. The complexities of the pathologypathogenesis relationship in Alzheimer disease. Biochem
Pharmacol. 2014 Apr 15;88(4):671-6.
31. Johnston JM, Hu WT, Fardo DW, Greco SJ, Perry G,
Montine TJ, Trojanowski JQ, Shaw LM, Ashford JW, Tezapsidis
N; Alzheimer’s Disease Neuroimaging Initiative. Low plasma
leptin in cognitively impaired ADNI subjects: gender
differences and diagnostic and therapeutic potential. Curr
Alzheimer Res. 2014 Feb;11(2):165-74.
32. Wang X, Wang W, Li L, Perry G, Lee HG, Zhu X. Oxidative
stress and mitochondrial dysfunction in Alzheimer's disease.
Biochim Biophys Acta. 2014 Aug;1842(8):1240-7. Review.
33. 19: Mondragon-Rodriguez S, Perry G, Luna-Munoz J,
Acevedo-Aquino MC, Williams S. Phosphorylation of tau
protein at sites Ser(396-404) is one of the earliest events in
Alzheimer's disease and Down syndrome. Neuropathol Appl
Neurobiol. 2014 Feb;40(2):121-35.
34. Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio
R, Jicha G, Casadesus G, Smith MA, Zhu X, Lee HG.
Dysregulation of leptin signaling in Alzheimer disease:
evidence for neuronal leptin resistance. J Neurochem. 2014
Jan;128(1):162-72.
35. Ballard KJ, Tourville JA, Robin DA. Behavioral,
computational, and neuroimaging studies of acquired apraxia
of speech. Front Hum Neurosci. 2014 Nov 3;8:892.
36. Korzyukov O, Tapaskar N, Pflieger ME, Behroozmand R,
Lodhavia A, Patel S, Robin DA, Larson C. Event related
potentials study of aberrations in voice control mechanisms
in adults with attention deficit hyperactivity disorder. Clin
Neurophysiol. 2014 Sep 28. pii: S1388-2457(14)00501-X.
37. Manes JL, Parkinson AL, Larson CR, Greenlee JD, Eickhoff
SB, Corcos DM, Robin DA. Connectivity of the
subthalamic nucleus and globus pallidus pars interna to
regions within the speech network: a meta-analytic
connectivity study. Hum Brain Mapp. 2014 Jul;35(7):
3499-516.
38. Patel S, Nishimura C, Lodhavia A, Korzyukov O, Parkinson A,
Robin DA, Larson CR. Understanding the mechanisms
underlying voluntary responses to pitch-shifted auditory
feedback. J Acoust Soc Am. 2014 May;135(5):3036-44.
39. Flagmeier SG, Ray KL, Parkinson AL, Li K,Vargas R, Price LR,
Laird AR, Larson CR, Robin DA. The neural changes in
connectivity of the voice network during voice pitch
perturbation. Brain Lang. 2014 May;132:7-13.
1 Citations
2014
40. Parkinson AL, Behroozmand R, Ibrahim N, Korzyukov O,
Larson CR, Robin DA. Effective connectivity associated
with auditory error detection in musicians with absolute
pitch. Front Neurosci. 2014 Mar 5;8:46.
41. Behroozmand R, Ibrahim N, Korzyukov O, Robin DA,
Larson CR. Left-hemisphere activation is associated with
enhanced vocal pitch error detection in musicians with
absolute pitch. Brain Cogn. 2014 Feb;84(1):97-108.
42. Tate DF,York GE, Reid MW, Cooper DB, Jones L, Robin
DA, Kennedy JE, Lewis J. Preliminary findings of cortical
thickness abnormalities in blast injured service members
and their relationship to clinical findings. Brain Imaging
Behav. 2014 Mar;8(1):102-9.
43. Salinas K, Kereselidze Z, DeLuna F, Peralta XG,
Santamaria F. Transient extracellular application of gold
nanostars increases hippocampal neuronal activity. J
Nanobiotechnology. 2014 Aug 20;12(1):31.
44. Romero VH, Kereselidze Z, Egido W, Michaelides EA,
Santamaria F, Peralta XG. Nanoparticle assisted
photothermal deformation of individual neuronal organelles
and cells. Biomed Opt Express. 2014 Oct 20;5(11):4002-12.
45. Teka W, Marinov TM, Santamaria F. Neuronal spike timing
adaptation described with a fractional leaky integrate-andfire model. PLoS Comput Biol. 2014 Mar 27;10(3):e1003526.
46. Marinov TM, Santamaria F. Computational modeling of
diffusion in the cerebellum. Prog Mol Biol Transl Sci.
2014;123:169-89.
