IVISbibliography FINAL-August 2011

Transcription

IVISbibliography FINAL-August 2011
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Bibliography of Peer-reviewed IVIS Publications
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Abate A, Yang G, Wong RJ, Schroder H, Stevenson DK, Dennery PA. Apigenin decreases hemin-mediated heme
oxygenase-1 induction. Free Radical Biology and Medicine. 2005;39:711-718
Abate A, Zhao H, Wong RJ, Stevenson DK. The role of bach1 in the induction of heme oxygenase by tin
mesoporphyrin. Biochemical and Biophysical Research Communications. 2007;354:757-763
Abdel-Azim H, Zhu Y, Hollis R, Wang X, Ge S, Hao QL, Smbatyan G, Kohn DB, Rosol M, Crooks GM. Expansion
of multipotent and lymphoid-committed human progenitors through intracellular dimerization of mpl. Blood.
2008;111:4064-4074
Abdelkarim M, Guenin E, Sainte-Catherine O, Vintonenko N, Peyri N, Perret GY, Crepin M, Khatib AM, Lecouvey
M, Di Benedetto M. New symmetrically esterified m-bromobenzyl non-aminobisphosphonates inhibited breast
cancer growth and metastases. PLoS One. 2009;4
Aboody KS, Bush RA, Garcia E, Metz MZ, Najbauer J, Justus KA, Phelps DA, Remack JS, Yoon KJ, Gillespie S,
Kim SU, Glackin CA, Potter PM, Danks MK. Development of a tumor-selective approach to treat metastatic cancer.
PLoS One. 2006;1
Abraham J, Prajapati SI, Nishijo K, Schaffer BS, Taniguchi E, Kilcoyne A, McCleish AT, Nelon LD, Giles FG,
Efstratiadis A, LeGallo RD, Nowak BM, Rubin BP, Malempati S, Keller C. Evasion mechanisms to igf1r inhibition
in rhabdomyosarcoma. Mol Cancer Ther. 2011;10:697-707
Abraham U, Prior JL, Granados-Fuentes D, Piwnica-Worms DR, Herzog ED. Independent circadian oscillations of
period1 in specific brain areas in vivo and in vitro. J Neurosci. 2005;25:8620-8626
Abrams TJ, Murray LJ, Pesenti E, Holway VW, Colombo T, Lee LB, Cherrington JM, Pryer NK. Preclinical
evaluation of the tyrosine kinase inhibitor su11248 as a single agent and in combination with "standard of care"
therapeutic agents for the treatment of breast cancer. Molecular Cancer Therapy. 2003;2:1011-1021
Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z,
Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS, Guttridge DC. Interplay of ikk/nfκb signaling in macrophages and myofibers promotes muscle degeneration in duchenne muscular dystrophy.
Journal of Clinical Investigation. 2007;117:889-901
Acuff H, Carter K, Fingleton B, Gorden D, Matrisian L. Matrix metalloproteinase-9 from bone marrow–derived
cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res.
2006;66:259
Acuff HB, Carter KJ, Fingleton B, Gorden DL, Matrisian LM. Mmp9 from bone marrow-derived cells contributes
to survival but not growth of tumor cells in the lung microenvironment. Cancer Res. 2006;66:259-266
Adachi T, Kawakami E, Ishimaru N, Ochiya T, Hayashi Y, Ohuchi H, Tanihara M, Tanaka E, Noji S. Delivery of
small interfering rna with a synthetic collagen poly (pro hyp gly) for gene silencing in vitro and in vivo.
Development, Growth & Differentiation. 2010;52:693-699
Adams JY, Johnson M, Sato M, Berger F, Gambhir SS, Carey M, Iruela-Arispe ML, Wu L. Visualization of
advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging.
Nature Medicine. 2002;8:891-897
Agrawal VK, Copeland KM, Barbachano Y, Rahim A, Seth R, White CL, Hingorani M, Nutting CM, Kelly M, Harris
P, Pandha H, Melcher AA, Vile RG, Porter C, Harrington KJ. Microvascular free tissue transfer for gene delivery: In
vivo evaluation of different routes of plasmid and adenoviral delivery. Gene Ther. 2009;16:78-92
Ahlén G, Derk E, Weiland M, Jiao J, Rahbin N, Aleman S, Peterson DL, Pokrovskaja K, Grandér D, Frelin L,
Sällberg M. Cleavage of the ips-1/cardif/mavs/visa does not inhibit t cell-mediated elimination of hepatitis c
virus non-structural 3/4a-expressing hepatocytes. Gut. 2009;58:560-569
Ahlen G, Soderholm J, Tjelle T, Kjeken R, Frelin L, Hoglund U, Blomberg P, Fons M, Mathiesen I, Sallberg M. In
vivo electroporation enhances the immunogenicity of hepatitis c virus nonstructural 3/4a DNA by increased
local DNA uptake, protein expression, inflammation, and infiltration of cd3+ t cells. J Immunol.
2007;179:4741-4753
Ahmad S, Casey G, Cronin M, Rajendran S, Sweeney P, Tangney M, O'Sullivan GC. Induction of effective
antitumor response after mucosal bacterial vector mediated DNA vaccination with endogenous prostate cancer
specific antigen. The Journal of urology. 2011;186:687-693
Ahmad S, Casey G, Sweeney P, Tangney M, O'Sullivan GC. Optimised electroporation mediated DNA vaccination
for treatment of prostate cancer. Genet Vaccines Ther. 2010;8:1
Ahmadi M, King JW, Xue SA, Voisine C, Holler A, Wright GP, Waxman J, Morris E, Stauss HJ. Cd3 limits the
efficacy of tcr gene therapy in vivo. Blood. 2011
Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD,
Weiss HL, Rooney CM, Heslop HE, Gottschalk S. Regression of experimental medulloblastoma following transfer
of her2-specific t cells. Cancer Res. 2007;67:5957-5964
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Ahmed N, Salsman VS, Kew Y, Shaffer D, Powell S, Zhang YJ, Grossman RG, Heslop HE, Gottschalk S. Her2specific t cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors.
Clin Cancer Res. 2010;16:474-485
Ahmed N, Salsman VS, Yvon E, Louis CU, Perlaky L, Wels WS, Dishop MK, Kleinerman EE, Pule M, Rooney CM,
Heslop HE, Gottschalk S. Immunotherapy for osteosarcoma: Genetic modification of t cells overcomes low levels
of tumor antigen expression. Mol Ther. 2009;17:1779-1787
Ahonen MT, Diaconu I, Pesonen S, Kanerva A, Baumann M, Parviainen ST, Spiller B, Cerullo V, Hemminki A.
Calcium gluconate in phosphate buffered saline increases gene delivery with adenovirus type 5. PLoS One.
2010;5
Aigner J, Staudenmaier R, Rotter N, Kloppel M, Radice M, Pavesio A, Naumann A. Cartilage tissue engineering
using scaffolds of hyaluronan benzyl esters for reconstructive head and neck surgery. In: Abatangelo G, Weigel
PH, eds. New frontiers in medical sciences: Redefining hyaluronan. Amsterdam: Elsevier Science Bv;
2000:255-265.
Akar U, Ozpolat B, Mehta K, Lopez-Berestein G, Zhang D, Ueno N, Hortobagyi G, Arun B. Targeting p70s6k
prevented lung metastasis in a breast cancer xenograft model. Mol Cancer Ther. 2010;9:1180
Akcan M, Stroud MR, Hansen SJ, Clark RJ, Daly NL, Craik DJ, Olson JM. Chemical re-engineering of chlorotoxin
improves bioconjugation properties for tumor imaging and targeted therapy. Journal of medicinal chemistry.
2011
Akens M, Hardisty M, Wilson B, Schwock J, Whyne C, Burch S, Yee A. Defining the therapeutic window of
vertebral photodynamic therapy in a murine pre-clinical model of breast cancer metastasis using the
photosensitizer bpd-ma (verteporfin). Breast Cancer Res Treat. 2010;119:325-333
Akens MK, Yee AJ, Wilson BC, Burch S, Johnson CL, Lilge L, Bisland SK. Photodynamic therapy of vertebral
metastases: Evaluating tumor-to-neural tissue uptake of bpd-ma and ala-ppix in a murine model of metastatic
human breast carcinoma. Photochem Photobiol. 2007;83:1034-1039
Akimoto T, Li P, Yan Z. Functional interaction of regulatory factors with the pgc-1{alpha} promoter in response
to exercise by in vivo imaging. Am J Physiol Cell Physiol. 2008
Akimoto T, Sorg B, Yan Z. Activity in skeletal muscles of living mice. Journal of Applied Physiology.
2007;103:1536-1542
Optical bioluminescence imaging. In vivo bioluminescence
images were acquired under anesthesia (1550 mg/kg ip pentobarbital sodium) with
the IVIS system (Xenogen). Repeated measurements were ...
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Alain T, Lun X, Martineau Y, Sean P, Pulendran B, Petroulakis E, Zemp FJ, Lemay CG, Roy D, Bell JC, Thomas G,
Kozma SC, Forsyth PA, Costa-Mattioli M, Sonenberg N. Vesicular stomatitis virus oncolysis is potentiated by
impairing mtorc1-dependent type i ifn production. Proc Natl Acad Sci U S A. 2010;107:1576-1581
32.
Alaniz L, Rizzo M, Garcia MG, Piccioni F, Aquino JB, Malvicini M, Atorrasagasti C, Bayo J, Echeverria I, Sarobe
P, Mazzolini G. Low molecular weight hyaluronan preconditioning of tumor-pulsed dendritic cells increases
their migratory ability and induces immunity against murine colorectal carcinoma. Cancer immunology,
immunotherapy : CII. 2011
33.
Albiger B, Sandgren A, Katsuragi H, Meyer Hoffert U, Beiter K, Wartha F, Hornef M, Normark S, Normark B.
Myeloid differentiation factor 88 dependent signalling controls bacterial growth during colonization and
systemic pneumococcal disease in mice. Cellular Microbiology. 2005;7:1603-1615
34.
Alizadeh D, Zhang L, Brown C, Farrukh O, Jensen M, Badie B. Induction of anti-glioma natural killer cell
response following multiple low-dose intracerebral cpg therapy. Clinical Cancer Research. 2010;16:3399
35.
Alizadeh D, Zhang L, Hwang J, Schluep T, Badie B. Tumor-associated macrophages are predominant carriers of
cyclodextrin-based nanoparticles into gliomas. Nanomedicine: Nanotechnology, Biology and Medicine.
2010;6:382-390
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Allard M, Côté D, Davidson L, Dazai J, Henkelman R. Combined magnetic resonance and bioluminescence
imaging of live mice. Journal of biomedical optics. 2007;12:034018
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Almog N, Henke V, Flores L, Hlatky L, Kung A, Wright R, Berger R, Hutchinson L, Naumov G, Bender E.
Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis. The FASEB Journal.
2006;20:947
38.
Alonso M, Cascallo M, Gomez-Manzano C, Jiang H, Bekele B, Perez-Gimenez A, Lang F, Piao Y, Alemany R,
Fueyo J. Icovir-5 shows e2f1 addiction and potent antiglioma effect in vivo. Cancer Res. 2007;67:8255
39.
Alphs HH, Gambhira R, Karanam B, Roberts JN, Jagu S, Schiller JT, Zeng W, Jackson DC, Roden RBS. Protection
against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly
cross-neutralizing epitope of l2. Proceedings of the National Academy of Sciences of the United States of
America. 2008;105:5850-5855
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Alter J, Sennoga CA, Lopes DM, Eckersley RJ, Wells DJ. Microbubble stability is a major determinant of the
efficiency of ultrasound and microbubble mediated in vivo gene transfer. Ultrasound Med Biol.
2009;35:976-984
41.
Amagai Y, Matsumoto M, Hojo K, Iguchi M, Wada T, Tanaka H, Ide N, Kato A, Shichijo M, Abe K. Combination
therapy of interleukin-2 and sorafenib improves survival benefits and prevents spontaneous pulmonary
metastasis in murine renal cell carcinoma models. Jpn J Clin Oncol. 2010
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Amante F, Haque A, Stanley A, Rivera F, Randall L, Wilson Y, Yeo G, Pieper C, Crabb B, de Koning-Ward T.
Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria. The Journal
of Immunology. 2010;185:3632
Amante FH, Engwerda CR, Good MF. Experimental asexual blood stage malaria immunity. Current protocols in
immunology / edited by John E. Coligan ... [et al.]. 2011;Chapter 19:Unit 19 14
Amante FH, Stanley AC, Randall LM, Zhou Y, Haque A, McSweeney K, Waters AP, Janse CJ, Good MF, Hill GR,
Engwerda CR. A role for natural regulatory t cells in the pathogenesis of experimental cerebral malaria. American
Journal of Pathology. 2007;171:548-559
Amiq G, Bilici M, Pierog J, Ayuni E, Gugger M, Wetterwald A, Cecchini M, Schmid R. In vivo electroporation
and ubiquitin promoter - a protocol for sustained gene expression in the lung. The Journal of Gene Medicine.
2006;8:910-918
Amos S, Mut M, diPierro CG, Carpenter JE, Xiao A, Kohutek ZA, Redpath GT, Zhao Y, Wang J, Shaffrey ME,
Hussaini IM. Protein kinase c-α–mediated regulation of low-density lipoprotein receptor–related protein and
urokinase increases astrocytoma invasion. Cancer Res. 2007;67:10241-10251
An CI, Trinh VB, Yokobayashi Y. Artificial control of gene expression in mammalian cells by modulating rna
interference through aptamer–small molecule interaction. RNA. 2006;12:710-716
Anderson MZ, Brewer J, Singh U, Boothroyd JC. A pseudouridine synthase homologue is critical to cellular
differentiation in toxoplasma gondii. Eukaryot Cell. 2009;8:398-409
Anderson PH, Hendrix I, Sawyer RK, Zarrinkalam R, Manavis J, Sarvestani GT, May BK, Morris HA. Co-expression
of cyp27b1 enzyme with the 1.5kb cyp27b1 promoter-luciferase transgene in the mouse. Mol Cell Endocrinol.
2008;285:1-9
Andonegui G, Zhou H, Bullard D, Kelly MM, Mullaly SC, McDonald B, Long EM, Robbins SM, Kubes P. Mice
that exclusively express tlr4 on endothelial cells can efficiently clear a lethal systemic gram-negative bacterial
infection. Journal of Clinical Investigation. 2009;119:1921-1930
Andreeff M, Dembinski J, Hall BM, Studeny M, Ling X, Cabreira-Hansen M, Kate Sasser A, McQueen T, Lang F,
Marini FC. Mesenchymal stem cells selectively engraft into tumor stroma and produce potent antitumor proteins
in situ. Blood. 2006;108:109A
Andreeff M, Dembinski J, Studeny M, Ling X, Hansen M, Zompetta C, McQueen T, Fueyo J, Champlin R, Marini F.
Mesenchymal progenitor cells as gene delivery systems for cancer therapy: Tropism and efficacy. Proceedings of
the American Association for Cancer Research. 2005;2005:1254
Andreu N, Zelmer A, Fletcher T, Elkington PT, Ward T, Ripoll J, Parish T, Bancroft G, Schaible U, Robertson B,
Wiles S. Optimisation of bioluminescent reporters for use with mycobacteria. PLoS ONE. 2010
Aneja M, Imker R, Rudolph C. Phage phic31 integrase-mediated genomic integration and long-term gene
expression in the lung after nonviral gene delivery. The Journal of Gene Medicine. 2007;9:967-975
Aneja R, Miyagi T, Karna P, Ezell T, Shukla D, Vij Gupta M, Yates C, Chinni S, Zhau H, Chung L. A novel
microtubule-modulating agent induces mitochondrially driven caspase-dependent apoptosis via mitotic
checkpoint activation in human prostate cancer cells. European Journal of Cancer. 2010;46:1668-1678
Antczak C, Kloepping C, Radu C, Genski T, Muller-Kuhrt L, Siems K, de Stanchina E, Abramson DH, Djaballah H.
Revisiting old drugs as novel agents for retinoblastoma: In vitro and in vivo antitumor activity of cardenolides.
Invest Ophthalmol Vis Sci. 2009
Aoi A, Watanabe Y, Mori S, Takahashi M, Vassaux G, Kodama T. Herpes simplex virus thymidine kinase-mediated
suicide gene therapy using nano/microbubbles and ultrasound. Ultrasound Med Biol. 2007
Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR, Davis RW, Tompkins RG, Rahme
LG. Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following
trauma. PLoS One. 2007;2
Arao Y, Hakamata Y, Igarashi Y, Sato Y, Kayama F, Takahashi M, Kobayashi E, Murakami T. Characterization of
hepatic sexual dimorphism in alb-dsred2 transgenic rats. Biochem Biophys Res Commun. 2009;382:46-50
Aravalli RN, Hu S, Lokensgard JR. Inhibition of toll-like receptor signaling in primary murine microglia. J
Neuroimmune Pharmacol. 2008;3:5-11
Aravalli RN, Hu S, Woods JP, Lokensgard JR. Histoplasma capsulatum yeast phase-specific protein yps3p
induces toll-like receptor 2 signaling. J Neuroinflammation. 2008;5:30
Arenas F, Hervias I, Úriz M, Joplin R, Prieto J, Medina JF. Combination of ursodeoxycholic acid and
glucocorticoids upregulates the ae2 alternate promoter in human liver cells. Journal of Clinical Investigation.
2008;118:695-709
Argyros O, Wong SP, Fedonidis C, Tolmachov O, Waddington SN, Howe SJ, Niceta M, Coutelle C, Harbottle RP.
Development of s/mar minicircles for enhanced and persistent transgene expression in the mouse liver. Journal
of molecular medicine. 2011;89:515-529
Arita Y, Harkness S, Kazzaz J, Koo H, Joseph A, Melendez J, Davis J, Chander A, Li Y. Mitochondrial localization
of catalase provides optimal protection from h2o2-induced cell death in lung epithelial cells. American Journal
of Physiology- Lung Cellular and Molecular Physiology. 2006;290:L978
Armstrong SA, Kung AL, Mabon ME, Silverman LB, Stam RW, Den Boer ML, Pieters R, Kersey JH, Sallan SE,
Fletcher JA, Golub TR, Griffin JD, Korsmeyer SJ. Inhibition of flt3 in mll. Validation of a therapeutic target
identified by gene expression based classification. Cancer Cell. 2003;3:173-183
Arnold RS, Sun CQ, Richards JC, Grigoriev G, Coleman IM, Nelson PS, Hsieh CL, Lee JK, Xu Z, Rogatko A,
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Osunkoya AO, Zayzafoon M, Chung L, Petros JA. Mitochondrial DNA mutation stimulates prostate cancer growth
in bone stromal environment. Prostate. 2009;69:1-11
Arpaia E, Blaser H, Quintela-Fandino M, Duncan G, Leong HS, Ablack A, Nambiar SC, Lind EF, Silvester J,
Fleming CK, Rufini A, Tusche MW, Brustle A, Ohashi PS, Lewis JD, Mak TW. The interaction between caveolin-1
and rho-gtpases promotes metastasis by controlling the expression of alpha5-integrin and the activation of src,
ras and erk. Oncogene. 2011
Artemov D, Kato Y, Zhu W, Raman V, Bhujwalla ZM. Assessing tumor response to anti-angiogenic therapy with
novel dce-mri method. Proceedings of the American Association for Cancer Research Annual Meeting.
2010;51:1271
Arumugam T, Ramachandran V, Logsdon C. Effect of cromolyn on s100p interactions with rage and pancreatic
cancer growth and invasion in mouse models. Journal of the National Cancer Institute. 2006;98:1806
Arumugam T, Simeone DM, Van Golen K, Logsdon CD. S100p promotes pancreatic cancer growth, survival, and
invasion. Clin Cancer Res. 2005;11:5356-5364
Asakura A, Hirai H, Kablar B, Morita S, Ishibashi J, Piras BA, Christ AJ, Verma M, Vineretsky KA, Rudnicki MA.
Increased survival of muscle stem cells lacking the myod gene after transplantation into regenerating skeletal
mu s cl e. Pr o ceed i n g s o f t h e Na t i o n a l Aca d emy o f S ci en ces o f t h e Un i t ed S t a t es o f Amer i ca .
2007;104:16552-16557
Asgharpour A, Gilchrist C, Baba D, Hamano S, Houpt E. Resistance to intestinal entamoeba histolytica infection
is conferred by innate immunity and gr-1+ cells. Infection and Immunity. 2005;73:4522-4529
Asokan A, Hamra JB, Govindasamy L, Agbandje-McKenna M, Samulski RJ. Adeno-associated virus type 2
contains an integrin α5β1 binding domain essential for viral cell entry. J Virol. 2006;80:8961-8969
Asokan A, Johnson JS, Li C, Samulski RJ. Bioluminescent virion shells: New tools for quantitation of aav vector
dynamics in cells and live animals. Gene Therapy. 2008;15:1618-1622
Assem M, Schuetz E, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans R. Interactions
between hepatic mrp4 and sult2a as revealed by the constitutive androstane receptor and mrp4 knockout mice.
Journal of Biological Chemistry. 2004;279:22250
Auld DS, Thorne N, Maguire WF, Inglese J. Mechanism of ptc124 activity in cell-based luciferase assays of
nonsense codon suppression. Proc Natl Acad Sci U S A. 2009
Aung W, Hasegawa S, Koshikawa-Yano M, Obata T, Ikehira H, Furukawa T, Aoki I, Saga T. Visualization of in vivo
electroporation-mediated transgene expression in experimental tumors by optical and magnetic resonance
imaging. Gene Ther. 2009;16:830-839
Aung W, Hasegawa S, Koshikawa-Yano M, Tsuji AB, Sogawa C, Sudo H, Sugyo A, Koizumi M, Furukawa T, Saga T.
Noninvasive assessment of regulable transferred-p53 gene expression and evaluation of therapeutic response
with fdg-pet in tumor model. Gene Ther. 2010
Aung W, Sogawa C, Furukawa T, Saga T. Anticancer effect of dihydroartemisinin (dha) in a pancreatic tumor
model evaluated by conventional methods and optical imaging. Anticancer research. 2011;31:1549-1558
Azab AK, Runnels JM, Pitsillides C, Moreau AS, Azab F, Leleu X, Jia X, Wright R, Ospina B, Carlson AL, Alt C,
Burwick N, Roccaro AM, Ngo HT, Farag M, Melhem MR, Sacco A, Munshi NC, Hideshima T, Rollins BJ, Anderson
KC, Kung AL, Lin CP, Ghobrial IM. Cxcr4 inhibitor amd3100 disrupts the interaction of multiple myeloma cells
with the bone marrow microenvironment and enhances their sensitivity to therapy. Blood. 2009;113:4341-4351
Azadniv M, Bowers WJ, Topham DJ, Crispe IN. Cd4+ t cell effects on cd8+ t cell location defined using
bioluminescence. PloS one. 2011;6:e16222
Azadniv M, Dugger K, Bowers WJ, Weaver C, Crispe IN. Imaging cd8+ t cell dynamics in vivo using a transgenic
luciferase reporter. Int Immunol. 2007;19:1165-1173
Baba S, Cho S, Ye Z, Cheng L, Wahl R. Mouse lymphoma model for monitoring the tumor growth and effects of
immunoradiotherapy using a non-invasive in vivo optical imaging system. The Journal of Nuclear Medicine.
2006;47 supplement:431P
Baba S, Cho S, Ye Z, Cheng L, Wahl R. Assessing radio immunotherapy of disseminated lymphomas with noninvasive in vivo bioluminescence. Soc Nuclear Med. 2007;48:346P
Backer R, Schwandt T, Greuter M, Oosting M, Jungerkes F, Tuting T, Boon L, O'Toole T, Kraal G, Limmer A, den
Haan JM. Effective collaboration between marginal metallophilic macrophages and cd8+ dendritic cells in the
generation of cytotoxic t cells. Proc Natl Acad Sci U S A. 2010;107:216-221
Badiga AV, Chetty C, Kesanakurti D, Are D, Gujrati M, Klopfenstein JD, Dinh DH, Rao JS. Mmp-2 sirna inhibits
radiation-enhanced invasiveness in glioma cells. PloS one. 2011;6:e20614
Bae CJ, Lee JW, Bae HS, Shim SB, Jee SW, Lee SH, Lee CK, Hong JT, Hwang DY. Detection of allergenic
compounds using an il-4/luciferase/cns-1 transgenic mice model. Toxicological sciences : an official journal of
the Society of Toxicology. 2011;120:349-359
Baffert F, Regnier CH, De Pover A, Pissot-Soldermann C, Tavares GA, Blasco F, Brueggen J, Chene P, Drueckes P,
Erdmann D, Furet P, Gerspacher M, Lang M, Ledieu D, Nolan L, Ruetz S, Trappe J, Vangrevelinghe E, Wartmann M,
Wyder L, Hofmann F, Radimerski T. Potent and selective inhibition of polycythemia by the quinoxaline jak2
inhibitor nvp-bsk805. Mol Cancer Ther. 2010;9:1945-1955
Bagnara D, Ibatici A, Corselli M, Sessarego N, Tenca C, De Santanna A, Mazzarello A, Daga A, Corvò R, De Rossi
G, Frassoni F, Ciccone E, Fais F. Adoptive immunotherapy mediated by ex vivo expanded natural killer t cells
against cd1d-expressing lymphoid neoplasms. Haematologica. 2009;94:967-974
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Bahey-El-Din M, Casey PG, Griffin BT, Gahan CG. Lactococcus lactis-expressing listeriolysin o (llo) provides
protection and specific cd8(+) t cells against listeria monocytogenes in the murine infection model. Vaccine.
2008;26:5304-5314
Bai S, Nasser MW, Wang B, Hsu SH, Datta J, Kutay H, Yadav A, Nuovo G, Kumar P, Ghoshal K. Microrna-122
inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib*.
Journal of Biological Chemistry. 2009;284:32015-32027
Bai X, Yan Y, Song YH, Seidensticker M, Rabinovich B, Metzele R, Bankson JA, Vykoukal D, Alt E. Both cultured
and freshly isolated adipose tissue-derived stem cells enhance cardiac function after acute myocardial infarction.
Eur Heart J. 2010;31:489-501
Baia G, Dinca E, Ozawa T, Kimura E, McDermott M, James C, VandenBerg S, Lal A. An orthotopic skull base model
of malignant meningioma. Brain Pathology. 2008;18:172-179
Bailey CL, Kelly P, Casey PJ. Activation of rap1 promotes prostate cancer metastasis. Cancer Res.
2009;69:4962-4968
Bais M, Wigner N, Young M, Toholka R, Graves D, Morgan E, Gerstenfeld L, Einhorn T. Bmp2 is essential for post
natal osteogenesis but not for recruitment of osteogenic stem cells. Bone. 2009;45:254-266
Baker AM, Cox TR, Bird D, Lang G, Murray GI, Sun XF, Southall SM, Wilson JR, Erler JT. The role of lysyl
oxidase in src-dependent proliferation and metastasis of colorectal cancer. J Natl Cancer Inst.
2011;103:407-424
Balani P, Boulaire J, Zhao Y, Zeng J, Lin J, Wang S. High mobility group box2 promoter-controlled suicide gene
expression enables targeted glioblastoma treatment. Mol Ther. 2009;17:1003-1011
Balciunas D, Wangensteen KJ, Wilber A, Bell J, Geurts A, Sivasubbu S, Wang X, Hackett PB, Largaespada DA,
McIvor RS, Ekker SC. Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS
Genet. 2006;2
Balestrieri ML, Lu SJ, de Nigris F, Giovane A, Williams-Ignarro S, D'Armiento FP, Feng Q, Fiorito C, Testa G,
Pastore L, Cacciatore F, Mancini FP, Servillo L, De Rosa G, Pagliarulo C, Rienzo M, Minucci PB, Farzati B,
Salvatore F, Rengo F, Ignarro LJ, Giordano A, Baker A, Lanza R, Napoli C. Therapeutic angiogenesis in diabetic
apolipoprotein e-deficient mice using bone marrow cells, functional hemangioblasts and metabolic intervention.
Atherosclerosis. 2010;209:403-414
Ballatori N, Fang F, Christian W, Li N, Hammond C. Ost {alpha}-ost {beta} is required for bile acid and
conjugated steroid disposition in the intestine, kidney, and liver. American Journal of PhysiologyGastrointestinal and Liver Physiology. 2008;295:G179
Ballatori N, Fang F, Christian WV, Li N, Hammond CL. Ostα-ostβ is required for bile acid and conjugated steroid
disposition in the intestine, kidney, and liver. Am J Physiol Gastrointest Liver Physiol. 2008;295:G179-186
Balzer EM, Whipple RA, Thompson K, Boggs AE, Slovic J, Cho EH, Matrone MA, Yoneda T, Mueller SC, Martin
SS. C-s rc d i fferen t i al l y reg u l at es t h e fu n ct i o n s o f mi cro t en t acl es an d i n v ad o p o d i a. On co g en e.
2010;29:6402-6408
Banaszynski LA, Sellmyer MA, Contag CH, Wandless TJ, Thorne SH. Chemical control of protein stability and
function in living animals. Nature Medicine. 2008;14:1123-1127
Banovic T, MacDonald K, Morris E, Rowe V, Kuns R, Don A, Kelly J, Ledbetter S, Clouston A, Hill G. Tgf-{beta} in
allogeneic stem cell transplantation: Friend or foe? Blood. 2005;106:2206
Banovic T, MacDonald KP, Markey KA, Morris ES, Kuns RD, Varelias A, Hill GR. Donor treatment with a
mu l t i p eg y l at ed g -cs f max i mi zes g raft -v ers u s -l eu k emi a effect s . Bi o l Bl o o d Ma r r o w Tr a n s p l a n t .
2009;15:126-130
Bansal V, Ryu SY, Lopez N, Allexan S, Krzyzaniak M, Eliceiri B, Baird A, Coimbra R. Vagal stimulation
modulates inflammation through a ghrelin mediated mechanism in traumatic brain injury. Inflammation. 2011
Bao L, Gorin MA, Zhang M, Ventura AC, Pomerantz WC, Merajver SD, Teknos TN, Mapp AK, Pan Q. Pre-clinical
development of a bi-functional cancer cell homing, pkcε inhibitory peptide for the treatment of head and neck
cancer. Cancer Res. 2009;69:5829-5834
Bao S, Liu MJ, Lee B, Besecker BY, Lai JP, Guttridge DC, Knoell DL. Zinc modulates the innate immune response
in vivo to polymicrobial sepsis through regulation of nf-{kappa}b. Am J Physiol Lung Cell Mol Physiol. 2010
Bao Y, Peng W, Verbitsky A, Chen J, Wu L, Rauen K, Sawicki J. Human coxsackie adenovirus receptor (car)
expression in transgenic mouse prostate tumors enhances adenoviral delivery of genes. Prostate.
2005;64:401-407
Barak Y, Thorne S, Ackerley D, Lynch S, Contag C, Matin A. New enzyme for reductive cancer chemotherapy, yief,
and its improvement by directed evolution. Mol Cancer Ther. 2006;5:97
Barberi T, Bradbury M, Dincer Z, Panagiotakos G, Socci ND, Studer L. Derivation of engraftable skeletal
myoblasts from human embryonic stem cells. Nat Med. 2007;13:642-648
Barde I, Laurenti E, Verp S, Groner AC, Towne C, Padrun V, Aebischer P, Trumpp A, Trono D. Regulation of
episomal gene expression by krab/kap1-mediated histone modifications. J Virol. 2009
Barendt SM, Land AD, Sham LT, Ng WL, Tsui HC, Arnold RJ, Winkler ME. Influences of capsule on cell shape and
chain formation of wild-type and pcsb mutants of serotype 2 streptococcus pneumoniae. J Bacteriol.
2009;191:3024-3040
Barnes J, Packard A, Zimmerman R, Fahey F, Chaponis D, Treves S, Kieran M. Microspect imaging of tumor
response with the {alpha} v {beta} 3 radiopharmaceutical 99mtc-nc100692. J Nucl Med. 2006;47:175P
115.
116.
117.
118.
119.
120.
121.
122.
123.
124.
125.
126.
127.
128.
129.
130.
131.
132.
133.
134.
135.
136.
137.
Barreiro R, Luker G, Herndon J, Ferguson T. Termination of antigen-specific immunity by cd95 ligand (fas
ligand) and il-10. The Journal of Immunology. 2004;173:1519
Barrett TD, Palomino HL, Brondstetter TI, Kanelakis KC, Wu X, Haug PV, Yan W, Young A, Hua H, Hart JC, Tran
DT, Venkatesan H, Rosen MD, Peltier HM, Sepassi K, Rizzolio MC, Bembenek SD, Mirzadegan T, Rabinowitz MH,
Shankley NP. Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1h-benzoimidazol-2-yl)-1hpyrazole-4-carb oxylic acid (jnj-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase
inhibitor. Molecular pharmacology. 2011;79:910-920
Barth AS, Kizana E, Smith RR, Terrovitis J, Dong P, Leppo MK, Zhang Y, Miake J, Olson EN, Schneider JW,
Abraham MR, Marban E. Lentiviral vectors bearing the cardiac promoter of the na+-ca2+ exchanger report
cardiogenic differentiation in stem cells. Mol Ther. 2008;16:957-964
Bartlett D, Davis M. Effect of sirna nuclease stability on the in vitro and in vivo kinetics of sirna-mediated gene
silencing. Biotechnology and Bioengineering. 2007;97:909-921
Bartlett DW, Davis ME. Insights into the kinetics of sirna-mediated gene silencing from live-cell and live-animal
bioluminescent imaging. Nucleic Acids Res. 2006;34:322-333
Bartlett DW, Su H, Hildebrandt IJ, Weber WA, Davis ME. Impact of tumor-specific targeting on the
biodistribution and efficacy of sirna nanoparticles measured by multimodality in vivo imaging. Proceedings of
the National Academy of Sciences of the United States of America. 2007;104:15549-15554
Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Soballe K, Nishio Y, Drissi MH, Langstein HN,
Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA. Freeze-dried tendon allografts as tissue-engineering scaffolds for
gdf5 gene delivery. Mol Ther. 2008;16:466-473
Basseres DS, Ebbs A, Levantini E, Baldwin AS. Requirement of the nf-kappab subunit p65/rela for k-ras-induced
lung tumorigenesis. Cancer Res. 2010;70:3537-3546
Bastianutto C, Mian A, Symes J, Mocanu J, Alajez N, Sleep G, Shi W, Keating A, Crump M, Gospodarowicz M,
Medin J, Minden M, Liu FF. Local radiotherapy induces homing of hematopoietic stem cells to the irradiated
bone marrow. Cancer Res. 2007;67:10112-10116
Battula V, Evans K, Hollier B, Shi Y, Marini F, Ayyanan A, Wang R, Brisken C, Guerra R, Andreeff M. Epithelial
mesenchymal transition derived cells exhibit multi lineage differentiation potential similar to mesenchymal
stem cells. Stem Cells. 2010;28:1435-1445
Bauerschmitz G, Guse K, Kanerva A, Menzel A, Herrmann I, Desmond R, Yamamoto M, Nettelbeck D, Hakkarainen
T, Dall P. Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, e1a transcomplementation, and
serotype chimerism for enhanced selectivity for ovarian cancer cells. Molecular Therapy. 2006;14:164-174
Baughn LB, Di Liberto M, Wu K, Toogood PL, Louie T, Gottschalk R, Niesvizky R, Cho H, Ely S, Moore MA,
Chen-Kiang S. A novel orally active small molecule potently induces g1 arrest in primary myeloma cells and
prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6. Cancer Res. 2006;66:7661-7667
Baumes JM, Gassensmith JJ, Giblin J, Lee JJ, White AG, Culligan WJ, Leevy WM, Kuno M, Smith BD. Storable,
thermally activated, near-infrared chemiluminescent dyes and dye-stained microparticles for optical imaging.
Nat Chem. 2010;2:1025-1030
Bayer M, Kantor B, Cockrell A, Ma H, Zeithaml B, Li X, McCown T, Kafri T. A large u3 deletion causes increased in
vivo expression from a nonintegrating lentiviral vector. Mol Ther. 2008;16:1968-1976
Bayo-Puxan N, Cascallo M, Gros A, Huch M, Fillat C, Alemany R. Role of the putative heparan sulfate
glycosaminoglycan-binding site of the adenovirus type 5 fiber shaft on liver detargeting and knob-mediated
retargeting. Journal of General Virology. 2006;87:2487
Becher OJ, Hambardzumyan D, Fomchenko EI, Momota H, Mainwaring L, Bleau AM, Katz AM, Edgar M, Kenney
AM, Cordon-Cardo C, Blasberg RG, Holland EC. Gli activity correlates with tumor grade in platelet-derived
growth factor-induced gliomas. Cancer Res. 2008;68:2241-2249
Beck BH, Kim HG, Kim H, Samuel S, Liu Z, Shrestha R, Haines H, Zinn K, Lopez RD. Adoptively transferred ex
vivo expanded gammadelta-t cells mediate in vivo antitumor activity in preclinical mouse models of breast
cancer. Breast Cancer Res Treat. 2009
Becker CM, Wright RD, Satchi-Fainaro R, Funakoshi T, Folkman J, Kung AL, D’Amato RJ. A novel noninvasive
model of endometriosis for monitoring the efficacy of antiangiogenic therapy. American Journal of Pathology.
2006;168:2074-2084
Begley M, Bron PA, Heuston S, Casey PG, Englert N, Wiesner J, Jomaa H, Gahan CGM, Hill C. Analysis of the
isoprenoid biosynthesis pathways in listeria monocytogenes reveals a role for the alternative 2-c-methyl-derythritol 4-phosphate pathway in murine infection▿. Infection and Immunity. 2008;76:5392-5401
Begley M, Kerr C, Hill C. Exposure to bile influences biofilm formation by listeria monocytogenes. Gut Pathog.
2009;1:11
Beilhack A, Schulz S, Baker J, Beilhack GF, Nishimura R, Baker EM, Landan G, Herman EI, Butcher EC, Contag
CH, Negrin RS. Prevention of acute graft-versus-host disease by blocking t-cell entry to secondary lymphoid
organs. Blood. 2008;111:2919-2928
Beilhack A, Schulz S, Baker J, Beilhack GF, Wieland CB, Herman EI, Baker EM, Cao Y-A, Contag CH, Negrin RS.
In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of t-cell subsets.
Blood. 2005;106:1113-1122
Beilke J, Edwards L, Gill R. Nk cells restrain cd8 t cells during tolerance induction to islet allografts.
Transplantation. 2006;82:367
138.
139.
140.
141.
142.
143.
144.
145.
146.
147.
148.
149.
150.
151.
152.
153.
154.
155.
156.
157.
158.
159.
160.
Beksac M, Kuzu I, Ozdemir M, Ayten M, Dalva K, Ucnullkan D, Kilicnull E, Attar A, Kanpolat Y. Tracking of donor
type gren fluorescent and luciferase positive marrow mononuclear or mesenchymal stem cells in postmortem
spinal cord histopathological sections for determination of regeneration in a spinal cord injury model.
Haematologica. 2009;94:66
Bell J, Aronovich E, Koniar B, Schreifels J, Clifford A, Hoekstra N, Hackett P. Duration of expression of the
sleeping beauty transposase gene in mouse liver following hydrodynamic delivery&ast. Molecular Therapy.
2006;13:S150
Bell JB, Aronovich EL, Schreifels JM, Beadnell TC, Hackett PB. Duration of expression and activity of sleeping
beauty transposase in mouse liver following hydrodynamic DNA delivery. Mol Ther. 2010
Bell JB, Podetz-Pedersen KM, Aronovich EL, Belur LR, McIvor RS, Hackett PB. Preferential delivery of the
sleeping beauty transposon system to livers of mice by hydrodynamic injection. Nat Protoc. 2007;2:3153-3165
Bellinger-Kawahara CG, Francis KP, Larkin A, Winterberg PD, Sin LV. Bioluminescent monitoring of drug
efficacy in a six-hour murine sepsis model. Abstracts of the General Meeting of the American Society for
Microbiology. 2002;102:162
Bellinger-Kawahara CG, Francis KP, Purchio AF, Contag PR. Bioluminescent monitoring of disease progression
in a mouse model of pneumonia. Abstracts of the General Meeting of the American Society for Microbiology.
2001;101:293
Bellinger-Kawahara CG, Sin LV, Larkin A, Pardi D, Tomkiel D, Winterberg PD. Evidence of early spread and
invasion in a bioluminescent model of pneumonia caused by yersinia pseudotuberculosis. Abstracts of the
General Meeting of the American Society for Microbiology. 2002;102:174
Bellinger-Kawahara CG, Winterberg PD, Francis KP, Sin LV, Larkin A. A bioluminescent model of murine
pneumonia caused by pseudomonas aeruginosa. Abstracts of the General Meeting of the American Society for
Microbiology. 2002;102:171
Bellis AD, Penalver-Bernabe B, Weiss MS, Yarrington ME, Barbolina MV, Pannier AK, Jeruss JS, Broadbelt LJ,
Shea LD. Cellular arrays for large-scale analysis of transcription factor activity. Biotechnology and
bioengineering. 2011;108:395-403
Belur L, Buske T, Sorensen B, Podetz-Peterson K, Saltzman D, Hackett P, McIvor R. Sleeping beauty-mediated
gene therapy for colorectal cancer. Molecular Therapy. 2006;13:S369
Belur LR, Fairbanks C, Vulchanova L, Schuster D, Riedl M, Podetz-Pedersen K, Kitto KF, McIvor RS. Intrathecal
delivery of the sleeping beauty transposon system for treatment of chronic pain. Molecular Therapy.
2009;17:S358
Belur LR, McIvor RS, Wilber A. Liver-directed gene therapy using the sleeping beauty transposon system.
Methods Mol Biol. 2008;434:267-276
Belur LR, Podetz-Pedersen K, Frandsen J, McIvor RS. Lung-directed gene therapy in mice using the nonviral
sleeping beauty transposon system. Nat Protoc. 2007;2:3146-3152
Benaron D. The future of cancer imaging. Cancer and Metastasis Reviews. 2002;21:45-78
Benaron DA, Contag PR, Contag CH. Imaging brain structure and function, infection and gene expression in the
body using light. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.
1997;352:755-761
Beraza N, Marqués J, Martínez Ansó E, Iñiguez M, Prieto J, Bustos M. Interplay among cardiotrophin 1,
prostaglandins, and vascular endothelial growth factor in rat liver regeneration. Hepatology. 2005;41:460-469
Berger F, Paulmurugan R, Bhaumik S, Gambhir SS. Uptake kinetics and biodistribution of 14c-d-luciferin--a
radiolabeled substrate for the firefly luciferase catalyzed bioluminescence reaction: Impact on bioluminescence
b as ed rep o rt er g en e i mag i n g . Eu r o p ea n j o u r n a l o f n u cl ea r med i ci n e a n d mo l ecu l a r i ma g i n g .
2008;35:2275-2285
Berger M, Krebs P, Crozat K, Li X, Croker BA, Siggs OM, Popkin D, Du X, Lawson BR, Theofilopoulos AN, Xia Y,
Khovananth K, Moresco EMY, Satoh T, Takeuchi O, Akira S, Beutler B. A slfn2 mutation causes lymphoid and
myeloid immunodeficiency due to loss of immune cell quiescence. Nat Immunol. 2010;11:335-343
Bergstrom KS, Guttman JA, Rumi M, Ma C, Bouzari S, Khan MA, Gibson DL, Vogl AW, Vallance BA. Modulation
of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen. Infect Immun.
2008;76:796-811
Bergstrom KSB, Kissoon-Singh V, Gibson DL, Ma C, Montero M, Sham HP, Ryz N, Huang T, Velcich A, Finlay BB,
Chadee K, Vallance BA. Muc2 protects against lethal infectious colitis by disassociating pathogenic and
commensal bacteria from the colonic mucosa. PLoS Pathog. 2010;6
Berman SC, Galpoththawela C, Gilad AA, Bulte JW, Walczak P. Long-term mr cell tracking of neural stem cells
grafted in immunocompetent versus immunodeficient mice reveals distinct differences in contrast between live
and dead cells. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in
Medicine / Society of Magnetic Resonance in Medicine. 2011;65:564-574
Bernthal NM, Pribaz JR, Stavrakis AI, Billi F, Cho JS, Ramos RI, Francis KP, Iwakura Y, Miller LS. Protective role
of il-1beta against post-arthroplasty staphylococcus aureus infection. Journal of orthopaedic research : official
publication of the Orthopaedic Research Society. 2011
Bernthal NM, Stavrakis AI, Billi F, Cho JS, Kremen TJ, Simon SI, Cheung AL, Finerman GA, Lieberman JR, Adams
JS, Miller LS. A mouse model of post-arthroplasty staphylococcus aureus joint infection to evaluate in vivo the
efficacy of antimicrobial implant coatings. PLoS One. 2010;5
161.
162.
163.
164.
165.
166.
167.
168.
169.
170.
171.
172.
173.
174.
175.
176.
177.
178.
179.
180.
181.
182.
183.
184.
185.
Berraondo P, Crettaz J, Ochoa L, Pañeda A, Prieto J, Trocóniz I, González-Aseguinolaza G. Intrahepatic injection
of recombinant adeno-associated virus serotype 2 overcomes gender-related differences in liver transduction.
Human Gene Therapy. 2006;17:601-610
Berraondo P, González-Aseguinolaza G, Trocóniz I. Semi-mechanistic pharmacodynamic modelling of gene
expression and silencing processes. European Journal of Pharmaceutical Sciences. 2009;37:418-426
Bertino P, Piccardi F, Porta C, Favoni R, Cilli M, Mutti L, Gaudino G. Imatinib mesylate enhances therapeutic
effects of gemcitabine in human malignant mesothelioma xenografts. Clin Cancer Res. 2008;14:541-548
Bertoni C, Jarrahian S, Wheeler TM, Li Y, Olivares EC, Calos MP, Rando TA. Enhancement of plasmid-mediated
gene therapy for muscular dystrophy by directed plasmid integration. Proceedings of the National Academy of
Sciences of the United States of America. 2006;103:419-424
Best SR, Peng S, Juang CM, Hung CF, Hannaman D, Saunders JR, Wu TC, Pai SI. Administration of hpv DNA
vaccine via electroporation elicits the strongest cd8+ t cell immune responses compared to intramuscular
injection and intradermal gene gun delivery. Vaccine. 2009;27:5450-5459
Betigeri S, Zhang M, Garbuzenko O, Minko T. Non-viral systemic delivery of sirna or antisense oligonucleotides
targeted to jun n-terminal kinase 1 prevents cellular hypoxic damage. Drug delivery and translational research.
2011;1:13-24
Bhaumik S, Gambhir SS. Optical imaging of renilla luciferase reporter gene expression in living mice.
Proceedings of the National Academy of Sciences of the United States of America. 2002;99:377-382
Bhaumik S, Walls Z, Puttaraju M, Mitchell LG, Gambhir SS. Molecular imaging of gene expression in living
subjects by spliceosome-mediated rna trans-splicing. Proceedings of the National Academy of Sciences of the
United States of America. 2004;101:8693-8698
Bhowmick N, Chytil A, Plieth D, Gorska A, Dumont N, Shappell S, Washington M, Neilson E, Moses H. Tgf-{beta}
signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science. 2004;303:848
Billingsley K, Balaconis MK, Dubach JM, Zhang N, Lim E, Francis KP, Clark HA. Fluorescent nano-optodes for
glucose detection. Anal Chem. 2010;82:3707-3713
Bina XR, Miller MA, Bina JE. Construction of a bioluminescence reporter plasmid for francisella tularensis.
Plasmid. 2010;64:156-161
Bins A, Wolkers M, van den Boom M, Haanen J, Schumacher T. In vivo antigen stability affects DNA vaccine
immunogenicity. The Journal of Immunology. 2007;179:2126
Bins AD, Jorritsma A, Wolkers MC, Hung CF, Wu TC, Schumacher TN, Haanen JB. A rapid and potent DNA
vaccination strategy defined by in vivo monitoring of antigen expression. Nat Med. 2005;11:899-904
Birsoy K, Soukas A, Torrens J, Ceccarini G, Montez J, Maffei M, Cohen P, Fayzikhodjaeva G, Viale A, Socci ND,
Friedman JM. Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach.
Proceedings of the National Academy of Sciences of the United States of America. 2008;105:12985-12990
Bisanz K, Yu J, Edlund M, Spohn B, Hung MC, Chung LW, Hsieh CL. Targeting ecm-integrin interaction with
liposome-encapsulated small interfering rnas inhibits the growth of human prostate cancer in a bone xenograft
imaging model. Mol Ther. 2005;12:634-643
Bishop A, Wiles S, Dougan G, Frankel G. Cell attachment properties and infectivity of host-adapted and
environmentally adapted citrobacter rodentium. Microbes and Infection. 2007;9:1316-1324
Bisland S, Chien C, Wilson B, Burch S. Pre-clinical in vitro and in vivo studies to examine the potential use of
photodynamic therapy in the treatment of osteomyelitis. Photochemical & Photobiological Sciences.
2006;5:31-38
Bisland SK, Johnson C, Diab M, Wilson BC, Burch S. A new technique for physiodesis using photodynamic
therapy. Clin Orthop Relat Res. 2007;461:153-161
Biswas S, Guix M, Rinehart C, Dugger TC, Chytil A, Moses HL, Freeman ML, Arteaga CL. Inhibition of tgf-beta
with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J Clin
Invest. 2007;117:1305-1313
Biswas S, Roy S, Banerjee J, Hussain SRA, Khanna S, Meenakshisundaram G, Kuppusamy P, Friedman A, Sen CK.
Hypoxia inducible microrna 210 attenuates keratinocyte proliferation and impairs closure in a murine model of
ischemic wounds. Proceedings of the National Academy of Sciences of the United States of America.
2010;107:6976-6981
BitMansour A, Burns SM, Traver D, Akashi K, Contag CH, Weissman IL, Brown JM. Myeloid progenitors protect
against invasive aspergillosis and pseudomonas aeruginosa infection following hematopoietic stem cell
transplantation. Blood. 2002;100:4660-4667
Bivas-Benita M, Bar L, Gillard G, Kaufman D, Simmons N, Hovav A, Letvin N. Efficient generation of mucosal and
systemic antigen-specific cd8+ t-cell responses following pulmonary DNA immunization. J Virol. 2010;84:5764
Bjorndahl MA, Cao R, Burton JB, Brakenhielm E, Religa P, Galter D, Wu L, Cao Y. Vascular endothelial growth
factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis. Cancer Res. 2005;65:9261-9268
Black KL, Yin D, Ong JM, Hu J, Konda BM, Wang X, Ko MK, Bayan JA, Sacapano MR, Espinoza A, Morris-Irvin
DK, Shu Y. Pde5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model.
Brain Research. 2008;1230:290-302
Black P, Shetty A, Brown G, Esparza Coss E, Metwalli A, Agarwal P, McConkey D, Hazle J, Dinney C. Validating
bladder cancer xenograft bioluminescence with magnetic resonance imaging: The significance of hypoxia and
necrosis. BJU International. 2010
186.
187.
188.
189.
190.
191.
192.
193.
194.
195.
196.
197.
198.
199.
200.
201.
202.
203.
204.
205.
206.
207.
208.
209.
210.
Blanco MA, Aleckovic M, Hua Y, Li T, Wei Y, Xu Z, Cristea IM, Kang Y. Identification of staphylococcal nuclease
domain-containing 1 (snd1) as a metadherin-interacting protein with metastasis-promoting functions. The
Journal of biological chemistry. 2011;286:19982-19992
Blankenberg FG, Mandl S, Cao YA, O'Connell-Rodwell C, Contag C, Mari C, Gaynutdinov TI, Vanderheyden JL,
Backer MV, Backer JM. Tumor imaging using a standardized radiolabeled adapter protein docked to vascular
endothelial growth factor. The Journal of Nuclear Medicine. 2004;45:1373-1380
Blasberg RG. In vivo molecular-genetic imaging: Multi-modality nuclear and optical combinations. Nuclear
Medicine and Biology. 2003;30:879-888
Blomeier H, Zhang X, Rives C, Brissova M, Hughes E, Baker M, Powers AC, Kaufman DB, Shea LD, Lowe WL.
Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation. Transplantation.
2006;82:452-459
Blum G, von Degenfeld G, Merchant MJ, Blau HM, Bogyo M. Noninvasive optical imaging of cysteine protease
activity using fluorescently quenched activity-based probes. Nat Chem Biol. 2007;3:668-677
Boddington S, Sutton E, Jones E, Purcell D, Henning T, Tavri S, Meier R, Sista A, Fu Y, Daldrup-Link H. Improved
fluorescence of indocyanine green in vitro and in vivo after simple cooling procedures. Contrast Media &
Molecular Imaging. 2008;3:191-197
Boddington SE, Henning TD, Jha P, Schlieve CR, Mandrussow L, DeNardo D, Bernstein HS, Ritner C, Golovko D,
Lu Y, Zhao S, Daldrup-Link HE. Labeling human embryonic stem cell-derived cardiomyocytes with indocyanine
green for noninvasive tracking with optical imaging: An fda-compatible alternative to firefly luciferase. Cell
Transplant. 2010;19:55-65
Boddington SE, Sutton EJ, Henning TD, Nedopil AJ, Sennino B, Kim A, Daldrup-Link HE. Labeling human
mesenchymal stem cells with fluorescent contrast agents: The biological impact. Molecular imaging and
biology : MIB : the official publication of the Academy of Molecular Imaging. 2011;13:3-9
Boerckel JD, Kolambkar YM, Dupont KM, Uhrig BA, Phelps EA, Stevens HY, Garcia AJ, Guldberg RE. Effects of
protein dose and delivery system on bmp-mediated bone regeneration. Biomaterials. 2011;32:5241-5251
Bogdanov AA, Jr., Lin CP, Kang HW. Optical imaging of the adoptive transfer of human endothelial cells in mice
using anti-human cd31 monoclonal antibody. Pharm Res. 2007;24:1186-1192
Bom H, Min J, Jeong H. Molecular nuclear imaging for targeting and trafficking. NUCLEAR ENGINEERING AND
TECHNOLOGY. 2006;38:399
Bondareva A, Downey CM, Ayres F, Liu W, Boyd SK, Hallgrimsson B, Jirik FR. The lysyl oxidase inhibitor, betaaminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells. PLoS One.
2009;4:e5620
Bopp SER, Ramachandran V, Henson K, Luzader A, Lindstrom M, Spooner M, Steffy BM, Suzuki O, Janse C,
Waters AP, Zhou Y, Wiltshire T, Winzeler EA. Genome wide analysis of inbred mouse lines identifies a locus
containing ppar-γ as contributing to enhanced malaria survival. PLoS One. 2010;5
Borghei A, Ouyang YB, Westmuckett AD, Marcello MR, Landel CP, Evans JP, Moore KL. Targeted disruption of
tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine o-sulfation,
causes male infertility. Journal of Biological Chemistry. 2006;281:9423-9431
Borlee BR, Geske GD, Robinson CJ, Blackwell HE, Handelsman J. Quorum-sensing signals in the microbial
community of the cabbage white butterfly larval midgut. Isme J. 2008;2:1101-1111
Bortolanza S, Bunuales M, Alzuguren P, Lamas O, Aldabe R, Prieto J, Hernandez-Alcoceba R. Deletion of the
e3-6.7 k/gp19k region reduces the persistence of wild-type adenovirus in a permissive tumor model in syrian
hamsters. Cancer Gene Therapy. 2009;16:703-712
Bortolanza S, Bunuales M, Otano I, Gonzalez-Aseguinolaza G, Ortiz-de-Solorzano C, Perez D, Prieto J, HernandezAlcoceba R. Treatment of pancreatic cancer with an oncolytic adenovirus expressing interleukin-12 in syrian
hamsters. Mol Ther. 2009;17:614-622
Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA,
Massague J. Genes that mediate breast cancer metastasis to the brain. Nature. 2009;459:1005-1009
Boschi F, Calderan L, D'Ambrosio D, Marengo M, Fenzi A, Calandrino R, Sbarbati A, A ES. In vivo (1)f-fdg
tumour uptake measurements in small animals using cerenkov radiation. European journal of nuclear medicine
and molecular imaging. 2011;38:120-127
Boschi F, Spinelli AE, D'Ambrosio D, Calderan L, Marengo M, Sbarbati A. Combined optical and single photon
emission imaging: Preliminary results. Physics in Medicine and Biology. 2009;54:L57-62
Boudakov I, Liu J, Fan N, Gulay P, Wong K, Gorczynski R. Mice lacking cd200r1 show absence of suppression of
lipopolysaccharide-induced tumor necrosis factor-[alpha] and mixed leukocyte culture responses by cd200.
Transplantation. 2007;84:251
Boudreau RL, Monteys AM, Davidson BL. Minimizing variables among hairpin-based rnai vectors reveals the
potency of shrnas. RNA. 2008;14:1834-1844
Boulos N, Mulder HL, Calabrese CR, Morrison JB, Rehg JE, Relling MV, Sherr CJ, Williams RT.
Chemotherapeutic agents circumvent emergence of dasatinib-resistant bcr-abl kinase mutations in a precise
mouse model of philadelphia chromosome-positive acute lymphoblastic leukemia. Blood. 2011;117:3585-3595
Boutte AM, Friedman DB, Bogyo M, Min Y, Yang L, Lin PC. Identification of a myeloid-derived suppressor cell
cystatin-like protein that inhibits metastasis. Faseb J. 2011;25:2626-2637
Bowen EJ, Schmidt TW, Firm CS, Russo AF, Durham PL. Tumor necrosis factor-α stimulation of calcitonin gene-
211.
212.
213.
214.
215.
216.
217.
218.
219.
220.
221.
222.
223.
224.
225.
226.
227.
228.
229.
230.
231.
232.
233.
234.
235.
related peptide expression and secretion from rat trigeminal ganglion neurons. Journal of Neurochemistry.
2006;96:65-77
Bowman P, Bynum J, Kiang JG, Baer D, Johnson J, Dubick M. Noninvasive imaging of hemorrhage-induced
global ischemia with a transgenic mouse expressing luciferase coupled to hypoxia-inducible factor (hif1(alpha)).
The FASEB Journal. 2009;23
Boyle JP, Saeij JP, Boothroyd JC. Toxoplasma gondii: Inconsistent dissemination patterns following oral
infection in mice. Exp Parasitol. 2007
Bradbury MS, Tomishima M, Panagiotakos G, Chan BK, Zanzonico P, Vider J, Ponomarev V, Studer L, Tabar V.
Optical bioluminescence imaging of human es cell progeny in the rodent cns. J Neurochem. 2007
Brader P, Riedl CC, Woo Y, Ponomarev V, Zanzonico P, Wen B, Cai S, Hricak H, Fong Y, Blasberg R, Serganova I.
Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model. Mol Cancer Ther.
2007;6:2900-2908
Brader P, Stritzker J, Riedl CC, Zanzonico P, Cai S, Burnazi EM, Ghani ER, Hricak H, Szalay AA, Fong Y, Blasberg
R. Escherichia coli nissle 1917 facilitates tumor detection by positron emission tomography and optical
imaging. Clin Cancer Res. 2008
Brakenhielm E, Burton JB, Johnson M, Chavarria N, Morizono K, Chen I, Alitalo K, Wu L. Modulating metastasis
by a lymphangiogenic switch in prostate cancer. International Journal of Cancer. 2007;121:2153-2161
Bralten LB, Kloosterhof NK, Balvers R, Sacchetti A, Lapre L, Lamfers M, Leenstra S, de Jonge H, Kros JM, Jansen
EE, Struys EA, Jakobs C, Salomons GS, Diks SH, Peppelenbosch M, Kremer A, Hoogenraad CC, Smitt PA, French
PJ. Idh1 r132h decreases proliferation of glioma cell lines in vitro and in vivo. Annals of neurology.
2011;69:455-463
Brand AM, de Kwaadsteniet M, Dicks LM. The ability of nisin f to control staphylococcus aureus infection in the
peritoneal cavity, as studied in mice. Lett Appl Microbiol. 2010;51:645-649
Brandl K, Plitas G, Schnabl B, DeMatteo RP, Pamer EG. Myd88-mediated signals induce the bactericidal lectin
regiii gamma and protect mice against intestinal listeria monocytogenes infection. J Exp Med.
2007;204:1891-1900
Bratlie KM, Dang TT, Lyle S, Nahrendorf M, Weissleder R, Langer R, Anderson DG. Rapid biocompatibility
analysis of materials via in vivo fluorescence imaging of mouse models. PLoS One. 2010;5
Braunreiter C, Hancock J, Coffin C, Boucher K, Lessnick S. Expression of ews-ets fusions in nih3t3 cells reveals
significant differences to ewing’s sarcoma. Cell Cycle. 2006;5:2753-2759
Bray I, Tivnan A, Bryan K, Foley NH, Watters KM, Tracey L, Davidoff AM, Stallings RL. Microrna-542-5p as a
novel tumor suppressor in neuroblastoma. Cancer letters. 2011;303:56-64
Breitbach CJ, Paterson JM, Lemay CG, Falls TJ, McGuire A, Parato KA, Stojdl DF, Daneshmand M, Speth K, Kirn
D, McCart JA, Atkins H, Bell JC. Targeted inflammation during oncolytic virus therapy severely compromises
tumor blood flow. Mol Ther. 2007;15:1686-1693
Breitmeyer J, Campbell M, Allan B, Marquis D, Ondek B, Watkins J. Ame-133: A next-generation anti-cd20
engineered for enhanced killer function. Journal of Immunotherapy. 2004;27:S52
Bremer E, van Dam GM, de Bruyn M, van Riezen M, Dijkstra M, Kamps G, Helfrich W, Haisma H. Potent systemic
anticancer activity of adenovirally expressed egfr-selective trail fusion protein. Mol Ther. 2008;16:1919-1926
Brentjens RJ, Santos E, Nikhamin Y, Yeh R, Matsushita M, La Perle K, Quintas-Cardama A, Larson SM, Sadelain
M. Genetically targeted t cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin Cancer Res.
2007;13:5426-5435
Breous E, Somanathan S, Vandenberghe LH, Wilson JM. Hepatic regulatory t cells and kupffer cells are crucial
mediators of systemic t cell tolerance to antigens targeting murine liver. Hepatology. 2009;50:612-621
Briat A, Vassaux G. A new transgenic mouse line to image chemically induced p53 activation in vivo. Cancer Sci.
2008;99:683-688
Brock M, Jouvion G, Droin-Bergere S, Dussurget O, Nicola MA, Ibrahim-Granet O. Bioluminescent aspergillus
fumigatus, a new tool for drug efficiency testing and in vivo monitoring of invasive aspergillosis. Appl Environ
Microbiol. 2008;74:7023-7035
Brody JD, Goldstein MJ, Czerwinski DK, Levy R. Immunotransplantation preferentially expands t-effector cells
over t-regulatory cells and cures large lymphoma tumors. Blood. 2009;113:85-94
Broggini-Tenzer A, Vuong V, Pruschy M. Metabolism of tumors under treatment: Mapping of metabolites with
quantitative bioluminescence. Radiotherapy and oncology : journal of the European Society for Therapeutic
Radiology and Oncology. 2011;99:398-403
Bron PA, Monk IR, Corr SC, Hill C, Gahan CGM. Novel luciferase reporter system for in vitro and organ-specific
monitoring of differential gene expression in listeria monocytogenes. Applied and Environmental Microbiology.
2006;72:2876-2884
Brown C, Wright C, Naranjo A, Vishwanath R, Chang W, Olivares S, Wagner J, Bruins L, Raubitschek A, Cooper L.
Biophotonic cytotoxicity assay for high-throughput screening of cytolytic killing. Journal of Immunological
Methods. 2005;297:39-52
Brown CE, Vishwanath RP, Aguilar B, Starr R, Najbauer J, Aboody KS, Jensen MC. Tumor-derived chemokine
mcp-1/ccl2 is sufficient for mediating tumor tropism of adoptively transferred t cells. J Immunol.
2007;179:3332-3341
Brown D, Synold T, Kane S. In vivo imaging of mdr1a gene expression. Proceedings of the American Association
236.
237.
238.
239.
240.
241.
242.
243.
244.
245.
246.
247.
248.
249.
250.
251.
252.
253.
254.
255.
256.
257.
258.
259.
for Cancer Research. 2005;2005:123
Brown KV, Walker JA, Cortez DS, Murray CK, Wenke JC. Earlier debridement and antibiotic administration
decrease infection. Journal of surgical orthopaedic advances. 2010;19:18-22
Bruggink JL, Meerwaldt R, van Dam GM, Lefrandt JD, Slart RH, Tio RA, Smit AJ, Zeebregts CJ. Spectroscopy to
improve identification of vulnerable plaques in cardiovascular disease. Int J Cardiovasc Imaging.
2010;26:111-119
Brusko TM, Koya RC, Zhu S, Lee MR, Putnam AL, McClymont SA, Nishimura MI, Han S, Chang LJ, Atkinson MA,
Ribas A, Bluestone JA. Human antigen-specific regulatory t cells generated by t cell receptor gene transfer. PLoS
One. 2010;5
Bryant MJ, Chuah TL, Luff J, Lavin MF, Walker DG. A novel rat model for glioblastoma multiforme using a
bioluminescent f98 cell line. J Clin Neurosci. 2008;15:545-551
Bryant N, Gillespie G, Lopez R, Markert J, Cloud G, Langford C, Arnouk H, Su Y, Haines H, Suarez-Cuervo C.
Preclinical evaluation of ex vivo expanded/activated t cells for immunotherapy of glioblastoma multiforme.
Journal of Neuro-Oncology. 2011;101:179-188
Brynskikh AM, Zhao Y, Mosley RL, Li S, Boska MD, Klyachko NL, Kabanov AV, Gendelman HE, Batrakova EV.
Macrophage delivery of therapeutic nanozymes in a murine model of parkinson’s disease. Nanomedicine (Lond).
2010;5:379-396
Bucher C, Zhou J, Mondale H, Johnson M, Liu L, Vogtenhuber C, Lees C, Iwakura Y, Vallera DA, Weigel B, Blazar
BR. Treg depletion with interleukin-2-diphteriatoxin (il-2dt) is sufficient to induce tumor clearance in acute
myeloid leukemia (aml). Blood. 2008;112:1014-1015
Buckley SM, Howe SJ, Sheard V, Ward NJ, Coutelle C, Thrasher AJ, Waddington SN, McKay TR. Lentiviral
transduction of the murine lung provides efficient pseudotype and developmental stage-dependent cell-specific
transgene expression. Gene Ther. 2008;15:1167-1175
Buhles A, Collins SA, van Pijkeren JP, Rajendran S, Miles M, O'Sullivan GC, O'Hanlon DM, Tangney M. Antimetastatic effects of viral and non-viral mediated nk4 delivery to tumours. Genet Vaccines Ther. 2009;7:5
Buijs JT, Henriquez NV, van Overveld PG, van der Horst G, Que I, Schwaninger R, Rentsch C, Ten Dijke P, CletonJansen AM, Driouch K, Lidereau R, Bachelier R, Vukicevic S, Clezardin P, Papapoulos SE, Cecchini MG, Lowik
CW, van der Pluijm G. Bone morphogenetic protein 7 in the development and treatment of bone metastases from
breast cancer. Cancer Res. 2007;67:8742-8751
Bullain SS, Sahin A, Szentirmai O, Sanchez C, Lin N, Baratta E, Waterman P, Weissleder R, Mulligan RC, Carter
BS. Genetically engineered t cells to target egfrviii expressing glioblastoma. Journal of Neuro-Oncology.
2009;94:373-382
Bullok K, Maxwell D, Kesarwala A, Gammon S, Prior J, Snow M, Stanley S, Piwnica-Worms D. Biochemical and in
vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging
apoptosis†. Biochemistry. 2007;46:4055-4065
Bunuales M, Duzgunes N, Zalba S, Garrido MJ, de Ilarduya CT. Efficient gene delivery by egf-lipoplexes in vitro
and in vivo. Nanomedicine : nanotechnology, biology, and medicine. 2011;6:89-98
Burch S, Bisland S, Bogaards A, Yee A, Whyne C, Finkelstein J, Wilson B. Photodynamic therapy for the
treatment of vertebral metastases in a rat model of human breast carcinoma. Journal of Orthopaedic Research.
2005;23:995-1003
Burch S, Bisland S, Wilson B, Whyne C, Finkelstein J, Chow E, Yee A. Photodynamic therapy for the treatment of
spinal metasteses: Studies in rat and porcine models. Journal of Bone and Joint Surgery - British.
2008;90:71-72
Burch S, Bisland S, Wilson B, Whyne C, Yee A. Multimodality imaging for vertebral metastases in a rat osteolytic
model. Clinical Orthopaedics and Related Research. 2007;454:230
Burgos JS. Noninvasive bioluminescent imaging of infections. Methods Mol Biol. 2009;574:115-124
Burgos JS, Guzman-Sanchez F, Sastre I, Fillat C, Valdivieso F. Non-invasive bioluminescence imaging for
monitoring herpes simplex virus type 1 hematogenous infection. Microbes and Infection. 2006;8:1330-1338
Burgos JS, Rosol M, Moats RA, Khankaldyyan V, Kohn DB, Nelson MD, Jr., Laug WE. Time course of
bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice. Biotechniques.
2003;34:1184-1188
Burk LM, Lee YZ, Heathcote S, Wang K-h, Kim WY, Lu J, Zhou O. Carbon nanotube based respiratory gated
micro-ct imaging of a murine model of lung tumors with optical imaging correlation. SPIE; 2011.
Burkatovskaya M, Castano AP, Demidova-Rice TN, Tegos GP, Hamblin MR. Effect of chitosan acetate bandage on
wound healing in infected and noninfected wounds in mice. Wound Repair and Regeneration. 2008;16:425-431
Burkatovskaya M, Tegos GP, Swietlik E, Demidova TN, Castano AP, Hamblin MR. Use of chitosan bandage to
p rev en t fat al i n fect i o n s d ev el o p i n g fro m h i g h l y co n t ami n at ed wo u n d s i n mi ce. Bi o ma t er i a l s .
2006;27:4157-4164
Burke CW, Mason JN, Surman SL, Jones BG, Dalloneau E, Hurwitz JL, Russell CJ. Illumination of parainfluenza
virus infection and transmission in living animals reveals a tissue-specific dichotomy. PLoS pathogens.
2011;7:e1002134
Burns SM, Joh D, Francis KP, Shortliffe LD, Gruber CA, Contag PR, Contag CH. Revealing the spatiotemporal
patterns of bacterial infectious diseases using bioluminescent pathogens and whole body imaging.
Contributions to Microbiology. 2001;9:71-88
260.
261.
262.
263.
264.
265.
266.
267.
268.
269.
270.
271.
272.
273.
274.
275.
276.
277.
278.
279.
280.
281.
282.
283.
Burns SM, Olomu IN, Zhao H, Wong RJ, Stevenson DK, Contag CH. Monitoring age-related susceptibility of
young mice to oral salmonella enterica serovar typhimurium infection using an in vivo murine model. Pediatric
Research. 2005
Burton CM, Iversen M, Carlsen J, Andersen CB. Interstitial inflammatory lesions of the pulmonary allograft: A
retrospective analysis of 2697 transbronchial biopsies. Transplantation. 2008;86:811-819
Burton JB, Johnson M, Sato M, Koh SBS, Mulholland DJ, Stout D, Chatziioannou AF, Phelps ME, Wu H, Wu L.
Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate
cancer. Nature Medicine. 2008;14:882-888
Buschow C, Charo J, Anders K, Loddenkemper C, Jukica A, Alsamah W, Perez C, Willimsky G, Blankenstein T. In
vivo imaging of an inducible oncogenic tumor antigen visualizes tumor progression and predicts ctl tolerance. J
Immunol. 2010;184:2930-2938
Butoescu N, Seemayer CA, Palmer G, Guerne PA, Gabay C, Doelker E, Jordan O. Magnetically retainable
microparticles for drug delivery to the joint: Efficacy studies in an antigen-induced arthritis model in mice.
Arthritis Res Ther. 2009;11:R72
Butterworth KT, McCarthy HO, Devlin A, Ming L, Robson T, McKeown SR, Worthington J. Hypoxia selects for
androgen independent lncap cells with a more malignant geno- and phenotype. Int J Cancer. 2008;123:760-768
Byer SJ, Eckert JM, Brossier NM, Clodfelder-Miller BJ, Turk AN, Carroll AJ, Kappes JC, Zinn KR, Prasain JK,
Carroll SL. Tamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptorindependent manner. Neuro-oncology. 2011;13:28-41
Byrne AT, O'Connor AE, Hall M, Murtagh J, O'Neill K, Curran KM, Mongrain K, Rousseau JA, Lecomte R, McGee
S, Callanan JJ, O'Shea DF, Gallagher WM. Vascular-targeted photodynamic therapy with bf2-chelated tetraarylazadipyrromethene agents: A multi-modality molecular imaging approach to therapeutic assessment. Br J
Cancer. 2009;101:1565-1573
Byrnes C, Malone R, Akhter N, Nass P, Wetterwald A, Cecchini M, Duncan M, Harmon J. Electroporation enhances
transfection efficiency in murine cutaneous wounds. Wound Repair and Regeneration. 2004;12:397-403
Cabral H, Nishiyama N, Kataoka K. Optimization of (1, 2-diamino-cyclohexane) platinum (ii)-loaded polymeric
micelles directed to improved tumor targeting and enhanced antitumor activity. Journal of Controlled Release.
2007;121:146-155
Cai W, Chen K, Li Z, Gambhir S, Chen X. Dual-function probe for pet and near-infrared fluorescence imaging of
tumor vasculature. Journal of Nuclear Medicine. 2007;48:1862
Cai W, Chen X. Multimodality imaging of vascular endothelial growth factor and vascular endothelial growth
factor receptor expression. Front Biosci. 2007;12:4267-4279
Cai W, Chen X. Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted imaging. Nat
Protoc. 2008;3:89-96
Cai W, Shin D, Chen K, Gheysens O, Cao Q, Wang S, Gambhir S, Chen X. Peptide-labeled near-infrared quantum
dots for imaging tumor vasculature in living subjects. Nano Lett. 2006;6:669-676
Cain JW, Hauptschein RS, Stewart JK, Bagci T, Sahagian GG, Jay DG. Identification of cd44 as a surface biomarker
for drug resistance by surface proteome signature technology. Molecular cancer research : MCR.
2011;9:637-647
Cairns RA, Papandreou I, Sutphin PD, Denko NC. Metabolic targeting of hypoxia and hif1 in solid tumors can
enhance cytotoxic chemotherapy. Proceedings of the National Academy of Sciences of the United States of
America. 2007;104:9445-9450
Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, Oh EY, Gaber MW, Finklestein D, Allen M,
Frank A, Bayazitov IT, Zakharenko SS, Gajjar A, Davidoff A, Gilbertson RJ. A perivascular niche for brain tumor
stem cells. Cancer Cell. 2007;11:69-82
Campbell S, Anthony D, Oakley F, Carlsen H, Elsharkawy A, Blomhoff R, Mann D. Hepatic nuclear factor [kappa]
b regulates neutrophil recruitment to the injured brain. Journal of Neuropathology and Experimental
Neurology. 2008;67:223
Canavaci AMC, Bustamante JM, Padilla AM, Perez Brandan CM, Simpson LJ, Xu D, Boehlke CL, Tarleton RL. In
vitro and in vivo high-throughput assays for the testing of anti-trypanosoma cruzi compounds. PLoS Negl Trop
Dis. 2010;4
Canon J, Roudier M, Bryant R, Morony S, Stolina M, Kostenuik P, Dougall W. Inhibition of rankl blocks skeletal
tumor progression and improves survival in a mouse model of breast cancer bone metastasis. Clinical and
Experimental Metastasis. 2008;25:119-129
Cao F, Drukker M, Lin S, Sheikh AY, Xie X, Li Z, Connolly AJ, Weissman IL, Wu JC. Molecular imaging of
embryonic stem cell misbehavior and suicide gene ablation. Cloning and Stem Cells. 2007;9:107-117
Cao F, Lin S, Xie X, Ray P, Patel M, Zhang X, Drukker M, Dylla SJ, Connolly AJ, Chen X, Weissman IL, Gambhir
SS, Wu JC. In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac
delivery. Circulation. 2006;113:1005-1014
Cao F, Rafie A, Abilez O, Wang H, Blundo J, Pruitt B, Zarins C, Wu J. In vivo imaging and evaluation of different
biomatrices for improvement of stem cell survival. Journal of Tissue Engineering and Regenerative Medicine.
2007;1:465-468
Cao F, van der Bogt K, Sadrzadeh A, Xie X, Sheikh A, Wang H, Connolly A, Robbins R, Wu J. Spatial and temporal
kinetics of teratoma formation from murine embryonic stem cell transplantation. Stem Cells Dev.
284.
285.
286.
287.
288.
289.
290.
291.
292.
293.
294.
295.
296.
297.
298.
299.
300.
301.
302.
303.
304.
305.
306.
307.
2007;16:883-892
Cao F, Wagner RA, Wilson KD, Xie X, Fu JD, Drukker M, Lee A, Li RA, Gambhir SS, Weissman IL, Robbins RC, Wu
JC. Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One.
2008;3
Cao F, Xie X, Gollan T, Zhao L, Narsinh K, Lee RJ, Wu JC. Comparison of gene-transfer efficiency in human
embryonic stem cells. Mol Imaging Biol. 2010;12:15-24
Cao L, Yu Y, Darko I, Currier D, Mayeenuddin LH, Wan X, Khanna C, Helman LJ. Addiction to elevated insulinlike growth factor i receptor and initial modulation of the akt pathway define the responsiveness of
rhabdomyosarcoma to the targeting antibody. Cancer Res. 2008;68:8039-8048
Cao XC, Wang B, Cong Y, Yan F. Human umbilical cord mesenchymal stem cell transplantation ameliorates
inflammation in a mouse model of colitis. Gastroenterology. 2009;136:A406-A407
Cao YA, Bachmann MH, Beilhack A, Yang Y, Tanaka M, Swijnenburg RJ, Reeves R, Taylor-Edwards C, Schulz S,
Doyle TC, Fathman CG, Robbins RC, Herzenberg LA, Negrin RS, Contag CH. Molecular imaging using labeled
donor tissues reveals patterns of engraftment, rejection, and survival in transplantation. Transplantation.
2005;80:134-139
Cao YA, Wagers AJ, Beilhack A, Dusich J, Bachmann MH, Negrin RS, Weissman IL, Contag CH. Shifting foci of
hematopoiesis during reconstitution from single stem cells. Proceedings of the National Academy of Sciences of
the United States of America. 2004;101:221-226
Cao YA, Wagers AJ, Karsunky H, Zhao H, Reeves R, Wong RJ, Stevenson DK, Weissman IL, Contag CH. Heme
oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors. Blood.
2008;112:4494-4502
Carlsen H, Alexander G, Austenaa L, Ebihara K, Blomhoff R. Molecular imaging of the transcription factor nf[kappa] b, a primary regulator of stress response. Mutation Research/Fundamental and Molecular Mechanisms of
Mutagenesis. 2004;551:199-211
Carlsen H, Haugen F, Zadelaar S, Kleemann R, Kooistra T, Drevon CA, Blomhoff R. Diet-induced obesity increases
nf-kappab signaling in reporter mice. Genes Nutr. 2009;4:215-222
Carnio MC, Stachelhaus T, Francis KP, Scherer S. Pyridinyl polythiazole class peptide antibiotic micrococcin p1,
secreted by foodborne staphylococcus equorum ws2733, is biosynthesized nonribosomally. European Journal
of Biochemistry. 2001;268:6390-6400
Casarez EV, Dunlap-Brown ME, Conaway MR, Amorino GP. Radiosensitization and modulation of p44/42
mitogen-activated protein kinase by 2-methoxyestradiol in prostate cancer models. Cancer Res.
2007;67:8316-8324
Casey G, Cashman JP, Morrissey D, Whelan MC, Larkin JO, Soden DM, Tangney M, O'Sullivan GC. Sonoporation
mediated immunogene therapy of solid tumors. Ultrasound Med Biol. 2010;36:430-440
Cashman JP, Larkin JO, Casey G, Whelan MC, Collins C, Aarons S, Tangney M, O'Sullivan GC. Immune gene
therapy as a neoadjuvant to surgical excision to control metastatic cancers. Cancer Lett. 2008
Cataliotti A, Tonne JM, Bellavia D, Martin FL, Oehler EA, Harders GE, Campbell JM, Peng KW, Russell SJ,
Malatino LS, Burnett JC, Jr., Ikeda Y. Long-term cardiac pro-b-type natriuretic peptide gene delivery prevents the
d ev el o p men t o f h y p ert en s i v e h eart d i s eas e i n s p o n t an eo u s l y h y p ert en s i v e rat s . Ci r cu l a t i o n .
2011;123:1297-1305
Caughlan RE, Sriram S, Daigle DM, Woods AL, Buco J, Peterson RL, Dzink-Fox J, Walker S, Dean CR. Fmt bypass
in pseudomonas aeruginosa causes induction of mexxy efflux pump expression ▿. Antimicrobial Agents and
Chemotherapy. 2009;53:5015-5021
Cawley NX, Zhou J, Hill JM, Abebe D, Romboz S, Yanik T, Rodriguiz RM, Wetsel WC, Loh YP. The
carboxypeptidase e knockout mouse exhibits endocrinological and behavioral deficits. Endocrinology.
