Life Sciences Industry Overview

B I R MIN GHAM
Life Sciences Industry Overview
With 1.1 million inhabitants and a GDP exceeding $58 billion,
the seven-county Birmingham region is the engine of the state
of Alabama and one of the leading metros of the southeastern
United States. It is also a leading life science hub. Birmingham
is home to the University of Alabama at Birmingham — an
outstanding American research university and one of the
largest academic medical centers in the country­ — as well as to
a vibrant biotechnology industry with well over 100 companies.
As a top-10 finance center in the nation, the Birmingham region
boasts competitive capital access with more than $2 billion in
active technology capital, ranging from research grants to latestage investments. Birmingham’s accomplished institutions and
companies are leading innovation in Alabama, the Southeast
and the world.
,
1
409
$2
Billion
A THRIVING BIOTECHNOLOGY INDUSTRY
Companies
Clinical Trials*
Capital
119
R&D (grant-funding)
Research Testing and Medical Labs
4
19
7
Phase 0
46
23
Drugs 22%
& Pharmaceuticals
47%
Medical Devices & Equipment
6%
27
Phase I
117
Early (equity in pre-revenue comp
401
Phase II
Expansion (equity in companies w
Bioscience-Related Distribution Phase III
growing revenue)
564
Later
(equity
and/or
debt
in compa
2%
Agricultural Feedstock & Chemicals
Phase IV
70 with profit)
23%
IOTECHNOLOGY INDUSTRY
R&D (grant-funding)
119 22%
TOTAL
ESTABLISHMENTS
$2 Billion
47%
Research Testing and Medical Labs
Drugs & Pharmaceuticals
6%
Medical Devices & Equipment
23%
Bioscience-Related Distribution
2%
Seed (non-dilutive funding)
Agricultural Feedstock & Chemicals
TAL ESTABLISHMENTS$2 Billion
Other
250
Seed (non-dilutive funding)
Early (equity in pre-revenue companies)
Expansion (equity in companies with
growing revenue)
Later (equity and/or debt in companies
with profit)
0
100
200
300
400
500
600
*1,020 of these trials were active at the
University of Alabama at Birmingham.
Retrieved from clinicaltrials.gov on June 9th, 2014.
Industry Innovators
AGRICULTURAL
FEEDSTOCK &
CHEMICALS
Aqua Services LLC
Dow Agrosciences LLC
Progressive Turf
Terraplan LLC
BIOSCIENCE-RELATED
DISTRIBUTION
Archer Daniels Midland Company
Bass Medical Inc.
Biolife Plasma Services L.P.
Bristol-Myers Squibb Company
Carefusion Solutions LLC
Cetec, Limited Liability Company
Crown Therapeutics Inc.
D & K Healthcare Resources Inc.
Janssen Pharmaceuticals
McKesson Corporation
Medaus Inc
Medfusionrx LLC
Origins Natural Resources Inc.
Promotional Concepts
Ri-Med Inc.
Russ Pharmaceuticals Inc
Salient Labs
Southern Surgical Technologies LLC
Spar Medical (prior Alabama Micro
Specialties Inc.)
Over 550 companies and 10,000 professionals support the bioscience industry across
the state of Alabama. The Birmingham area is home to 119 of these firms, spanning
multiple industry segments.
DRUGS &
PHARMACEUTICALS
MEDICAL DEVICES &
EQUIPMENT
RESEARCH TESTING
AND MEDICAL LABS
Advanced Skin Technologies
Aeon Bioscience
Agenta Biotechnologies
Aligon Pharmaceuticals
Amerisource Bergen
Aptalis Pharma Inc
Avanti Polar Lipids, inc
Axcan Pharma
Baxter Healthcare Corporation
Cebert Pharmaceuticals, Inc
Central Admixture Pharmacy
Services Inc.
Centrix Pharmaceuticals Inc
Deva Nutrition LLC
Evonik Industries *(1)
Gem Pharmaceuticals Inc.
Immunology Laboratories Inc.
Kor Therapies, Inc
Medaus, Inc
Nektar Therapeutics
Omega Pharmaceutical Inc.
Petnet Solutions Inc.
PNP Therapeutics Inc.