47. Willuhn I, Tose A, Wanat MJ, Hart AS, Hollon NG, Phillips
PE, Schwarting RK,Wöhr M. Phasic dopamine release in
the nucleus accumbens in response to pro-social 50 kHz
ultrasonic vocalizations in rats. J Neurosci. 2014 Aug 6;34
(32):10616-23.
48. Martinez-Lincoln A, Cortinas C, Wicha NY. Arithmetic
memory networks established in childhood are changed by
experience in adulthood. Neurosci Lett. 2015 Jan
1;584:325-30.
49. Ng S, Wicha NY. Processing gap-filler dependencies in
Chinese: What does it tell us about semantic processing? J
Mem Lang. 2014 Jul 1;74:16-35.
50. Ng S, Gonzalez C, Wicha NY. The fox and the cabra: an
ERP analysis of reading code switched nouns and verbs in
bilingual short stories. Brain Res. 2014 Apr 4;1557:127-40.
51. Guajardo LF, Wicha NY. Morphosyntax can modulate the
N400 component: event related potentials to gendermarked post-nominal adjectives. Neuroimage. 2014 May
1;91:262-72.
52. Wilson CJ. Oscillators and Oscillations in the Basal
Ganglia. Neuroscientist. 2014 Dec 1. pii:
1073858414560826. Review
53. Beatty JA, Song SC, Wilson CJ. Cell-type Specific
Resonances Shape the Responses of Striatal Neurons to
Synaptic Input. J Neurophysiol. 2014 Nov 19:jn.00827.2014.
54. Wilson CJ. The sensory striatum. Neuron. 2014 Sep 3;83
(5):999-1001.
55. Wilson CJ, Barraza D, Troyer T, Farries MA. Predicting
the responses of repetitively firing neurons to current
noise. PLoS Comput Biol. 2014 May 8;10(5):e1003612.
presented alphabetically by Institute Investigator.
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
http://neuroscience.utsa.edu
ANNUAL REPORT Nº6: APPENDIX 2014
Institute Investigators & Affiliations
Faculty
College
Submission/Award Data FY2010-14
Department
Science
Biology
Alberto Cordova
Education
Health & Kinesiology
Thomas Coyle
COLFA
Psychology
Brian Derrick
Science
Biology
Gary Gaufo
Science
Biology
Yufei Huang
Engineering
Electrical & Computer
David Jaffe
Science
Biology
Daijin Ko
Business
Statistics
Annie Lin
Science
Biology
Deborah Mangold
COLFA
Psychology
Carlos Paladini
Science
Biology
George Perry
Science
Biology
Robert Renthal
Science
Biology
Kay Robbins
Science
Computer Science
Donald A. Robin
Honors
Honors
4
Fidel Santamaria
Science
Biology
David Senseman
Science
Biology
3
Kelly Suter
Science
Biology
Todd Troyer
Science
Biology
Matt Wanat
Science
Biology
Nicole Wicha
Science
Biology
Charles Wilson
Science
Biology
Post-doc Fellows*
Idaira Oliva Padron
# of proposals
Alfonso Apicella
20
15
19
16 17
10
15
11
18
17 17
14
9
5
2010
2011
2012
2013
2014
# of Submitted and Awarded Grant Proposals 2010-14.
Submissions (blue) have decreased as Awards (purple; new, continuing,
revisions, supplements and extensions) have increased. New awards
follow submissions by one fiscal cycle (Source,VPR).
$ millions
Fiscal Snapshot All Years
3.54
2.51
2
1
0
Lab
Wanat
2.71
2.78
3.07
2.01
1.03
2008
2009
2010
2011
2012
2013
2014
Institute Expenditures since inception, in $millions. Dollar
amounts indicate expenses from federal grant accounts (Source, UTSA
VPR/Grants & Accounting).
Gerard Beaudoin-Research Faculty Paladini
Wilson
4
Matt Higgs -Research Faculty
Wilson
Songquing Lu
Santamaria
3
Toma Marinov (now @ Engineering) Santamaria
Wondimu Teka (now @ Purdue)
Santamaria
Shukhan Ng (now @ U of Illinois)
Wicha
*Postdocs who meet the qualifications to be Institute
Investigators are listed. All members must have published a
neuroscience research paper or abstract within the last 2
years.
$ millions
Ramana Dodla (now in Industry)
2.99
2
3.59
1
0
3.58
1.31
1.67
2010
2011
2012
2013
2014
Institute award income 2010-14, in $millions. Dollar amounts
indicate total costs awarded to UTSA (Source,VPR).