2004;145:5807-5819
Cawood R, Chen HH, Carroll F, Bazan-Peregrino M, van Rooijen N, Seymour LW. Use of tissue-specific microrna
to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells. PLoS Pathog.
2009;5
Cawood R, Wong SL, Di Y, Baban DF, Seymour LW. Microrna controlled adenovirus mediates anti-cancer efficacy
without affecting endogenous microrna activity. PloS one. 2011;6:e16152
Centelles MN, Qian C, Campanero MA, Irache JM. New methodologies to characterize the effectiveness of the
gene transfer mediated by DNA-chitosan nanoparticles. Int J Nanomedicine. 2008;3:451-460
Cernak I. The importance of systemic response in the pathobiology of blast-induced neurotrauma. Front Neurol.
2010;1:151
Chalberg TW, Genise HL, Vollrath D, Calos MP. Phic31 integrase confers genomic integration and long-term
transgene expression in rat retina. Invest Ophthalmol Vis Sci. 2005;46:2140-2146
Chalberg TW, Vankov A, Molnar FE, Butterwick AF, Huie P, Calos MP, Palanker DV. Gene transfer to rabbit retina
with electron avalanche transfection. Invest Ophthalmol Vis Sci. 2006;47:4083-4090
Chambliss KL, Wu Q, Oltmann S, Konaniah ES, Umetani M, Korach KS, Thomas GD, Mineo C, Yuhanna IS, Kim
SH, Madak-Erdogan Z, Maggi A, Dineen SP, Roland CL, Hui DY, Brekken RA, Katzenellenbogen JA,
Katzenellenbogen BS, Shaul PW. Non-nuclear estrogen receptor α signaling promotes cardiovascular protection
but not uterine or breast cancer growth in mice. Journal of Clinical Investigation. 2010;120:2319-2330
Chan C, Paulmurugan R, Gambhir S. Real-time imaging of disruption of human heat shock protein 90/co-
308.
309.
310.
311.
312.
313.
314.
315.
316.
317.
318.
319.
320.
321.
322.
323.
324.
325.
326.
327.
328.
329.
330.
331.
chaperone p23 interactions by hsp90 inhibitors in living subjects. Proceedings of the American Association for
Cancer Research. 2006;2006:565
Chan CT, Paulmurugan R, Gheysens OS, Kim J, Chiosis G, Gambhir SS. Molecular imaging of the efficacy of heat
shock protein 90 inhibitors in living subjects. Cancer Res. 2008;68:216-226
Chan CT, Paulmurugan R, Reeves RE, Solow-Cordero D, Gambhir SS. Molecular imaging of phosphorylation
events for drug development. Mol Imaging Biol. 2009;11:144-158
Chan J, Kumar S, Fisk NM. First trimester embryo-fetoscopic and ultrasound-guided fetal blood sampling for ex
vivo viral transduction of cultured human fetal mesenchymal stem cells. Hum Reprod. 2008;23:2427-2437
Chan JK, Hamilton CA, Cheung MK, Karimi M, Baker J, Gall JM, Schulz S, Thorne SH, Teng NN, Contag CH, Lum
LG, Negrin RS. Enhanced killing of primary ovarian cancer by retargeting autologous cytokine-induced killer
cells with bispecific antibodies: A preclinical study. Clin Cancer Res. 2006;12:1859-1867
Chan KM, Raikwar SP, Zavazava N. Strategies for differentiating embryonic stem cells (esc) into insulinproducing cells and development of non-invasive imaging techniques using bioluminescence. Immunol Res.
2007;39:261-270
Chanda D, Isayeva T, Kumar S, Hensel JA, Sawant A, Ramaswamy G, Siegal GP, Beatty MS, Ponnazhagan S.
Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in prostate cancer bone metastasis.
Clin Cancer Res. 2009;15:7175-7185
Chanda D, Isayeva T, Kumar S, Siegal GP, Szafran AA, Zinn KR, Reddy VV, Ponnazhagan S. Systemic
osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of breast cancer bone
metastasis. Mol Ther. 2008;16:871-878
Chandna P, Saad M, Wang Y, Ber E, Khandare J, Vetcher AA, Soldatenkov VA, Minko T. Targeted proapoptotic
anticancer drug delivery system. Mol Pharm. 2007;4:668-678
Chandran SS, Williams SA, Denmeade SR. Extended-release peg-luciferin allows for long-term imaging of firefly
luciferase activity in vivo. Luminescence. 2009;24:35-38
Chang CL, Ma B, Pang X, Wu TC, Hung CF. Treatment with cyclooxygenase-2 inhibitors enables repeated
administration of vaccinia virus for control of ovarian cancer. Mol Ther. 2009;17:1365-1372
Chang CL, Wu TC, Hung CF. Control of human mesothelin-expressing tumors by DNA vaccines. Gene Ther.
2007;14:1189-1198
Chang EI, Bonillas RG, El-Ftesi S, Chang EI, Ceradini DJ, Vial IN, Chan DA, Michaels Jt, Gurtner GC. Tissue
engineering using autologous microcirculatory beds as vascularized bioscaffolds. Faseb J. 2008
Chang MH, Cirillo SLG, Cirillo JD. Using luciferase to image bacterial infections in mice. J Vis Exp. 2011:e2547
Chang PC, Cirelli JA, Jin Q, Seol YJ, Sugai JV, D'Silva NJ, Danciu TE, Chandler LA, Sosnowski BA, Giannobile
WV. Adenovirus encoding human platelet-derived growth factor-b delivered to alveolar bone defects exhibits
safety and biodistribution profiles favorable for clinical use. Human Gene Therapy. 2009;20:486-496
CHANG T, CHANG Y, HO T, HSIANG C, YU C, LEE T, LIN W, CHANG C. Noninvasive bioluminescent and
micropet imaging for the regulation of nf- b in human hepatoma-bearing mice. Anticancer Research.
2009;29:987
Chang YF, Lin YY, Wang HE, Liu RS, Pang F, Hwang JJ. Monitoring of tumor growth and metastasis potential in
mda-mb-435s/tk-luc human breast cancer xenografts. Nuclear Instruments & Methods in Physics Research
Section a-Accelerators Spectrometers Detectors and Associated Equipment. 2007;571:155-159
Charafe-Jauffret E, Ginestier C, Iovino F, Tarpin C, Diebel M, Esterni B, Houvenaeghel G, Extra JM, Bertucci F,
Jacquemier J, Xerri L, Dontu G, Stassi G, Xiao Y, Barsky SH, Birnbaum D, Viens P, Wicha MS. Aldehyde
dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast
cancer. Clin Cancer Res. 2010;16:45-55
Charafe-Jauffret E, Ginestier C, Iovino F, Wicinski J, Cervera N, Finetti P, Hur MH, Diebel ME, Monville F,
Dutcher J, Brown M, Viens P, Xerri L, Bertucci F, Stassi G, Dontu G, Birnbaum D, Wicha MS. Breast cancer cell
lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer
Res. 2009;69:1302-1313
Charre L, Roggen F, Lemaire J, Mathijs J, Goffette P, Danse E, Lerut J. Hematochezia and congenital extrahepatic
portocaval shunt with absent portal vein: Successful treatment by liver transplantation. Transplantation.
2004;78:1404
Chatterjea D, Burns-Guydish SM, Sciuto TE, Dvorak A, Contag CH, Galli SJ. Adoptive transfer of mast cells does
not enhance the impaired survival of kitw/kitw-v mice in a model of low dose intraperitoneal infection with
bioluminescent salmonella typhimurium. Immunology Letters. 2005;99:122-129
Chaudhuri T, Cao Z, Ponnazhagan S, Stargel A, Simhadri P, Zhou T, Lobuglio A, Buchsbaum D, Zinn K.
Bioluminescence imaging of non-palpable breast cancer xenografts during treatment with tra-8, an anti-dr5
antibody and chemotherapy. Proceedings of the American Association for Cancer Research. 2004;2004:481
Chaudhuri T, Cao Z, Ponnazhagan S, Stargel A, Simhadri P, Zhou T, Lobuglio A, Buchsbaum D, Zinn K. Detection
of disseminated breast cancer growth and treatment response using non-invasive bioluminescence imaging.
Journal of Clinical Oncology. 2004;22:742
Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM. Hyperpolarized (13)c mr spectroscopic
imaging can be used to monitor everolimus treatment in vivo in an orthotopic rodent model of glioblastoma.
NeuroImage. 2011
Cheatham M, Zheng J, Huynh K, Du G, Edge R, Anderson C, Zuo J, Ryan A, Dallos P. Evaluation of an
332.
333.
334.
335.
336.
337.
338.
339.
340.
341.
342.
343.
344.
345.
346.
347.
348.
349.
350.
351.
352.
353.
354.
355.
356.
357.
independent prestin mouse model derived from the 129s1 strain. Audiology and Neurotology. 2007;12:378-390
Cheeran MCJ, Mutnal MB, Hu S, Armien A, Lokensgard JR. Reduced lymphocyte infiltration during
cytomegalovirus brain infection of interleukin-10-deficient mice. Journal of Neurovirology. 2009;15:334-342
Chekmasova AA, Rao TD, Nikhamin Y, Park KJ, Levine DA, Spriggs DR, Brentjens RJ. Successful eradication of
established peritoneal ovarian tumors in scid-beige mice following adoptive transfer of t cells genetically
targeted to the muc16 antigen. Clin Cancer Res. 2010;16:3594-3606
Chen AA, Thomas DK, Ong LL, Schwartz RE, Golub TR, Bhatia SN. Humanized mice with ectopic artificial liver
t i s s u es . Pr o ceed i n g s o f t h e Na t i o n a l Aca d emy o f S ci en ces o f t h e Un i t ed S t a t es o f Amer i ca .
2011;108:11842-11847
Chen C, Kim J, Liu D, Rettig GR, McAnuff MA, Martin ME, Rice KG. Synthetic pegylated glycoproteins and their
utility in gene delivery. Bioconjugate Chemistry. 2007;18:371-378
Chen CC, Hwang JJ, Ting G, Tseng YL, Wang SJ, Whang-Peng J. Monitoring and quantitative assessment of
tumor burden using in vivo bioluminescence imaging. Nuclear Instruments & Methods in Physics Research
Section a-Accelerators Spectrometers Detectors and Associated Equipment. 2007;571:437-441
Chen CH, Yeh YC, Wu GJ, Huang YH, Lai WF, Liu JY, Tzeng CR. Tracking the rejection and survival of mouse
ovarian iso- and allografts in vivo with bioluminescent imaging. Reproduction. 2010;140:105-112
Chen CT, Yamaguchi H, Lee HJ, Du Y, Lee HH, Xia W, Yu WH, Hsu JL, Yen CJ, Sun HL, Wang Y, Yeh ET,
Hortobagyi GN, Hung MC. Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine
deaminase-uracil phosphoribosyltransferase. Mol Cancer Ther. 2011;10:1327-1336
Chen E, Hewel J, Krueger J, Tiraby C, Weber M, Kralli A, Becker K, Yates J, Felding-Habermann B. Adaptation of
energy metabolism in breast cancer brain metastases. Cancer Res. 2007;67:1472
Chen H, Ma H, Sytwu H, Wang H, Chen C, Liu S, Chen C, Chen H, Wang C. Neural stem cells secrete factors that
promote auditory cell proliferation via a leukemia inhibitory factor signaling pathway. Journal of Neuroscience
Research. 2010;88:3308-3318
Chen H, Yueyun, Yang J, O'Brien CJ, Lee SL, Mazurkiewicz JE, Haataja S, Yan JH, Gao GF, Zhang JR. Genetic
requirement for pneumococcal ear infection. PLoS One. 2008;3
Chen IY, Greve JM, Gheysens O, Willmann JK, Rodriguez-Porcel M, Chu P, Sheikh AY, Faranesh AZ,
Paulmurugan R, Yang PC, Wu JC, Gambhir SS. Comparison of optical bioluminescence reporter gene and
superparamagnetic iron oxide mr contrast agent as cell markers for noninvasive imaging of cardiac cell
transplantation. Mol Imaging Biol. 2009;11:178-187
Chen J, Corbin IR, Li H, Cao W, Glickson JD, Zheng G. Ligand conjugated low-density lipoprotein nanoparticles
for enhanced optical cancer imaging in vivo. J Am Chem Soc. 2007;129:5798-5799
Chen J, Yao Y, Gong C, Yu F, Su S, Liu B, Deng H, Wang F, Lin L, Yao H, Su F, Anderson KS, Liu Q, Ewen ME, Yao
X, Song E. Ccl18 from tumor-associated macrophages promotes breast cancer metastasis via pitpnm3. Cancer
cell. 2011;19:541-555
Chen JY, Tang YA, Huang SM, Juan HF, Wu LW, Sun YC, Wang SC, Wu KW, Balraj G, Chang TT, Li WS, Cheng
HC, Wang YC. A novel sialyltransferase inhibitor suppresses fak/paxillin signaling and cancer angiogenesis and
metastasis pathways. Cancer Res. 2011;71:473-483
Chen KJ, Chiu YL, Chen YM, Ho YC, Sung HW. Intracellularly monitoring/imaging the release of doxorubicin
from ph-responsive nanoparticles using forster resonance energy transfer. Biomaterials. 2011;32:2586-2592
Chen L, Shen R, Ye Y, Pu XA, Liu X, Duan W, Wen J, Zimmerer J, Wang Y, Liu Y, Lasky LC, Heerema NA, Perrotti D,
Ozato K, Kuramochi-Miyagawa S, Nakano T, Yates AJ, Carson IW, Lin H, Barsky SH, Gao JX. Precancerous stem
cells have the potential for both benign and malignant differentiation. PLoS One. 2007;2
Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY. Migrastatin analogues target fascin to block tumour metastasis.
Nature. 2010;464:1062-1066
Chen SJ, Limberis MP, Bish L, Hovhannisyan R, Saighal S, Jno-Charles O, Sweeney HL, Sandhu A, Johnston J,
Wilson JM. Aav vectors for tissue-specific, regulated expression in heart, liver and lung. Molecular Therapy.
2010;18:S243
Chen W, Olson J, McMahan CN, Choudhary M, Caldas H, Metheny-Barlow LJ. Generation of a mouse model of
breast cancer brain metastasis. Proceedings of the American Association for Cancer Research Annual Meeting.
2010;51:113-114
Chen WH, Liu HY, Lo WC, Wu SC, Chi CH, Chang HY, Hsiao SH, Wu CH, Chiu WT, Chen BJ, Deng WP.
Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich
plasma. Biomaterials. 2009;30:5523-5533
Chen X, Conti PS, Moats RA. In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor
xenografts. Cancer Res. 2004;64:8009-8014
Chen X, Kaufman D. Bioluminescence imaging of pancreatic islet transplants. Current Medicinal ChemistryImmunology, Endocrine & Metabolic Agents. 2004;4:301-308
Chen X, Kaufman DB. Bioluminescent imaging of transplanted islets. Bioluminescence. 2009:75-85.
Chen X, Larson CS, West J, Zhang X, Kaufman DB. In vivo detection of extrapancreatic insulin gene expression in
diabetic mice by bioluminescence imaging. PLoS One. 2010;5:e9397
Chen X, Zhang X, Larson C, Baker M, Kaufman D. In vivo bioluminescence imaging of transplanted islets and
early detection of graft rejection. Transplantation. 2006;81:1421
Chen X, Zhang X, Larson C, Chen F, Kissler H, Kaufman DB. The epididymal fat pad as a transplant site for
358.
359.
360.
361.
362.
363.
364.
365.
366.
367.
368.
369.
370.
371.
372.
373.
374.
375.
376.
377.
378.
379.
380.
381.
minimal islet mass. Transplantation. 2007;84:122-125
Chen X, Zhang X, Larson C, Xia G, Kaufman DB. Prolonging islet allograft survival using in vivo
bioluminescence imaging to guide timing of antilymphocyte serum treatment of rejection. Transplantation.
2008;85:1246-1252
Chen YY, Jensen MC, Smolke CD. Genetic control of mammalian t-cell proliferation with synthetic rna regulatory
systems. Proceedings of the National Academy of Sciences of the United States of America.
2010;107:8531-8536
Cheng CM, Lu YL, Chuang KH, Hung WC, Shiea J, Su YC, Kao CH, Chen BM, Roffler S, Cheng TL. Tumortargeting prodrug-activating bacteria for cancer therapy. Cancer Gene Ther. 2008;15:393-401
Cheng D, Lo C, Sefton MV. Effect of mouse vegf164 on the viability of hydroxyethyl methacrylate-methyl
methacrylate-microencapsulated cells in vivo: Bioluminescence imaging. J Biomed Mater Res A.
2008;87:321-331
Cheng D, Sefton MV. Dual delivery of placental growth factor and vascular endothelial growth factor from poly
(hydroxyethyl methacrylate-co-methyl methacrylate) microcapsules containing doubly transfected luciferaseexpressing l929 cells. Tissue Eng Part A. 2009
Cheng JC, Kinjo K, Judelson D, Chang J, Wu WS, Schmid I, Shankar DB, Kasahara N, Stripecke R, Bhatia R,
Landaw EM, Sakamoto KM. Creb is a critical regulator of normal hematopoiesis and leukemogenesis. Blood.
2007
Cheng K, Li TS, Malliaras K, Davis DR, Zhang Y, Marban E. Magnetic targeting enhances engraftment and
functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction. Circulation research.
2010;106:1570-1581
Cheng Z, Levi J, Xiong Z, Gheysens O, Keren S, Chen X, Gambhir SS. Near-infrared fluorescent deoxyglucose
analogue for tumor optical imaging in cell culture and living mice. Bioconjugate Chemistry. 2006;17:662-669
Cheng Z, Wu Y, Xiong Z, Gambhir SS, Chen X. Near-infrared fluorescent rgd peptides for optical imaging of
integrin (alpha)v(beta)3 expression in living mice. Bioconjugate Chemistry. 2005;16:1433-1441
Chesler L, Goldenberg DD, Collins R, Grimmer M, Kim GE, Tihan T, Nguyen K, Yakovenko S, Matthay KK, Weiss
WA. Chemotherapy-induced apoptosis in a transgenic model of neuroblastoma proceeds through p53
induction12. Neoplasia. 2008;10:1268-1274
Cheung L, Han J, Beilhack A, Joshi S, Wilburn P, Dua A, An A, Rockson S. An experimental model for the study of
lymphedema and its response to therapeutic lymphangiogenesis. BioDrugs. 2006;20:363-370
Chewning JH, Dugger KJ, Chaudhuri TR, Zinn KR, Weaver CT. Bioluminescence-based visualization of cd4 t cell
dynamics using a t lineage-specific luciferase transgenic model. BMC Immunol. 2009;10:44
Chi L, Yu J, Zhu H, Li X, Zhu S, Li Z, Pettigrew LC, Grass D, Hickman JJ, Kindy MS. Dual neuronal response to
tumor necrosis factor-alpha following spinal cord injury. Neural Regeneration Research. 2010;5:917-926
Chimenti I, Smith RR, Li TS, Gerstenblith G, Messina E, Giacomello A, Marban E. Relative roles of direct
regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ
Res. 2010
Chin PT, Buckle T, Aguirre de Miguel A, Meskers SC, Janssen RA, van Leeuwen FW. Dual-emissive quantum dots
for multispectral intraoperative fluorescence imaging. Biomaterials. 2010;31:6823-6832
Chiou JF, Wu AT, Wang WT, Kuo TH, Gelovani JG, Lin IH, Wu CH, Chiu WT, Deng WP. A preclinical evaluation of
antrodia camphorata alcohol extracts in the treatment of non-small cell lung cancer using non-invasive
molecular imaging. Evidence-based complementary and alternative medicine : eCAM. 2011;2011:914561
Chiu CC, Lin CY, Lee LY, Chen YJ, Kuo TF, Chang JT, Liao CT, Wang HM, Yen TC, Shen CR, Liao SK, Cheng AJ.
Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as
a molecular target of therapeutic intervention. Mol Cancer Ther. 2008;7:2788-2797
Cho H, Indig GL, Weichert J, Shin HC, Kwon GS. In vivo cancer imaging by poly(ethylene glycol)-b-poly
(varepsilon-caprolactone) micelles containing a near-infrared probe. Nanomedicine : nanotechnology, biology,
and medicine. 2011
Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung
AL, Cheng G, Modlin RL, Miller LS. Il-17 is essential for host defense against cutaneous staphylococcus aureus
infection in mice. Journal of Clinical Investigation. 2010;120:1762-1773
Cho JS, Zussman J, Donegan NP, Ramos RI, Garcia NC, Uslan DZ, Iwakura Y, Simon SI, Cheung AL, Modlin RL,
Kim J, Miller LS. Noninvasive in vivo imaging to evaluate immune responses and antimicrobial therapy against
staphylococcus aureus and usa300 mrsa skin infections. The Journal of investigative dermatology.
2011;131:907-915
Cho W, Hagemann TL, Johnson DA, Johnson JA, Messing A. Dual transgenic reporter mice as a tool for
monitoring expression of gfap. Journal of Neurochemistry. 2009;110:343-351
Cho WS, Cho M, Kim SR, Choi M, Lee JY, Han BS, Park SN, Yu MK, Jon S, Jeong J. Pulmonary toxicity and
kinetic study of cy5.5-conjugated superparamagnetic iron oxide nanoparticles by optical imaging. Toxicol Appl
Pharmacol. 2009;239:106-115
Choi CY, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS, Giaccia AJ. Molecular
imaging of hypoxia-inducible factor 1 alpha and von hippel-lindau interaction in mice. Mol Imaging.
2008;7:139-146
Choi HG, Ren P, Adrian F, Sun F, Lee HS, Wang X, Ding Q, Zhang G, Xie Y, Zhang J, Liu Y, Tuntland T, Warmuth
382.
383.
384.
385.
386.
387.
388.
389.
390.
391.
392.
393.
394.
395.
396.
397.
398.
399.
400.
401.
402.
403.
404.
405.
406.
407.
M, Manley PW, Mestan J, Gray NS, Sim T. A type-ii kinase inhibitor capable of inhibiting the t315i "gatekeeper"
mutant of bcr-abl. Journal of medicinal chemistry. 2010;53:5439-5448
Choi JW, Kim DG, Lee AE, Kim HR, Lee JY, Kwon NH, Shin YK, Hwang SK, Chang SH, Cho MH, Choi YL, Kim J,
Oh SH, Kim B, Kim SY, Jeon HS, Park JY, Kang HP, Park BJ, Han JM, Kim S. Cancer-associated splicing variant of
tumor suppressor aimp2/p38: Pathological implication in tumorigenesis. PLoS genetics. 2011;7:e1001351
Choi YS, Hoory T, Monie A, Wu A, Connolly D, Hung CF. Alpha-galactosylceramide enhances the protective and
therapeutic effects of tumor cell based vaccines for ovarian tumors. Vaccine. 2008;26:5855-5863
Chong AK, Satterwhite T, Pham HM, Costa MA, Luo J, Longaker MT, Wyss-Coray T, Chang J. Live imaging of
smad2/3 signaling in mouse skin wound healing. Wound Repair Regen. 2007;15:762-766
Chou CK, Hung JY, Liu JC, Chen CT, Hung MC. An attenuated salmonella oral DNA vaccine prevents the growth
of hepatocellular carcinoma and colon cancer that express alpha-fetoprotein. Cancer Gene Ther.
2006;13:746-752
Chou ST, Leng Q, Scaria P, Woodle M, Mixson AJ. Selective modification of hk peptides enhances sirna silencing
of tumor targets in vivo. Cancer gene therapy. 2011
Chow TH, Lin YY, Hwang JJ, Wang HE, Tseng YL, Pang VF, Wang SJ, Whang-Peng J, Ting G. Diagnostic and
therapeutic evaluation of 111in-vinorelbine-liposomes in a human colorectal carcinoma ht-29/luc-bearing
animal model. Nuclear Medicine and Biology. 2008;35:623-634
Choy G, Choyke P, Libutti SK. Current advances in molecular imaging: Noninvasive in vivo bioluminescent and
fluorescent optical imaging in cancer research. Molecular Imaging. 2003;2:303-312
Christian DA, Cai S, Garbuzenko OB, Harada T, Zajac AL, Minko T, Discher DE. Flexible filaments for in vivo
imaging and delivery: Persistent circulation of filomicelles opens the dosage window for sustained tumor
shrinkage. Mol Pharm. 2009;6:1343-1352
Chu K, Cheng CJ, Ye X, Lee YC, Zurita AJ, Chen DT, Yu-Lee LY, Zhang S, Yeh ET, Hu MCT, Logothetis CJ, Lin SH.
Cadherin-11 promotes the metastasis of prostate cancer cells to bone. Mol Cancer Res. 2008;6:1259-1267
Chuang CM, Monie A, Wu A, Hung CF. Combination of apigenin treatment with therapeutic hpv DNA
vaccination generates enhanced therapeutic antitumor effects. Journal of Biomedical Science. 2009;16:49
Chuang CM, Monie A, Wu A, Mao CP, Hung CF. Treatment with ll-37 peptide enhances antitumor effects induced
by cpg oligodeoxynucleotides against ovarian cancer. Human Gene Therapy. 2009;20:303-313
Chuang CM, Monie A, Wu A, Pai SI, Hung CF. Combination of viral oncolysis and tumor-specific immunity to
control established tumors. Clin Cancer Res. 2009;15:4581-4588
Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK. Secreted gaussia luciferase as a biomarker for
monitoring tumor progression and treatment response of systemic metastases. PLoS One. 2009;4:e8316
Chung H, Cartwright M, Bortz D, Jackson T, Younger J. Dynamical system analysis of staphylococcus
epidermidis bloodstream infection. Shock. 2008;30:518
Chung WJ, Lyons SA, Nelson GM, Hamza H, Gladson CL, Gillespie GY, Sontheimer H. Inhibition of cystine
uptake disrupts the growth of primary brain tumors. Journal of Neuroscience. 2005;25:7101-7110
Cirstoiu-Hapca A, Buchegger F, Lange N, Bossy L, Gurny R, Delie F. Benefit of anti-her2-coated paclitaxel-loaded
immuno-nanoparticles in the treatment of disseminated ovarian cancer: Therapeutic efficacy and biodistribution
in mice. Journal of controlled release : official journal of the Controlled Release Society. 2010;144:324-331
Claes F, Vodnala SK, van Reet N, Boucher N, Lunden-Miguel H, Baltz T, Goddeeris BM, Büscher P, Rottenberg
ME. Bioluminescent imaging of trypanosoma brucei shows preferential testis dissemination which may hamper
drug efficacy in sleeping sickness. PLoS Negl Trop Dis. 2009;3
Claser C, Malleret B, Gun SY, Wong AY, Chang ZW, Teo P, See PC, Howland SW, Ginhoux F, Renia L. Cd8+ t cells
and ifn-gamma mediate the time-dependent accumulation of infected red blood cells in deep organs during
experimental cerebral malaria. PloS one. 2011;6:e18720
Cleary P, Zhang Y, Park H. Nasal associated lymphoid tissue & m cells, a window to persistent streptococcal
infections. Indian Journal of Medical Research. 2004;119:57-60
Clermont A, Lyons S, Dusich J, Scatena C, Purchio T, Jenkins D. Characterization of ll/2 (lewis lung carcinoma)
luciferase-expressing cells in vitro and in vivo using bioluminescent imaging techniques. Proceedings of the
American Association for Cancer Research. 2004;2004:215
Close DM, Patterson SS, Ripp S, Baek SJ, Sanseverino BJ, Sayler GS. Autonomous bioluminescent expression of
the bacterial luciferase gene cassette (lux) in a mammalian cell line. PLoS ONE. 2010
Cmielewski P, Anson D, Parsons D. Differences in re-emergence of lung luciferase expression following nasal
instillation of a lentiviral gene vector in normal and cystic fibrosis mice. Respirology. 2010;15:A9
Coffelt SB, Marini FC, Watson K, Zwezdaryk KJ, Dembinski JL, LaMarca HL, Tomchuck SL, zu Bentrup KH, Danka
ES, Henkle SL, Scandurro AB. The pro-inflammatory peptide ll-37 promotes ovarian tumor progression through
recruitment of multipotent mesenchymal stromal cells. Proceedings of the National Academy of Sciences of the
United States of America. 2009;106:3806-3811
Colby DW, Prusiner SB. Prions. Cold Spring Harbor perspectives in biology. 2011;3:a006833
Collins C, Tangney M, Larkin J, Casey G, Whelan M, Cashman J, Murphy J, Soden D, Vejda S, McKenna S. Local
gene therapy of solid tumors with gm-csf and b7-1 eradicates both treated and distal tumors. Cancer Gene
Therapy. 2006;13:1061-1071
Collisson E, De A, Suzuki H, Gambhir S, Kolodney M. Treatment of metastatic melanoma with an orally available
inhibitor of the ras-raf-mapk cascade. Cancer Res. 2003;63:5669
408.
409.
410.
411.
412.
413.
414.
415.
416.
417.
418.
419.
420.
421.
422.
423.
424.
425.
426.
427.
428.
429.
430.
431.
432.
433.
434.
435.
Collisson EA, Kleer C, Wu M, De A, Gambhir SS, Merajver SD, Kolodney MS. Atorvastatin prevents rhoc
isoprenylation, invasion, and metastasis in human melanoma cells. Molecular Cancer Therapy. 2003;2:941-948
Conenello GM, Palese P. Influenza a virus pb1-f2: A small protein with a big punch. Cell Host Microbe.
2007;2:207-209
Cong A, Cong W, Shen H, Wang G, Lu Y, Chatziioannou A. Optical property characterization based on a phase
function approximation model. Proc IEEE Int Symp Biomed Imaging. 2009:446-449
Conn EM, Botkjaer KA, Kupriyanova TA, Andreasen PA, Deryugina EI, Quigley JP. Comparative analysis of
metastasis variants derived from human prostate carcinoma cells : Roles in intravasation of vegf-mediated
angiogenesis and upa-mediated invasion. American Journal of Pathology. 2009;175:1638-1652
Connell CM, Shibata A, Tookman LA, Archibald KM, Flak MB, Pirlo KJ, Lockley M, Wheatley SP, McNeish IA.
Genomic DNA damage and atr-chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer
cells. The Journal of clinical investigation. 2011;121:1283-1297
Conradi L, Pahrmann C, Schmidt S, Deuse T, Hansen A, Eder A, Reichenspurner H, Robbins RC, Eschenhagen T,
Schrepfer S. Bioluminescence imaging for assessment of immune responses following implantation of
engineered heart tissue (eht). J Vis Exp. 2011:e2605
Contag C, Contag P. Viewing disease progression through a bioluminescent window. Optics and Photonics
News. 1996;7:22-23
Contag CH, Bachmann MH. Advances in in vivo bioluminescence imaging of gene expression. Annual Review of
Biomedical Engineering. 2002;4:235-260
Contag CH, Contag PR, Mullins JI, Spilman SD, Stevenson DK, Benaron DA. Photonic detection of bacterial
pathogens in living hosts. Molecular Microbiology. 1995;18:593-603
Contag CH, Jenkins D, Contag PR, Negrin RS. Use of reporter genes for optical measurements of neoplastic
disease in vivo1. Neoplasia. 2000;2:41-52
Contag CH, Ross BD. It's not just about anatomy: In vivo bioluminescence imaging as an eyepiece into biology.
Journal of Magnetic Resonance Imaging. 2002;16:378-387
Contag CH, Spilman SD, Contag PR, Oshiro M, Eames B, Dennery P, Stevenson DK, Benaron DA. Visualizing gene
expression in living mammals using a bioluminescent reporter. Photochemistry and Photobiology.
1997;66:523-531
Contag PR. Whole-animal cellular and molecular imaging to accelerate drug development. Drug Discov Today.
2002;7:555-562
Contag PR. Unraveling the complexicity of oncogenesis through in vivo optical imaging. In: LaRochelle WJ,
Shimkets RA, eds. Cancer drug discovery and development: The oncogenomics handbook. Totowa, NJ: Humana
Press, Inc.; 2005:263-274.
Contag PR. Bioluminescence imaging to evaluate infections and host response in vivo. Innate immunity.
2007:101-118.
Contag PR. Bioluminescence imaging to evaluate infections and host response in vivo. Methods Mol Biol.
2008;415:101-118
Contag PR, Olomu IN, Stevenson DK, Contag CH. Bioluminescent indicators in living mammals. Nature
Medicine. 1998;4:245-247
Contero A, Richer E, Gondim A, Mason RP. High-throughput quantitative bioluminescence imaging for
assessing tumor burden. Methods Mol Biol. 2009;574:37-45
Conway AE, Lindgren A, Galic Z, Pyle AD, Wu H, Zack JA, Pelligrini M, Teitell MA, Clark A. A pluripotency and
self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cellderived tumors. Stem Cells. 2008
Cook SH, Griffin DE. Luciferase imaging of a neurotropic viral infection in intact animals. J Virol.
2003;77:5333-5338
Cooney DS, Chambers CB, Suchy H, Hornick MC, Reichensperger J, Neumeister MW. Transgene expression in a
model of composite tissue allotransplantation. Plast Reconstr Surg. 2010;125:837-845
Cooper LJ, Al-Kadhimi Z, DiGiusto D, Kalos M, Colcher D, Raubitschek A, Forman SJ, Jensen MC. Development
and application of cd19-specific t cells for adoptive immunotherapy of b cell malignancies. Blood Cells Mol Dis.
2004;33:83-89
Cooper LJ, Al-Kadhimi Z, Serrano LM, Pfeiffer T, Olivares S, Castro A, Chang WC, Gonzalez S, Smith D, Forman
SJ, Jensen MC. Enhanced antilymphoma efficacy of cd19-redirected influenza mp1-specific ctls by cotransfer of t
cells modified to present influenza mp1. Blood. 2005;105:1622-1631
Coppola JM, Ross BD, Rehemtulla A. Non-invasive imaging of apoptosis and its application in cancer
therapeutics. Clinical Cancer Research. 2008;14:2492-2501
Corbin I, Chen J, Cao W, Li H, Lund-Katz S, Zheng G. Enhanced cancer-targeted delivery using engineered highdensity lipoprotein-based nanocarriers. Journal of Biomedical Nanotechnology. 2007;3:367-376
Corbin I, Chen J, Li H, Cao W, Zheng G. Functionalizing low-density lipoprotein nanoparticles for in vivo nearinfrared optical imaging of cancer. Progress in Biomedical Optics and Engineering. 2007;6626
Cordeau P, Jr., Lalancette-Hebert M, Weng YC, Kriz J. Live imaging of neuroinflammation reveals sex and
estrogen effects on astrocyte response to ischemic injury. Stroke. 2008;39:935-942
Cormode DP, Chandrasekar R, Delshad A, Briley-Saebo KC, Calcagno C, Barazza A, Mulder WJM, Fisher EA,
Fayad ZA. Comparison of synthetic hdl contrast agents for mr imaging of atherosclerosis. Bioconjugate
436.
437.
438.
439.
440.
441.
442.
443.
444.
445.
446.
447.
448.
449.
450.
451.
452.
453.
454.
455.
456.
457.
458.
459.
460.
461.
Chemistry. 2009;20:937-943
Cormode DP, Skajaa T, van Schooneveld MM, Koole R, Jarzyna P, Lobatto ME, Calcagno C, Barazza A, Gordon
RE, Zanzonico P, Fisher EA, Fayad ZA, Mulder WJM. Nanocrystal core high-density lipoproteins: A
multimodality contrast agent platform. Nano Lett. 2008;8:3715-3723
Corr S, Hill C, Gahan C. An in vitro cell-culture model demonstrates internalin-and hemolysin-independent
translocation of listeria monocytogenes across m cells. Microbial Pathogenesis. 2006;41:241-250
Corr SC, Li Y, Riedel CU, O'Toole PW, Hill C, Gahan CGM. Bacteriocin production as a mechanism for the
antiinfective activity of lactobacillus salivarius ucc118. Proceedings of the National Academy of Sciences of the
United States of America. 2007;104:7617-7621
Correia DV, d'Orey F, Cardoso BA, Lança T, Grosso AR, deBarros A, Martins LR, Barata JT, Silva-Santos B. Highly
active microbial phosphoantigen induces rapid yet sustained mek/erk- and pi-3k/akt-mediated signal
transduction in anti-tumor human γδ t-cells. PLOS ONE. 2009
Corsello SM, Roti G, Ross KN, Chow KT, Galinsky I, DeAngelo DJ, Stone RM, Kung AL, Golub TR, Stegmaier K.
Identification of aml1-eto modulators by chemical genomics. Blood. 2009;113:6193-6205
Costa GL, Sandora MR, Nakajima A, Nguyen EV, Taylor-Edwards C, Slavin AJ, Contag CH, Fathman CG, Benson
JM. Adoptive immunotherapy of experimental autoimmune encephalomyelitis via t cell delivery of the il-12 p40
subunit. Journal of Immunology. 2001;167:2379-2387
Costantini TW, Peterson CY, Kroll L, Loomis WH, Eliceiri BP, Baird A, Bansal V, Coimbra R. Role of p38 mapk in
burn-induced intestinal barrier breakdown. J Surg Res. 2009;156:64-69
Costantini TW, Peterson CY, Putnam JG, Loomis WH, Borboa AK, Baird A, Eliceiri BP, Bansal V, Coimbra R. Gut
barrier injury is associated with activation of enteric glia cells. Surgical Infections. 2009;10:194
Costes B, Stalin Raj V, Michel B, Fournier G, Thirion M, Gillet L, Mast J, Lieffrig F, Bremont M, Vanderplasschen
A. The major portal of entry of koi herpesvirus in cyprinus carpio is the skin. J Virol. 2009
Cotter PD, Draper LA, Lawton EM, Daly KM, Groeger DS, Casey PG, Ross RP, Hill C. Listeriolysin s, a novel
peptide haemolysin associated with a subset of lineage i listeria monocytogenes. PLoS Pathog. 2008;4
Couillard-Despres S, Finkl R, Winner B, Ploetz S, Wiedermann D, Aigner R, Bogdahn U, Winkler J, Hoehn M,
Aigner L. In vivo optical imaging of neurogenesis: Watching new neurons in the intact brain. Mol Imaging.
2008;7:28-34
Cowey S, Szafran AA, Kappes J, Zinn KR, Siegal GP, Desmond RA, Kim H, Evans L, Hardy RW. Breast cancer
metastasis to bone: Evaluation of bioluminescent imaging and microspect/ct for detecting bone metastasis in
immunodeficient mice. Clin Exp Metastasis. 2007
Craft N, Bruhn K, Nguyen B, Prins R, Lin J, Liau L, Miller J. The tlr7 agonist imiquimod enhances the antimelanoma effects of a recombinant listeria monocytogenes vaccine. The Journal of Immunology. 2005;175:1983
Craft N, Bruhn KW, Nguyen BD, Prins R, Liau LM, Collisson EA, De A, Kolodney MS, Gambhir SS, Miller JF.
Bioluminescent imaging of melanoma in live mice. J Invest Dermatol. 2005;125:159-165
Crawford MA, Zhu Y, Green CS, Burdick MD, Sanz P, Alem F, O'Brien AD, Mehrad B, Strieter RM, Hughes MA.
Antimicrobial effects of interferon-inducible cxc chemokines against bacillus anthracis spores and bacilli▿.
Infection and Immunity. 2009;77:1664-1678
Creamer BA, Triplett AA, Wagner KU. Longitudinal analysis of mammogenesis using a novel tet-inducible mouse
model and in vivo imaging. Genesis. 2009;47:234-245
Cresce Avon W, Dandu R, Burger A, Cappello J, Ghandehari H. Characterization and real-time imaging of gene
expression of adenovirus embedded silk-elastinlike protein polymer hydrogels. Mol Pharm. 2008;5:891-897
Crettaz J, Berraondo P, Mauleón I, Ochoa L, Shankar V, Barajas M, van Rooijen N, Kochanek S, Qian C, Prieto J.
Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in
mice. Hepatology. 2006;44:623-632
Creusot RJ, Yaghoubi SS, Kodama K, Dang DN, Dang VH, Breckpot K, Thielemans K, Gambhir SS, Fathman CG.
Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express il-4 in nod mice.
Clin Immunol. 2008
Croker BA, Lawson BR, Berger M, Eidenschenk C, Blasius AL, Moresco EMY, Sovath S, Cengia L, Shultz LD,
Theofilopoulos AN, Pettersson S, Beutler BA. Inflammation and autoimmunity caused by a shp1 mutation
depend on il-1, myd88, and a microbial trigger. Proceedings of the National Academy of Sciences of the United
States of America. 2008;105:15028-15033
Cronin M, Morrissey D, Rajendran S, El Mashad SM, van Sinderen D, O'Sullivan GC, Tangney M. Orally
administered bifidobacteria as vehicles for delivery of agents to systemic tumors. Mol Ther. 2010;18:1397-1407
Cronin M, Sleator RD, Hill C, Fitzgerald GF, van Sinderen D. Development of a luciferase-based reporter system
to monitor bifidobacterium breve ucc2003 persistence in mice. BMC Microbiol. 2008;8:161
Cruickshank SM, Wakenshaw L, Cardone J, Howdle PD, Murray PJ, Carding SR. Evidence for the involvement of
nod2 in regulating colonic epithelial cell growth and survival. World J Gastroenterol. 2008;14:5834-5841
Crull K, Bumann D, Weiss S. Influence of infection route and virulence factors on colonization of solid tumors
by salmonella enterica serovar typhimurium. FEMS immunology and medical microbiology. 2011;62:75-83
Cu Y, Booth CJ, Saltzman WM. In vivo distribution of surface-modified plga nanoparticles following
intravaginal delivery. Journal of controlled release : official journal of the Controlled Release Society. 2011
Cubillos-Ruiz JR, Engle X, Scarlett UK, Martinez D, Barber A, Elgueta R, Wang L, Nesbeth Y, Durant Y, Gewirtz
AT, Sentman CL, Kedl R, Conejo-Garcia JR. Polyethylenimine-based sirna nanocomplexes reprogram tumor-
462.
463.
464.
465.
466.
467.
468.
469.
470.
471.
472.
473.
474.
475.
476.
477.
478.
479.
480.
481.
482.
483.
484.
485.
associated dendritic cells via tlr5 to elicit therapeutic antitumor immunity. Journal of Clinical Investigation.
2009;119:2231-2244
Cui K, Xu X, Zhao H, Wong ST. A quantitative study of factors affecting in vivo bioluminescence imaging.
Luminescence. 2008
Cui Y, Zhang H, Meadors J, Poon R, Guimond M, Mackall CL. Harnessing the physiology of lymphopenia to
support adoptive immunotherapy in lymphoreplete hosts. Blood. 2009;114:3831-3840
Curie T, Mongrain V, Dorsaz S, Maret S, Emmenegger Y, Franken P. Homeostatic and circadian contribution to
changes in per2 protein in whole living mice. Sleep. 2009;32:A140
Curie T, Mongrain V, Dorsaz S, Maret S, Emmenegger Y, Franken P. Imaging the homeostatic and circadian
contributions in per2 protein in living mice. Neuropsychobiology. 2009;59:249-250
Curtin JF, King GD, Candolfi M, Greeno RB, Kroeger KM, Lowenstein PR, Castro MG. Combining cytotoxic and
immune-mediated gene therapy to treat brain tumors. Curr Top Med Chem. 2005;5:1151-1170
Curtis A, Calabro K, Galarneau JR, Bigio IJ, Krucker T. Temporal variations of skin pigmentation in c57bl/6 mice
affect optical bioluminescence quantitation. Molecular imaging and biology : MIB : the official publication of
the Academy of Molecular Imaging. 2010
Cybulski RJ, Sanz P, Alem F, Stibitz S, Bull RL, O'Brien AD. Four superoxide dismutases contribute to bacillus
anthracis virulence and provide spores with redundant protection from oxidative stress▿†. Infection and
Immunity. 2009;77:274-285
Daadi MM, Davis AS, Arac A, Li Z, Maag AL, Bhatnagar R, Jiang K, Sun G, Wu JC, Steinberg GK. Human neural
stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain
injury. Stroke. 2010;41:516-523
Daadi MM, Li Z, Arac A, Grueter BA, Sofilos M, Malenka RC, Wu JC, Steinberg GK. Molecular and magnetic
resonance imaging of human embryonic stem cell–derived neural stem cell grafts in ischemic rat brain. Mol Ther.
2009;17:1282-1291
Daadi MM, Li Z, Arac A, Grueter BA, Sofilos M, Malenka RC, Wu JC, Steinberg GK. Molecular and magnetic
resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain. Molecular
therapy : the journal of the American Society of Gene Therapy. 2009;17:1282-1291
Dai T, Tegos GP, Burkatovskaya M, Castano AP, Hamblin MR. Chitosan acetate bandage as a topical
antimicrobial dressing for infected burns▿. Antimicrobial Agents and Chemotherapy. 2009;53:393-400
Dai T, Tegos GP, Zhiyentayev T, Mylonakis E, Hamblin MR. Photodynamic therapy for methicillin-resistant
staphylococcus aureus infection in a mouse skin abrasion model. Lasers in Surgery and Medicine. 2010;42:38
Dai Y, Chen S, Wang L, Pei XY, Funk VL, Kramer LB, Dent P, Grant S. Disruption of ikk-mediated rela serine 536
phosphorylation sensitizes human multiple myeloma cells to hdac inhibitors. The Journal of biological
chemistry. 2011
Dai Y, Liu M, Tang W, DeSano J, Burstein E, Davis M, Pienta K, Lawrence T, Xu L. Molecularly targeted
radiosensitization of human prostate cancer by modulating inhibitor of apoptosis. Clinical Cancer Research.
2008;14:7701-7710
Dalgard CL, Van Quill KR, O'Brien JM. Evaluation of the in vitro and in vivo antitumor activity of histone
deacetylase inhibitors for the therapy of retinoblastoma. Clin Cancer Res. 2008;14:3113-3123
Dallas NA, Gray MJ, Xia L, Fan F, van Buren G, 2nd, Gaur P, Samuel S, Lim SJ, Arumugam T, Ramachandran V,
Wang H, Ellis LM. Neuropilin-2-mediated tumor growth and angiogenesis in pancreatic adenocarcinoma. Clin
Cancer Res. 2008;14:8052-8060
Dalton J, Cruickshank S, Egan C, Mears R, Newton D, Andrew E, Lawrence B, Howell G, Else K, Gubbels M.
Intraepithelial [gamma][delta]+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in
response to infection. Gastroenterology. 2006;131:818-829
Dames P, Laner A, Maucksch C, Aneja M, Rudolph C. Targeting of the glucocorticoid hormone receptor with
plasmid DNA comprising glucocorticoid response elements improves nonviral gene transfer efficiency in the
lungs of mice. The Journal of Gene Medicine. 2007;9:820-829
Daneshvar H, Nelms J, Muhammad O, Jackson H, Tkach J, Davros W, Peterson T, Vogelbaum MA, Bruchez MP,
Toms SA. Imaging characteristics of zinc sulfide shell, cadmium telluride core quantum dots. Nanomed.
2008;3:21-29
Dang TT, Bratlie KM, Bogatyrev SR, Chen XY, Langer R, Anderson DG. Spatiotemporal effects of a controlledrelease anti-inflammatory drug on the cellular dynamics of host response. Biomaterials. 2011;32:4464-4470
Dangi-Garimella S, Yun J, Eves EM, Newman M, Erkeland SJ, Hammond SM, Minn AJ, Rosner MR. Raf kinase
inhibitory protein suppresses a metastasis signalling cascade involving lin28 and let-7. EMBO Journal.
2009;28:347-358
Danielsson A, Dzojic H, Nilsson B, Essand M. Increased therapeutic efficacy of the prostate-specific oncolytic
adenovirus ad[i/ppt-e1a] by reduction of the insulator size and introduction of the full-length e3 region. Cancer
Gene Ther. 2008;15:203-213
Danussi C, Coslovi A, Campa C, Mucignat MT, Spessotto P, Uggeri F, Paoletti S, Colombatti A. A newly
generated functional antibody identifies tn antigen as a novel determinant in the cancer cell–lymphatic
endothelium interaction. Glycobiology. 2009;19:1056-1067
Darabi R, Santos FN, Filareto A, Pan W, Koene R, Rudnicki MA, Kyba M, Perlingeiro RC. Assessment of the
myogenic stem cell compartment following transplantation of pax3/pax7-induced embryonic stem cell-derived
486.
487.
488.
489.
490.
491.
492.
493.
494.
495.
496.
497.
498.
499.
500.
501.
502.
503.
504.
505.
506.
507.
508.
509.
510.
progenitors. Stem cells. 2011;29:777-790
Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS. Tumor detection by
imaging proteolytic activity. Cancer Res. 2010;70:1505-1512
Darrasse-Jèze G, Bergot AS, Durgeau A, Billiard F, Salomon BL, Cohen JL, Bellier B, Podsypanina K, Klatzmann
D. Tumor emergence is sensed by self-specific cd44hi memory tregs that create a dominant tolerogenic
environment for tumors in mice. Journal of Clinical Investigation. 2009;119:2648-2662
Dart DA, Spencer-Dene B, Gamble SC, Waxman J, Bevan CL. Manipulating prohibitin levels provides evidence
for an in vivo role in androgen regulation of prostate tumours. Endocr Relat Cancer. 2009;16:1157-1169
Das R, Komorowski R, Hessner M, Subramanian H, Huettner C, Cua D, Drobyski W. Blockade of interleukin-23
signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graftversus-leukemia responses. Blood. 2010;115:5249
Dasmahapatra G, Lembersky D, Son MP, Attkisson E, Dent P, Fisher RI, Friedberg JW, Grant S. Carfilzomib
interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo.
Mol Cancer Ther. 2011
Daugimont L, Vandermeulen G, Defresne F, Bouzin C, Mir LM, Bouquet C, Feron O, Preat V. Antitumoral and
antimetastatic effect of antiangiogenic plasmids in b16 melanoma: Higher efficiency of the recombinant
disintegrin domain of adam 15. European journal of pharmaceutics and biopharmaceutics : official journal of
Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2011;78:314-319
Davies LA, Hannavy K, Davies N, Pirrie A, Coffee RA, Hyde SC, Gill DR. Electrohydrodynamic comminution: A
novel technique for the aerosolisation of plasmid DNA. Pharmaceutical Research. 2005;22:1294-1304
Davies SJ, Smith SJ, Lim K, Zhang H, Purchio AF, McKerrow JH, West DB. In vivo imaging of tissue eosinophilia
and eosinopoietic responses to schistosome worms and eggs. International Journal for Parasitology.
2005;35:851-859
Davila HH, Magee TR, Rajfer J, Gonzalez-Cadavid NF. Gene therapy with the inducible nitric oxide synthase
(inos) cdna regresses the fibrotic plaque in an animal model of peyronie's disease. Journal of Urology.
2004;171:330
Davila HH, Magee TR, Vernet D, Rajfer J, Gonzalez-Cadavid NF. Gene transfer of inducible nitric oxide synthase
complementary DNA regresses the fibrotic plaque in an animal model of peyronie's disease. Biology of
Reproduction. 2004;71:1568-1577
Day CP, Carter J, Bonomi C, Esposito D, Crise B, Ortiz-Conde B, Hollingshead M, Merlino G. Lentivirus-mediated
bifunctional cell labeling for in vivo melanoma study. Pigment Cell Melanoma Res. 2009;22:283-295
Day E, Thompson P, Zhang L, Lewinski N, Ahmed N, Drezek R, Blaney S, West J. Nanoshell-mediated
photothermal therapy improves survival in a murine glioma model. Journal of Neuro-Oncology. 2010:1-9
De A, Gambhir S. Noninvasive imaging of protein-protein interactions from live cells and living subjects using
bioluminescence resonance energy transfer. The FASEB Journal. 2005:05
De A, Lewis XZ, Gambhir SS. Noninvasive imaging of lentiviral-mediated reporter gene expression in living
mice. Mol Ther. 2003;7:681-691
De A, Loening A, Gambhir S. An improved bioluminescence resonance energy transfer strategy for imaging
intracellular events in single cells and living subjects. Cancer Res. 2007;67:7175
De A, Yaghoubi SS, Gambhir SS. Applications of lentiviral vectors in noninvasive molecular imaging. Methods
Mol Biol. 2008;433:177-202
de Bruyn M, Wei Y, Wiersma VR, Samplonius DF, Klip HG, van der Zee AG, Yang B, Helfrich W, Bremer E. Cell
surface delivery of trail strongly augments the tumoricidal activity of t-cells. Clinical cancer research : an
official journal of the American Association for Cancer Research. 2011
de Heredia LL, Gengatharan A, Foster J, Mather S, Magoulas C. Bioluminescence imaging of the brain response to
acute inflammation in living c/ebp reporter mice. Neuroscience letters. 2011;497:134-138
De La Zerda A, Bodapati S, Teed R, Schipper ML, Keren S, Smith BR, Ng JST, Gambhir SS. A comparison between
time domain and spectral imaging systems for imaging quantum dots in small living animals. Molecular
Imaging and Biology. 2010;12:500-508
De Laporte L, Yang Y, Zelivyanskaya ML, Cummings BJ, Anderson AJ, Shea LD. Plasmid releasing multiple
channel bridges for transgene expression after spinal cord injury. Mol Ther. 2009;17:318-326
de Mare A, Lambeck AJ, Regts J, van Dam GM, Nijman HW, Snippe H, Wilschut J, Daemen T. Viral vector-based
prime-boost immunization regimens: A possible involvement of t-cell competition. Gene Ther.
2008;15:393-403
De Napoli IE, Scaglione S, Giannoni P, Quarto R, Catapano G. Mesenchymal stem cell culture in convectionenhanced hollow fibre membrane bioreactors for bone tissue engineering. Journal of Membrane Science.
2011;379:341-352
De Rijck J, Vandekerckhove L, Gijsbers R, Hombrouck A, Hendrix J, Vercammen J, Engelborghs Y, Christ F,
Debyser Z. Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits
human immunodeficiency virus replication▿. J Virol. 2006;80:11498-11509
de Vries NA, Bruggeman SW, Hulsman D, de Vries HI, Zevenhoven J, Buckle T, Hamans BC, Leenders WP, Beijnen
JH, van Lohuizen M, Berns AJ, van Tellingen O. Rapid and robust transgenic high-grade glioma mouse models
for therapy intervention studies. Clin Cancer Res. 2010;16:3431-3441
de Waard V, Bot I, de Jager SC, Talib S, Egashira K, de Vries MR, Quax PH, Biessen EA, van Berkel TJ. Systemic
511.
512.
513.
514.
515.
516.
517.
518.
519.
520.
521.
522.
523.
524.
525.
526.
527.
528.
529.
530.
531.
532.
533.
mcp1/ccr2 blockade and leukocyte specific mcp1/ccr2 inhibition affect aortic aneurysm formation differently.
Atherosclerosis. 2010
Deane NG, Manning HC, Foutch AC, Washington MK, Aronow BJ, Bornhop DJ, Coffey RJ. Targeted imaging of
colonic tumors in smad3-/- mice discriminates cancer and inflammation. Mol Cancer Res. 2007;5:341-349
Debus ES, Larena-Avellaneda A, Dietz UA, Siegel R, Gattenlohner S, Franke S. Silicone-covered polyester
prosthesis. Results following subrenal aortic repair in a dog model. Gefasschirurgie. 2002;7:65-69
Deckers M, van Dinther M, Buijs J, Que I, Lowik C, van der Pluijm G, ten Dijke P. The tumor suppressor smad4 is
required for transforming growth factor {beta}-induced epithelial to mesenchymal transition and bone metastasis
of breast cancer cells. Cancer Res. 2006;66:2202-2209
Decrausaz L, Gonçalves A, Domingos-Pereira S, Pythoud C, Stehle J, Schiller J, Jichlinski P, Nardelli-Haefliger D.
A novel mucosal orthotopic murine model of human papillomavirus-associated genital cancers. International
Journal of Cancer. 2010
Degenfeld G, Wehrman TS, Blau HM. Imaging beta-galactosidase activity in vivo using sequential reporterenzyme luminescence. Bioluminescence. 2009:249-259.
Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y, Nelson
DA, Jin S, White E. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and
tumorigenesis. Cancer Cell. 2006;10:51-64
Del Pozo JL, Rouse MS, Euba G, Kang CI, Mandrekar JN, Steckelberg JM, Patel R. The electricidal effect is active
in an experimental model of staphylococcus epidermidis chronic foreign body osteomyelitis ▿. Antimicrobial
Agents and Chemotherapy. 2009;53:4064-4068
del Pozo JL, Rouse MS, Mandrekar JN, Sampedro MF, Steckelberg JM, Patel R. Effect of electrical current on the
activities of antimicrobial agents against pseudomonas aeruginosa, staphylococcus aureus, and staphylococcus
epidermidis biofilms▿. Antimicrobial Agents and Chemotherapy. 2009;53:35-40
del Pozo JL, Rouse MS, Mandrekar JN, Steckelberg JM, Patel R. The electricidal effect: Reduction of
staphylococcus and pseudomonas biofilms by prolonged exposure to low-intensity electrical current.
Antimicrob Agents Chemother. 2009;53:41-45
Della Torre S, Biserni A, Rando G, Monteleone G, Ciana P, Komm B, Maggi A. The conundrum of estrogen
receptor oscillatory activity in the search for an appropriate hormone replacement therapy. Endocrinology.
2011;152:2256-2265
Dellacasa-Lindberg I, Hitziger N, Barragan A. Localized recrudescence of toxoplasma infections in the central
nervous system of immunocompromised mice assessed by in vivo bioluminescence imaging. Microbes Infect.
2007;9:1291-1298
Demidova TN, Gad F, Zahra T, Francis KP, Hamblin MR. Monitoring photodynamic therapy of localized
infections by bioluminescence imaging of genetically engineered bacteria. Journal of Photochemistry and
Photobiology B: Biology. 2005;81:15-25
Denker SP, Barber DL. Cell migration requires both ion translocation and cytoskeletal anchoring by the na-h
exchanger nhe1. Journal of Cell Biology. 2002;159:1087-1096
Dennery P, Visner G, Weng Y, Nguyen X, Lu F, Zander D, Yang G. Resistance to hyperoxia with heme oxygenase-1
disruption: Role of iron. Free Radical Biology and Medicine. 2003;34:124-133
Dennis A, Kudo T, Kruidenier L, Girard F, Crepin VF, MacDonald TT, Frankel G, Wiles S. The p50 subunit of nfkappab is critical for in vivo clearance of the noninvasive enteric pathogen citrobacter rodentium. Infect Immun.
2008;76:4978-4988
Dentin R, Hedrick S, Xie J, Yates J, 3rd, Montminy M. Hepatic glucose sensing via the creb coactivator crtc2.
Science. 2008;319:1402-1405
Dentin R, Liu Y, Koo SH, Hedrick S, Vargas T, Heredia J, Yates J, 3rd, Montminy M. Insulin modulates
gluconeogenesis by inhibition of the coactivator torc2. Nature. 2007;449:366-369
Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R,
Hingorani SR, Mahmood U, Rustgi AK. N-cadherin and keratinocyte growth factor receptor mediate the
functional interplay between ki-rasg12v and p53v143a in promoting pancreatic cell migration, invasion, and
tissue architecture disruption. Molecular and Cellular Biology. 2006;26:4185-4200
Deroose C, De A, Loening A, Chow P, Ray P, Chatziioannou A, Gambhir S. Multimodality imaging of tumor
xenografts and metastases in mice with combined small-animal pet, small-animal ct, and bioluminescence
imaging. Journal of Nuclear Medicine. 2007;48:295
Deroose C, Reumers V, Gijsbers R, Bormans G, Debyser Z, Mortelmans L, Baekelandt V. Noninvasive monitoring
of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescen ce imaging.
Molecular Therapy. 2006;14:423-431
Deuse T, Peter C, Fedak PW, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen T, Stein W, Wu JC,
Robbins RC, Schrepfer S. Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes
mesenchymal stem cell-based myocardial salvage after acute myocardial infarction. Circulation.
2009;120:S247-254
Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk H-D, Reichenspurner H,
Robbins RC, Schrepfer S. Immunogenicity and immunomodulatory properties of umbilical cord lining
mesenchymal stem cells. Cell Transplantation. 2011;20:655-667
Dewals B, Myster F, Palmeira L, Gillet L, Ackermann M, Vanderplasschen A. Ex vivo bioluminescence detection
534.
535.
536.
537.
538.
539.
540.
541.
542.
543.
544.
545.
546.
547.
548.
549.
550.
551.
552.
553.
554.
555.
556.
of alcelaphine herpesvirus 1 infection during malignant catarrhal fever. J Virol. 2011;85:6941-6954
DeWever J, Frérart F, Bouzin C, Baudelet C, Ansiaux R, Sonveaux P, Gallez B, Dessy C, Feron O. Caveolin-1 is
critical for the maturation of tumor blood vessels through the regulation of both endothelial tube formation and
mural cell recruitment. American Journal of Pathology. 2007;171:1619-1628
Dey D, Inayathullah M, Lee AS, LeMieux MC, Zhang X, Wu Y, Nag D, De Almeida PE, Han L, Rajadas J, Wu JC.
Efficient gene delivery of primary human cells using peptide linked polyethylenimine polymer hybrid.
Biomaterials. 2011;32:4647-4658
Dhaliwal K, Alexander L, Escher G, Unciti-Broceta A, Jansen M, McDonald N, Cardenas-Maestre JM, SanchezMartin R, Simpson J, Haslett C, Bradley M. Multi-modal molecular imaging approaches to detect primary cells in
preclinical models. Faraday discussions. 2011;149:107-114; discussion 137-157
Dhar SK, Xu Y, Noel T, Clair DK. Chronic exposure to 12-o-tetradecanoylphorbol-13-acetate represses sod2
induction in vivo: The negative role of p50. Carcinogenesis. 2007;28:2605-2613
Di Cristina M, Marocco D, Galizi R, Proietti C, Spaccapelo R, Crisanti A. Temporal and spatial distribution of
toxoplasma gondii differentiation into bradyzoites and tissue cyst formation in vivo. Infect Immun.
2008;76:3491-3501
Di Pasquale G, Ostedgaard LS, Welsh MJ, Chiorini JA. Baav mediated transduction of lung epithelia in vitro and
in vivo. Molecular Therapy. 2009;17:S320
Di Stasi A, De Angelis B, Rooney CM, Zhang L, Mahendravada A, Foster AE, Heslop HE, Brenner MK, Dotti G,
Savoldo B. T lymphocytes coexpressing ccr4 and a chimeric antigen receptor targeting cd30 have improved
homing and antitumor activity in a hodgkin tumor model. Blood. 2009;113:6392-6402
Di Stasi A, Dotti G, Foster A, Zhang L, Heslop H, Rooney C, Brenner MK, Savoldo B. Improved homing of
antigen-specific t cells to hodgkin's disease (hd) tumor cells by forced expression of ccr4 receptor. Blood.
2006;108:143A
Diagaradjane P, Orenstein-Cardona JM, N EC-C, Deorukhkar A, Shentu S, Kuno N, Schwartz DL, Gelovani JG,
Krishnan S. Imaging epidermal growth factor receptor expression in vivo: Pharmacokinetic and biodistribution
characterization of a bioconjugated quantum dot nanoprobe. Clin Cancer Res. 2008;14:731-741
Diamond P, Labrinidis A, Martin SK, Farrugia AN, Gronthos S, Bik To L, Fujii N, O'Loughlin PD, Evdokiou A,
Zannettino AC. Targeted disruption of the cxcl12/cxcr4 axis inhibits osteolysis in a murine model of myelomaassociated bone loss. J Bone Miner Res. 2009
Diavatopoulos DA, Short KR, Price JT, Wilksch JJ, Brown LE, Briles DE, Strugnell RA, Wijburg OL. Influenza a
virus facilitates streptococcus pneumoniae transmission and disease. Faseb J. 2010;24:1789-1798
Dickson P, Hamner B, Ng C, Hall M, Zhou J, Hargrove P, McCarville M, Davidoff A. In vivo bioluminescence
imaging for early detection and monitoring of disease progression in a murine model of neuroblastoma. Journal
of Pediatric Surgery. 2007;42:1172-1179
Dickson PV, Hamner JB, Burger RA, Garcia E, Ouma AA, Kim SU, Ng CY, Gray JT, Aboody KS, Danks MK,
Davidoff AM. Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of
interferon-beta and restricts tumor growth in a murine model of disseminated neuroblastoma. J Pediatr Surg.
2007;42:48-53
Dickson PV, Hamner JB, Cauthen LA, Ng CY, McCarville MB, Davidoff AM. Efficacy of zoledronate against
neuroblastoma. Surgery. 2006;140:227-235
Dickson PV, Hamner JB, Streck CJ, Ng CY, McCarville MB, Calabrese C, Gilbertson RJ, Stewart CF, Wilson CM,
Gaber MW, Pfeffer LM, Skapek SX, Nathwani AC, Davidoff AM. Continuous delivery of ifn-beta promotes
sustained maturation of intratumoral vasculature. Mol Cancer Res. 2007;5:531-542
Dieguez-Hurtado R, Martin J, Martinez-Corral I, Martinez MD, Megias D, Olmeda D, Ortega S. A cre-reporter
transgenic mouse expressing the far-red fluorescent protein katushka. Genesis. 2011;49:36-45
Dierks C, Grbic J, Zirlik K, Beigi R, Englund NP, Guo GR, Veelken H, Engelhardt M, Mertelsmann R, Kelleher JF,
Schultz P, Warmuth M. Essential role of stromally induced hedgehog signaling in b-cell malignancies. Nature
medicine. 2007;13:944-951
Dierks C, Grbic J, Zirlik K, Mertelsmann RH, Warmuth M. Hedgehog pathway: A new target for b-cell lymphomas
and multiple myeloma. Blood. 2006;108:119A-120A
Dietrich N, Lienenklaus S, Weiss S, Gekara NO. Murine toll-like receptor 2 activation induces type i interferon
responses from endolysosomal compartments. PLoS ONE. 2010
Dietze A, Peng Q, Selbo PK, Kaalhus O, Müller C, Bown S, Berg K. Enhanced photodynamic destruction of a
transplantable fibrosarcoma using photochemical internalisation of gelonin. British Journal of Cancer.
2005;92:2004-2009
Dieye Y, Dyszel JL, Kader R, Ahmer BM. Systematic analysis of the regulation of type three secreted effectors in
salmonella enterica serovar typhimurium. BMC Microbiol. 2007;7:3
DiFeo A, Huang F, Sangodkar J, Terzo EA, Leake D, Narla G, Martignetti JA. Klf6-sv1 is a novel antiapoptotic
protein that targets the bh3-only protein noxa for degradation and whose inhibition extends survival in an
ovarian cancer model. Cancer Res. 2009;69:4733-4741
DiGiandomenico A, Rao J, Harcher K, Zaidi TS, Gardner J, Neely AN, Pier GB, Goldberg JB. Intranasal
immunization with heterologously expressed polysaccharide protects against multiple pseudomonas aeruginosa
infections. Proceedings of the National Academy of Sciences of the United States of America.
2007;104:4624-4629
557.
558.
559.
560.
561.
562.
563.
564.
565.
566.
567.
568.
569.
570.
571.
572.
573.
574.
575.
576.
577.
578.
579.
580.
581.
582.
583.
Dinca E, Sarkaria J, Schroeder M, Carlson B, Voicu R, Gupta N, Berger M, James C. Bioluminescence monitoring
of intracranial glioblastoma xenograft: Response to primary and salvage temozolomide therapy. Journal of
Neurosurgery: Pediatrics. 2007;107
Dinca EB, Lu KV, Sarkaria JN, Pieper RO, Prados MD, Haas-Kogan DA, Vandenberg SR, Berger MS, James CD. P53
small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma
xenografts. Cancer Res. 2008;68:10034-10039
Disson O, Grayo S, Huillet E, Nikitas G, Langa-Vives F, Dussurget O, Ragon M, Le Monnier A, Babinet C, Cossart
P, Lecuit M. Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis. Nature.
2008;455:1114-1118
Disson O, Nikitas G, Grayo S, Dussurget O, Cossart P, Lecuit M. Modeling human listeriosis in natural and
genetically engineered animals. Nat Protoc. 2009;4:799-810
Dobrenkov K, Olszewska M, Likar Y, Shenker L, Gunset G, Cai S, Pillarsetty N, Hricak H, Sadelain M, Ponomarev
V. Monitoring the efficacy of adoptively transferred prostate cancer-targeted human t lymphocytes with pet and
bioluminescence imaging. J Nucl Med. 2008;49:1162-1170
Dohlen G, Carlsen H, Blomhoff R, Thaulow E, Saugstad OD. Reoxygenation of hypoxic mice with 100% oxygen
induces brain nuclear factor-kappa b. Pediatr Res. 2005;58:941-945
Dohlen G, Odland HH, Carlsen H, Blomhoff R, Thaulow E, Saugstad OD. Antioxidant activity in the newborn
brain: A luciferase mouse model. Neonatology. 2008;93:125-131
Domm W, Brooks L, Chung HL, Feng C, Bowers WJ, Watson G, McGrath JL, Dewhurst S. Robust antigen-specific
humoral immune responses to sublingually delivered adenoviral vectors encoding hiv-1 env: Association with
mucoadhesion and efficient penetration of the sublingual barrier. Vaccine. 2011
Dommel MK, Frenzel E, Strasser B, Blöchinger C, Scherer S, Ehling-Schulz M. Identification of the main promoter
directing cereulide biosynthesis in emetic bacillus cereus and its application for real-time monitoring of ces
gene expression in foods▿†. Applied and Environmental Microbiology. 2010;76:1232-1240
Dong M, How T, Kirkbride KC, Gordon KJ, Lee JD, Hempel N, Kelly P, Moeller BJ, Marks JR, Blobe GC. The type
iii tgf-beta receptor suppresses breast cancer progression. J Clin Invest. 2007;117:206-217
Dong Z, Neiva KG, Jin T, Zhang Z, Hall DE, Mooney DJ, Polverini PJ, Nor JE. Quantification of human
angiogenesis in immunodeficient mice using a photon counting-based method. Biotechniques. 2007;43:73-77
Dorn DC, Kou CA, Png KJ, Moore MA. The effect of cantharidins on leukemic stem cells. Int J Cancer.
2009;124:2186-2199
Dorsey J, Mintz A, Tian X, Dowling M, Plastaras J, Dicker D, Kao G, El-Deiry W. Tumor necrosis factor–related
apoptosis-inducing ligand (trail) and paclitaxel have cooperative in vivo effects against glioblastoma
multiforme cells. Mol Cancer Ther. 2009;8:3285
Dortet L, Mostowy S, Louaka AS, Gouin E, Nahori MA, Wiemer EA, Dussurget O, Cossart P. Recruitment of the
major vault protein by inlk: A listeria monocytogenes strategy to avoid autophagy. PLoS pathogens.
2011;7:e1002168
Dothager RS, Goiffon RJ, Jackson E, Harpstrite S, Piwnica-Worms D. Cerenkov radiation energy transfer (cret)
imaging: A novel method for optical imaging of pet isotopes in biological systems PLoS ONE. 2010
Doubrovin M, Serganova I, Mayer-Kuckuk P, Ponomarev V, Blasberg RG. Multimodality in vivo moleculargenetic imaging. Bioconjugate Chemistry. 2004;15:1376-1388
Douma S, Van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E, Peeper DS. Suppression of anoikis and
induction of metastasis by the neurotrophic receptor trkb. Nature. 2004;430:1034-1039
Doyle KP, Cekanaviciute E, Mamer LE, Buckwalter MS. Tgfβ signaling in the brain increases with aging and
signals to astrocytes and innate immune cells in the weeks after stroke. J Neuroinflammation. 2010;7:62
Doyle KP, Cekanaviciute E, Mamer LE, Buckwalter MS. Tgfbeta signaling in the brain increases with aging and
signals to astrocytes and innate immune cells in the weeks after stroke. Journal of neuroinflammation.
2010;7:62
Doyle TC, Burns SM, Contag CH. In vivo bioluminescence imaging for integrated studies of infection. Cellular
Microbiology. 2004;6:303-317
Doyle TC, Hansen JE, Reisler E. Tryptophan fluorescence of yeast actin resolved via conserved mutations.
Biophysical Journal. 2001;80:427-434
Doyle TC, Nawotka KA, Kawahara CB, Francis KP, Contag PR. Visualizing fungal infections in living mice using
bioluminescent pathogenic candida albicans strains transformed with the firefly luciferase gene. Microbial
Pathogenesis. 2006;40:82-90
Doyle TC, Nawotka KA, Purchio AF, Akin AR, Francis KP, Contag PR. Expression of firefly luciferase in candida
albicans and its use in the selection of stable transformants. Microbial Pathogenesis. 2006;40:69-81
Doyle TC, Reisler E. Insights into actomyosin interactions from actin mutations. Results and Problems in Cell
Differentiation. 2002;36:31-49
Dragulescu-Andrasi A, Liang G, Rao J. In vivo bioluminescence imaging of furin activity in breast cancer cells
using bioluminogenic substrates. Bioconjugate Chemistry. 2009;20:1660-1666
Drake JM, Gabriel C, L. , Henry M, D. . Assessing tumor growth and distribution in a model of prostate cancer
metastasis using bioluminescence imaging. Clinical and Experimental Metastasis. 2005;V22:674-684
Drake JM, Strohbehn G, Bair TB, Moreland JG, Henry MD. Zeb1 enhances transendothelial migration and
represses the epithelial phenotype of prostate cancer cells. Molecular Biology of the Cell. 2009;20:2207-2217
584.
585.
586.
587.
588.
589.
590.
591.
592.
593.
594.
595.
596.
597.
598.
599.
600.
601.
602.
603.
604.
605.
606.
607.
608.
609.
610.
Drury LJ, Wendt MK, Dwinell MB. Cxcl12 chemokine expression and secretion regulates colorectal carcinoma
cell anoikis through bim-mediated intrinsic apoptosis. PLoS One. 2010;5
Du J, Zhao F, Zhou y, Yan H, Duan X-G, Liang S-q, Wang Y-l, Wang X-h, Peng J-c, Zhan L-s. Bioluminescence
imaging allows monitoring hepatitis c virus core protein inhibitors in mice. PLoS ONE. 2010
Du J, Zhou Y, Fu QX, Gong WL, Zhao F, Peng JC, Zhan LS. Bioluminescence imaging of hepatitis b virus enhancer
and promoter activities in mice. FEBS Lett. 2008;582:3552-3556
Du YCN, Klimstra DS, Varmus H. Activation of pymt in β cells induces irreversible hyperplasia, but oncogenedependent acinar cell carcinomas when activated in pancreatic progenitors. PLoS One. 2009;4
Duan Y, Catana A, Meng Y, Yamamoto N, He S, Gupta S, Gambhir SS, Zern MA. Differentiation and enrichment of
hepatocyte-like cells from human embryonic stem cells in vitro and in vivo. Stem Cells. 2007;25:3058-3068
Dubach JM, Lim E, Zhang N, Francis KP, Clark H. In vivo sodium concentration continuously monitored with
fluorescent sensors. Integr Biol (Camb). 2010;3:142-148
Dubernard G, Oster M, Chareyre F, Antoine M, Rouzier R, Uzan S, Aractingi S, Khosrotehrani K. Increased fetal
cell microchimerism in high grade breast carcinomas occurring during pregnancy. Int J Cancer.
2009;124:1054-1059
Dubikovskaya EA, Thorne SH, Pillow TH, Contag CH, Wender PA. Overcoming multidrug resistance of smallmolecule therapeutics through conjugation with releasable octaarginine transporters. Proceedings of the
National Academy of Sciences of the United States of America. 2008;105:12128-12133
Duda J, Karimi M, Negrin RS, Contag CH. Methods for imaging cell fates in hematopoiesis. Methods Mol Med.
2007;134:17-34
Dugger KJ, Zinn KR, Weaver C, Bullard DC, Barnum SR. Effector and suppressor roles for lfa-1 during the
development of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 2009;206:22-27
Duignan IJ, Corcoran E, Pennello A, Plym MJ, Amatulli M, Claros N, Iacolina M, Youssoufian H, Witte L,
Samakoglu S, Schwartz J, Surguladze D, Tonra JR. Pleiotropic stromal effects of vascular endothelial growth
factor receptor 2 antibody therapy in renal cell carcinoma models. Neoplasia. 2011;13:49-59
Duiker EW, de Vries EG, Mahalingam D, Meersma GJ, Boersma-van Ek W, Hollema H, Lub-de Hooge MN, van Dam
GM, Cool RH, Quax WJ, Samali A, van der Zee AG, de Jong S. Enhanced antitumor efficacy of a dr5-specific trail
variant over recombinant human trail in a bioluminescent ovarian cancer xenograft model. Clin Cancer Res.
2009;15:2048-2057
Dumitru CD, Antonysamy MA, Gorski KS, Johnson DD, Reddy LG, Lutterman JL, Piri MM, Proksch J, McGurran
SM, Egging EA, Cochran FR, Lipson KE, Tomai MA, Gullikson GW. Nk1.1+ cells mediate the antitumor effects of
a dual toll-like receptor 7/8 agonist in the disseminated b16-f10 melanoma model. Cancer Immunol Immunother.
2009;58:575-587
Dumont N, Crawford YG, Sigaroudinia M, Nagrani SS, Wilson MB, Buehring GC, Turashvili G, Aparicio S,
Gauthier ML, Fordyce CA, McDermott KM, Tlsty TD. Human mammary cancer progression model recapitulates
methylation events associated with breast premalignancy. Breast Cancer Res. 2009;11:R87
Dunay IR, Chan WC, Haynes RK, Sibley LD. Artemisone and artemiside control acute and reactivated
toxoplasmosis in a murine model▿. Antimicrobial Agents and Chemotherapy. 2009;53:4450-4456
Dunay IR, Sibley LD. Inflammatory monocytes but not neutrophils are necessary to control infection with
toxoplasma gondii in mice. Infect Immun. 2010
Dunkle R. Role of image informatics in accelerating drug discovery and development. Drug Discovery
WorldWinter 2003/2004. 2003;4:75
Dunn CA, Jin Q, Taba M, Jr., Franceschi RT, Bruce Rutherford R, Giannobile WV. Bmp gene delivery for alveolar
bone engineering at dental implant defects. Molecular Therapy. 2005;11:294-299
Durai M, Krueger C, Ye Z, Cheng L, Mackensen A, Oelke M, Schneck JP. In vivo functional efficacy of tumorspecific t cells expanded using hla-ig based artificial antigen presenting cells (aapc). Cancer Immunology,
Immunotherapy. 2009;58:209-220
Duran-Struuck R, Tawara I, Lowler K, Clouthier SG, Weisiger E, Rogers C, Luker G, Kumanogoh A, Liu C, Ferrara
JL, Reddy P. A novel role for the semaphorin sema4d in the induction of alloresponses. Biology of Blood and
Marrow Transplantation. 2007;13:1294-1303
Durando X, Thivat E, Demidem A, Madelmont J, Chollet P. New approches in advanced melanoma treated by
nitrosourea. Journal of Immunotherapy. 2004;27:S52
Dussmann P, Pagel JI, Vogel S, Magnusson T, Zimmermann R, Wagner E, Schaper W, Ogris M, Deindl E. Live in
vivo imaging of egr-1 promoter activity during neonatal development, liver regeneration and wound healing.
BMC developmental biology. 2011;11:28
Duysen EG, Lockridge O. Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected
with near infrared dye labeled butyrylcholinesterase. Chemico-Biological Interactions. 2008;175:119-124
Dydensborg AB, Rose AA, Wilson BJ, Grote D, Paquet M, Giguere V, Siegel PM, Bouchard M. Gata3 inhibits
breast cancer growth and pulmonary breast cancer metastasis. Oncogene. 2009;28:2634-2642
Dyer MA, Rodriguez-Galindo C, Wilson MW. Use of preclinical models to improve treatment of retinoblastoma.
PLoS Med. 2005;2
Dzojic H, Cheng W, Essand M. Two-step amplification of the human ppt sequence provides specific gene
expression in an immunocompetent murine prostate cancer model. Cancer Gene Therapy. 2006;14:233-240
Ebos JM, Lee CR, Bogdanovic E, Alami J, Van Slyke P, Francia G, Xu P, Mutsaers AJ, Dumont DJ, Kerbel RS.
611.
612.
613.
614.
615.
616.
617.
618.
619.
620.
621.
622.
623.
624.
625.
626.
627.
628.
629.
630.
631.
632.
633.
634.
635.
Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor
receptor-2 levels as a surrogate biomarker for tumor growth. Cancer Res. 2008;68:521-529
Echchannaoui H, Frei K, Schnell C, Leib SL, Zimmerli W, Landmann R. Toll-like receptor 2-deficient mice are
highly susceptible to streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced
inflammation. Journal of Infectious Diseases. 2002;186:798-806
Echchannaoui H, Frei K, Schnell C, Letiembre M, Adachi Y, Landmann R. Cd14 deficiency leads to early death in
pneumococcal meningitis due to a high mip-2, cxcr2, neutrophil transmigration and inflammation. Role of the
pattern recognition receptors Toll-like receptor 2 and CD14 in murine pneumococcal meningitis. 2004:61
Echchgadda I, Chang TH, Sabbah A, Bakri I, Ikeno Y, Hubbard GB, Chatterjee B, Bose S. Oncolytic targeting of
androgen-sensitive prostate tumor by the respiratory syncytial virus (rsv): Consequences of deficient interferondependent antiviral defense. BMC cancer. 2011;11:43
Edgington LE, Berger AB, Blum G, Albrow VE, Paulick MG, Lineberry N, Bogyo M. Noninvasive optical imaging
of apoptosis by caspase-targeted activity-based probes. Nat Med. 2009;15:967-973
Edinger M, Cao YA, Hornig YS, Jenkins DE, Verneris MR, Bachmann MH, Negrin RS, Contag CH. Advancing
animal models of neoplasia through in vivo bioluminescence imaging. European Journal of Cancer.