Prescription Benefits Inc
Progressive E M U Inc.
Protein Biosystems
Vector Logics, Inc
VistaPharm
3 D Medical Concepts LLC
Advanced Tear Diagnostics LLC
BioDtech Inc.
BioGx Inc.
Biohorizons Inc. *(2)
Bonenta Inc.
Compression Works LLC
Dermavista
Durect Inc
Endomimetics LLC
Foodsource Lures
Frontier Devices Inc.
Hayes Handpiece RPR
Hygia Health Inc.
Integrated Medical Systems
Ibbex Inc.
InTec Industries
Nidek Medical Products Inc.
Radiation Shielding Inc.
Synovis Micro Companies Alliance
Tingle X-Ray Products Inc.
VIPAAR Inc.
Vision Research Corporation
Adv Bioscience LLC
Alabama Clinical Therapeutics
Alabama Tissue Center Inc.
Alliance Clinical Research
Alpha Services
American Diagnostic Imaging
American Testing Laboratory Inc
Antech Diagnostics
Armstrong Testing Lab Inc
Atherotech Diagnostics Lab *(3)
Avanti Polar Lipids Inc.
Bendiner Lab
BET Reporductive Laboratories
Brookwood Biomedical
Cahaba Pathology, PC
Capstone Clinical Trials, Inc
Choice Research of Birmingham
Chrysallis Research
Laboratories Inc
Discovery BioMed Inc.
Dynacare Laboratories Inc
GE Clinical Services Inc.
Healthsouth Diagnostic
Center Inc.
Individualized Treatment
Technology Laboratories LLC
Lab Care
Lab First
Evonik Industries
(1)
Biohorizons Inc.
Lab of Medical Genetics
University of Alabama
Laboratory Corporation
of America
Laboratory Resources &
Solutions
MRI of Clanton
Quest Diagnostics Incorporated
Soluble Therapeutics *(4)
Southern Biotech
Southern Research Institute
St Clair Removable Dental
Sutherland Environmental
Company Inc.
Technical Assurance Corporation
TLC Mobile Medical LLC
Tuv Rheinland Industrial
Solutions Inc.
U S Diagnostic Labs Inc
Uab Pathology
Unified Testing Services Inc.
University Clinical Research
University of Alabama Health
Service Foundation PC
VIP Labs
Vivo Biosciences
Wearren Engineering Testing
(2)
Evonik Industries is a leader in bioresorbable polymer and injectable drug
delivery technologies. Evonik has opened its first U.S. Innovation Center in
Birmingham focused on medical devices and technology in 2014.
BioHorizons is one of the fastest-growing global implant and biologics
companies in the dental implant industry. Its portfolio of dental implants,
instruments and biologics products are sold in more than 85 markets
around the world.
Atherotech
Soluble Therapeutics
(3)
Atherotech specializes in cardiometabolic testing and disease management
solutions to enable health care professionals to more accurately assess
cardiovascular health and employ effective and personalized treatment strategies.
(4)
Soluble Therapeutics rapidly optimizes protein solubility and stability
enhancing the research, development and production of protein-based
therapeutics, vaccines and research tools.
Institutional Capabilites
The UAB Center for Clinical and
Translational Science is a targeted effort
to enhance the clinical and translational research
among a network of twelve of the Southeast’s most
cutting-edge research institutions. A
centralized physical and virtual hub
of Research Commons streamlines
resource accessibility and
support across the center,
which uniquely houses a Phase
I Clinical Trials Unit with 8,000
square feet of centralized firstin-human study capabilities.
With over $500 million in annual R&D expenditures at its major research
centers, over 1,400 active clinical trials and one of the largest U.S. academic
medical centers, the Birmingham-area bioscience technology capabilities and
resources are exceptional.
The University of Alabama at Birmingham (UAB)
is home to over 100 combined university-wide
interdisciplinary research centers and core facilities,
aimed to enhance UAB’s contribution to new
knowledge and economic growth: http://
www.uab.edu/research/administration.
An example of the university’s
commitment to research discovery
is the recently expanded Central
Alabama High Field Nuclear
Magnetic Resonance (NMR)
facility, housing the highest field
NMR (Bruker Avance III HD 850
with cryoprobe) in the state and
one of the largest in the U.S.