NEURO undergrads at Fiesta UTSA
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
http://neuroscience.utsa.edu
ANNUAL REPORT Nº6: APPENDIX 2014
Workshops 2008-2013 (academic year)
Distinguished Public Lectures 2008-2014
Year
Year
2008
Title
The R Statistical Language for Biologists
Image Deconvolution and Analysis
2009
2010
Neurostatistics: Statistical Models for
Counting Data & The Bootstrapping Method
Analyzing Neurons in 4 Dimensions
2011
Neurostatistics: Statistics in Neuroscience & Data
Mining
Analyzing Cell Morphology &
Movement Morphology & Movement in 3
Dimensions
2012
2009
2010
Nancy Wexler, PhD, Director, Hereditary Disease Foundation;
Professor of Neurology & Neuropsychology, Columbia University
Expansions on a Dream: From cause to cure of Huntington’s
Disease. 11.11.09
Neurostatistics: Experimental Design & ANOVA
for Biologists
Data Mining in Three Dimensions
An Introduction to Robust Statistics and R for
Biologists
Analyzing Cell Morphology &
Movement Morphology & Movement in 3
Dimensions II
Title
Christof Koch PhD, Professor of Computation and Neural
Systems, California Institute of Technology
The Neurobiology of Consciousness: What do we know and how
can we find out more? 05.05.09
Alice Wexler PhD, Research Scholar, UCLA
2010* Stigma, Secrecy & Medical History: What we can learn from
Huntington’s Disease. 11.10.09
2011
Anne Young MD PhD, Julieanne Dorn Professor, Harvard Med
Huntington’s Disease: From Gene to Therapy 03.24.11
2012
Erich Jarvis PhD, Associate Professor of Neurobiology, Duke
University Medical Center, Investigator, HHMI
Learned Birdsong & the Neurobiology of Human Language
04.24.12
2014
Richard Palmiter PhD, Professor of Biochemistry & Genomic
Sciences, University of Washington School of Medicine,
Investigator, HHMI
The Neural Circuits of Aversion: Learning to avoid bad situations.
11.10.14
* Companion lecture, partnered by American Studies Program
Symposia 2008-2014
Year
Title
2009
Ion Channels & Firing Properties of Dopamine
Neurons, panelists: Bruce Bean (Harvard); Jim
Surmeier (Northwestern); John Williams (Oregon
Health Sci U); Joachim Roeper (Goethe U,
Frankfurt), Carlos Paladini (UTSA)
2010
Wiring the CNS from Brain to Spinal Cord,
panelists: Pasko Rakic (Yale), Jeremy Dasen
(NYU), Goichi Miyaki (NYU), Raj Awatramani
(Northwestern), Gary Gaufo (UTSA)
2011
The Bilingual Brain, panelists: Judith Kroll (Penn
State), Lee Osterhout (UW Seattle), Karen
Emmorey (SD State), Nicole Wicha (UTSA)
2012
Neural Dynamics & Coding, panelists: Eugene
Izhikevich (BrainCorp/Scholarpedia), Eric SheaBrown (UW Seattle), Adrienne Fairhall (UW
Seattle), Uri Eden (Boston U), Todd Troyer (UTSA)
2013
Power Law Dynamics in the Brain, panelists:
Larry Abbot (Columbia), John Beggs (U of Indiana)
Dietmar Plenz (NIMH), Fidel Santamaria (UTSA)
2014
Neuron Regeneration, panelists: Bruce Appel (U
of CO), Phil Horner (U of WA), Jenny Hsieh (UT
Southwestern), Tony Koleske (Yale), Arnold
Kriegstein (UCSF), Annie Lin (UTSA), Vance
Lemmon (U of Miami), Bettina Winckler (U of VA)
2014 NTS PODCASTS
#107 Power
Law Dynamics Symposium
#108 Arnold Kriegstein (UCSF)
#109 Shaowen Bao (UC Berkeley)
#110 Richard Zigmond (Case Western)
#111 Nace Golding (UT Austin)
#112 Paul Colombo (Tulane)
#113 Patricio O’Donnell (Pfizer)
#114 Massimo Scanziani (HHMI UCSD)
#115 Todd Roberts (UT Southwestern)
#116 Larry Zweifel (U of Washington)
#117 Arturo Andrade (Lipscombe lab, Brown)
#118 Sam Sober (Emory & Georgia Tech)
#119 Michela Marinelli (UT Austin)
#120 Michael Drew (UT Austin)
#121 John Huguenard (Stanford)
#122 Thomas Hnasko (UCSD)
Pending for 2014: Seema Agarwal (UT Austin)
Main Site:
http://snrp.utsa.edu/Podcast/Podcast.html
iTunes Preview:
https://itunes.apple.com/us/podcast/neuroscientists-talk-shop/id279181187
THE UNIVERSITY OF TEXAS AT SAN ANTONIO NEUROSCIENCES INSTITUTE
http://neuroscience.utsa.edu