2002;38:2128-2136
Edinger M, Cao YA, Verneris MR, Bachmann MH, Contag CH, Negrin RS. Revealing lymphoma growth and the
efficacy of immune cell therapies using in vivo bioluminescence imaging. Blood. 2003;101:640-648
Edinger M, Sweeney TJ, Tucker AA, Olomu AB, Negrin RS, Contag CH. Noninvasive assessment of tumor cell
proliferation in animal models. Neoplasia. 1999;1:303-310
Eefting D, Grimbergen JM, De Vries MR, Van Weel V, Kaijzel EL, Que I, Moon RT, Lowik CW, Van Bockel JH,
Quax PH. Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering
rna. Hum Gene Ther. 2007
Eguchi A, Meade BR, Chang YC, Fredrickson CT, Willert K, Puri N, Dowdy SF. Efficient sirna delivery into
primary cells by peptide transduction-dsrna binding domain (ptd-drbd) fusion protein. Nature Biotechnology.
2009;27:567-571
Ehrbar M, Zeisberger S, Raeber G, Hubbell J, Schnell C, Zisch A. The role of actively released fibrin-conjugated
vegf for vegf receptor 2 gene activation and the enhancement of angiogenesis. Biomaterials. 2008;29:1720-1729
El Kasmi KC, Qualls JE, Pesce JT, Smith AM, Thompson RW, Henao-Tamayo M, Basaraba RJ, Konig T, Schleicher
U, Koo MS, Kaplan G, Fitzgerald KA, Tuomanen EI, Orme IM, Kanneganti TD, Bogdan C, Wynn TA, Murray PJ.
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.
Nat Immunol. 2008;9:1399-1406
Elankumaran S, Chavan V, Qiao D, Shobana R, Moorkanat G, Biswas M, Samal SK. Type i interferon sensitive
recombinant newcastle disease virus for oncolytic virotherapy. J Virol. 2010
Elfinger M, Geiger J, Hasenpusch G, Uzgun S, Sieverling N, Aneja MK, Maucksch C, Rudolph C. Targeting of the
beta(2)-adrenoceptor increases nonviral gene delivery to pulmonary epithelial cells in vitro and lungs in vivo. J
Control Release. 2009;135:234-241
Elia L, Aurisicchio L, Facciabene A, Giannetti P, Ciliberto G, La Monica N, Palombo F. Cd4+cd25+ regulatory tcell-inactivation in combination with adenovirus vaccines enhances t-cell responses and protects mice from
tumor challenge. Cancer Gene Ther. 2007;14:201-210
Elinav E, Niv-Spector L, Katz M, Price TO, Ali M, Yacobovitz M, Solomon G, Reicher S, Lynch JL, Halpern Z,
Banks WA, Gertler A. Pegylated leptin antagonist is a potent orexigenic agent: Preparation and mechanism of
activity. Endocrinology. 2009;150:3083-3091
Elinav E, Waks T, Eshhar Z. Redirection of regulatory t cells with predetermined specificity for the treatment of
experimental colitis in mice. Gastroenterology. 2008;134:2014-2024
Ellwood-Yen K, Wongvipat J, Sawyers C. Transgenic mouse model for rapid pharmacodynamic evaluation of
antiandrogens. Cancer Res. 2006;66:10513-10516
Elnekave M, Bivas-Benita M, Gillard GO, Sircar P, Hovav AH. A matter of timing: Unsynchronized antigen
expression and antigen presentation diminish secondary t cell responses. J Immunol. 2009;183:1013-1021
Emmett MS, Lanati S, Dunn DB, Stone OA, Bates DO. Ccr7 mediates directed growth of melanomas towards
lymphatics. Microcirculation. 2011;18:172-182
Engelsman AF, van der Mei HC, Busscher HJ, Ploeg RJ. Morphological aspects of surgical meshes as a risk factor
for bacterial colonization. Br J Surg. 2008;95:1051-1059
Engelsman AF, van der Mei HC, Francis KP, Busscher HJ, Ploeg RJ, van Dam GM. Real time noninvasive
monitoring of contaminating bacteria in a soft tissue implant infection model. J Biomed Mater Res B Appl
Biomater. 2009;88:123-129
Enjalbert B, Rachini A, Vediyappan G, Pietrella D, Spaccapelo R, Vecchiarelli A, Brown AJ, d'Enfert C. A
multifunctional, synthetic gaussia princeps luciferase reporter for live imaging of candida albicans infections.
Infect Immun. 2009
Equils O, Bulut Y, Simmons C, Kleinman M, McGregor J. Systemic maternal exposure to airborne pollution leads
to fetal and placental inflammation. American Journal of Obstetrics and Gynecology. 2009;201:S90
Evanko D. Bioluminescent quantum dots. Nat Meth. 2006;3:240-241
Evans L, Williams AS, Hayes AJ, Jones SA, Nowell M. Suppression of leukocyte infiltration and cartilage
degradation by selective inhibition of pre-b cell colony-enhancing factor/visfatin/nicotinamide
636.
637.
638.
639.
640.
641.
642.
643.
644.
645.
646.
647.
648.
649.
650.
651.
652.
653.
654.
655.
656.
657.
658.
659.
660.
phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced
arthritis. Arthritis and rheumatism. 2011;63:1866-1877
Everhart M, Han W, Sherrill T, Arutiunov M, Polosukhin V, Burke J, Sadikot R, Christman J, Yull F, Blackwell T.
Duration and intensity of nf-{kappa} b activity determine the severity of endotoxin-induced acute lung injury.
The Journal of Immunology. 2006;176:4995
Evgin L, Vaha-Koskela M, Rintoul J, Falls T, Le Boeuf F, Barrett JW, Bell JC, Stanford MM. Potent oncolytic
activity of raccoonpox virus in the absence of natural pathogenicity. Mol Ther. 2010
Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wang XC, Maclellan WR, Crooks GM.
Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly.
Stem Cells Dev. 2009;18:919-928
Excoffon K, Koerber JT, Dickey DD, Murtha M, Keshavjee S, Kaspar BK, Zabner J, Schaffer DV. Directed evolution
of adeno-associated virus to an infectious respiratory virus. Proceedings of the National Academy of Sciences of
the United States of America. 2009;106:3865-3870
Eyler CE, Wu Q, Yan K, Macswords JM, Chandler-Militello D, Misuraca KL, Lathia JD, Forrester MT, Lee J, Stamler
JS, Goldman SA, Bredel M, McLendon RE, Sloan AE, Hjelmeland AB, Rich JN. Glioma stem cell proliferation and
tumor growth are promoted by nitric oxide synthase-2. Cell. 2011;146:53-66
Ezhilarasan R, Jadhav U, Mohanam I, Rao JS, Gujrati M, Mohanam S. The hemopexin domain of mmp-9 inhibits
angiogenesis and retards the growth of intracranial glioblastoma xenograft in nude mice. International Journal
of Cancer. 2009;124:306-315
Falk K, Sedgley C. The influence of preparation size on the mechanical efficacy of root canal irrigation in vitro.
Journal of Endodontics. 2005;31:742-745
Fan S, Maguire CA, Ramirez SH, Bradel-Tretheway B, Sapinoro R, Sui Z, Chakraborty-Sett S, Dewhurst S. Valproic
acid enhances gene expression from viral gene transfer vectors. J Virol Methods. 2005;125:23-33
Fan X, Ren P, Dhal S, Bejerano G, Goodman SB, Druzin ML, Gambhir SS, Nayak NR. Noninvasive monitoring of
placenta-specific transgene expression by bioluminescence imaging. PloS one. 2011;6:e16348
Fang F, Flynn S, Li Y, Claesson MJ, van Pijkeren JP, Collins JK, van Sinderen D, O'Toole PW. Characterization of
endogenous plasmids from lactobacillus salivarius ucc118. Appl Environ Microbiol. 2008;74:3216-3228
Feeley B, Conduah A, Sugiyama O, Krenek L, Chen I, Lieberman J. In vivo molecular imaging of adenoviral
versus lentiviral gene therapy in two bone formation models. Journal of Orthopaedic Research.
2006;24:1709-1721
Fei P, Wang W, Kim SH, Wang S, Burns TF, Sax JK, Buzzai M, Dicker DT, McKenna WG, Bernhard EJ, El-Deiry WS.
Bnip3l is induced by p53 under hypoxia, and its knockdown promotes tumor growth. Cancer Cell.
2004;6:597-609
Fein DE, Limberis MP, Maloney SF, Heath JM, Wilson JM, Diamond SL. Cationic lipid formulations alter the in
vivo tropism of aav2/9 vector in lung. Mol Ther. 2009;17:2078-2087
Feldman D, Chauhan V, Koong A. The unfolded protein response: A novel component of the hypoxic stress
response in tumors. Molecular Cancer Research. 2005;3:597
Fels DR, Ye J, Segan AT, Kridel SJ, Spiotto M, Olson M, Koong AC, Koumenis C. Preferential cytotoxicity of
bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer
Res. 2008;68:9323-9330
Feng B, Tomizawa K, Michiue H, Han XJ, Miyatake SI, Matsui H. Development of a bifunctional immunoliposome
system for combined drug delivery and imaging in vivo. Biomaterials. 2010
Feng M, Zhang J, Anver M, Hassan R, Ho M. In vivo imaging of human malignant mesothelioma grown
orthotopically in the peritoneal cavity of nude mice. Journal of Cancer. 2011;2:123-131
Feng YX, Wang T, Deng YZ, Yang P, Li JJ, Guan DX, Yao F, Zhu YQ, Qin Y, Wang H, Li N, Wu MC, Wang HY, Wang
XF, Cheng SQ, Xie D. Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in
an orthotopic mouse model. Hepatology. 2011;53:483-492
Ferguson JW, Thoma BS, Mikesh MF, Kramer RH, Bennett KL, Purchio A, Bellard BJ, LeBaron RG. The
extracellular matrix protein (beta)ig-h3 is expressed at myotendinous junctions and supports muscle cell
adhesion. Cell and Tissue Research. 2003;313:93-105
Fernandez I, Zeiser R, Karsunky H, Kambham N, Beilhack A, Soderstrom K, Negrin RS, Engleman E. Cd101 surface
expression discriminates potency among murine foxp3+ regulatory t cells. J Immunol. 2007;179:2808-2814
Figg W, Li H, Sissung T, Retter A, Wu S, Gulley J, Arlen P, Wright J, Parnes H, Fedenko K. Pre clinical and clinical
evaluation of estramustine, docetaxel and thalidomide combination in androgen independent prostate cancer.
BJU International. 2007;99:1047-1055
Filonov GS, Piatkevich KD, Ting LM, Zhang J, Kim K, Verkhusha VV. Bright and stable near-infrared fluorescent
protein for in vivo imaging. Nature biotechnology. 2011
Fishbein I, Alferiev I, Bakay M, Stachelek SJ, Sobolewski P, Lai M, Choi H, Chen IW, Levy RJ. Local delivery of
gene vectors from bare-metal stents by use of a biodegradable synthetic complex inhibits in-stent restenosis in
rat carotid arteries. Circulation. 2008;117:2096-2103
Fisher K, Green N, Hale A, Subr V, Ulbrich K, Seymour L. Passive tumour targeting of polymer-coated adenovirus
for cancer gene therapy. Journal of Drug Targeting. 2007;15:546-551
Flanagan JM, Truksa J, Peng H, Lee P, Beutler E. In vivo imaging of hepcidin promoter stimulation by iron and
inflammation. Blood Cells, Molecules, and Diseases. 2007;38:253-257
661.
662.
663.
664.
665.
666.
667.
668.
669.
670.
671.
672.
673.
674.
675.
676.
677.
678.
679.
680.
681.
682.
683.
Flentie KN, Qi M, Gammon ST, Razia Y, Lui F, Marpegan L, Manglik A, Piwnica-Worms D, McKinney JS. Stably
integrated luxcdabe for assessment of salmonella invasion kinetics. Mol Imaging. 2008;7:222-233
Fleshker S, Preise D, Kalchenko V, Scherz A, Salomon Y. Prompt assessment of wst11-vtp outcome using
luciferase transfected tumors enables second treatment and increase in overall therapeutic rate. Photochem
Photobiol. 2008
Flores LG, Bertolini S, Yeh HH, Young D, Mukhopadhyay U, Pal A, Ying Y, Volgin A, Shavrin A, Soghomonyan S,
Tong W, Bornmann W, Alauddin MM, Logsdon C, Gelovani JG. Detection of pancreatic carcinomas by imaging
lactose-binding protein expression in peritumoral pancreas using [18f]fluoroethyl-deoxylactose pet/ct. PLoS
One. 2009;4
Fogal V, Richardson AD, Karmali PP, Scheffler IE, Smith JW, Ruoslahti E. Mitochondrial p32 protein is a critical
regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol.
2010;30:1303-1318
Fogar P, Navaglia F, Basso D, Zambon CF, Moserle L, Indraccolo S, Stranges A, Greco E, Fadi E, Padoan A, Pantano
G, Sanzari MC, Pedrazzoli S, Montecucco C, Plebani M. Heat-induced transcription of diphtheria toxin a or its
variants, crm176 and crm197: Implications for pancreatic cancer gene therapy. Cancer Gene Ther. 2009
Fomchenko EI, Holland EC. Mouse models of brain tumors and their applications in preclinical trials. Clin
Cancer Res. 2006;12:5288-5297
Fomicheva EV, Turner, II, Edwards TG, Hoff J, Arden E, D'Alecy LG, Metzger JM. Double oxygen-sensing vector
system for robust hypoxia/ischemia-regulated gene induction in cardiac muscle in vitro and in vivo. Mol Ther.
2008
Foster AE, Dotti G, Lu A, Khalil M, Brenner MK, Heslop HE, Rooney CM, Bollard CM. Antitumor activity of ebvspecific t lymphocytes transduced with a dominant negative tgf-β receptor. Journal of Immunotherapy.
2008;31:500-505
Foucault ML, Thomas L, Goussard S, Branchini BR, Grillot-Courvalin C. In vivo bioluminescence imaging for
the study of intestinal colonization by escherichia coli in mice. Appl Environ Microbiol. 2010;76:264-274
Fowler M, Virostko J, Chen Z, Poffenberger G, Radhika A, Brissova M, Shiota M, Nicholson WE, Shi Y, Hirshberg
B, Harlan DM, Jansen ED, Powers AC. Assessment of pancreatic islet mass after islet transplantation using in vivo
bioluminescence imaging. Transplantation. 2005;79:768-776
Fowler T, Wann ER, Joh D, Johansson S, Foster TJ, Hook M. Cellular invasion by staphylococcus aureus involves
a fibronectin bridge between the bacterial fibronectic-binding mscramms and host cell (beta)1 integrins.
European Journal of Cell Biology. 2000;79:672-679
Fox A, Kaur S, Li B, Panesar M, Saha U, Davis C, Dragoni I, Colley S, Ritchie T, Bevan S, Burgess G, McIntyre P.
Antihyperalgesic activity of a novel nonpeptide bradykinin b1 receptor antagonist in transgenic mice
expressing the human b1 receptor. British Journal of Pharmacology. 2005;144:889-899
Franc BL, Mandl SJ, Siprashvili Z, Wender P, Contag CH. Breaching biological barriers: Protein translocation
domains as tools for molecular imaging and therapy. Molecular Imaging. 2003;2:313-323
Francia G, Man S, Lee CJ, Lee CR, Xu P, Mossoba ME, Emmenegger U, Medin JA, Kerbel RS. Comparative impact
of trastuzumab and cyclophosphamide on her-2-positive human breast cancer xenografts. Clin Cancer Res.
2009;15:6358-6366
FRANCIS K, ZHANG W, CONTAG C, CONTAG P. The potential of molecular biophotonics in drug discovery.
High throughput screening: The next generation. Bios Scientific Publishers Ltd; 2000:53.
Francis KP, Joh D, Bellinger-Kawahara C, Hawkinson MJ, Purchio TF, Contag PR. Monitoring bioluminescent
staphylococcus aureus infections in living mice using a novel luxabcde construct. Infection and Immunity.
2000;68:3594-3600
Francis KP, Yu J, Bellinger-Kawahara C, Joh D, Hawkinson MJ, Xiao G, Purchio TF, Caparon MG, Lipsitch M,
Contag PR. Visualizing pneumococcal infections in the lungs of live mice using bioluminescent streptococcus
p n eu mo n i ae t ran s fo rmed wi t h a n o v el g ram-p o s i t i v e l u x t ran s p o s o n . In f ect i o n a n d Immu n i t y.
2001;69:3350-3358
Francis KP, Yu J, Bellinger-Kawahara C, Joh D, Purchio TF, Contag PR. Generation of bioluminescent grampositive bacteria for noninvasive imaging in living animals. Abstracts of the General Meeting of the American
Society for Microbiology. 2001;101:290
Frank SJ, Wang X, He K, Yang N, Fang P, Rosenfeld RG, Hwa V, Chaudhuri TR, Deng L, Zinn KR. In vivo imaging
of hepatic growth hormone signaling. Mol Endocrinol. 2006;20:2819-2830
Franke-Fayard B, Janse CJ, Cunha-Rodrigues M, Ramesar J, Büscher P, Que I, Löwik C, Voshol PJ, den Boer
MAM, van Duinen SG, Febbraio M, Mota MM, Waters AP. Murine malaria parasite sequestration: Cd36 is the
major receptor, but cerebral pathology is unlinked to sequestration. Proceedings of the National Academy of
Sciences of the United States of America. 2005;102:11468-11473
Franke-Fayard B, Waters AP, Janse CJ. Real-time in vivo imaging of transgenic bioluminescent blood stages of
rodent malaria parasites in mice. Nat Protoc. 2006;1:476-485
Froelich S, Ziegler L, Stroup K, Wang P. Targeted gene delivery to cd117-expressing cells in vivo with lentiviral
vectors co-displaying stem cell factor and a fusogenic molecule. Biotechnology and Bioengineering.
2009;104:206-215
Fu Q, Jia S, Sun Z, Tian F, Du J, Zhou Y, Wang Y, Wang X, Zhan L. C31 integrase and liver-specific regulatory
elements confer high-level, long-term expression of firefly luciferase in mouse liver. Biotechnology letters.
684.
685.
686.
687.
688.
689.
690.
691.
692.
693.
694.
695.
696.
697.
698.
699.
700.
701.
702.
703.
704.
705.
706.
707.
708.
2009;31:1151-1157
Fuhrmann G, Leroux J-C. In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal
tract. Proceedings of the National Academy of Sciences. 2011;108:9032-9037
Fujiki Y, Tao K, Bianchi DW, Giel-Moloney M, Leiter AB, Johnson KL. Quantification of green fluorescence
protein by in vivo imaging, pcr and flow cytometry: Comparison of transgenic strains and relevance for fetal cell
microchimerism. Cytometry A. 2008;73:11-118
Fujisaki H, Kakuda H, Shimasaki N, Imai C, Ma J, Lockey T, Eldridge P, Leung WH, Campana D. Expansion of
highly cytotoxic human natural killer cells for cancer cell therapy. Cancer Res. 2009;69:4010-4017
Fujishiro J, Kawana H, Inoue S, Shimizu H, Yoshino H, Hakamata Y, Kaneko T, Murakami T, Hashizume K,
Kobayashi E. Efficiency of adenovirus-mediated gene transduction in heart grafts in rats. Transplant Proc.
2005;37:67-69
Fujishiro J, Takeda S, Takeno Y, Takeuchi K, Ogata Y, Takahashi M, Hakamata Y, Kaneko T, Murakami T, Okada T.
Gene transfer to the rat kidney in vivo and ex vivo using an adenovirus vector: Factors influencing transgene
expression. Nephrology Dialysis Transplantation. 2005;20:1385
Fujita A, Migita M, Ueda T, Ogawa R, Fukunaga Y, Shimada T. Hematopoiesis in regenerated bone marrow within
hydroxyapatite scaffold. Pediatr Res. 2010;68:35-40
Fujita M, Khazenzon N, Lee B, Holler E, Black K, Ljubimova J. A multi-drug delivery system based on poly (malic
acid) for tumor targeting. Proceedings of the American Association for Cancer Research. 2006;2006:720
Fujita M, Lee BS, Khazenzon NM, Penichet ML, Wawrowsky KA, Patil R, Ding H, Holler E, Black KL, Ljubimova
JY. Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(β-l-malic
acid). J Control Release. 2007;122:356-363
Fukukawa C, Hanaoka H, Nagayama S, Tsunoda T, Toguchida J, Endo K, Nakamura Y, Katagiri T.
Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against fzd10. Cancer Sci.
2008;99:432-440
Fushiki H, Hayakawa Y, Gomori A, Seo T, Tewari S, Ozaki S, Yoshimoto R. In vivo imaging of obesity-induced
inflammation in adipose tissue. Biochemical and Biophysical Research Communications. 2010;391:674-678
Fushiki H, Kanoh-Azuma T, Katoh M, Kawabata K, Jiang J, Tsuchiya N, Satow A, Tamai Y, Hayakawa Y.
Quantification of mouse pulmonary cancer models by microcomputed tomography imaging. Cancer Sci.
2009;100:1544-1549
Gabriel D, Busso N, So A, van den Bergh H, Gurny R, Lange N. Thrombin-sensitive photodynamic agents: A novel
strategy for selective synovectomy in rheumatoid arthritis. J Control Release. 2009;138:225-234
Gad F, Zahra T, Francis KP, Hasan T, Hamblin MR. Targeted photodynamic therapy of established soft-tissue
infections in mice. Photochemical and Photobiological Sciences. 2004;3:451-458
Gade TPF, Hassen W, Santos E, Gunset G, Saudemont A, Gong MC, Brentjens R, Zhong X-S, Stephan M, Stefanski
J, Lyddane C, Osborne JR, Buchanan IM, Hall SJ, Heston WD, Riviere I, Larson SM, Koutcher JA, Sadelain M.
Targeted elimination of prostate cancer by genetically directed human t lymphocytes. Cancer Res.
2005;65:9080-9088
Gaffal E, Schweichel D, Tormo D, Steitz J, Lenz J, Basner-Tschakarjan E, Limmer A, Tüting T. Comparative
evaluation of cd8+ ctl responses following gene gun immunization targeting the skin with intracutaneous
injection of antigen-transduced dendritic cells. European Journal of Cell Biology. 2007;86:817-826
Gal-Mor O, Gibson DL, Baluta D, Vallance BA, Finlay BB. A novel secretion pathway of salmonella enterica acts
as an antivirulence modulator during salmonellosis. PLoS Pathog. 2008;4
Galkin AV, Melnick JS, Kim S, Hood TL, Li N, Li L, Xia G, Steensma R, Chopiuk G, Jiang J, Wan Y, Ding P, Liu Y,
Sun F, Schultz PG, Gray NS, Warmuth M. Identification of nvp-tae684, a potent, selective, and efficacious
inhibitor of npm-alk. Proceedings of the National Academy of Sciences of the United States of America.
2007;104:270-275
Gallaher SD, Gil JS, Dorigo O, Berk AJ. Robust in vivo transduction of a genetically stable epstein-barr virus
episome to hepatocytes in mice by a hybrid viral vector▿. J Virol. 2009;83:3249-3257
Gambhira R, Jagu S, Karanam B, Day PM, Roden R. Role of l2 cysteines in papillomavirus infection and
neutralization. Virol J. 2009;6:176
Gambhira R, Karanam B, Jagu S, Roberts JN, Buck CB, Bossis I, Alphs H, Culp T, Christensen ND, Roden RBS. A
protective and broadly cross-neutralizing epitope of human papillomavirus l2▿. J Virol. 2007;81:13927-13931
Gammon ST, Leevy WM, Gross S, Gokel GW, Piwnica-Worms D. Spectral unmixing of multicolored
bioluminescence emitted from heterogeneous biological sources. Analytical Chemistry. 2006;78:1520-1527
Gammon ST, Villalobos VM, Roshal M, Samrakandi M, Piwnica-Worms D. Rational design of novel red-shifted
bret pairs: Platforms for real-time single-chain protease biosensors. Biotechnol Prog. 2009;25:559-569
Ganapathy V, Ge R, Grazioli A, Xie W, Banach-Petrosky W, Kang Y, Lonning S, McPherson J, Yingling JM,
Biswas S, Mundy GR, Reiss M. Targeting the transforming growth factor-β pathway inhibits human basal-like
breast cancer metastasis. Mol Cancer. 2010;9:122
Ganesh S, Gonzalez Edick M, Idamakanti N, Abramova M, VanRoey M, Robinson M, Yun C, Jooss K. Relaxinexpressing, fiber chimeric oncolytic adenovirus prolongs survival of tumor-bearing mice. Cancer Res.
2007;67:4399
Ganesh S, Gonzalez-Edick M, Gibbons D, Van Roey M, Jooss K. Intratumoral coadministration of hyaluronidase
enzyme and oncolytic adenoviruses enhances virus potency in metastatic tumor models. Clin Cancer Res.
709.
710.
711.
712.
713.
714.
715.
716.
717.
718.
719.
720.
721.
722.
723.
724.
725.
726.
727.
728.
729.
730.
731.
2008;14:3933-3941
Gao J, Li Y, Lu S, Wang M, Yang Z, Yan X, Zheng Y. Enhanced in vivo motility of human umbilical cord blood
hematopoietic stem/progenitor cells introduced via intra-bone marrow injection into xenotransplanted nod/scid
mouse. Exp Hematol. 2009;37:990-997
Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, Bhujwalla ZM, Felsher DW, Cheng L, Pevsner J, Lee LA,
Semenza GL, Dang CV. Hif-dependent anti-tumorigenic effect of anti-oxidants in vivo. Cancer Cell.
2007;12:230-238
Gao Y, Ng SS, Chau DH, Yao H, Yang C, Man K, Huang PT, Huang C, Huang JJ, Kung HF, Lin MC. Development of
recombinant adeno-associated virus and adenovirus cocktail system for efficient htertc27 polypeptide-mediated
cancer gene therapy. Cancer Gene Ther. 2008;15:723-732
Gao YJ, Cheng JK, Zeng Q, Xu ZZ, Decosterd I, Xu X, Ji RR. Selective inhibition of jnk with a peptide inhibitor
attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. Experimental Neurology.
2009;219:146-155
Garbuzenko OB, Saad M, Betigeri S, Zhang M, Vetcher AA, Soldatenkov VA, Reimer DC, Pozharov VP, Minko T.
Intratracheal versus intravenous liposomal delivery of sirna, antisense oligonucleotides and anticancer drug.
Pharm Res. 2009;26:382-394
Garcez AS, Nunez SC, Lage-Marques JL, Hamblin MR, Ribeiro MS. Photonic real-time monitoring of bacterial
reduction in root canals by genetically engineered bacteria after chemomechanical endodontic therapy. Brazilian
Dental Journal. 2007;18:202-207
Garcia-Albeniz X, Nadal C, Gomis R. Murine models mimicking different colorectal cancer liver metastasis
phenotypes. Proceedings of the American Association for Cancer Research Annual Meeting. 2010;51:113
Gardner CL, Burke CW, Tesfay MZ, Glass PJ, Klimstra WB, Ryman KD. Eastern and venezuelan equine
encephalitis viruses differ in their ability to infect dendritic cells and macrophages: Impact of altered cell
tropism on pathogenesis▿. J Virol. 2008;82:10634-10646
Garrison SP, Thornton JA, Häcker H, Webby R, Rehg JE, Parganas E, Zambetti GP, Tuomanen EI. The p53-target
gene puma drives neutrophil-mediated protection against lethal bacterial sepsis. PLoS Pathogens. 2010
Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito
S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD,
Iolascon A, Zollo M. Microrna-199b-5p impairs cancer stem cells through negative regulation of hes1 in
medulloblastoma. PLoS ONE. 2009
Gaspar N, Li L, Kapoun A, Medicherla S, Reddy M, Li G, O'Young G, Quon D, Henson M, Damm D. Inhibition of
transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.
Molecular Pharmacology. 2007;72:152
Gasser J, Ingold P, Grosios K, Laib A, Hämmerle S, Koller B. Noninvasive monitoring of changes in structural
cancellous bone parameters with a novel prototype micro-ct. Journal of Bone and Mineral Metabolism.
2005;23:90-96
Gaur AB, Holbeck SL, Colburn NH, Israel MA. Downregulation of pdcd4 by mir-21 facilitates glioblastoma
proliferation in vivo. Neuro-oncology. 2011;13:580-590
Gaymalov ZZ, Yang Z, Pisarev VM, Alakhov VY, Kabanov AV. The effect of the nonionic block copolymer
pluronic p85 on gene expression in mouse muscle and antigen presenting cells. Biomaterials.
2009;30:1232-1245
Ge R, Wang Z, Zeng Q, Xu X, Olumi AF. F-box protein 10, an nf-kappab-dependent anti-apoptotic protein,
regulates trail-induced apoptosis through modulating c-fos/c-flip pathway. Cell death and differentiation.
2011;18:1184-1195
Geiben-Lynn R, Frimpong-Boateng K, Letvin NL. Modulation of plasmid DNA vaccine antigen clearance by
caspase 12 rna interference potentiates vaccination. Clinical and vaccine immunology : CVI. 2011;18:533-538
Geiben-Lynn R, Greenland J, Frimpong-Boateng K, Letvin N. Non-classical natural killer t cells modulate
plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by mcp-1 secretion after
interaction with a 2-microglobulin-independent cd1d. Journal of Biological Chemistry. 2009;284:33800
Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, Letvin NL. Kinetics of recombinant adenovirus type 5,
vaccinia virus, modified vaccinia ankara virus, and DNA antigen expression in vivo and the induction of memory
t-lymphocyte responses. Clin Vaccine Immunol. 2008;15:691-696
Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, van Rooijen N, Hovav AH, Letvin NL. Cd4+ t lymphocytes
mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate cd8+ t-cell immune
responses. Blood. 2008;112:4585-4590
Geiger J, Aneja MK, Hasenpusch G, Yuksekdag G, Kummerlowe G, Luy B, Romer T, Rothbauer U, Rudolph C.
Targeting of the prostacyclin specific ip1 receptor in lungs with molecular conjugates comprising prostaglandin
i2 analogues. Biomaterials. 2010;31:2903-2911
Gelderman MP, Chi X, Zhi L, Vostal JG. Ultraviolet b light-exposed human platelets mediate acute lung injury in
a two-event mouse model of transfusion. Transfusion. 2011
George AG, Yang G, Dennery PA. Binding of zinc proptophyrin to serum proteins and effect on apoptosis.
Pediatric Research. 2004;55:291A
George J, Banik NL, Ray SK. Molecular mechanisms of taxol for induction of cell death in glioblastomas. In: Ray
SK, ed. Glioblastoma. Springer New York; 2010:283-298.
732.
733.
734.
735.
736.
737.
738.
739.
740.
741.
742.
743.
744.
745.
746.
747.
748.
749.
750.
751.
752.
753.
754.
755.
756.
George J, Tsutsumi M. Sirna-mediated knockdown of connective tissue growth factor prevents nnitrosodimethylamine-induced hepatic fibrosis in rats. Gene Therapy. 2007;14:790-803
Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S, Hoebe K, Du X, Rutschmann S, Jiang Z,
Bigby T, Nizet V, Zouboulis CC, Beutler B. A toll-like receptor 2-responsive lipid effector pathway protects
mammals against skin infections with gram-positive bacteria. Infection and Immunity. 2005;73:4512-4521
Gerdoni E, Gallo B, Casazza S, Musio S, Bonanni I, Pedemonte E, Mantegazza R, Frassoni F, Mancardi G, Pedotti
R, Uccelli A. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental
autoimmune encephalomyelitis. Ann Neurol. 2007;61:219-227
Gestl SA, Leonard TL, Biddle JL, Debies MT, Gunther EJ. Dormant wnt-initiated mammary cancer can participate
in reconstituting functional mammary glands▿. Molecular and Cellular Biology. 2007;27:195-207
Geurts A, Wilber A, Carlson C, Lobitz P, Clark K, Hackett P, McIvor RS, Largaespada D. Conditional gene
expression in the mouse using a sleeping beauty gene-trap transposon. BMC Biotechnology. 2006;6:30
Ghali S, Bhatt K, Dempsey M, Jones D, Singh S, Arabi S, Butler P, Gallo R, Gurtner G. Treating chronic wound
infections with genetically modified free flaps. Plastic and Reconstructive Surgery. 2009;123:1157
Gheysens O, Chen IY, Rodriguez-Porcel M, Chan C, Rasooly J, Vaerenberg C, Paulmurugan R, Willmann JK,
Deroose C, Wu J, Gambhir SS. Non-invasive bioluminescence imaging of myoblast-mediated hypoxia-inducible
factor-1 alpha gene transfer. Molecular imaging and biology : MIB : the official publication of the Academy of
Molecular Imaging. 2011
Gheysens O, Shuan L, Feng C, Dongxu W, Ian YC, Martin R-P, Jung JM, Sanjiv SG, Joseph CW. Noninvasive
evaluation of immunosuppressive drug efficacy on acute donor cell survival. Molecular Imaging and Biology.
2006;V8:163-170
Ghods AJ, Irvin D, Liu G, Yuan X, Abdulkadir IR, Tunici P, Konda B, Wachsmann-Hogiu S, Black KL, Yu JS.
Spheres isolated from 9l gliosarcoma rat cell line possess chemoresistant and aggressive cancer stem-like cells.
Stem Cells. 2007;25:1645-1653
Ghoroghchian PP, Frail PR, Susumu K, Blessington D, Brannan AK, Bates FS, Chance B, Hammer DA, Therien MJ.
Near-infrared-emissive polymersomes: Self-assembled soft matter for in vivo optical imaging. Proceedings of
the National Academy of Sciences of the United States of America. 2005;102:2922-2927
Giannoni P, Scaglione S, Daga A, Ilengo C, Cilli M, Quarto R. Short-time survival and engraftment of bone
marrow stromal cells in an ectopic model of bone regeneration. Tissue Eng Part A. 2009
Giannoukakis N, Phillips B, Trucco M. Toward a cure for type 1 diabetes mellitus: Diabetes-suppressive dendritic
cells and beyond. Pediatr Diabetes. 2008;9:4-13
Gibson DL, Ma C, Bergstrom KS, Huang JT, Man C, Vallance BA. Myd88 signalling plays a critical role in host
defence by controlling pathogen burden and promoting epithelial cell homeostasis during citrobacter
rodentium-induced colitis. Cell Microbiol. 2008;10:618-631
Gibson DL, Ma C, Rosenberger CM, Bergstrom KS, Valdez Y, Huang JT, Khan MA, Vallance BA. Toll-like receptor
2 plays a critical role in maintaining mucosal integrity during citrobacter rodentium-induced colitis. Cell
Microbiol. 2008;10:388-403
Giering JC, Grimm D, Storm TA, Kay MA. Expression of shrna from a tissue-specific pol ii promoter is an
effective and safe rnai therapeutic. Mol Ther. 2008;16:1630-1636
Gilbert H, Cumming J, Prchal JT, Kinsey M, Shami P. Gst-n and nitric oxide: A novel approach to mantle cell
lymphoma therapy. Blood. 2009;114:1436
Gill E, Palmer G, Ramanujam N. Steady-state fluorescence imaging of neoplasia. Methods in Enzymology.
2002:452-480
Gill MB, Wright DE, Smith CM, May JS, Stevenson PG. Murid herpesvirus-4 lacking thymidine kinase reveals
route-dependent requirements for host colonization. J Gen Virol. 2009;90:1461-1470
Gillard GO, Bivas-Benita M, Hovav AH, Grandpre LE, Panas MW, Seaman MS, Haynes BF, Letvin NL. Thy1 nk
cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of
adaptive lymphocytes. PLoS pathogens. 2011;7:e1002141
Gillespie D, Whang K, Ragel B, Flynn J, Kelly D, Jensen R. Silencing of hypoxia inducible factor-1 by rna
interference attenuates human glioma cell growth in vivo. Clinical Cancer Research. 2007;13:2441
Gimi B, Kwon J, Liu L, Su Y, Nemani K, Trivedi K, Cui Y, Vachha B, Mason R, Hu W, Lee JB. Cell encapsulation
and oxygenation in nanoporous microcontainers. Biomed Microdevices. 2009;11:1205-1212
Giri RS, Thaker HM, Giordano T, Williams J, Rogers D, Vasu KK, Sudarsanam V. Design, synthesis and evaluation
of novel 2-thiophen-5-yl-3h-quinazolin-4-one analogues as inhibitors of transcription factors nf-small ka,
cyrillicb and ap-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anticancer agents. Bioorg Med Chem. 2010
Gitler M, Sausville E, Hollingshead M, Shoemaker R. In vivo models for experimental therapeutics relevant to
human cancer. Cancer Res. 2004;64:8478
Giubellino A, Gao Y, Lee S, Lee M, Vasselli J, Medepalli S, Trepel J, Burke T, Bottaro D. Inhibition of tumor
metastasis by a growth factor receptor bound protein 2 src homology 2 domain–binding antagonist. Cancer Res.
2007;67:6012
Giuriato S, Ryeom S, Fan AC, Bachireddy P, Lynch RC, Rioth MJ, van Riggelen J, Kopelman AM, Passegué E,
Tang F, Folkman J, Felsher DW. Sustained regression of tumors upon myc inactivation requires p53 or
thrombospondin-1 to reverse the angiogenic switch. Proceedings of the National Academy of Sciences of the
757.
758.
759.
760.
761.
762.
763.
764.
765.
766.
767.
768.
769.
770.
771.
772.
773.
774.
775.
776.
777.
778.
779.
780.
United States of America. 2006;103:16266-16271
Glomski IJ, Corre JP, Mock M, Goossens PL. Non-capsulated toxinogenic bacillus anthracis present a specific
growth and dissemination pattern in naive and pa-immune mice. Infect Immun. 2007
Glomski IJ, Dumetz F, Jouvion G, Huerre MR, Mock M, Goossens PL. Inhaled non-capsulated bacillus anthracis
in a/j mice: Nasopharynx and alveolar space as dual portals of entry, delayed dissemination, and specific organ
targeting. Microbes Infect. 2008;10:1398-1404
Glomski IJ, Piris-Gimenez A, Huerre M, Mock M, Goossens PL. Primary involvement of pharynx and peyer's
patch in inhalational and intestinal anthrax. PLoS Pathog. 2007;3
Glowalla E, Tosetti B, Krönke M, Krut O. Proteomics-based identification of anchorless cell wall proteins as
vaccine candidates against staphylococcus aureus▿†. Infection and Immunity. 2009;77:2719-2729
Goebel EM, Wolfe DN, Elder K, Stibitz S, Harvill ET. O antigen protects bordetella parapertussis from
complement. Infect Immun. 2008;76:1774-1780
Goldhoff P, Warrington N, Limbrick DD, Hope A, Woerner BM, Jackson E, Perry A, Piwnica-Worms D, Rubin JB.
Ccr-08-0827 version 2 targeted inhibition of cyclic amp phosphodiesterase-4 promotes brain tumor regression.
Clinical Cancer Research. 2008;14:7717-7725
Goldhoff P, Warrington NM, Limbrick DD, Jr., Hope A, Woerner BM, Jackson E, Perry A, Piwnica-Worms D, Rubin
JB. Targeted inhibition of cyclic amp phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res.
2008;14:7717-7725
Goldkorn A, Hann B, Hayes M, Drummond D, Kirpotin D, Peth K, Marks J, Blackburn E, Park J. Systemic
telomerase gene therapy delivered via targeted lipidic nanoparticles. Journal of Clinical Oncology.
2006;24:13025
Goldshaid L, Rubinstein E, Brandis A, Segal D, Leshem N, Brenner O, Kalchenko V, Eren D, Yecheskel T, Salitra Y,
Salomon Y, Scherz A. Novel design principles enable specific targeting of imaging and therapeutic agents to
necrotic domains in breast tumors. Breast Cancer Res. 2010;12:R29
Gomes CM, Welling M, Que I, Henriquez NV, van der Pluijm G, Romeo S, Abrunhosa AJ, Botelho MF,
Hogendoorn PC, Pauwels EK, Cleton-Jansen AM. Functional imaging of multidrug resistance in an orthotopic
model of osteosarcoma using (99m)tc-sestamibi. Eur J Nucl Med Mol Imaging. 2007
Gomez CE, Najera JL, Domingo-Gil E, Ochoa-Callejero L, Gonzalez-Aseguinolaza G, Esteban M. Virus
distribution of the attenuated mva and nyvac poxvirus strains in mice. J Gen Virol. 2007;88:2473-2478
Gomis RR, Alarcon C, Nadal C, Van Poznak C, Massague J. C/ebpbeta at the core of the tgfbeta cytostatic
response and its evasion in metastatic breast cancer cells. Cancer Cell. 2006;10:203-214
Goncharova E, Bulychev L, Poryvaev V, Ryzhikov A. Olfactory propagation of neurotropic viruses into the brain
and intranasal immunization against tick-borne encephalitis. Progress in encephalitis research. 2005:117
Gondi CS, Veeravalli KK, Gorantla B, Dinh DH, Fassett D, Klopfenstein JD, Gujrati M, Rao JS. Human umbilical
cord blood stem cells show pdgf-d-dependent glioma cell tropism in vitro and in vivo. Neuro Oncol.
2010;12:453-465
Gonzalez Carmona M, Lukacs Kornek V, Timmerman A, Shabani S, Kornek M, Vogt A, Yildiz Y, Sievers E,
Schmidt Wolf I, Caselmann W. Cd40ligand expressing dendritic cells induce regression of hepatocellular
carcinoma by activating innate and acquired immunity in vivo. Hepatology. 2008;48:157-168
Gonzalez-Aparicio M, Alzuguren P, Mauleon I, Medina-Echeverz J, Hervas-Stubbs S, Mancheno U, Berraondo P,
Crettaz J, Gonzalez-Aseguinolaza G, Prieto J, Hernandez-Alcoceba R. Oxaliplatin in combination with liverspecific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and
eradicates metastatic colorectal cancer in mice. Gut. 2011;60:341-349
Gonzalez-Gonzalez E, Ra H, Spitler R, Hickerson RP, Contag CH, Kaspar RL. Increased interstitial pressure
improves nucleic acid delivery to skin enabling a comparative analysis of constitutive promoters. Gene therapy.
2010;17:1270-1278
González-Zorn B, Senna JPM, Fiette L, Shorte S, Testard A, Chignard M, Courvalin P, Grillot-Courvalin C.
Bacterial and host factors implicated in nasal carriage of methicillin-resistant staphylococcus aureus in mice.
Infection and Immunity. 2005;73:1847-1851
Gopal AK, Press OW, Wilbur SM, Maloney DG, Pagel JM. Rituximab blocks binding of radiolabeled anti-cd20
antibodies (ab) but not radiolabeled anti-cd45 ab. Blood. 2008;112:830-835
Gorbatyuk M, Justilien V, Liu J, Hauswirth W, Lewin A. Preservation of photoreceptor morphology and function
in p23h rats using an allele independent ribozyme. Experimental Eye Research. 2007;84:44-52
Goudy KS, Wang B, Tisch R. Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a
late preclinical stage of type 1 diabetes in nonobese diabetic mice. Clinical Immunology. 2008;129:49-57
Gould D, Yousaf N, Fatah R, Subang MC, Chernajovsky Y. Gene therapy with an improved doxycycline-regulated
plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis. Arthritis Res Ther.
2007;9:R7
Goun EA, Shinde R, Dehnert KW, Adams-Bond A, Wender PA, Contag CH, Franc BL. Intracellular cargo delivery
by an octaarginine transporter adapted to target prostate cancer cells through cell surface protease activation.
Bioconjug Chem. 2006;17:787-796
Graham A, Stuart R, LaRue A, Rosol M. Tracking of leukemic stem cells from frozen and fresh samples in a mouse
model of human aml using bioluminescent imaging. Proceedings of the American Association for Cancer
Research Annual Meeting. 2010;51:1052
781.
782.
783.
784.
785.
786.
787.
788.
789.
790.
791.
792.
793.
794.
795.
796.
797.
798.
799.
800.
801.
802.
803.
804.
805.
806.
Granero-Molto F, Weis JA, Miga MI, Landis B, Myers TJ, O'Rear L, Longobardi L, Jansen ED, Mortlock DP,
Spagnoli A. Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells. 2009
Granot D, Addadi Y, Kalchenko V, Harmelin A, Kunz-Schughart LA, Neeman M. In vivo imaging of the systemic
recruitment of fibroblasts to the angiogenic rim of ovarian carcinoma tumors. Cancer Res. 2007;67:9180-9189
Gravel M, Weng YC, Kriz J. Model system for live imaging of neuronal responses to injury and repair. Molecular
imaging. 2011
Gray MJ, Van Buren G, Dallas NA, Xia L, Wang X, Yang AD, Somcio RJ, Lin YG, Lim S, Fan F, Mangala LS,
Arumugam T, Logsdon CD, Lopez-Berestein G, Sood AK, Ellis LM. Therapeutic targeting of neuropilin-2 on
colorectal carcinoma cells implanted in the murine liver. J Natl Cancer Inst. 2008;100:109-120
Greene IP, Lee EY, Prow N, Ngwang B, Griffin DE. Protection from fatal viral encephalomyelitis: Ampa receptor
antagonists have a direct effect on the inflammatory response to infection. Proceedings of the National Academy
of Sciences of the United States of America. 2008;105:3575-3580
Greenland JR, Geiben R, Ghosh S, Pastor WA, Letvin NL. Plasmid DNA vaccine-elicited cellular immune
responses limit in vivo vaccine antigen expression through fas-mediated apoptosis1. Journal of Immunology.
2007;178:5652-5658
Greig JA, Buckley SM, Waddington SN, Parker AL, Bhella D, Pink R, Rahim AA, Morita T, Nicklin SA, McVey JH,
Baker AH. Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (ad) 5, ad35, and
chimeric ad5/ad35 vectors. Mol Ther. 2009
Greish K, Araki K, Li D, O’Malley BW, Dandu R, Frandsen J, Cappello J, Ghandehari H. Silk-elastinlike protein
polymer hydrogels for localized adenoviral gene therapy of head and neck tumors. Biomacromolecules.
2009;10:2183
Greish K, Frandsen J, Scharff S, Gustafson J, Cappello J, Li D, O'Malley BW, Jr., Ghandehari H. Silk-elastinlike
protein polymers improve the efficacy of adenovirus thymidine kinase enzyme prodrug therapy of head and neck
tumors. J Gene Med. 2010;12:572-579
Greter M, Hofmann J, Becher B. Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated
immunity. PLoS Biol. 2009;7
Griesenbach U, Meng C, Farley R, Cheng SH, Scheule RK, Davies MH, Wolstenholme-Hogg PC, ten Hove W, van
der Hoeven P, Sinn PL, McCray PB, Jr., Inoue M, Geddes DM, Hasegawa M, Frankel G, Wiles S, Alton EW. In vivo
imaging of gene transfer to the respiratory tract. Biomaterials. 2008;29:1533-1540
Griesenbach U, Meng C, Farley R, Gardner A, Brake MA, Frankel GM, Gruenert DC, Cheng SH, Scheule RK, Alton
EW. The role of doxorubicin in non-viral gene transfer in the lung. Biomaterials. 2009;30:1971-1977
Griesenbach U, Vicente CC, Roberts MJ, Meng C, Soussi S, Xenariou S, Tennant P, Baker A, Baker E, Gordon C,
Vrettou C, McCormick D, Coles R, Green AM, Lawton AE, Sumner-Jones SG, Cheng SH, Scheule RK, Hyde SC, Gill
DR, Collie DD, McLachlan G, Alton EW. Secreted gaussia luciferase as a sensitive reporter gene for in vivo and ex
vivo studies of airway gene transfer. Biomaterials. 2011;32:2614-2624
Griffin AJ, Li LX, Voedisch S, Pabst O, McSorley SJ. Dissemination of persistent intestinal bacteria via the
mesenteric lymph nodes causes typhoid relapse. Infection and immunity. 2011;79:1479-1488
Griffin D, Byrnes A, Cook S. Emergence and virulence of encephalitogenic arbo viruses. Emergence and control
of zoonotic viral encephalitides. 2004;18:21-33
Grogan R, Chang E, Aarabi S, Ceradini D, Gurtner G. Deferoxamine corrects diabetic neovascularization defects by
reactive oxygen species blockade. Plastic and Reconstructive Surgery. 2006;118:68
Gross S, Abraham U, Prior JL, Herzog ED, Piwnica-Worms D. Continuous delivery of d-luciferin by implanted
micro-osmotic pumps enables true real-time bioluminescence imaging of luciferase activity in vivo. Mol
Imaging. 2007;6:121-130
Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D. Bioluminescence
imaging of myeloperoxidase activity in vivo. Nat Med. 2009;15:455-461
Gross S, Piwnica-Worms D. Spying on cancer: Molecular imaging in vivo with genetically encoded reporters.
Cancer Cell. 2005;7:5-15
Gross S, Piwnica-Worms D. Monitoring proteasome activity in cellulo and in living animals by bioluminescent
imaging: Technical considerations for design and use of genetically encoded reporters. Methods in Enzymology.
2005;399:512-530
Grossman EJ, Lee DD, Tao J, Wilson RA, Park SY, Bell GI, Chong AS. Glycemic control promotes pancreatic betacell regeneration in streptozotocin-induced diabetic mice. PLoS One. 2010;5:e8749
Grozio A, Paleari L, Catassi A, Servent D, Cilli M, Piccardi F, Paganuzzi M, Cesario A, Granone P, Mourier G,
Russo P. Natural agents targeting the (alpha)7-nicotinic-receptor in nsclc: A promising prospective in anticancer drug development. International Journal of Cancer. 2008;122:1911-1915
Gruber PJ, Li Z, Li H, Worrad D, Huang B, Abdullah I, Wang W, El-Deiry W, Ferrari VA, Zhou R. In vivo imaging of
mlc2v-luciferase, a cardiac-specific reporter gene expression in mice. Academic Radiology. 2004;11:1022-1028
Gu L, Tsark WM, Brown DA, Blanchard S, Synold TW, Kane SE. A new model for studying tissue-specific mdr1a
gene expression in vivo by live imaging. Proceedings of the National Academy of Sciences of the United States
of America. 2009;106:5394-5399
Guenther C, Pantalena-Filho L, Kingsley DM. Shaping skeletal growth by modular regulatory elements in the
bmp5 gene. PLoS Genet. 2008;4
Gueven N, Fukao T, Luff J, Paterson C, Kay G, Kondo N, Lavin MF. Regulation of the atm promoter in vivo. Genes,
807.
808.
809.
810.
811.
812.
813.
814.
815.
816.
817.
818.
819.
820.
821.
822.
823.
824.
825.
826.
827.
828.
829.
Chromosomes and Cancer. 2006;45:61-71
Guha S, Verma A, Mehta K. Tissue transglutamimase downregulation potentiates gemcitabine efficacy and blocks
pancreatic cancer growth in vivo. Gastroenterology. 2008;134:A149
Guillot P, Abass O, Bassett J, Shefelbine S, Bou-Gharios G, Chan J, Kurata H, Williams G, Polak J, Fisk N.
Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and
reduces fractures in osteogenesis imperfecta mice. Blood. 2008;111:1717
Guillot P, Cook H, Pusey C, Fisk N, Harten S, Moss J, Shore I, Bou-Gharios G. Transplantation of human fetal
mesenchymal stem cells improves glomerulopathy in a collagen type ialpha2-deficient mouse. J Pathol.
2008;214:627-636
Gule MK, Chen Y, Sano D, Frederick MJ, Zhou G, Zhao M, Milas ZL, Galer CE, Henderson YC, Jasser SA, Schwartz
DL, Bankson JA, Myers JN, Lai SY. Targeted therapy of vegfr2 and egfr significantly inhibits growth of
anaplastic thyroid cancer in an orthotopic murine model. Clinical cancer research : an official journal of the
American Association for Cancer Research. 2011;17:2281-2291
Gumireddy K, Li A, Gimotty PA, Klein-Szanto AJ, Showe LC, Katsaros D, Coukos G, Zhang L, Huang Q. Klf17 is a
negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat Cell Biol.
2009;11:1297-1304
Gumireddy K, Sun F, Klein-Szanto AJ, Gibbins JM, Gimotty PA, Saunders AJ, Schultz PG, Huang Q. In vivo
selection for metastasis promoting genes in the mouse. Proceedings of the National Academy of Sciences of the
United States of America. 2007;104:6696-6701
Guo DY, Ng KTP, Cheng Q, Lim ZXH, Lam TT, Man K. A garlic derivative s-allylcysteine suppresses liver tumor
growth and metastasis by sensitizing chemotherapy. Hepatology International. 2009;3:138
Guo JT, Yu J, Grass D, De Beer FC, Kindy MS. Inflammation-dependent cerebral deposition of serum amyloid a
protein in a mouse model of amyloidosis. Journal of Neuroscience. 2002;22:5900-5909
Guo XF, Zhu XF, Shang Y, Zhang SH, Zhen YS. A bispecific enediyne-energized fusion protein containing ligandbased and antibody-based oligopeptides against epidermal growth factor receptor and human epidermal growth
factor receptor 2 shows potent antitumor activity. Clin Cancer Res. 2010;16:2085-2094
Guse K, Dias JD, Bauerschmitz GJ, Hakkarainen T, Aavik E, Ranki T, Pisto T, Sarkioja M, Desmond RA, Kanerva A,
Hemminki A. Luciferase imaging for evaluation of oncolytic adenovirus replication in vivo. Gene Ther.
2007;14:902-911
Guse K, Ranki T, Ala-Opas M, Bono P, Sarkioja M, Rajecki M, Kanerva A, Hakkarainen T, Hemminki A. Treatment
of metastatic renal cancer with capsid-modified oncolytic adenoviruses. Mol Cancer Ther. 2007;6:2728-2736
Guse K, Sloniecka M, Diaconu I, Ottolino-Perry K, Tang N, Ng C, Le Boeuf F, Bell JC, McCart JA, Ristimaki A,
Pesonen S, Cerullo V, Hemminki A. Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor
efficacy in renal cell cancer models. J Virol. 2010;84:856-866
Gutmann D, Baker S, Giovannini M, Garbow J, Weiss W. Mouse models of human cancer consortium symposium
on nervous system tumors. Cancer Res. 2003;63:3001
Guy R, Bensimon R, Greco R, Pozner J, Saltz R, Kaweski S, Yates D. Panel discussion-special closing session:
Skin care for life: Part of a comprehensive plastic surgery practice. Plastic and Reconstructive Surgery.
2006;118:72
Haase R, Argyros O, Wong SP, Harbottle RP, Lipps HJ, Ogris M, Magnusson T, Pinto MGV, Haas J, Baiker A.
Pepito: A significantly improved non-viral episomal expression vector for mammalian cells. BMC Biotechnol.
2010;10:20
Hadaschik B, Zhang K, So A, Fazli L, Jia W, Bell J, Gleave M, Rennie P. Oncolytic vesicular stomatitis viruses are
potent agents for intravesical treatment of high-risk bladder cancer. Cancer Res. 2008;68:4506
Hadaschik BA, Adomat H, Fazli L, Fradet Y, Andersen RJ, Gleave ME, So AI. Intravesical chemotherapy of highgrade bladder cancer with hti-286, a synthetic analogue of the marine sponge product hemiasterlin. Clin Cancer
Res. 2008;14:1510-1518
Hadaschik BA, Black PC, Sea JC, Metwalli AR, Fazli L, Dinney CP, Gleave ME, So AI. A validated mouse model
for orthotopic bladder cancer using transurethral tumour inoculation and bioluminescence imaging. BJU Int.
2007
Hadaschik BA, Jackson J, Fazli L, Zoubeidi A, Burt HM, Gleave ME, So AI. Intravesically administered antisense
oligonucleotides targeting heat-shock protein-27 inhibit the growth of non-muscle-invasive bladder cancer. BJU
Int. 2008;102:610-616
Hadaschik BA, ter Borg MG, Jackson J, Sowery RD, So AI, Burt HM, Gleave ME. Paclitaxel and cisplatin as
intravesical agents against non-muscle-invasive bladder cancer. BJU Int. 2008;101:1347-1355
Haga K, Tomioka A, Liao CP, Kimura T, Matsumoto H, Ohno I, Hermann K, Logg CR, Jiao J, Tanaka M, Hirao Y,
Wu H, Kruse CA, Roy-Burman P, Kasahara N. Pten knockout prostate cancer as a model for experimental
immunotherapy. Journal of Urology. 2009;181:354-362
Hajdena-Dawson M, Zhang W, Contag PR, Wong RJ, Vreman HJ, Stevenson DK, Contag CH. Effects of
metalloporphyrins on heme oxygenase-1 transcription: Correlative cell culture assays guide in vivo imaging.
Molecular Imaging. 2003;2:138-149
Hajitou A, Lev DC, Hannay JAF, Korchin B, Staquicini FI, Soghomonyan S, Alauddin MM, Benjamin RS, Pollock
RE, Gelovani JG, Pasqualini R, Arap W. A preclinical model for predicting drug response in soft-tissue sarcoma
with targeted aavp molecular imaging. Proceedings of the National Academy of Sciences of the United States of
830.
831.
832.
833.
834.
835.
836.
837.
838.
839.
840.
841.
842.
843.
844.
845.
846.
847.
848.
849.
850.
851.
852.
853.
854.
America. 2008;105:4471-4476
Hakamata Y, Murakami T, Kobayashi E. "Firefly rats" as an organ/cellular source for long-term in vivo
bioluminescent imaging. [article]. Transplantation. 2006
Hakkarainen T, Särkioja M, Lehenkari P, Miettinen S, Ylikomi T, Suuronen R, Desmond R, Kanerva A, Hemminki
A. Human mesenchymal stem cells lack tumor tropism but enhance the antitumor activity of oncolytic
adenoviruses in orthotopic lung and breast tumors. Human Gene Therapy. 2007;18:627-641
Halder J, Lin YG, Merritt WM, Spannuth WA, Nick AM, Honda T, Kamat AA, Han LY, Kim TJ, Lu C, Tari AM,
Bornmann W, Fernandez A, Lopez-Berestein G, Sood AK. Therapeutic efficacy of a novel focal adhesion kinase
inhibitor tae226 in ovarian carcinoma. Cancer Res. 2007;67:10976-10983
Haley ES, Au GG, Carlton BR, Barry RD, Shafren DR. Regional administration of oncolytic echovirus 1 as a novel
therapy for the peritoneal dissemination of gastric cancer. J Mol Med. 2009;87:385-399
Hall C, Zhang H, Baile S, Ljungman M, Kuhstoss S, Keller E. P21cip-1/waf-1 induction is required to inhibit
prostate cancer growth elicited by deficient expression of the wnt inhibitor dickkopf-1. Cancer Res.
2010;70:9916
Halldén G, Thorne SH, Yang J, Kirn DH. Replication-selective oncolytic adenoviruses. Suicide gene therapy.
2003:71-90.
Halpern J, Lynch C, Fleming J, Hamming D, Martin M, Schwartz H, Matrisian L, Holt G. The application of a
murine bone bioreactor as a model of tumor: Bone interaction. Clinical and Experimental Metastasis.
2006;23:345-356
Hambardzumyan D, Amankulor NM, Helmy KY, Becher OJ, Holland EC. Modeling adult gliomas using rcas/t-va
technology. Transl Oncol. 2009;2:89-95
Hamed HA, Yacoub A, Park MA, Eulitt PJ, Dash R, Sarkar D, Dmitriev IP, Lesniak MS, Shah K, Grant S, Curiel DT,
Fisher PB, Dent P. Inhibition of multiple protective signaling pathways and ad.5/3 delivery enhances mda-7/
il-24 therapy of malignant glioma. Mol Ther. 2010
Hamm CA, Xie H, Costa FF, Vanin EF, Seftor EA, Sredni ST, Bischof J, Wang D, Bonaldo MF, Hendrix MJ, Soares
MB. Global demethylation of rat chondrosarcoma cells after treatment with 5-aza-2'-deoxycytidine results in
increased tumorigenicity. PLoS One. 2009;4:e8340
Hamner JB, Dickson PV, Sims TL, Zhou J, Spence Y, Ng CY, Davidoff AM. Bortezomib inhibits angiogenesis and
reduces tumor burden in a murine model of neuroblastoma. Surgery. 2007;142:185-191
Hamstra DA, Bhojani MS, Griffin LB, Laxman B, Ross BD, Rehemtulla A. Real-time evaluation of p53 oscillatory
behavior in vivo using bioluminescent imaging. Cancer Res. 2006;66:7482-7489
Han Z, Fu A, Wang H, Diaz R, Geng L, Onishko H, Hallahan DE. Noninvasive assessment of cancer response to
therapy. Nat Med. 2008;14:343-349
Hangalapura BN, Oosterhoff D, de Groot J, Boon L, Tuting T, van den Eertwegh AJ, Gerritsen WR, van Beusechem
VW, Pereboev A, Curiel DT, Scheper RJ, de Gruijl TD. Potent anti-tumor immunity generated by a cd40-targeted
adenoviral vaccine. Cancer Res. 2011
Hao J, Simard AR, Turner GH, Wu J, Whiteaker P, Lukas RJ, Shi FD. Attenuation of cns inflammatory responses by
nicotine involves alpha7 and non-alpha7 nicotinic receptors. Experimental neurology. 2011;227:110-119
Hao Y, Xie T, Korotcov A, Zhou Y, Pang X, Shan L, Ji H, Sridhar R, Wang P, Califano J, Gu X. Salvianolic acid b
inhibits growth of head and neck squamous cell carcinoma in vitro and in vivo via cyclooxygenase-2 and
apoptotic pathways. International Journal of Cancer. 2009;124:2200-2209
Haque A, Best SE, Amante FH, Ammerdorffer A, de Labastida F, Pereira T, Ramm GA, Engwerda CR. High parasite
burdens cause liver damage in mice following plasmodium berghei anka infection independently of cd8(+) t cellmediated immune pathology. Infection and immunity. 2011;79:1882-1888
Haque A, Best SE, Amante FH, Mustafah S, Desbarrieres L, de Labastida F, Sparwasser T, Hill GR, Engwerda CR.
Cd4+ natural regulatory t cells prevent experimental cerebral malaria via ctla-4 when expanded in vivo. PLoS
Pathogens. 2010
Haque A, Best SE, Unosson K, Amante FH, de Labastida F, Anstey NM, Karupiah G, Smyth MJ, Heath WR,
Engwerda CR. Granzyme b expression by cd8+ t cells is required for the development of experimental cerebral
malaria. Journal of immunology. 2011;186:6148-6156
Hara M, Murakami T, Kobayashi E. In vivo bioimaging using photogenic rats: Fate of injected bone marrowderived mesenchymal stromal cells. J Autoimmun. 2008;30:163-171
Harada H, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M. The akt/mtor pathway
assures the synthesis of hif-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated
tumors. J Biol Chem. 2009;284:5332-5342
Harada H, Itasaka S, Zhu Y, Zeng L, Xie X, Morinibu A, Shinomiya K, Hiraoka M. Treatment regimen determines
whether an hif-1 inhibitor enhances or inhibits the effect of radiation therapy. British Journal of Cancer.
2009;100:747-757
Harada H, Kizaka-Kondoh S, Hiraoka M. Optical imaging of tumor hypoxia and evaluation of efficacy of a
hypoxia-targeting drug in living animals. Molecular Imaging. 2005;4:182-193
Harada H, Kizaka-Kondoh S, Li G, Itasaka S, Shibuya K, Inoue M, Hiraoka M. Significance of hif-1-active cells in
angiogenesis and radioresistance. Oncogene. 2007
Hardy J, Chu P, Contag CH. Foci of listeria monocytogenes persist in the bone marrow. Dis Model Mech.
2009;2:39-46
855.
856.
857.
858.
859.
860.
861.
862.
863.
864.
865.
866.
867.
868.
869.
870.
871.
872.
873.
874.
875.
876.
877.
878.
879.
880.
881.
882.
883.
Hardy J, Edinger M, Bachmann MH, Negrin RS, Fathman CG, Contag CH. Bioluminescence imaging of
lymphocyte trafficking in vivo. Exp Hematol. 2001;29:1353-1360
Hardy J, Francis KP, DeBoer M, Chu P, Gibbs K, Contag CH. Extracellular replication of listeria monocytogenes
in the murine gall bladder. Science. 2004;303:851-853
Hardy J, Margolis JJ, Contag CH. Induced biliary excretion of listeria monocytogenes. Infection and Immunity.
2006;74:1819-1827
Hariri G, Fu A, Han Z, Hallahan D. Radiation-inducible neoantigens for antibody targeted drug delivery.
International Journal of Radiation Oncology Biology Physics. 2005;63:S169
Hariri G, Wellons MS, Morris WH, 3rd, Lukehart CM, Hallahan DE. Multifunctional fept nanoparticles for
radiation-guided targeting and imaging of cancer. Annals of biomedical engineering. 2011;39:946-952
Hariri G, Yan H, Wang H. Nanoparticle albumin bound paclitaxel retargeted to radiation inducible tip-1 in cancer.
Clinical Cancer Research. 2010
Hariri G, Yan H, Wang H, Han Z, Hallahan D. Radiation-guided drug delivery to mouse models of lung cancer.
Clinical Cancer Research. 2010
Hariri G, Zhang Y, Fu A, Han Z, Brechbiel M, Tantawy MN, Peterson TE, Mernaugh R, Hallahan D. Radiationguided p-selectin antibody targeted to lung cancer. Annals of Biomedical Engineering. 2008;36:821-830
Harmache A, LeBerre M, Droineau S, Giovannini M, Brémont M. Bioluminescence imaging of live infected
salmonids reveals that the fin bases are the major portal of entry for novirhabdovirus. J Virol.
2006;80:3655-3659
Harrell MI, Iritani BM, Ruddell A. Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph
flow precede melanoma metastasis. American Journal of Pathology. 2007;170:774-786
Harris TJ, Green JJ, Fung PW, Langer R, Anderson DG, Bhatia SN. Tissue-specific gene delivery via nanoparticle
coating. Biomaterials. 2010;31:998-1006
Hart KM, Bak SP, Alonso A, Berwin B. Phenotypic and functional delineation of murine cx3cr1+ monocytederived cells in ovarian cancer12. Neoplasia. 2009;11:564-573
Hart LS, El-Deiry WS. Invincible, but not invisible: Imaging approaches toward in vivo detection of cancer stem
cells. J Clin Oncol. 2008;26:2901-2910
Hartel T, Klein M, Koedel U, Rohde M, Petruschka L, Hammerschmidt S. Impact of glutamine transporters on
pneumococcal fitness under infection-related conditions. Infection and immunity. 2011;79:44-58
Hartojo W, Silvers AL, Thomas DG, Seder CW, Lin L, Rao H, Wang Z, Greenson JK, Giordano TJ, Orringer MB,
Rehemtulla A, Bhojani MS, Beer DG, Chang AC. Curcumin promotes apoptosis, increases chemosensitivity, and
inhibits nuclear factor kappab in esophageal adenocarcinoma. Transl Oncol. 2010;3:99-108
Hasegawa K, Nakamura T, Harvey M, Ikeda Y, Oberg A, Figini M, Canevari S, Hartmann L, Peng K. The use of a
tropism-modified measles virus in folate receptor–targeted virotherapy of ovarian cancer. Clinical Cancer
Research. 2006;12:6170
Hasegawa K, Pham L, O'Connor M, Federspiel M, Russell S, Peng K. Dual therapy of ovarian cancer using measles
viruses expressing carcinoembryonic antigen and sodium iodide symporter. Clinical Cancer Research.
2006;12:1868
Hasenpusch G, Pfeifer C, Aneja MK, Wagner K, Reinhardt D, Gilon M, Ohana P, Hochberg A, Rudolph C.
Aerosolized bc-819 inhibits primary but not secondary lung cancer growth. PloS one. 2011;6:e20760
Hashizume R, Gupta N, Berger MS, Banerjee A, Prados MD, Ayers-Ringler J, James CD, VandenBerg SR.
Morphologic and molecular characterization of atrt xenografts adapted for orthotopic therapeutic testing. Neuro
Oncol. 2010;12:366-376
Hashizume R, Ozawa T, Dinca EB, Banerjee A, Prados MD, James CD, Gupta N. A human brainstem glioma
xenograft model enabled for bioluminescence imaging. J Neurooncol. 2009
Hassan M, Klaunberg B. Biomedical applications of fluorescence imaging in vivo. Comparative medicine.
2004;54:635-644
Hassibi A, Lee TH, Davis RW, Pourmand N. Bioluminescence regenerative cycle (brc) system for nucleic acid
quantification assays. Biophysical Chemistry. 2005;116:175-185
Hata N, Shinojima N, Gumin J, Yong R, Marini F, Andreeff M, Lang FF. Platelet-derived growth factor bb mediates
the tropism of human mesenchymal stem cells for malignant gliomas. Neurosurgery. 2010;66:144-156;
discussion 156-147
Hata T, Iwasaki J, Hishikawa S, Fujimoto Y, Uemoto S, Kobayashi E. Development of a portocaval shunt using a
small intestinal segment in rats. Microsurgery. 2010;30:302-306
Hatton BA, Villavicencio EH, Tsuchiya KD, Pritchard JI, Ditzler S, Pullar B, Hansen S, Knoblaugh SE, Lee D,
Eberhart CG, Hallahan AR, Olson JM. The smo/smo model: Hedgehog-induced medulloblastoma with 90%
incidence and leptomeningeal spread. Cancer Res. 2008;68:1768-1776
Hauck E, Zou S, Nantz M, Hecker J. In-vivo time course of reporter gene expression after nucleic acid delivery to
the lateral ventricle in rat brain. Molecular Therapy. 2005;11:S224
Hauck ES, Zou S, Scarfo K, Nantz MH, Hecker JG. Whole animal in vivo imaging after transient, nonviral gene
delivery to the rat central nervous system. Mol Ther. 2008;16:1857-1864
Haugen F, Drevon C. Activation of nuclear factor-{kappa} b by high molecular weight and globular adiponectin.
Endocrinology. 2007;148:5478
Hauschild G, Bader A. Advantages and disadvantages of synthetic versus xenogen bone-grafts. Tierarztliche
884.
885.
886.
887.
888.
889.
890.
891.
892.
893.
894.
895.
896.
897.
898.
899.
900.
901.
902.
903.
904.
905.
906.
Praxis Ausgabe Kleintiere Heimtiere. 2004;32:67-+
Havens AM, Pedersen EA, Shiozawa Y, Ying C, Jung Y, Sun Y, Neeley C, Wang J, Mehra R, Keller ET, McCauley
LK, Loberg RD, Pienta KJ, Taichman RS. An in vivo mouse model for human prostate cancer metastasis.
Neoplasia. 2008;10:371-380
Hawes JJ, Reilly KM. Bioluminescent approaches for measuring tumor growth in a mouse model of
neurofibromatosis. Toxicol Pathol. 2010;38:123-130
Hayward MD, Jones BK, Saparov A, Hain HS, Trillat AC, Bunzel MM, Corona A, Li-Wang B, Strenkowski B,
Giordano C, Shen H, Arcamone E, Weidlick J, Vilensky M, Tugusheva M, Felkner RH, Campbell W, Rao Y, Grass
DS, Buiakova O. An extensive phenotypic characterization of the htnfalpha transgenic mice. BMC Physiol.
2007;7:13
Hayward MD, Low MJ. The contribution of endogenous opioids to food reward is dependent on sex and
background strain. Neuroscience. 2007;144:17-25
Hayward MD, Schaich-Borg A, Pintar JE, Low MJ. Differential involvement of endogenous opioids in sucrose
consumption and food reinforcement. Pharmacology, Biochemistry and Behavior. 2006;85:601-611
He BC, Chen L, Zuo GW, Zhang W, Bi Y, Huang J, Wang Y, Jiang W, Luo Q, Shi Q, Zhang BQ, Liu B, Lei X, Luo J,
Luo X, Wagner ER, Kim SH, He CJ, Hu Y, Shen J, Zhou Q, Rastegar F, Deng ZL, Luu HH, He TC, Haydon RC.
Synergistic antitumor effect of the activated ppargamma and retinoid receptors on human osteosarcoma. Clin
Cancer Res. 2010;16:2235-2245
He BC, Gao JL, Luo X, Luo J, Shen J, Wang L, Zhou Q, Wang YT, Luu HH, Haydon RC, Wang CZ, Du W, Yuan CS,
He TC, Zhang BQ. Ginsenoside rg3 inhibits colorectal tumor growth through the down-regulation of wnt/sscatenin signaling. Int J Oncol. 2011;38:437-445
He BC, Gao JL, Zhang BQ, Luo Q, Shi Q, Kim SH, Huang E, Gao Y, Yang K, Wagner ER, Wang L, Tang N, Luo J, Liu
X, Li M, Bi Y, Shen J, Luther G, Hu N, Zhou Q, Luu HH, Haydon RC, Zhao Y, He TC. Tetrandrine inhibits wnt/betacatenin signaling and suppresses tumor growth of human colorectal cancer. Molecular pharmacology.
2011;79:211-219
He J, Rusckowski M, Wang Y, Dou S, Liu X, Zhang S, Liu G, Gupta S, Hnatowich D. Initial evidence for
pretargeting of tumor with fluorescence morpholino oligomers. J Nucl Med. 2006;47:508P
He J, Rusckowski M, Wang Y, Dou S, Liu X, Zhang S, Liu G, Hnatowich DJ. Optical pretargeting of tumor with
fluorescent morf oligomers. Molecular Imaging and Biology. 2007;9:17-23
He KHH, Brun T, Montet X, Duhamel D, Brighouse D, Herrera P, Meda P, Gauthier BR. A transgenic animal model
to study the role of pax4 in beta-cell plasticity by non-invasive in vivo imaging. Diabetes. 2008;57:A452
He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, Harding T, Jooss K, Takahashi T, Alitalo K.
Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for
tumor cell entry and spread via lymphatic vessels. Cancer Res. 2005;65:4739-4746
Hecker J, Hauck E, Nantz M, Tarantal A. Distribution, time course, in-vivo imaging, expression and inflammatory
response after non-viral gene delivery to rat and primate cns. Molecular Therapy. 2005;11:S223
Heeman B, Van den Haute C, Aelvoet SA, Valsecchi F, Rodenburg RJ, Reumers V, Debyser Z, Callewaert G,
Koopman WJ, Willems PH, Baekelandt V. Depletion of pink1 affects mitochondrial metabolism, calcium
homeostasis and energy maintenance. Journal of cell science. 2011;124:1115-1125
Heidel J, Hu S, Liu X, Triche T, Davis M. Lack of interferon response in animals to naked sirnas. Nature
Biotechnology. 2004;22:1579-1582
Heidel J, Hu-Lieskovan S, Bartlett D, Triche T, Davis M. Systemic administration of sirna against ews-fli1 using a
targeted, non-viral formulation inhibits growth in a disseminated murine model of ewing's sarcoma. Molecular
Therapy. 2005;11:S28-S29
Heidel JD, Liu JY, Yen Y, Zhou B, Heale BS, Rossi JJ, Bartlett DW, Davis ME. Potent sirna inhibitors of
ribonucleotide reductase subunit rrm2 reduce cell proliferation in vitro and in vivo. Clin Cancer Res.
2007;13:2207-2215
Heikkila JE, Vaha-Koskela MJ, Ruotsalainen JJ, Martikainen MW, Stanford MM, McCart JA, Bell JC, Hinkkanen
AE. Intravenously administered alphavirus vector va7 eradicates orthotopic human glioma xenografts in nude
mice. PLoS One. 2010;5:e8603
Heishi T, Hosaka T, Suzuki Y, Miyashita H, Oike Y, Takahashi T, Nakamura T, Arioka S, Mitsuda Y, Takakura T,
Hojo K, Matsumoto M, Yamauchi C, Ohta H, Sonoda H, Sato Y. Endogenous angiogenesis inhibitor vasohibin1
exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis. Am J Pathol.
2010
Heller L, Kowalski A, Butler C. Randomized, controlled, double-blind evaluation of local anesthetic infusion
pumps for donor site pain management following free tram flap breast reconstruction. Plastic and Reconstructive
Surgery. 2006;118:69
Hellums EK, Markert JM, Parker JN, He B, Perbal B, Roizman B, Whitley RJ, Langford CP, Bharara S, Gillespie GY.
Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma
model1. Neuro-oncol. 2005;7:213-224
Helms MW, Prescher JA, Cao YA, Schaffert S, Contag CH. Il-12 enhances efficacy and shortens enrichment time in
cytokine-induced killer cell immunotherapy. Cancer Immunol Immunother. 2010;59:1325-1334
Hemrajani C, Marches O, Wiles S, Girard F, Dennis A, Dziva F, Best A, Phillips AD, Berger CN, Mousnier A, Crepin
VF, Kruidenier L, Woodward MJ, Stevens MP, La Ragione RM, MacDonald TT, Frankel G. Role of nleh, a type iii
907.
908.
909.
910.
911.
912.
913.
914.
915.
916.
917.
918.
919.
920.
921.
922.
923.
924.
925.
926.
927.
928.
929.
930.
931.
secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut▿.
Infection and Immunity. 2008;76:4804-4813
Henderson YC, Chen Y, Frederick MJ, Lai SY, Clayman GL. Mek inhibitor pd0325901 significantly reduces the
growth of papillary thyroid carcinoma cells in vitro and in vivo. Mol Cancer Ther. 2010;9:1968-1976
Hendry SL, 2nd, van der Bogt KE, Sheikh AY, Arai T, Dylla SJ, Drukker M, McConnell MV, Kutschka I, Hoyt G,
Cao F, Weissman IL, Connolly AJ, Pelletier MP, Wu JC, Robbins RC, Yang PC. Multimodal evaluation of in vivo
magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells. J Thorac Cardiovasc
Surg. 2008;136:1028-1037 e1021
Henke E, Perk J, Vider J, de Candia P, Chin Y, Solit DB, Ponomarev V, Cartegni L, Manova K, Rosen N, Benezra R.
Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo. Nat
Biotechnol. 2008;26:91-100
Henken S, Bohling J, Martens-Lobenhoffer J, Paton JC, Ogunniyi AD, Briles DE, Salisbury VC, Wedekind D,
Bode-Boger SM, Welsh T, Bange FC, Welte T, Maus UA. Efficacy profiles of daptomycin for treatment of invasive
and noninvasive pulmonary infections with streptococcus pneumoniae. Antimicrob Agents Chemother.
2010;54:707-717
Henken S, Bohling J, Ogunniyi AD, Paton JC, Salisbury VC, Welte T, Maus UA. Evaluation of biophotonic
imaging to estimate bacterial burden in mice infected with highly virulent compared to less virulent
streptococcus pneumoniae serotypes. Antimicrob Agents Chemother. 2010;54:3155-3160
Henriquez NV, van Overveld PG, Que I, Buijs JT, Bachelier R, Kaijzel EL, Lowik CW, Clezardin P, van der Pluijm
G. Advances in optical imaging and novel model systems for cancer metastasis research. Clin Exp Metastasis.
2007;24:699-705
Henry M. Imaging and pharmacology. Nature Reviews Drug Discovery. 2003;2:123-131
Henry M, Silva M, Wen S, Siebert E, Solin E, Chandra S, Worland P. Spiculated periosteal response induced by
intraosseous injection of 22rv1 prostate cancer cells resembles subset of bone metastases in prostate cancer
patients. Prostate. 2005;65:347-354
Henshaw J, Mossop B, Yuan F. Relaxin treatment of solid tumors: Effects on electric field-mediated gene
delivery. Mol Cancer Ther. 2008;7:2566-2573
Henshaw J, Mossop B, Yuan F. Enhancement of electric field-mediated gene delivery through pretreatment of
tumors with a hyperosmotic mannitol solution. Cancer Gene Therapy. 2010
Henson B, Li F, Coatney D, Carey T, Mitra R, Kirkwood K, D'Silva N. An orthotopic floor-of-mouth model for
locoregional growth and spread of human squamous cell carcinoma. Journal of Oral Pathology and Medicine.
2007;36:363-370
Herbert Tran EE, Goodrich-Blair H. Cpxra contributes to xenorhabdus nematophila virulence through regulation
of lrha and modulation of insect immunity. Appl Environ Microbiol. 2009;75:3998-4006
Hernandez-Davies JE, Zape JP, Landaw EM, Tan X, Presnell A, Griffith D, Heinrich MC, Glaser KB, Sakamoto KM.
The multitargeted receptor tyrosine kinase inhibitor linifanib (abt-869) induces apoptosis through an akt and
glycogen synthase kinase 3beta-dependent pathway. Mol Cancer Ther. 2011;10:949-959
Hesselink JW, van Dam GM. [bioluminescence: The potential of a non-invasive bio-optical imaging technique
and improvement of animal research]. Tijdschr Diergeneeskd. 2007;132:244-250
Hickerson RP, Smith FJ, Reeves RE, Contag CH, Leake D, Leachman SA, Milstone LM, McLean WH, Kaspar RL.
Single-nucleotide-specific sirna targeting in a dominant-negative skin model. Journal of Investigative
Dermatology. 2008;128:594-605
Hickerson RP, Vlassov AV, Wang Q, Leake D, Ilves H, Gonzalez-Gonzalez E, Contag CH, Johnston BH, Kaspar RL.