The UAB
Comprehensive
Cancer Center
is the only National
Cancer Institute
designated cancer
center in the Deep
South region of the
United States. It is home
to over 330 researchers
and clinicians, focused on
the fields of gene therapy,
immunotherapy and drug
discovery and development.
The center treats an
estimated 5,000 new patients
each year, including those
participating in many clinical trials
to target a broad array of cancers,
including breast, gastrointestinal tract,
lung, ovary, head and neck, brain tumors,
and lymphomas.
Innovation Depot
is one of the leading
technology incubators in
the world. The 140,000
square-foot facility
includes 20,000 square
feet of wet lab space and a
shared equipment lab with
common instrumentation.
The program houses
90 companies (14 in
biotechnology) with 540 total
employees, operating in all
50 states and over 40 countries,
contributing $1.25 billion in
economic impact to the region over
the past five years.
The Alabama Drug
Discovery Alliance is a drug
Southern Research
Institute is a contract
research organization
headquartered in Birmingham.
With over half a million
square feet of wet lab space,
the organization provides
comprehensive contract research
services in basic discovery research, invitro and in-vivo efficacy; ADME/PK; GLP toxicology
and reproductive toxicology; gene therapy/biologics;
method feasibility, development and validation;
formulation and bioanalysis; qPCR and RT-PCR.
discovery and development
partnership with crossinstitutional capabilities in
molecular target identification,
high throughput screening,
iterative medicinal chemistry,
preclinical toxicology and absorption,
distribution, metabolism and excretion
(ADME) analysis, and clinical trials. The
current portfolio encompasses 17 drug discovery programs
with a primary focus on the central nervous system and
oncology, although other therapeutic areas such as
diabetes and infectious diseases are touched upon as well.
Resources
and incentives
Alabama Research Economy
The Birmingham region and the state of Alabama
have a strong economic development track record
and a solid history of companies swiftly integrating
and thriving in our community. As a recent example,
Evonik Industries - a world leader in specialty
chemicals - recently announced a global Innovation
Center for research and development (R&D) of
medical devices and technology at the company’s
Birmingham facility.
Both the region and state have emphasized in
long-range economic growth plans the crucial
importance of technology and innovation to
continued growth and prosperity. As part of
Accelerate Alabama, the state’s long-term plan for
economic development, the Alabama Innovation
Fund was recently formed to support research and
economic development. The Birmingham Business
Alliance (BBA), the leading economic development
organization in the Birmingham seven-county
region, supports a Commercialization Advisory
Committee and life science industry Leadership
Councils, which provide forums for senior leaders
from across the business, policy, capital, academic
and entrepreneur communities to promote and
grow innovation pathways for enhanced technology
growth in the Birmingham region. Alabama and
the Birmingham region offer a strong innovation
ecosystem with a number of support organizations,
such as BioAlabama, TechBirmingham, the
Birmingham Venture Club and the Central Alabama
Angel Network.
For talent recruitment and development, AIDT,
the state’s award-winning and no. 1 nationally
ranked workforce recruitment and training
program, is available to help identify, recruit and
train a high-quality and skilled workforce at no
cost to companies looking to locate or expand
within the state of Alabama. The University of
Alabama at Birmingham and other area colleges
and universities have a strong graduate pipeline,
providing a skilled workforce with training
specifically geared toward the biotechnology
industry. Attractive and competitive incentives are
available for companies looking to grow in
the region.
For more information on the Birmingham region, contact
Steven Ceulemans
Vice President of Innovation and Technology
(205) 241-8122
sceulemans@birminghambusinessalliance.com
www.birminghambusinessalliance.com
NASHVILLE
MEMPHIS
ATLANTA
BI R M I N GHA M
With
4 ho in
urs
Alabama:
$3.7 billion annual R&D
expenditures, most R&D
intensive state in the
Southeast
1st quartile
2nd quartile
3rd quartile
4th quartile
Source: National Science Foundation Science and Engineering Indicators, 2014.
Alabama ranks No. 8 in the U.S. for
biopharmaceutical job creation ­— 62% of
those jobs were created in Birmingham
­­—Site Selection Magazine and Clustermapping US