Stability study of unmodified sirna and relevance to clinical use. Oligonucleotides. 2008;18:345-354
Hickson J, Ackler S, Klaubert D, Bouska J, Ellis P, Foster K, Oleksijew A, Rodriguez L, Schlessinger S, Wang B,
Frost D. Noninvasive molecular imaging of apoptosis in vivo using a modified firefly luciferase substrate, zdevd-aminoluciferin. Cell Death Differ. 2010
Highfill SL, Kelly RM, O'Shaughnessy MJ, Zhou Q, Xia L, Panoskaltsis-Mortari A, Taylor PA, Tolar J, Blazar BR.
Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin e2 synthesis and
only if localized to sites of allopriming. Blood. 2009;114:693-701
Hikichi M, Kidokoro M, Haraguchi T, Iba H, Shida H, Tahara H, Nakamura T. Microrna regulation of glycoprotein
b5r in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy. Molecular
therapy : the journal of the American Society of Gene Therapy. 2011;19:1107-1115
Hildebrandt I, Czernin J, Weber W. Reproducibility of fdg micropet, firefly and renilla luciferase
bioluminescence imaging measurements in tumor bearing mice. J Nucl Med. 2006;47:425P
Hildebrandt IJ, Gambhir SS. Molecular imaging applications for immunology. Clin Immunol. 2004;111:210-224
Hildebrandt IJ, Iyer M, Wagner E, Gambhir SS. Optical imaging of transferrin targeted pei/DNA complexes in
living subjects. Gene Therapy. 2003;10:758-764
Hiley CT, Yuang M, Lemoine NR, Wang Y. Lister strain vaccinia virus, a potential therapeutic vector targeting
hypoxic tumours. Gene Therapy. 2010;17:281-287
Hillman EMC, Moore A. All-optical anatomical co-registration for molecular imaging of small animals using
dynamic contrast. Nat Photonics. 2007;1:526-530
Hingorani M, White CL, Merron A, Peerlinck I, Gore ME, Slade A, Scott SD, Nutting CM, Pandha HS, Melcher AA,
Vile RG, Vassaux G, Harrington KJ. Inhibition of repair of radiation-induced DNA damage enhances gene
932.
933.
934.
935.
936.
937.
938.
939.
940.
941.
942.
943.
944.
945.
946.
947.
948.
949.
950.
951.
952.
953.
954.
955.
956.
expression from replication-defective adenoviral vectors. Cancer Res. 2008;68:9771-9778
Hingorani M, White CL, Zaidi S, Merron A, Peerlinck I, Gore ME, Nutting CM, Pandha HS, Melcher AA, Vile RG,
Vassaux G, Harrington KJ. Radiation-mediated up-regulation of gene expression from replication-defective
adenoviral vectors: Implications for sodium iodide symporter gene therapy. Clin Cancer Res.
2008;14:4915-4924
Hingtgen SD, Li Z, Kutschke W, Tian X, Sharma RV, Davisson RL. Superoxide scavenging and akt inhibition in
the myocardium ameliorate pressure overload-induced nf{kappa}b activation and cardiac hypertrophy. Physiol
Genomics. 2010
Hino A, Fukuyama S, Kataoka K, Kweon MN, Fujihashi K, Kiyono H. Nasal il-12p70 DNA prevents and treats
intestinal allergic diarrhea. J Immunol. 2005;174:7423-7432
Hiraoka K, Kimura T, Logg CR, Kasahara N. Tumor-selective gene expression in a hepatic metastasis model after
locoregional delivery of a replication-competent retrovirus vector. Clin Cancer Res. 2006;12:7108-7116
Hiraoka K, Kimura T, Logg CR, Tai CK, Haga K, Lawson GW, Kasahara N. Therapeutic efficacy of replicationcompetent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model.
Cancer Res. 2007;67:5345-5353
Hirbe AC, Roelofs AJ, Floyd DH, Deng H, Becker SN, Lanigan LG, Apicelli AJ, Xu Z, Prior JL, Eagleton MC,
Piwnica-Worms D, Rogers MJ, Weilbaecher K. The bisphosphonate zoledronic acid decreases tumor growth in
bone in mice with defective osteoclasts. Bone. 2009;44:908-916
Hirbe AC, Rubin J, Uluçkan Ö, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, Weilbaecher KN. Disruption
of cxcr4 enhances osteoclastogenesis and tumor growth in bone. Proceedings of the National Academy of
Sciences of the United States of America. 2007;104:14062-14067
Hirbe AC, Uluçkan Ö, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, Trinkaus K, Apicelli A, Weilbaecher
K. Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent
manner. Blood. 2007;109:3424-3431
Hirota K, Sakamaki J, Ishida J, Shimamoto Y, Nishihara S, Kodama N, Ohta K, Yamamoto M, Tanimoto K,
Fukamizu A. A combination of hnf-4 and foxo1 is required for reciprocal transcriptional regulation of
glucokinase and glucose-6-phosphatase genes in response to fasting and feeding. J Biol Chem.
2008;283:32432-32441
Hirst SM, Karakoti A, Singh S, Self W, Tyler R, Seal S, Reilly CM. Bio-distribution and in vivo antioxidant
effects of cerium oxide nanoparticles in mice. Environmental toxicology. 2011
Hitziger N, Dellacasa I, Albiger B, Barragan A. Dissemination of toxoplasma gondii to immunoprivileged organs
and role of toll/interleukin 1 receptor signalling for host resistance assessed by in vivo bioluminescence
imaging. Cellular Microbiology. 2005;7:837-848
Hix J, Braun W, Isada C. Delirium in a renal transplant recipient associated with bk virus in the cerebrospinal
fluid. Transplantation. 2004;78:1407
Ho G, Kumar S, Zhang C, Kng YL, Zhuo L. Molecular imaging reveals a correlation between 2'-ch3-mptp-induced
neonatal neurotoxicity and dopaminergic neurodegeneration in adult transgenic mice. Int J Dev Neurosci.
2008;26:673-681
Ho G, Zhang C, Zhuo L. Non-invasive fluorescent imaging of gliosis in transgenic mice for profiling
developmental neurotoxicity. Toxicol Appl Pharmacol. 2007;221:76-85
Ho TY, Chen YS, Hsiang CY. Noninvasive nuclear factor-kappab bioluminescence imaging for the assessment of
host-biomaterial interaction in transgenic mice. Biomaterials. 2007;28:4370-4377
Hod EA, Zhang N, Sokol SA, Wojczyk BS, Francis RO, Ansaldi D, Francis KP, Della-Latta P, Whittier S, Sheth S,
Hendrickson JE, Zimring JC, Brittenham GM, Spitalnik SL. Transfusion of red blood cells after prolonged storage
produces harmful effects that are mediated by iron and inflammation. Blood. 2010;115:4284-4292
Hodgson MM, Day B, White DJ, Tisa LS. Effect of growth conditions on the motility of photorhabdus temperata.
Archives of Microbiology. 2003;180:17-24
Hoebe K, Georgel P, Rutschmann S, Du X, Mudd S, Crozat K, Sovath S, Shamel L, Hartung T, Zähringer U. Cd36 is
a sensor of diacylglycerides. Nature. 2005;433:523-527
Hoehn M, Himmelreich U, Kruttwig K, Wiedermann D. Molecular and cellular mr imaging: Potentials and
challenges for neurological applications. J Magn Reson Imaging. 2008;27:941-954
Hoffmann W, Oberheitmann B, Frentzel-Beyme R. "Host factors"--evolution of concepts of individual sensitivity
and susceptibility. Int J Hyg Environ Health. 2001;204:5-15
Hofmann-Sieber H, Wild J, Fiedler N, Tischer K, von Einem J, Osterrieder N, Hofmann H, Köstler J, Wagner R.
Impact of etif deletion on safety and immunogenicity of equine herpesvirus type 1-vectored vaccines ▿‡. J Virol.
2010;84:11602-11613
Hokaiwado N, Takeshita F, Naiki-Ito A, Asamoto M, Ochiya T, Shirai T. Glutathione s-transferase pi mediates
proliferation of androgen-independent prostate cancer cells. Carcinogenesis. 2008;29:1134-1138
Holland DB, Bojar RA, Jeremy AH, Ingham E, Holland KT. Microbial colonization of an in vitro model of a tissue
engineered human skin equivalent--a novel approach. FEMS Microbiol Lett. 2008;279:110-115
Holland JP, Normand G, Ruggiero A, Lewis JS, Grimm J. Intraoperative imaging of positron emission
tomographic radiotracers using cerenkov luminescence emissions. Molecular imaging. 2011;10:177-186,
171-173
Holland SJ, Pan A, Franci C, Hu Y, Chang B, Li W, Duan M, Torneros A, Yu J, Heckrodt TJ, Zhang J, Ding P,
957.
958.
959.
960.
961.
962.
963.
964.
965.
966.
967.
968.
969.
970.
971.
972.
973.
974.
975.
976.
977.
978.
979.
980.
981.
982.
Apatira A, Chua J, Brandt R, Pine P, Goff D, Singh R, Payan DG, Hitoshi Y. R428, a selective small molecule
inhibitor of axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer
Res. 2010;70:1544-1554
Holopainen T, Huang H, Chen C, Kim KE, Zhang L, Zhou F, Han W, Li C, Yu J, Wu J, Koh GY, Alitalo K, He Y.
Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and
metastasis establishment. Cancer Res. 2009;69:4656-4664
Hong S, Jeong J, Lee Y, Jung H, Kim K, Kim Y, Lee Y, Lee S, Bae C, Park J. Molecular imaging of endogenous mrna
expression in a mouse tumor model by adenovirus harboring trans-splicing ribozyme. FEBS Letters.
2007;581:5396-5400
Hood JL, Pan H, Lanza GM, Wickline SA. Paracrine induction of endothelium by tumor exosomes. Lab Invest.
2009;89:1317-1328
Hood JL, San RS, Wickline SA. Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor
metastasis. Cancer Res. 2011;71:3792-3801
Hopkin K. Glowing mice illuminate gene expression patterns. The Journal of NIH Research. 1997;9
Horie M, Sekiya I, Muneta T, Ichinose S, Matsumoto K, Saito H, Murakami T, Kobayashi E. Intra-articular injected
synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without
mobilization to distant organs in rat massive meniscal defect. Stem Cells. 2009;27:878-887
Hosoda A, Tokuda M, Akai R, Kohno K, Iwawaki T. Positive contribution of erdj5/jpdi to endoplasmic reticulum
protein quality control in the salivary gland. Biochem J. 2009
Hosoyama T, Nishijo K, Prajapati SI, Li G, Keller C. Rb1 gene inactivation expands satellite cell and postnatal
myoblast pools. The Journal of biological chemistry. 2011;286:19556-19564
Hovav AH, Cayabyab MJ, Panas MW, Santra S, Greenland J, Geiben R, Haynes BF, Jacobs WR, Letvin NL. Rapid
memory cd8+ t-lymphocyte induction through priming with recombinant mycobacterium smegmatis▿. J Virol.
2007;81:74-83
Hovav AH, Panas MW, Osuna CE, Cayabyab MJ, Autissier P, Letvin NL. The impact of a boosting immunogen on
the differentiation of secondary memory cd8+ t cells▿. J Virol. 2007;81:12793-12802
Hovav AH, Panas MW, Rahman S, Sircar P, Gillard G, Cayabyab MJ, Letvin NL. Duration of antigen expression in
vivo following DNA immunization modifies the magnitude, contraction, and secondary responses of cd8+ t
lymphocytes1. Journal of Immunology. 2007;179:6725-6733
Hovav AH, Santosuosso M, Bivas-Benita M, Plair A, Cheng A, Elnekave M, Righi E, Chen T, Kashiwagi S, Panas
MW, Xiang SH, Furmanov K, Letvin NL, Poznansky MC. X4 human immunodeficiency virus type 1 gp120 downmodulates expression and immunogenicity of codelivered antigens▿. J Virol. 2009;83:10941-10950
Howe K, Karsi A, Germon P, Wills RW, Lawrence ML, Bailey RH. Development of stable reporter system cloning
luxcdabe genes into chromosome of salmonella enterica serotypes using tn7 transposon. BMC Microbiol.
2010;10:197
Hoyos V, Savoldo B, Quintarelli C, Mahendravada A, Zhang M, Vera J, Heslop HE, Rooney CM, Brenner MK, Dotti
G. Engineering cd19-specific t lymphocytes with interleukin-15 and a suicide gene to enhance their antilymphoma/leukemia effects and safety. Leukemia. 2010;24:1160-1170
Hrusovsky K. Getting on the critical path: Better evaluation tools for drug discovery and development. Drug
Discovery Today. 2006;11:773-774
Hseu Y, Huang H, Hsiang C. Antrodia camphorata suppresses lipopolysaccharide-induced nuclear factor-[kappa]
b activation in transgenic mice evaluated by bioluminescence imaging. Food and Chemical Toxicology. 2010
Hsiang CY, Chen YS, Ho TY. Nuclear factor-kappab bioluminescence imaging-guided transcriptomic analysis for
the assessment of host-biomaterial interaction in vivo. Biomaterials. 2009;30:3042-3049
Hsiang SW, Tsai CC, Tsai FJ, Ho TY, Yao CH, Chen YS. Novel use of biodegradable casein conduits for guided
peripheral nerve regeneration. Journal of the Royal Society, Interface / the Royal Society. 2011
Hsieh C, Xie Z, Yu J, Martin W, Datta M, Wu G, Chung L. Non invasive bioluminescent detection of prostate
cancer growth and metastasis in a bigenic transgenic mouse model. Prostate. 2007;67:685-691
Hsieh CL, Xie Z, Liu ZY, Green JE, Martin WD, Datta MW, Yeung F, Pan D, Chung LWK. A luciferase transgenic
mouse model: Visualization of prostate development and its androgen responsiveness in live animals. J Mol
Endocrinol. 2005;35:293-304
Hsieh CL, Xie Z, Yu J, Martin WD, Datta MW, Wu GJ, Chung LW. Non-invasive bioluminescent detection of
prostate cancer growth and metastasis in a bigenic transgenic mouse model. Prostate. 2007;67:685-691
Hsieh SR, Chang CJ, Way TD, Kwan PC, Hung TW. Preparation and non-invasive in-vivo imaging of antiadhesion barriers with fluorescent polymeric marks. J Fluoresc. 2009;19:733-740
Hsieh YJ, Chen FD, Ke CC, Wang HE, Huang CJ, Hou MF, Lin KP, Gelovani JG, Liu RS. The eiiapa chimeric
promoter for tumor specific gene therapy of hepatoma. Molecular imaging and biology : MIB : the official
publication of the Academy of Molecular Imaging. 2011
Hsu AR, Cai W, Veeravagu A, Mohamedali KA, Chen K, Kim S, Vogel H, Hou LC, Tse V, Rosenblum MG, Chen X.
Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin
vegf121/rgel. J Nucl Med. 2007;48:445-454
Hsu AR, Hou LC, Veeravagu A, Greve JM, Vogel H, Tse V, Chen X. In vivo near-infrared fluorescence imaging of
integrin (alpha)v(beta)3 in an orthotopic glioblastoma model. Molecular Imaging and Biology. 2006;8:315-323
Hsu M, Muchova L, Morioka I, Wong RJ, Schroder H, Stevenson DK. Tissue-specific effects of statins on the
expression of heme oxygenase-1 in vivo. Biochem Biophys Res Commun. 2006;343:738-744
Hsu SH, Wen CJ, Al-Suwayeh SA, Chang HW, Yen TC, Fang JY. Physicochemical characterization and in vivo
bioluminescence imaging of nanostructured lipid carriers for targeting the brain: Apomorphine as a model drug.
Nanotechnology. 2010;21:405101
984.
Hu J, Ljubimova JY, Inoue S, Konda B, Patil R, Ding H, Espinoza A, Wawrowsky KA, Patil C, Ljubimov AV, Black
KL. Phosphodiesterase type 5 inhibitors increase herceptin transport and treatment efficacy in mouse metastatic
brain tumor models. PLoS One. 2010;5
985.
Hu S, Heidel J, Barlett D, Kohn D, Davis M, Triche T. Systemic targeted ews-fli1 sirna abrogates growth of
metastases in a murine ewing's tumor model. Proceedings of the American Association for Cancer Research.
2005;2005:1435
986.
Hu Y, Turner MJ, Shields J, Gale MS, Hutto E, Roberts BL, Siders WM, Kaplan JM. Investigation of the
mechanism of action of alemtuzumab in a human cd52 transgenic mouse model. Immunology. 2009;128:260-270
987.
Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. Sequence-specific knockdown of ews-fli1 by
targeted, nonviral delivery of small interfering rna inhibits tumor growth in a murine model of metastatic ewing's
sarcoma. Cancer Res. 2005;65:8984-8992
988.
Huang B, Mao CP, Peng S, He L, Hung CF, Wu TC. Intradermal administration of DNA vaccines combining a
strategy to bypass antigen processing with a strategy to prolong dendritic cell survival enhances DNA vaccine
potency. Vaccine. 2007;25:7824-7831
989.
Huang B, Mao CP, Peng S, Hung CF, Wu TC. Rna interference-mediated in vivo silencing of fas ligand as a
strategy for the enhancement of DNA vaccine potency. Human Gene Therapy. 2008;19:763-773
990.
Huang CW, Li Z, Cai H, Chen K, Shahinian T, Conti PS. Design, synthesis and validation of integrin alpha2beta1targeted probe for micropet imaging of prostate cancer. European journal of nuclear medicine and molecular
imaging. 2011;38:1313-1322
991.
Huang E, Singh B, Cristofanilli M, Gelovani J, Wei C, Vincent L, Cook K, Lucci A. A cxcr4 antagonist ctce-9908
inhibits primary tumor growth and metastasis of breast cancer1. Journal of Surgical Research.
2009;155:231-236
992.
Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC. Short hairpin rna
interference therapy for ischemic heart disease. Circulation. 2008;118:S226-233
993.
Huang M, Wu JC. Molecular imaging of rna interference therapy targeting phd2 for treatment of myocardial
ischemia. Methods Mol Biol. 2011;709:211-221
994.
Huang NF, Niiyama H, De A, Gambhir SS, Cooke JP. Embryonic stem cell-derived endothelial cells for treatment
of hindlimb ischemia. J Vis Exp. 2009
995.
Huang NF, Niiyama H, Peter C, De A, Natkunam Y, Fleissner F, Li Z, Rollins MD, Wu JC, Gambhir SS, Cooke JP.
Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion.
Arterioscler Thromb Vasc Biol. 2011
;30:984-991
996.
Huang P, Kaku H, Chen J, Kashiwakura Y, Saika T, Nasu Y, Urata Y, Fujiwara T, Watanabe M, Kumon H. Potent
antitumor effects of combined therapy with a telomerase-specific, replication-competent adenovirus (obp-301)
and il-2 in a mouse model of renal cell carcinoma. Cancer Gene Ther. 2010
997.
Huang W, Wu D, Xie Z, Zhau H, Nomura T, Zayzafoon M, Pohl J, Hsieh C, Weitzmann M, Farach-Carson M. Beta2microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis. Cancer
Res. 2006;66:9108
998.
Huang X, Guo H, Kang J, Choi S, Zhou TC, Tammana S, Lees CJ, Li ZZ, Milone M, Levine BL, Tolar J, June CH,
Scott McIvor R, Wagner JE, Blazar BR, Zhou X. Sleeping beauty transposon-mediated engineering of human
primary t cells for therapy of cd19+ lymphoid malignancies. Mol Ther. 2008;16:580-589
999.
Huang Y, Song N, Ding Y, Yuan S, Li X, Cai H, Shi H, Luo Y. Pulmonary vascular destabilization in the
premetastatic phase facilitates lung metastasis. Cancer Res. 2009;69:7529-7537
1000.
Huang YH, Bao Y, Peng W, Goldberg M, Love K, Bumcrot DA, Cole G, Langer R, Anderson DG, Sawicki JA.
Claudin-3 gene silencing with sirna suppresses ovarian tumor growth and metastasis. Proc Natl Acad Sci U S A.
2009;106:3426-3430
1001.
Huang YH, Chin CC, Ho HN, Chou CK, Shen CN, Kuo HC, Wu TJ, Wu YC, Hung YC, Chang CC, Ling TY.
Pluripotency of mouse spermatogonial stem cells maintained by igf-1- dependent pathway. Faseb J. 2009
1002.
Huang YH, Zugates GT, Peng W, Holtz D, Dunton C, Green JJ, Hossain N, Chernick MR, Padera RF, Jr., Langer R,
Anderson DG, Sawicki JA. Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden
in mice. Cancer Res. 2009;69:6184-6191
1003.
Huarte E, Cubillos-Ruiz JR, Nesbeth YC, Scarlett UK, Martinez DG, Buckanovich RJ, Benencia F, Stan RV, Keler T,
Sarobe P, Sentman CL, Conejo-Garcia JR. Depletion of dendritic cells delays ovarian cancer progression by
boosting antitumor immunity. Cancer Res. 2008;68:7684-7691
1004.
Huarte E, Larrea E, Hernández-Alcoceba R, Alfaro C, Murillo O, Arina A, Tirapu I, Azpilicueta A, Hervás-Stubbs S,
Bortolanza S. Recombinant adenoviral vectors turn on the type i interferon system without inhibition of
transgene expression and viral replication. Molecular Therapy. 2006;14:129-138
1005.
Hubbard VM, Eng JM, Ramirez-Montagut T, Tjoe KH, Muriglan SJ, Kochman AA, Terwey TH, Willis LM, Schiro R,
Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MRM. Absence of inducible costimulator on alloreactive
t cells reduces graft versus host disease and induces th2 deviation. Blood. 2005;106:3285-3292
983.
1006.
1007.
1008.
1009.
1010.
1011.
1012.
1013.
1014.
1015.
1016.
1017.
1018.
1019.
1020.
1021.
1022.
1023.
1024.
1025.
1026.
1027.
1028.
1029.
1030.
1031.
Huch M, Abate-Daga D, Roig J, González J, Fabregat J, Sosnowski B, Mazo A, Fillat C. Targeting the cyp2b1/
cyclophosphamide suicide system to fibroblast growth factor receptors results in a potent antitumoral response
in pancreatic cancer models. Human Gene Therapy. 2006;17:1187-1200
Huch M, Gros A, José A, González JR, Alemany R, Fillat C. Urokinase-type plasminogen activator receptor
transcriptionally controlled adenoviruses eradicate pancreatic tumors and liver metastasis in mouse models12.
Neoplasia. 2009;11:518-528
Hudson KJ, Bouton AH. Yersinia pseudotuberculosis adhesins regulate tissue-specific colonization and immune
cell localization in a mouse model of systemic infection▿†. Infection and Immunity. 2006;74:6487-6490
Huerta S, Gao X, Saha D. Murine orthotopic model for the assessment of chemoradiotherapeutic interventions in
rectal cancer. Anti-cancer drugs. 2011;22:371-376
Humbey O, Pimkina J, Zilfou JT, Jarnik M, Dominguez-Brauer C, Burgess DJ, Eischen CM, Murphy ME. The arf
tumor suppressor can promote the progression of some tumors. Cancer Res. 2008;68:9608-9613
Hundt W, O'Connell-Rodwell C, Bednarski M, Steinbach S, Guccione S. In vitro effect of focused ultrasound or
thermal stress on hsp70 expression and cell viability in three tumor cell lines. Academic Radiology.
2007;14:859-870
Hundt W, Steinbach S, Mayer D, Bednarski MD. Modulation of luciferase activity using high intensity focused
ultrasound in combination with bioluminescence imaging, magnetic resonance imaging and histological
analysis in muscle tissue. Ultrasonics. 2009;49:549-557
Hundt W, Steinbach S, O'Connell-Rodwell CE, Bednarski MD, Guccione S. The effect of high intensity focused
ultrasound on luciferase activity on two tumor cell lines in vitro, under the control of a cmv promoter.
Ultrasonics. 2009;49:312-318
Hundt W, Steinbach S, O'Connell-Rodwell CE, Mayer D, Bednarski MD, Guccione S. Tumor tissue
characterization evaluating the luciferase activity under the control of a hsp70 promoter and mr imaging in three
tumor cell lines. European Journal of Radiology. 2009;70:369-377
Hung CF, Tsai YC, He L, Coukos G, Fodor I, Qin L, Levitsky H, Wu TC. Vaccinia virus preferentially infects and
controls human and murine ovarian tumors in mice. Gene Ther. 2007;14:20-29
Hung CF, Tsai YC, He L, Wu TC. Control of mesothelin-expressing ovarian cancer using adoptive transfer of
mesothelin peptide-specific cd8(+) t cells. Gene Ther. 2007
Hunter J, Neben T, Purchio T, Jenkins D. Bioluminescent monitoring of ovarian carcinoma growth and spread in
mouse xenograft tumor models. Proceedings of the American Association for Cancer Research. 2005;2005:256
Hurtado A, Tseng J, Boivin C, Levin B, Yee H, Pampeno C, Meruelo D. Identification of amino acids of sindbis
virus e2 protein involved in targeting tumor metastases in vivo. Molecular Therapy. 2005;12:813-823
Hurtado A, Tseng JC, Meruelo D. Gene therapy that safely targets and kills tumor cells throughout the body.
Rejuvenation Res. 2006;9:36-44
Hussey GS, Chaudhury A, Dawson AE, Lindner DJ, Knudsen CR, Wilce MC, Merrick WC, Howe PH. Identification
of an mrnp complex regulating tumorigenesis at the translational elongation step. Molecular cell.
2011;41:419-431
Hutchens M, Luker GD. Applications of bioluminescence imaging to the study of infectious diseases. Cell
Microbiol. 2007;9:2315-2322
Hutchens M, Luker KE, Sottile P, Sonstein J, Lukacs NW, Nunez G, Curtis JL, Luker GD. Tlr3 increases disease
morbidity and mortality from vaccinia infection. J Immunol. 2008;180:483-491
Hutteman M, Mieog JS, van der Vorst JR, Dijkstra J, Kuppen PJ, van der Laan AM, Tanke HJ, Kaijzel EL, Que I, van
de Velde CJ, Lowik CW, Vahrmeijer AL. Intraoperative near-infrared fluorescence imaging of colorectal
metastases targeting integrin alpha(v)beta(3) expression in a syngeneic rat model. Eur J Surg Oncol.
2011;37:252-257
Hutter E, Boridy S, Labrecque S, Lalancette-Hebert M, Kriz J, Winnik FM, Maysinger D. Microglial response to
gold nanoparticles. ACS Nano. 2010;4:2595-2606
Huynh AS, Abrahams DF, Torres MS, Baldwin MK, Gillies RJ, Morse DL. Development of an orthotopic human
pancreatic cancer xenograft model using ultrasound guided injection of cells. PloS one. 2011;6:e20330
Huynh C, Segura MF, Gaziel-Sovran A, Menendez S, Darvishian F, Chiriboga L, Levin B, Meruelo D, Osman I,
Zavadil J, Marcusson EG, Hernando E. Efficient in vivo microrna targeting of liver metastasis. Oncogene.
2011;30:1481-1488
Huysentruyt L, Shelton L, Seyfried T. Influence of methotrexate and cisplatin on tumor progression and survival
in the vm mouse model of systemic metastatic cancer. International Journal of Cancer. 2010;126:65-72
Huysentruyt LC, Mukherjee P, Banerjee D, Shelton LM, Seyfried TN. Metastatic cancer cells with macrophage
properties: Evidence from a new murine tumor model. Int J Cancer. 2008;123:73-84
Hwang do W, Song IC, Lee DS, Kim S. Smart magnetic fluorescent nanoparticle imaging probes to monitor
micrornas. Small. 2010;6:81-88
Hwang DW, Jang SJ, Kim YH, Kim HJ, Shim IK, Jeong JM, Chung JK, Lee MC, Lee SJ, Kim SU, Kim S, Lee DS.
Real-time in vivo monitoring of viable stem cells implanted on biocompatible scaffolds. Eur J Nucl Med Mol
Imaging. 2008
Hwang NS, Varghese S, Lee HJ, Zhang Z, Ye Z, Bae J, Cheng L, Elisseeff J. In vivo commitment and functional
tissue regeneration using human embryonic stem cell-derived mesenchymal cells. Proceedings of the National
Academy of Sciences of the United States of America. 2008;105:20641-20646
1032.
1033.
1034.
1035.
1036.
1037.
1038.
1039.
1040.
1041.
1042.
1043.
1044.
1045.
1046.
1047.
1048.
1049.
1050.
1051.
1052.
1053.
1054.
1055.
Hwang S, Wu TT, Tong LM, Kim KS, Martinez-Guzman D, Colantonio AD, Uittenbogaart CH, Sun R. Persistent
gammaherpesvirus replication and dynamic interaction with the host in vivo. J Virol. 2008;82:12498-12509
Hyland KV, Asfaw SH, Olson CL, Daniels MD, Engman DM. Bioluminescent imaging of trypanosoma cruzi
infection. International Journal for Parasitology. 2008;38:1391-1400
Iankov ID, Msaouel P, Allen C, Federspiel MJ, Bulur PA, Dietz AB, Gastineau D, Ikeda Y, Ingle JN, Russell SJ,
Galanis E. Demonstration of anti-tumor activity of oncolytic measles virus strains in a malignant pleural
effusion breast cancer model. Breast Cancer Res Treat. 2010;122:745-754
Ibarra JM, Jimenez F, Martinez HG, Clark K, Ahuja SS. Mmp-activated fluorescence imaging detects early joint
inflammation in collagen-antibody-induced arthritis in cc-chemokine receptor-2-null mice, in-vivo.
International journal of inflammation. 2011;2011:691587
Ibrahim-Granet O, Jouvion G, Hohl TM, Droin-Bergère S, Philippart F, Kim OY, Adib-Conquy M, Schwendener R,
Cavaillon JM, Brock M. In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct
roles for resident and recruited immune effector cells in defense against invasive aspergillosis. BMC Microbiol.
2010;10:105
Ibrahimi A, Vande Velde G, Reumers V, Toelen J, Thiry I, Vandeputte C, Vets S, Deroose C, Bormans G, Baekelandt
V, Debyser Z, Gijsbers R. Highly efficient multicistronic lentiviral vectors with peptide 2a sequences. Hum Gene
Ther. 2009;20:845-860
Iclozan C, Yu Y, Liu C, Liang Y, Yi T, Anasetti C, Yu XZ. Th17 cells are sufficient but not necessary to induce
acute graft-versus-host disease. Biol Blood Marrow Transplant. 2009
Iglesias P, Costoya JA. A novel bret-based genetically encoded biosensor for functional imaging of hypoxia.
Biosens Bioelectron. 2009;24:3126-3130
Ikeda AK, Judelson DR, Federman N, Glaser KB, Landaw EM, Denny CT, Sakamoto KM. Abt-869 inhibits the
proliferation of ewing sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-kit
signaling pathways. Mol Cancer Ther. 2010;9:653-660
Ikegami T, Nakamura M, Yamane J, Katoh H, Okada S, Iwanami A, Watanabe K, Ishii K, Kato F, Fujita H.
Chondroitinase abc combined with neural stem/progenitor cell transplantation enhances graft cell migration and
outgrowth of growth associated protein 43 positive fibers after rat spinal cord injury. European Journal of
Neuroscience. 2005;22:3036-3046
Ilagan R, Pottratz J, Le K, Wong S, Ayala R, Slamon D, Carey M. Bioluminescence imaging of ar and mapk activity
in androgen independent prostate cancer xenografts. Proceedings of the American Association for Cancer
Research. 2005;2005:459
Ilagan R, Pottratz J, Le K, Zhang L, Wong SG, Ayala R, Iyer M, Wu L, Gambhir SS, Carey M. Imaging mitogenactivated protein kinase function in xenograft models of prostate cancer. Cancer Res. 2006;66:10778-10785
Ilagan R, Zhang L, Pottratz J, Le K, Salas S, Iyer M, Wu L, Gambhir S, Carey M. Imaging androgen receptor
function during flutamide treatment in the lapc9 xenograft model. Mol Cancer Ther. 2005;4:1662
Ilagan RS, Zhang LJ, Le KH, Carey M. Interrogating androgen receptor and mapk function in androgen
independent prostate cancer by optical imaging with two-step transcription amplification systems. Proceedings
of the American Association for Cancer Research Annual Meeting. 2004;45:48
Ilkovitch D, Handel-Fernandez ME, Herbert LM, Lopez DM. Antitumor effects of mucin 1/sec involves the
modulation of urokinase-type plasminogen activator and signal transducer and activator of transcription 1
expression in tumor cells. Cancer Res. 2008;68:2427-2435
Ilkovitch D, Lopez DM. The liver is a site for tumor-induced myeloid-derived suppressor cell accumulation and
immunosuppression. Cancer Res. 2009;69:5514-5521
Ilnytska O, Sözen MA, Dauterive R, Argyropoulos G. Control elements in the neighboring atpase gene influence
spatiotemporal expression of the human agouti-related protein. Journal of Molecular Biology.
2009;388:239-251
Ilnytska O, Stutz AM, Park-York M, York DA, Ribnicky DM, Zuberi A, Cefalu WT, Argyropoulos G. Molecular
mechanisms for activation of the agouti-related protein and stimulation of appetite. Diabetes. 2011;60:97-106
ILVES H, KASPAR R, WANG Q, SEYHAN A, VLASSOV A, CONTAG C, LEAKE D, JOHNSTON B. Inhibition of
hepatitis c ires-mediated gene expression by small hairpin rnas in human hepatocytes and mice. Annals of the
New York Academy of Sciences. 2006;1082:52-55
Infanger DW, Kutschke W, Peterson JR, Sharma RV, Davisson RL. In vivo bioluminescent imaging reveals
myocardial infarction (mi)-induced activation of the inducible transcription factor nf kappa b in mouse brain.
FASEB Journal. 2005;19:A1292
Infanger DW, Peterson JR, Sharma RV, Davisson RL. Long-term in vivo monitoring of transcription factor (tf)
activation in cardiovascular (cv) control regions of mouse brain using bioluminescence imaging (bli). FASEB
Journal. 2007;21:A1412
Inglefield JR, Dumitru CD, Alkan SS, Gibson SJ, Lipson KE, Tomai MA, Larson CJ, Vasilakos JP. Tlr7 agonist
852a inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type i ifn. J
Interferon Cytokine Res. 2008;28:253-263
Inoue H, Murakami T, Ajiki T, Hara M, Hoshino Y, Kobayashi E. Bioimaging assessment and effect of skin wound
healing using bone-marrow-derived mesenchymal stromal cells with the artificial dermis in diabetic rats. Journal
of biomedical optics. 2008;13:064036
Inoue H, Ohsawa I, Murakami T, Kimura A, Hakamata Y, Sato Y, Kaneko T, Takahashi M, Okada T, Ozawa K.
Development of new inbred transgenic strains of rats with lacz or gfp. Biochemical and Biophysical Research
Communications. 2005;329:288-295
1056.
Inoue S, Ding H, Portilla-Arias J, Hu J, Konda B, Fujita M, Espinoza A, Suhane S, Riley M, Gates M, Patil R,
Penichet ML, Ljubimov AV, Black KL, Holler E, Ljubimova JY. Polymalic acid-based nanobiopolymer provides
efficient systemic breast cancer treatment by inhibiting both her2/neu receptor synthesis and activity. Cancer
Res. 2011;71:1454-1464
1057.
Inoue S, Golseiz H, Patil R, Ding H, Rudenkyy S, Holler E, Black KL, Ljubimova JY. Direct tumor targeting using
nanobioconjugate with a combination of monoclonal antibodies for breast cancer treatment. Cancer Res.
2009;69
1058.
Inoue Y, Izawa K, Kiryu S, Kobayashi S, Tojo A, Ohtomo K. Bioluminescent evaluation of the therapeutic effects
of total body irradiation in a murine hematological malignancy model. Exp Hematol. 2008;36:1634-1641
1059.
Inoue Y, Izawa K, Kiryu S, Tojo A, Ohtomo K. Diet and abdominal autofluorescence detected by in vivo
fluorescence imaging of living mice. Mol Imaging. 2008;7:21-27
1060.
Inoue Y, Izawa K, Tojo A, Nomura Y, Sekine R, Oyaizu N, Ohtomo K. Monitoring of disease progression by
bioluminescence imaging and magnetic resonance imaging in an animal model of hematologic malignancy. Exp
Hematol. 2007;35:407-415
1061.
Inoue Y, Izawa K, Yoshikawa K, Yamada H, Tojo A, Ohtomo K. In vivo fluorescence imaging of the
reticuloendothelial system using quantum dots in combination with bioluminescent tumour monitoring. Eur J
Nucl Med Mol Imaging. 2007
1062.
Inoue Y, Kiryu S, Izawa K, Watanabe M, Tojo A, Ohtomo K. Comparison of subcutaneous and intraperitoneal
injection of d-luciferin for in vivo bioluminescence imaging. European Journal of Nuclear Medicine and
Molecular Imaging. 2009;36:771-779
1063.
Inoue Y, Kiryu S, Watanabe M, Oyaizu N, Ohtomo K. Fluorescence lymph node mapping in living mice using
quantum dots and a compression technique. J Fluoresc. 2010;20:599-606
1064.
Inoue Y, Kiryu S, Watanabe M, Tojo A, Ohtomo K. Timing of imaging after d-luciferin injection affects the
longitudinal assessment of tumor growth using in vivo bioluminescence imaging. Int J Biomed Imaging.
2010;2010
1065.
Inoue Y, Masutani Y, Kiryu S, Haishi T, Watanabe M, Tojo A, Ohtomo K. Integrated imaging approach to tumor
model mice using bioluminescence imaging and magnetic resonance imaging. Mol Imaging. 2010;9:163-172
1066.
Inoue Y, Tojo A, Sekine R, Soda Y, Kobayashi S, Nomura A, Izawa K, Kitamura T, Okubo T, Ohtomo K. In vitro
validation of bioluminescent monitoring of disease progression and therapeutic response in leukaemia model
animals. Eur J Nucl Med Mol Imaging. 2006;33:557-565
1067.
Intra J, Salem AK. Characterization of the transgene expression generated by branched and linear
polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo. J Control
Release. 2008;130:129-138
1068.
Irvine RA, Adachi N, Shibata DK, Cassell GD, Yu K, Karanjawala ZE, Hsieh CL, Lieber MR. Generation and
characterization of endonuclease g null mice†
abstracts from the ninth annual meeting of the society for neuro-oncology: November 18–21, 2004. Molecular and
Cellular Biology. 2005;25:294-302
1069.
Isaacs J, Pili R, Qian D, Dalrymple S, Garrison J, Kyprianou N, Björk A, Olsson A, Leanderson T. Identification of
abr-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of
prostate cancer. Prostate. 2006;66:1768-1778
1070.
Isaksson EL, Aili M, Fahlgren A, Carlsson SE, Rosqvist R, Wolf-Watz H. The membrane localization domain is
required for intracellular localization and autoregulation of yope in yersinia pseudotuberculosis▿. Infection and
Immunity. 2009;77:4740-4749
1071.
Isaza MP, Chau JT, Le A, Balashova NV, Patel JK, Salerno E, Crosby JA, O'Connor A, Kachlany SC. A
bioluminescent hl-60 cell line to assay anti-leukaemia therapeutics under physiological conditions.
Luminescence. 2008;23:17-21
1072.
Ishii T, Asai T, Urakami T, Oku N. Accumulation of macromolecules in brain parenchyma in acute phase of
cerebral infarction/reperfusion. Brain Res. 2010;1321:164-168
1073.
Ishikawa T, Jain N, Herschman HR. Feedback regulation of cyclooxygenase-2 transcription ex vivo and in vivo.
Biochemical and Biophysical Research Communications. 2009;378:534-538
1074.
Ishikawa TO, Naveen KJ, Makoto MT, Harvey RH. Imaging cyclooxygenase-2 (cox-2) gene expression in living
animals with a luciferase knock-in reporter gene. Molecular Imaging and Biology. 2006;V8:171-187
1075.
Ishikawa TO, Oshima M, Herschman HR. Cox-2 deletion in myeloid and endothelial cells, but not in epithelial
cells, exacerbates murine colitis. Carcinogenesis. 2011;32:417-426
1076.
Israyelyan A, Melancon J, Lomax L, Sehgal I, Leuschner C, Kearney M, Chouljenko V, Baghian A, Kousoulas K.
Effective treatment of human breast tumor in a mouse xenograft model with herpes simplex virus type 1
specifying the nv1020 genomic deletion and the gbsyn3 syncytial mutation enabling high viral replication and
spread in breast cancer cells. Human Gene Therapy. 2007;18:457-473
1077.
Itaka K, Osada K, Morii K, Kim P, Yun SH, Kataoka K. Polyplex nanomicelle promotes hydrodynamic gene
introduction to skeletal muscle. J Control Release. 2010
1078.
Iwasaki J, Hata T, Hishikawa S, Fujimoto Y, Uemoto S, Murakami T, Kobayashi E. Use of rat segmental intestine
for fetal pancreatic transplantation. Microsurgery. 2010;30:296-301
1079.
1080.
1081.
1082.
1083.
1084.
1085.
1086.
1087.
1088.
1089.
1090.
1091.
1092.
1093.
1094.
1095.
1096.
1097.
1098.
1099.
1100.
1101.
1102.
1103.
Iyer M, Berenji M, Templeton NS, Gambhir SS. Noninvasive imaging of cationic lipid-mediated delivery of
optical and pet reporter genes in living mice. Molecular Therapy. 2002;6:555-562
Iyer M, Salazar FB, Lewis X, Zhang L, Wu L, Carey M, Gambhir SS. Non-invasive imaging of a transgenic mouse
model using a prostate-specific two-step transcriptional amplification strategy. Transgenic Res. 2005;14:47-55
Iyer M, Salazar FB, Wu L, Carey M, Gambhir SS. Bioluminescence imaging of systemic tumor targeting using a
prostate-specific lentiviral vector. Human Gene Therapy. 2006;17:125-132
Iyer M, Wu L, Carey M, Wang Y, Smallwood A, Gambhir SS. Two-step transcriptional amplification as a method
for imaging reporter gene expression using weak promoters. Proceedings of the National Academy of Sciences of
the United States of America. 2001;98:14595-14600
Izmailova ES, Paz N, Alencar H, Chun M, Schopf L, Hepperle M, Lane JH, Harriman G, Xu Y, Ocain T, Weissleder R,
Mahmood U, Healy AM, Jaffee B. Use of molecular imaging to quantify response to ikk-2 inhibitor treatment in
murine arthritis. Arthritis Rheum. 2007;56:117-128
Jaboin JI, Fu A, Hariri G, Han Z, Hallahan D. Novel radiation-guided nanoparticle drug delivery system for
prostate cancer. International Journal of Radiation Oncology Biology Physics. 2007;69:S111
Jaboin JJ, Han Z, Hallahan DE. Using in vivo biopanning for the development of radiation-guided drug delivery
systems. Methods Mol Biol. 2009;542:285-300
Jackson H, Muhammad O, Daneshvar H, Nelms J, Popescu A, Vogelbaum MA, Bruchez M, Toms SA. Quantum dots
are phagocytized by macrophages and colocalize with experimental gliomas. Neurosurgery. 2007;60:524-529;
discussion 529-530
Jacobson GB, Shinde R, Contag CH, Zare RN. Sustained release of drugs dispersed in polymer nanoparticles**.
Angewandte Chemie. International Ed. In English. 2008;47:7880-7882
Jagadeesh G, Prakash GD, Rakesh SG, Allam US, Krishna MG, Eswarappa SM, Chakravortty D. Needleless vaccine
delivery using micro-shock waves. Clinical and vaccine immunology : CVI. 2011;18:539-545
Jagu S, Karanam B, Gambhira R, Chivukula SV, Chaganti RJ, Lowy DR, Schiller JT, Roden RBS. Concatenated
multitype l2 fusion proteins as candidate prophylactic pan-human papillomavirus vaccines. Journal of the
National Cancer Institute. 2009;101:782-792
Jakubikova J, Adamia S, Kost-Alimova M, Klippel S, Cervi D, Daley JF, Cholujova D, Kong SY, Leiba M, Blotta S,
Ooi M, Delmore J, Laubach J, Richardson PG, Sedlak J, Anderson KC, Mitsiades CS. Lenalidomide targets
clonogenic side population in multiple myeloma: Pathophysiologic and clinical implications. Blood.
2011;117:4409-4419
Jang JH, Rives CB, Shea LD. Plasmid delivery in vivo from porous tissue-engineering scaffolds: Transgene
expression and cellular transfection. Mol Ther. 2005;12:475-483
Jang JH, Shea LD. Intramuscular delivery of DNA releasing microspheres: Microsphere properties and transgene
expression. J Control Release. 2006;112:120-128
Jang SW, Svaren J. Induction of myelin protein zero by early growth response 2 through upstream and intragenic
elements. J Biol Chem. 2009;284:20111-20120
Jarzyna PA, Skajaa T, Gianella A, Cormode DP, Samber DD, Dickson SD, Chen W, Griffioen AW, Fayad ZA, Mulder
WJ. Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and
imaging. Biomaterials. 2009;30:6947-6954
Jawad MU, Garamszegi N, Garamszegi SP, Correa-Medina M, Diez JA, Wen R, Scully SP. Matrix metalloproteinase
1: Role in sarcoma biology PLoS ONE. 2010
Jawhara S, Mordon S. Monitoring of bactericidal action of laser by in vivo imaging of bioluminescent e. Coli in a
cutaneous wound infection. Lasers in Medical Science. 2006;21:153-159
Jearawiriyapaisarn N, Moulton HM, Buckley B, Roberts J, Sazani P, Fucharoen S, Iversen PL, Kole R. Sustained
dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice. Mol
Ther. 2008;16:1624-1629
Jenkins D, Hornig Y, Oei Y, Yu S, Dusich J, Purchio T. Luciferase-expressing mcf-7-luc-f5 human breast cancer
cells used to monitor mammary fat pad tumor growth and metastasis in vivo in nude-beige mice. Proceedings of
the American Association for Cancer Research. 2004;2004:1179
Jenkins DE, Hornig YS, Oei Y, Dusich J, Purchio T. Bioluminescent human breast cancer cell lines that permit
rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice.
Breast Cancer Res. 2005;7:R444-454
Jenkins DE, Oei Y, Hornig YS, Yu SF, Dusich J, Purchio T, Contag PR. Bioluminescent imaging (bli) to improve
and refine traditional murine models of tumor growth and metastasis. Clinical and Experimental Metastasis.
2003;20:733-744
Jenkins DE, Redman RL, Lam EM, Liu C, Lin I, Arvin AM. Interleukin (il)-10, il-12, and interferon-(gamma)
production in primary and memory immune responses to varicella-zoster virus. Journal of Infectious Diseases.
1998;178:940-948
Jenkins DE, Yu SF, Hornig YS, Purchio T, Contag PR. In vivo monitoring of tumor relapse and metastasis using
bioluminescent pc-3m-luc-c6 cells in murine models of human prostate cancer. Clinical and Experimental
Metastasis. 2003;20:745-756
Jenq RR, King CG, Volk C, Suh D, Smith OM, Rao UK, Yim NL, Holland AM, Lu SX, Zakrzewski JL, Goldberg GL,
Diab A, Alpdogan O, Penack O, Na IK, Kappel LW, Wolchok JD, Houghton AN, Perales MA, van den Brink MR.
Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow
1104.
1105.
1106.
1107.
1108.
1109.
1110.
1111.
1112.
1113.
1114.
1115.
1116.
1117.
1118.
1119.
1120.
1121.
1122.
1123.
1124.
1125.
1126.
1127.
transplantation. Blood. 2009;113:1574-1580
Jensen M, Bruggen J, Dilea C, Mestan J, Manley P. Amn107: Efficacy of the selective bcr-abl tyrosine kinase
inhibitor in a murine model of chronic myelogenous leukemia. Proceedings of the American Association for
Cancer Research. 2006;2006:61
Jensen MR, Ide S, Brueggen J, Schoepfer J, Wang X, Quadt C, Garcia-Echeverria C. Pharmakokinctic/
phamacodynamic relationship of the hsp90 inhibitor nnt-auy922 in human xenografts and patients in a clinical
phase i trial. Proceedings of the American Association for Cancer Research Annual Meeting.
2009;50:1362-1363
Jeon BH, Jang C, Han J, Kataru RP, Piao L, Jung K, Cha HJ, Schwendener RA, Jang KY, Kim KS, Alitalo K, Koh GY.
Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from cd11b+
macrophages in advanced ovarian cancer. Cancer Res. 2008;68:1100-1109
Jeon Y, Choi Y, Kang J, Chung J, Lee Y, Kim C. In vivo monitoring of DNA vaccine gene expression using firefly
luciferase as a naked DNA. Vaccine. 2006;24:3057-3062
Jeon Y, Choi Y, Kim H, Kim C, Jeong J, Lee D, Chung J. Human sodium iodide symporter gene adjunctive
radiotherapy to enhance the preventive effect of hmuc1 DNA vaccine. International Journal of Cancer.
2007;121:1593-1599
Jeon YH, Choi Y, Kang JH, Kim CW, Jeong JM, Lee DS, Chung JK. Immune response to firefly luciferase as a
naked DNA. Cancer Biol Ther. 2007;6
Jeon YH, Choi Y, Kim HJ, Kang JH, Kim CW, Jeong JM, Lee DS, Chung JK. In vivo bioluminescence visualization
of antitumor effects by human muc1 vaccination. Mol Imaging. 2007;6:297-303
Jeon YH, Choi Y, Yoon SO, Kim CW, Chung JK. Synergistic tumoricidal effect of combined hmuc1 vaccination
and hnis radioiodine gene therapy. Mol Cancer Ther. 2008;7:2252-2260
Jia D, Koonce NA, Halakatti R, Li X, Yaccoby S, Swain FL, Suva LJ, Hennings L, Berridge MS, Apana SM, Mayo K,
Corry PM, Griffin RJ. Repression of multiple myeloma growth and preservation of bone with combined
radiotherapy and anti-angiogenic agent. Radiat Res. 2010;173:809-817
Jia Q, Freeman ML, Yager EJ, McHardy I, Tong L, Martinez-Guzman D, Rickabaugh T, Hwang S, Blackman MA,
Sun R, Wu TT. Induction of protective immunity against murine gammaherpesvirus 68 infection in the absence
of viral latency. J Virol. 2010;84:2453-2465
Jia W, Wang S, Horner JW, Wang N, Wang H, Gunther EJ, DePinho RA, Zhu J. A bac transgenic reporter
recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis.
Faseb J. 2011;25:979-989
Jia Y, Warin R, Yu X, Epstein R, Noguchi CT. Erythropoietin signaling promotes transplanted progenitor cell
survival. FASEB Journal. 2009;23:3089-3099
Jiang S, Kim H, Vu N, Tae S, Bom H, Choy H, Min J. Imaging breast cancer and its metastatic lesions using lightemitting bacteria. J Nucl Med. 2007;48:330P.
Jiang SN, Phan TX, Nam TK, Nguyen VH, Kim HS, Bom HS, Choy HE, Hong Y, Min JJ. Inhibition of tumor growth
and metastasis by a combination of escherichia coli-mediated cytolytic therapy and radiotherapy. Mol Ther.
2010;18:635-642
Jiang W, Couroucli XI, Wang L, Barrios R, Moorthy B. Augmented oxygen-mediated transcriptional activation of
cytochrome p450 (cyp)1a expression and increased susceptibilities to hyperoxic lung injury in transgenic mice
carrying the human cyp1a1 or mouse 1a2 promoter in vivo. Biochemical and biophysical research
communications. 2011;407:79-85
Jiang W, Wang L, Kondraganti SR, Fazili IS, Couroucli XI, Felix EA, Moorthy B. Disruption of the gene for
cyp1a2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse
cyp1a1 expression and augmented human cyp1a1 transcriptional activation in response to 3methylcholanthrene in vivo. The Journal of pharmacology and experimental therapeutics. 2010;335:369-379
Jiang W, Wang L, Zhang W, Coffee R, Fazili IS, Moorthy B. Persistent induction of cytochrome p450 (cyp)1a
enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the
corresponding promoters. Biochemical and Biophysical Research Communications. 2009;390:1419-1424
Jiang Z, Georgel P, Li C, Choe J, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath S, Wilson IA, Olson A,
Beutler B. Details of toll-like receptor:Adapter interaction revealed by germ-line mutagenesis. Proceedings of the
National Academy of Sciences of the United States of America. 2006;103:10961-10966
Jimenez AS, Gressette M, Barjon C, Wei M, Gourzones C, Busson P. Rapid obtention of stable, bioluminescent
tumor cell lines using a tcd2-luciferase chimeric construct. BMC biotechnology. 2011;11:26
Jin B, He K, Wang H, Bai B, Zhou T, Li H, Man J, Liu B, Gong W, Wang J. Proteomics analysis reveals insight into
the mechanism of h-ras-mediated transformation. J. Proteome Res. 2006;5:2815-2823
Jin Q, Anusaksathien O, Webb SA, Printz MA, Giannobile WV. Engineering of tooth-supporting structures by
delivery of pdgf gene therapy vectors. Mol Ther. 2004;9:519-526
Jing W, Gershan JA, Johnson BD. Depletion of cd4 t cells enhances immunotherapy for neuroblastoma after
syngeneic hsct but compromises development of antitumor immune memory. Blood. 2009;113:4449-4457
Jing W, Yan X, Hallett WH, Gershan JA, Johnson BD. Depletion of cd25 t cells from hematopoietic stem cell
grafts increases posttransplantation vaccine-induced immunity to neuroblastoma. Blood. 2011;117:6952-6962
Johansson G, Mahller YY, Collins MH, Kim MO, Nobukuni T, Perentesis J, Cripe TP, Lane HA, Kozma SC, Thomas
G, Ratner N. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral
1128.
1129.
1130.
1131.
1132.
1133.
1134.
1135.
1136.
1137.
1138.
1139.
1140.
1141.
1142.
1143.
1144.
1145.
1146.
1147.
1148.
1149.
1150.
nerve sheath tumors. Mol Cancer Ther. 2008;7:1237-1245
Johnson KM, Kines RC, Roberts JN, Lowy DR, Schiller JT, Day PM. Role of heparan sulfate in attachment to and
infection of the murine female genital tract by human papillomavirus. J Virol. 2009;83:2067-2074
Johnson M, Huyn S, Burton J, Sato M, Wu L. Differential biodistribution of adenoviral vector in vivo as
monitored by bioluminescence imaging and quantitative polymerase chain reaction. Hum Gene Ther. 2006
Johnson M, Sato M, Burton J, Gambhir SS, Carey M, Wu L. Micro-pet/ct monitoring of herpes thymidine kinase
suicide gene therapy in a prostate cancer xenograft: The advantage of a cell-specific transcriptional targeting
approach. Mol Imaging. 2005;4:463-472
Johnstone CN, Mongroo PS, Rich AS, Schupp M, Bowser MJ, Delemos AS, Tobias JW, Liu Y, Hannigan GE,
Rustgi AK. Parvin-beta inhibits breast cancer tumorigenicity and promotes cdk9-mediated peroxisome
proliferator-activated receptor gamma 1 phosphorylation. Mol Cell Biol. 2008;28:687-704
Jokinen J, Nykänen A, Pajusola K, Tuuminen R, Krebs R, Soronen J, Alitalo K, Lemström K. Efficient and longlasting adeno-associated virus 8 (aav8) vector-mediated transgene expression in heart transplant myocardium:
549. Transplantation. 2008;86:192
Jones EF, Schooler J, Miller DC, Drake CR, Wahnishe H, Siddiqui S, Li X, Majumdar S. Characterization of human
osteoarthritic cartilage using optical and magnetic resonance imaging. Molecular imaging and biology : MIB :
the official publication of the Academy of Molecular Imaging. 2011
Jones L, Goun E, Shinde R, Rothbard J, Contag C, Wender P. Releasable luciferin-transporter conjugates: Tools
for the real-time analysis of cellular uptake and release. J. Am. Chem. Soc. 2006;128:6526-6527.
Joo SY, Cho KA, Jung YJ, Kim HS, Park SY, Choi YB, Hong KM, Woo SY, Seoh JY, Ryu KH. Bioimaging to
monitor the in vivo distribution of infused mesenchymal stem cells: In a mouse model of graft versus host
disease. Cell Biology International. 2010
Joo SY, Cho KA, Jung YJ, Kim HS, Park SY, Choi YB, Hong KM, Woo SY, Seoh JY, Ryu KH. Bioimaging for the
monitoring of the in vivo distribution of infused mesenchymal stem cells in a mouse model of the graft-versushost reaction. Cell biology international. 2011;35:417-421
Joseph A, Li Y, Koo HC, Davis JM, Pollack S, Kazzaz JA. Superoxide dismutase attenuates hyperoxia-induced
interleukin-8 induction via ap-1. Free Radic Biol Med. 2008;45:1143-1149
Jung HS, Erkin OC, Kwon MJ, Kim SH, Jung JI, Oh YK, Her SW, Ju W, Choi YL, Song SY, Kim JK, Kim YD, Shim
GY, Shin YK. The synergistic therapeutic effect of cisplatin with human papillomavirus e6/e7 short interfering
rna on cervical cancer cell lines in vitro and in vivo. International journal of cancer. Journal international du
cancer. 2011
Jung K, Lee JE, Kim HZ, Kim HM, Park BS, Hwang SI, Lee JO, Kim SC, Koh GY. Toll-like receptor 4 decoy, toy,
attenuates gram-negative bacterial sepsis. PLoS One. 2009;4
Jurcisek JA, Bookwalter JE, Baker BD, Fernandez S, Novotny LA, Munson RS, Jr., Bakaletz LO. The pila protein of
non-typeable haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and
colonization of the mammalian upper respiratory tract. Mol Microbiol. 2007;65:1288-1299
Kadioglu A, Brewin H, Hartel T, Brittan JL, Klein M, Hammerschmidt S, Jenkinson HF. Pneumococcal protein
pava is important for nasopharyngeal carriage and development of sepsis. Mol Oral Microbiol. 2010;25:50-60
Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James
CD, Rubenstein JL. Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic
xenograft model. Clin Cancer Res. 2009;15:1989-1997
Kadurugamuwa JL, Francis KP. Bioluminescent imaging of bacterial biofilm infections in vivo. Methods Mol
Biol. 2008;431:225-239
Kadurugamuwa JL, Kimura R, Yu J, Francis K, Orihuela C, Tuomanen E, Purchio AF, Contag PR. Non-invasive
method for monitoring drug efficacy in the treatment of bacterial meningitis in an experimental murine model.
Abstracts of the General Meeting of the American Society for Microbiology. 2003;103:D-170
Kadurugamuwa JL, Modi K, Coquoz O, Rice B, Smith S, Contag PR, Purchio T. Reduction of astrogliosis by early
treatment of pneumococcal meningitis measured by simultaneous imaging, in vivo, of the pathogen and host
response. Infection and Immunity. 2005;73:7836-7843
Kadurugamuwa JL, Modi K, Yu J, Francis KP, Orihuela C, Tuomanen E, Purchio AF, Contag PR. Noninvasive
monitoring of pneumococcal meningitis and evaluation of treatment efficacy in an experimental mouse model.
Mol Imaging. 2005;4:137-142
Kadurugamuwa JL, Modi K, Yu J, Francis KP, Purchio T, Contag PR. Noninvasive biophotonic imaging for
monitoring of catheter-associated urinary tract infections and therapy in mice. Infection and Immunity.
2005;73:3878-3887
Kadurugamuwa JL, Sin L, Albert E, Winterberg P, Larkin A, Bellinger-Kawahara C, DeBoer M, Yu J, Rubin M,
Francis K, Parr T. A direct continuous method to monitor biofilms on medical devices. Abstracts of the General
Meeting of the American Society for Microbiology. 2002;102:266
Kadurugamuwa JL, Sin L, Albert E, Yu J, Francis K, DeBoer M, Rubin M, Bellinger-Kawahara C, Parr Jr TR, Jr.,
Contag PR. Direct continuous method for monitoring biofilm infection in a mouse model. Infection and
Immunity. 2003;71:882-890
Kadurugamuwa JL, Sin L, Zhang N, Doyle T, Contag PR, Purchio AF. In vivo biophotonic monitoring of serum
amyloid a response to bacterial challenge in mice. Abstracts of the General Meeting of the American Society for
Microbiology. 2003;103:E-037
1151.
1152.
1153.
1154.
1155.
1156.
1157.
1158.
1159.
1160.
1161.
1162.
1163.
1164.
1165.
1166.
1167.
1168.
1169.
1170.
1171.
1172.
1173.
1174.
1175.
Kadurugamuwa JL, Sin LV, Yu J, Francis KP, Kimura R, Purchio T, Contag PR. Rapid direct method for
monitoring antibiotics in a mouse model of bacterial biofilm infection. Antimicrobial Agents and
Chemotherapy. 2003;47:3130-3137
Kahlon K, Brown C, Cooper L, Raubitschek A, Forman S, Jensen M. Specific recognition and killing of
glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic t cells. Cancer Res. 2004;64:9160
Kaijzel EL, Snoeks TJ, Buijs JT, van der Pluijm G, Lowik CW. Multimodal imaging and treatment of bone
metastasis. Clin Exp Metastasis. 2008
Kaijzel EL, van der Pluijm G, Lowik CW. Whole-body optical imaging in animal models to assess cancer
development and progression. Clin Cancer Res. 2007;13:3490-3497
Kakinuma T, Hwang ST. Chemokines, chemokine receptors, and cancer metastasis. J Leukoc Biol.
2006;79:639-651
Kakinuma T, Nadiminti H, Lonsdorf A, Murakami T, Perez B, Kobayashi H, Finkelstein S, Pothiawala G, Belkaid Y,
Hwang S. Small numbers of residual tumor cells at the site of primary inoculation are critical for anti-tumor
i mmu n i t y fo l l o wi n g ch al l en g e at a s eco n d ary l o cat i o n . Ca n cer Immu n o l o g y, Immu n o t h er a p y.
2007;56:1119-1131
Kalchenko V, Shivtiel S, Malina V, Lapid K, Haramati S, Lapidot T, Brill A, Harmelin A. Use of lipophilic nearinfrared dye in whole-body optical imaging of hematopoietic cell homing. J Biomed Opt. 2006;11:050507
Kalra J, Warburton C, Fang K, Edwards L, Daynard T, Waterhouse D, Dragowska W, Sutherland BW, Dedhar S,
Gelmon K, Bally M. Qlt0267, a small molecule inhibitor targeting integrin-linked kinase (ilk), and docetaxel can
combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in p-akt levels, altered
f-actin architecture and improved treatment outcomes in an orthotopic breast cancer model. Breast Cancer Res.
2009;11:R25
Kamath V, Goldgof D, Argilagos R, Hazlehurst L, Eschrich S. Towards a framework for analysis of biophotonic
images of mouse models of cancer. Conf Proc IEEE Eng Med Biol Soc. 2008:3079-3082
Kamei K, Ishikawa T, Herschman H. Transgenic mouse for conditional, tissue-specific cox-2 overexpression.
Genesis. 2006;44:177-182
Kammili RK, Taylor DG, Xia J, Osuala K, Thompson K, Menick DR, Ebert SN. Generation of novel reporter stem
cells and their application for molecular imaging of cardiac-differentiated stem cells in vivo. Stem Cells Dev.
2010;19:1437-1448
Kanazawa H, Fujimoto Y, Teratani T, Iwasaki J, Kasahara N, Negishi K, Tsuruyama T, Uemoto S, Kobayashi E. Bone
marrow-derived mesenchymal stem cells ameliorate hepatic ischemia reperfusion injury in a rat model. PloS one.
2011;6:e19195
Kanerva A, Zinn KR, Chaudhuri TR, Lam JT, Suzuki K, Uil TG, Hakkarainen T, Bauerschmitz GJ, Wang M, Liu B,
Cao Z, Alvarez RD, Curiel DT, Hemminki A. Enhanced therapeutic efficacy for ovarian cancer with a serotype 3
receptor-targeted oncolytic adenovirus. Molecular Therapy. 2003;8:449-458
Kanerva A, Zinn KR, Peng KW, Ranki T, Kangasniemi L, Chaudhuri TR, Desmond RA, Wang M, Takayama K,
Hakkarainen T, Alfthan H, Stenman UH, Curiel DT, Hemminki A. Noninvasive dual modality in vivo monitoring
of the persistence and potency of a tumor targeted conditionally replicating adenovirus. Gene Ther.
2005;12:87-94
Kang CI, Rouse MS, Patel R, Kita H, Juhn YJ. Allergic airway inflammation and susceptibility to pneumococcal
pneumonia in a murine model with real-time in vivo evaluation. Clinical and Experimental Immunology.
2009;156:552-561
Kang HW, Walvick R, Bogdanov A, Jr. In vitro and in vivo imaging of antivasculogenesis induced by noggin
protein expression in human venous endothelial cells. Faseb J. 2009;23:4126-4134
Kang IJ, Wang LW, Hsu SJ, Lee CC, Lee YC, Wu YS, Hsu TA, Yueh A, Chao YS, Chern JH. Design and synthesis of
indole, 2,3-dihydro-indole, and 3,4-dihydro-2h-quinoline-1-carbothioic acid amide derivatives as novel hcv
inhibitors. Bioorg Med Chem Lett. 2009
Kang SH, Cho HT, Devi S, Zhang Z, Escuin D, Liang Z, Mao H, Brat DJ, Olson JJ, Simons JW, Lavallee TM,
Giannakakou P, Van Meir EG, Shim H. Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor
model. Cancer Res. 2006;66:11991-11997
Kang TH, Chung JY, Monie A, Pai SI, Hung CF, Wu T. Enhancing DNA vaccine potency by co-administration of
xenogenic mhc-class-i DNA. Gene Therapy. 2010;17:531-540
Kang Y. Analysis of cancer stem cell metastasis in xenograft animal models. Cancer stem cells. 2008:7-19.
Kang Y. Analysis of cancer stem cell metastasis in xenograft animal models. Methods Mol Biol. 2009;568:7-19
Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen CR, Manova-Todorova K, Blasberg R, Gerald WL, Massagué
J. Breast cancer bone metastasis mediated by the smad tumor suppressor pathway. Proceedings of the National
Academy of Sciences of the United States of America. 2005;102:13909-13914
Kanno A, Ozawa T, Umezawa Y. Genetically encoded optical probe for detecting release of proteins from
mitochondria toward cytosol in living cells and mammals. Anal Chem. 2006;78:8076-8081
Kanno A, Umezawa Y, Ozawa T. Detection of apoptosis using cyclic luciferase in living mammals.
Bioluminescence. 2009:105-114.
Kano A, Moriyama K, Yamano T, Nakamura I, Shimada N, Maruyama A. Grafting of poly(ethylene glycol) to polylysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to
associate with sirna. J Control Release. 2009
1176.
1177.
1178.
1179.
1180.
1181.
1182.
1183.
1184.
1185.
1186.
1187.
1188.
1189.
1190.
1191.
1192.
1193.
1194.
1195.
1196.
1197.
1198.
1199.
1200.
1201.
Kapoor R, Eimerman PR, Hardy JW, Cirillo JD, Contag CH, Barron AE. Efficacy of antimicrobial peptoids against
mycobacterium tuberculosis. Antimicrobial agents and chemotherapy. 2011;55:3058-3062
Karanam B, Gambhira R, Peng S, Jagu S, Kim DJ, Ketner GW, Stern PL, Adams RJ, Roden RB. Vaccination with
hpv16 l2e6e7 fusion protein in gpi-0100 adjuvant elicits protective humoral and cell-mediated immunity.
Vaccine. 2009;27:1040-1049
Karanikolas BD, Figueiredo ML, Wu L. Polycomb group protein enhancer of zeste 2 is an oncogene that promotes
the neoplastic transformation of a benign prostatic epithelial cell line. Mol Cancer Res. 2009;7:1456-1465
Kargiotis O, Chetty C, Gondi CS, Tsung AJ, Dinh DH, Gujrati M, Lakka SS, Kyritsis AP, Rao JS. Adenovirusmediated transfer of sirna against mmp-2 mrna results in impaired invasion and tumor-induced angiogenesis,
induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma. Oncogene. 2008;27:4830-4840
Karimi M, Cao T, Baker J, Verneris M, Soares L, Negrin R. Silencing human nkg2d, dap10, and dap12 reduces
cytotoxicity of activated cd8+ t cells and nk cells. The Journal of Immunology. 2005;175:7819
Karlsen A, Retterstol L, Laake P, Paur I, Kjolsrud-Bohn S, Sandvik L, Blomhoff R. Anthocyanins inhibit nuclear
factor-kappab activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in
healthy adults. J Nutr. 2007;137:1951-1954
Karlström Å, Boyd KL, English BK, McCullers JA. Treatment with protein synthesis inhibitors improves
outcomes from secondary bacterial pneumonia following influenza. Journal of Infectious Diseases.
2009;199:311-319
Karmakar S, Choudhury SR, Banik NL, Ray SK. Activation of multiple molecular mechanisms for increasing
apoptosis in human glioblastoma t98g xenograft. Journal of cancer science & therapy. 2010;2:107-113
Karsi A, Gülsoy N, Corb E, Dumpala PR, Lawrence ML. High-throughput bioluminescence-based mutant
screening strategy for identification of bacterial virulence genes▿. Applied and Environmental Microbiology.
2009;75:2166-2175
Karsi A, Howe K, Kirkpatrick TB, Wills R, Bailey RH, Lawrence ML. Development of bioluminescent salmonella
strains for use in food safety. BMC Microbiol. 2008;8:10
Karsi A, Lawrence ML. Broad host range fluorescence and bioluminescence expression vectors for gram-negative
bacteria. Plasmid. 2007;57:286-295
Karsi A, Menanteau Ledouble S, Lawrence M. Development of bioluminescent edwardsiella ictaluri for
noninvasive disease monitoring. FEMS Microbiology Letters. 2006;260:216-223
Kassovska-Bratinova S, Yang G, Igarashi K, Dennery PA. Bach1 modulates heme oxygenase-1 expression in the
neonatal mouse lung. Pediatric Research. 2009;65:145-149
Kataru RP, Jung K, Jang C, Yang H, Schwendener RA, Baik JE, Han SH, Alitalo K, Koh GY. Critical role of cd11b+
macrophages and vegf in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.
Blood. 2009
Kato A, Minami K, Ito H, Tomii T, Matsumoto M, Orita S, Kihara T, Narita M, Suzuki T. Oxycodone-induced
analgesic effects in a bone cancer pain model in mice. Oncology. 2008;74 Suppl 1:55-60
Kato Y, Yoshimura K, Shin T, Verheul H, Hammers H, Sanni T, Salumbides B, Van Erp K, Schulick R, Pili R.
Synergistic in vivo antitumor effect of the histone deacetylase inhibitor ms-275 in combination with interleukin
2 in a murine model of renal cell carcinoma. Clinical Cancer Research. 2007;13:4538
Kauskot A, Manent J, Chareyre F, Cominetti M, Chopin M, Giovannini M, Legrand C, Bonnefoy A.
[bioluminescent imaging to monitor tumor progression and metastasis in live animal.]. J Soc Biol.
2007;201:223-228
Kawata E, Ashihara E, Kimura S, Takenaka K, Sato K, Tanaka R, Yokota A, Kamitsuji Y, Takeuchi M, Kuroda J,
Tanaka F, Yoshikawa T, Maekawa T. Administration of plk-1 small interfering rna with atelocollagen prevents the
growth of liver metastases of lung cancer. Mol Cancer Ther. 2008;7:2904-2912
Kazmierczak KM, Wayne KJ, Rechtsteiner A, Winkler ME. Roles of relspn in stringent response, global
regulation, and virulence of serotype 2 streptococcus pneumoniae d39. Molecular Microbiology.
2009;72:590-611
Ke B, Kaldas F, Meng L, Busuttil R, Kupiec-Weglinski J, Farmer D. The intestinal injury induced by ischemia and
reperfusion triggers activation of innate tlr4 and multiple chemokine and adhesion molecule programs.
Transplantation. 2006;82:366
Keller AF, Gravel M, Kriz J. Live imaging of amyotrophic lateral sclerosis pathogenesis: Disease onset is
characterized by marked induction of gfap in schwann cells. Glia. 2009;57:1130-1142
Keller SA, Hernandez-Hopkins D, Vider J, Ponomarev V, Hyjek E, Schattner EJ, Cesarman E. Nf-kappab is essential
for the progression of kshv- and ebv-infected lymphomas in vivo. Blood. 2006;107:3295-3302
Kelly EJ, Nace R, Barber GN, Russell SJ. Attenuation of vesicular stomatitis virus encephalitis through microrna
targeting. J Virol. 2010;84:1550-1562
Kelly KJ, Brader P, Woo Y, Li S, Chen N, Yu YA, Szalay AA, Fong Y. Real-time intraoperative detection of
melanoma lymph node metastases using recombinant vaccinia virus glv-1h68 in an immunocompetent animal
model. International Journal of Cancer. 2009;124:911-918
Kelly P, Moeller BJ, Juneja J, Booden MA, Der CJ, Daaka Y, Dewhirst MW, Fields TA, Casey PJ. The g12 family of
heterotrimeric g proteins promotes breast cancer invasion and metastasis. Proceedings of the National Academy
of Sciences of the United States of America. 2006;103:8173-8178
Kelm C, Adams J, Buhr J, Henneking K, Schwemmle K. 'Combi-effect' after xenogen discordant heart-lung
1202.
1203.
1204.
1205.
1206.
1207.
1208.
1209.
1210.
1211.
1212.
1213.
1214.
1215.
1216.
1217.
1218.
1219.
1220.
1221.
1222.
1223.
1224.
t ran s p l an t at i o n . Tr a n s p l a n t a t i o n s med i z i n : Or g a n d er Deu t s ch en Tr a n s p l a n t a t i o n s g es el l s ch a f t .
1998;10:157-162
Kelm C, Adams J, Buhr J, Niemann F, Henneking K. Specificity of "combi-effect" after xenogenic discordant
heart-lung transplantation. Langenbecks Archiv f?r Chirurgie. Supplement. Kongressband. Deutsche
Gesellschaft f?r Chirurgie. Kongress. 1998;115:73-77
Kemper EM, Leenders W, Kusters B, Lyons S, Buckle T, Heerschap A, Boogerd W, Beijnen JH, van Tellingen O.
Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies. European
Journal of Cancer. 2006;42:3294-3303
Kennedy LC, Bear AS, Young JK, Lewinski NA, Kim J, Foster AE, Drezek RA. T cells enhance gold nanoparticle
delivery to tumors in vivo. Nanoscale research letters. 2011;6:283
Kepe V, Cole GM, Liu J, Flood DG, Trusko SP, Satyamurthy N, Huang SC, Small GW, Petric A, Phelps ME, Barrio
JR. Visualization of beta-amyloid deposits in the living brain of a triple transgenic rat model of beta-amyloid
deposition using f-18 fddnp-micropet imaging. Journal of Labelled Compounds and Radiopharmaceuticals.
2005;48:S43
Keppler OT, Welte FJ, Ngo TA, Chin PS, Patton KS, Tsou CL, Abbey NW, Sharkey ME, Grant RM, You Y,
Scarborough JD, Ellmeier W, Littman DR, Stevenson M, Charo IF, Herndier BG, Speck RF, Goldsmith MA.
Progress toward a human cd4/ccr5 transgenic rat model for de novo infection by human immunodeficiency virus
type 1. Journal of Experimental Medicine. 2002;195:719-736
Keravala A, Ormerod BK, Palmer TD, Calos MP. Long-term transgene expression in mouse neural progenitor cells
modified with phic31 integrase. Journal of Neuroscience Methods. 2008;173:299-305
Keren S, Gheysens O, Levin CS, Gambhir SS. A comparison between a time domain and continuous wave small
animal optical imaging system. IEEE Transactions on Medical Imaging. 2008;27:58-63
Keren S, Zavaleta C, Cheng Z, de la Zerda A, Gheysens O, Gambhir SS. Noninvasive molecular imaging of small
living subjects using raman spectroscopy. Proceedings of the National Academy of Sciences of the United States
of America. 2008;105:5844-5849
Kesarwala AH, Prior JL, Sun J, Harpstrite SE, Sharma V, Piwnica-Worms D. Second-generation triple reporter for
bioluminescence, micro-positron emission tomography, and fluorescence imaging. Mol Imaging.
2006;5:465-474
Kesisoglou F, Chamberlain J, Schmiedlin-Ren P, Kaz A, Fleisher D, Roessler B, Zimmermann E. Chimeric ad5
vectors expressing the short fiber of ad41 show reduced affinity for human intestinal epithelium. Mol. Pharm.
2005;2:500-508
Kesisoglou F, Schmiedlin-Ren P, Fleisher D, Roessler B, Zimmermann E. Restituting intestinal epithelial cells
exhibit increased transducibility by adenoviral vectors. The Journal of Gene Medicine. 2006;8:1379-1392
Keyaerts M, Verschueren J, Bos TJ, Tchouate-Gainkam LO, Peleman C, Breckpot K, Vanhove C, Caveliers V,
Bossuyt A, Lahoutte T. Dynamic bioluminescence imaging for quantitative tumour burden assessment using iv
or ip administration of d: -luciferin: Effect on intensity, time kinetics and repeatability of photon emission.
European journal of nuclear medicine and molecular imaging. 2008;35:999-1007
Keystone C. 3rd annual symposium of the american heart association council on basic cardiovascular sciences:
Translation of basic insights into clinical practice: July 31-august 3, 2006 keystone conference center keystone,
co: Bcvs symposium abstracts. Circulation Research. 2006;99:E18
Kfutwah AK, Mary JY, Nicola MA, Blaise-Boisseau S, Barré-Sinoussi F, Ayouba A, Menu E. Tumour necrosis
factor-α stimulates hiv-1 replication in single-cycle infection of human term placental villi fragments in a time,
viral dose and envelope dependent manner. Retrovirology. 2006;3:36
Khanbolooki S, Nawrocki ST, Arumugam T, Andtbacka R, Pino MS, Kurzrock R, Logsdon CD, Abbruzzese JL,
McConkey DJ. Nuclear factor-kappab maintains trail resistance in human pancreatic cancer cells. Mol Cancer
Ther. 2006;5:2251-2260
Khanna D, Hamilton CA, Bhojani MS, Lee KC, Dlugosz A, Ross BD, Rehemtulla A. A transgenic mouse for
imaging caspase-dependent apoptosis within the skin. J Invest Dermatol. 2010;130:1797-1806
Kheirolomoom A, Kruse DE, Qin S, Watson KE, Lai CY, Young LJ, Cardiff RD, Ferrara KW. Enhanced in vivo
bioluminescence imaging using liposomal luciferin delivery system. J Control Release. 2009
Khotskaya YB, Dai Y, Ritchie JP, MacLeod V, Yang Y, Zinn K, Sanderson RD. Syndecan-1 is required for robust
growth, vascularization, and metastasis of myeloma tumors in vivo. J Biol Chem. 2009;284:26085-26095
Kidd S, Caldwell L, Dietrich M, Samudio I, Spaeth EL, Watson K, Shi Y, Abbruzzese J, Konopleva M, Andreeff M,
Marini FC. Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an
effect countered by anti-inflammatory treatment. Cytotherapy. 2010
Kidd S, Spaeth E, Dembinski JL, Dietrich M, Watson K, Klopp A, Battula L, Weil M, Andreeff M, Marini FC. Direct
evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo
bioluminescence imaging. Stem Cells. 2009
Kielland A, Blom T, Nandakumar KS, Holmdahl R, Blomhoff R, Carlsen H. In vivo imaging of reactive oxygen
and nitrogen species in inflammation using the luminescent probe l-012. Free Radic Biol Med. 2009;47:760-766
Kielland A, Carlsen H. Molecular imaging of transcriptional regulation during inflammation. Journal of
inflammation. 2010;7:20
Kievit FM, Veiseh O, Bhattarai N, Fang C, Gunn JW, Lee D, Ellenbogen RG, Olson JM, Zhang M. Pei-peg-chitosan
copolymer coated iron oxide nanoparticles for safe gene delivery: Synthesis, complexation, and transfection**.
1225.
1226.
1227.
1228.
1229.
1230.
1231.
1232.
1233.
1234.
1235.
1236.
1237.
1238.
1239.
1240.
1241.
1242.
1243.
1244.
1245.
1246.
1247.
1248.
1249.
Adv Funct Mater. 2009;19:2244-2251
Kievit FM, Veiseh O, Fang C, Bhattarai N, Lee D, Ellenbogen RG, Zhang M. Chlorotoxin labeled magnetic
nanovectors for targeted gene delivery to glioma. ACS Nano. 2010;4:4587-4594
Kim D, Hoory T, Monie A, Wu A, Hsueh WT, Pai SI, Hung CF. Delivery of chemotherapeutic agents using drugloaded irradiated tumor cells to treat murine ovarian tumors. Journal of Biomedical Science. 2010;17:61
Kim D, Hung CF, Wu TC. Monitoring the trafficking of adoptively transferred antigen- specific cd8-positive t
cells in vivo, using noninvasive luminescence imaging. Hum Gene Ther. 2007;18:575-588
Kim D, Monie A, He L, Tsai YC, Hung CF, Wu TC. Role of il-2 secreted by padre-specific cd4+ t cells in enhancing
e7-specific cd8+ t-cell immune responses. Gene Ther. 2008;15:677-687
Kim DH, Choe YS, Choi JY, Lee KH, Kim BT. Binding of 2-[18f]fluoro-cp-118,954 to mouse acetylcholinesterase:
Micropet and ex vivo cerenkov luminescence imaging studies. Nuclear medicine and biology. 2011;38:541-547
Kim DW, Huamani J, Fu A, Hallahan DE. Molecular strategies targeting the host component of cancer to enhance
tumor response to radiation therapy. Int J Radiat Oncol Biol Phys. 2006;64:38-46
Kim EM, Park EH, Cheong SJ, Lee CM, Jeong HJ, Kim DW, Lim ST, Sohn MH. In vivo imaging of mesenchymalepithelial transition factor (c-met) expression using an optical imaging system. Bioconjug Chem.
2009;20:1299-1306
Kim H, Chaudhuri T, Buchsbaum D, Wang D, Zinn K. High-resolution single-photon emission computed
tomography and x-ray computed tomography imaging of tc-99m–labeled anti-dr5 antibody in breast tumor
xenografts. Mol Cancer Ther. 2007;6:866
Kim H, Morgan DE, Buchsbaum DJ, Zeng H, Grizzle WE, Warram JM, Stockard CR, McNally LR, Long JW, Sellers
JC, Forero A, Zinn KR. Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in
orthotopic pancreatic tumor xenografts by diffusion-weighted magnetic resonance imaging. Cancer Res.
2008;68:8369-8376
Kim H, Morgan DE, Zeng H, Grizzle WE, Warram JM, Stockard CR, Wang D, Zinn KR. Breast tumor xenografts:
Diffusion-weighted mr imaging to assess early therapy with novel apoptosis-inducing anti-dr5 antibody.
Radiology. 2008;248:844-851
Kim HJ, Chung JK, Hwang DW, Lee DS, Kim S. In vivo imaging of mir-221 biogenesis in papillary thyroid
carcinoma. Mol Imaging Biol. 2008
Kim HY, Kim S, Youn H, Chung JK, Shin DH, Lee K. The cell penetrating ability of the proapoptotic peptide,
klaklakklaklak fused to the n-terminal protein transduction domain of translationally controlled tumor protein,
miiyrdlish. Biomaterials. 2011;32:5262-5268
Kim HY, Verlander JW, Bishop JM, Cain BD, Han KH, Igarashi P, Lee HW, Handlogten ME, Weiner ID. Basolateral
expression of the ammonia transporter family member rh c glycoprotein in the mouse kidney. Am J Physiol Renal
Physiol. 2009;296:F543-555
Kim JB, Urban K, Cochran E, Lee S, Ang A, Rice B, Bata A, Campbell K, Coffee R, Gorodinsky A, Lu Z, Zhou H,
Kishimoto TK, Lassota P. Non-invasive detection of a small number of bioluminescent cancer cells in vivo. PLoS
One. 2010;5:e9364
Kim JH, Kim B, Cai L, Choi HJ, Ohgi KA, Tran C, Chen C, Chung CH, Huber O, Rose DW, Sawyers CL, Rosenfeld
MG, Baek SH. Transcriptional regulation of a metastasis suppressor gene by tip60 and [beta]-catenin complexes.
Nature. 2005;434:921-926
Kim JY, Choi WI, Kim YH, Tae G. Highly selective in-vivo imaging of tumor as an inflammation site by ros
detection using hydrocyanine-conjugated, functional nano-carriers. Journal of controlled release : official
journal of the Controlled Release Society. 2011
Kim KL, Han DK, Park K, Song SH, Kim JY, Kim JM, Ki HY, Yie SW, Roh CR, Jeon ES, Kim DK, Suh W. Enhanced
dermal wound neovascularization by targeted delivery of endothelial progenitor cells using an rgd-g-plla
scaffold. Biomaterials. 2009;30:3742-3748
Kim MH, Curry FRE, Simon SI. Dynamics of neutrophil extravasation and vascular permeability are uncoupled
during aseptic cutaneous wounding. Am J Physiol Cell Physiol. 2009;296:C848-856
Kim MH, Granick JL, Kwok C, Walker NJ, Borjesson DL, Curry FR, Miller LS, Simon SI. Neutrophil survival and
c-kit(+)-progenitor proliferation in staphylococcus aureus-infected skin wounds promote resolution. Blood.
2011;117:3343-3352
Kim MH, Liu W, Borjesson DL, Curry FRE, Miller LS, Cheung AL, Liu FT, Isseroff RR, Simon SI. Dynamics of
neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging. Journal of
Investigative Dermatology. 2008;128:1812-1820
Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L, Massague J. Tumor self-seeding by
circulating cancer cells. Cell. 2009;139:1315-1326
Kim RJ, Nam JS. Oct4 expression enhances features of cancer stem cells in a mouse model of breast cancer. Lab
Anim Res. 2011;27:147-152
Kim S, Ozawa T, Umezawa Y. Genetically encoded stress indicator for noninvasively imaging endogenous
corticosterone in living mice. Anal. Chem. 2005;77:6588-6593
Kim SA, Kim YC, Kim SW, Lee SH, Min JJ, Ahn SG, Yoon JH. Antitumor activity of novel indirubin derivatives in
rat tumor model. Clin Cancer Res. 2007;13:253-259
Kim SA, Sung YK, Kwon BM, Yoon JH, Lee H, Ahn SG, Hong SH. 2'-hydroxycinnamaldehyde shows antitumor
activity against oral cancer in vitro and in vivo in a rat tumor model. Anticancer Res. 2010;30:489-494
1250.
1251.
1252.
1253.
1254.
1255.
1256.
1257.
1258.
1259.
1260.
1261.
1262.
1263.
1264.
1265.
1266.
1267.
1268.
1269.
1270.
1271.
1272.
1273.
1274.
Kim SB, Ozawa T, Watanabe S, Umezawa Y. High-throughput sensing and noninvasive imaging of protein nuclear
transport by using reconstitution of split renilla luciferase. Proceedings of the National Academy of Sciences of
the United States of America. 2004;101:11542-11547
Kim SH, Nakagawa H, Navaraj A, Naomoto Y, Klein-Szanto AJ, Rustgi AK, El-Deiry WS. Tumorigenic conversion
of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous ras.
Cancer Res. 2006;66:10415-10424
Kim SI, Shin D, Choi TH, Lee JC, Cheon GJ, Kim KY, Park M, Kim M. Systemic and specific delivery of small
interfering rnas to the liver mediated by apolipoprotein a-i. Mol Ther. 2007;15:1145-1152
Kim SI, Shin D, Lee H, Ahn BY, Yoon Y, Kim M. Targeted delivery of sirna against hepatitis c virus by
apolipoprotein a-i-bound cationic liposomes. J Hepatol. 2009;50:479-488
Kim SK, Karasov A, Boothroyd JC. Bradyzoite-specific surface antigen srs9 plays a role in maintaining
toxoplasma gondii persistence in the brain and in host control of parasite replication in the intestine. Infect
Immun. 2007;75:1626-1634
Kim SY, Lee CH, Midura BV, Yeung C, Mendoza A, Hong SH, Ren L, Wong D, Korz W, Merzouk A, Salari H, Zhang
H, Hwang ST, Khanna C, Helman LJ. Inhibition of the cxcr4/cxcl12 chemokine pathway reduces the development
of murine pulmonary metastases. Clinical and Experimental Metastasis. 2008;25:201-211
Kim WI, Wiesner SM, Largaespada DA. Vav promoter-tta conditional transgene expression system for
hematopoietic cells drives high level expression in developing b and t cells. Exp Hematol. 2007;35:1231-1239
Kim YJ, Dubey P, Ray P, Gambhir SS, Witte ON. Multimodality imaging of lymphocytic migration using
lentiviral-based transduction of a tri-fusion reporter gene. Molecular Imaging and Biology. 2004;6:331-340
Kimbrel EA, Davis TN, Bradner JE, Kung AL. In vivo pharmacodynamic imaging of proteasome inhibition. Mol
Imaging. 2009;8:140-147
Kimura H, Ng JM, Curran T. Transient inhibition of the hedgehog pathway in young mice causes permanent
defects in bone structure. Cancer Cell. 2008;13:249-260
Kimura RH, Cheng Z, Gambhir SS, Cochran JR. Engineered knottin peptides: A new class of agents for imaging
integrin expression in living subjects. Cancer Res. 2009;69:2435-2442
Kimura RH, Miao Z, Cheng Z, Gambhir SS, Cochran JR. A dual-labeled knottin peptide for pet and near-infrared
fluorescence imaging of integrin expression in living subjects. Bioconjug Chem. 2010
Kimura T, Koya RC, Anselmi L, Sternini C, Wang HJ, Comin-Anduix B, Prins RM, Faure-Kumar E, Rozengurt N,
Cui Y, Kasahara N, Stripecke R. Lentiviral vectors with cmv or mhcii promoters administered in vivo: Immune
reactivity versus persistence of expression. Mol Ther. 2007
King PJ, Marien A, Janssen L, Floren W, Kumari R, Watson S, Andries L, Angibaud P, Page M, Arts J.
Jnj-26481585: A novel "second-generation" oral pan-histone deacetylase (hdac) in clinical development shows
preclinical anti-tumor activity against prostate cancer. Proceedings of the American Association for Cancer
Research Annual Meeting. 2009;50:1358
Kinsey M, Smith R, Lessnick S. Nr0b1 is required for the oncogenic phenotype mediated by ews/fli in ewing's
sarcoma. Molecular Cancer Research. 2006;4:851
Kioi M, Shimamura T, Nakashima H, Hirota M, Tohnai I, Husain SR, Puri RK. Il-13 cytotoxin has potent antitumor
activity and synergizes with paclitaxel in a mouse model of oral squamous cell carcinoma. International Journal
of Cancer. 2009;124:1440-1448
Kirby AC, Beattie L, Maroof A, van Rooijen N, Kaye PM. Signr1-negative red pulp macrophages protect against
acute streptococcal sepsis after leishmania donovani-induced loss of marginal zone macrophages. American
Journal of Pathology. 2009;175:1107-1115
Kirn D, Wang Y, Liang W, Contag C, Thorne S. Enhancing poxvirus oncolytic effects through increased spread
and immune evasion. Cancer Res. 2008;68:2071
Kisseberth W, Nadella M, Breen M, Thomas R, Duke S, Murahari S, Kosarek C, Vernau W, Avery A, Burkhard M. A
novel canine lymphoma cell line: A translational and comparative model for lymphoma research. Leukemia
Research. 2007;31:1709-1720
Kizaka-Kondoh S, Itasaka S, Zeng L, Tanaka S, Zhao T, Takahashi Y, Shibuya K, Hirota K, Semenza GL, Hiraoka M.
Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and
metastatic pancreatic cancer. Clin Cancer Res. 2009;15:3433-3441
Kizaka-Kondoh S, Kuchimaru T, Kadonosono T. Pathophysiological response to hypoxia — from the
molecular mechanisms of malady to drug discovery:Hypoxia-inducible factor-1 (hif-1)-active cells as a target for
cancer therapy. Journal of Pharmacological Sciences. 2011;115:440-445
Kleiman RJ, Kimmel LH, Bove SE, Lanz TA, Harms JF, Romegialli A, Miller KS, Willis A, des Etages S, Kuhn M,
Schmidt CJ. Chronic suppression of phosphodiesterase 10a alters striatal expression of genes responsible for
neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in huntington's disease. J
Pharmacol Exp Ther. 2011;336:64-76
Klein RL, Dayton RD, Leidenheimer NJ, Jansen K, Golde TE, Zweig RM. Efficient neuronal gene transfer with aav8
leads to neurotoxic levels of tau or green fluorescent proteins. Mol Ther. 2006;13:517-527
Klein RL, Dayton RD, Tatom JB, Henderson KM, Henning PP. Aav8, 9, rh10, rh43 vector gene transfer in the rat
brain: Effects of serotype, promoter and purification method. Mol Ther. 2008;16:89-96
Kleiner-Hancock HE, Shi R, Remeika A, Robbins D, Prince M, Gill JN, Syed Z, Adegboyega P, Mathis JM, Clifford
JL. Effects of atra combined with citrus and ginger-derived compounds in human scc xenografts. BMC Cancer.
1275.
1276.
1277.
1278.
1279.
1280.
1281.
1282.
1283.
1284.
1285.
1286.
1287.
1288.
1289.
1290.
1291.
1292.
1293.
1294.
1295.
1296.
1297.
1298.
1299.
2010;10:394
Klopp AH, Spaeth EL, Dembinski JL, Woodward WA, Munshi A, Meyn RE, Cox JD, Andreeff M, Marini FC. Tumor
irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment.
Cancer Res. 2007;67:11687-11695
Klose A, Waerzeggers Y, Monfared P, Vukicevic S, Kaijzel EL, Winkeler A, Wickenhauser C, Lowik CW, Jacobs
AH. Imaging bone morphogenetic protein 7 induced cell cycle arrest in experimental gliomas. Neoplasia.
2011;13:276-285
Klumpp M, Mayr L. Trends in drug discovery technologies-conference report from miptec 2006. Expert Opin.
Drug Discov. 2006;1:361-364
Knapp D, Filion B, Filion M, Phillips N. Antitumor activity of mycobacterial cell wall DNA complex (mcc)
against canine urinary bladder transitional cell carcinoma cells. Veterinary and Comparative Oncology.
2005;3:46-47
Knostman KA, Venkateswaran A, Zimmerman B, Capen CC, Jhiang SM. Creation and characterization of a
doxycycline-inducible mouse model of thyroid-targeted ret/ptc1 oncogene and luciferase reporter gene
coexpression. Thyroid. 2007;17:1181-1188
Ko IK, Ziady A, Lu S, Kwon YJ. Acid-degradable cationic methacrylamide polymerized in the presence of plasmid
DNA as tunable non-viral gene carrier. Biomaterials. 2008;29:3872-3881
Ko MH, Kim S, Hwang do W, Ko HY, Kim YH, Lee DS. Bioimaging of the unbalanced expression of microrna9 and
microrna9* during the neuronal differentiation of p19 cells. Febs J. 2008;275:2605-2616
Kobayashi M, Okada T, Murakami T, Ozawa K, Kobayashi E, Morita T. Tissue-targeted in vivo gene transfer
coupled with histone deacetylase inhibitor depsipeptide (fk228) enhances adenoviral infection in rat renal
cancer allograft model systems. Urology. 2007;70:1230-1236
Kodama M, Tsukamoto K, Yoshida K, Aoki K, Kanegasaki S, Quinn G. Embryonic stem cell transplantation
correlates with endogenous neurogenin 3 expression and pancreas regeneration in streptozotocin-injured mice. J
Histochem Cytochem. 2009;57:1149-1158
Kohrt HE, Houot R, Goldstein MJ, Weiskopf K, Alizadeh AA, Brody J, Muller A, Pachynski R, Czerwinski D,
Coutre S, Chao MP, Chen L, Tedder TF, Levy R. Cd137 stimulation enhances the antilymphoma activity of anticd20 antibodies. Blood. 2011;117:2423-2432
Kolesnikova TV, Kazarov AR, Lemieux ME, Lafleur MA, Kesari S, Kung AL, Hemler ME. Glioblastoma inhibition
by cell surface immunoglobulin protein ewi-2, in vitro and in vivo1,2. Neoplasia. 2009;11:77-86
Kolka JA, Vreede AP, Roessler BJ. Lipopolysaccharide recognition protein, md-2, facilitates cellular uptake of e.
Coli-derived plasmid DNA in synovium. J Gene Med. 2005;7:956-964
Kominsky S, Tyler B, Sosnowski J, Brady K, Doucet M, Nell D, Smedley J, McClane B, Brem H, Sukumar S.
Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis. Cancer Res.
2007;67:7977
Kong Y, Akin AR, Francis KP, Zhang N, Troy TL, Xie H, Rao J, Cirillo SL, Cirillo JD. Whole-body imaging of
infection using fluorescence. Current protocols in microbiology. 2011;Chapter 2:Unit 2C 3
Kong Y, Hequan Yao, Hongjun Ren, Subbian S, Suat L. G. Cirillo, James C. Sacchettini, Jianghong Rao, Cirillo
JD. Imaging tuberculosis with endogenous β-lactamase reporter enzyme fluorescence in live mice. Proceedings
of the National Academy of Sciences of the United States of America. 2010;107:12239-12244
Kong Y, Shi Y, Chang M, Akin AR, Francis KP, Zhang N, Troy TL, Yao H, Rao J, Cirillo SL, Cirillo JD. Wholebody imaging of infection using bioluminescence. Current protocols in microbiology. 2011;Chapter 2:Unit 2C
4
Kong Y, Subbian S, Cirillo SL, Cirillo JD. Application of optical imaging to study of extrapulmonary spread by
tuberculosis. Tuberculosis (Edinb). 2009;89 Suppl 1:S15-17
Konopleva M, Shi Y, Steelman LS, Shelton JG, Munsell M, Marini F, McQueen T, Contractor R, McCubrey JA,
Andreeff M. Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for
the treatment of raf-transformed hematopoietic cells. Cancer Res. 2005;65:9962-9970
Koo V, Hamilton P, Williamson K. Non-invasive in vivo imaging in small animal research. Cellular Oncology.
2006;28:127-139
Koo V, Lee A, Eldin OS, Watson C, Hamilton P, Williamson K. Pcdna3.1tdtomato is superior to pdsred2-n1 for
optical fluorescence imaging in the f344/ay-27 rat model of bladder cancer. Mol Imaging Biol. 2010;12:509-519
Kopanja D, Stoyanova T, Okur NM, Huang E, Bagchi S, Raychaudhuri P. Proliferation defects and genome
instability in cells lacking cul4a. Oncogene. 2009;28:2456-2465
Kormann MS, Hasenpusch G, Aneja MK, Nica G, Flemmer AW, Herber-Jonat S, Huppmann M, Mays LE, Illenyi M,
Schams A, Griese M, Bittmann I, Handgretinger R, Hartl D, Rosenecker J, Rudolph C. Expression of therapeutic
proteins after delivery of chemically modified mrna in mice. Nature biotechnology. 2011;29:154-157
Kornberg A, Dietz O, Mau H, Stangl M, Pascher A, Scheele J, Hammer C. Metabolic function and capability of
regeneration of xenogeneic perfused pig livers: Judgement of organ function during autologous reperfusion.
Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft. 1999;11:94-100
Korpal M, Yan J, Lu X, Xu S, Lerit DA, Kang Y. Imaging transforming growth factor-beta signaling dynamics and
therapeutic response in breast cancer bone metastasis. Nat Med. 2009;15:960-966
Koski A, Rajecki M, Guse K, Kanerva A, Ristimäki A, Pesonen S, Escutenaire S, Hemminki A. Systemic adenoviral
gene delivery to orthotopic murine breast tumors with ablation of coagulation factors, thrombocytes and kupffer
1300.
1301.
1302.
1303.
1304.
1305.
1306.
1307.
1308.
1309.
1310.
1311.
1312.
1313.
1314.
1315.
1316.
1317.
1318.
1319.
1320.
1321.
cells. The Journal of Gene Medicine. 2009;11:966-977
Koto K, Horie N, Kimura S, Murata H, Sakabe T, Matsui T, Watanabe M, Adachi S, Maekawa T, Fushiki S, Kubo T.
Clinically relevant dose of zoledronic acid inhibits spontaneous lung metastasis in a murine osteosarcoma
model. Cancer Lett. 2009;274:271-278
Kovar J, Simpson M, Schutz-Geschwender A, Olive D. A systematic approach to the development of fluorescent
contrast agents for optical imaging of mouse cancer models. Analytical Biochemistry. 2007;367:1-12
Kowolik C, Topp M, Gonzalez S, Pfeiffer T, Olivares S, Gonzalez N, Smith D, Forman S, Jensen M, Cooper L. Cd28
costimulation provided through a cd19-specific chimeric antigen receptor enhances in vivo persistence and
antitumor efficacy of adoptively transferred t cells. Cancer Res. 2006;66:10995
Koya RC, Mok S, Comin-Anduix B, Chodon T, Radu CG, Nishimura MI, Witte ON, Ribas A. Kinetic phases of
distribution and tumor targeting by t cell receptor engineered lymphocytes inducing robust antitumor
responses. Proceedings of the National Academy of Sciences of the United States of America.
2010;107:14286-14291
Krespi YP, Kizhner V, Nistico L, Hall-Stoodley L, Stoodley P. Laser disruption and killing of methicillinresistant staphylococcus aureus biofilms. Am J Otolaryngol. 2011;32:198-202
Krishnan M, Park J, Cao F, Wang D, Paulmurugan R, Tseng J, Gonzalgo M, Gambhir S, Wu J. Effects of epigenetic
modulation on reporter gene expression: Implications for stem cell imaging. The FASEB Journal. 2005:05
Krom YD, Fallaux FJ, Que I, Lowik C, van Dijk KW. Efficient in vivo knock-down of estrogen receptor alpha:
Application of recombinant adenovirus vectors for delivery of short hairpin rna. BMC Biotechnol. 2006;6:11
Krug A, Luker G, Barchet W, Leib D, Akira S, Colonna M. Herpes simplex virus type 1 activates murine natural
interferon-producing cells through toll-like receptor 9. Blood. 2004;103:1433
Kruschinski A, Moosmann A, Poschke I, Norell H, Chmielewski M, Seliger B, Kiessling R, Blankenstein T, Abken
H, Charo J. Engineering antigen-specific primary human nk cells against her-2 positive carcinomas. Proceedings
of the National Academy of Sciences of the United States of America. 2008;105:17481-17486
Kruse DE, Mackanos MA, O'Connell-Rodwell CE, Contag CH, Ferrara KW. Short-duration-focused ultrasound
stimulation of hsp70 expression in vivo. Phys Med Biol. 2008;53:3641-3660
Krzyzaniak M, Peterson C, Loomis W, Hageny AM, Wolf P, Reys L, Putnam J, Eliceiri B, Baird A, Bansal V,
Coimbra R. Postinjury vagal nerve stimulation protects against intestinal epithelial barrier breakdown. The
Journal of trauma. 2011;70:1168-1175; discussion 1175-1166
Krzyzaniak MJ, Peterson CY, Cheadle G, Loomis W, Wolf P, Kennedy V, Putnam JG, Bansal V, Eliceiri B, Baird A,
Coimbra R. Efferent vagal nerve stimulation attenuates acute lung injury following burn: The importance of the
gut-lung axis. Surgery. 2011
Kudo T, Ueda M, Kuge Y, Mukai T, Tanaka S, Masutani M, Kiyono Y, Kizaka-Kondoh S, Hiraoka M, Saji H.
Imaging of hif-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in
hif-1-active tumor cells. J Nucl Med. 2009;50:942-949
Kuklin NA, Clark DJ, Secore S, Cook J, Cope LD, McNeely T, Noble L, Brown MJ, Zorman JK, Wang XM, Pancari
G, Fan H, Isett K, Burgess B, Bryan J, Brownlow M, George H, Meinz M, Liddell ME, Kelly R, Schultz L,
Montgomery D, Onishi J, Losada M, Martin M, Ebert T, Tan CY, Schofield TL, Nagy E, Meineke A, Joyce JG, Kurtz
MB, Caulfield MJ, Jansen KU, McClements W, Anderson AS. A novel staphylococcus aureus vaccine: Iron surface
determinant b induces rapid antibody responses in rhesus macaques and specific increased survival in a murine
s. Aureus sepsis model. Infection and Immunity. 2006;74:2215-2223
Kuklin NA, Pancari GD, Tobery TW, Cope L, Jackson J, Gill C, Overbye K, Francis KP, Yu J, Montgomery D,
Anderson AS, McClements W, Jansen KU. Real-time monitoring of bacterial infection in vivo: Development of
bioluminescent staphylococcal foreign-body and deep-thigh-wound mouse infection models. Antimicrobial
Agents and Chemotherapy. 2003;47:2740-2748
Kulbe H, Thompson R, Wilson JL, Robinson S, Hagemann T, Fatah R, Gould D, Ayhan A, Balkwill F. The
inflammatory cytokine tumor necrosis factor-α generates an autocrine tumor-promoting network in epithelial
ovarian cancer cells. Cancer Res. 2007;67:585-592
Kumagai G, Okada Y, Yamane J, Nagoshi N, Kitamura K, Mukaino M, Tsuji O, Fujiyoshi K, Katoh H, Okada S,
Shibata S, Matsuzaki Y, Toh S, Toyama Y, Nakamura M, Okano H. Roles of es cell-derived gliogenic neural stem/
progenitor cells in functional recovery after spinal cord injury. PLoS One. 2009;4
Kumar P, Yadav A, Patel SN, Islam M, Pan Q, Merajver SD, Teknos TN. Tetrathiomolybdate inhibits head and neck
cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis. Mol
Cancer. 2010;9:206
Kumar S, Wan C, Ramaswamy G, Clemens TL, Ponnazhagan S. Mesenchymal stem cells expressing osteogenic and
angiogenic factors synergistically enhance bone formation in a mouse model of segmental bone defect. Mol Ther.
2010
Kumar V, Behera R, Lohite K, Karnik S, Kundu G. P38 kinase is crucial for osteopontin-induced furin expression
that supports cervical cancer progression. Cancer Res. 2010
Kundu B, Stolin A, Pole J, Baumgart L, Fontaine M, Wojcik R, Kross B, Zorn C, Majewski S, Williams M. Trimodality small animal imaging system. Nuclear Science, IEEE Transactions on. 2006;53:66-70
Kung AL, Zabludoff SD, France DS, Freedman SJ, Tanner EA, Vieira A, Cornell-Kennon S, Lee J, Wang B, Wang J,
Memmert K, Naegeli HU, Petersen F, Eck MJ, Bair KW, Wood AW, Livingston DM. Small molecule blockade of
transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell. 2004;6:33-43
1322.
1323.
1324.
1325.
1326.
1327.
1328.
1329.
1330.
1331.
1332.
1333.
1334.
1335.
1336.
1337.
1338.
1339.
1340.
1341.
1342.
1343.
1344.
Kunnumakkara A, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal B, Guha S. Curcurnin potentiates anti-tumor
activity of gerneitabine in an orthotopic model of pancreatic cancer: Role in inhibition of proliferation,
angiogenesis, and nf-kappa b regulated gene products. Gastroenterology. 2007;132:A433
Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB. Curcumin potentiates
antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of
proliferation, angiogenesis, and inhibition of nuclear factor-kappab-regulated gene products. Cancer Res.
2007;67:3853-3861
Kuns RD, Morris ES, MacDonald KPA, Markey KA, Morris HM, Raffelt NC, Banovic T, Don ALJ, Rowe V, Burman
AC, Clouston AD, Farah C, Besra GS, Illarionov PA, Smyth MJ, Porcelli SA, Hill GR. Invariant natural killer t
cell–natural killer cell interactions dictate transplantation outcome after α-galactosylceramide administration.
Blood. 2009;113:5999-6010
Kuo C, Coquoz O, Troy TL, Xu H, Rice BW. Three-dimensional reconstruction of in vivo bioluminescent sources
based on multispectral imaging. J Biomed Opt. 2007;12:024007
Kupferman ME, Jiffar T, El-Naggar A, Yilmaz T, Zhou G, Xie T, Feng L, Wang J, Holsinger FC, Yu D, Myers JN.
Trkb induces emt and has a key role in invasion of head and neck squamous cell carcinoma. Oncogene. 2010
Kupperman E, Lee EC, Cao Y, Bannerman B, Fitzgerald M, Berger A, Yu J, Yang Y, Bruzzese F, Liu J, Blank J,
Garcia K, Tsu C, Dick L, Fleming P, Yu L, Manfredi M, Rolfe M, Bolen J. Evaluation of the proteasome inhibitor
mln9708 in preclinical models of human cancer. Cancer Res. 2010;70:1970-1980
Kutscher HL, Chao P, Deshmukh M, Singh Y, Hu P, Joseph LB, Reimer DC, Stein S, Laskin DL, Sinko PJ.
Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats. J Control
Release. 2009;143:31-37
Kutschka I, Chen I, Kofidis T, Arai T, von Degenfeld G, Sheikh A, Hendry S, Pearl J, Hoyt G, Sista R. Collagen
matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of
ischemic rat hearts. Circulation. 2006;114
Kutschka I, Chen IY, Kofidis T, von Degenfeld G, Sheikh AY, Hendry SL, Hoyt G, Pearl J, Blau HM, Gambhir SS,
Robbins RC. In vivo optical bioluminescence imaging of collagen-supported cardiac cell grafts. J Heart Lung
Transplant. 2007;26:273-280
Kutschka I, Kofidis T, Chen IY, von Degenfeld G, Zwierzchoniewska M, Hoyt G, Arai T, Lebl DR, Hendry SL,
Sheikh AY, Cooke DT, Connolly A, Blau HM, Gambhir SS, Robbins RC. Adenoviral human bcl-2 transgene
expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts.
Circulation. 2006;114:I-174-180
Kwak M, Hur K, Yu J, Han T, Yanagihara K, Kim W, Lee S, Song S, Yang H. Suppression of in vivo tumor growth
by using a biodegradable thermosensitive hydrogel polymer containing chemotherapeutic agent.
Investigational New Drugs. 2010;28:284-290
Kwon GT, Jung JI, Song HR, Woo EY, Jun JG, Kim JK, Her S, Park JH. Piceatannol inhibits migration and
invasion of prostate cancer cells: Possible mediation by decreased interleukin-6 signaling. The Journal of
nutritional biochemistry. 2011
Kwon J, Park I, Cho A, Shin S, Hong M, Jeong S, Kim Y, Min J, Jeong M. Enhanced angiogenesis mediated by
vascular endothelial growth factor plasmid-loaded thermo-responsive amphiphilic polymer in a rat myocardial
infarction model. Journal of Controlled Release. 2009;138:168-176
Kwon SM, Nam HY, Nam T, Park K, Lee S, Kim K, Kwon IC, Kim J, Kang D, Park JH, Jeong SY. In vivo timedependent gene expression of cationic lipid-based emulsion as a stable and biocompatible non-viral gene carrier.
J Control Release. 2008;128:89-97
Kwong K, Kloetzer L, Wong K, Ren J, Kuo B, Jiang Y, Chen Y, Chan S, Young G, Wong S. Bioluminescence
imaging of heme oxygenase-1 upregulation in the gua sha procedure. Journal of Visualized Experiments. 2009
Laakkonen P, Waltari M, Holopainen T, Takahashi T, Pytowski B, Steiner P, Hicklin D, Persaud K, Tonra JR, Witte
L, Alitalo K. Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth. Cancer
Res. 2007;67:593-599
Labrinidis A, Diamond P, Martin S, Hay S, Liapis V, Zinonos I, Sims NA, Atkins GJ, Vincent C, Ponomarev V,
Findlay DM, Zannettino AC, Evdokiou A. Apo2l/trail inhibits tumor growth and bone destruction in a murine
model of multiple myeloma. Clin Cancer Res. 2009;15:1998-2009
Labrinidis A, Hay S, Liapis V, Ponomarev V, Findlay D, Evdokiou A. Zoledronic acid inhibits both the osteolytic
and osteoblastic components of osteosarcoma lesions in a mouse model. Clinical Cancer Research.
2009;15:3451
Lalancette-He bert M, Moquin A, Choi A, Kriz J, Maysinger D. Lipopolysaccharide-qd micelles induce marked
induction of tlr2 and lipid droplet accumulation in olfactory bulb microglia. Molecular Pharmaceutics.
2010;7:1183-1194
Lalancette-Hebert M, Phaneuf D, Soucy G, Weng YC, Kriz J. Live imaging of toll-like receptor 2 response in
cerebral ischaemia reveals a role of olfactory bulb microglia as modulators of inflammation. Brain. 2009
Lalani AS, Chang B, Lin J, Case SS, Luan B, Wu-Prior WW, VanRoey M, Jooss K. Anti-tumor efficacy of human
angiostatin using liver-mediated adeno-associated virus gene therapy. Mol Ther. 2004;9:56-66
Lambert H, Dellacasa-Lindberg I, Barragan A. Migratory responses of leukocytes infected with toxoplasma
gondii. Microbes and Infection. 2010
Lambert H, Hitziger N, Dellacasa I, Svensson M, Barragan A. Induction of dendritic cell migration upon
1345.
1346.
1347.
1348.
1349.
1350.
1351.
1352.
1353.
1354.
1355.
1356.
1357.
1358.
1359.
1360.
1361.
1362.
1363.
1364.
1365.
1366.
1367.
1368.
1369.
1370.
1371.
toxoplasma gondii infection potentiates parasite dissemination. Cellular Microbiology. 2006;8:1611-1623
Lan K, Yen S, Liu R, Shih H, Tseng F, Lan K. Mutant bik gene transferred by cationic liposome inhibits peritoneal
disseminated murine colon cancer. Clinical and Experimental Metastasis. 2007;24:461-470
Lan KL, Lan KH, Sheu ML, Chen MY, Shih YS, Hsu FC, Wang HM, Liu RS, Yen SH. Honokiol inhibits hypoxiainducible factor-1 pathway. International journal of radiation biology. 2011;87:579-590
Lane MC, Alteri CJ, Smith SN, Mobley HLT. Expression of flagella is coincident with uropathogenic escherichia
coli ascension to the upper urinary tract. Proceedings of the National Academy of Sciences of the United States
of America. 2007;104:16669-16674
Lang T, Goyard S, Lebastard M, Milon G. Bioluminescent leishmania expressing luciferase for rapid and high
throughput screening of drugs acting on amastigote harbouring macrophages and for quantitative real time
monitoring of parasitism features in living mice. Cellular Microbiology. 2005;7:383-392
Lankes H, Zanghi C, Santos K, Capella C, Duke C, Dewhurst S. In vivo gene delivery and expression by
bacteriophage lambda vectors. Journal of Applied Microbiology. 2007;102:1337-1349
Lapteva N, Seethammagari MR, Hanks BA, Jiang J, Levitt JM, Slawin KM, Spencer DM. Enhanced activation of
human dendritic cells by inducible cd40 and toll-like receptor-4 ligation. Cancer Res. 2007;67:10528-10537
Lassailly F, Griessinger E, Bonnet D. " Microenvironmental contaminations" induced by fluorescent lipophilic
dyes used for noninvasive in vitro and in vivo cell tracking. Blood. 2010;115:5347-5354
Lau YK, Murray LB, Houshmandi SS, Xu Y, Gutmann DH, Yu Q. Merlin is a potent inhibitor of glioma growth.
Cancer Res. 2008;68:5733-5742
Laurie NA, Gray JK, Zhang J, Leggas M, Relling M, Egorin M, Stewart C, Dyer MA. Topotecan combination
chemotherapy in two new rodent models of retinoblastoma. Clin Cancer Res. 2005;11:7569-7578
Lauritzen KH, Moldestad O, Eide L, Carlsen H, Nesse G, Storm JF, Mansuy IM, Bergersen LH, Klungland A.
Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior.
Mol Cell Biol. 2010;30:1357-1367
Law JH, Whigham AS, Wirth PS, Liu D, Pham MQ, Vadivelu S, Kirkbride KC, Brown BT, Burkey BB, Sinard RJ,
Netterville JL, Yarbrough WG. Human-in-mouse modeling of primary head and neck squamous cell carcinoma.
Laryngoscope. 2009;119:2315-2323
Lawson D, Xin L, Lukacs R, Xu Q, Cheng D, Witte O. Prostate stem cells and prostate cancer. Cold Spring Harb
Symp Quant Biol. . 2005;70:187-196
Lawson W, Polosukhin V, Zoia O, Stathopoulos G, Han W, Plieth D, Loyd J, Neilson E, Blackwell T.
Characterization of fibroblast-specific protein 1 in pulmonary fibrosis. American Journal of Respiratory and
Critical Care Medicine. 2005;171:899
Laxman B, Hall DE, Bhojani MS, Hamstra DA, Chenevert TL, Ross BD, Rehemtulla A. Noninvasive real-time
imaging of apoptosis. Proc Natl Acad Sci U S A. 2002;99:16551-16555
Layzer JM, McCaffrey AP, Tanner AK, Huang Z, Kay MA, Sullenger BA. In vivo activity of nuclease-resistant
sirnas. RNA. 2004;10:766-771
Le Boeuf F, Diallo JS, McCart JA, Thorne S, Falls T, Stanford M, Kanji F, Auer R, Brown CW, Lichty BD, Parato K,
Atkins H, Kirn D, Bell JC. Synergistic interaction between oncolytic viruses augments tumor killing. Molecular
therapy : the journal of the American Society of Gene Therapy. 2010;18:888-895
Le Devedec SE, Lalai R, Pont C, de Bont H, van de Water B. Two-photon intravital multicolor imaging combined
with inducible gene expression to distinguish metastatic behavior of breast cancer cells in vivo. Molecular
imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2011;13:67-77
Le Devedec SE, van Roosmalen W, Maria N, Grimbergen M, Pont C, Lalai R, van de Water B. An improved model
to study tumor cell autonomous metastasis programs using mtln3 cells and the rag2(-/-) gammac (-/-) mouse.
Clin Exp Metastasis. 2009;26:673-684
Le U, Bom H, Moon S, Ahn Y, Kim Y, Joo S, Hong M, Jeong M, Song H, Min J. Monitoring prolongation of
cardiac stem cell survival after pharmaceutical/genetic intervention using cooled ccd bioluminescence imaging.
J Nucl Med. 2006;47:259P
Le U, Bom H, Moon S, Ahn Y, Kim Y, Joo S, Hong M, Jeong M, Song H, Min J. Bioluminescence imaging of the
prolongation of cardiac stem cell survival with pharmaceutical and genetic intervention. J Nucl Med.
2007;48:167P
Le U, Bom H, Moon S, Park K, Han H, Lee H, Song H, Min J. In vivo imaging of embryonic stem cell implantation
into rat corpus cavernosum by using optical imaging system. J Nucl Med. 2007;48:327P
Leblond F, Davis SC, Valdes PA, Pogue BW. Pre-clinical whole-body fluorescence imaging: Review of
instruments, methods and applications. J Photochem Photobiol B. 2010;98:77-94
Lecoeur H, Buffet P, Morizot G, Goyard S, Guigon G, Milon G, Lang T. Optimization of topical therapy for
leishmania major localized cutaneous leishmaniasis using a reliable c57bl/6 model. PLoS Negl Trop Dis. 2007;1
Lecoeur H, Buffet PA, Milon G, Lang T. Early curative applications of the aminoglycoside wr279396 on an
experimental leishmania major-loaded cutaneous site do not impair the acquisition of immunity. Antimicrob
Agents Chemother. 2010;54:984-990
Lee AS, Tang C, Cao F, Xie X, van der Bogt K, Hwang A, Connolly AJ, Robbins RC, Wu JC. Effects of cell number
on teratoma formation by human embryonic stem cells. Cell Cycle. 2009;8:2608-2612
Lee AS, Wu JC. Imaging of embryonic stem cell migration in vivo. Methods Mol Biol. 2011;750:101-114
Lee B, Fujita M, Khazenzon N, Wawrowsky K, Wachsmann-Hogiu S, Farkas D, Black K, Ljubimova J, Holler E.
1372.
1373.
1374.
1375.
1376.
1377.
1378.
1379.
1380.
1381.
1382.
1383.
1384.
1385.
1386.
1387.
1388.
1389.
1390.
1391.
1392.
1393.
1394.
1395.
Polycefin, a new prototype of a multifunctional nanoconjugate based on poly ( -l-malic acid) for drug delivery.
Bioconjugate Chem. 2006;17:317-326
Lee CJ, Spalding AC, Ben-Josef E, Wang L, Simeone DM. In vivo bioluminescent imaging of irradiated
orthotopic pancreatic cancer xenografts in nonobese diabetic-severe combined immunodeficient mice: A novel
method for targeting and assaying efficacy of ionizing radiation. Transl Oncol. 2010;3:153-159
Lee CM, Jang D, Cheong SJ, Kim EM, Jeong MH, Kim SH, Kim DW, Lim ST, Sohn MH, Jeong HJ. Surface
engineering of quantum dots for in vivo imaging. Nanotechnology. 2010;21:285102
Lee CM, Kim EM, Cheong SJ, Kim DW, Lim ST, Sohn MH, Jeong HJ. Targeted molecular imaging of vegf receptors
overexpressed in ischemic microvasculature using chitosan-dc101 conjugates. J Biomed Mater Res A.
2009;92:1510-1517
Lee D, Anderson M, Wu S, Lee J. Development of an adenoviral vaccine against e6 and e7 oncoproteins to prevent
growth of human papillomavirus-positive cancer. Archives of Otolaryngology- Head and Neck Surgery.
2008;134:1316
Lee D, Erigala VR, Dasari M, Yu J, Dickson RM, Murthy N. Detection of hydrogen peroxide with
chemiluminescent micelles. International journal of nanomedicine. 2008;3:471-476
Lee D, Khaja S, Velasquez-Castano JC, Dasari M, Sun C, Petros J, Taylor WR, Murthy N. In vivo imaging of
hydrogen peroxide with chemiluminescent nanoparticles. Nat Mater. 2007;6:765-769
Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC,
Ding Q, Su JL, Yang JY, Sahin AA, Hortobagyi GN, Tsai FJ, Tsai CH, Hung MC. Ikk beta suppression of tsc1 links
inflammation and tumor angiogenesis via the mtor pathway. Cell. 2007;130:440-455
Lee G, Lo A, Short SA, Mankelow TJ, Spring F, Parsons SF, Yazdanbakhsh K, Mohandas N, Anstee DJ, Chasis JA.
Targeted gene deletion demonstrates that the cell adhesion molecule icam-4 is critical for erythroblastic island
formation. Blood. 2006;108:2064-2071
Lee H, Kim SI, Shin D, Yoon Y, Choi TH, Cheon GJ, Kim M. Hepatic sirna delivery using recombinant human
apolipoprotein a-i in mice. Biochem Biophys Res Commun. 2009;378:192-196
Lee H, Lee K, Kim IK, Park TG. Synthesis, characterization, and in vivo diagnostic applications of hyaluronic acid
immobilized gold nanoprobes. Biomaterials. 2008;29:4709-4718
Lee H, Yu MK, Park S, Moon S, Min JJ, Jeong YY, Kang HW, Jon S. Thermally cross-linked superparamagnetic
iron oxide nanoparticles: Synthesis and application as a dual imaging probe for cancer in vivo. J Am Chem Soc.
2007;129:12739-12745
Lee HJ, Kim EH, Seo WD, Choi TH, Cheon GJ, Lee YJ, Lee YS. Heat shock protein 27-targeted heptapeptide of the
pkcdelta catalytic v5 region sensitizes tumors with radio- and chemoresistance. International journal of
radiation oncology, biology, physics. 2011;80:221-230
Lee HJ, Lee YJ, Kwon HC, Bae S, Kim SH, Min JJ, Cho CK, Lee YS. Radioprotective effect of heat shock protein 25
on submandibular glands of rats. American Journal of Pathology. 2006;169:1601-1611
Lee J, Bogyo M. Development of near-infrared fluorophore (nirf)-labeled activity-based probes for in vivo
imaging of legumain. ACS Chem Biol. 2010;5:233-243
Lee J, Borboa AK, Baird A, Eliceiri BP. Non-invasive quantification of brain tumor-induced astrogliosis. BMC
neuroscience. 2011;12:9
Lee J-J, Gonçalves A, Smith BA, Palumbo R, White AG, Smith BD. Singlet oxygen release and cell toxicity of a
chemiluminescent squaraine rotaxane dye: Implications for molecular imaging. Australian Journal of
Chemistry. 2011;64:604-610
Lee JC, Hayman E, Pegram HJ, Santos E, Heller G, Sadelain M, Brentjens R. In vivo inhibition of human cd19targeted effector t cells by natural t regulatory cells in a xenotransplant murine model of b cell malignancy.
Cancer Res. 2011;71:2871-2881
Lee JD, Hempel N, Lee NY, Blobe GC. The type iii tgf-beta receptor suppresses breast cancer progression through
gipc-mediated inhibition of tgf-beta signaling. Carcinogenesis. 2010;31:175-183
Lee JH, Sancar A. From the cover: Circadian clock disruption improves the efficacy of chemotherapy through
p73-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America.
2011;108:10668-10672
Lee JS, Li Q, Lee JY, Lee SH, Jeong JH, Lee HR, Chang H, Zhou FC, Gao SJ, Liang C, Jung JU. Flip-mediated
autophagy regulation in cell death control. Nat Cell Biol. 2009;11:1355-1362
Lee JW, Han HD, Shahzad MMK, Kim SW, Mangala LS, Nick AM, Lu C, Langley RR, Schmandt R, Kim HS, Mao S,
Gooya J, Fazenbaker C, Jackson D, Tice DA, Landen CN, Coleman RL, Sood AK. Epha2 immunoconjugate as
molecularly targeted chemotherapy for ovarian carcinoma. Journal of the National Cancer Institute.
2009;101:1193-1205
Lee JY, Kim S, Hwang DW, Jeong JM, Chung JK, Lee MC, Lee DS. Development of a dual-luciferase reporter
system for in vivo visualization of microrna biogenesis and posttranscriptional regulation. J Nucl Med.
2008;49:285-294
Lee K, Kim JD, Lee CY, Her S, Jung H. A high-capacity, hybrid electro-microneedle for in-situ cutaneous gene
transfer. Biomaterials. 2011
Lee K, Moffat B, Schott A, Layman R, Ellingworth S, Juliar R, Khan A, Helvie M, Meyer C, Chenevert T.
Prospective early response imaging biomarker for neoadjuvant breast cancer chemotherapy. Clinical Cancer
Research. 2007;13:443
1396.
1397.
1398.
1399.
1400.
1401.
1402.
1403.
1404.
1405.
1406.
1407.
1408.
1409.
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1411.
1412.
1413.
1414.
1415.
1416.
1417.
1418.
1419.
1420.
Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. Anthracycline chemotherapy inhibits hif-1 transcriptional
activity and tumor-induced mobilization of circulating angiogenic cells. Proceedings of the National Academy
of Sciences of the United States of America. 2009;106:2353-2358
Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Acriflavine inhibits hif-1 dimerization, tumor growth, and
vascularization. Proceedings of the National Academy of Sciences of the United States of America.
2009;106:17910-17915
Lee KC, Hamstra DA, Bhojani MS, Khan AP, Ross BD, Rehemtulla A. Noninvasive molecular imaging sheds light
on the synergy between 5-fluorouracil and trail/apo2l for cancer therapy. Clin Cancer Res. 2007;13:1839-1846
Lee KC, Sud S, Meyer CR, Moffat BA, Chenevert TL, Rehemtulla A, Pienta KJ, Ross BD. An imaging biomarker of
early treatment response in prostate cancer that has metastasized to the bone. Cancer Res. 2007;67:3524-3528
Lee MH, Lee WH, Todorov I, Liu CP. Cd4+ cd25+ regulatory t cells prevent type 1 diabetes preceded by dendritic
cell-dominant invasive insulitis by affecting chemotaxis and local invasiveness of dendritic cells. Journal of
immunology. 2010;185:2493-2501
Lee MH, Lee WH, Van Y, Contag CH, Liu CP. Image-guided analyses reveal that non-cd4 splenocytes contribute
to cd4+ t cell-mediated inflammation leading to islet destruction by altering their local function and not
systemic trafficking patterns. Mol Imaging. 2007;6:369-383
Lee MJE, Veiseh O, Bhattarai N, Sun C, Hansen SJ, Ditzler S, Knoblaugh S, Lee D, Ellenbogen R, Zhang M, Olson
JM. Rapid pharmacokinetic and biodistribution studies using cholorotoxin-conjugated iron oxide
nanoparticles: A novel non-radioactive method. PLoS One. 2010;5
Lee S, Wang Z, Lin C, Contag C, Olds L, Cooper A, Sibley E. Regulation of intestine-specific spatiotemporal
expression by the rat lactase promoter. Journal of Biological Chemistry. 2002;277:13099
Lee SH, Hao E, Savinov AY, Geron I, Strongin AY, Itkin-Ansari P. Human beta-cell precursors mature into
functional insulin-producing cells in an immunoisolation device: Implications for diabetes cell therapies.
Transplantation. 2009;87:983-991
Lee SH, Hao E, Savinov AY, Geron I, Strongin AY, Itkin-Ansari P. Human β-cell precursors mature into functional
insulin-producing cells in an immunoisolation device: Implications for diabetes cell therapies.
Transplantation. 2009;87:983-991
Lee SW, Padmanabhan P, Ray P, Gambhir SS, Doyle T, Contag C, Goodman SB, Biswal S. Stem cell-mediated
accelerated bone healing observed with in vivo molecular and small animal imaging technologies in a model of
skeletal injury. J Orthop Res. 2009;27:295-302
Lee T, Poon R, Wo J, Ma S, Guan X, Myers J, Altevogt P, Yuen A. Lupeol suppresses cisplatin-induced nuclear
factor- b activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis
in an orthotopic nude mouse model. Cancer Res. 2007;67:8800
Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. Cd24(+) liver tumor-initiating cells drive self-renewal and
tumor initiation through stat3-mediated nanog regulation. Cell stem cell. 2011;9:50-63
Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. Lupeol targets liver tumor-initiating cells through
phosphatase and tensin homolog modulation. Hepatology. 2011;53:160-170
Lee W, Hwang J, Tseng Y, Wang H, Chang Y, Lu Y, Ting G, Whang-Peng J, Wang S. Therapeutic efficacy
evaluation of 111in-vnb-liposome on human colorectal adenocarcinoma ht-29/luc mouse xenografts. Nuclear
Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated
Equipment. 2006;569:497-504
Lee WY, Wei HJ, Lin WW, Yeh YC, Hwang SM, Wang JJ, Tsai MS, Chang Y, Sung HW. Enhancement of cell
retention and functional benefits in myocardial infarction using human amniotic-fluid stem-cell bodies enriched
with endogenous ecm. Biomaterials. 2011;32:5558-5567
Lee Z, Dennis JE, Gerson SL. Imaging stem cell implant for cellular-based therapies. Exp Biol Med (Maywood).
2008;233:930-940
Leevy WM, Gammon ST, Levchenko T, Daranciang DD, Murillo O, Torchilin V, Piwnica-Worms D, Huettner JE,
Gokel GW. Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile
channels in bacterial and mammalian cells. Org Biomol Chem. 2005;3:3544-3550
Leevy WM, Lambert TN, Johnson JR, Morris J, Smith BD. Quantum dot probes for bacteria distinguish
escherichia coli mutants and permit in vivo imaging. Chem Commun (Camb). 2008:2331-2333
Leevy WM, Serazin N, Smith BD. Optical imaging of bacterial infection models. Drug Discov Today Dis Models.
2007;4:91-97
Lehmann S, Stiehl DP, Honer M, Dominietto M, Keist R, Kotevic I, Wollenick K, Ametamey S, Wenger RH, Rudin
M. Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events.
Proceedings of the National Academy of Sciences of the United States of America. 2009;106:14004-14009
Leib D, Prior J, Song J, Luker G. Real-time imaging of hsv-1 tropism and spread. Investigative Ophtalmology and
Visual Science. 2003;44:4630.
Leja J, Dzojic H, Gustafson E, Öberg K, Giandomenico V, Essand M. A novel chromogranin-a promoter-driven
oncolytic adenovirus for midgut carcinoid therapy. Clinical Cancer Research. 2007;13:2455
Leja J, Nilsson B, Yu D, Gustafson E, Åkerström G, Öberg K, Giandomenico V, Essand M. Double-detargeted
oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability. PLoS
ONE. 2010
Lemmen JG, Arends RJ, van Boxtel AL, van der Saag PT, van der Burg B. Tissue- and time-dependent estrogen
1421.
1422.
1423.
1424.
1425.
1426.
1427.
1428.
1429.
1430.
1431.
1432.
1433.
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1435.
1436.
1437.
1438.
1439.
1440.
1441.
1442.
1443.
1444.
1445.
receptor activation in estrogen reporter mice. J Mol Endocrinol. 2004;32:689-701
Lemmen JG, Arends RJ, van der Saag PT, van der Burg B. In vivo imaging of activated estrogen receptors in utero
by estrogens and bisphenol a. Environmental Health Perspectives. 2004;112:1544-1549
Leo BM, Li X, Balian G, Anderson DG. In vivo bioluminescent imaging of virus-mediated gene transfer and
transduced cell transplantation in the intervertebral disc. Spine. 2004;29:838-844
Leonard VH, Sinn PL, Hodge G, Miest T, Devaux P, Oezguen N, Braun W, McCray PB, McChesney MB, Cattaneo R.
Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway
epithelium and is not shed. Journal of Clinical Investigation. 2008;118:2448-2458
LeRoy B, Thudi N, Nadella M, Toribio R, Tannehill Gregg S, van Bokhoven A, Davis D, Corn S, Rosol T. New bone
formation and osteolysis by a metastatic, highly invasive canine prostate carcinoma xenograft. Prostate.
2006;66:1213-1222
Leucht P, Kim JB, Amasha R, James AW, Girod S, Helms JA. Embryonic origin and hox status determine
progenitor cell fate during adult bone regeneration. Development. 2008;135:2845-2854
Levenberg S, Rouwkema J, Macdonald M, Garfein ES, Kohane DS, Darland DC, Marini R, van Blitterswijk CA,
Mulligan RC, D'Amore PA, Langer R. Engineering vascularized skeletal muscle tissue. Nat Biotechnol.
2005;23:879-884
Leveson-Gower DB, Olson JA, Sega EI, Luong RH, Baker J, Zeiser R, Negrin RS. Low doses of natural killer t cells
provide protection from acute graft-versus-host disease via an il-4-dependent mechanism. Blood.
2011;117:3220-3229
Levi B, James AW, Nelson ER, Hu S, Sun N, Peng M, Wu J, Longaker MT. Studies in adipose-derived stromal
cells: Migration and participation in repair of cranial injury after systemic injection. Plastic and reconstructive
surgery. 2011;127:1130-1140
Levi B, James AW, Nelson ER, Vistnes D, Wu B, Lee M, Gupta A, Longaker M. Human adipose derived stromal
cells heal critical size mouse calvarial defects. PLoS ONE. 2010
Levi J, De A, Cheng Z, Gambhir SS. Bisdeoxycoelenterazine derivatives for improvement of bioluminescence
resonance energy transfer assays. J Am Chem Soc. 2007;129:11900-11901
Levin C. Primer on molecular imaging technology. European Journal of Nuclear Medicine and Molecular
Imaging. 2005;32:325-345
Lewis M, Kodibagkar V, Öz O, Mason R. On the potential for molecular imaging with cerenkov luminescence.
Optics Letters. 2010;35:3889-3891
Leyton J, Lockley M, Aerts JL, Baird SK, Aboagye EO, Lemoine NR, McNeish IA. Quantifying the activity of
adenoviral e1a cr2 deletion mutants using renilla luciferase bioluminescence and 3'-deoxy-3'-[18f]
fluorothymidine positron emission tomography imaging. Cancer Res. 2006;66:9178-9185
Li B, Brown KV, Wenke JC, Guelcher SA. Sustained release of vancomycin from polyurethane scaffolds inhibits
infection of bone wounds in a rat femoral segmental defect model. Journal of controlled release : official
journal of the Controlled Release Society. 2010;145:221-230
Li C, Greenwood TR, Glunde K. Glucosamine-bound near-infrared fluorescent probes with lysosomal specificity
for breast tumor imaging. Neoplasia. 2008;10:389-398
Li C, Hirsch M, DiPrimio N, Asokan A, Goudy K, Tisch R, Samulski RJ. Cytotoxic-t-lymphocyte-mediated
elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo▿. J Virol.
2009;83:6817-6824
Li C, Li K, Yan H, Li G, Xia J, Wei X. Dextran based ph-activated near-infrared fluorescence nanoprobe imaging
the acidic compartments in cancer cells. Chemical communications. 2010;46:1326-1328
Li C, Mitchell GS, Cherry SR. Cerenkov luminescence tomography for small-animal imaging. Optics letters.
2010;35:1109-1111
Li C, Mitchell GS, Dutta J, Ahn S, Leahy RM, Cherry SR. A three-dimensional multispectral fluorescence optical
tomography imaging system for small animals based on a conical mirror design. Opt Express.
2009;17:7571-7585
Li C, Penet MF, Winnard P, Jr., Artemov D, Bhujwalla ZM. Image-guided enzyme/prodrug cancer therapy. Clin
Cancer Res. 2008;14:515-522
Li CX, Shao Y, Liu XB, Ling CC, Ng KT, Li XC, Fan ST, Lo CM, Man K. Fty720 suppresses liver tumor metastasis
by reducing the population of circulating endothelial progenitor cells, myeloid-derived suppressor cells and
regulatory t cells. Liver Transplantation. 2010;16:S141-S142
Li D, Gromov K, Soballe K, Puzas JE, O'Keefe RJ, Awad H, Drissi H, Schwarz EM. Quantitative mouse model of
implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity. J
Orthop Res. 2008;26:96-105
Li F, Cheng Q, Ling X, Stablewski A, Tang L, Foster BA, Johnson CS, Rustum YM, Porter CW. Generation of a
novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various
pathophysiological processes. Survivin expression overlaps with stem cell markers. Am J Pathol. 2010
Li F, Liu J, Jas GS, Zhang J, Qin G, Xing J, Cotes C, Zhao H, Wang X, Diaz LA, Shi ZZ, Lee DY, Li KCP, Li Z.
Synthesis and evaluation of a near-infrared fluorescent non-peptidic bivalent integrin (alpha)v(beta)3 antagonist
for cancer imaging. Bioconjugate Chemistry. 2010;21:270-278
Li F, Sonveaux P, Rabbani ZN, Liu S, Yan B, Huang Q, Vujaskovic Z, Dewhirst MW, Li CY. Regulation of hif-1α
stability through s-nitrosylation. Molecular Cell. 2007;26:63-74
1446.
1447.
1448.
1449.
1450.
1451.
1452.
1453.
1454.
1455.
1456.
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1459.
1460.
1461.
1462.
1463.
1464.
1465.
1466.
1467.
1468.
1469.
1470.
1471.
Li H-w, Li J, Helm GA, Pan D. Highly specific expression of luciferase gene in lungs of naive nude mice directed
by prostate-specific antigen promoter. Biochemical and Biophysical Research Communications.
2005;334:1287-1291
Li HJ, Everts M, Pereboeva L, Komarova S, Idan A, Curiel DT, Herschman HR. Adenovirus tumor targeting and
hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific
adapter. Cancer Res. 2007;67:5354-5361
Li HJ, Everts M, Yamamoto M, Curiel DT, Herschman HR. Combined transductional untargeting/retargeting and
transcriptional restriction enhance adenovirus gene targeting and therapy for hepatic colorectal cancer tumors.
Cancer Res. 2009;69:554
Li J, Fatima A, Komarova S, Ugai H, Uprety P, Roth JC, Wang M, Oster RA, Curiel DT, Matthews QL. Evaluation of
adenovirus capsid labeling versus transgene expression. Virol J. 2010;7:21
Li J, Li G, Gao S, Martinez C, He G, Zhou Z, Huang X, Lee JH, Zhang H, Shen Y, Wang H, Deng XW. Arabidopsis
transcription factor elongated hypocotyl5 plays a role in the feedback regulation of phytochrome a signaling.
Plant Cell. 2010;22:3634-3649
Li J, Sahagian G. Demonstration of tumor suppression by mannose 6-phosphate/insulin-like growth factor 2
receptor. Oncogene. 2004;23:9359-9368
Li JM, Newburger PE, Gounis MJ, Dargon P, Zhang X, Messina LM. Local arterial nanoparticle delivery of sirna
for nox2 knockdown to prevent restenosis in an atherosclerotic rat model. Gene Ther. 2010;17:1279-1287
Li JY, Wang H, May S, Song X, Fueyo J, Fuller GN, Wang H. Constitutive activation of c-jun n-terminal kinase
correlates with histologic grade and egfr expression in diffuse gliomas. J Neurooncol. 2008;88:11-17
Li JZ, Holman D, Li H, Liu AH, Beres B, Hankins GR, Helm GA. Long-term tracing of adenoviral expression in rat
and rabbit using luciferase imaging. J Gene Med. 2005;7:792-802
Li K, Thomasson D, Ketai L, Contag C, Pomper M, Wright M, Bray M. Potential applications of conventional and
molecular imaging to biodefense research. Clin Infect Dis. 2005;40:1471-1480
Li L, Fei Z, Ren J, Sun R, Liu Z, Sheng Z, Wang L, Sun X, Yu J, Wang Z, Fei J. Functional imaging of interleukin 1
beta expression in inflammatory process using bioluminescence imaging in transgenic mice. BMC Immunol.
2008;9:49
Li L, Zhang H, Yuan S, Tian Z, Wang L, Sun Z. Artesunate attenuates the growth of human colorectal carcinoma
and inhibits hyperactive wnt/ -catenin pathway. International Journal of Cancer. 2007;121:1360-1365
Li LS, Bey EA, Dong Y, Meng J, Patra B, Yan J, Xie XJ, Brekken RA, Barnett CC, Bornmann WG, Gao J, Boothman
DA. Modulating endogenous nqo1 levels identifies key regulatory mechanisms of action of beta-lapachone for
pancreatic cancer therapy. Clinical cancer research : an official journal of the American Association for Cancer
Research. 2011;17:275-285
Li N, Cui Z, Fang F, Lee J, Ballatori N. Heterodimerization, trafficking and membrane topology of the two
proteins, ostα and ostβ, that constitute the organic solute and steroid transporter. Biochemical Journal.
2007;407:363-372
Li S, Chen Y, Hackett M, Huang L. Tumor-targeted delivery of sirna by self-assembled nanoparticles. Molecular
Therapy. 2007;16:163-169
LI S, HUANG L. Surface-modified lpd nanoparticles for tumor targeting. Annals of the New York Academy of
Sciences. 2006;1082:1-8
Li S, Nguyen L, Xiong H, Wang M, Hu TC, She JX, Serkiz SM, Wicks GG, Dynan WS. Porous-wall hollow glass
microspheres as novel potential nanocarriers for biomedical applications. Nanomedicine : nanotechnology,
biology, and medicine. 2010;6:127-136
Li S, Tu Q, Zhang J, Stein G, Lian J, Yang PS, Chen J. Systemically transplanted bone marrow stromal cells
contributing to bone tissue regeneration. J Cell Physiol. 2008;215:204-209
Li SD, Huang L. Nanoparticles evading the reticuloendothelial system: Role of the supported bilayer. Biochimica
et Biophysica Acta. 2009;1788:2259-2266
Li W, Asokan A, Wu Z, Van Dyke T, DiPrimio N, Johnson JS, Govindaswamy L, Agbandje-McKenna M, Leichtle S,
Redmond D, McCown TJ, Petermann KB, Sharpless NE, Samulski RJ. Engineering and selection of shuffled aav
genomes: A new strategy for producing targeted biological nanoparticles. Mol Ther. 2008;16:1252-1260
Li W, Li F, Huang Q, Frederick B, Bao S, Li C. Noninvasive imaging and quantification of epidermal growth factor
receptor kinase activation in vivo. Cancer Res. 2008;68:4990
Li X, Koh AJ, Wang Z, Soki FN, Park SI, Pienta KJ, McCauley LK. Inhibitory effects of megakaryocytic cells in
prostate cancer skeletal metastasis. Journal of bone and mineral research : the official journal of the American
Society for Bone and Mineral Research. 2011;26:125-134
Li X, Liao J, Park SI, Koh AJ, Sadler WD, Pienta KJ, Rosol TJ, McCauley LK. Drugs which inhibit osteoclast
function suppress tumor growth through calcium reduction in bone. Bone. 2011;48:1354-1361
Li X, Ling W, Pennisi A, Wang Y, Khan S, Heidaran M, Pal A, Zhang X, He S, Zeitlin A, Abbot S, Faleck H, Hariri R,
Shaughnessy JD, Jr., van Rhee F, Nair B, Barlogie B, Epstein J, Yaccoby S. Human placenta-derived adherent cells
prevent bone loss, stimulate bone formation, and suppress growth of multiple myeloma in bone. Stem cells.
2011;29:263-273
Li X, Pennisi A, Zhan F, Sawyer JR, Shaughnessy JD, Yaccoby S. Establishment and exploitation of hyperdiploid
and non-hyperdiploid human myeloma cell lines. British Journal of Haematology. 2007;138:802-811
Li YS, Davidson E, Reid CN, McHale AP. Optimising ultrasound-mediated gene transfer (sonoporation) in vitro
1472.
1473.
1474.
1475.
1476.
1477.
1478.
1479.
1480.
1481.
1482.
1483.
1484.
1485.
1486.
and prolonged expression of a transgene in vivo: Potential applications for gene therapy of cancer. Cancer Lett.
2009;273:62-69
Li Z, Benghiat F, Cobbold S, Kubjak C, Schuind F, Goldman M, Moine A. Mixed chimerism induced by
vascularized bone marrow transplantation without host myeloablation. Transplantation. 2006;82:367
Li Z, Cai W, Chen X. Semiconductor quantum dots for in vivo imaging. Journal of Nanoscience and
Nanotechnology. 2007;7:2567-2581
Li Z, Huang P, Lin J, He R, Liu B, Zhang X, Yang S, Xi P, Zhang X, Ren Q, Cui D. Arginine-glycine-aspartic acidconjugated dendrimer-modified quantum dots for targeting and imaging melanoma. J Nanosci Nanotechnol.
2010;10:4859-4867
Li Z, Hulderman T, Salmen R, Chapman R, Leonard SS, Young SH, Shvedova A, Luster MI, Simeonova PP.
Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes. Environmental Health
Perspectives. 2007;115:377-382
Li Z, Lee A, Huang M, Chun H, Chung J, Chu P, Hoyt G, Yang P, Rosenberg J, Robbins RC, Wu JC. Imaging
survival and function of transplanted cardiac resident stem cells. Journal of the American College of
Cardiology. 2009;53:1229-1240
Li Z, Suzuki Y, Huang M, Cao F, Xie X, Connolly AJ, Yang PC, Wu JC. Comparison of reporter gene and iron
particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living
subjects. Stem Cells. 2008;26:864-873
Li Z, Wilson KD, Smith B, Kraft DL, Jia F, Huang M, Xie X, Robbins RC, Gambhir SS, Weissman IL, Wu JC.
Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for
treatment of myocardial infarction. PLoS One. 2009;4
Li Z, Wu JC, Sheikh AY, Kraft D, Cao F, Xie X, Patel M, Gambhir SS, Robbins RC, Cooke JP, Wu JC.
Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart
disease. Circulation. 2007;116:I46-54
Liang D, Qin Y, Zhao W, Zhai X, Guo Z, Wang R, Tong L, Lin L, Chen H, Wong YC, Zhong Z. Sallylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo
conditions. Cancer letters. 2011;310:69-76
Liang H, Ma SY, Mohammad K, Guise TA, Balian G, Shen FH. The reaction of bone to tumor growth from human
breast cancer cells in a rat spine single metastasis model. Spine. 2011;36:497-504
Liang M, Liu X, Cheng D, Liu G, Dou S, Wang Y, Rusckowski M, Hnatowich DJ. Multimodality nuclear and
fluorescence tumor imaging in mice using a streptavidin nanoparticle. Bioconjug Chem. 2010;21:1385-1388
Liang M, Liu X, Cheng D, Nakamura K, Wang Y, Dou S, Liu G, Rusckowski M, Hnatowich D. Optical antisense
tumor targeting in vivo with an improved fluorescent DNA duplex probe. Bioconjugate Chemistry.
2009;20:1223-1227
Liang X, Romo-Vivar A, Schapiro NE, Loughran P, Thorne SH, Amoscato AA, Zeh HJ, Beer-Stolz D, Lotze MT, de
Vera ME. Ethyl pyruvate administration inhibits hepatic tumor growth. J Leukoc Biol. 2009
Liang XJ, Meng H, Wang Y, He H, Meng J, Lu J, Wang PC, Zhao Y, Gao X, Sun B, Chen C, Xing G, Shen D,
Gottesman MM, Wu Y, Yin J, Jia L. Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by
reactivating endocytosis. Proceedings of the National Academy of Sciences of the United States of America.
2010;107:7449-7454
Liang Y, Liu C, Djeu J, Zhong B, Peters T, Scharffetter-Kochanek K, Anasetti C, Yu X. $# x003b2; 2 integrins
separate graft-versus-host disease and graft-versus-leukemia effects. Blood. 2008;111:954
... Animals that received A920-luc/neo were given intraperitoneal (150 mg/kg) D-Luciferin
(Xenogen, Alameda, CA). At 910 minutes after injection, mice were anesthetized with
isofluorane and placed supine in the Xenogen IVIS bioluminescence ...
1487.
Liang Y, Liu C, Djeu JY, Zhong B, Peters T, Scharffetter-Kochanek K, Anasetti C, Yu XZ. Beta2 integrins separate
graft-versus-host disease and graft-versus-leukemia effects. Blood. 2008;111:954-962
1488.
Liang Y, Liu C, Djeu JY, Zhong B, Peters T, Scharffetter-Kochanek K, Anasetti C, Yu XZ. Β2 integrins separate
graft-versus-host disease and graft-versus-leukemia effects. Blood. 2008;111:954-962
1489.
Liang Z, Brooks J, Willard M, Liang K, Yoon Y, Kang S, Shim H. Cxcr4/cxcl12 axis promotes vegf-mediated
tumor angiogenesis through akt signaling pathway. Biochemical and Biophysical Research Communications.
2007;359:716-722
1490.
Liao A, McMahon M, London C. Characterization, expression and function of c met in canine spontaneous
cancers. Veterinary and Comparative Oncology. 2005;3:49
1491.
Liao CG, Kong LM, Song F, Xing JL, Wang LX, Sun ZJ, Tang H, Yao H, Zhang Y, Wang L, Wang Y, Yang XM, Li Y,
Chen ZN. Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular
carcinoma proliferation and invasion. Molecular and cellular biology. 2011;31:2591-2604
1492.
Liao CP, Zhong C, Saribekyan G, Bading J, Park R, Conti PS, Moats R, Berns A, Shi W, Zhou Z, Nikitin AY, RoyBurman P. Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis
by bioluminescence or fluorescence. Cancer Res. 2007;67:7525-7533
1493.
Liao J, Schneider A, Datta N, McCauley L. Extracellular calcium as a candidate mediator of prostate cancer skeletal
metastasis. Cancer Res. 2006;66:9065
1494.
Libani IV, Lucignani G, Gianelli U, Degrassi A, Russo M, Bosari S, Clerici M, Ottobrini L. Labeling protocols for
1495.
1496.
1497.
1498.
1499.
1500.
1501.
1502.
1503.
1504.
1505.
1506.
1507.
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1509.
1510.
1511.
1512.
1513.
1514.
1515.
1516.
1517.
1518.
1519.
in vivo tracking of human skeletal muscle cells (hskmcs) by magnetic resonance and bioluminescence imaging.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2011
Lien CY, Chih-Yuan Ho K, Lee OK, Blunn GW, Su Y. Restoration of bone mass and strength in glucocorticoidtreated mice by systemic transplantation of cxcr4 and cbfa-1 co-expressing mesenchymal stem cells. J Bone
Miner Res. 2009;24:837-848
Lillehammer T, Tveito S, Engesaeter B, Fodstad O, Maelandsmo G, Engebraaten O. Melanoma-specific expression
in first-generation adenoviral vectors in vitro and in vivo—use of the human tyrosinase promoter with human
enhancers. Cancer Gene Therapy. 2005;12:864-872
Lim C-K, Lee Y-D, Na J, Oh JM, Her S, Kim K, Choi K, Kim S, Kwon IC. Chemiluminescence-generating
nanoreactor formulation for near-infrared imaging of hydrogen peroxide and glucose level in vivo. Advanced
Functional Materials. 2010;20:2644-2648
Lim E, Modi K, Christensen A, Meganck J, Oldfield S, Zhang N. Monitoring tumor metastases and osteolytic
lesions with bioluminescence and micro ct imaging. J Vis Exp. 2011:e2775
Limberis MP, Bell CL, Heath J, Wilson JM. Activation of transgene-specific t cells following lentivirus-mediated
gene delivery to mouse lung. Mol Ther. 2010;18:143-150
Lin A, Hokugo A, Choi J, Nishimura I. Small cytoskeleton-associated molecule, fibroblast growth factor receptor
1 oncogene partner 2/wound inducible transcript-3.0 (fgfr1op2/wit3.0), facilitates fibroblast-driven wound
closure. Am J Pathol. 2010;176:108-121
Lin AH, Luo J, Mondshein LH, ten Dijke P, Vivien D, Contag CH, Wyss-Coray T. Global analysis of smad2/3dependent tgf-{beta} signaling in living mice reveals prominent tissue-specific responses to injury. J Immunol.
2005;175:547-554
Lin E, Wang Q, Swenson S, Jadvar H, Groshen S, Ye W, Markland F, Pinski J. The disintegrin contortrostatin in
combination with docetaxel is a potent inhibitor of prostate cancer in vitro and in vivo. Prostate.
2010;70:1359-1370
Lin J, Lalani AS, Harding TC, Gonzalez M, Wu W-W, Luan B, Tu GH, Koprivnikar K, VanRoey MJ, He Y, Alitalo K,
Jooss K. Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a
soluble vegfr-3 decoy receptor. Cancer Res. 2005;65:6901-6909
Lin J, Li B, Rimmer E, VanRoey M, Jooss K. Enhancement of the anti-tumor efficacy of a gm-csf-secreting tumor
cell immunotherapy in preclinical models by cytosine arabinoside. Experimental Hematology. 2008;36:319-328
Lin KY, Lu D, Hung CF, Peng S, Huang L, Jie C, Murillo F, Rowley J, Tsai YC, He L, Kim DJ, Jaffee E, Pardoll D,
Wu TC. Ectopic expression of vascular cell adhesion molecule-1 as a new mechanism for tumor immune evasion.
Cancer Res. 2007;67:1832-1841
Lin LC, Hsu JH, Wang LC. Identification of novel inhibitors of 1-aminocyclopropane-1-carboxylic acid synthase
by chemical screening in arabidopsis thaliana. J Biol Chem. 2010;285:33445-33456
Lin M, Marti G, Dieb R, Wang J, Ferguson M, Qaiser R, Bonde P, Duncan M, Harmon J. Delivery of plasmid DNA
expression vector for keratinocyte growth factor-1 using electroporation to improve cutaneous wound healing in
a septic rat model. Wound Repair and Regeneration. 2006;14:618-624
Lin M, Marti G, Dieb R, Wang J, Qaiser R, Bonde P, Duncan M, Harmon J. Electroporation improves transfection
efficiency in rat wound healing model. Journal of the American College of Surgeons. 2004;199:58-59
Lin SF, Price DL, Chen CH, Brader P, Li S, Gonzalez L, Zhang Q, Yu YA, Chen N, Szalay AA, Fong Y, Wong RJ.
Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo. J Clin Endocrinol Metab.
2008;93:4403-4407
Lin SF, Yu Z, Riedl C, Woo Y, Zhang Q, Yu YA, Timiryasova T, Chen N, Shah JP, Szalay AA, Fong Y, Wong RJ.
Treatment of anaplastic thyroid carcinoma in vitro with a mutant vaccinia virus. Surgery. 2007;142:976-983;
discussion 976-983
Lin Y, Molter J, Lee Z, Gerson SL. Bioluminescence imaging of hematopoietic stem cell repopulation in murine
models. Methods Mol Biol. 2008;430:295-306
Linehan JL, Tian X, Morris JK, Kaufman DS. Improved analysis of hematopoietic engraftment by non-invasive in
vivo bioluminescent imaging of transplanted human embryonic stem cell-derived hematopoietic cells. Blood.
2005;106:370A
Ling X, Konopleva M, Zeng Z, Ruvolo V, Stephens LC, Schober W, McQueen T, Dietrich M, Madden TL, Andreeff
M. The novel triterpenoid c-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic
murine breast tumor growth through inactivation of stat3 signaling. Cancer Res. 2007;67:4210-4218
Ling X, Marini F, Konopleva M, Schober W, Shi Y, Burks J, Clise-Dwyer K, Wang R, Zhang W, Yuan X.
Mesenchymal stem cells overexpressing ifn- inhibit breast cancer growth and metastases through stat3 signaling
in a syngeneic tumor model. Cancer Microenvironment. 2010;3:1-13
Lipshutz GS, Gruber CA, Cao Y, Hardy J, Contag CH, Gaensler KM. In utero delivery of adeno-associated viral
vectors: Intraperitoneal gene transfer produces long-term expression. Molecular Therapy. 2001;3:284-292
Lipshutz GS, Titre D, Brindle M, Bisconte AR, Contag CH, Gaensler KM. Comparison of gene expression after
intraperitoneal delivery of aav2 or aav5 in utero. Mol Ther. 2003;8:90-98
Lisman R. Lecture-challenges in aesthetic eyelid restoration: Re-operations, retractions and ptosis. Plastic and
Reconstructive Surgery. 2006;118:71
listed Na. Purines 2008 meeting 29 june – 2 july 2008, copenhagen, denmark. Purinergic Signal. 2008;4:1-210
Liu C, Yu S, Kappes J, Wang J, Grizzle WE, Zinn KR, Zhang HG. Expansion of spleen myeloid suppressor cells
1520.
1521.
1522.
1523.
1524.
1525.
1526.
1527.
1528.
1529.
1530.
1531.
1532.
1533.
1534.
1535.
1536.
1537.
1538.
1539.
1540.
1541.
1542.
1543.
1544.
represses nk cell cytotoxicity in tumor-bearing host. Blood. 2007;109:4336-4342
Liu CC, Pearson C, Bu G. Cooperative folding and ligand-binding properties of lrp6 β-propeller domains*.
Journal of Biological Chemistry. 2009;284:15299-15307
Liu CC, Prior J, Piwnica-Worms D, Bu G. Lrp6 overexpression defines a class of breast cancer subtype and is a
target for therapy. Proceedings of the National Academy of Sciences of the United States of America.
2010;107:5136-5141
Liu F, Sag D, Wang J, Shollenberger LM, Niu F, Yuan X, Li SD, Thompson M, Monahan P. Sine-wave current for
efficient and safe in vivo gene transfer. Mol Ther. 2007;15:1842-1847
Liu H, Ren G, Miao Z, Zhang X, Tang X, Han P, Gambhir SS, Cheng Z. Molecular optical imaging with radioactive
probes. PLoS One. 2010;5:e9470
Liu H, Zhang X, Xing B, Han P, Gambhir SS, Cheng Z. Radiation-luminescence-excited quantum dots for in vivo
multiplexed optical imaging. Small. 2010;6:1087-1091
Liu J, Arends R, Martens A, den Brok-Bardoel MH, Scheepers MG, van Blitterswijk CA, de Boer J. Noninvasive
imaging of bone-specific collagen i expression in a luciferase transgenic mouse model. Tissue Eng Part C
Methods. 2010
Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L. Pdgf-d
improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by
activating cxcr4 in breast cancer. Clinical cancer research : an official journal of the American Association for
Cancer Research. 2011;17:3638-3648
Liu J, Zhang N, Li Q, Zhang W, Ke F, Leng Q, Wang H, Chen J. Tumor-associated macrophages recruit ccr6+
regulatory t cells and promote the development of colorectal cancer via enhancing ccl20 production in mice.
PloS one. 2011;6:e19495
Liu L, Hastings JW. Two different domains of the luciferase gene in the heterotrophic dinoflagellate noctiluca
scintillans occur as two separate genes in photosynthetic species. Proceedings of the National Academy of
Sciences of the United States of America. 2007;104:696-701
Liu L, Marti GP, Wei X, Zhang X, Zhang H, Liu YV, Nastai M, Semenza GL, Harmon JW. Age-dependent impairment
of hif-1α ̣expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound
healing, angiogenesis, and circulating angiogenic cells. Journal of Cellular Physiology. 2008;217:319-327
Liu L, Mason RP. Imaging beta-galactosidase activity in human tumor xenografts and transgenic mice using a
chemiluminescent substrate. PLoS One. 2010;5
Liu L, O'Conner P, Cotter PD, Hill C, Ross RP. Controlling listeria monocytogenes in cottage cheese through
heterologous production of enterocin a by lactococcus lactis. J Appl Microbiol. 2008;104:1059-1066
Liu S, Li S, Du Y. Polychlorinated biphenyls (pcbs) enhance metastatic properties of breast cancer cells by
activating rho-associated kinase (rock). PLoS One. 2010;5
Liu S, Wang H, Yang Z, Kon T, Zhu J, Cao Y, Li F, Kirkpatrick J, Nicchitta CV, Li C-Y. Enhancement of cancer
radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression.
Cancer Res. 2005;65:9126-9131
Liu TC, Thorne SH, Kirn DH. Oncolytic adenoviruses for cancer gene therapy. Methods Mol Biol.
2008;433:243-258
Liu W, Owen DP, Fisher KD, Seymour LW, Stevenson M. Establishment of a positive-readout reporter system for
sirnas. J RNAi Gene Silencing. 2009;5:331-338
Liu WF, Ma M, Bratlie KM, Dang TT, Langer R, Anderson DG. Real-time in vivo detection of biomaterial-induced
reactive oxygen species. Biomaterials. 2010
Liu X, Wang Y, Nakamura K, Liu G, Dou S, Kubo A, Rusckowski M, Hnatowich DJ. Optical antisense imaging of
tumor with fluorescent DNA duplexes. Bioconjug Chem. 2007;18:1905-1911
Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, 3rd, Olefsky J,
Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator
exchange. Nature. 2008;456:269-273
Liu Y, Kon T, Li C, Zhong P. High intensity focused ultrasound-induced gene activation in solid tumors. Journal
of the Acoustical Society of America. 2006;120:492-501
Liu Y, Wang H, Kamei K, Yan M, Chen KJ, Yuan Q, Shi L, Lu Y, Tseng HR. Delivery of intact transcription factor
by using self-assembled supramolecular nanoparticles. Angewandte Chemie. 2011;50:3058-3062
Liu Y, Zhang W, Cheung L, Wu Q, Li C, Rosenblum M. The anti-gp240 fusion toxin scfvmel/tnf shows potent
antitumor activity and synergy with chemotherapeutic agents. Proceedings of the American Association for
Cancer Research. 2005;2005:162
Liu Y, Zhang W, Cheung LH, Niu T, Wu Q, Li C, Van Pelt CS, Rosenblum MG. The antimelanoma immunocytokine
scfvmel/tnf shows reduced toxicity and potent antitumor activity against human tumor xe nog rafts1. Neoplasia.
2006;8:384-393
Ljubimova JY, Fujita M, Khazenzon NM, Lee BS, Wachsmann-Hogiu S, Farkas DL, Black KL, Holler E.
Nanoconjugate based on polymalic acid for tumor targeting. Chemico-Biological Interactions.
2008;171:195-203
Ljubimova JY, Fujita M, Ljubimov AV, Torchilin VP, Black KL, Holler E. Poly(malic acid) nanoconjugates
containing various antibodies and oligonucleotides for multitargeting drug delivery. Nanomedicine (Lond).
2008;3:247-265
1545.
1546.
1547.
1548.
1549.
1550.
1551.
1552.
1553.
1554.
1555.
1556.
1557.
1558.
1559.
1560.
1561.
1562.
1563.
1564.
1565.
1566.
1567.
1568.
1569.
1570.
1571.
Lo HR, Lin JH, Chen YH, Chen CL, Shao CP, Lai YC, Hor LI. Rtx toxin enhances the survival of vibrio vulnificus
during infection by protecting the organism from phagocytosis. The Journal of infectious diseases.
2011;203:1866-1874
Lo WC, Chiou JF, Gelovani JG, Cheong ML, Lee CM, Liu HY, Wu CH, Wang MF, Lin CT, Deng WP.
Transplantation of embryonic fibroblasts treated with platelet-rich plasma induces osteogenesis in samp8 mice
monitored by molecular imaging. J Nucl Med. 2009;50:765-773
Loayza-Puch F, Yoshida Y, Matsuzaki T, Takahashi C, Kitayama H, Noda M. Hypoxia and ras-signaling pathways
converge on, and cooperatively downregulate, the reck tumor-suppressor protein through micrornas. Oncogene.
2010
Lobbestael E, Reumers V, Ibrahimi A, Paesen K, Thiry I, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V,
Taymans JM. Immunohistochemical detection of transgene expression in the brain using small epitope tags.
BMC Biotechnol. 2010;10:16
Loberg RD, Day LL, Dunn R, Kalikin LM, Pienta KJ. Inhibition of decay-accelerating factor (cd55) attenuates
prostate cancer growth and survival in vivo1. Neoplasia. 2006;8:69-78
Lockley M, Fernandez M, Wang Y, Li NF, Conroy S, Lemoine N, McNeish I. Activity of the adenoviral e1a
deletion mutant dl922-947 in ovarian cancer: Comparison with e1a wild-type viruses, bioluminescence
monitoring, and intraperitoneal delivery in icodextrin. Cancer Res. 2006;66:989-998
Loeffler M, Le'Negrate G, Krajewska M, Reed JC. Attenuated salmonella engineered to produce human cytokine
light inhibit tumor growth. Proceedings of the National Academy of Sciences of the United States of America.
2007;104:12879-12883
Loening AM, Dragulescu-Andrasi A, Gambhir SS. A red-shifted renilla luciferase for transient reporter-gene
expression. Nat Methods. 2010;7:5-6
Loening AM, Wu AM, Gambhir SS. Red-shifted renilla reniformis luciferase variants for imaging in living
subjects. Nat Methods. 2007;4:641-643
Loessner H, Endmann A, Leschner S, Westphal K, Rohde M, Miloud T, Hämmerling G, Neuhaus K, Weiss S.
Remote control of tumour targeted salmonella enterica serovar typhimurium by the use of l arabinose as inducer
of bacterial gene expression in vivo. Cellular Microbiology. 2007;9:1529-1537
Loessner H, Leschner S, Endmann A, Westphal K, Wolf K, Kochruebe K, Miloud T, Altenbuchner J, Weiss S. Druginducible remote control of gene expression by probiotic escherichia coli nissle 1917 in intestine, tumor and
gall bladder of mice. Microbes and Infection. 2009;11:1097-1105
Lok C. Picture perfect. Nature. 2001;412:372-374
Lora JM, Zhang DM, Liao SM, Burwell T, King AM, Barker PA, Singh L, Keaveney M, Morgenstern J, GutierrezRamos JC, Coyle AJ, Fraser CC. Tumor necrosis factor-alpha triggers mucus production in airway epithelium
through an ikappab kinase beta-dependent mechanism. J Biol Chem. 2005;280:36510-36517
Lorf T, Sablinski T, Ringe B, Sachs DH. Porcine to monkey kidney xenotransplantation. Langenbecks Archiv fur
Chirurgie. 1996:567-570
Lorger M, Krueger JS, O'Neal M, Staflin K, Felding-Habermann B. Activation of tumor cell integrin αvβ3 controls
angiogenesis and metastatic growth in the brain. Proceedings of the National Academy of Sciences of the United
States of America. 2009;106:10666-10671
Loudovaris T, Mariana L, Jhala G, Sanders N, Kay TWH. Pre-implantation of cell encapsulation devices allows for
greater survival of transplanted cells. Xenotransplantation. 2009;16:407
Louie A. Multimodality imaging probes: Design and challenges. Chemical Reviews. 2010;110:3146-3195
Love Z, Wang F, Dennis J, Awadallah A, Salem N, Lin Y, Weisenberger A, Majewski S, Gerson S, Lee Z. Imaging of
mesenchymal stem cell transplant by bioluminescence and pet. J Nucl Med. 2007;48:2011-2020
Loving CL, Khurana T, Osorio M, Lee GM, Kelly VK, Stibitz S, Merkel TJ. Role of anthrax toxins in
dissemination, disease progression, and induction of protective adaptive immunity in the mouse aerosol
challenge model▿†. Infection and Immunity. 2009;77:255-265
Lowik CW, Kaijzel EL, Que I, Van der Pluijm G, Kok P, Lelieveldt BP, Dijkstra J. Non-invasive 3d multi-modality
imaging of tumor progression and osteolytic bone metastases in mouse models of cancer. Bone (New York).
2007;40:S230
Lu C, Kamat A, Lin Y, Merritt W, Landen C, Kim T, Spannuth W, Arumugam T, Han L, Jennings N. Dual targeting
of endothelial cells and pericytes in antivascular therapy for ovarian carcinoma. Clinical Cancer Research.
2007;13:4209
Lu D, Hoory T, Monie A, Wu A, Wang MC, Hung CF. Treatment with demethylating agent, 5-aza-2’-deoxycytidine
enhances therapeutic hpv DNA vaccine potency. Vaccine. 2009;27:4363-4369
Lu RM, Chang YL, Chen MS, Wu HC. Single chain anti-c-met antibody conjugated nanoparticles for in vivo
tumor-targeted imaging and drug delivery. Biomaterials. 2011;32:3265-3274
Lu X, Kang Y. Organotropism of breast cancer metastasis. J Mammary Gland Biol Neoplasia. 2007;12:153-162
Lu X, Kang Y. Chemokine (c-c motif) ligand 2 engages ccr2+ stromal cells of monocytic origin to promote breast
cancer metastasis to lung and bone*. Journal of Biological Chemistry. 2009;284:29087-29096
Lu X, Kang Y. Efficient acquisition of dual metastasis organotropism to bone and lung through stable
spontaneous fusion between mda-mb-231 variants. Proceedings of the National Academy of Sciences of the
United States of America. 2009;106:9385-9390
Lu X, Sankin G, Pua EC, Madden J, Zhong P. Activation of transgene expression in skeletal muscle by focused
1572.
1573.
1574.
1575.
1576.
1577.
1578.
1579.
1580.
1581.
1582.
1583.
1584.
1585.
1586.
1587.
1588.
1589.
1590.
1591.
1592.
1593.
1594.
1595.
1596.
1597.
1598.
ultrasound. Biochemical and Biophysical Research Communications. 2009;379:428-433
Lu X, Wang Q, Hu G, Van Poznak C, Fleisher M, Reiss M, Massagué J, Kang Y. Adamts1 and mmp1 proteolytically
engage egf-like ligands in an osteolytic signaling cascade for bone metastasis. Genes and Development.
2009;23:1882-1894
Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J,
Kaufman DL. Bioluminescent monitoring of islet graft survival after transplantation. Mol Ther. 2004;9:428-435
Lu Y, Kashida Y, Kulp S, Wang Y, Wang D, Hung J, Tang M, Lin Z, Chen T, Cheng A. Efficacy of a novel histone
deacetylase inhibitor in murine models of hepatocellular carcinoma. Hepatology. 2007;46:1119-1130
Luker G. Special conference of the american association for cancer research on molecular imaging in cancer.
Cancer Res. 2002;62:2195
Luker GD, Bardill JP, Prior JL, Pica CM, Piwnica-Worms D, Leib DA. Noninvasive bioluminescence imaging of
herpes simplex virus type 1 infection and therapy in living mice. J Virol. 2002;76:12149-12161
Luker GD, Leib DA. Luciferase real-time bioluminescence imaging for the study of viral pathogenesis. DNA
viruses. 2004:285-294.
Luker GD, Leib DA. Luciferase real-time bioluminescence imaging for the study of viral pathogenesis. Methods
Mol Biol. 2005;292:285-296
Luker GD, Luker KE. Optical imaging: Current applications and future directions. J Nucl Med. 2008;49:1-4
Luker GD, Pica CM, Song J, Luker KE, Piwnica-Worms D. Imaging 26s proteasome activity and inhibition in
living mice. Nat Med. 2003;9:969-973
Luker GD, Prior JL, Song J, Pica CM, Leib DA. Bioluminescence imaging reveals systemic dissemination of
herpes simplex virus type 1 in the absence of interferon receptors. J Virol. 2003;77:11082-11093
Luker KE, Gupta M, Luker GD. Imaging chemokine receptor dimerization with firefly luciferase complementation.
Faseb J. 2009;23:823-834
Luker KE, Luker GD. Functions of cxcl12 and cxcr4 in breast cancer. Cancer Lett. 2006;238:30-41
Luker KE, Luker GD. Applications of bioluminescence imaging to antiviral research and therapy: Multiple
luciferase enzymes and quantitation. Antiviral Res. 2008;78:179-187
Luker KE, Schultz T, Romine J, Leib DA, Luker GD. Transgenic reporter mouse for bioluminescence imaging of
herpes simplex virus 1 infection in living mice. Virology. 2006;347:286-295
Luker KE, Smith MCP, Luker GD, Gammon ST, Piwnica-Worms H, Piwnica-Worms D. Kinetics of regulated
protein–protein interactions revealed with firefly luciferase complementation imaging in cells and living
an imals . Pr o ceed in g s o f th e Na tio n a l Aca d emy o f S cien ces o f th e Un ited S ta tes o f Amer ica .
2004;101:12288-12293
Lun X, Alain T, Zemp FJ, Zhou H, Rahman MM, Hamilton MG, McFadden G, Bell J, Senger DL, Forsyth PA.
Myxoma virus virotherapy for glioma in immunocompetent animal models: Optimizing administration routes
and synergy with rapamycin. Cancer Res. 2010;70:598-608
Lun X, Chan J, Zhou H, Sun B, Kelly JJ, Stechishin OO, Bell JC, Parato K, Hu K, Vaillant D, Wang J, Liu TC,
Breitbach C, Kirn D, Senger DL, Forsyth PA. Efficacy and safety/toxicity study of recombinant vaccinia virus
jx-594 in two immunocompetent animal models of glioma. Molecular therapy : the journal of the American
Society of Gene Therapy. 2010;18:1927-1936
Lundqvist A, Su S, Rao S, Childs R. Cutting edge: Bortezomib-treated tumors sensitized to nk cell apoptosis
paradoxically acquire resistance to antigen-specific t cells. J Immunol. 2010;184:1139-1142
Lundqvist A, Yokoyama H, Smith A, Berg M, Childs R. Bortezomib treatment and regulatory t-cell depletion
enhance the antitumor effects of adoptively infused nk cells. Blood. 2009;113:6120-6127
Luo J, Ho P, Steinman L, Wyss-Coray T. Bioluminescence in vivo imaging of autoimmune encephalomyelitis
predicts disease. J Neuroinflammation. 2008;5:6
Luo J, Ho PP, Buckwalter MS, Hsu T, Lee LY, Zhang H, Kim DK, Kim SJ, Gambhir SS, Steinman L, Wyss-Coray T.
Glia-dependent tgf-beta signaling, acting independently of the th17 pathway, is critical for initiation of murine
autoimmune encephalomyelitis. J Clin Invest. 2007;117:3306-3315
Luo J, Lin AH, Masliah E, Wyss-Coray T. Bioluminescence imaging of smad signaling in living mice shows
correlation with excitotoxic neurodegeneration. Proceedings of the National Academy of Sciences of the United
States of America. 2006;103:18326-18331
Luo J, Wyss-Coray T. Bioluminescence analysis of smad-dependent tgf-? Signaling in live mice.
Bioluminescence. 2009:193-202.
Luo X, Chen J, Song WX, Tang N, Luo J, Deng ZL, Sharff KA, He G, Bi Y, He BC, Bennett E, Huang J, Kang Q, Jiang
W, Su Y, Zhu GH, Yin H, He Y, Wang Y, Souris JS, Chen L, Zuo GW, Montag AG, Reid RR, Haydon RC, Luu HH, He
TC. Osteogenic bmps promote tumor growth of human osteosarcomas that harbor differentiation defects. Lab
Invest. 2008;88:1264-1277
Lye LF, Owens K, Shi H, Murta SMF, Vieira AC, Turco SJ, Tschudi C, Ullu E, Beverley SM. Retention and loss of
rna interference pathways in trypanosomatid protozoans. PLoS Pathog. 2010;6
Lyons S, Clermont A, Neben T, Campbell K, Coffee R, Hunter J, Purchio T, Jenkins D. Non-invasive in vivo
bioluminescent imaging of tumor angiogenesis in mice. Proceedings of the American Association for Cancer
Research. 2005;2005:903
Lyons S, Lim E, Clermont A, Dusich J, Neben T, Campbell K, Coffee R, Grass D, Purchio T, Jenkins D. Tissuespecific regulation of luciferase expression enables bioluminescence imaging of oncogene induced
1599.
1600.
1601.
1602.
1603.
1604.
1605.
1606.
1607.
1608.
1609.
1610.
1611.
1612.
1613.
1614.
1615.
1616.
1617.
1618.
1619.
1620.
1621.
1622.
1623.
1624.
tumorigenesis in the pancreas and bladder of mice. Proceedings of the American Association for Cancer
Research. 2006;2006:813
Lyons SK. Advances in imaging mouse tumour models in vivo. Journal of Pathology. 2005;205:194-205
Lyons SK, Lim E, Clermont AO, Dusich J, Zhu L, Campbell KD, Coffee RJ, Grass DS, Hunter J, Purchio T, Jenkins
D. Noninvasive bioluminescence imaging of normal and spontaneously transformed prostate tissue in mice.
Cancer Res. 2006;66:4701-4707
Lyons SK, Meuwissen R, Krimpenfort P, Berns A. The generation of a conditional reporter that enables
bioluminescence imaging of cre/loxp-dependent tumorigenesis in mice. Cancer Res. 2003;63:7042-7046
MA C. Animal models. Modern drug discovery. 2004
Ma C. Animal models of disease. Modern drug discovery. 2004;7
Ma C, Rong Y, Radiloff DR, Datto MB, Centeno B, Bao S, Cheng AWM, Lin F, Jiang S, Yeatman TJ, Wang XF.
Extracellular matrix protein βig-h3/tgfbi promotes metastasis of colon cancer by enhancing cell extravasation.
Genes and Development. 2008;22:308-321
Ma L, Xiang Z, Sherrill TP, Wang L, Blackwell TS, Williams P, Chong A, Chari R, Yin D. Bioluminescence imaging
(bli) visualizes activation of nf-κb in mouse cardiac transplantation. Transplantation. 2008;85:903-910
Ma L, Xiang Z, Sherrill TP, Wang L, Blackwell TS, Williams P, Chong A, Chari R, Yin DP. Bioluminescence
imaging visualizes activation of nuclear factor-kappab in mouse cardiac transplantation. Transplantation.
2008;85:903-910
Ma L, Yu P, Veerendra B, Rold T, Retzloff L, Prasanphanich A, Sieckman G, Hoffman T, Volkert W, Smith C. In
vitro and in vivo evaluation of alexa fluor 680-bombesin [7-14] nh~ 2 peptide conjugate, a high-affinity
fluorescent probe with high selectivity for the gastrin-releasing peptide receptor. Molecular Imaging.
2007;6:171-180
Ma LL, Gao X, Liu L, Xiang Z, Blackwell TS, Williams P, Chari RS, Yin DP. Cpg odn triggers liver inflmmatory
reaction and abrogates spontaneous tolerance*. Liver Transpl. 2009;15:915
Ma MS, Van Dam G, Meek M, Boddeke E, Copray S. In vivo bioluminescent imaging of schwann cells in a poly
(dl-lactide-epsilon-caprolactone) nerve guide. Muscle Nerve. 2009
Ma N, Marshall AF, Rao J. Near-infrared light emitting luciferase via biomineralization. J Am Chem Soc.
2010;132:6884-6885
Ma Y, Hu H, Berrebi AS, Mathers PH, Agmon A. Distinct subtypes of somatostatin-containing neocortical
interneurons revealed in transgenic mice. Journal of Neuroscience. 2006;26:5069-5082
Ma Y, Zhao S, Zhu J, Bettano KA, Qu X, Marshall CG, Young JR, Kohl NE, Scott ML, Zhang W, Wang Y. Real-time
bioluminescence imaging of polycythemia vera development in mice. Biochim Biophys Acta. 2009
Mackanos MA, Helms M, Kalish F, Contag CH. Image-guided genomic analysis of tissue response to laserinduced thermal stress. Journal of biomedical optics. 2011;16:058001
Madeira da Silva L, Owens KL, Murta SMF, Beverley SM. Regulated expression of the leishmania major surface
virulence factor lipophosphoglycan using conditionally destabilized fusion proteins. Proceedings of the
National Academy of Sciences of the United States of America. 2009;106:7583-7588
Mader EK, Maeyama Y, Lin Y, Butler GW, Russell HM, Galanis E, Russell SJ, Dietz AB, Peng KW. Mesenchymal
stem cell carriers protect oncolytic measles viruses from antibody neutralization in an orthotopic ovarian cancer
therapy model. Clin Cancer Res. 2009;15:7246-7255
Maes W, Deroose C, Reumers V, Krylyshkina O, Gijsbers R, Baekelandt V, Ceuppens J, Debyser Z, Van Gool SW.
In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy
against malignant glioma. J Neurooncol. 2009;91:127-139
Makino A, Harada H, Okada T, Kimura H, Amano H, Saji H, Hiraoka M, Kimura S. Effective encapsulation of a new
cationic gadolinium chelate into apoferritin and its evaluation as an mri contrast agent. Nanomedicine :
nanotechnology, biology, and medicine. 2011
Makino A, Kimura S. Preparation of peptide- and protein-based molecular assemblies and their utilizations as
nanocarriers for tumor imaging. Reactive and Functional Polymers. 2011;71:272-279
Makino A, Kizaka-Kondoh S, Yamahara R, Hara I, Kanzaki T, Ozeki E, Hiraoka M, Kimura S. Near-infrared
fluorescence tumor imaging using nanocarrier composed of poly(l-lactic acid)-block-poly(sarcosine)
amphiphilic polydepsipeptide. Biomaterials. 2009;30:5156-5160
Maksimow M, Miiluniemi M, Marttila-Ichihara F, Jalkanen S, Hanninen A. Antigen targeting to endosomal
pathway in dendritic cell vaccination activates regulatory t cells and attenuates tumor immunity. Blood.
2006;108:1298
Malboeuf C, Simon D, Lee Y, Lankes H, Dewhurst S, Frelinger J, Rose R. Human papillomavirus-like particles
mediate functional delivery of plasmid DNA to antigen presenting cells in vivo. Vaccine. 2007;25:3270-3276
Malla R, Gopinath S, Alapati K, Gondi CS, Gujrati M, Dinh DH, Mohanam S, Rao JS. Downregulation of upar and
cathepsin b induces apoptosis via regulation of bcl-2 and bax and inhibition of the pi3k/akt pathway in gliomas.
PloS one. 2010;5:e13731
Malley R, Henneke P, Morse SC, Cieslewicz MJ, Lipsitch M, Thompson CM, Kurt-Jones E, Paton JC, Wessels MR,
Golenbock DT. Recognition of pneumolysin by toll-like receptor 4 confers resistance to pneumococcal infection.
Proceedings of the National Academy of Sciences of the United States of America. 2003;100:1966-1971
Malstrom S, Tili E, Kappes D, Ceci JD, Tsichlis PN. Tumor induction by an lck-myrakt transgene is delayed by
mechanisms controlling the size of the thymus. Proceedings of the National Academy of Sciences of the United
1625.
1626.
1627.
1628.
1629.
1630.
1631.
1632.
1633.
1634.
1635.
1636.
1637.
1638.
1639.
1640.
1641.
1642.
1643.
1644.
1645.
1646.
1647.
1648.
States of America. 2001;98:14967-14972
Malstrom SE, Jekic-McMullen D, Sambucetti L, Ang A, Reeves R, Purchio AF, Contag PR, West DB. In vivo
bioluminescent monitoring of chemical toxicity using heme oxygenase-luciferase transgenic mice. Toxicology
and Applied Pharmacology. 2004;200:219-228
Malstrom SE, Tornavaca O, Meseguer A, Purchio AF, West DB. The characterization and hormonal regulation of
kidney androgen-regulated protein (kap)-luciferase transgenic mice. Toxicological Sciences. 2004;79:266-277
Man K, Cheng Q, Lam T-T, Ng KT, Liu X-B, Fan S-T. Acute phase inflammatory response promotes liver tumor
recurrence and metastasis by mobilization of circulating epcs and activation of tams. Proceedings of the
American Association for Cancer Research Annual Meeting. 2009;50:770-771
Man K, Ng KT, Xu A, Cheng Q, Lo CM, Xiao JW, Sun BS, Lim ZX, Cheung JS, Wu EX, Sun CK, Poon RT, Fan ST.
Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor
angiogenesis and downregulation of rho kinase/ifn-inducible protein 10/matrix metalloproteinase 9 signaling.
Clin Cancer Res. 2010;16:967-977
Man K, Ng KTP, Liu XB, Yeung OWH, Lo C-M, Fan S-T. Inflammatory microenvironment accelerates liver tumor
growth and metastasis by mobilizing circulating endothelial progenitor cells and increasing cancer stem like cell
populations. Proceedings of the American Association for Cancer Research Annual Meeting. 2010;51:321
Mancardi DA, Jonsson F, Iannascoli B, Khun H, Van Rooijen N, Huerre M, Daeron M, Bruhns P. The murine highaffinity igg receptor fcgammariv is sufficient for autoantibody-induced arthritis. Journal of immunology.
2011;186:1899-1903
Mandl S, Schimmelpfennig C, Edinger M, Negrin RS, Contag CH. Understanding immune cell trafficking patterns
via in vivo bioluminescence imaging. J Cell Biochem Suppl. 2002;39:239-248
Mandl SJ, Mari C, Edinger M, Negrin RS, Tait JF, Contag CH, Blankenberg FG. Multi-modality imaging identifies
key times for annexin v imaging as an early predictor of therapeutic outcome. Mol Imaging. 2004;3:1-8
Manicassamy B, Manicassamy S, Belicha-Villanueva A, Pisanelli G, Pulendran B, García-Sastre A. Analysis of in
vivo dynamics of influenza virus infection in mice using a gfp reporter virus. Proceedings of the National
Academy of Sciences of the United States of America. 2010;107:11531-11536
Mann B, Orihuela C, Antikainen J, Gao G, Sublett J, Korhonen TK, Tuomanen E. Multifunctional role of choline
binding protein g in pneumococcal pathogenesis. Infection and Immunity. 2006;74:821-829
Manning HC, Merchant NB, Foutch AC, Virostko JM, Wyatt SK, Shah C, McKinley ET, Xie J, Mutic NJ,
Washington MK, LaFleur B, Tantawy MN, Peterson TE, Ansari MS, Baldwin RM, Rothenberg ML, Bornhop DJ,
Gore JC, Coffey RJ. Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in
colorectal cancer. Clinical Cancer Research. 2008;14:7413-7422
Maoz A, Mayr R, Bresolin G, Neuhaus K, Francis KP, Scherer S. Sensitive in situ monitoring of a recombinant
bioluminescent yersinia enterocolitica reporter mutant in real time on camembert cheese. Applied and
Environmental Microbiology. 2002;68:5737-5740
Marchini C, Gabrielli F, Iezzi M, Zenobi S, Montani M, Pietrella L, Kalogris C, Rossini A, Ciravolo V, Castagnoli
L, Tagliabue E, Pupa SM, Musiani P, Monaci P, Menard S, Amici A. The human splice variant delta16her2 induces
rapid tumor onset in a reporter transgenic mouse. PloS one. 2011;6:e18727
Marcus A, Waks T, Eshhar Z. Redirected tumor-specific allogeneic t cells for universal treatment of cancer. Blood.
2011;118:975-983
Marian CO, Cho SK, McEllin BM, Maher EA, Hatanpaa KJ, Madden CJ, Mickey BE, Wright WE, Shay JW, Bachoo
RM. The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to
decreased proliferation and tumor growth. Clin Cancer Res. 2010;16:154-163
Marini F, Dembinski J, Studeny M, Zompetta C, Andreeff M. Mesenchymal stem cells as delivery systems for
cancer therapy: Evaluation of tropism and efficacy. Molecular Therapy. 2005;11:S173
Marini FC, Dembinski JL, Studery M, Ling X, Zompetta C, Andreeff M. Mesenchymal stem cells selectively
engraft into tumor stroma and confer potent antitumor activity. Cytotherapy. 2006;8:282
Markey KA, Burman AC, Banovic T, Kuns RD, Raffelt NC, Rowe V, Olver SD, Don AL, Morris ES, Pettit AR,
Wilson YA, Robb RJ, Randall LM, Korner H, Engwerda CR, Clouston AD, Macdonald KP, Hill GR. Soluble
lymphotoxin is an important effector molecule in gvhd and gvl. Blood. 2010;115:122-132
Marpegan L, Krall TJ, Herzog ED. Vasoactive intestinal polypeptide entrains circadian rhythms in astrocytes.
Journal of Biological Rhythms. 2009;24:135-143
Marquardt A, Halle S, Seckert CK, Lemmermann NA, Veres TZ, Braun A, Maus UA, Forster R, Reddehase MJ,
Messerle M, Busche A. Single cell detection of latent cytomegalovirus reactivation in host tissue. The Journal of
general virology. 2011
Marques CP, Cheeran MC, Palmquist JM, Hu S, Urban SL, Lokensgard JR. Prolonged microglial cell activation
and lymphocyte infiltration following experimental herpes encephalitis. J Immunol. 2008;181:6417-6426
Marques CP, Cheeran MCJ, Palmquist JM, Hu S, Lokensgard JR. Microglia are the major cellular source of inos
during experimental herpes encephalitis. Journal of Neurovirology. 2008;14:229-238
Marr AK, Overhage J, Bains M, Hancock RE. The lon protease of pseudomonas aeruginosa is induced by
aminoglycosides and is involved in biofilm formation and motility. Microbiology. 2007;153:474-482
Martens A, Kutschka I, Rojas-Hernandez S, Brilloff S, Rathert C, Martin U, Haverich A, Zweigerdt R. Improvement
of stem cell biodistribution in myocardial restoration. A quantitative analysis using fluorescent microspheres.
Human Gene Therapy. 2009;20:1456
1649.
1650.
1651.
1652.
1653.
1654.
1655.
1656.
1657.
1658.
1659.
1660.
1661.
1662.
1663.
1664.
1665.
1666.
1667.
1668.
1669.
1670.
1671.
1672.
1673.
Martens A, Rojas SV, Zweigerdt R, Rathert C, Martin U, Haverich A, Kutschka I. Improvement of biodistribution
in cardiac stem cell therapy using fibrinogen. Journal of the American College of Cardiology.
2010;55:A117.E1091
Marti GP, Mohebi P, Liu L, Wang J, Miyashita T, Harmon JW. Kgf-1 for wound healing in animal models.
Electroporation protocols. 2007:383-391.
Marti GP, Mohebi P, Liu L, Wang J, Miyashita T, Harmon JW. Kgf-1 for wound healing in animal models. Methods
Mol Biol. 2008;423:383-391
Martin D, Galisteo R, Molinolo AA, Wetzker R, Hirsch E, Gutkind JS. Pi3kgamma mediates kaposi's sarcomaassociated herpesvirus vgpcr-induced sarcomagenesis. Cancer cell. 2011;19:805-813
Martinez EC, Wang J, Gan SU, Singh R, Lee CN, Kofidis T. Ascorbic acid improves embryonic cardiomyoblast cell
survival and promotes vascularization in potential myocardial grafts in vivo. Tissue Eng Part A. 2010
Martinez-Fernandez A, Nelson TJ, Yamada S, Reyes S, Alekseev AE, Perez-Terzic C, Ikeda Y, Terzic A. Ips
programmed without c-myc yield proficient cardiogenesis for functional heart chimerism. Circulation Research.
2009;105:648-656
Martiniello-Wilks R, Larsen SR, Tiffen JC, Bailey CG, Rasko JEJ. Mesenchymal stem cells as suicide gene
therapy vehicles for organ-confined and metastatic prostate cancer (pca). Blood. 2007;110:369B
Marttila-Ichihara F, Auvinen K, Elima K, Jalkanen S, Salmi M. Vascular adhesion protein-1 enhances tumor
growth by supporting recruitment of gr-1+cd11b+ myeloid cells into tumors. Cancer Res. 2009;69:7875-7883
Marttila-Ichihara F, Turja R, Miiluniemi M, Karikoski M, Maksimow M, Niemela J, Martinez-Pomares L, Salmi M,
Jalkanen S. Macrophage mannose receptor on lymphatics controls cell trafficking. Blood. 2008;112:64-72
Masiero M, Minuzzo S, Pusceddu I, Moserle L, Persano L, Agnusdei V, Tosello V, Basso G, Amadori A, Indraccolo
S. Notch3-mediated regulation of mkp-1 levels promotes survival of t acute lymphoblastic leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2011;25:588-598
Masini B, Stinner D, Waterman S, Wenke J. Bacterial adherence to suture materials. Journal of Surgical
Education. 2010;194:35-41
Mason KM, Munson RS, Bakaletz LO. A mutation in the sap operon attenuates survival of nontypeable
haemophilus influenzae in a chinchilla model of otitis media. Infection and Immunity. 2005;73:599-608
Masotti A, Vicennati P, Boschi F, Calderan L, Sbarbati A, Ortaggi G. A novel near-infrared indocyanine dyepolyethylenimine conjugate allows DNA delivery imaging in vivo. Bioconjugate Chemistry. 2008;19:983-987
Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, Warren A, Scott H, Madhu B, Sharma N, Bon H,
Zecchini V, Smith DM, Denicola GM, Mathews N, Osborne M, Hadfield J, Macarthur S, Adryan B, Lyons SK,
Brindle KM, Griffiths J, Gleave ME, Rennie PS, Neal DE, Mills IG. The androgen receptor fuels prostate cancer by
regulating central metabolism and biosynthesis. The EMBO journal. 2011;30:2719-2733
Massoud TF, Paulmurugan R, Gambhir SS. Molecular imaging of homodimeric protein-protein interactions in
living subjects. Faseb J. 2004;18:1105-1107
Masuda H, Maruyama T, Hiratsu E, Yamane J, Iwanami A, Nagashima T, Ono M, Miyoshi H, Okano HJ, Ito M,
Tamaoki N, Nomura T, Okano H, Matsuzaki Y, Yoshimura Y. Noninvasive and real-time assessment of
reconstructed functional human endometrium in nod/scid/γcnull immunodeficient mice. Proceedings of the
National Academy of Sciences of the United States of America. 2007;104:1925-1930
Matis S, Mariani MR, Cutrona G, Cilli M, Piccardi F, Daga A, Damonte G, Millo E, Moroni M, Roncella S, Fedeli F,
Boffa LC, Ferrarini M. Pnaemu can significantly reduce burkitt's lymphoma tumor burden in a scid mice model:
Cells dissemination similar to the human disease. Cancer Gene Ther. 2009
Matrone MA, Whipple RA, Thompson K, Cho EH, Vitolo MI, Balzer EM, Yoon JR, Ioffe OB, Tuttle KC, Tan M,
Martin SS. Metastatic breast tumors express increased tau, which promotes microtentacle formation and the
reattachment of detached breast tumor cells. Oncogene. 2010;29:3217-3227
Matsui M, Shimizu Y, Kodera Y, Kondo E, Ikehara Y, Nakanishi H. Targeted delivery of oligomannose-coated
liposome to the omental micrometastasis by peritoneal macrophages from patients with gastric cancer. Cancer
Sci. 2010;101:1670-1677
Matsui Y, Watanabe J, Ikegawa M, Kamoto T, Ogawa O, Nishiyama H. Cancer-specific enhancement of cisplatininduced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3beta with
p53. Oncogene. 2008;27:4603-4614
Matsumoto H, Kimura T, Haga K, Kasahara N, Anton P, McGowan I. Effective in vivo and ex vivo gene transfer to
intestinal mucosa by vsv-g-pseudotyped lentiviral vectors. BMC Gastroenterol. 2010;10:44
Matsumoto S, Tanaka F, Katakura H, Adachi M, Kimura S, Maekawa T, Wada H. Monitoring of disseminated
pleural tumors using non-invasive bioluminescent in vivo imaging system. Proceedings of the American
Association for Cancer Research. 2005;2005:245
Matsumoto S, Tanaka F, Sato K, Kimura S, Maekawa T, Hasegawa S, Wada H. Monitoring with a non-invasive
bioluminescent in vivo imaging system of pleural metastasis of lung carcinoma. Lung Cancer. 2009;66:75-79
Matthews QL, Sibley DA, Wu H, Li J, Stoff-Khalili MA, Waehler R, Mathis JM, Curiel DT. Genetic incorporation of
a herpes simplex virus type 1 thymidine kinase and firefly luciferase fusion into the adenovirus protein ix for
functional display on the virion. Mol Imaging. 2006;5:510-519
Mauti LA, Le Bitoux MA, Baumer K, Stehle JC, Golshayan D, Provero P, Stamenkovic I. Myeloid-derived
suppressor cells are implicated in regulating permissiveness for tumor metastasis during mouse gestation. The
Journal of clinical investigation. 2011;121:2794-2807
1674.
1675.
1676.
1677.
1678.
1679.
1680.
1681.
1682.
1683.
1684.
1685.
1686.
1687.
1688.
1689.
1690.
1691.
1692.
1693.
1694.
1695.
1696.
1697.
1698.
1699.
1700.
Mayer-Kuckuk P, Gade TP, Buchanan IM, Doubrovin M, Ageyeva L, Bertino JR, Boskey AL, Blasberg RG,
Koutcher JA, Banerjee D. High-resolution imaging of bone precursor cells within the intact bone marrow cavity
of living mice. Mol Ther. 2005;12:33-41
Mays LE, Vandenberghe LH, Xiao R, Bell P, Nam HJ, Agbandje-McKenna M, Wilson JM. Adeno-associated virus
capsid structure drives cd4-dependent cd8+ t cell response to vector encoded proteins. J Immunol.
2009;182:6051-6060
Maysinger D, Behrendt M, Lalancette-Hebert M, Kriz J. Real-time imaging of astrocyte response to quantum dots:
In vivo screening model system for biocompatibility of nanoparticles. Nano Lett. 2007;7:2513-2520
McAnuff MA, Rettig GR, Rice KG. Potency of sirna versus shrna mediated knockdown in vivo. J Pharm Sci.
2007;96:2922-2930
McAuley JL, Hornung F, Boyd KL, Smith AM, McKeon R, Bennink J, Yewdell JW, McCullers JA. Expression of
the 1918 influenza a virus pb1-f2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell
Host Microbe. 2007;2:240-249
McBride G. The many ways that optical techniques are increasingly being used in cancer diagnosis &
monitoring. Oncology Times. 2004;26:11
McCaffrey A, Kay MA, Contag CH. Advancing molecular therapies through in vivo bioluminescent imaging. Mol
Imaging. 2003;2:75-86
McCaffrey AP, Meuse L, Karimi M, Contag CH, Kay MA. A potent and specific morpholino antisense inhibitor of
hepatitis c translation in mice. Hepatology. 2003;38:503-508
McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, Kay MA. Rna interference in adult mice. Nature.
2002;418:38-39
McCaffrey AP, Ohashi K, Meuse L, Shen S, Lancaster AM, Lukavsky PJ, Sarnow P, Kay MA. Determinants of
hepatitis c translational initiation in vitro, in cultured cells and mice. Mol Ther. 2002;5:676-684
McCullers J. Effect of antiviral treatment on the outcome of secondary bacterial pneumonia after influenza. The
Journal of infectious diseases. 2004;190:519-526
McCullers JA, Bartmess KC. Role of neuraminidase in lethal synergism between influenza virus and
streptococcus pneumoniae. J Infect Dis. 2003;187:1000-1009
McCullers JA, Karlstrom A, Iverson AR, Loeffler JM, Fischetti VA. Novel strategy to prevent otitis media caused
by colonizing streptococcus pneumoniae. PLoS Pathog. 2007;3:e28
McDevitt M, Chattopadhyay D, Kappel B, Jaggi J, Schiffman S, Antczak C, Njardarson J, Brentjens R, Scheinberg
D. Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. Journal of Nuclear Medicine.
2007;48:1180
McGee MC, Hamner JB, Williams RF, Rosati SF, Sims TL, Ng CY, Gaber MW, Calabrese C, Wu J, Nathwani AC,
Duntsch C, Merchant TE, Davidoff AM. Improved intratumoral oxygenation through vascular normalization
increases glioma sensitivity to ionizing radiation. Int J Radiat Oncol Biol Phys. 2010;76:1537-1545
McGillivary G, Bakaletz LO. The multifunctional host defense peptide splunc1 is critical for homeostasis of the
mammalian upper airway. PLoS One. 2010;5
McIntyre JO, Matrisian LM. Optical proteolytic beacons for in vivo detection of matrix metalloproteinase
activity. Proteases and cancer. 2008:1-20.
McIntyre JO, Matrisian LM. Optical proteolytic beacons for in vivo detection of matrix metalloproteinase
activity. Methods Mol Biol. 2009;539:155-174
McIntyre JO, Scherer RL, Matrisian LM. Near-infrared optical proteolytic beacons for in vivo imaging of matrix
metalloproteinase activity. Matrix metalloproteinase protocols. 2009:279-304.
McLaughlin J, Cheng D, Singer O, Lukacs RU, Radu CG, Verma IM, Witte ON. Sustained suppression of bcr-abldriven lymphoid leukemia by microrna mimics. Proceedings of the National Academy of Sciences of the United
States of America. 2007;104:20501-20506
McLean K, Gong Y, Choi Y, Deng N, Yang K, Bai S, Cabrera L, Keller E, McCauley L, Cho KR, Buckanovich RJ.
Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via
altered bmp production. The Journal of clinical investigation. 2011
McMillin DW, Delmore J, Negri J, Ooi M, Klippel S, Miduturu CV, Gray NS, Richardson PG, Anderson KC, Kung
AL, Mitsiades CS. Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in
multiple myeloma: Implications for clinical translation. PloS one. 2011;6:e20226
McMillin DW, Delmore J, Weisberg E, Negri JM, Geer DC, Klippel S, Mitsiades N, Schlossman RL, Munshi NC,
Kung AL, Griffin JD, Richardson PG, Anderson KC, Mitsiades CS. Tumor cell-specific bioluminescence platform
to identify stroma-induced changes to anticancer drug activity. Nature medicine. 2010;16:483-489
MEDICHERLA S, LI L, MA J, KAPOUN A, GASPAR N, LIU Y, MANGADU R, O'YOUNG G, PROTTER A,
SCHREINER G. Antitumor activity of tgf-beta inhibitor is dependent on the microenvironment. Anticancer
Research. 2007;27:4149
Meguro A, Ozaki K, Hatanaka K, Oh I, Sudo K, Ohmori T, Matsu H, Tatara R, Sato K, Sakata Y, Nakae S, Leonard
WJ, Ozawa K. Lack of il-21 signal attenuates graft-versus-leukemia effect in the absence of cd8 t-cells. Bone
marrow transplantation. 2011
Meijer J, Ogink J, Kreike B, Nuyten D, de Visser KE, Roos E. The chemokine receptor cxcr6 and its ligand cxcl16
are expressed in carcinomas and inhibit proliferation. Cancer Res. 2008;68:4701-4708
Meijer J, Ogink J, Roos E. Effect of the chemokine receptor cxcr7 on proliferation of carcinoma cells in vitro and
1701.
1702.
1703.
1704.
1705.
1706.
1707.
1708.
1709.
1710.
1711.
1712.
1713.
1714.
1715.
1716.
1717.
1718.
1719.
1720.
1721.
1722.
1723.
1724.
in vivo. British Journal of Cancer. 2008;99:1493-1501
Meijer J, Zeelenberg I, Sipos B, Roos E. The cxcr5 chemokine receptor is expressed by carcinoma cells and
promotes growth of colon carcinoma in the liver. Cancer Res. 2006;66:9576
Melancon MP, Elliott AM, Shetty A, Huang Q, Stafford RJ, Li C. Near-infrared light modulated photothermal
effect increases vascular perfusion and enhances polymeric drug delivery. Journal of controlled release :
official journal of the Controlled Release Society. 2011
Melancon MP, Wang W, Wang Y, Shao R, Ji X, Gelovani JG, Li C. A novel method for imaging in vivo
d eg rad at i o n o f p o l y (l -g l u t ami c aci d ), a b i o d eg rad ab l e d ru g carri er. Ph a r ma ceu t i ca l Res ea r ch .
2007;24:1217-1224
Melancon MP, Wang Y, Wen X, Bankson JA, Stephens LC, Jasser S, Gelovani JG, Myers JN, Li C. Development of
a macromolecular dual-modality mr-optical imaging for sentinel lymph node mapping. Investigative Radiology.
2007;42:569-578
Melillo G. Hypoxia-inducible factor 1 inhibitors. Methods in Enzymology. 2007;435:385-402
Melisi D, Ishiyama S, Sclabas GM, Fleming JB, Xia Q, Tortora G, Abbruzzese JL, Chiao PJ. Ly2109761, a novel
transforming growth factor beta receptor type i and type ii dual inhibitor, as a therapeutic approach to
suppressing pancreatic cancer metastasis. Mol Cancer Ther. 2008;7:829-840
Melisi D, Niu J, Chang Z, Xia Q, Peng B, Ishiyama S, Evans DB, Chiao PJ. Secreted interleukin-1α induces a
metastatic phenotype in pancreatic cancer by sustaining a constitutive activation of nuclear factor-κb. Mol
Cancer Res. 2009;7:624-633
Melisi D, Ossovskaya V, Zhu C, Rosa R, Ling J, Dougherty PM, Sherman BM, Abbruzzese JL, Chiao PJ. Oral poly
(adp-ribose) polymerase-1 inhibitor bsi-401 has antitumor activity and synergizes with oxaliplatin against
pancreatic cancer, preventing acute neurotoxicity. Clinical Cancer Research. 2009;15:6367-6377
Melisi D, Xia Q, Paradiso G, Ling J, Moccia T, Carbone C, Budillon A, Abbruzzese JL, Chiao PJ. Modulation of
pancreatic cancer chemoresistance by inhibition of tak1. Journal of the National Cancer Institute.
2011;103:1190-1204
Melton L. Imaging: The big picture. Nature. 2005;437:775-779
Menanteau-Ledouble S, Karsi A, Lawrence ML. Importance of skin abrasion as a primary site of adhesion for
edwardsiella ictaluri and impact on invasion and systematic infection in channel catfish ictalurus punctatus.
Veterinary microbiology. 2011;148:425-430
Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ,
Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S,
McMahon G, Cherrington JM. In vivo antitumor activity of su11248, a novel tyrosine kinase inhibitor targeting
vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a
pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res. 2003;9:327-337
Merchant NB, Voskresensky I, Rogers CM, Lafleur B, Dempsey PJ, Graves-Deal R, Revetta F, Foutch AC,
Rothenberg ML, Washington MK, Coffey RJ. Tace/adam-17: A component of the epidermal growth factor receptor
axis and a promising therapeutic target in colorectal cancer. Clin Cancer Res. 2008;14:1182-1191
Mi J, Sarraf-Yazdi S, Zhang X, Cao Y, Dewhirst MW, Kontos CD, Li C-Y, Clary BM. A comparison of
antiangiogenic therapies for the prevention of liver metastases. Journal of Surgical Research. 2006;In Press,
Corrected Proof
Mi Z, Bhattacharya SD, Kim VM, Guo H, Talbot LJ, Kuo PC. Osteopontin promotes ccl5-mesenchymal stromal
cell-mediated breast cancer metastasis. Carcinogenesis. 2011;32:477-487
Mi Z, Guo H, Russell MB, Liu Y, Sullenger BA, Kuo PC. Rna aptamer blockade of osteopontin inhibits growth
and metastasis of mda-mb231 breast cancer cells. Mol Ther. 2009;17:153-161
Mian OY, Wang SZ, Zhu SZ, Gnanapragasam MN, Graham L, Bear HD, Ginder GD. Methyl-binding domain protein
2-dependent proliferation and survival of breast cancer cells. Molecular cancer research : MCR. 2011
Michaud F, Coulombe F, Gaudreault É, Kriz J, Gosselin J. Involvement of tlr2 in recognition of acute
gammaherpesvirus-68 infection. PLoS One. 2010;5
Michaud K, Solomon DA, Oermann E, Kim JS, Zhong WZ, Prados MD, Ozawa T, James CD, Waldman T.
Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme
intracranial xenografts. Cancer Res. 2010;70:3228-3238
Michelini E, Cevenini L, Mezzanotte L, Roda A. Luminescent probes and visualization of bioluminescence.
Bioluminescence. 2009:1-13.
Mieog JS, Hutteman M, van der Vorst JR, Kuppen PJ, Que I, Dijkstra J, Kaijzel EL, Prins F, Lowik CW, Smit VT,
van de Velde CJ, Vahrmeijer AL. Image-guided tumor resection using real-time near-infrared fluorescence in a
syngeneic rat model of primary breast cancer. Breast Cancer Res Treat. 2011;128:679-689
Migalovich HS, Kalchenko V, Nevo N, Meir G, Kohen F, Neeman M. Harnessing competing endocytic pathways
for overcoming the tumor-blood barrier: Mri and nir imaging of bifunctional contrast media. Cancer Res.
2009;69:5610-5617
Migita T, Ruiz S, Fornari A, Fiorentino M, Priolo C, Zadra G, Inazuka F, Grisanzio C, Palescandolo E, Shin E, Fiore
C, Xie W, Kung AL, Febbo PG, Subramanian A, Mucci L, Ma J, Signoretti S, Stampfer M, Hahn WC, Finn S, Loda
M. Fatty acid synthase: A metabolic enzyme and candidate oncogene in prostate cancer. Journal of the National
Cancer Institute. 2009;101:519-532
Miki K, Kuramochi Y, Oride K, Inoue S, Harada H, Hiraoka M, Ohe K. Ring-opening metathesis polymerization-
1725.
1726.
1727.
1728.
1729.
1730.
1731.
1732.
1733.
1734.
1735.
1736.
1737.
1738.
1739.
1740.
1741.
1742.
1743.
1744.
1745.
1746.
1747.
1748.
based synthesis of icg-containing amphiphilic triblock copolymers for in vivo tumor imaging. Bioconjug Chem.
2009
Miki K, Oride K, Inoue S, Kuramochi Y, Nayak RR, Matsuoka H, Harada H, Hiraoka M, Ohe K. Ring-opening
metathesis polymerization-based synthesis of polymeric nanoparticles for enhanced tumor imaging in vivo:
Synergistic effect of folate-receptor targeting and pegylation. Biomaterials. 2010;31:934-942
Milho R, Smith CM, Marques S, Alenquer M, May JS, Gillet L, Gaspar M, Efstathiou S, Simas JP, Stevenson PG. In
vivo imaging of murid herpesvirus-4 infection. J Gen Virol. 2009;90:21-32
Miller L, O'Connell R, Gutierrez M, Pietras E, Shahangian A, Gross C, Thirumala A, Cheung A, Cheng G, Modlin R.
Myd88 mediates neutrophil recruitment initiated by il-1r but not tlr2 activation in immunity against
staphylococcus aureus. Immunity. 2006;24:79-91
Miller L, Pietras E, Uricchio L, Hirano K, Rao S, Lin H, O'Connell R, Iwakura Y, Cheung A, Cheng G.
Inflammasome-mediated production of il-1beta is required for neutrophil recruitment against staphylococcus
aureus in vivo. The Journal of Immunology. 2007;179:6933
Miller ML, Gao G, Pestina T, Persons D, Tuomanen E. Hypersusceptibility to invasive pneumococcal infection in
experimental sickle cell disease involves platelet-activating factor receptor. J Infect Dis. 2007;195:581-584
Miller RE, Roudier M, Jones J, Armstrong A, Canon J, Dougall WC. Rank ligand inhibition plus docetaxel
improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis. Mol Cancer
Ther. 2008;7:2160-2169
Millington OR, Myburgh E, Mottram JC, Alexander J. Imaging of the host/parasite interplay in cutaneous
leishmaniasis. Experimental parasitology. 2010;126:310-317
Miloud T, Henrich C, Hämmerling G. Quantitative comparison of click beetle and firefly luciferases for in vivo
bioluminescence imaging. Journal of biomedical optics. 2007;12:054018
Min J, Biswal S, Deroose C, Gambhir S. Tetraphenylphosphonium as a novel molecular probe for imaging tumors.
Journal of Nuclear Medicine. 2004;45:636
Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, Macconaill LE,
Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K. An oncogene-tumor suppressor cascade
drives metastatic prostate cancer by coordinately activating ras and nuclear factor-kappab. Nat Med. 2010
Min JJ, Ahn Y, Moon S, Kim YS, Park JE, Kim SM, Le UN, Wu JC, Joo SY, Hong MH, Yang DH, Jeong MH, Song
CH, Jeong YH, Yoo KY, Kang KS, Bom HS. In vivo bioluminescence imaging of cord blood derived mesenchymal
stem cell transplantation into rat myocardium. Annals of Nuclear Medicine. 2006;20:165-170
Min JJ, Kim HJ, Park JH, Moon S, Jeong JH, Hong YJ, Cho KO, Nam JH, Kim N, Park YK, Bom HS, Rhee JH, Choy
HE. Noninvasive real-time imaging of tumors and metastases using tumor-targeting light-emitting escherichia
coli. Mol Imaging Biol. 2008;10:54-61
Min JJ, Nguyen VH, Kim HJ, Hong Y, Choy HE. Quantitative bioluminescence imaging of tumor-targeting
bacteria in living animals. Nat Protoc. 2008;3:629-636
Minakuchi Y, Takeshita F, Kosaka N, Sasaki H, Yamamoto Y, Kouno M, Honma K, Nagahara S, Hanai K, Sano A,
Kato T, Terada M, Ochiya T. Atelocollagen-mediated synthetic small interfering rna delivery for effective gene
silencing in vitro and in vivo. Nucleic Acids Res. 2004;32:e109
Minami K, Hasegawa M, Ito H, Nakamura A, Tomii T, Matsumoto M, Orita S, Matsushima S, Miyoshi T, Masuno K,
Torii M, Koike K, Shimada S, Kanemasa T, Kihara T, Narita M, Suzuki T, Kato A. Morphine, oxycodone, and
fentanyl exhibit different analgesic profiles in mouse pain models. J Pharmacol Sci. 2009;111:60-72
Minko T, Patil ML, Zhang M, Khandare JJ, Saad M, Chandna P, Taratula O. Lhrh-targeted nanoparticles for cancer
therapeutics. Methods Mol Biol. 2010;624:281-294
Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, Viale A, Olshen AB, Gerald WL, Massagué J. Genes that
mediate breast cancer metastasis to lung. Nature. 2005;436:518-524
Minn AJ, Kang Y, Serganova I, Gupta GP, Giri DD, Doubrovin M, Ponomarev V, Gerald WL, Blasberg R, Massagué
J. Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. Journal of
Clinical Investigation. 2005;115:44-55
Miretti S, Roato I, Taulli R, Ponzetto C, Cilli M, Olivero M, Di Renzo MF, Godio L, Albini A, Buracco P, Ferracini
R. A mouse model of pulmonary metastasis from spontaneous osteosarcoma monitored in vivo by luciferase
imaging. PLoS One. 2008;3
Mirmonsef P, Tan G, Zhou G, Morino T, Noonan K, Borrello I, Levitsky HI. Escape from suppression: Tumorspecific effector cells outcompete regulatory t cells following stem-cell transplantation. Blood.
2008;111:2112-2121
Mishra PJ, Menon LG, Mayer-Kuckuk P, Bertino JR, Banerjee D. Translational modulation of proteins expressed
from bicistronic vectors. Mol Imaging. 2009;8:305-318
Mishra S, Tang Y, Wang L, Degraffenried L, Yeh IT, Werner S, Troyer D, Copland JA, Sun LZ. Blockade of
transforming growth factor-beta (tgfbeta) signaling inhibits osteoblastic tumorigenesis by a novel human
prostate cancer cell line. Prostate. 2011
Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS,
Underwood KW, Seehra J, Kumar R. Alk1-fc inhibits multiple mediators of angiogenesis and suppresses tumor
growth. Mol Cancer Ther. 2010;9:379-388
Mitomo K, Griesenbach U, Inoue M, Somerton L, Meng C, Akiba E, Tabata T, Ueda Y, Frankel GM, Farley R, Singh
C, Chan M, Munkonge F, Brum A, Xenariou S, Escudero-Garcia S, Hasegawa M, Alton EW. Toward gene therapy
1749.
1750.
1751.
1752.
1753.
1754.
1755.
1756.
1757.
1758.
1759.
1760.
1761.
1762.
1763.
1764.
1765.
1766.
1767.
1768.
1769.
1770.
1771.
1772.
1773.
for cystic fibrosis using a lentivirus pseudotyped with sendai virus envelopes. Molecular therapy : the journal
of the American Society of Gene Therapy. 2010;18:1173-1182
Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M, Hideshima T, Chauhan D,
Joseph M, Libermann TA, Garcia-Echeverria C, Pearson MA, Hofmann F, Anderson KC, Kung AL. Inhibition of the
insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma,
other hematologic malignancies, and solid tumors. Cancer Cell. 2004;5:221-230
Mittermayr R, Hartinger J, Antonic V, Meinl A, Pfeifer S, Stojadinovic A, Schaden W, Redl H. Extracorporeal
shock wave therapy (eswt) minimizes ischemic tissue necrosis irrespective of application time and promotes
tissue revascularization by stimulating angiogenesis. Annals of surgery. 2011;253:1024-1032
Mittermayr R, Morton T, Hofmann M, Helgerson S, van Griensven M, Redl H. Sustained (rh)vegf(165) release
from a sprayed fibrin biomatrix induces angiogenesis, up-regulation of endogenous vegf-r2, and reduces
ischemic flap necrosis. Wound Repair Regen. 2008;16:542-550
Miyagi T, Anderson C, Odero-Marah V, Johnstone P, Chung L. Growth and colonization of human prostate cancer
cells in bone: Roles of stroma and effects of radiation. Proceedings of the American Association for Cancer
Research. 2005;2005:231
Miyahira AK, Shahangian A, Hwang S, Sun R, Cheng G. Tank-binding kinase-1 plays an important role during in
vitro and in vivo type i interferon responses to DNA virus infections1. Journal of Immunology.
2009;182:2248-2257
Miyawaki A. Bringing bioluminescence into the picture. Nat Methods. 2007;4:616-617
Mizuno T, Mohri K, Nasu S, Danjo K, Okamoto H. Dual imaging of pulmonary delivery and gene expression of
dry powder inhalant by fluorescence and bioluminescence. J Control Release. 2009;134:149-154
Mizutani K, Sud S, McGregor NA, Martinovski G, Rice BT, Craig MJ, Varsos ZS, Roca H, Pienta KJ. The
chemokine ccl2 increases prostate tumor growth and bone metastasis through macrophage and osteoclast
recruitment1. Neoplasia. 2009;11:1235-1242
Mocanu J, Yip K, Alajez N, Shi W, Li JH, Lunt S, Moriyama E, Wilson B, Milosevic M, Lo K, van Rooijen N,
Busson P, Bastianutto C, Liu FF. Imaging the modulation of adenoviral kinetics and biodistribution for cancer
gene therapy. Mol Ther. 2007
Mocanu JD, Chia MC, Shi W, Li J-H, Yip KW, Moriyama EH, Huang D, Wilson BC, Liu F-F. The use of
bioluminescent imaging (bli) to evaluate biodistribution and kinetics of nasopharyngeal carcinoma-specific
adenoviral gene therapy vectors. Proceedings of the American Association for Cancer Research Annual Meeting.
2004;45:47
Mocanu JD, Moriyama EH, Chia MC, Li JH, Yip KW, Huang DP, Bastianutto C, Wilson BC, Liu FF. Combined in
vivo bioluminescence and fluorescence imaging for cancer gene therapy. Mol Imaging. 2004;3:352-355
Mochizuki K, Liu Y, Wang S, Kim C, Gerwitz J, Alavi A, El-Deiry W. Three-dimensional bioluminescent imaging
of tumor xenografts. Proceedings of the American Association for Cancer Research. 2005;2005:903
Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL,
Bradner JE. Direct inhibition of the notch transcription factor complex. Nature. 2009;462:182-188
Mohammad KS, Chen CG, Balooch G, Stebbins E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DHN,
Ionova-Martin SS, Bracey JW, Hogue WR, Wong DH, Ritchie RO, Suva LJ, Derynck R, Guise TA, Alliston T.
Pharmacologic inhibition of the tgf-β type i receptor kinase has anabolic and anti-catabolic effects on bone.
PLoS One. 2009;4
Mohri K, Okuda T, Mori A, Danjo K, Okamoto H. Optimized pulmonary gene transfection in mice by spray-freeze
dried powder inhalation. J Control Release. 2010;144:221-226
Momota H, Holland EC. Bioluminescence technology for imaging cell proliferation. Current Opinion in
Biotechnology. 2005;16:681-686
Monfared P, Winkeler A, Klein M, Li H, Klose A, Hoesel M, Waerzeggers Y, Korsching S, Jacobs AH. Noninvasive
assessment of e2f-1-mediated transcriptional regulation in vivo. Cancer Res. 2008;68:5932-5940
Mongiat M, Marastoni S, Ligresti G, Lorenzon E, Schiappacassi M, Perris R, Frustaci S, Colombatti A. The
extracellular matrix glycoprotein elastin microfibril interface located protein 2: A dual role in the tumor
microenvironment. Neoplasia. 2010;12:294-304
Monk IR, Gahan CG, Hill C. Tools for functional postgenomic analysis of listeria monocytogenes. Appl Environ
Microbiol. 2008;74:3921-3934
Mook-Kanamori BB, Rouse MS, Kang CI, van de Beek D, Steckelberg JM, Patel R. Daptomycin in experimental
murine pneumococcal meningitis. BMC Infect Dis. 2009;9:50
Moon SH, Kim JS, Park SJ, Lee HJ, Do JT, Chung HM. A system for treating ischemic disease using human
embryonic stem cell-derived endothelial cells without direct incorporation. Biomaterials. 2011;32:6445-6455
MOREAU J, ANDERSON K, MAUNEY J, KAPLAN D, ROSENBLATT M. Studies of osteotropism on both sides of
the breast cancer–bone interaction. Annals of the New York Academy of Sciences. 2007;1117:328-344
Moreau J, Anderson K, Mauney J, Nguyen T, Kaplan D, Rosenblatt M. Tissue-engineered bone serves as a target
for metastasis of human breast cancer in a mouse model. Cancer Res. 2007;67:10304
Mori A, Sakurai H, Choo M, Obi R, Koizumi K, Yoshida C, Shimada Y, Saiki I. Severe pulmonary metastasis in
obese and diabetic mice. International Journal of Cancer. 2006;119:2760-2767
Morikawa S, Mabuchi Y, Kubota Y, Nagai Y, Niibe K, Hiratsu E, Suzuki S, Miyauchi-Hara C, Nagoshi N, Sunabori
T, Shimmura S, Miyawaki A, Nakagawa T, Suda T, Okano H, Matsuzaki Y. Prospective identification, isolation,
1774.
1775.
1776.
1777.
1778.
1779.
1780.
1781.
1782.
1783.
1784.
1785.
1786.
1787.
1788.
1789.
1790.
1791.
1792.
1793.
1794.
1795.
1796.
1797.
1798.
1799.
and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. Journal of
Experimental Medicine. 2009;206:2483-2496
Morin CE, Kaper JB. Use of stabilized luciferase-expressing plasmids to examine in vivo-induced promoters in
the vibrio cholerae vaccine strain cvd 103-hgr. FEMS Immunol Med Microbiol. 2009;57:69-79
Morioka I, Wong RJ, Abate A, Vreman HJ, Contag CH, Stevenson DK. Systemic effects of orally-administered zinc
and tin (iv) metalloporphyrins on heme oxygenase expression in mice. Pediatr Res. 2006;59:667-672
Morisawa T, Wong RJ, Bhutani VK, Vreman HJ, Stevenson DK. Inhibition of heme oxygenase activity in newborn
mice by azalanstat. Can J Physiol Pharmacol. 2008;86:651-659
Moriyama EH, Bisland SK, Lilge L, Wilson BC. Bioluminescence imaging of the response of rat gliosarcoma to
ala-ppix-mediated photodynamic therapy. Photochem Photobiol. 2004;80:242-249
Moriyama EH, Niedre MJ, Jarvi MT, Mocanu JD, Moriyama Y, Subarsky P, Li B, Lilge LD, Wilson BC. The
influence of hypoxia on bioluminescence in luciferase-transfected gliosarcoma tumor cells in vitro. Photochem
Photobiol Sci. 2008;7:675-680
Moriyama Y, Moriyama E, Blackmore K, Akens M, Lilge L. In vivo study of the inflammatory modulating effects
of low level laser therapy on inos expression using bioluminescence imaging. Photochemistry and
Photobiology. 2005;81:1351-1355
Morizono K, Xie Y, Ringpis G, Johnson M, Nassanian H, Lee B, Wu L, Chen I. Lentiviral vector retargeting to pglycoprotein on metastatic melanoma through intravenous injection. Nature Medicine. 2005;11:346-352
Moroz E, Carlin S, Dyomina K, Burke S, Thaler HT, Blasberg R, Serganova I. Real-time imaging of hif-1α
stabilization and degradation. PLoS ONE. 2009
Moroz MA, Huang R, Kochetkov T, Shi W, Thaler H, de Stanchina E, Gamez I, Ryan RP, Blasberg RG. Comparison
of corticotropin-releasing factor, dexamethasone, and temozolomide: Treatment efficacy and toxicity in u87 and
c6 intracranial gliomas. Clinical cancer research : an official journal of the American Association for Cancer
Research. 2011;17:3282-3292
Morris ES, MacDonald KP, Rowe V, Banovic T, Kuns RD, Don AL, Bofinger HM, Burman AC, Olver SD, Kienzle N,
Porcelli SA, Pellicci DG, Godfrey DI, Smyth MJ, Hill GR. Nkt cell–dependent leukemia eradication following
stem cell mobilization with potent g-csf analogs. Journal of Clinical Investigation. 2005;115:3093-3103
Morrison J, Briggs S, Green N, Fisher K, Subr V, Ulbrich K, Kehoe S, Seymour L. Virotherapy of ovarian cancer
with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor. Molecular Therapy.
2007;16:244-251
Morrison J, Briggs SS, Green NK, Thoma C, Fisher KD, Kehoe S, Seymour LW. Cetuximab retargeting of
adenovirus via the epidermal growth factor receptor for treatment of intraperitoneal ovarian cancer. Hum Gene
Ther. 2009;20:239-251
Morrissey R, Begley M, Oshima S, Rea M, Ross RP, Hill C. Real-time monitoring of luciferase-tagged cronobacter
sakazakii in reconstituted infant milk formula. Journal of food protection. 2011;74:573-579
Mortin LI, Li T, Van Praagh AD, Zhang S, Zhang XX, Alder JD. Rapid bactericidal activity of daptomycin against
methicillin-resistant and methicillin-susceptible staphylococcus aureus peritonitis in mice as measured with
bioluminescent bacteria. Antimicrob Agents Chemother. 2007;51:1787-1794
Mortin LI, Yu D, Li T, Van Praagh A, Zhang X, Bao J, Alder J. Efficacy of daptomycin in a fibrin clot model of
endocarditis in rats using a bioluminescent methicillin-resistant staphylococcus aureus (mrsa). Abstracts of the
General Meeting of the American Society for Microbiology. 2003;103:A-025
Moskaug JO, Carlsen H, Blomhoff R. Noninvasive in vivo imaging of protein kinase a activity. Mol Imaging.
2008;7:35-41
Moskaug JO, Carlsen H, Myhrstad M, Blomhoff R. Molecular imaging of the biological effects of quercetin and
quercetin-rich foods. Mech Ageing Dev. 2004;125:315-324
Moskwa P, Lorentzen D, Excoffon K, Zabner J, McCray PB, Nauseef WM, Dupuy C, Bánfi B. A novel host defense
system of airways is defective in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine.
2007;175:174-183
Moss BL, Gross S, Gammon ST, Vinjamoori A, Piwnica-Worms D. Identification of a ligand-induced transient
refractory period in nuclear factor-kappab signaling. J Biol Chem. 2008;283:8687-8698
Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M,
Frohlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM.
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Gastroenterology. 2011;140:1272-1282
Mouchess M, Sohara Y, Nelson Jr M, DeClerck Y, Moats R. Multimodal imaging analysis of tumor progression
and bone resorption in a murine cancer model. Journal of Computer Assisted Tomography. 2006;30:525
Moulton K, Ryan P, Lay D, Willard S. Photonic plasmid stability of transformed salmonella typhimurium: A
comparison of three unique plasmids. BMC Microbiol. 2009;9:152
Moussavi M, Fazli L, Tearle H, Cox ME, Bell J, Ong C, Jia W, Rennie P. In vivo targeting and killing of mouse
prostate cancer tissue with vesicular stomatitis virus (vsv). Cancer Microenvironment. 2009;2:S191
Moussavi M, Fazli L, Tearle H, Guo Y, Cox M, Bell J, Ong C, Jia W, Rennie PS. Oncolysis of prostate cancers
induced by vesicular stomatitis virus in pten knockout mice. Cancer Res. 2010;70:1367-1376
Moyer P. Dmd: Gene transfer studies aim to overcome obstacles with viral vectors. Neurology Today. 2004;4:28
Msaouel P, Iankov ID, Allen C, Morris JC, von Messling V, Cattaneo R, Koutsilieris M, Russell SJ, Galanis E.
1800.
1801.
1802.
1803.
1804.
1805.
1806.
1807.
1808.
1809.
1810.
1811.
1812.
1813.
1814.
1815.
1816.
1817.
1818.
1819.
1820.
1821.
1822.
Engineered measles virus as a novel oncolytic therapy against prostate cancer. Prostate. 2009;69:82-91
Mu CJ, Lavan DA, Langer RS, Zetter BR. Self-assembled gold nanoparticle molecular probes for detecting
proteolytic activity in vivo. ACS Nano. 2010
Muders MH, Vohra PK, Dutta SK, Wang E, Ikeda Y, Wang L, Udugamasooriya DG, Memic A, Rupashinghe CN,
Baretton GB, Aust DE, Langer S, Datta K, Simons M, Spaller MR, Mukhopadhyay D. Targeting gipc/synectin in
pancreatic cancer inhibits tumor growth. Clinical Cancer Research. 2009;15:4095-4103
Mueller S, Yang X, Sottero TL, Gragg A, Prasad G, Polley MY, Weiss WA, Matthay KK, Davidoff AM, DuBois SG,
Haas-Kogan DA. Cooperation of the hdac inhibitor vorinostat and radiation in metastatic neuroblastoma:
Efficacy and underlying mechanisms. Cancer letters. 2011;306:223-229
Mugabe C, Matsui Y, So AI, Gleave ME, Baker JH, Minchinton AI, Manisali I, Liggins R, Brooks DE, Burt HM. In
vivo evaluation of mucoadhesive nanoparticulate docetaxel for intravesical treatment of non-muscle-invasive
bladder cancer. Clinical cancer research : an official journal of the American Association for Cancer Research.
2011;17:2788-2798
Mugabe C, Matsui Y, So AI, Gleave ME, Heller M, Zeisser-Labouebe M, Heller L, Chafeeva I, Brooks DE, Burt HM.
In vitro and in vivo evaluation of intravesical docetaxel loaded hydrophobically derivatized hyperbranched
polyglycerols in an orthotopic model of bladder cancer. Biomacromolecules. 2011;12:949-960
Muhammad O, Popescu A, Toms SA. Macrophage-mediated colocalization of quantum dots in experimental
glioma. Methods Mol Biol. 2007;374:161-171
Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, Hatanpaa KJ, Mickey B,
Madden C, Maher E, Boothman DA, Furnari F, Cavenee WK, Bachoo RM, Burma S. Egfrviii and DNA doubles t ran d b reak rep ai r: A mo l ecu l ar mech an i s m fo r rad i o res i s t an ce i n g l i o b l as t o ma. Ca n cer Res .
2009;69:4252-4259
Mulcahy H, O'Callaghan J, O'Grady EP, Macia MD, Borrell N, Gomez C, Casey PG, Hill C, Adams C, Gahan CG,
Oliver A, O'Gara F. Pseudomonas aeruginosa rsma plays an important role during murine infection by
influencing colonization, virulence, persistence, and pulmonary inflammation. Infect Immun. 2008;76:632-638
Muller O, Leuchs B, Pleger S, Grimm D, Franz W, Katus H, Kleinschmidt J. Improved cardiac gene transfer by
transcriptional and transductional targeting of adeno-associated viral vectors. Cardiovascular Research.
2006;70:70
Mumbengegwi DR, Li Q, Li C, Bear CE, Engelhardt JF. Evidence for a superoxide permeability pathway in
endosomal membranes. Mol Cell Biol. 2008;28:3700-3712
Mumprecht V, Honer M, Vigl B, Proulx ST, Trachsel E, Kaspar M, Banziger-Tobler NE, Schibli R, Neri D, Detmar
M. In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron
emission tomography. Cancer Res. 2010;70:8842-8851
Mundy R, MacDonald T, Dougan G, Frankel G, Wiles S. Citrobacter rodentium of mice and man. Cellular
Microbiology. 2005;7:1697-1706
Munguia A, Ota T, Miest T, Russell SJ. Cell carriers to deliver oncolytic viruses to sites of myeloma tumor
growth. Gene Ther. 2008;15:797-806
Murai K, Sakai D, Nakamura Y, Nakai T, Igarashi T, Seo N, Murakami T, Kobayashi E, Mochida J. Primary immune
system responders to nucleus pulposus cells: Evidence for immune response in disc herniation. Eur Cell Mater.
2010;19:13-21
Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang
ST. Immune evasion by murine melanoma mediated through cc chemokine receptor-10. Journal of Experimental
Medicine. 2003;198:1337-1347
Murakami T, Kobayashi E. Color-engineered rats and luminescent lacz imaging: A new platform to visualize
biological processes. Journal of biomedical optics. 2005;10:041204
Murakami T, Sato A, Chun NA, Hara M, Naito Y, Kobayashi Y, Kano Y, Ohtsuki M, Furukawa Y, Kobayashi E.
Transcriptional modulation using hdaci depsipeptide promotes immune cell-mediated tumor destruction of
murine b16 melanoma. J Invest Dermatol. 2008;128:1506-1516
Murohashi M, Hinohara K, Kuroda M, Isagawa T, Tsuji S, Kobayashi S, Umezawa K, Tojo A, Aburatani H, Gotoh N.
Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells. Br J
Cancer. 2010;102:206-212
Murphy CT, Moloney G, Hall LJ, Quinlan A, Faivre E, Casey P, Shanahan F, Melgar S, Nally K. Use of
bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis. Clinical and
experimental immunology. 2010;162:188-196
Murphy G, Mostoslavsky G, Kotton D, Mulligan R. Exogenous control of mammalian gene expression via
modulation of translational termination. Nature Medicine. 2006;12:1093-1099
Murray LJ, Abrams TJ, Long KR, Ngai TJ, Olson LM, Hong W, Keast PK, Brassard JA, O'Farrell AM, Cherrington
JM, Pryer NK. Su11248 inhibits tumor growth and csf-1r-dependent osteolysis in an experimental breast cancer
bone metastasis model. Clin Exp Metastasis. 2003;20:757-766
Mussi P, Liao L, Park SE, Ciana P, Maggi A, Katzenellenbogen BS, Xu J, O'Malley BW. Haploinsufficiency of the
corepressor of estrogen receptor activity (rea) enhances estrogen receptor function in the mammary gland.
Proceedings of the National Academy of Sciences of the United States of America. 2006;103:16716-16721
Mutnal MB, Hu S, Little MR, Lokensgard JR. Memory t cells persisting in the brain following mcmv infection
induce long-term microglial activation via interferon-gamma. Journal of neurovirology. 2011
1823.
1824.
1825.
1826.
1827.
1828.
1829.
1830.
1831.
1832.
1833.
1834.
1835.
1836.
1837.
1838.
1839.
1840.
1841.
1842.
1843.
1844.
1845.
Mwakingwe A, Ting LM, Hochman S, Chen J, Sinnis P, Kim K. Noninvasive real-time monitoring of liver-stage
development of bioluminescent plasmodium parasites. J Infect Dis. 2009;200:1470-1478
Na IK, Lu SX, Yim NL, Goldberg GL, Tsai J, Rao U, Smith OM, King CG, Suh D, Hirschhorn-Cymerman D, Palomba
L, Penack O, Holland AM, Jenq RR, Ghosh A, Tran H, Merghoub T, Liu C, Sempowski GD, Ventevogel M,
Beauchemin N, van den Brink MR. The cytolytic molecules fas ligand and trail are required for murine thymic
graft-versus-host disease. Journal of Clinical Investigation. 2010;120:343-356
Na IK, Markley JC, Tsai JJ, Yim NL, Beattie BJ, Klose AD, Holland AM, Ghosh A, Rao UK, Stephan MT, Serganova
I, Santos EB, Brentjens RJ, Blasberg RG, Sadelain M, van den Brink MR. Concurrent visualization of trafficking,
expansion, and activation of t lymphocytes and t-cell precursors in vivo. Blood. 2010;116:e18-25
Na K, Kim S, Sun BK, Woo DG, Yang HN, Chung HM, Park KH. Bioimaging of dexamethasone and tgf beta-1 and
its biological activities of chondrogenic differentiation in hydrogel constructs. J Biomed Mater Res A. 2008
Na K, Kim S, Woo D, Sun B, Yang H, Chung H, Park K. Synergistic effect of tgf [beta]-3 on chondrogenic
differentiation of rabbit chondrocytes in thermo-reversible hydrogel constructs blended with hyaluronic acid by
in vivo test. Journal of Biotechnology. 2007;128:412-422
Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Matsuo K, Arimori A, Isobe M, Tochigi S, Kondoh S, Hirai T,
Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y, Kamada H, Imazawa T, Itoh N,
Nakagawa S, Mayumi T, Tsunoda S, Tsutsumi Y. Systemic distribution, nuclear entry and cytotoxicity of
amorphous nanosilica following topical application. Biomaterials. 2011;32:2713-2724
Nadav L, Kalchenko V, Barak MM, Naparstek E, Geiger B, Katz BZ. The tumorigenic potential and disease
manifestations of malignant b-cell variants differing in their fibronectin adhesiveness. Experimental
Hematology. 2008;36:1524-1534
Nadella MVP, Kisseberth WC, Nadella KS, Thudi NK, Thamm DH, McNiel EA, Yilmaz A, Boris-Lawrie K, Rosol TJ.
Nod/scid mouse model of canine t-cell lymphoma with humoral hypercalcaemia of malignancy: Cytokine gene
expression profiling and in vivo bioluminescent imaging. Vet Comp Oncol. 2008;6:39-54
Nagamune K, Hicks LM, Fux B, Brossier F, Chini EN, Sibley LD. Abscisic acid controls calcium-dependent egress
and development in toxoplasma gondii. Nature. 2008;451:207-210
Nagashima K, Sasseville VG, Wen D, Bielecki A, Yang H, Simpson C, Grant E, Hepperle M, Harriman G, Jaffee B,
Ocain T, Xu Y, Fraser CC. Rapid tnfr1-dependent lymphocyte depletion in vivo with a selective chemical
inhibitor of ikkbeta. Blood. 2006;107:4266-4273
Naik S, Piwnica-Worms D. Real-time imaging of beta-catenin dynamics in cells and living mice. Proceedings of
the National Academy of Sciences of the United States of America. 2007;104:17465
Naik S, Piwnica-Worms D. Real-time imaging of β-catenin dynamics in cells and living mice. Proceedings of the
National Academy of Sciences of the United States of America. 2007;104:17465-17470
Najy AJ, Day KC, Day ML. Adam15 supports prostate cancer metastasis by modulating tumor cell-endothelial
cell interaction. Cancer Res. 2008;68:1092-1099
Nakai H, Fuess S, Storm T, Meuse L, Kay M. Free DNA ends are essential for concatemerization of synthetic
double-stranded adeno-associated virus vector genomes transfected into mouse hepatocytes in vivo. Molecular
Therapy. 2003;7:112-121
Nakajima A, Kamijo S, Yoshioka T. Visualization of antigen-specific t cell in living arthritic mice. J Nippon Med
Sch. 2006;73:298-299
Nakajima A, Seroogy CM, Sandora MR, Tarner IH, Costa GL, Taylor-Edwards C, Bachmann MH, Contag CH,
Fathman CG. Antigen-specific t cell-mediated gene therapy in collagen-induced arthritis. J Clin Invest.
2001;107:1293-1301
Nakajima TE, Yanagihara K, Takigahira M, Yasunaga M, Kato K, Hamaguchi T, Yamada Y, Shimada Y, Mihara K,
Ochiya T, Matsumura Y. Antitumor effect of sn-38-releasing polymeric micelles, nk012, on spontaneous
peritoneal metastases from orthotopic gastric cancer in mice compared with irinotecan. Cancer Res.
2008;68:9318-9322
Nakamura Y, Miyata M, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A. House dust mite
allergen der f 1 can induce the activation of latent tgf-beta via its protease activity. FEBS Lett.
2009;583:2088-2092
Nakano Y, Longo-Guess CM, Bergstrom DE, Nauseef WM, Jones SM, Bánfi B. Mutation of the cyba gene
encoding p22phox causes vestibular and immune defects in mice. Journal of Clinical Investigation.
2008;118:1176-1185
Namgung R, Nam S, Kim SK, Son S, Singha K, Kwon JS, Ahn Y, Jeong MH, Park IK, Garripelli VK, Jo S, Kim WJ.
An acid-labile temperature-responsive sol-gel reversible polymer for enhanced gene delivery to the myocardium
and skeletal muscle cells. Biomaterials. 2009;30:5225-5233
Nantz M, Dicus C, Hilliard B, Yellayi S, Zou S, Hecker J. The benefit of hydrophobic domain asymmetry on the
efficacy of transfection as measured by in vivo imaging. Molecular Pharmaceutics. 2010;7:786-794
Nardinocchi L, Pantisano V, Puca R, Porru M, Aiello A, Grasselli A, Leonetti C, Safran M, Rechavi G, Givol D,
Farsetti A, D'Orazi G. Zinc downregulates hif-1α and inhibits its activity in tumor cells in vitro and in vivo PloS
ONE. 2010
Narla G, DiFeo A, Fernandez Y, Dhanasekaran S, Huang F, Sangodkar J, Hod E, Leake D, Friedman SL, Hall SJ,
Chinnaiyan AM, Gerald WL, Rubin MA, Martignetti JA. Klf6-sv1 overexpression accelerates human and mouse
prostate cancer progression and metastasis. Journal of Clinical Investigation. 2008;118:2711-2721
1846.
1847.
1848.
1849.
1850.
1851.
1852.
1853.
1854.
1855.
1856.
1857.
1858.
1859.
1860.
1861.
1862.
1863.
1864.
1865.
1866.
1867.
1868.
1869.
1870.
Narsinh KH, Cao F, Wu JC. Application of reporter gene imaging for studying human embryonic stem cells in
living subjects. Viral applications of green fluorescent protein. 2009:13-32.
Nasr R, Guillemin MC, Ferhi O, Soilihi H, Peres L, Berthier C, Rousselot P, Robledo-Sarmiento M, LallemandBreitenbach V, Gourmel B, Vitoux D, Pandolfi PP, Rochette-Egly C, Zhu J, de The H. Eradication of acute
promyelocytic leukemia-initiating cells through pml-rara degradation. Nat Med. 2008;14:1333-1342
Nathan C, Amirghahari N, Rong X, Sibley D. Bioluminescence tracks the in vivo effects of cci-779 in a minimal
residual disease model of hnscc. Proceedings of the American Association for Cancer Research.
2006;2006:1049
Nathan CA, Amirghahari N, Rong X, Giordano T, Sibley D, Nordberg M, Glass J, Agarwal A, Caldito G. Mammalian
target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck
squamous cell cancer. Cancer Res. 2007;67:2160-2168
Naumann EA, Kampff AR, Prober DA, Schier AF, Engert F. Monitoring neural activity with bioluminescence
during natural behavior. Nature Neuroscience. 2010;13:513-520
Navaraj A, Finnberg N, Dicker DT, Yang W, Matthew EM, El-Deiry WS. Reduced cell death, invasive and
angiogenic features conferred by brca1-deficiency in mammary epithelial cells transformed with h-ras. Cancer
Biol Ther. 2009;8:2417-2444
Nawotka KA, Doyle TC, Francis KP, Korde KM, Yu MC, Bellinger-Kawahara C, Purchio AF, Contag PR. A sepsis
model of candida albicans infection using bioluminescent cells. Abstracts of the General Meeting of the
American Society for Microbiology. 2001;101:382
Neal RE, 2nd, Singh R, Hatcher HC, Kock ND, Torti SV, Davalos RV. Treatment of breast cancer through the
application of irreversible electroporation using a novel minimally invasive single needle electrode. Breast
Cancer Res Treat. 2010;123:295-301
Neben T, Clermont A, Esposito L, Oei Y, Jenkins D. Luciferase expressing lovo-6-luc-1 human colon cancer cells
used to monitor tumor growth and metastasis in vivo in scid-bg mice. Proceedings of the American Association
for Cancer Research. 2005;2005:908
Neff BA, Voss SG, Allen C, Schroeder MA, Driscoll CL, Link MJ, Galanis E, Sarkaria JN. Bioluminescent imaging
of intracranial vestibular schwannoma xenografts in nod/scid mice. Otol Neurotol. 2009;30:105-111
Negishi Y, Matsuo K, Endo-Takahashi Y, Suzuki K, Matsuki Y, Takagi N, Suzuki R, Maruyama K, Aramaki Y.
Delivery of an angiogenic gene into ischemic muscle by novel bubble liposomes followed by ultrasound
exposure. Pharmaceutical Research. 2010:1-8
Negishi Y, Tsunoda Y, Endo-Takahashi Y, Oda Y, Suzuki R, Maruyama K, Yamamoto M, Aramaki Y. Local gene
delivery system by bubble liposomes and ultrasound exposure into joint synovium. Journal of drug delivery.
2011;2011:203986
Negrin RS, Contag CH. In vivo imaging using bioluminescence: A tool for probing graft-versus-host disease.
Nat Rev Immunol. 2006;6:484-490
Nelson TJ, Martinez-Fernandez A, Yamada S, Perez-Terzic C, Ikeda Y, Terzic A. Repair of acute myocardial
infarction by human stemness factors induced pluripotent stem cells. Circulation. 2009;120:408-416
Nemeth K, Federico S, Carcaboso A, Shen Y, Schaiquevich P, Zhang J, Egorin M, Stewart C, Dyer M.
Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma. Cancer.
2010
Nervi B, Ramirez P, Rettig MP, Uy GL, Holt MS, Ritchey JK, Prior JL, Piwnica-Worms D, Bridger G, Ley TJ,
DiPersio JF. Chemosensitization of acute myeloid leukemia (aml) following mobilization by the cxcr4
antagonist amd3100. Blood. 2009;113:6206-6214
Nervi B, Rettig MP, Ritchey JK, Wang HL, Bauer G, Walker J, Bonyhadi ML, Berenson RJ, Prior JL, PiwnicaWorms D, Nolta JA, Dipersio JF. Factors affecting human t cell engraftment, trafficking, and associated
xenogeneic graft-vs-host disease in nod/scid beta2m(null) mice. Exp Hematol. 2007
Nesbitt A, Eddleston A, Marenzana M, Marshall D. Comparison of the distribution of an igg and a pegylated fab'
form of an anti-tnf-alpha antibody in the inflamed gut of colitic mice. American Journal of Gastroenterology.
2009;104:S440-S441
Neuhaus K, Anastasov N, Kaberdin V, Francis KP, Miller VL, Scherer S. The aguaaa motif in cspa1/a2 mrna is
important for adaptation of yersinia enterocolitica to grow at low temperature. Molecular Microbiology.
2003;50:1629-1645
Neuhaus K, Francis KP, Rapposch S, Görg A, Scherer S. Pathogenic yersinia species carry a novel, cold-inducible
major cold shock protein tandem gene duplication producing both bicistronic and monocistronic mrna. Journal
of Bacteriology. 1999;181:6449-6455
Neuhaus K, Rapposch S, Francis KP, Scherer S. Restart of exponential growth of cold-shocked yersinia
enterocolitica occurs after down-regulation of cspa1/a2 mrna. Journal of Bacteriology. 2000;182:3285-3288
Neves AA, Stöckmann H, Harmston RR, Pryor HJ, Alam IS, Ireland-Zecchini H, Lewis DY, Lyons SK, Leeper FJ,
Brindle KM. Imaging sialylated tumor cell glycans in vivo. The FASEB Journal. 2011
Newton JR, Kelly KA, Mahmood U, Weissleder R, Deutscher SL. In vivo selection of phage for the optical
imaging of pc-3 human prostate carcinoma in mice1. Neoplasia. 2006;8:772-780
Ng K, Nitta M, Hu L, Kesari S, Kung A, D’Andrea A, Chen C. A small interference rna screen revealed proteasome
inhibition as strategy for glioblastoma therapy. Clinical Neurosurgery. 2009;56:107
Ng KP, Ebrahem Q, Negrotto S, Mahfouz RZ, Link KA, Hu Z, Gu X, Advani A, Kalaycio M, Sobecks R, Sekeres M,
1871.
1872.
1873.
1874.
1875.
1876.
1877.
1878.
1879.
1880.
1881.
1882.
1883.
1884.
1885.
1886.
1887.
1888.
1889.
1890.
1891.
1892.
Copelan E, Radivoyevitch T, Maciejewski J, Mulloy JC, Saunthararajah Y. P53 independent epigeneticdifferentiation treatment in xenotransplant models of acute myeloid leukemia. Leukemia : official journal of the
Leukemia Society of America, Leukemia Research Fund, U.K. 2011
Nguyen AT, Dow AC, Kupiec-Weglinski J, Busuttil RW, Lipshutz GS. Evaluation of gene promoters for liver
expression by hydrodynamic gene transfer. J Surg Res. 2008;148:60-66
Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massagué J. Wnt/tcf signaling
through lef1 and hoxb9 mediates lung adenocarcinoma metastasis. Cell. 2009;138:51-62
Nguyen Huu S, Oster M, Uzan S, Chareyre F, Aractingi S, Khosrotehrani K. Maternal neoangiogenesis during
pregnancy partly derives from fetal endothelial progenitor cells. Proceedings of the National Academy of
Sciences of the United States of America. 2007;104:1871-1876
Nguyen T, Dai Y, Attkisson E, Kramer L, Jordan N, Nguyen N, Kolluri N, Muschen M, Grant S. Hdac inhibitors
potentiate the activity of the bcr/abl kinase inhibitor kw-2449 in imatinib-sensitive or -resistant bcr/abl+
leukemia cells in vitro and in vivo. Clinical cancer research : an official journal of the American Association
for Cancer Research. 2011;17:3219-3232
Nguyên TLA, Abdelbary H, Arguello M, Breitbach C, Leveille S, Diallo JS, Yasmeen A, Bismar TA, Kirn D, Falls T,
Snoulten VE, Vanderhyden BC, Werier J, Atkins H, Vähä-Koskela MJV, Stojdl DF, Bell JC, Hiscott J. Chemical
targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to
viral oncolysis. Proceedings of the National Academy of Sciences of the United States of America.
2008;105:14981-14986
Nguyen V, Zeiser R, daSilva D, Chang D, Beilhack A, Contag C, Negrin R. In vivo dynamics of regulatory t-cell
trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic
transplantation. Blood. 2007;109:2649
Nguyen VH, Kim HS, Ha JM, Hong Y, Choy HE, Min JJ. Genetically engineered salmonella typhimurium as an
imageable therapeutic probe for cancer. Cancer Res. 2010;70:18-23
Ni J, Nolte B, Arnold A, Fournier P, Schirrmacher V. Targeting anti-tumor DNA vaccines to dendritic cells via a
short cd11c promoter sequence. Vaccine. 2009;27:5480-5487
Nickels M, Xie J, Cobb J, Gore JC, Pham W. Functionalization of iron oxide nanoparticles with a versatile epoxy
amine linker. J Mater Chem. 2010;20:4776-4780
Nicoud I, Jones C, Pierce J, Earl T, Matrisian L, Chari R, Gorden D. Warm hepatic ischemia-reperfusion promotes
growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction. Cancer
Res. 2007;67:2720
Nie CQ, Bernard NJ, Norman MU, Amante FH, Lundie RJ, Crabb BS, Heath WR, Engwerda CR, Hickey MJ,
Schofield L, Hansen DS. Ip-10-mediated t cell homing promotes cerebral inflammation over splenic immunity to
malaria infection. PLoS Pathog. 2009;5
Niel L, Shah AH, Lewis GA, Mo K, Chatterjee D, Fernando SM, Hong MH, Chang WY, Vollmayr P, Rosen J, Miner
JN, Monks DA. Sexual differentiation of the spinal nucleus of the bulbocavernosus is not mediated solely by
androgen receptors in muscle fibers. Endocrinology. 2009;150:3207-3213
Niers TM, Bruggemann LW, Klerk CP, Muller FJ, Buckle T, Reitsma PH, Richel DJ, Spek CA, Van Tellingen O, Van
Noorden CJ. Differential effects of anticoagulants on tumor development of mouse cancer cell lines b16, k1735
and ct26 in lung. Clin Exp Metastasis. 2009;26:171-178
Nijnik A, Madera L, Ma S, Waldbrook M, Elliott MR, Easton DM, Mayer ML, Mullaly SC, Kindrachuk J, Jenssen
H, Hancock RE. Synthetic cationic peptide idr-1002 provides protection against bacterial infections through
chemokine induction and enhanced leukocyte recruitment. J Immunol. 2010;184:2539-2550
Nishii R, Volgin AY, Mawlawi O, Mukhopadhyay U, Pal A, Bornmann W, Gelovani JG, Alauddin MM. Evaluation
of 2'-deoxy-2'-[18f]fluoro-5-methyl-1-beta-l: -arabinofuranosyluracil ([18f]-l: -fmau) as a pet imaging agent for
cellular proliferation: Comparison with [18f]-d: -fmau and [18f]flt. Eur J Nucl Med Mol Imaging.
2008;35:990-998
Nishijo K, Hosoyama T, Bjornson CRR, Schaffer BS, Prajapati SI, Bahadur AN, Hansen MS, Blandford MC,
McCleish AT, Rubin BP, Epstein JA, Rando TA, Capecchi MR, Keller C. Biomarker system for studying muscle,
stem cells, and cancer in vivo. FASEB Journal. 2009;23:2681-2690
Nishimura R, Baker J, Beilhack A, Zeiser R, Olson JA, Sega EI, Karimi M, Negrin RS. In vivo trafficking and
survival of cytokine-induced killer cells resulting in minimal gvhd with retention of antitumor activity. Blood.
2008;112:2563-2574
Nishiyabu R, Hashimoto N, Cho T, Watanabe K, Yasunaga T, Endo A, Kaneko K, Niidome T, Murata M, Adachi C,
Katayama Y, Hashizume M, Kimizuka N. Nanoparticles of adaptive supramolecular networks self-assembled from
nucleotides and lanthanide ions. J Am Chem Soc. 2009;131:2151-2158
Nissen LJ, Cao R, Hedlund EM, Wang Z, Zhao X, Wetterskog D, Funa K, Bråkenhielm E, Cao Y. Angiogenic factors
fgf2 and pdgf-bb synergistically promote murine tumor neovascularization and metastasis. Journal of Clinical
Investigation. 2007;117:2766-2777
Niu G, Xiong Z, Cheng Z, Cai W, Gambhir SS, Xing L, Chen X. In vivo bioluminescence tumor imaging of rgd
peptide-modified adenoviral vector encoding firefly luciferase reporter gene. Mol Imaging Biol. 2007;9:126-134
Nogawa M, Yuasa T, Kimura S, Kuroda J, Sato K, Segawa H, Yokota A, Maekawa T. Monitoring luciferase-labeled
cancer cell growth and metastasis in different in vivo models. Cancer Lett. 2005;217:243-253
Nogawa M, Yuasa T, Kimura S, Tanaka M, Kuroda J, Sato K, Yokota A, Segawa H, Toda Y, Kageyama S, Yoshiki T,
1893.
1894.
1895.
1896.
1897.
1898.
1899.
1900.
1901.
1902.
1903.
1904.
1905.
1906.
1907.
1908.
1909.
1910.
1911.
1912.
1913.
1914.
1915.
Okada Y, Maekawa T. Intravesical administration of small interfering rna targeting plk-1 successfully prevents
the growth of bladder cancer. Journal of Clinical Investigation. 2005;115:978-985
Nomikou N, McHale A. Expression of a minicircle-encoded transgene in vivo following ultrasound-mediated
transfection (sonoporation). Human Gene Therapy. 2009;20:1516
Nordone SK, Ignacio GA, Su L, Sempowski GD, Golenbock DT, Li L, Dean GA. Failure of tlr4-driven nf-kappa b
activation to stimulate virus replication in models of hiv type 1 activation. AIDS Res Hum Retroviruses.
2007;23:1387-1395
Notebaert S, Carlsen H, Janssen D, Vandenabeele P, Blomhoff R, Meyer E. In vivo imaging of nf-kappab activity
during escherichia coli-induced mammary gland infection. Cell Microbiol. 2008;10:1249-1258
Notting IC, Buijs JT, Que I, Mintardjo RE, van der Horst G, Karperien M, Missotten GS, Jager MJ, Schalij-Delfos
NE, Keunen JE, van der Pluijm G. Whole-body bioluminescent imaging of human uveal melanoma in a new
mouse model of local tumor growth and metastasis. Invest Ophthalmol Vis Sci. 2005;46:1581-1587
Novotny LA, Mason KM, Bakaletz LO. Development of a chinchilla model to allow direct, continuous,
biophotonic imaging of bioluminescent nontypeable haemophilus influenzae during experimental otitis media.
Infection and Immunity. 2005;73:609-611
Numbenjapon T, Wang J, Colcher D, Schluep T, Davis ME, Duringer J, Kretzner L, Yen Y, Forman SJ, Raubitschek
A. Preclinical results of camptothecin-polymer conjugate (it-101) in multiple human lymphoma xenograft
models. Clin Cancer Res. 2009;15:4365-4373
Numbenjapon T, Wang J, Colcher D, Schluep T, Forman SJ, Raubitschek A. Preclinical efficacy of campthothecinpolymer conjugate (it-101) in human burkitt lymphoma bearing mice. Blood. 2006;108:705A
Nyati S, Ranga R, Ross BD, Rehemtulla A, Bhojani MS. Molecular imaging of glycogen synthase kinase-3beta
and casein kinase-1alpha kinases. Analytical biochemistry. 2010;405:246-254
Nykanen A, Pajusola K, Krebs R, Keranen M, Raisky O, Koskinen P, Alitalo K, Lemstrom K. Common protective
and diverse smooth muscle cell effects of aav-mediated angiopoietin-1 and-2 expression in rat cardiac allograft
vasculopathy. Circulation Research. 2006;98:1373
O'Connell RM, Balazs AB, Rao DS, Kivork C, Yang L, Baltimore D. Lentiviral vector delivery of human
interleukin-7 (hil-7) to human immune system (his) mice expands t lymphocyte populations. PLoS One. 2010;5
O'Connell-Rodwell CE, Mackanos MA, Simanovskii D, Cao YA, Bachmann MH, Schwettman HA, Contag CH. In
vivo analysis of heat-shock-protein-70 induction following pulsed laser irradiation in a transgenic reporter
mouse. J Biomed Opt. 2008;13:030501
O'Connell-Rodwell CE, Shriver D, Simanovskii DM, McClure C, Cao YA, Zhang W, Bachmann MH, Beckham JT,
Jansen ED, Palanker D, Schwettman HA, Contag CH. A genetic reporter of thermal stress defines physiologic
zones over a defined temperature range. FASEB Journal. 2004;18:264-271
O'Hara AM, O'Regan P, Fanning Á, O'Mahony C, MacSharry J, Lyons A, Bienenstock J, O'Mahony L, Shanahan F.
Functional modulation of human intestinal epithelial cell responses by bifidobacterium infantis and
lactobacillus salivarius. Immunology. 2006;118:202-215
O'Mahony C, Scully P, O'Mahony D, Murphy S, O'Brien F, Lyons A, Sherlock G, MacSharry J, Kiely B, Shanahan
F, O'Mahony L. Commensal-induced regulatory t cells mediate protection against pathogen-stimulated nfkappab activation. PLoS Pathog. 2008;4:e1000112
O'Mahony C, van der Kleij HP, Bienenstock J, Shanahan F, O'Mahony L. Loss of vagal anti-inflammatory effect in vivo visualization and adoptive transfer. Am J Physiol Regul Integr Comp Physiol. 2009
O'Toole SA, Machalek DA, Shearer RF, Millar EK, Nair R, Schofield P, McLeod D, Cooper CL, McNeil CM,
McFarland A, Nguyen A, Ormandy CJ, Qiu MR, Rabinovich B, Martelotto LG, Vu D, Hannigan GE, Musgrove EA,
Christ D, Sutherland RL, Watkins DN, Swarbrick A. Hedgehog overexpression is associated with stromal
interactions and predicts for poor outcome in breast cancer. Cancer Res. 2011;71:4002-4014
Oakley F, Smith R, Engelhardt J. Lipid rafts and caveolin-1 coordinate interleukin-1 (il-1 )-dependent activation
of nf b by controlling endocytosis of nox2 and il-1 receptor 1 from the plasma membrane. Journal of Biological
Chemistry. 2009;284:33255
Ocio EM, Vilanova D, Atadja P, Maiso P, Crusoe E, Fernández-Lázaro D, Garayoa M, San-Segundo L, HernándezIglesias T, de Álava E, Shao W, Yao YM, Pandiella A, San-Miguel JF. In vitro and in vivo rationale for the triple
combination of panobinostat (lbh589) and dexamethasone with either bortezomib or lenalidomide in multiple
myeloma. Haematologica. 2010;95:794-803
Ogata Y, Fujishiro J, Kawana H, Kobayashi E. Adenovirus-mediated gene transfer to the rat heart graft.
Transplantation. 2004;78:1408
Ogunniyi AD, Paton JC, Kirby AC, McCullers JA, Cook J, Hyodo M, Hayakawa Y, Karaolis DK. C-di-gmp is an
effective immunomodulator and vaccine adjuvant against pneumococcal infection. Vaccine. 2008;26:4676-4685
Ogura T, Mizukami H, Mimuro J, Madoiwa S, Okada T, Matsushita T, Urabe M, Kume A, Hamada H, Yoshikawa H.
Utility of intraperitoneal administration as a route of aav serotype 5 vector-mediated neonatal gene transfer. The
Journal of Gene Medicine. 2006;8:990-997
Oh S, Stish BJ, Sachdev D, Chen H, Dudek AZ, Vallera DA. A novel “reduced immunogenicity” bispecific targeted
toxin simultaneously recognizing human egf and il-4 receptors in a mouse model of metastatic breast carcinoma.
Clinical Cancer Research. 2009;15:6137-6147
Oh S, Tsai AK, Ohlfest JR, Panoskaltsis-Mortari A, Vallera DA. Evaluation of a bispecific biological drug
designed to simultaneously target glioblastoma and its neovasculature in the brain. Journal of neurosurgery.
1916.
1917.
1918.
1919.
1920.
1921.
1922.
1923.
1924.
1925.
1926.
1927.
1928.
1929.
1930.
1931.
1932.
1933.
1934.
1935.
1936.
1937.
1938.
1939.
1940.
1941.
1942.
2011;114:1662-1671
Ohlfest JR, Demorest ZL, Motooka Y, Vengco I, Oh S, Chen E, Scappaticci FA, Saplis RJ, Ekker SC, Low WC.
Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the sleeping beauty transposon
causes tumor regression and improves survival in mice bearing intracranial human glioblastoma. Molecular
Therapy. 2005;12:778-788
Ohlfest JR, Lobitz PD, Perkinson SG, Largaespada DA. Integration and long-term expression in xenografted
human glioblastoma cells using a plasmid-based transposon system. Mol Ther. 2004;10:260-268
Ohsawa I, Uemoto S, Kobayashi E, Murakami T. Control of cyclosporine a-induced tumor progression using 15deoxyspergualin for rat cardiac transplantation. Transplantation. 2007;84:424
Ohsawa I MT, Uemoto S, Kobayashi E. In vivo luminescent imaging of cyclosporin a-mediated cancer
progression in rats. Transplantation. 2006;81:1558-1567
Ojogho O, Li A, Zuppan CW, Escher A. Bioluminescent mammalian cells grown in sponge matrices to monitor
immune rejection. Mol Imaging. 2007;6:323-330
Okada S, Ishii K, Yamane J, Iwanami A, Ikegami T, Katoh H, Iwamoto Y, Nakamura M, Miyoshi H, Okano H. In
vivo imaging of engrafted neural stem cells: Its application in evaluating the optimal timing of transplantation
for spinal cord injury. The FASEB Journal. 2005:05
Okada T, Uchibori R, Iwata-Okada M, Takahashi M, Nomoto T, Nonaka-Sarukawa M, Ito T, Liu Y, Mizukami H,
Kume A. A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene
expression in tumor cells. Molecular Therapy. 2006;13:738-746
Okamura N, Mori M, Furumoto S, Yoshikawa T, Harada R, Ito S, Fujikawa Y, Arai H, Yanai K, Kudo Y. In vivo
detection of amyloid plaques in the mouse brain using the near-infrared fluorescence probe thk-265. J
Alzheimers Dis. 2011;23:37-48
Olson J, Leveson-Gower D, Gill S, Baker J, Beilhack A, Negrin R. Nk cells mediate reduction of gvhd by
inhibiting activated, alloreactive t cells while retaining gvt effects. Blood. 2010;115:4293
Olson JA, Zeiser R, Beilhack A, Goldman JJ, Negrin RS. Tissue-specific homing and expansion of donor nk cells
in allogeneic bone marrow transplantation. J Immunol. 2009;183:3219-3228
Oltean S, Febbo PG, Garcia-Blanco MA. Dunning rat prostate adenocarcinomas and alternative splicing reporters:
Powerful tools to study epithelial plasticity in prostate tumors in vivo. Clinical and Experimental Metastasis.
2008;25:611-619
Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N,
Byrd JC, Kulp SK, Chen CS. Antitumor effects of osu-2s, a nonimmunosuppressive analogue of fty720, in
hepatocellular carcinoma. Hepatology. 2011;53:1943-1958
Omar HA, Sargeant AM, Weng JR, Wang D, Kulp SK, Patel T, Chen CS. Targeting of the akt-nuclear factor-κb
signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1h-indol-3-yl]-methanol (osu-a9), a novel indole-3carbinol derivative, in a mouse model of hepatocellular carcinoma. Molecular Pharmacology. 2009;76:957-968
Ong H, Hasegawa K, Dietz A, Russell S, Peng K. Evaluation of t cells as carriers for systemic measles virotherapy
in the presence of antiviral antibodies. Gene Therapy. 2006;14:324-333
Ong HT, Trejo TR, Pham LD, Oberg AL, Russell SJ, Peng KW. Intravascularly administered rgd-displaying
measles viruses bind to and infect neovessel endothelial cells in vivo. Mol Ther. 2009;17:1012-1021
Ong S, Li F, Du J, Tan Y, Wang S. Hybrid cytomegalovirus enhancer-h1 promoter-based plasmid and baculovirus
vectors mediate effective rna interference. Human Gene Therapy. 2005;16:1404-1412
Ophir E, Eidelstein Y, Afik R, Bachar-Lustig E, Reisner Y. Induction of tolerance to bone marrow allografts by
donor-derived host nonreactive ex vivo-induced central memory cd8 t cells. Blood. 2010;115:2095-2104
Orihuela C, Tuomanen E. Models of pneumococcal disease. Drug Discovery Today: Disease Models.
2006;3:69-75
Orihuela CJ, Fillon S, Smith-Sielicki SH, El Kasmi KC, Gao G, Soulis K, Patil A, Murray PJ, Tuomanen EI. Cell
wall-mediated neuronal damage in early sepsis. Infection and Immunity. 2006;74:3783-3789
Orihuela CJ, Gao G, Francis KP, Yu J, Tuomanen EI. Tissue-specific contributions of pneumococcal virulence
factors to pathogenesis. Journal of Infectious Diseases. 2004;190:1661-1669
Orihuela CJ, Gao G, McGee M, Yu J, Francis KP, Tuomanen E. Organ-specific models of streptococcus
pneumoniae disease. Scandinavian Journal of Infectious Diseases. 2003;35:647-652
Orihuela CJ, Radin JN, Sublett JE, Gao G, Kaushal D, Tuomanen EI. Microarray analysis of pneumococcal gene
expression during invasive disease. Infection and Immunity. 2004;72:5582-5596
Ortiz-Abalia J, Sahún I, Altafaj X, Andreu N, Estivill X, Dierssen M, Fillat C. Targeting dyrk1a with aavshrna
attenuates motor alterations in tgdyrk1a, a mouse model of down syndrome. American Journal of Human
Genetics. 2008;83:479-488
Osborn M, Panoskaltsis-Mortari A, McElmurry R, Bell S, Vignali D, Ryan M, Wilber A, McIvor R, Tolar J, Blazar
B. A picornaviral 2a-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression
coupled to a dual-reporter system. Molecular Therapy. 2005;12:569-574
Osborn MJ, McElmurry RT, Peacock B, Tolar J, Blazar BR. Targeting of the cns in mps-ih using a nonviral
transferrin-α-l-iduronidase fusion gene product. Mol Ther. 2008;16:1459-1466
Osborne C, Moffat A, Dean C, Woods A, Caughlan R, Growcott E, Banner K. The use of in vivo imaging
technology to determine compound efficacy in a mouse lung infection model. pA2 Online. 2009;7
Osorio JE, Iams K, Meteyer C, Rocke T. Comparison of monkeypox viruses pathogenesis in mice by in vivo
1943.
1944.
1945.
1946.
1947.
1948.
1949.
1950.
1951.
1952.
1953.
1954.
1955.
1956.
1957.
1958.
1959.
1960.
1961.
1962.
1963.
1964.
1965.
1966.
imaging. PLoS ONE. 2009
Otto-Duessel M, Khankaldyyan V, Gonzalez-Gomez I, Jensen MC, Laug WE, Rosol M. In vivo testing of renilla
luciferase substrate analogs in an orthotopic murine model of human glioblastoma. Mol Imaging. 2006;5:57-64
Ottobrini L, Ciana P, Moresco R, Lecchi M, Belloli S, Martelli C, Todde S, Fazio F, Gambhir SS, Maggi A,
Lucignani G. Development of a bicistronic vector for multimodality imaging of estrogen receptor activity in a
breast cancer model: Preliminary application. Eur J Nucl Med Mol Imaging. 2008;35:365-378
Ou G, Itasaka S, Zeng L, Shibuya K, Yi J, Harada H, Hiraoka M. Usefulness of hif-1 imaging for determining
optimal timing of combining bevacizumab and radiotherapy. Int J Radiat Oncol Biol Phys. 2009;75:463-467
Ou-Yang F, Lan K-L, Chen C-T, Liu J-C, Weng C-L, Chou C-K, Xie X, Hung J-Y, Wei Y, Hortobagyi GN, Hung M-C.
Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial
cells. Cancer Res. 2006;66:378-384
Owen SJ, Batzloff M, Chehrehasa F, Meedeniya A, Casart Y, Logue CA, Hirst RG, Peak IR, Mackay-Sim A, Beacham
IR. Nasal-associated lymphoid tissue and olfactory epithelium as portals of entry for burkholderia pseudomallei
in murine melioidosis. J Infect Dis. 2009;199:1761-1770
Ozawa T, James CD. Establishing intracranial brain tumor xenografts with subsequent analysis of tumor growth
and response to therapy using bioluminescence imaging. J Vis Exp. 2010:e1986
P. Raikwar S, Zavazava N. Real-time non-invasive imaging of es cell-derived insulin producing cells. Molecular
endocrinology. 2009:317-334.
Paar M, Schwab S, Rosenfellner D, Salmons B, Günzburg WH, Renner M, Portsmouth D. Effects of viral strain,
transgene position, and target cell type on replication kinetics, genomic stability, and transgene expression of
replication-competent murine leukemia virus-based vectors▿. J Virol. 2007;81:6973-6983
Padmanabhan P, Otero J, Ray P, Paulmurugan R, Hoffman AR, Gambhir SS, Biswal S, Ulaner GA. Visualization of
telomerase reverse transcriptase (htert) promoter activity using a trimodality fusion reporter construct. J Nucl
Med. 2006;47:270-277
Pagel JM, Matthews DC, Kenoyer A, Hamlin DK, Wilbur DS, Fisher DR, Gopal AK, Lin Y, Saganic L, Appelbaum
FR, Press OW. Pretargeted radioimmunotherapy using anti-cd45 monoclonal antibodies to deliver radiation to
murine hematolymphoid tissues and human myeloid leukemia. Cancer Res. 2009;69:185-192
Pagel M, Baldwin S, Rader R, Kotyk J. Assessment of anti metastatic drug efficacy via localization and
quantification of ex vivo murine bone tumor load using high throughput mri t1 parametric analysis. NMR in
Biomedicine. 2006;19:1-9
Pajusola K, Kunnapuu J, Vuorikoski S, Soronen J, Andre H, Pereira T, Korpisalo P, Yla-Herttuala S, Poellinger L,
Alitalo K. Stabilized hif-1 is superior to vegf for angiogenesis in skeletal muscle via adeno-associated virus gene
transfer. The FASEB Journal. 2005;19:1365-1367
Palanker D, Chalberg T, Vankov A, Huie P, Molnar F, Butterwick A, Calos M, Marmor M, Blumenkranz M. Plasmamediated transfection of rpe. Proc spie ophthalmic technol. 2006:1-9.
Paleari L, Negri E, Catassi A, Cilli M, Servent D, D'Angelillo R, Cesario A, Russo P, Fini M. Inhibition of
nonneuronal alpha7-nicotinic receptor for lung cancer treatment. Am J Respir Crit Care Med.
2009;179:1141-1150
Palframan R, Airey M, Moore A, Vugler A, Nesbitt A. Use of biofluorescence imaging to compare the distribution
of certolizumab pegol, adalimumab, and infliximab in the inflamed paws of mice with collagen-induced arthritis.
Journal of Immunological Methods. 2009;348:36-41
Palmer KL, Aye LM, Whiteley M. Nutritional cues control pseudomonas aeruginosa multicellular behavior in
cystic fibrosis sputum▿†. Journal of Bacteriology. 2007;189:8079-8087
Pan H, Myerson JW, Ivashyna O, Soman NR, Marsh JN, Hood JL, Lanza GM, Schlesinger PH, Wickline SA. Lipid
membrane editing with peptide cargo linkers in cells and synthetic nanostructures. Faseb J. 2010;24:2928-2937
Pan MH, Gao DW, Feng J, He J, Seo Y, Tedesco J, Wolodzko JG, Hasegawa BH, Franc BL. Biodistributions of
177lu- and 111in- labeled 7e11 antibodies to prostate-specific membrane antigen in xenograft model of prostate
cancer and potential use of 111in-7e11 as a pretherapeutic agent for 177lu-7e11 radioimmunotherapy. Mol
Imaging Biol. 2009;11:159-166
Pan X, Arumugam T, Yamamoto T, Levin PA, Ramachandran V, Ji B, Lopez-Berestein G, Vivas-Mejia PE, Sood AK,
McConkey DJ, Logsdon CD. Nuclear factor-kappab p65/rela silencing induces apoptosis and increases
gemcitabine effectiveness in a subset of pancreatic cancer cells. Clin Cancer Res. 2008;14:8143-8151
Pandit S, Khaibullina A, Burr M, Li K. Targeted in-vivo delivery of genes using high intensity focused
ultrasound (hifu). Proceedings of the American Association for Cancer Research. 2004;2004:212
Paneda A, Vanrell L, Mauleon I, Crettaz JS, Berraondo P, Timmermans EJ, Beattie SG, Twisk J, van Deventer S,
Prieto J, Fontanellas A, Rodriguez-Pena MS, Gonzalez-Aseguinolaza G. Effect of adeno-associated virus serotype
and genomic structure on liver transduction and biodistribution in mice of both genders. Hum Gene Ther.
2009;20:908-917
Pang Z, Wu N, Zhang X, Avallone R, Croci T, Dressler H, Palejwala V, Ferrara P, Tocci M, Polites H. Gpr40 is
partially required for insulin secretion following activation of [beta] 3-adrenergic receptors. Molecular and
Cellular Endocrinology. 2010
Pannier AK, Ariazi EA, Bellis AD, Bengali Z, Jordan VC, Shea LD. Bioluminescence imaging for assessment and
normalization in transfected cell arrays. Biotechnology and Bioengineering. 2007;98:486-497
Paoloni M, Gunderman J, Estelle L, Padilla M, Argyle D. Targeting the rna component of telomerase through rna
1967.
1968.
1969.
1970.
1971.
1972.
1973.
1974.
1975.
1976.
1977.
1978.
1979.
1980.
1981.
1982.
1983.
1984.
1985.
1986.
1987.
1988.
1989.
interference and the development of vector delivery systems. Veterinary and Comparative Oncology.
2005;3:33-34
Papo N, Seger D, Makovitzki A, Kalchenko V, Eshhar Z, Degani H, Shai Y. Inhibition of tumor growth and
elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host
defense-like lytic peptide. Cancer Res. 2006;66:5371-5378
Paragas N, Qiu A, Zhang Q, Samstein B, Deng SX, Schmidt-Ott KM, Viltard M, Yu W, Forster CS, Gong G, Liu Y,
Kulkarni R, Mori K, Kalandadze A, Ratner AJ, Devarajan P, Landry DW, D'Agati V, Lin CS, Barasch J. The ngal
reporter mouse detects the response of the kidney to injury in real time. Nature medicine. 2011;17:216-222
Paraskar AS, Soni S, Chin KT, Chaudhuri P, Muto KW, Berkowitz J, Handlogten MW, Alves NJ, Bilgicer B,
Dinulescu DM, Mashelkar RA, Sengupta S. Harnessing structure-activity relationship to engineer a cisplatin
nanoparticle for enhanced antitumor efficacy. Proc Natl Acad Sci U S A. 2010;107:12435-12440
Paraskevakou G, Allen C, Nakamura T, Zollman P, James C, Peng K, Schroeder M, Russell S, Galanis E. Epidermal
growth factor receptor (egfr)–retargeted measles virus strains effectively target egfr-or egfrviii expressing
gliomas. Molecular Therapy. 2007;15:677-686
Park CY, Chuck RS, Cano M, Yew M, Nguyen V, Parker J, Mori K, Gehlbach PL. Periocular triamcinolone enhances
intraocular gene expression after delivery by adenovirus. Invest Ophthalmol Vis Sci. 2008;49:399-406
Park HS, Cleary PP. Active and passive intranasal immunizations with streptococcal surface protein c5a peptidase
prevent infection of murine nasal mucosa-associated lymphoid tissue, a functional homologue of human tonsils.
Infection and Immunity. 2005;73:7878-7886
Park HS, Francis KP, Yu J, Cleary PP. Membranous cells in nasal-associated lymphoid tissue: A portal of entry for
the respiratory mucosal pathogen group a streptococcus. Journal of Immunology. 2003;171:2532-2537
Park JC, Il An G, Park SI, Oh J, Kim HJ, Su Ha Y, Wang EK, Min Kim K, Kim JY, Lee J, Welch MJ, Yoo J.
Luminescence imaging using radionuclides: A potential application in molecular imaging. Nuclear medicine
and biology. 2011;38:321-329
Park JH, Gu L, von Maltzahn G, Ruoslahti E, Bhatia SN, Sailor MJ. Biodegradable luminescent porous silicon
nanoparticles for in vivo applications. Nat Mater. 2009;8:331-336
Park JH, Kim KI, Lee YJ, Lee TS, Kim KM, Nahm SS, Park YS, Cheon GJ, Lim SM, Kang JH. Non-invasive
monitoring of hepatocellular carcinoma in transgenic mouse with bioluminescent imaging. Cancer letters.
2011;310:53-60
Park JS, Na K, Woo DG, Yang HN, Kim JM, Kim JH, Chung HM, Park KH. Non-viral gene delivery of DNA
polyplexed with nanoparticles transfected into human mesenchymal stem cells. Biomaterials. 2010;31:124-132
Park SI, Zhang J, Phillips KA, Araujo JC, Najjar AM, Volgin AY, Gelovani JG, Kim SJ, Wang Z, Gallick GE.
Targeting src family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude
mouse model. Cancer Res. 2008;68:3323-3333
Park SY, Bell GI. Noninvasive monitoring of changes in pancreatic beta-cell mass by bioluminescent imaging in
mip-luc transgenic mice. Horm Metab Res. 2009;41:1-4
Park SY, Wang X, Chen Z, Powers AC, Magnuson MA, Head WS, Piston DW, Bell GI. Optical imaging of pancreatic
beta cells in living mice expressing a mouse insulin i promoter-firefly luciferase transgene. Genesis.
2005;43:80-86
Parker AL, Waddington SN, Buckley SM, Custers J, Havenga MJ, van Rooijen N, Goudsmit J, McVey JH, Nicklin
SA, Baker AH. Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer. J Virol.
2009;83:479-483
Partridge J, Carlsen H, Enesa K, Chaudhury H, Zakkar M, Luong L, Kinderlerer A, Johns M, Blomhoff R, Mason JC,
Haskard DO, Evans PC. Laminar shear stress acts as a switch to regulate divergent functions of nf-kappab in
endothelial cells. Faseb J. 2007;21:3553-3561
Passineau MJ, Zourelias L, Machen L, Edwards PC, Benza RL. Ultrasound-assisted non-viral gene transfer to the
salivary glands. Gene Ther. 2010
Pastorino F, Di Paolo D, Piccardi F, Nico B, Ribatti D, Daga A, Baio G, Neumaier CE, Brignole C, Loi M,
Marimpietri D, Pagnan G, Cilli M, Lepekhin EA, Garde SV, Longhi R, Corti A, Allen TM, Wu JJ, Ponzoni M.
Enhanced antitumor efficacy of clinical-grade vasculature-targeted liposomal doxorubicin. Clin Cancer Res.
2008;14:7320-7329
Pastorino F, Loi M, Sapra P, Becherini P, Cilli M, Emionite L, Ribatti D, Greenberger LM, Horak ID, Ponzoni M.
Tumor regression and curability of preclinical neuroblastoma models by pegylated sn38 (ezn-2208), a novel
topoisomerase i inhibitor. Clinical cancer research : an official journal of the American Association for Cancer
Research. 2010;16:4809-4821
Patel M, Rosen D, Strauch B. Pulsed magnetic fields accelerate cutaneous wound healing in rats. Plastic and
Reconstructive Surgery. 2006;118:70
Patil CS, Liu M, Zhao W, Coatney DD, Li F, VanTubergen EA, D’Silva NJ, Kirkwood KL. Targeting mrna stability
arrests inflammatory bone loss. Mol Ther. 2008;16:1657-1664
Patra CR, Bhattacharya R, Wang E, Katarya A, Lau JS, Dutta S, Muders M, Wang S, Buhrow SA, Safgren SL,
Yaszemski MJ, Reid JM, Ames MM, Mukherjee P, Mukhopadhyay D. Targeted delivery of gemcitabine to
pancreatic adenocarcinoma using cetuximab as a targeting agent. Cancer Res. 2008;68:1970-1978
Patterson DM, Gao D, Trahan DN, Johnson BA, Ludwig A, Barbieri E, Chen Z, Diaz-Miron J, Vassilev L, Shohet
JM, Kim ES. Effect of mdm2 and vascular endothelial growth factor inhibition on tumor angiogenesis and
1990.
1991.
1992.
1993.
1994.
1995.
1996.
1997.
1998.
1999.
2000.
2001.
2002.
2003.
2004.
2005.
2006.
2007.
2008.
2009.
2010.
2011.
2012.
2013.
2014.
2015.
metastasis in neuroblastoma. Angiogenesis. 2011;14:255-266
Paulmurugan R, Gambhir SS. Monitoring protein-protein interactions using split synthetic renilla luciferase
protein-fragment-assisted complementation. Anal Chem. 2003;75:1584-1589
Paulmurugan R, Gambhir SS. Firefly luciferase enzyme fragment complementation for imaging in cells and living
animals. Anal Chem. 2005;77:1295-1302
Paulmurugan R, Gambhir SS. Novel fusion protein approach for efficient high-throughput screening of small
molecule-mediating protein-protein interactions in cells and living animals. Cancer Res. 2005;65:7413-7420
Paulmurugan R, Gambhir SS. An intramolecular folding sensor for imaging estrogen receptor-ligand interactions.
PNAS. 2006;103:15883-15888
Paulmurugan R, Gambhir SS. Combinatorial library screening for developing an improved split-firefly luciferase
fragment-assisted complementation system for studying protein-protein interactions. Anal Chem. 2007
Paulmurugan R, Massoud TF, Huang J, Gambhir SS. Molecular imaging of drug-modulated protein-protein
interactions in living subjects. Cancer Res. 2004;64:2113-2119
Paulmurugan R, Ray P, De A, Chan C, Gambhir S. Imaging protein-protein interactions in living subjects. TrAC
Trends in Analytical Chemistry. 2005;24:446-458
Paulmurugan R, Umezawa Y, Gambhir SS. Noninvasive imaging of protein–protein interactions in living
subjects by using reporter protein complementation and reconstitution strategies. Proceedings of the National
Academy of Sciences of the United States of America. 2002;99:15608-15613
Paur I, Austenaa LM, Blomhoff R. Extracts of dietary plants are efficient modulators of nuclear factor kappa b.
Food Chem Toxicol. 2008;46:1288-1297
Paur I, Balstad TR, Blomhoff R. Degree of roasting is the main determinant of the effects of coffee on nf-kappab
and epre. Free Radic Biol Med. 2010
Payne KA, Lee HH, Haleem AM, Martins C, Yuan Z, Qiao C, Xiao X, Chu CR. Single intra-articular injection of
adeno-associated virus results in stable and controllable in vivo transgene expression in normal rat knees.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2011;19:1058-1065
Pellegatti P, Raffaghello L, Bianchi G, Piccardi F, Pistoia V, Di Virgilio F. Increased level of extracellular atp at
tumor sites: In vivo imaging with plasma membrane luciferase. PLoS One. 2008;3
Peltola VT, Boyd KL, McAuley JL, Rehg JE, McCullers JA. Bacterial sinusitis and otitis media following
influenza virus infection in ferrets. Infection and Immunity. 2006;74:2562-2567
Peltola VT, Murti KG, McCullers JA. The influenza virus neuraminidase contributes to secondary bacterial
pneumonia. Journal of Infectious Diseases. 2005;192:249-257
Peltonen K, Colis L, Liu H, Jäämaa S, Moore HM, Enbäck J, Laakkonen P, Vaahtokari A, Jones RJ, af Hällström
TM, Laiho M. Identification of novel p53 pathway activating small-molecule compounds reveals unexpected
similarities with known therapeutic agents. PLoS One. 2010;5
Penack O, Henke E, Suh D, King CG, Smith OM, Na IK, Holland AM, Ghosh A, Lu SX, Jenq RR, Liu C, Murphy GF,
Lu TT, May C, Scheinberg DA, Gao DC, Mittal V, Heller G, Benezra R, van den Brink MR. Inhibition of
neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth. J Natl Cancer
Inst. 2010;102:894-908
Pendharkar AV, Chua JY, Andres RH, Wang N, Gaeta X, Wang H, De A, Choi R, Chen S, Rutt BK, Gambhir SS,
Guzman R. Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemia. Stroke.
2010;41:2064-2070
Peng H, Sohara Y, Moats R, Nelson M, Groshen S, Ye W, Reynolds C, DeClerck Y. The activity of zoledronic acid
on neuroblastoma bone metastasis involves inhibition of osteoclasts and tumor cell survival and proliferation.
Cancer Res. 2007;67:9346
Peng KW, Dogan A, Vrana J, Liu C, Ong HT, Kumar S, Dispenzieri A, Dietz AB, Russell SJ. Tumor-associated
macrophages infiltrate plasmacytomas and can serve as cell carriers for oncolytic measles virotherapy of
disseminated myeloma. American Journal of Hematology. 2009;84:401-407
Peng W, Chen J, Huang Y, Sawicki J. Tightly-regulated suicide gene expression kills psa-expressing prostate
tumor cells. Gene Therapy. 2005;12:1573-1580
Peng W, Ye Y, Rabinovich B, Liu C, Lou Y, Zhang M, Whittington M, Yang Y, Overwijk W, Lizée G. Transduction
of tumor-specific t cells with cxcr2 chemokine receptor improves migration to tumor and antitumor immune
responses. Clinical Cancer Research. 2010
Peng X, Tao K, Cheng T, Zhu J, Zhang X. Efficient inhibition of wear debris-induced inflammation by locally
delivered sirna. Biochem Biophys Res Commun. 2008;377:532-537
Peng XC, Zhang XL, Tao K, Cheng T, Zhu JF, Zeng BF. [locally administered lentivirus-mediated sirna inhibits
wear debris-induced inflammation]. Zhonghua Wai Ke Za Zhi. 2009;47:377-380
Pennisi A, Li X, Ling W, Khan S, Zangari M, Yaccoby S. The proteasome inhibitor, bortezomib suppresses primary
myeloma and stimulates bone formation in myelomatous and nonmyelomatous bones in vivo. American Journal
of Hematology. 2009;84:6-14
Penuelas I, Gambhir SS, Lammertsma AA. Imaging studies for evaluating gene therapy in translational research.
Drug Discovery Today: Technologies. 2005;2:335-343
Perales M, Diab A, Cohen A, Huggins D, Guevara-Patino J, Hubbard V, Engelhorn M, Kochman A, Eng J,
Mortazavi F. DNA immunization against tissue-restricted antigens enhances tumor immunity after allogeneic
hemopoietic stem cell transplantation. The Journal of Immunology. 2006;177:4159
2016.
Perez-Martinez A, Iyengar R, Gan K, Chotsampancharoen T, Rooney B, Holladay M, Ramírez M, Leung W. Blood
dendritic cells suppress nk cell function and increase the risk of leukemia relapse after hematopoietic cell
transplantation. Biology of Blood and Marrow Transplantation. 2010
2017.
Perin L, Sedrakyan S, Giuliani S, Da Sacco S, Carraro G, Shiri L, Lemley K, Rosol M, Wu S, Atala A, Warburton D,
De Filippo R. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute
tubular necrosis. PLoS ONE. 2010
2018.
Persaud-Sawin D, VanDongen A, Boustany R. Motifs within the cln3 protein: Modulation of cell growth rates and
apoptosis. Human Molecular Genetics. 2002;11:2129
2019.
Peterson JR, Infanger DW, Braga VA, Zhang Y, Sharma RV, Engelhardt JF, Davisson RL. Longitudinal noninvasive monitoring of transcription factor activation in cardiovascular regulatory nuclei using
bioluminescence imaging. Physiol Genomics. 2008
2020.
Pettigrew LC, Kindy MS, Scheff S, Springer JE, Kryscio RJ, Li Y, Grass DS. Focal cerebral ischemia in the
tnfalpha-transgenic rat. J Neuroinflammation. 2008;5:47
2021.
Pettway GJ, McCauley LK. Ossicle and vossicle implant model systems. Methods Mol Biol. 2008;455:101-110
2022.
Pettway GJ, Meganck JA, Koh AJ, Keller ET, Goldstein SA, McCauley LK. Parathyroid hormone mediates bone
growth through the regulation of osteoblast proliferation and differentiation. Bone. 2008;42:806-818
2023.
Pham W, Xie J, Gore JC. Tracking the migration of dendritic cells by in vivo optical imaging. Neoplasia.
2007;9:1130-1137
2024.
Phelps EA, Landazuri N, Thule PM, Taylor WR, Garcia AJ. Regenerative medicine special feature: Bioartificial
matrices for therapeutic vascularization. Proc Natl Acad Sci U S A. 2010;107:3323-3328
2025.
Phillips B, Nylander K, Harnaha J, Machen J, Lakomy R, Styche A, Gillis K, Brown L, Lafreniere D, Gallo M, Knox
J, Hogeland K, Trucco M, Giannoukakis N. A microsphere-based vaccine prevents and reverses new-onset
autoimmune diabetes. Diabetes. 2008;57:1544-1555
2026.
Phillips P, Dudeja V, McCarroll J, Borja-Cacho D, Dawra R, Grizzle W, Vickers S, Saluja A. Triptolide induces
pancreatic cancer cell death via inhibition of heat shock protein 70. Cancer Res. 2007;67:9407
2027.
Pic E, Bezdetnaya L, Guillemin F, Marchal F. Quantification techniques and biodistribution of semiconductor
quantum dots. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry.
2009;9:295-303
2028.
Pichler A, Prior JL, Luker GD, Piwnica-Worms D. Generation of a highly inducible gal4→fluc universal reporter
mouse for in vivo bioluminescence imaging. Proceedings of the National Academy of Sciences of the United
States of America. 2008;105:15932-15937
2029.
Pichler A, Prior JL, Piwnica-Worms D. Imaging reversal of multidrug resistance in living mice with
bioluminescence: Mdr1 p-glycoprotein transports coelenterazine. Proceedings of the National Academy of
Sciences of the United States of America. 2004;101:1702-1707
2030.
Pichler A, Zelcer N, Prior JL, Kuil AJ, Piwnica-Worms D. In vivo rna interference-mediated ablation of mdr1 pglycoprotein. Clin Cancer Res. 2005;11:4487-4494
2031.
Pietrella D, Rachini A, Pines M, Pandey N, Mosci P, Bistoni F, d'Enfert C, Vecchiarelli A. Th17 cells and il-17 in
protective immunity to vaginal candidiasis. PloS one. 2011;6:e22770
2032.
Pietrella D, Rachini A, Torosantucci A, Chiani P, Brown AJ, Bistoni F, Costantino P, Mosci P, d'Enfert C,
Rappuoli R, Cassone A, Vecchiarelli A. A beta-glucan-conjugate vaccine and anti-beta-glucan antibodies are
effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique. Vaccine.
2010;28:1717-1725
2033.
Piliponsky AM, Chen CC, Grimbaldeston MA, Burns-Guydish SM, Hardy J, Kalesnikoff J, Contag CH, Tsai M,
Galli SJ. Mast cell-derived tnf can exacerbate mortality during severe bacterial infections in c57bl/6-kitw-sh/wsh mice. Am J Pathol. 2010;176:926-938
2034.
Pinsky M, Song W, Dong Z, Warner K, Zeitlin B, Karl E, Hall D, Nör J. Activation of icaspase-9 in neovessels
inhibits oral tumor progression. Journal of Dental Research. 2006;85:436-441
2035.
Piwnica Worms D, Schuster D, Garbow J. Molecular imaging of host–pathogen interactions in intact small
animals. Cellular Microbiology. 2004;6:319-331
2036.
Piwnica-Worms D, Luker K. Imaging protein-protein interactions in whole cells and living animals. Molecular
Imaging. 2005;49:35-41
2037.
Planel S, Salomon A, Jalinot P, Feige JJ, Cherradi N. A novel concept in antiangiogenic and antitumoral therapy:
Multitarget destabilization of short-lived mrnas by the zinc finger protein zfp36l1. Oncogene. 2010
;29:5989-6003
2038.
Plastaras JP, Kim SH, Liu YY, Dicker DT, Dorsey JF, McDonough J, Cerniglia G, Rajendran RR, Gupta A, Rustgi
AK, Diehl JA, Smith CD, Flaherty KT, El-Deiry WS. Cell cycle dependent and schedule-dependent antitumor
effects of sorafenib combined with radiation. Cancer Res. 2007;67:9443-9454
2039.
Ploemen IH, Prudencio M, Douradinha BG, Ramesar J, Fonager J, van Gemert GJ, Luty AJ, Hermsen CC, Sauerwein
RW, Baptista FG, Mota MM, Waters AP, Que I, Lowik CW, Khan SM, Janse CJ, Franke-Fayard BM. Visualisation
and quantitative analysis of the rodent malaria liver stage by real time imaging. PLoS One. 2009;4:e7881
2040.
Podetz-Pedersen K, Bell J, Steele T, Frandsen J, Shier T, McIvor R, Hackett P. Quantitative evaluation of long term
gene expression in vivo after delivery of polyethylenimine-conjugated sleeping beauty transposon DNA.
Molecular Therapy. 2006;13:S70
2041.
Podetz-Pedersen KM, Bell JB, Steele TW, Wilber A, Shier WT, Belur LR, McIvor RS, Hackett PB. Gene expression
2042.
2043.
2044.
2045.
2046.
2047.
2048.
2049.
2050.
2051.
2052.
2053.
2054.
2055.
2056.
2057.
2058.
2059.
2060.
2061.
2062.
2063.
2064.
in lung and liver after intravenous infusion of polyethylenimine complexes of sleeping beauty transposons.
Hum Gene Ther. 2010;21:210-220
Podsypanina K, Du YC, Jechlinger M, Beverly LJ, Hambardzumyan D, Varmus H. Seeding and propagation of
untransformed mouse mammary cells in the lung. Science. 2008;321:1841-1844
Polevoda B, Cardillo TS, Doyle TC, Bedi GS, Sherman F. Nat3p and mdm20p are required for function of yeast
natb n(alpha)-terminal acetyltransferase and of actin and tropomyosin. Journal of Biological Chemistry.
2003;278:30686-30697
Polyak B, Fishbein I, Chorny M, Alferiev I, Williams D, Yellen B, Friedman G, Levy RJ. High field gradient
targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents. Proceedings of the
National Academy of Sciences of the United States of America. 2008;105:698-703
Pomper MG, Hammond H, Yu X, Ye Z, Foss CA, Lin DD, Fox JJ, Cheng L. Serial imaging of human embryonic
stem-cell engraftment and teratoma formation in live mouse models. Cell research. 2009;19:370-379
Poon Z, Lee JB, Morton SW, Hammond PT. Controlling in vivo stability and biodistribution in electrostatically
assembled nanoparticles for systemic delivery. Nano letters. 2011;11:2096-2103
Popescu M, Toms S. In vivo optical imaging using quantum dots for the management of brain tumors. Expert
Review of Molecular Diagnostics. 2006;6:879-890
Porkka K, Koskenvesa P, Lundan T, Rimpilainen J, Mustjoki S, Smykla R, Wild R, Luo R, Arnan M, Brethon B,
Eccersley L, Hjorth-Hansen H, Hoglund M, Klamova H, Knutsen H, Parikh S, Raffoux E, Gruber F, Brito-Babapulle
F, Dombret H, Duarte RF, Elonen E, Paquette R, Zwaan CM, Lee FY. Dasatinib crosses the blood-brain barrier and
is an efficient therapy for central nervous system philadelphia chromosome-positive leukemia. Blood.
2008;112:1005-1012
Power AT, Wang J, Falls TJ, Paterson JM, Parato KA, Lichty BD, Stojdl DF, Forsyth PA, Atkins H, Bell JC. Carrier
cell-based delivery of an oncolytic virus circumvents antiviral immunity. Mol Ther. 2007;15:123-130
Powers JG, Sit TL, Qu F, Morris TJ, Kim KH, Lommel SA. A versatile assay for the identification of rna silencing
suppressors based on complementation of viral movement. Mol Plant Microbe Interact. 2008;21:879-890
Pozzi-Mucelli S, Boschi F, Calderan L, Sbarbati A, Osculati F. Quantum dots: Proteomics characterization of the
impact on biological systems. Journal of Physics. 2009;170:012021
Prajapati SI, Martinez CO, Abraham J, McCleish AT, Michalek JE, McManus LM, Rubin BP, Shireman PK, Keller
C. Crimson carrier, a long-acting contrast agent for in vivo near-infrared imaging of injured and diseased muscle.
Muscle Nerve. 2010
Prajapati SI, Martinez CO, Bahadur AN, Wu IQ, Zheng W, Lechleiter JD, McManus LM, Chisholm GB, Michalek JE,
Shireman PK, Keller C. Near-infrared imaging of injured tissue in living subjects using ir-820. Mol Imaging.
2009;8:45-54
Prasad G, Sottero T, Yang X, Mueller S, James CD, Weiss WA, Polley MY, Ozawa T, Berger MS, Aftab DT, Prados
MD, Haas-Kogan DA. Inhibition of pi3k/mtor pathways in glioblastoma and implications for combination
therapy with temozolomide. Neuro-oncology. 2011;13:384-392
Prasad K-MR, Xu Y, Yang Z, Berr SS, French BA. High-efficiency, cardiac-specific gene expression from a single
intravenous injection using an aav-2 vector pseudotyped with aav-1 and-6 capsids in combination with the
cardiac troponin-t promoter. Circulation. 2006;114:121
Prasad K-MR, Xu Y, Yang Z, Berr SS, French BA. Pseudotyped aav vectors in combination with the cardiac
troponin-t promoter dramatically accelerate the onset of cardiac-specific gene expression after direct injection
into adult murine myocardium. Circulation. 2006;114:122
Prasad K-MR, Xu Y, Yang Z, Berr SS, French BA. Cardiac-specific gene expression after systemic administration
to adult mice using pseudotyped aav vectors and the cardiac troponin-t promoter: Comparison with direct
injection. Circulation. 2007;116:65
Prasad KM, Xu Y, Yang Z, Toufektsian MC, Berr SS, French BA. Topoisomerase inhibition accelerates gene
expression after adeno-associated virus-mediated gene transfer to the mammalian heart. Mol Ther.
2007;15:764-771
Pratap J, Imbalzano KM, Underwood JM, Cohet N, Gokul K, Akech J, van Wijnen AJ, Stein JL, Imbalzano AN,
Nickerson JA, Lian JB, Stein GS. Ectopic runx2 expression in mammary epithelial cells disrupts formation of
normal acini structure: Implications for breast cancer progression. Cancer Res. 2009;69:6807-6814
Prather WR, Toren A, Meiron M, Ofir R, Tschope C, Horwitz EM. The role of placental-derived adherent stromal
cell (plx-pad) in the treatment of critical limb ischemia. Cytotherapy. 2009;11:427-434
Prescott D, Gordon J. Total skin electron beam irradiation for generalized cutaneous lymphoma. Veterinary and
Comparative Oncology. 2005;3:32
Pribaz JR, Bernthal NM, Billi F, Cho JS, Ramos RI, Guo Y, Cheung AL, Francis KP, Miller LS. Mouse model of
chronic post-arthroplasty infection: Noninvasive in vivo bioluminescence imaging to monitor bacterial burden
for long-term study. Journal of orthopaedic research : official publication of the Orthopaedic Research
Society. 2011
Priddle H, Grabowska A, Morris T, Clarke PA, McKenzie AJ, Sottile V, Denning C, Young L, Watson S.
Bioluminescence imaging of human embryonic stem cells transplanted in vivo in murine and chick models.
Cloning Stem Cells. 2009;11:259-267
Prins R, Bruhn KW, Craft N, Lin JW, Kim CH, Odesa SK, Miller JF, Liau LM. Central nervous system tumor
immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and
2065.
2066.
2067.
2068.
2069.
2070.
2071.
2072.
2073.
2074.
2075.
2076.
2077.
2078.
2079.
2080.
2081.
2082.
2083.
2084.
2085.
2086.
2087.
2088.
2089.
2090.
2091.
real-time imaging of intracranial tumor burden. Neurosurgery. 2006;58:169-178
Prins RM, Craft N, Bruhn KW, Khan-Farooqi H, Koya RC, Stripecke R, Miller JF, Liau LM. The tlr-7 agonist,
imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific t cell priming: Relation to
central nervous system antitumor immunity. J Immunol. 2006;176:157-164
Prins RM, Shu CJ, Radu CG, Vo DD, Khan-Farooqi H, Soto H, Yang MY, Lin MS, Shelly S, Witte ON, Ribas A, Liau
LM. Anti-tumor activity and trafficking of self, tumor-specific t cells against tumors located in the braina,b.
Cancer Immunology, Immunotherapy. 2008;57:1279-1289
Prins RM, Vo DD, Khan-Farooqi H, Yang MY, Soto H, Economou JS, Liau LM, Ribas A. Nk and cd4 cells
collaborate to protect against melanoma tumor formation in the brain. J Immunol. 2006;177:8448-8455
Proulx ST, Luciani P, Derzsi S, Rinderknecht M, Mumprecht V, Leroux JC, Detmar M. Quantitative imaging of
lymphatic function with liposomal indocyanine green. Cancer Res. 2010;70:7053-7062
Prout DL, Silverman RW, Chatziioannou A. Detector concept for opet—a combined pet and optical imaging
system. IEEE Trans Nucl Sci. 2004;51:752-756
Prout DL, Silverman RW, Chatziioannou A. Readout of the optical pet (opet) detector. IEEE Trans Nucl Sci.
2005;52:28-32
Pruett SB, Fan R. Ethanol inhibits lps-induced signaling and modulates cytokine production in peritoneal
macrophages in vivo in a model for binge drinking. BMC Immunol. 2009;10:49
Psallidas I, Karabela SP, Moschos C, Sherrill TP, Kollintza A, Magkouta S, Theodoropoulou P, Roussos C,
Blackwell TS, Kalomenidis I, Stathopoulos GT. Specific effects of bortezomib against experimental malignant
pleural effusion: A preclinical study. Mol Cancer. 2010;9:56
Pujal J, Huch M, Jose A, Abasolo I, Rodolosse A, Duch A, Sanchez-Palazon L, Smith F, McLean W, Fillat C.
Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in
vitro and in vivo. The FASEB Journal. 2009;23:1366
Pulukuri SM, Estes N, Patel J, Rao JS. Demethylation-linked activation of urokinase plasminogen activator is
involved in progression of prostate cancer. Cancer Res. 2007;67:930-939
Pulukuri SM, Rao JS. Small interfering rna directed reversal of urokinase plasminogen activator demethylation
inhibits prostate tumor growth and metastasis. Cancer Res. 2007;67:6637-6646
Pulukuri SM, Rao JS. Matrix metalloproteinase-1 promotes prostate tumor growth and metastasis. Int J Oncol.
2008;32:757-765
Pulukuri SMK, Gorantla B, Knost JA, Rao JS. Frequent loss of cystatin e/m expression implicated in the
progression of prostate cancer. Oncogene. 2009;28:2829-2838
Pulverer JE, Rand U, Lienenklaus S, Kugel D, Zietara N, Kochs G, Naumann R, Weiss S, Staeheli P, Hauser H,
Koster M. Temporal and spatial resolution of type i and iii interferon responses in vivo. J Virol.
2010;84:8626-8638
Qayum N, Muschel RJ, Im JH, Balathasan L, Koch CJ, Patel S, McKenna WG, Bernhard EJ. Tumor vascular changes
mediated by inhibition of oncogenic signaling. Cancer Res. 2009;69:6347-6354
Qian D, Wei Y, Wang X, Kato Y, Cheng L, Pili R. Antitumor activity of the histone deacetylase inhibitor ms 275
in prostate cancer models. Prostate. 2007;67:1182-1193
Qian DZ, Ren M, Wei Y, Wang X, van de Geijn F, Rasmussen C, Nakanishi O, Sacchi N, Pili R. In vivo imaging of
retinoic acid receptor beta2 transcriptional activation by the histone deacetylase inhibitor ms-275 in retinoidresistant prostate cancer cells. Prostate. 2005;64:20-28
Qin C, Zhu S, Tian J. New optical molecular imaging systems. Current Pharmaceutical Biotechnology.
2010;11:620-627
Qin L, Greenland JR, Moriya C, Cayabyab MJ, Letvin NL. Effects of type i interferons on the adjuvant properties
of plasmid granulocyte-macrophage colony-stimulating factor in vivo▿. J Virol. 2007;81:10606-10613
Qin S, Seo J, Zhang H, Qi J, Curry F, Ferrara K. An imaging-driven model for liposomal stability and circulation.
Molecular Pharmaceutics. 2009;7:12-21
Qiu X, Zeng L, Urban J, Nikolskaya A, Audet S. Evaluation of polymer-DNA nanoparticles for gene transfer to
cardiac muscles. Molecular Therapy. 2010;18:S155
Qiu Z, Harms JS, Zhu J, Splitter GA. Bovine herpesvirus tegument protein vp22 enhances thymidine kinase/
ganciclovir suicide gene therapy for neuroblastomas compared to herpes simplex virus vp22. J Virol.
2004;78:4224-4233
Quaak S, den Berg J, Oosterhuis K, Beijnen J, Haanen J, Nuijen B. DNA tattoo vaccination: Effect on plasmid
purity and transfection efficiency of different topoisoforms. Journal of Controlled Release. 2009;139:153-159
Quaak SGL, Haanen J, Beijnen JH, Nuijen B. Naked plasmid DNA formulation: Effect of different disaccharides on
stability after lyophilisation. AAPS PharmSciTech. 2010;11:344-350
Quinn BA, Xiao F, Bickel L, Martin L, Hua X, Klein-Szanto A, Connolly DC. Development of a syngeneic mouse
model of epithelial ovarian cancer. J Ovarian Res. 2010;3:24
Quintarelli C, Juan V, Savoldo B, Giordano G, Foster A, Pule M, Heslop HM, Rooney C, Brenner MK, Dotti G.
Transgenic expression of inducible caspase9 suicide gene for in vivo elimination of antigen specific cytotoxic t
cells (ctls) engineered to produce cytokines. Blood. 2006;108:45A
Quintarelli C, Vera JF, Savoldo B, Giordano Attianese GMP, Pule M, Foster AE, Heslop HE, Rooney CM, Brenner
MK, Dotti G. Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific
cytotoxic t lymphocytes. Blood. 2007;110:2793-2802
2092.
2093.
2094.
2095.
2096.
2097.
2098.
2099.
2100.
2101.
2102.
2103.
2104.
2105.
2106.
2107.
2108.
2109.
2110.
2111.
2112.
2113.
2114.
2115.
Rabinovich BA, Ye Y, Etto T, Chen JQ, Levitsky HI, Overwijk WW, Cooper LJN, Gelovani J, Hwu P. Visualizing
fewer than 10 mouse t cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer.
Proceedings of the National Academy of Sciences of the United States of America. 2008;105:14342-14346
Rabinovich PM, Komarovskaya ME, Wrzesinski SH, Alderman JL, Budak-Alpdogan T, Karpikov A, Guo H, Flavell
RA, Cheung NK, Weissman SM, Bahceci E. Chimeric receptor mrna transfection as a tool to generate
antineoplastic lymphocytes. Human Gene Therapy. 2009;20:51-61
Radhakrishnan GK, Yu Q, Harms JS, Splitter GA. Brucella tir domain-containing protein mimics properties of the
toll-like receptor adaptor protein tirap*s . Journal of Biological Chemistry. 2009;284:9892-9898
Radin J, Orihuela C, Murti G, Guglielmo C, Murray P, Tuomanen E. {beta}-arrestin 1 participates in plateletactivating factor receptor-mediated endocytosis of streptococcus pneumoniae. Infection and Immunity.
2005;73:7827
Radin JN, Orihuela CJ, Murti G, Guglielmo C, Murray PJ, Tuomanen EI. Β-arrestin 1 participates in plateletactivating factor receptor-mediated endocytosis of streptococcus pneumoniae†. Infection and Immunity.
2005;73:7827-7835
Radu CG, Cheng D, Nijagal A, Riedinger M, McLaughlin J, Yang LV, Johnson J, Witte ON. Normal immune
development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the t-cell death-associated
gene 8 receptor. Molecular and Cellular Biology. 2006;26:668-677
Ragel BT, Elam IL, Gillespie DL, Flynn JR, Kelly DA, Mabey D, Feng H, Couldwell WT, Jensen RL. A novel model
of intracranial meningioma in mice using luciferase-expressing meningioma cells. Laboratory investigation. J
Neurosurg. 2008;108:304-310
Rai D, Kim SW, McKeller MR, Dahia PL, Aguiar RC. Targeting of smad5 links microrna-155 to the tgf-beta
pathway and lymphomagenesis. Proc Natl Acad Sci U S A. 2010;107:3111-3116
Raikwar SP, Zavazava N. Spontaneous in vivo differentiation of embryonic stem cell-derived pancreatic
endoderm-like cells corrects hyperglycemia in diabetic mice. Transplantation. 2011;91:11-20
Raj VS, Fournier G, Rakus K, Ronsmans M, Ouyang P, Michel B, Delforges C, Costes B, Farnir F, Leroy B, Wattiez
R, Melard C, Mast J, Lieffrig F, Vanderplasschen A. Skin mucus of cyprinus carpio inhibits cyprinid herpesvirus
3 binding to epidermal cells. Veterinary research. 2011;42:92
Rajashekara G, Glover DA, Banai M, O'Callaghan D, Splitter GA. Attenuated bioluminescent brucella melitensis
mutants gr019 (virb4), gr024 (gale), and gr026 (bmei1090-bmei1091) confer protection in mice. Infection and
Immunity. 2006;74:2925-2936
Rajashekara G, Glover DA, Krepps M, Splitter GA. Temporal analysis of pathogenic events in virulent and
avirulent brucella melitensis infections. Cellular Microbiology. 2005;7:1459-1473
Rajashekara G, Krepps M, Eskra L, Mathison A, Montgomery A, Ishii Y, Splitter G. Unraveling brucella genomics
and pathogenesis in immunocompromised irf-1-/- mice. American Journal of Reproductive Immunology.
2005;54:358-368
Rajendran S, Collins S, van Pijkeren JP, O'Hanlon D, O'Sullivan GC, Tangney M. Targeting of breast metastases
using a viral gene vector with tumour-selective transcription. Anticancer research. 2011;31:1627-1635
Rajendran S, O'Hanlon D, Morrissey D, O'Donovan T, O'Sullivan GC, Tangney M. Preclinical evaluation of gene
delivery methods for the treatment of loco-regional disease in breast cancer. Experimental biology and medicine.
2011;236:423-434
Raki M, Hakkarainen T, Bauerschmitz GJ, Sarkioja M, Desmond RA, Kanerva A, Hemminki A. Utility of tk/gcv in
the context of highly effective oncolysis mediated by a serotype 3 receptor targeted oncolytic adenovirus. Gene
Ther. 2007;14:1380-1388
Ramachandran V, Arumugam T, Hwang R, Greenson J, Simeone D, Logsdon C. Adrenomedullin is expressed in
pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin
receptor, admr. Cancer Res. 2007;67:2666
Ramachandran V, Arumugam T, Langley R, Hwang RF, Vivas-Mejia P, Sood AK, Lopez-Berestein G, Logsdon CD.
The admr receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor
microenvironment. PLoS One. 2009;4
Ramachandran V, Arumugam T, Wang H, Logsdon CD. Anterior gradient 2 is expressed and secreted during the
development of pancreatic cancer and promotes cancer cell survival. Cancer Res. 2008;68:7811-7818
Ramakrishna E, Woller N, Mundt B, Knocke S, Gurlevik E, Saborowski M, Malek N, Manns MP, Wirth T, Kuhnel F,
Kubicka S. Antitumoral immune response by recruitment and expansion of dendritic cells in tumors infected
with telomerase-dependent oncolytic viruses. Cancer Res. 2009;69:1448-1458
Rambow-Larsen AA, Rajashekara G, Petersen E, Splitter G. Putative quorum-sensing regulator blxr of brucella
melitensis regulates virulence factors including the type iv secretion system and flagella. J Bacteriol.
2008;190:3274-3282
Ramesh N, Ge Y, Ennist DL, Zhu M, Mina M, Ganesh S, Reddy PS, Yu D-C. Cg0070, a conditionally replicating
granulocyte macrophage colony-stimulating factor-armed oncolytic adenovirus for the treatment of bladder
cancer. Clin Cancer Res. 2006;12:305-313
Ramesh N, Ge Y, Liu J, Farson D, Van Roey M, Rojas V, Working P, Yu D. Development of an orthotopic bladder
tumor model in mice and demonstration of antitumor efficacy with an oncolytic adenovirus cg8840 for the
treatment of bladder cancer. Proceedings of the American Association for Cancer Research. 2004;2004:1184
Ramirez-Montagut T, Chow A, Hirschhorn-Cymerman D, Terwey TH, Kochman AA, Lu S, Miles RC, Sakaguchi S,
2116.
2117.
2118.
2119.
2120.
2121.
2122.
2123.
2124.
2125.
2126.
2127.
2128.
2129.
2130.
2131.
2132.
2133.
2134.
2135.
2136.
2137.
Houghton AN, van den Brink MR. Glucocorticoid-induced tnf receptor family related gene activation overcomes
tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity. J Immunol.
2006;176:6434-6442
Ramirez-Montagut T, Chow A, Kochman AA, Smith OM, Suh D, Sindhi H, Lu S, Borsotti C, Grubin J, Patel N,
Terwey TH, Kim TD, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR. Ifn-gamma and fas ligand are
required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host
disease. J Immunol. 2007;179:1669-1680
Ramos OH, Kauskot A, Cominetti MR, Bechyne I, Salla Pontes CL, Chareyre F, Manent J, Vassy R, Giovannini M,
Legrand C, Selistre-de-Araujo HS, Crepin M, Bonnefoy A. A novel alpha(v)beta (3)-blocking disintegrin
containing the rgd motive, disba-01, inhibits bfgf-induced angiogenesis and melanoma metastasis. Clin Exp
Metastasis. 2007
Ramphal R, Balloy V, Jyot J, Verma A, Si-Tahar M, Chignard M. Control of pseudomonas aeruginosa in the lung
requires the recognition of either lipopolysaccharide or flagellin1. Journal of Immunology. 2008;181:586-592
Ramseier CA, Abramson ZR, Jin Q, Giannobile WV. Gene therapeutics for periodontal regenerative medicine.
Dental Clinics of North America. 2006;50:245-ix
Ran C, Moore A. Spectral unmixing imaging of wavelength-responsive fluorescent probes: An application for the
real-time report of amyloid beta species in alzheimer's disease. Molecular imaging and biology : MIB : the
official publication of the Academy of Molecular Imaging. 2011
Ran C, Zhang Z, Hooker J, Moore A. In vivo photoactivation without "light": Use of cherenkov radiation to
overcome the penetration limit of light. Molecular imaging and biology : MIB : the official publication of the
Academy of Molecular Imaging. 2011
Randall LM, Amante FH, McSweeney KA, Zhou Y, Stanley AC, Haque A, Jones MK, Hill GR, Boyle GM, Engwerda
CR. Common strategies to prevent and modulate experimental cerebral malaria in mouse strains with different
susceptibilities. Infect Immun. 2008;76:3312-3320
Rando G, Biserni A, Ciana P, Maggi A. Profiling of drug action using reporter mice and molecular imaging.
Mouse models for drug discovery. 2010:79-92.
Ranjan AP, Zeglam K, Mukerjee A, Thamake S, Vishwanatha JK. A sustained release formulation of chitosan
modified plcl:Poloxamer blend nanoparticles loaded with optical agent for animal imaging. Nanotechnology.
2011;22:295104
Ranki T, Kanerva A, Ristimaki A, Hakkarainen T, Sarkioja M, Kangasniemi L, Raki M, Laakkonen P, Goodison S,
Hemminki A. A heparan sulfate-targeted conditionally replicative adenovirus, ad5.Pk7-delta24, for the treatment
of advanced breast cancer. Gene Ther. 2007;14:58-67
Ranki T, Särkioja M, Hakkarainen T, Smitten K, Kanerva A, Hemminki A. Systemic efficacy of oncolytic
adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer. International
Journal of Cancer. 2007;121:165-174
Ransohoff KJ, Wu JC. Advances in cardiovascular molecular imaging for tracking stem cell therapy. Thrombosis
and haemostasis. 2010;104:13-22
Rapisarda A, Hollingshead M, Uranchimeg B, Bonomi CA, Borgel SD, Carter JP, Gehrs B, Raffeld M, Kinders RJ,
Parchment R, Anver MR, Shoemaker RH, Melillo G. Increased anti-tumor activity of bevacizumab in combination
with hif-1 inhibition. Mol Cancer Ther. 2009;8:1867-1877
Rapisarda A, Uranchimeg B, Hollingshead M, Zalek J, Bonomi C, Borgel S, Carter J, Shoemaker R, Melillo G.
Inhibition of hif-1 dependent luciferase and vegf expression in u251 xenograft by topotecan. Proceedings of the
American Association for Cancer Research. 2004;2004:130
Raska M, Moldoveanu Z, Novak J, Hel Z, Bozja J, Compans RW, Yang C, Mestecky J. Delivery of DNA hiv-1
vaccine to the liver induces high and long-lasting humoral immune responses. Vaccine. 2008;26:1541-1551
Rastegar F, Gao J-L, Shenaq D, Luo Q, Shi Q, Kim SH, Jiang W, Wagner ER, Huang E, Gao Y, Shen J, Yang K, He BC, Chen L, Zuo GW, Luo J, Luo X, Bi Y, Liu X, Li M, Hu N, Wang L, Luther G, Luu HH, Haydon RC, He T-C.
Lysophosphatidic acid acyltransferase β (lpaatβ) promotes the tumor growth of human osteosarcoma. PLoS ONE.
2010
Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H,
Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D,
Freeman RS, Semenza GL, Gazaryan I. Small molecule activation of adaptive gene expression: Tilorone or its
analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and
spinal cord injury. Annals of the New York Academy of Sciences. 2008;1147:383-394
Rauch D, Gross S, Harding J, Bokhari S, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L. T-cell activation
promotes tumorigenesis in inflammation-associated cancer. Retrovirology. 2009;6:116
Rauch D, Gross S, Harding J, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L. Imaging spontaneous
tumorigenesis: Inflammation precedes development of peripheral nk tumors. Blood. 2008
Ray P, De A, Min JJ, Tsien RY, Gambhir SS. Imaging tri-fusion multimodality reporter gene expression in living
subjects. Cancer Res. 2004;64:1323-1330
Ray P, De A, Patel M, Gambhir SS. Monitoring caspase-3 activation with a multimodality imaging sensor in
living subjects. Clin Cancer Res. 2008;14:5801-5809
Ray P, Gambhir SS. Noninvasive imaging of molecular events with bioluminescent reporter genes in living
subjects. Reporter genes. 2007:131-144.
2138.
2139.
2140.
2141.
2142.
2143.
2144.
2145.
2146.
2147.
2148.
2149.
2150.
2151.
2152.
2153.
2154.
2155.
2156.
2157.
2158.
2159.
2160.
2161.
2162.
2163.
Ray P, Pimenta H, Paulmurugan R, Berger F, Phelps ME, Iyer M, Gambhir SS. Noninvasive quantitative imaging
of protein–protein interactions in living subjects. Proceedings of the National Academy of Sciences of the
United States of America. 2002;99:3105-3110
Ray P, Tsien R, Gambhir SS. Construction and validation of improved triple fusion reporter gene vectors for
molecular imaging of living subjects. Cancer Res. 2007;67:3085-3093
Ray P, Wu AM, Gambhir SS. Optical bioluminescence and positron emission tomography imaging of a novel
fusion reporter gene in tumor xenografts of living mice. Cancer Res. 2003;63:1160-1165
Ray S, Paulmurugan R, Patel MR, Ahn BC, Wu L, Carey M, Gambhir SS. Noninvasive imaging of therapeutic gene
expression using a bidirectional transcriptional amplification strategy. Mol Ther. 2008;16:1848-1856
Razavi R, Harrison LE. Thermal sensitization using induced oxidative stress decreases tumor growth in an in
vivo model of hyperthermic intraperitoneal perfusion. Ann Surg Oncol. 2010;17:304-311
Razmara M, Hilliard B, Ziarani AK, Murali R, Yellayi S, Ghazanfar M, Chen YH, Tykocinski ML. Fn14-trail, a
chimeric intercellular signal exchanger, attenuates experimental autoimmune encephalomyelitis. American
Journal of Pathology. 2009;174:460-474
Real PJ, Tosello V, Palomero T, Castillo M, Hernando E, de Stanchina E, Sulis ML, Barnes K, Sawai C, Homminga
I, Meijerink J, Aifantis I, Basso G, Cordon-Cardo C, Ai W, Ferrando A. Gamma-secretase inhibitors reverse
glucocorticoid resistance in t-all. Nature Medicine. 2009;15:50-58
Redding KM, Chen BL, Singh A, Re RN, Navar LG, Seth DM, Sigmund CD, Tang WW, Cook JL. Transgenic mice
expressing an intracellular fluorescent fusion of angiotensin ii demonstrate renal thrombotic microangiopathy
and elevated blood pressure. Am J Physiol Heart Circ Physiol. 2010;298:H1807-1818
Redjal N, Chan J, Segal R, Kung A. Cxcr4 inhibition synergizes with cytotoxic chemotherapy in gliomas.
Clinical Cancer Research. 2006;12:6765
Rehemtulla A, Hall DE, Stegman LD, Prasad U, Chen G, Bhojani MS, Chenevert TL, Ross BD. Molecular imaging
of gene expression and efficacy following adenoviral-mediated brain tumor gene therapy. Mol Imaging.
2002;1:43-55
Rehemtulla A, Stegman LD, Cardozo SJ, Gupta S, Hall DE, Contag CH, Ross BD. Rapid and quantitative
assessment of cancer treatment response using in vivo bioluminescence imaging. Neoplasia. 2000;2:491-495
Rehemtulla A, Taneja N, Ross BD. Bioluminescence detection of cells having stabilized p53 in response to a
genotoxic event. Mol Imaging. 2004;3:63-68
Reichardt W, Durr C, von Elverfeldt D, Juttner E, Gerlach UV, Yamada M, Smith B, Negrin RS, Zeiser R. Impact of
mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticlelabeled dendritic cells following allogeneic hematopoietic cell transplantation. J Immunol. 2008;181:4770-4779
Reka AK, Kurapati H, Narala VR, Bommer G, Chen J, Standiford TJ, Keshamouni VG. Peroxisome proliferatoractivated receptor-gamma activation inhibits tumor metastasis by antagonizing smad3-mediated epithelialmesenchymal transition. Mol Cancer Ther. 2010;9:3221-3232
Remiszewski SW, Sambucetti LC, Bair KW, Bontempo J, Cesarz D, Chandramouli N, Chen R, Cheung M, CornellKennon S, Dean K, Diamantidis G, France D, Green MA, Howell KL, Kashi R, Kwon P, Lassota P, Martin MS, Mou
Y, Perez LB, Sharma S, Smith T, Sorensen E, Taplin F, Trogani N, Versace R, Walker H, Weltchek-Engler S, Wood A,
Wu A, Atadja P. N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in
vivo antitumor activity: Discovery of (2e)-n-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1h-indol-3-yl)ethyl] amino]
methyl]-phenyl]-2-propenamide (nvp-laq824). Journal of Medicinal Chemistry. 2003;46:4609-4624
Ren B, O'Brien B, Byrne M, Simpson A. Expression of insulin in the livers of prediabetic non obese diabetic mice
may reduce the development of type i diabetes: 548. Transplantation. 2008;86:192
Ren W, Korchin B, Lahat G, Wei C, Bolshakov S, Nguyen T, Merritt W, Dicker A, Lazar A, Sood A, Pollock RE, Lev
D. Combined vascular endothelial growth factor receptor/epidermal growth factor receptor blockade with
chemotherapy for treatment of local, uterine, and metastatic soft tissue sarcoma. Clin Cancer Res.
2008;14:5466-5475
Reniere ML, Skaar EP. Staphylococcus aureus heme oxygenases are differentially regulated by iron and heme.
Molecular Microbiology. 2008;69:1304-1315
Rettig GR, McAnuff M, Liu D, Kim JS, Rice KG. Quantitative bioluminescence imaging of transgene expression
in vivo. Anal Biochem. 2006;355:90-94
Rettig GR, Rice KG. Quantitative in vivo imaging of non-viral-mediated gene expression and rnai-mediated
knockdown. Bioluminescence. 2009:155-171.
Rettig M, Ritchey J, Prior J, Haug J, Piwnica-Worms D, DiPersio J. Kinetics of in vivo elimination of suicide
gene-expressing t cells affects engraftment, graft-versus-host disease, and graft-versus-leukemia after allogeneic
bone marrow transplantation. The Journal of Immunology. 2004;173:3620
Reumers V, Deroose CM, Krylyshkina O, Nuyts J, Geraerts M, Mortelmans L, Gijsbers R, Van den Haute C,
Debyser Z, Baekelandt V. Noninvasive and quantitative monitoring of adult neuronal stem cell migration in
mouse brain using bioluminescence imaging. Stem Cells. 2008;26:2382-2390
Rice BW, Cable MD, Nelson MB. In vivo imaging of light-emitting probes. J Biomed Opt. 2001;6:432-440
Rice BW, Contag CH. The importance of being red. Nat Biotechnol. 2009;27:624-625
Riedel CU, Casey PG, Mulcahy H, O'Gara F, Gahan CG, Hill C. Construction of p16slux, a novel vector for
improved bioluminescent labeling of gram-negative bacteria. Appl Environ Microbiol. 2007;73:7092-7095
Riedel CU, Monk IR, Casey PG, Morrissey D, O'Sullivan GC, Tangney M, Hill C, Gahan CG. Improved luciferase
2164.
2165.
2166.
2167.
2168.
2169.
2170.
2171.
2172.
2173.
2174.
2175.
2176.
2177.
2178.
2179.
2180.
2181.
2182.
2183.
2184.
2185.
2186.
2187.
2188.
tagging system for listeria monocytogenes allows real-time monitoring in vivo and in vitro. Appl Environ
Microbiol. 2007;73:3091-3094
Riedel CU, Monk IR, Casey PG, Waidmann MS, Gahan CG, Hill C. Agrd-dependent quorum sensing affects
biofilm formation, invasion, virulence and global gene expression profiles in listeria monocytogenes. Mol
Microbiol. 2009;71:1177-1189
Ripp S, Jegier P, Johnson CM, Brigati JR, Sayler GS. Bacteriophage-amplified bioluminescent sensing of
escherichia coli o157:H7. Anal Bioanal Chem. 2008
Ritchie JP, Ramani VC, Ren Y, Naggi A, Torri G, Casu B, Penco S, Pisano C, Carminati P, Tortoreto M, Zunino F,
Vlodavsky I, Sanderson RD, Yang Y. Sst0001, a chemically modified heparin, inhibits myeloma growth and
angiogenesis via disruption of the heparanase/syndecan-1 axis. Clinical cancer research : an official journal of
the American Association for Cancer Research. 2011;17:1382-1393
Rivera A, Collins N, Stephan MT, Lipuma L, Leiner I, Pamer EG. Aberrant tissue localization of fungus-specific
cd4+ t cells in il-10-deficient mice1. Journal of Immunology. 2009;183:631-641
Rivera R, Hutchens M, Luker KE, Sonstein J, Curtis JL, Luker GD. Murine alveolar macrophages limit replication
of vaccinia virus. Virology. 2007;363:48-58
Robb RJ, Kreijveld E, Kuns RD, Wilson YA, Olver SD, Don AL, Raffelt NC, De Weerd NA, Lineburg KE, Varelias A,
Markey KA, Koyama M, Clouston AD, Hertzog PJ, Macdonald KP, Hill GR. Type i interferons control gvhd and
gvl responses after transplantation. Blood. 2011
Robbins D, Zhao Y. Imaging nf-kappab signaling in mice for screening anticancer drugs. Methods Mol Biol.
2011;716:169-177
Roberts ES, Malstrom SE, Dreher KL. In situ pulmonary localization of air pollution particle-induced oxidative
stress. Journal of Toxicology and Environmental Health - Part A: Current Issues. 2007;70:1929-1935
Robertson R, Germanos MS, Li C, Mitchell GS, Cherry SR, Silva MD. Optical imaging of cerenkov light
generation from positron-emitting radiotracers. Physics in Medicine and Biology. 2009;54:N355-365
Roccaro AM, Sacco A, Thompson B, Leleu X, Azab AK, Azab F, Runnels J, Jia X, Ngo HT, Melhem MR, Lin CP,
Ribatti D, Rollins BJ, Witzig TE, Anderson KC, Ghobrial IM. Micrornas 15a and 16 regulate tumor proliferation
in multiple myeloma. Blood. 2009;113:6669-6680
Rocchetta HL, Boylan CJ, Foley JW, Iversen PW, LeTourneau DL, McMillian CL, Contag PR, Jenkins DE, Parr TR.
Validation of a noninvasive, real-time imaging technology using bioluminescent escherichia coli in the
neutropenic mouse thigh model of infection. Antimicrobial Agents and Chemotherapy. 2001;45:129-137
Rodrigo-Garzon M, Berraondo P, Ochoa L, Zulueta JJ, Gonzalez-Aseguinolaza G. Antitumoral efficacy of DNA
nanoparticles in murine models of lung cancer and pulmonary metastasis. Cancer Gene Ther. 2009
Rodriguez-Madoz J, Casales E, Guan M, Prieto J, Smerdou C. Antitumoral effect mediated by two sfv-il-12
expression vectors in a murine model of colon adenocarcinoma. Molecular Therapy. 2004;9:S217-S218
Rodriguez-Madoz J, Prieto J, Smerdou C. Semliki forest virus vectors engineered to express higher il-12 levels
induce efficient elimination of murine colon adenocarcinomas. Molecular Therapy. 2005;12:153-163
Rodriguez-Madoz J, Prieto J, Smerdou C. Biodistribution and tumor infectivity of semliki forest virus vectors in
mice: Effects of re-administration. Molecular Therapy. 2007;15:2164-2171
Rodriguez-Porcel M, Gheysens O, Chen IY, Wu JC, Gambhir SS. Image-guided cardiac cell delivery using highresolution small-animal ultrasound. Molecular Therapy. 2005;12:1142-1147
Roebuck BD, Johnson DN, Sutter CH, Egner PA, Scholl PF, Friesen MD, Baumgartner KJ, Ware NM, Bodreddigari
S, Groopman JD, Kensler TW, Sutter TR. Transgenic expression of aflatoxin aldehyde reductase (akr7a1)
modulates aflatoxin b1 metabolism but not hepatic carcinogenesis in the rat. Toxicological Sciences.
2009;109:41-49
Roescher N, Vosters JL, Yin H, Illei GG, Tak PP, Chiorini JA. Effect of soluble icam-1 on a sjogren's syndromelike phenotype in nod mice is disease stage dependent. PloS one. 2011;6:e19962
Roland CL, Dineen SP, Toombs JE, Carbon JG, Smith CW, Brekken RA, Barnett CC, Jr. Tumor-derived
intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic
xenografts. Exp Biol Med (Maywood). 2010;235:263-270
Rooney PJ, Neal LM, Knoll LJ. Involvement of a toxoplasma gondii chromatin remodeling complex ortholog in
developmental regulation. PloS one. 2011;6:e19570
Roos AK, Eriksson F, Timmons JA, Gerhardt J, Nyman U, Gudmundsdotter L, Bråve A, Wahren B, Pisa P. Skin
electroporation: Effects on transgene expression, DNA persistence and local tissue environment. PLoS One.
2009;4
Roos AK, Eriksson F, Walters DC, Pisa P, King AD. Optimization of skin electroporation in mice to increase
tolerability of DNA vaccine delivery to patients. Mol Ther. 2009;17:1637-1642
Rosas-Taraco AG, Higgins DM, Sánchez-Campillo J, Lee EJ, Orme IM, González-Juarrero M. Intrapulmonary
delivery of xcl1-targeting small interfering rna in mice chronically infected with mycobacterium tuberculosis.
American Journal of Respiratory Cell and Molecular Biology. 2009;41:136-145
Rosati SF, Williams RF, Nunnally LC, McGee MC, Sims TL, Tracey L, Zhou J, Fan M, Ng CY, Nathwani AC, Stewart
CF, Pfeffer LM, Davidoff AM. Ifn-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by
modulating o6-methylguanine DNA methyltransferase expression. Mol Cancer Ther. 2008;7:3852-3858
Rosati SF, Williams RF, Nunnally LC, McGee MC, Sims TL, Tracey L, Zhou J, Fan M, Ng CY, Nathwani AC, Stewart
CF, Pfeffer LM, Davidoff AM. Interferon-β sensitizes neuroblastoma to the anti-tumor activity of temozolomide
2189.
2190.
2191.
2192.
2193.
2194.
2195.
2196.
2197.
2198.
2199.
2200.
2201.
2202.
2203.
2204.
2205.
2206.
2207.
2208.
2209.
2210.
2211.
2212.
2213.
by modulating o6-methylguanine-DNA methyltransferase expression. Mol Cancer Ther. 2008;7:3852-3858
Rosol TJ, Tannehill-Gregg SH, LeRoy BE, Mandl S, Contag CH. Animal models of bone metastasis. Cancer.
2003;97:748-757
Rosowski EE, Lu D, Julien L, Rodda L, Gaiser RA, Jensen KD, Saeij JP. Strain-specific activation of the nf-kappab
pathway by gra15, a novel toxoplasma gondii dense granule protein. The Journal of experimental medicine.
2011;208:195-212
Roth DJ, Jansen ED, Powers AC, Wang TG. A novel method of monitoring response to islet transplantation:
Bioluminescent imaging of an nf-kb transgenic mouse model. [article]. Transplantation. 2006
Rothbard JB, Jones LR. Quantitation of cellular and topical uptake of luciferin–oligoarginine conjugates.
Methods Mol Biol. 2011;683:487-504
Roufosse C, Bou-Gharios G, Prodromidi E, Alexakis C, Jeffery R, Khan S, Otto W, Alter J, Poulsom R, Cook H.
Bone marrow-derived cells do not contribute significantly to collagen i synthesis in a murine model of renal
fibrosis. Journal of the American Society of Nephrology. 2006;17:775
Rozniecki JJ, Sahagian GG, Tao K, Jacobson S, Kempuraj D, Theoharides TC. Acute stress magnifies brain
metastases of mammary adenocarcinoma cells in mice. Journal of the Neurological Sciences. 2009;285:S235
Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, Schmidt K, Kieran MW, Luster AD, Segal RA. A small-molecule
antagonist of cxcr4 inhibits intracranial growth of primary brain tumors. Proceedings of the National Academy
of Sciences of the United States of America. 2003;100:13513-13518
Ruggiero A, Holland JP, Lewis JS, Grimm J. Cerenkov luminescence imaging of medical isotopes. Journal of
nuclear medicine : official publication, Society of Nuclear Medicine. 2010;51:1123-1130
Rutschmann S, Hoebe K, Zalevsky J, Du X, Mann N, Dahiyat B, Steed P, Beutler B. Panr1, a dominant negative
missense allele of the gene encoding tnf-{alpha}(tnf), does not impair lymphoid development. The Journal of
Immunology. 2006;176:7525-7532
Ryan A, Scrable H. Visualization of the dynamics of gene expression in the living mouse. Mol Imaging.
2004;3:33-42
Ryan PL, Youngblood RC, Harvill J, Willard ST. Photonic monitoring in real time of vascular endothelial growth
factor receptor 2 gene expression under relaxin-induced conditions in a novel murine wound model. Ann NY
Acad Sci. 2005;1041:398-414
Ryman KD, Gardner CL, Burke CW, Meier KC, Thompson JM, Klimstra WB. Heparan sulfate binding can
contribute to the neurovirulence of neuroadapted and nonneuroadapted sindbis viruses▿. J Virol.
2007;81:3563-3573
Ryman KD, Gardner CL, Meier KC, Biron CA, Johnston RE, Klimstra WB. Early restriction of alphavirus
replication and dissemination contributes to age-dependent attenuation of systemic hyperinflammatory disease.
J Gen Virol. 2007;88:518-529
Saad M, Garbuzenko OB, Ber E, Chandna P, Khandare JJ, Pozharov VP, Minko T. Receptor targeted polymers,
dendrimers, liposomes: Which nanocarrier is the most efficient for tumor-specific treatment and imaging? J
Control Release. 2008;130:107-114
Sacca R, Engle SJ, Qin W, Stock JL, McNeish JD. Genetically engineered mouse models in drug discovery
research. Mouse models for drug discovery. 2010:37-54.
Sacco A, Doyonnas R, Kraft P, Vitorovic S, Blau HM. Self-renewal and expansion of single transplanted muscle
stem cells. Nature. 2008;456:502-506
Sadikot RT, Blackwell TS. Bioluminescence imaging. Proc Am Thorac Soc. 2005;2:537-540
Sadikot RT, Blackwell TS. Bioluminescence: Imaging modality for in vitro and in vivo gene expression. Methods
Mol Biol. 2008;477:383-394
Saeij J, Boyle J, Boothroyd J. Differences among the three major strains of toxoplasma gondii and their specific
interactions with the infected host. TRENDS in Parasitology. 2005;21:476-481
Saeij JP, Arrizabalaga G, Boothroyd JC. A cluster of four surface antigen genes specifically expressed in
bradyzoites, sag2cdxy, plays an important role in toxoplasma gondii persistence. Infect Immun.
2008;76:2402-2410
Saeij JPJ, Boyle JP, Grigg ME, Arrizabalaga G, Boothroyd JC. Bioluminescence imaging of toxoplasma gondii
infection in living mice reveals dramatic differences between strains. Infection and Immunity. 2005;73:695-702
Safran M, Kim WY, Kung AL, Horner JW, DePinho RA, Kaelin WG, Jr. Mouse reporter strain for noninvasive
bioluminescent imaging of cells that have undergone cre-mediated recombination. Mol Imaging.
2003;2:297-302
Safran M, Kim WY, O'Connell F, Flippin L, Gunzler V, Horner JW, DePinho RA, Kaelin WG, Jr. From the cover:
Mouse model for noninvasive imaging of hif prolyl hydroxylase activity: Assessment of an oral agent that
stimulates erythropoietin production. PNAS. 2006;103:105-110
Safran M, Kim WY, O'Connell F, Flippin L, Günzler V, Horner JW, DePinho RA, Kaelin WG. Mouse model for
noninvasive imaging of hif prolyl hydroxylase activity: Assessment of an oral agent that stimulates
erythropoietin production. Proceedings of the National Academy of Sciences of the United States of America.
2006;103:105-110
Saito Y, Furukawa T, Arano Y, Fujibayashi Y, Saga T. Comparison of semiquantitative fluorescence imaging and
pet tracer uptake in mesothelioma models as a monitoring system for growth and therapeutic effects. Nuclear
Medicine and Biology. 2008;35:851-860
2214.
Sakaguchi M, Kataoka K, Abarzua F, Tanimoto R, Watanabe M, Murata H, Than SS, Kurose K, Kashiwakura Y,
Ochiai K, Nasu Y, Kumon H, Huh N. Overexpression of reic/dkk-3 in normal fibroblasts suppresses tumor growth
via induction of interleukin-7*s . Journal of Biological Chemistry. 2009;284:14236-14244
2215.
Salsman VS, Chow KK, Shaffer DR, Kadikoy H, Li XN, Gerken C, Perlaky L, Metelitsa LS, Gao X, Bhattacharjee M,
Hirschi K, Heslop HE, Gottschalk S, Ahmed N. Crosstalk between medulloblastoma cells and endothelium
triggers a strong chemotactic signal recruiting t lymphocytes to the tumor microenvironment. PloS one.
2011;6:e20267
Samarsky D, Taylor M, Kay M, McCaffrey A. Rnai in drug development: Practical considerations. In: Appasani K,
ed. Rna interference technology: From basic science to drug development. Cambridge Books; 2005:384-395.
Sambanthamoorthy K, Zembruski B, Nguyen D, Stoodley P, Joshi P, Murata H, Koespel R, Russell A, Nowatzki P,
Hortelano E, Ehrlich G. Assessment of biofilm formation by luminescent bacteria and evaluation of bactericidal
activity using a high-throughput biofilm testing method. Abstracts of the General Meeting of the American
Society for Microbiology. 2008;108:544
Samudio I, Harmancey R, Fiegl M, Kantarjian H, Konopleva M, Korchin B, Kaluarachchi K, Bornmann W, Duvvuri
S, Taegtmeyer H, Andreeff M. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells
to apoptosis induction. Journal of Clinical Investigation. 2010;120:142-156
Sandhu U, Cebula M, Behme S, Riemer P, Wodarczyk C, Metzger D, Reimann J, Schirmbeck R, Hauser H, Wirth D.
Strict control of transgene expression in a mouse model for sensitive biological applications based on rmce
compatible es cells. Nucleic acids research. 2011;39:e1
Sanjiv K, Su TL, Suman S, Kakadiya R, Lai TC, Wang HY, Hsiao M, Lee TC. The novel DNA alkylating agent
bo-1090 suppresses the growth of human oral cavity cancer in xenografted and orthotopic mouse models.
International journal of cancer. Journal international du cancer. 2011
Sano D, Choi S, Milas ZL, Zhou G, Galer CE, Su YW, Gule M, Zhao M, Zhu Z, Myers JN. The effect of combination
anti-endothelial growth factor receptorr and anti-vascular endgthelial growth factor receptor 2 targeted therap on
lymph node metastasis: A study in an orthotopic nude mouse model of squamous cell carcinoma of the
oraltongue. Archives of Otolaryngology -- Head and Neck Surgery. 2009;135:411-420
Sano D, Matsumoto F, Valdecanas DR, Zhao M, Molkentine DP, Takahashi Y, Hanna EY, Papadimitrakopoulou V,
Heymach J, Milas L, Myers JN. Vandetanib restores head and neck squamous cell carcinoma cells' sensitivity to
cisplatin and radiation in vivo and in vitro. Clinical cancer research : an official journal of the American
Association for Cancer Research. 2011;17:1815-1827
Sano D, Myers JN. Xenograft models of head and neck cancers. Head Neck Oncol. 2009;1:32
Santos EB, Yeh R, Lee J, Nikhamin Y, Punzalan B, La Perle K, Larson SM, Sadelain M, Brentjens RJ. Sensitive in
vivo imaging of t cells utilizing a membrane bound gaussia princeps luciferase enzyme. Nature Medicine.
2009;15:338-344
Santos K, Simon DA, Conway E, Bowers WJ, Mitra S, Foster TH, Lugade A, Lord EM, Federoff HJ, Dewhurst S,
Frelinger JG. Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes:
Implications for their use as immunization vectors. Human Gene Therapy. 2007;18:93-105
Sanz P, Teel LD, Alem F, Carvalho HM, Darnell SC, O'Brien AD. Detection of bacillus anthracis spore germination
in vivo by bioluminescence imaging. Infection and Immunity. 2008;76:1036-1047
Sapra P, Kraft P, Pastorino F, Ribatti D, Dumble M, Mehlig M, Wang M, Ponzoni M, Greenberger LM, Horak ID.
Potent and sustained inhibition of hif-1alpha and downstream genes by a polyethyleneglycol-sn38 conjugate,
ezn-2208, results in anti-angiogenic effects. Angiogenesis. 2011;14:245-253
Sapra P, Zhang Y, Castaneda S, Kim S, Kraft P, Bandaru R, Greenberger LM, Horak ID. A locked nucleic acid
antisense oligonucleotode against androgen receptor, down-modulates target mrna and causes antitumor effects
in xenograft models of prostate cancer. Mol Cancer Ther. 2009;8
Saqib A, Prasad KM, Katwal AB, Sanders JM, Lye RJ, French BA, Annex BH. Adeno-associated virus serotype 9mediated overexpression of extracellular superoxide dismutase improves recovery from surgical hind-limb
ischemia in balb/c mice. Journal of vascular surgery : official publication, the Society for Vascular Surgery
[and] International Society for Cardiovascular Surgery, North American Chapter. 2011
Saraswati S, Alfaro MP, Thorne CA, Atkinson J, Lee E, Young PP. Pyrvinium, a potent small molecule wnt
inhibitor, promotes wound repair and post-mi cardiac remodeling. PLoS ONE. 2010
Sarkaria J, Yang L, Grogan P, Kitange G, Carlson B, Schroeder M, Galanis E, Giannini C, Wu W, Dinca E.
Identification of molecular characteristics correlated with glioblastoma sensitivity to egfr kinase inhibition
through use of an intracranial xenograft test panel. Mol Cancer Ther. 2007;6:1167
Sarkioja M, Kanerva A, Salo J, Kangasniemi L, Eriksson M, Raki M, Ranki T, Hakkarainen T, Hemminki A.
Noninvasive imaging for evaluation of the systemic delivery of capsid-modified adenoviruses in an orthotopic
model of advanced lung cancer. Cancer. 2006;107:1578-1588
Sarraf-Yazdi S, Mi J, Dewhirst M, Clary B. Use of bioluminescence imaging to detect enhanced hepatic and
systemic tumor growth following partial hepatectomy in mice. European Journal of Surgical Oncology (EJSO).
2008;34:476-481
Sarraf-Yazdi S, Mi J, Dewhirst MW, Clary BM. Use of in vivo bioluminescence imaging to predict hepatic tumor
burden in mice. J Surg Res. 2004;120:249-255
Sarraf-Yazdi S, Mi J, Moeller BJ, Niu X, White RR, Kontos CD, Sullenger BA, Dewhirst MW, Clary BM. Inhibition
of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific rna aptamer. J
2216.
2217.
2218.
2219.
2220.
2221.
2222.
2223.
2224.
2225.
2226.
2227.
2228.
2229.
2230.
2231.
2232.
2233.
2234.
2235.
2236.
2237.
2238.
2239.
2240.
2241.
2242.
2243.
2244.
2245.
2246.
2247.
2248.
2249.
2250.
2251.
2252.
2253.
2254.
2255.
2256.
2257.
2258.
2259.
2260.
Surg Res. 2008
Sasaki A, Oshima Y, Fujimura A. An approach to elucidate potential mechanism of renal toxicity of arsenic
trioxide. Experimental Hematology. 2007;35:252-262
Sato A, Klaunberg B, Tolwani R. In vivo bioluminescence imaging. Comp Med. 2004;54:631-634
Sato A, Ohtsuki M, Hata M, Kobayashi E, Murakami T. Antitumor activity of ifn-lambda in murine tumor models.
J Immunol. 2006;176:7686-7694
Sato K, Kimura S, Segawa H, Yokota A, Matsumoto S, Kuroda J, Nogawa M, Yuasa T, Kiyono Y, Wada H. Cytotoxic
effects of gammadelta t cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy.
International Journal of Cancer. 2005;116:94-99
Sato K, Kimura S, Yuasa T, Wada H, Maekawa T. Cancer immunotherapy: Cytotoxic activity of gamma delta t-cells
expanded ex vivo by the third generation bisphosphonate zoledronate. Blood. 2004;104:379A
Sato K, Yuasa T, Nogawa M, Kimura S, Segawa H, Yokota A, Maekawa T. A third-generation bisphosphonate,
minodronic acid (ym529), successfully prevented the growth of bladder cancer in vitro and in vivo. British
Journal of Cancer. 2006;95:1354-1361
Sato M, Figueiredo M, Burton J, Johnson M, Chen M, Powell R, Gambhir S, Carey M, Wu L. Configurations of a
two-tiered amplified gene expression system in adenoviral vectors designed to improve the specificity of in vivo
prostate cancer imaging. Gene Therapy. 2008;15:583-593
Sato M, Johnson M, Zhang L, Gambhir SS, Carey M, Wu L. Functionality of androgen receptor–based gene
expression imaging in hormone refractory prostate cancer. Clinical Cancer Research. 2005;11:3743
Sato M, Johnson M, Zhang L, Zhang B, Le K, Gambhir SS, Carey M, Wu L. Optimization of adenoviral vectors to
direct highly amplified prostate-specific expression for imaging and gene therapy. Mol Ther. 2003;8:726
Sato T, Ramsubir S, Higuchi K, Yanagisawa T, Medin J. Vascular endothelial growth factor broadens lentivector
distribution in the heart after neonatal injection. Journal of Cardiology. 2009;54:245-254
Sato Y, Ajiki T, Inoue S, Fujishiro J, Yoshino H, Igarashi Y, Hakamata Y, Kaneko T, Murakamid T, Kobayashi E.
Gene silencing in rat-liver and limb grafts by rapid injection of small interference rna. Transplantation.
2005;79:240-243
Sato Y, Ajiki T, Inoue S, Hakamata Y, Murakami T, Kaneko T, Takahashi M, Kobayashi E. A novel gene therapy to
the graft organ by a rapid injection of naked DNA i: Long-lasting gene expression in a rat model of limb
transplantation. Transplantation. 2003;76:1294
Sato Y, Endo H, Ajiki T, Hakamata Y, Okada T, Murakami T, Kobayashi E. Establishment of cre/loxp
recombination system in transgenic rats. Biochem Biophys Res Commun. 2004;319:1197-1202
Satterwhite T, Chong A, Luo J, Pham H, Costa M, Longaker M, Wyss-Coray T, Chang J. Continuous live imaging
of tgf-beta activity using a novel transgenic mouse wound-healing model. Plastic and Reconstructive Surgery.
2006;118:66
Satterwhite T, Chong A, Luo J, Pham H, Costa M, Longaker M, Wyss-Coray T, Chang J. In vitro analysis of
transforming growth factor-[beta] 1 inhibition in novel transgenic sbe-luciferase mice. Annals of Plastic
Surgery. 2007;59:207
Sauvageot CME, Weatherbee JL, Kesari S, Winters SE, Barnes J, Dellagatta J, Ramakrishna NR, Stiles CD, Kung
ALJ, Kieran MW, Wen PYC. Efficacy of the hsp90 inhibitor 17-aag in human glioma cell lines and tumorigenic
glioma stem cells. Neuro Oncol. 2009;11:109-121
Savard C, Guerin A, Drouin K, Bolduc M, Laliberte-Gagne ME, Dumas MC, Majeau N, Leclerc D. Improvement of
the trivalent inactivated flu vaccine using papmv nanoparticles. PloS one. 2011;6:e21522
Savla R, Taratula O, Garbuzenko O, Minko T. Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin
conjugate for imaging and treatment of cancer. Journal of controlled release : official journal of the Controlled
Release Society. 2011;153:16-22
Savoldo B, Rooney CM, Di Stasi A, Abken H, Hombach A, Foster AE, Zhang L, Heslop HE, Brenner MK, Dotti G.
Epstein barr virus–specific cytotoxic t lymphocytes expressing the anti-cd30ζ artificial chimeric t-cell receptor
for immunotherapy of hodgkin disease. Blood. 2007;110:2620-2630
Sawada R, Peterson CY, Gonzalez AM, Potenza BM, Mueller B, Coimbra R, Eliceiri BP, Baird A. A phage-targeting
strategy for the design of spatiotemporal drug delivery from grafted matrices. Fibrogenesis & tissue repair.
2011;4:7
Saydam O, Glauser D, Heid I, Turkeri G, Hilbe M, Jacobs A, Ackermann M, Fraefel C. Herpes simplex virus 1
amplicon vector-mediated sirna targeting epidermal growth factor receptor inhibits growth of human glioma
cells in vivo. Molecular Therapy. 2005;12:803-812
Scabini M, Stellari F, Cappella P, Rizzitano S, Texido G, Pesenti E. In vivo imaging of early stage apoptosis by
measuring real-time caspase-3/7 activation. Apoptosis. 2010:1-10
Scarlett UK, Cubillos-Ruiz JR, Nesbeth YC, Martinez DG, Engle X, Gewirtz AT, Ahonen CL, Conejo-Garcia JR. In
situ stimulation of cd40 and toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from
immunosuppressive to immunostimulatory cells. Cancer Res. 2009;69:7329-7337
Scatena CD, Hepner MA, Oei YA, Dusich JM, Yu SF, Purchio T, Contag PR, Jenkins DE. Imaging of
bioluminescent lncap-luc-m6 tumors: A new animal model for the study of metastatic human prostate cancer.
Prostate. 2004;59:292-303
Scheffold C, Kornacker M, Scheffold YC, Contag CH, Negrin RS. Visualization of effective tumor targeting by
cd8+ natural killer t cells redirected with bispecific antibody f(ab')(2)her2xcd3. Cancer Res. 2002;62:5785-5791
2261.
2262.
2263.
2264.
2265.
2266.
2267.
2268.
2269.
2270.
2271.
2272.
2273.
2274.
2275.
2276.
2277.
2278.
2279.
2280.
2281.
2282.
2283.
2284.
2285.
Scheiman J, Tseng JC, Zheng Y, Meruelo D. Multiple functions of the 37/67-kd laminin receptor make it a
suitable target for novel cancer gene therapy. Mol Ther. 2009
Scherer RL, VanSaun MN, McIntyre O, Matrisian LM. Optical imaging of matrix metalloproteinase-7 activity in
vivo using a proteolytic nanobeacon. Mol Imaging. 2008;7:118-131
Schimmelpfennig CH, Schulz S, Arber C, Baker J, Tarner I, McBride J, Contag CH, Negrin RS. Ex vivo expanded
dendritic cells home to t-cell zones of lymphoid organs and survive in vivo after allogeneic bone marrow
transplantation. American Journal of Pathology. 2005;167:1321-1331
Schipper M, Patel M, Gambhir S. Evaluation of firefly luciferase bioluminescence mediated photodynamic
toxicity in cancer cells. Molecular Imaging and Biology. 2006;8:218-225
Schluep T, Hwang J, Cheng J, Heidel J, Bartlett D, Hollister B, Davis M. Preclinical efficacy of the camptothecinpolymer conjugate it-101 in multiple cancer models. Clinical Cancer Research. 2006;12:1606
Schneider A, Kalikin LM, Mattos AC, Keller ET, Allen MJ, Pienta KJ, McCauley LK. Bone turnover mediates
preferential localization of prostate cancer in the skeleton. Endocrinology. 2005;146:1727-1736
Schneider MR, Dahlhoff M, Horst D, Hirschi B, Trülzsch K, Müller-Höcker J, Vogelmann R, Allgäuer M, Gerhard
M, Steininger S, Wolf E, Kolligs FT. A key role for e-cadherin in intestinal homeostasis and paneth cell
maturation PLoS ONE. 2010
Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspurner H, Robbins R, Pelletier M. Simplified protocol to
isolate, purify, and culture expand mesenchymal stem cells. Stem Cells Dev. 2007;16:105-108
Schrepfer S, Deuse T, Reichenspurner H, Fischbein MP, Robbins RC, Pelletier MP. Stem cell transplantation: The
lung barrier. Transplant Proc. 2007;39:573-576
Schuele G, Vitkin E, Huie P, O’Connell-Rodwell C, Palanker D, Perelman L. Optical spectroscopy noninvasively
monitors response of organelles to cellular stress. Journal of biomedical optics. 2005;10:051404
Schuetz E, Lan L, Yasuda K, Kim R, Kocarek TA, Schuetz J, Strom S. Development of a real-time in vivo
transcription assay: Application reveals pregnane x receptor-mediated induction of cyp3a4 by cancer
chemotherapeutic agents. Mol Pharmacol. 2002;62:439-445
Schultz GM, Tedesco MM, Miyama N, Li Z, Asagami T, Dalman RL. In situ bioluminescence imaging of
progenitor cells in experimental abdominal aortic aneurysm (aaa) disease. Arteriosclerosis, Thrombosis, and
Vascular Biology. 2008;28:e149
Schwan WR, Lehmann L, McCormick J. Transcriptional activation of the staphylococcus aureus putp gene by
low-proline-high osmotic conditions and during infection of murine and human tissues. Infection and Immunity.
2006;74:399-409
Schwandt T, Juengerkes F, Schumak B, Holzmann B, Layland L, Limmer A. Long-term effects of sepsis: The
influence of bacteremia and bacterial translocation on systemic adaptive immune responses. Inflammation
Research. 2010;59:s15
Schweichel D, Steitz J, Tormo D, Gaffal E, Ferrer A, Buchs S, Speuser P, Limmer A, Tuting T. Evaluation of DNA
vaccination with recombinant adenoviruses using bioluminescence imaging of antigen expression: Impact of
application routes and delivery with dendritic cells. J Gene Med. 2006;8:1243-1250
Schwerdt A, Zintchenko A, Concia M, Roesen N, Fisher KD, Lindner LH, Issels RD, Wagner E, Ogris M.
Hyperthermia induced targeting of thermosensitive gene carriers to tumors. Hum Gene Ther. 2008
Scotti ML, Bamlet WR, Smyrk TC, Fields AP, Murray NR. Protein kinase c{iota} is required for pancreatic cancer
cell transformed growth and tumorigenesis. Cancer Res. 2010;70:2064-2074
Scull B, Rigby RJ, Newton VA, Hamilton K, Morgan D, Lund PK. Intestinal epithelial cell (iec)-specific deletion
of suppressor of cytokine signaling 3 (socs3) in interleukin-10 null mice promotes duodenal tumors
independent of inflammation: Detection with a cathepsin-b activatable molecular probe. Gastroenterology.
2009;136:A114
Seavey MM, Maciag PC, Al-Rawi N, Sewell D, Paterson Y. An anti-vascular endothelial growth factor receptor 2/
fetal liver kinase-1 listeria monocytogenes anti-angiogenesis cancer vaccine for the treatment of primary and
metastatic her-2/neu+ breast tumors in a mouse model1. Journal of Immunology. 2009;182:5537-5546
Seavey MM, Pan ZK, Maciag PC, Wallecha A, Rivera S, Paterson Y, Shahabi V. A novel human her-2/neu chimeric
molecule expressed by listeria monocytogenes can elicit potent hla-a2 restricted cd8-positive t cell responses
and impact the growth and spread of her-2/neu-positive breast tumors. Clin Cancer Res. 2009;15:924-932
Sedgley CM, Nagel AC, Hall D, Applegate B. Influence of irrigant needle depth in removing bioluminescent
bacteria inoculated into instrumented root canals using real-time imaging in vitro. Int Endod J. 2005;38:97-104
Seelbach M, Chen L, Powell A, Choi YJ, Zhang B, Hennig B, Toborek M. Polychlorinated biphenyls disrupt
blood–brain barrier integrity and promote brain metastasis formation. Environmental Health Perspectives.
2010;118:479-484
Seethammagari MR, Xie X, Greenberg NM, Spencer DM. Ezc-prostate models offer high sensitivity and specificity
for noninvasive imaging of prostate cancer progression and androgen receptor action. Cancer Res.
2006;66:6199-6209
Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M,
Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL,
Freeman ML, Blackwell TS. Nadph oxidase limits innate immune responses in the lungs in mice. PLoS One.
2010;5
Seleem M, Ali M, Boyle S, Sriranganathan N. Reporter genes for real-time in vivo monitoring of ochrobactrum
2286.
2287.
2288.
2289.
2290.
2291.
2292.
2293.
2294.
2295.
2296.
2297.
2298.
2299.
2300.
2301.
2302.
2303.
2304.
2305.
2306.
2307.
2308.
2309.
2310.
2311.
2312.
anthropi infection. FEMS Microbiology Letters. 2008;286:124-129
Sellins K, Fradkin L, Liggitt D, Dow S. Type i interferons potently suppress gene expression following gene
delivery using liposome(-)DNA complexes. Mol Ther. 2005;12:451-459
Selvam S, Kundu K, Templeman KL, Murthy N, Garcia AJ. Minimally invasive, longitudinal monitoring of
biomaterial-associated inflammation by fluorescence imaging. Biomaterials. 2011
Semprini S, Friedrichsen S, Harper CV, McNeilly JR, Adamson AD, Spiller DG, Kotelevtseva N, Brooker G,
Brownstein DG, McNeilly AS, White MR, Davis JR, Mullins JJ. Real-time visualisation of human prolactin
alternate promoter usage in vivo using a double-transgenic rat model. Molecular Endocrinology.
2009;23:529-538
Serganova I, Moroz E, Vider J, Gogiberidze G, Moroz M, Pillarsetty N, Doubrovin M, Minn A, Thaler HT,
Massague J, Gelovani J, Blasberg R. Multimodality imaging of tgf{beta} signaling in breast cancer metastases.
Faseb J. 2009
Serrano LM, Pfeiffer T, Olivares S, Numbenjapon T, Bennitt J, Kim D, Smith D, McNamara G, Al-Kadhimi Z,
Rosenthal J, Forman SJ, Jensen MC, Cooper LJN. Differentiation of naive cord-blood t cells into cd19-specific
cytolytic effectors for posttransplantation adoptive immunotherapy. Blood. 2006;107:2643-2652
Serwer L, Hashizume R, Ozawa T, James CD. Systemic and local drug delivery for treating diseases of the central
nervous system in rodent models. J Vis Exp. 2010:e1992
Sethi N, Dai X, Winter CG, Kang Y. Tumor-derived jagged1 promotes osteolytic bone metastasis of breast cancer
by engaging notch signaling in bone cells. Cancer cell. 2011;19:192-205
Shachaf CM, Kopelman AM, Arvanitis C, Karlsson A, Beer S, Mandl S, Bachmann MH, Borowsky AD, Ruebner B,
Cardiff RD, Yang Q, Bishop JM, Contag CH, Felsher DW. Myc inactivation uncovers pluripotent differentiation
and tumour dormancy in hepatocellular cancer. Nature. 2004;431:1112-1117
Shah A, Parker J, Gillespie G, Lakeman F, Meleth S, Markert J, Cassady K. Enhanced antiglioma activity of
chimeric hcmv/hsv-1 oncolytic viruses. Gene Therapy. 2007;14:1045-1054
Shah K. In vivo imaging of the dynamics of different variants of egfr in glioblastomas. Methods Mol Biol.
2011;680:153-164
Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin D. Oct1 loss of function induces a coordinate
metabolic shift that opposes tumorigenicity. Nat Cell Biol. 2009;11:320-327
Shan L, Wang S, Korotcov A, Sridhar R, Wang PC. Bioluminescent animal models of human breast cancer for
tumor biomass evaluation and metastasis detection. Ethn Dis. 2008;18:S2-65-69
Shan L, Zhang R, Zhang W, Lee E, Sridhar R, Snyderwine EG, Wang PC. Image-based evaluation of the molecular
events underlying hc11 mammary epithelial cell differentiation. Analytical Biochemistry. 2008;382:122-128
Shani N, Shani Z, Shoseyov O, Mruwat R, Shoseyov D. Oxidized cellulose binding to allergens with a
carbohydrate-binding module attenuates allergic reactions. Journal of immunology. 2011;186:1240-1247
Shao Q, Jiang T, Ren G, Cheng Z, Xing B. Photoactivable bioluminescent probes for imaging luciferase activity.
Chem Commun (Camb). 2009:4028-4030
Shapira Y, Katz M, Ali M, Kaplan M, Brazowski E, Halpern Z, Elinav E. Utilization of murine laparoscopy for
continuous in-vivo assessment of the liver in multiple disease models. PLoS One. 2009;4
Sharma P, Singh R, Novakovic K, Grizzle W, Singh S. Significance of ccr9-ccl25 axis in prostate cancer
metastasis. Journal of Urology. 2010;183:e550
Shcherbo D, Shemiakina, II, Ryabova AV, Luker KE, Schmidt BT, Souslova EA, Gorodnicheva TV, Strukova L,
Shidlovskiy KM, Britanova OV, Zaraisky AG, Lukyanov KA, Loschenov VB, Luker GD, Chudakov DM. Nearinfrared fluorescent proteins. Nat Methods. 2010;7:827-829
Sheel M, Pandey M, Good MF, Batzloff MR. Passive protection in mice challenged with a recombinant
bioluminescent m49 group a streptococcus strain: Correlation between bioluminescence and bacterial burden.
Clin Vaccine Immunol. 2009
Sheel M, Pandey M, Good MF, Batzloff MR. Correlation between bioluminescence and bacterial burden in
passively protected mice challenged with a recombinant bioluminescent m49 group a streptococcus strain. Clin
Vaccine Immunol. 2010;17:127-133
Sheikh A, Lin S, Cao F, Cao Y, van der Bogt K, Chu P, Chang C, Contag C, Robbins R, Wu J. Molecular imaging of
bone marrow mononuclear cell homing and engraftment in ischemic myocardium. Stem Cells.
2007;25:2677-2684
Shelton LM, Huysentruyt LC, Mukherjee P, Seyfried TN. Calorie restriction as an anti-invasive therapy for
malignant brain cancer in the vm mouse. ASN Neuro. 2010;2
Shelton LM, Huysentruyt LC, Seyfried TN. Glutamine targeting inhibits systemic metastasis in the vm-m3
murine tumor model. Int J Cancer. 2010
Shen S, Bryant KD, Brown SM, Randell SH, Asokan A. Terminal n-linked galactose is the primary receptor for
adeno-associated virus 9. The Journal of biological chemistry. 2011;286:13532-13540
Sher F, van Dam G, Boddeke E, Copray S. Bioluminescence imaging of olig2-neural stem cells reveals improved
engraftment in a demyelination mouse model. Stem Cells. 2009;27:1582-1591
Sher YP, Liu SJ, Chang CM, Lien SP, Chen CH, Han Z, Li LY, Chen JS, Wu CW, Hung MC. Cancer-targeted bikdd
gene therapy elicits protective antitumor immunity against lung cancer. Mol Cancer Ther. 2011;10:637-647
Sher YP, Tzeng TF, Kan SF, Hsu J, Xie X, Han Z, Lin WC, Li LY, Hung MC. Cancer targeted gene therapy of bikdd
inhibits orthotopic lung cancer growth and improves long-term survival. Oncogene. 2009;28:3286-3295
2313.
2314.
2315.
2316.
2317.
2318.
2319.
2320.
2321.
2322.
2323.
2324.
2325.
2326.
2327.
2328.
2329.
2330.
2331.
2332.
2333.
2334.
2335.
2336.
2337.
2338.
2339.
Shi C, Zhu Y, Xie Z, Qian W, Hsieh CL, Nie S, Su Y, Zhau HE, Chung LW. Visualizing human prostate cancer cells
in mouse skeleton using bioconjugated near-infrared fluorescent quantum dots. Urology. 2009;74:446-451
Shi L, Takahashi K, Dundee J, Shahroor-Karni S, Thiel S, Jensenius JC, Gad F, Hamblin MR, Sastry KN, Ezekowitz
RAB. Mannose-binding lectin-deficient mice are susceptible to infection with staphylococcus aureus. Journal of
Experimental Medicine. 2004;199:1379-1390
Shih C, Laurie N, Holzmacher J, Davidoff A, Dyer M. Aav-mediated delivery of interferon-{beta} for the treatment
of retinoblastoma in preclinical models. Neuromolecular Med. 2007;11:43-52
Shih CS, Laurie N, Holzmacher J, Spence Y, Nathwani AC, Davidoff AM, Dyer MA. Aav-mediated local delivery of
interferon-beta for the treatment of retinoblastoma in preclinical models. Neuromolecular Med. 2009;11:43-52
Shin S, Shea LD. Lentivirus immobilization to nanoparticles for enhanced and localized delivery from hydrogels.
Mol Ther. 2010;18:700-706
Shinde R, Perkins J, Contag CH. Luciferin derivatives for enhanced in vitro and in vivo bioluminescence assays.
Biochemistry. 2006;45:11103-11112
Shiozawa Y, Pedersen EA, Patel LR, Ziegler AM, Havens AM, Jung Y, Wang J, Zalucha S, Loberg RD, Pienta KJ,
Taichman RS. Gas6/axl axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow
niche. Neoplasia. 2010;12:116-127
Shirota H, Petrenko L, Hattori T, Klinman DM. Contribution of irf-3 mediated ifnβ production to DNA vaccine
dependent cellular immune responses. Vaccine. 2009;27:2144-2149
Shlomai A, Paran N, Shaul Y. Pgc-1alpha controls hepatitis b virus through nutritional signals. Proc Natl Acad
Sci U S A. 2006;103:16003-16008
Shoji M, Sun A, Kisiel W, Lu YJ, Shim H, McCarey BE, Nichols C, Parker ET, Pohl J, Mosley CA, Alizadeh AR,
Liotta DC, Snyder JP. Targeting tissue factor-expressing tumor angiogenesis and tumors with ef24 conjugated to
factor viia. J Drug Target. 2008;16:185-197
Shu CJ, Guo S, Kim YJ, Shelly SM, Nijagal A, Ray P, Gambhir SS, Radu CG, Witte ON. Visualization of a primary
anti-tumor immune response by positron emission tomography. Proceedings of the National Academy of
Sciences of the United States of America. 2005;102:17412-17417
Shu ST, Nadella MV, Dirksen WP, Fernandez SA, Thudi NK, Werbeck JL, Lairmore MD, Rosol TJ. A novel
bioluminescent mouse model and effective therapy for adult t-cell leukemia/lymphoma. Cancer Res.
2007;67:11859-11866
Siegers GM, Felizardo TC, Mathieson AM, Kosaka Y, Wang XH, Medin JA, Keating A. Anti-leukemia activity of in
vitro-expanded human gamma delta t cells in a xenogeneic ph+ leukemia model. PloS one. 2011;6:e16700
Siggs OM, Berger M, Krebs P, Arnold CN, Eidenschenk C, Huber C, Pirie E, Smart NG, Khovananth K, Xia Y,
McInerney G, Karlsson Hedestam GB, Nemazee D, Beutler B. A mutation of ikbkg causes immune deficiency
without impairing degradation of iκbα. Proceedings of the National Academy of Sciences of the United States of
America. 2010;107:3046-3051
Silberhumer GR, Brader P, Wong J, Serganova IS, Gonen M, Gonzalez SJ, Blasberg R, Zamarin D, Fong Y.
Genetically engineered oncolytic newcastle disease virus effectively induces sustained remission of malignant
pleural mesothelioma. Mol Cancer Ther. 2010;9:2761-2769
Silvertown J, Ng J, Sato T, Summerlee A, Medin J. H2 relaxin overexpression increases in vivo prostate xenograft
tumor growth and angiogenesis. International Journal of Cancer. 2006;118:62-73
Silvertown J, Walia J, Summerlee A, Medin J. Functional expression of mouse relaxin and mouse relaxin-3 in the
lung from an ebola virus glycoprotein-pseudotyped lentivirus via tracheal delivery. Endocrinology.
2006;147:3797
Sim H, Bibee K, Wickline S, Sept D. Pharmacokinetic modeling of tumor bioluminescence implicates efflux, and
not influx, as the bigger hurdle in cancer drug therapy. Cancer Res. 2011;71:686-692
Simeonov A. Moving and glowing transporters: Commentary. Assay and Drug Development Technologies.
2007;5:485-487
Sims TL, Hamner JB, Bush RA, Fischer PE, Kim SU, Aboody KS, McCarville B, Danks MK, Davidoff AM. Neural
progenitor cell-mediated delivery of osteoprotegerin limits disease progression in a pre-clinical model of
neuroblastoma bone metastasis. Journal of Pediatric Surgery. 2009;44:204-211
Sims TL, Jr., Hamner JB, Bush RA, Williams RF, Zhou J, Kim SU, Aboody KS, Danks MK, Davidoff AM. Neural
progenitor cell-mediated delivery of interferon beta improves neuroblastoma response to cyclophosphamide.
Ann Surg Oncol. 2008;15:3259-3267
Sims TL, Williams RF, Ng CY, Rosati SF, Spence Y, Davidoff AM. Bevacizumab suppresses neuroblastoma
progression in the setting of minimal disease. Surgery. 2008;144:269-275
Singh B, Berry J, Shoher A, Lucci A. Cox-2 induces il-11 production in human breast cancer cells. Journal of
Surgical Research. 2006;131:267-275
Singh B, Berry JA, Shoher A, Ayers GD, Wei C, Lucci A. Cox-2 involvement in breast cancer metastasis to bone.
Oncogene. 2007
Singh B, Berry JA, Vincent LE, Lucci A. Involvement of il-8 in cox-2-mediated bone metastases from breast
cancer. Journal of Surgical Research. 2006;134:44-51
Singh B, Vincent L, Berry J, Multani A, Lucci A. Cyclooxygenase-2 expression induces genomic instability in
mcf10a breast epithelial cells. Journal of Surgical Research. 2007;140:220-226
Singh H, Figliola MJ, Dawson MJ, Huls H, Olivares S, Switzer K, Mi T, Maiti S, Kebriaei P, Lee DA, Champlin RE,
2340.
2341.
2342.
2343.
2344.
2345.
2346.
2347.
2348.
2349.
2350.
2351.
2352.
2353.
2354.
2355.
2356.
2357.
2358.
2359.
2360.
2361.
2362.
2363.
2364.
2365.
2366.
2367.
2368.
Cooper LJ. Reprogramming cd19-specific t cells with il-21 signaling can improve adoptive immunotherapy of blineage malignancies. Cancer Res. 2011;71:3516-3527
Singh H, Najjar AM, Olivares S, Nishii R, Mukhopadhyay U, Alauddin M, Manuri PR, Huls H, Lee DA, Dotti G,
Bollard C, Simmons PJ, Shpall EJ, Champlin RE, Gelovani JG, Cooper LJ. Pet imaging of t cells derived from
umbilical cord blood. Leukemia. 2008;23:620-622
Singh H, Serrano LM, Pfeiffer T, Olivares S, McNamara G, Smith DD, Al-Kadhimi Z, Forman SJ, Gillies SD, Jensen
MC, Colcher D, Raubitschek A, Cooper LJ. Combining adoptive cellular and immunocytokine therapies to
improve treatment of b-lineage malignancy. Cancer Res. 2007;67:2872-2880
Singh PP, Joshi S, Russell PJ, Verma ND, Wang X, Khatri A. Molecular chemotherapy and chemotherapy: A new
front against late-stage hormone-refractory prostate cancer. Clinical cancer research : an official journal of the
American Association for Cancer Research. 2011;17:4006-4018
Sinn P, Arias A, Brogden K, McCray Jr P. Successful re-administration of lentiviral vector to nasal epithelia
without blocking immune responses. J Virol. 2008
Sinn PL, Arias AC, Brogden KA, McCray PB, Jr. Lentivirus vector can be readministered to nasal epithelia without
blocking immune responses. J Virol. 2008;82:10684-10692
Sinn PL, Burnight ER, Hickey MA, Blissard GW, McCray PB. Persistent gene expression in mouse nasal epithelia
following feline immunodeficiency virus-based vector gene transfer. J Virol. 2005;79:12818-12827
Siprashvili Z, Scholl F, Oliver S, Adams A, Contag C, Wender P, Khavari P. Gene transfer via reversible plasmid
condensation with cysteine-flanked, internally spaced arginine-rich peptides. Human Gene Therapy.
2003;14:1225-1233
Sista AK, Knebel RJ, Tavri S, Johansson M, DeNardo DG, Boddington SE, Kishore SA, Ansari C, Reinhart V,
Coakley FV, Coussens LM, Daldrup-Link HE. Optical imaging of the peri-tumoral inflammatory response in
breast cancer. J Transl Med. 2009;7:94
Sjölinder H, Jonsson A-B. Olfactory nerve—a novel invasion route of neisseria meningitidis to reach the
meninges. PLoS ONE. 2010
Sjölinder H, Jonsson AB. Imaging of disease dynamics during meningococcal sepsis. PLoS One. 2007;2
Sjollema J, Sharma PK, Dijkstra RJ, van Dam GM, van der Mei HC, Engelsman AF, Busscher HJ. The potential for
bio-optical imaging of biomaterial-associated infection in vivo. Biomaterials. 2010;31:1984-1995
Skelding KA, Barry RD, Shafren DR. Systemic targeting of metastatic human breast tumor xenografts by
coxsackievirus a21. Breast Cancer Res Treat. 2009;113:21-30
Slavin AJ, Tarner IH, Nakajima A, Urbanek-Ruiz I, McBride J, Contag CH, Fathman CG. Adoptive cellular gene
therapy of autoimmune disease. Autoimmun Rev. 2002;1:213-219
Sleator RD. Probiotic therapy - recruiting old friends to fight new foes. Gut Pathog. 2010;2:5
Small GW, Bookheimer SY, Thompson PM, Cole GM, Huang SC, Kepe V, Barrio JR. Current and future uses of
neuroimaging for cognitively impaired patients. Lancet Neurol. 2008;7:161-172
Smith AJ, Karpova Y, D'Agostino R, Willingham M, Kulik G. Expression of the bcl-2 protein bad promotes
prostate cancer growth. PLoS One. 2009;4
Smith BD. Storable near-infrared chemilumilescent probes for in vivo optical imaging. Proceedings SPIE.
2011;7910
Smith FJ, Hickerson RP, Sayers JM, Reeves RE, Contag CH, Leake D, Kaspar RL, McLean WH. Development of
therapeutic sirnas for pachyonychia congenita. Journal of Investigative Dermatology. 2008;128:50-58
Smith MC, Luker KE, Garbow JR, Prior JL, Jackson E, Piwnica-Worms D, Luker GD. Cxcr4 regulates growth of
both primary and metastatic breast cancer. Cancer Res. 2004;64:8604-8612
Smith MW, Schmidt JE, Rehg JE, Orihuela CJ, McCullers JA. Induction of pro- and anti-inflammatory molecules
in a mouse model of pneumococcal pneumonia after influenza. Comp Med. 2007;57:82-89
Smith P, Oakley F, Fernandez M, Mann D, Lemoine N, Whitehouse A. Herpesvirus saimiri-based vector
biodistribution using noninvasive optical imaging. Gene Therapy. 2005;12:1465-1476
Smith SJ, Zhang H, Clermont AO, Powers AC, Kaufman DB, Purchio AF, West DB. In vivo monitoring of
pancreatic beta-cells in a transgenic mouse model. Mol Imaging. 2006;5:65-75
Snoeks TJ, Lowik CW, Kaijzel EL. 'In vivo' optical approaches to angiogenesis imaging. Angiogenesis. 2010
So M-K, Xu C, Loening AM, Gambhir SS, Rao J. Self-illuminating quantum dot conjugates for in vivo imaging.
Nat Biotech. 2006;24:339-343
So MK, Gowrishankar G, Hasegawa S, Chung JK, Rao J. Imaging target mrna and sirna-mediated gene silencing in
vivo with ribozyme-based reporters. Chembiochem. 2008;9:2682-2691
So MK, Loening AM, Gambhir SS, Rao J. Creating self-illuminating quantum dot conjugates. Nat Protoc.
2006;1:1160-1164
Sofia Vala I, Martins LR, Imaizumi N, Nunes RJ, Rino J, Kuonen F, Carvalho LM, Rüegg C, Grillo IM, Barata JT,
Mareel M, Santos SCR. Low doses of ionizing radiation promote tumor growth and metastasis by enhancing
angiogenesis. PLoS One. 2010;5
Somjen D, Katzburg S, Nevo N, Gayer B, Hodge RP, Renevey MD, Kalchenko V, Meshorer A, Stern N, Kohen F. A
daidzein-daunomycin conjugate improves the therapeutic response in an animal model of ovarian carcinoma. J
Steroid Biochem Mol Biol. 2008;110:144-149
Sommereyns C, Paul S, Staeheli P, Michiels T. Ifn-lambda (ifn-λ) is expressed in a tissue-dependent fashion and
primarily acts on epithelial cells in vivo. PLoS Pathog. 2008;4
2369.
2370.
2371.
2372.
2373.
2374.
2375.
2376.
2377.
2378.
2379.
2380.
2381.
2382.
2383.
2384.
2385.
2386.
2387.
2388.
2389.
2390.
2391.
2392.
2393.
2394.
Song H, Shahverdi K, Huso DL, Wang Y, Fox JJ, Hobbs RF, Gimi B, Gabrielson KL, Pomper MG, Tsui BM,
Bhujwalla Z, Reilly RT, Sgouros G. An immunotolerant her-2/neu transgenic mouse model of metastatic breast
cancer. Clinical Cancer Research. 2008;14:6116-6124
Song HT, Jordan EK, Lewis BK, Liu W, Ganjei J, Klaunberg B, Despres D, Palmieri D, Frank JA. Rat model of
metastatic breast cancer monitored by mri at 3 tesla and bioluminescence imaging with histological correlation. J
Transl Med. 2009;7:88
Sonveaux P, Végran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, De Saedeleer CJ, Kennedy KM, Diepart C,
Jordan BF, Kelley MJ, Gallez B, Wahl ML, Feron O, Dewhirst MW. Targeting lactate-fueled respiration selectively
kills hypoxic tumor cells in mice. Journal of Clinical Investigation. 2008;118:3930-3942
Sottnik JL, U'Ren LW, Thamm DH, Withrow SJ, Dow SW. Chronic bacterial osteomyelitis suppression of tumor
growth requires innate immune responses. Cancer Immunol Immunother. 2010;59:367-378
Souris JS, Lee CH, Cheng SH, Chen CT, Yang CS, Ho JA, Mou CY, Lo LW. Surface charge-mediated rapid
hepatobiliary excretion of mesoporous silica nanoparticles. Biomaterials. 2010;31:5564-5574
Spaccapelo R, Aime E, Caterbi S, Arcidiacono P, Capuccini B, Di Cristina M, Dottorini T, Rende M, Bistoni F,
Crisanti A. Disruption of plasmepsin-4 and merozoites surface protein-7 genes in plasmodium berghei induces
combined virulence-attenuated phenotype. Sci. Rep. 2011;1
Spaccapelo R, Janse CJ, Caterbi S, Franke-Fayard B, Bonilla JA, Syphard LM, Di Cristina M, Dottorini T, Savarino
A, Cassone A, Bistoni F, Waters AP, Dame JB, Crisanti A. Plasmepsin 4-deficient plasmodium berghei are
virulence attenuated and induce protective immunity against experimental malaria. Am J Pathol.
2010;176:205-217
Spaeth EL, Dembinski JL, Sasser AK, Watson K, Klopp A, Hall B, Andreeff M, Marini F. Mesenchymal stem cell
transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor
progression. PLoS One. 2009;4
Spaeth EL, Marini FC. Dissecting mesenchymal stem cell movement: Migration assays for tracing and deducing
cell migration. Methods Mol Biol. 2011;750:241-259
Sparatore A, Perrino E, Tazzari V, Giustarini D, Rossi R, Rossoni G, Erdman K, Schroder H, Del Soldato P.
Pharmacological profile of a novel h(2)s-releasing aspirin. Free Radic Biol Med. 2009;46:586-592
Spillman MA, Manning NG, Dye WW, Sartorius CA, Post MD, Harrell JC, Jacobsen BM, Horwitz KB. Tissuespecific pathways for estrogen regulation of ovarian cancer growth and metastasis. Cancer Res.
2010;70:8927-8936
Spillman MA, Sartorius CA, Harrell JC, Manning N, Jacobsen BM, Horwitz KB. Estrogen replacement therapy
promotes extraperitoneal lymph node metastases in a mouse xenograft ovarian cancer model. Gynecologic
Oncology. 2009;112:S184-S185
Spinelli A, D'Ambrosio D, Calderan L, Marengo M, Sbarbati A, Boschi F. In vivo optical imaging using cerenkov
radiation. Physics in Medicine and Biology. 2010;55:483-495
Spinelli AE, D'Ambrosio D, Calderan L, Marengo M, Sbarbati A, Boschi F. Cerenkov radiation allows in vivo
optical imaging of positron emitting radiotracers. Phys Med Biol. 2010;55:483-495
Spinelli AE, Kuo C, Rice BW, Calandrino R, Marzola P, Sbarbati A, Boschi F. Multispectral cerenkov
luminescence tomography for small animal optical imaging. Optics express. 2011;19:12605-12618
Spiotto MT, Banh A, Papandreou I, Cao H, Galvez MG, Gurtner GC, Denko NC, Le QT, Koong AC. Imaging the
unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict
tumor growth. Cancer Res. 2010;70:78-88
Srikumar S, Fuchs TM. Ethanolamine utilization contributes to proliferation of salmonella enterica serovar
typhimurium in food and in nematodes. Applied and environmental microbiology. 2011;77:281-290
Stabenow D, Frings M, Truck C, Gartner K, Forster I, Kurts C, Tuting T, Odenthal M, Dienes HP, Cederbrant K,
Protzer U, Knolle PA. Bioluminescence imaging allows measuring cd8 t cell function in the liver. Hepatology.
2010;51:1430-1437
Stafford JH, Thorpe PE. Increased exposure of phosphatidylethanolamine on the surface of tumor vascular
endothelium. Neoplasia. 2011;13:299-308
Stan SD, Hahm ER, Warin R, Singh SV. Withaferin a causes foxo3a- and bim-dependent apoptosis and inhibits
growth of human breast cancer cells in vivo. Cancer Res. 2008;68:7661-7669
Stanley P. Late abstracts for the 12th international symposium on bioluminescence and chemiluminescence held
at robinson college, university of cambridge, england, 5-9 april 2002. Luminescence. 2002;17:355-361
Stastny M, Brown C, Ruel C, Jensen M. Medulloblastomas expressing il13r [alpha] 2 are targets for il13-zetakine
+ cytolytic t cells. Journal of Pediatric Hematology/Oncology. 2007;29:669
Stathopoulos G, Kollintza A, Moschos C, Psallidas I, Sherrill T, Pitsinos E, Vassiliou S, Karatza M, Papiris S, Graf
D. Tumor necrosis factor promotes malignant pleural effusion. Cancer Res. 2007;67:9825
Stathopoulos GT, Sherrill TP, Han W, Sadikot RT, Polosukhin VV, Fingleton B, Yull FE, Blackwell TS. Use of
bioluminescent imaging to investigate the role of nuclear factor-kappabeta in experimental non-small cell lung
cancer metastasis. Clin Exp Metastasis. 2008;25:43-51
Stathopoulos GT, Zhu Z, Everhart MB, Kalomenidis I, Lawson WE, Bilaceroglu S, Peterson TE, Mitchell D, Yull
FE, Light RW, Blackwell TS. Nuclear factor-{kappa}b affects tumor progression in a mouse model of malignant
pleural effusion. Am. J. Respir. Cell Mol. Biol. 2005:2005-0130OC
Stathopoulos GT, Zhu Z, Everhart MB, Kalomenidis I, Lawson WE, Bilaceroglu S, Peterson TE, Mitchell D, Yull
2395.
2396.
2397.
2398.
2399.
2400.
2401.
2402.
2403.
2404.
2405.
2406.
2407.
2408.
2409.
2410.
2411.
2412.
2413.
2414.
2415.
2416.
2417.
2418.
2419.
FE, Light RW, Blackwell TS. Nuclear factor-κb affects tumor progression in a mouse model of malignant pleural
effusion. American Journal of Respiratory Cell and Molecular Biology. 2006;34:142-150
Stauff DL, Skaar EP. Bacillus anthracis hssrs signaling to hrtab regulates heme resistance during infection.
Molecular Microbiology. 2009;72:763-778
Stefflova K, Chen J, Li H, Zheng G. Targeted photodynamic therapy agent with a built-in apoptosis sensor for in
vivo near-infrared imaging of tumor apoptosis triggered by its photosensitization in situ. Molecular Imaging.
2006;5:520
Stefflova K, Li H, Chen J, Zheng G. Peptide-based pharmacomodulation of a cancer-targeted optical imaging and
photodynamic therapy agent. Bioconjugate Chemistry. 2007;18:379-388
Stegmaier K, Wong JS, Ross KN, Chow KT, Peck D, Wright RD, Lessnick SL, Kung AL, Golub TR. Signature-based
small molecule screening identifies cytosine arabinoside as an ews/fli modulator in ewing sarcoma. PLoS Med.
2007;4
Steiner D, Gelovani J, Savoldo B, Robinson SN, Decker WK, Brouard N, Najjar A, Xing D, Yang H, Li S, Marini F,
Zweidler-McKay PA, Bollard CM, Shpall EJ, Dotti G, Simmons PJ. Noninvasive bioluminescent imaging
demonstrates long-term multilineage engraftment of ex vivo-expanded cd34-selected umbilical cord blood cells.
Stem Cells. 2009
Steinhuber A, Landmann R, Goerke C, Wolz C, Fluckiger U. Bioluminescence imaging to study the promoter
activity of hla of staphylococcus aureus in vitro and in vivo. Int J Med Microbiol. 2008;298:599-605
Stell A, Belcredito S, Ramachandran B, Biserni A, Rando G, Ciana P, Maggi A. Multimodality imaging: Novel
pharmacological applications of reporter systems. Q J Nucl Med Mol Imaging. 2007;51:127-138
Stendahl JC, Wang LJ, Chow LW, Kaufman DB, Stupp SI. Growth factor delivery from self-assembling nanofibers
to facilitate islet transplantation. Transplantation. 2008;86:478-481
Stephan D, Slabber C, George G, Ninov V, Francis KP, Burger JT. Visualization of plant viral suppressor silencing
activity in intact leaf lamina by quantitative fluorescent imaging. Plant methods. 2011;7:25
Stephan MT, Ponomarev V, Brentjens RJ, Chang AH, Dobrenkov KV, Heller G, Sadelain M. T cell-encoded cd80
and 4-1bbl induce auto- and transcostimulation, resulting in potent tumor rejection. Nat Med.
2007;13:1440-1449
Stish BJ, Oh S, Chen H, Dudek AZ, Kratzke RA, Vallera DA. Design and modification of egf4kdel 7mut, a novel
bispecific ligand-directed toxin, with decreased immunogenicity and potent anti-mesothelioma activity. British
Journal of Cancer. 2009;101:1114-1123
Stish BJ, Oh S, Vallera DA. Anti-glioblastoma effect of a recombinant bispecific cytotoxin cotargeting human
il-13 and egf receptors in a mouse xenograft model. J Neurooncol. 2008;87:51-61
Stocking KL, Jones JC, Everds NE, Buetow BS, Roudier MP, Miller RE. Use of low-molecular–weight heparin to
decrease mortality in mice after intracardiac injection of tumor cells. Comp Med. 2009;59:37-45
Stokstad E. Humane science finds sharper and kinder tools. Science. 1999;286:1068-1071
Stout DB, Chatziioannou AF, Lawson TP, Silverman RW, Gambhir SS, Phelps ME. Small animal imaging center
design: The facility at the ucla crump institute for molecular imaging. Molecular Imaging and Biology.
2005;7:393-402
Streck CJ, Dickson PV, Ng CYC, Zhou J, Gray JT, Nathwani AC, Davidoff AM. Adeno-associated virus vectormediated systemic delivery of ifn-{beta} combined with low-dose cyclophosphamide affects tumor regression in
murine neuroblastoma models. Clin Cancer Res. 2005;11:6020-6029
Streicher JM, Kamei K, Ishikawa TO, Herschman H, Wang Y. Compensatory hypertrophy induced by ventricular
cardiomyocyte-specific cox-2 expression in mice. J Mol Cell Cardiol. 2010
Stricklett P, Taylor D, Nelson R, Kohan D. Thick ascending limb-specific expression of cre recombinase.
American Journal of Physiology- Renal Physiology. 2003;285:33
Stubbs MC, Kim YM, Krivtsov AV, Wright RD, Feng Z, Agarwal J, Kung AL, Armstrong SA. Mll-af9 and flt3
cooperation in acute myelogenous leukemia: Development of a model for rapid therapeutic assessment.
Leukemia. 2007
Su EC, Johnson KL, Tighiouart H, Bianchi DW. Murine maternal cell microchimerism: Analysis using real-time
pcr and in vivo imaging. Biol Reprod. 2008;78:883-887
Su H, van Dam GM, Buis CI, Visser DS, Hesselink JW, Schuurs TA, Leuvenink HGD, Contag CH, Porte RJ.
Spatiotemporal expression of heme oxygenase-1 detected by in vivo bioluminescence after hepatic ischemia in
ho-1/luc mice. Liver Transplantation. 2006;12:1634-1639
Su W, Zhou M, Zheng Y, Fan Y, Wang L, Han Z, Kong D, Zhao RC, Wu JC, Xiang R, Li Z. Bioluminescence reporter
gene imaging characterize human embryonic stem cell-derived teratoma formation. Journal of cellular
biochemistry. 2011;112:840-848
Su Y, Luo X, He BC, Wang Y, Chen L, Zuo GW, Liu B, Bi Y, Huang J, Zhu GH, He Y, Kang Q, Luo J, Shen J, Chen J,
Jin X, Haydon RC, He TC, Luu HH. Establishment and characterization of a new highly metastatic human
osteosarcoma cell line. Clin Exp Metastasis. 2009;26:599-610
Su YC, Chuang KH, Wang YM, Cheng CM, Lin SR, Wang JY, Hwang JJ, Chen BM, Chen KC, Roffler S, Cheng TL.
Gene expression imaging by enzymatic catalysis of a fluorescent probe via membrane-anchored betaglucuronidase. Gene Ther. 2007
Subramaniam D, Ramalingam S, Stoner GD, Sureban SM, Houchen CW, Ramanujam RP, Anant S. A novel in vitro
detection method to identify dietary chemopreventive agents utilizing the nf-kappa b pathway.
2420.
2421.
2422.
2423.
2424.
2425.
2426.
2427.
2428.
2429.
2430.
2431.
2432.
2433.
2434.
2435.
2436.
2437.
2438.
2439.
2440.
2441.
2442.
2443.
2444.
2445.
Gastroenterology. 2008;134:A286
Suffner J, Hochweller K, Kuhnle MC, Li X, Kroczek RA, Garbi N, Hammerling GJ. Dendritic cells support
homeostatic expansion of foxp3+ regulatory t cells in foxp3.Lucidtr mice. J Immunol. 2010;184:1810-1820
Sugiyama T, Kuroda S, Osanai T, Shichinohe H, Kuge Y, Ito M, Kawabori M, Iwasaki Y. Near-infrared fluorescence
labeling allows noninvasive tracking of bone marrow stromal cells transplanted into rat infarct brain.
Neurosurgery. 2011;68:1036-1047; discussion 1047
Sulaimon SS, Rosner A, Namba R, Gregg JP, Young LJT, Cardiff RD, Borowsky AD. Metastatic syngeneic mouse
mammary carcinoma bearing a luciferase gfp reporter. FASEB Journal. 2005;19:A1517
Sun A, Hou L, Prugpichailers T, Dunkel J, Kalani MA, Chen X, Kalani MY, Tse V. Firefly luciferase-based dynamic
bioluminescence imaging: A noninvasive technique to assess tumor angiogenesis. Neurosurgery.
2010;66:751-757; discussion 757
Sun C, Liu H, Pratx G, Carpenter C, Xing L, Cheng Z. Mo e 204c 08: Characterization of cerenkov optical
irradiation from radioactive probes in phantoms and living subjects. Medical Physics. 2010;37:3358
Sun CK, Man K, Ng KT, Ho JW, Lim ZX, Cheng Q, Lo CM, Poon RT, Fan ST. Proline-rich tyrosine kinase 2 (pyk2)
promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-src/erk activation.
Carcinogenesis. 2008;29:2096-2105
Sun H, Pisle S, Gardner ER, Figg WD. Bioluminescent imaging study: Fak inhibitor, pf-562,271, preclinical
study in pc3m-luc-c6 local implant and metastasis xenograft models. Cancer Biology and Therapy.
2010;10:38-43
Sun J, Hakobyan N, Valentino LA, Feldman BL, Samulski RJ, Monahan PE. Intraarticular factor ix protein or gene
replacement protects against development of hemophilic synovitis in the absence of circulating factor ix. Blood.
2008;112:4532-4541
Sun J, Zhao L, Teng L, Lin F, Zhang H, Li Z, Gao Q. Solid tumor-targeted infiltrating cytotoxic t lymphocytes
retained by a superantigen fusion protein. PLoS One. 2011;6:e16642
Sun N, Lee A, Wu JC. Long term non-invasive imaging of embryonic stem cells using reporter genes. Nat Protoc.
2009;4:1192-1201
Sun S, Wang Z. Head neck squamous cell carcinoma c-met(+) cells display cancer stem cell properties and are
responsible for cisplatin-resistance and metastasis. International journal of cancer. Journal international du
cancer. 2011
Sun W, Ziady AG. Real-time imaging of gene delivery and expression with DNA nanoparticle technologies.
Methods Mol Biol. 2009;544:525-546
Sun Y, Schneider A, Jung Y, Wang J, Dai J, Cook K, Osman N, Koh Paige A, Shim H. Skeletal localization and
neutralization of the sdf 1 (cxcl12)/cxcr4 axis blocks prostate cancer metastasis and growth in osseous sites in
vivo. Journal of Bone and Mineral Research. 2005;20:318-329
Sun Z, Wang Y, Fu Q, Zhou Y, Jia S, Du J, Peng J, Yang S, Zhan L. Long--term hepatitis c internal ribosome entry
site--dependent gene expression mediated by phage c31 integrase in mouse model. Antiviral therapy.
2009;14:393-400
Sun Z, Zhang X, Locke JE, Zheng Q, Tachibana S, Diehl AM, Williams GM. Recruitment of host progenitor cells in
rat liver transplants. Hepatology. 2008
Sun ZJ, Wang Y, Cai Z, Chen PP, Tong XJ, Xie D. Involvement of cyr61 in growth, migration, and metastasis of
prostate cancer cells. British Journal of Cancer. 2008;99:1656-1667
Suo G, Jiang Y, Cowan B, Wang JY. Platelet-derived growth factor c is upregulated in human uterine fibroids and
regulates uterine smooth muscle cell growth1. Biology of Reproduction. 2009;81:749-758
Suo G, Sadarangani A, Lamarca B, Cowan B, Wang JY. Murine xenograft model for human uterine fibroids: An in
vivo imaging approach. Reprod Sci. 2009
Surguladze D, Steiner P, Prewett M, Tonra JR. Methods for evaluating effects of an irinotecan + 5-fluorouracil/
leucovorin (ifl) regimen in an orthotopic metastatic colorectal cancer model utilizing in vivo bioluminescence
imaging. Mouse models for drug discovery. 2010:235-252.
Surzyn M, Symes J, Medin JA, Sefton MV. Il-10 secretion increases signal persistence of hema-mmamicroencapsulated luciferase-modified cho fibroblasts in mice. Tissue Eng Part A. 2009;15:127-136
Sutton EJ, Boddington SE, Nedopil AJ, Henning TD, Demos SG, Baehner R, Sennino B, Lu Y, Daldrup-Link HE.
An optical imaging method to monitor stem cell migration in a model of immune-mediated arthritis. Opt Express.
2009;17:24403-24413
Sutton EJ, Henning TD, Pichler BJ, Bremer C, Daldrup-Link HE. Cell tracking with optical imaging. Eur Radiol.
2008;18:2021-2032
Suzuki M, Moriguchi T, Ohneda K, Yamamoto M. Differential contribution of the gata1 gene hematopoietic
enhancer to erythroid differentiation▿†. Molecular and Cellular Biology. 2009;29:1163-1175
Suzuki M, Ohneda K, Hosoya-Ohmura S, Tsukamoto S, Ohneda O, Philipsen S, Yamamoto M. Real-time
monitoring of stress erythropoiesis in vivo using gata1 and beta-globin lcr luciferase transgenic mice. Blood.
2006;108:726-733
Suzuki N, Obara N, Yamamoto M. Use of gene-manipulated mice in the study of erythropoietin gene expression.
Methods in Enzymology. 2007;435:157-177
Suzuki R, Takizawa T, Negishi Y, Hagisawa K, Tanaka K, Sawamura K, Utoguchi N, Nishioka T, Maruyama K. Gene
delivery by combination of novel liposomal bubbles with perfluoropropane and ultrasound. Journal of
2446.
2447.
2448.
2449.
2450.
2451.
2452.
2453.
2454.
2455.
2456.
2457.
2458.
2459.
2460.
2461.
2462.
2463.
2464.
2465.
2466.
2467.
2468.
Controlled Release. 2007;117:130-136
Suzuki R, Takizawa T, Negishi Y, Utoguchi N, Sawamura K, Tanaka K, Namai E, Oda Y, Matsumura Y, Maruyama K.
Tumor specific ultrasound enhanced gene transfer in vivo with novel liposomal bubbles. J Control Release.
2008;125:137-144
Suzuki Y, Zhang S, Kundu P, Yeung A, Robbins R, Yang P. In vitro comparison of the biological effects of three
transfection methods for magnetically labeling mouse embryonic stem cells with ferumoxides. Magnetic
Resonance in Medicine. 2007;57:1173-1179
Svensson RU, Barnes JM, Rokhlin OW, Cohen MB, Henry MD. Chemotherapeutic agents up-regulate the
cytomegalovirus promoter: Implications for bioluminescence imaging of tumor response to therapy. Cancer Res.
2007;67:10445-10454
Swarup V, Phaneuf D, Bareil C, Robertson J, Rouleau GA, Kriz J, Julien JP. Pathological hallmarks of
amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with tdp-43
genomic fragments. Brain : a journal of neurology. 2011
Sweeney TJ, Mailander V, Tucker AA, Olomu AB, Zhang W, Cao Y, Negrin RS, Contag CH. Visualizing the
kinetics of tumor-cell clearance in living animals. Proc Natl Acad Sci U S A. 1999;96:12044-12049
Swijnenburg RJ, Govaert JA, van der Bogt KE, Pearl JI, Huang M, Stein W, Hoyt G, Vogel H, Contag CH, Robbins
RC, Wu JC. Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after
myocardial infarction. Circ Cardiovasc Imaging. 2010;3:77-85
Swijnenburg RJ, Schrepfer S, Cao F, Pearl JI, Xie X, Connolly AJ, Robbins RC, Wu JC. In vivo imaging of
embryonic stem cells reveals patterns of survival and immune rejection following transplantation. Stem Cells
Dev. 2008;17:1023-1029
Swijnenburg RJ, Schrepfer S, Govaert JA, Cao F, Ransohoff K, Sheikh AY, Haddad M, Connolly AJ, Davis MM,
Robbins RC, Wu JC. Immunosuppressive therapy mitigates immunological rejection of human embryonic stem
cell xenografts. Proceedings of the National Academy of Sciences of the United States of America.
2008;105:12991-12996
Symonds EL, Riedel CU, O'Mahony D, Lapthorne S, O'Mahony L, Shanahan F. Involvement of t helper type 17
and regulatory t cell activity in citrobacter rodentium invasion and inflammatory damage. Clinical and
Experimental Immunology. 2009;157:148-154
Szatanik M, Hong E, Ruckly C, Ledroit M, Giorgini D, Jopek K, Nicola MA, Deghmane AE, Taha MK. Experimental
meningococcal sepsis in congenic transgenic mice expressing human transferrin. PloS one. 2011;6:e22210
Szentirmai O, Baker CH, Lin N, Szucs S, Takahashi M, Kiryu S, Kung AL, Mulligan RC, BS C. Noninvasive
bioluminescence imaging of luciferase expressing intracranial u87 xenografts: Correlation with magnetic
resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and
antiangiogenic treatment effect. Neurosurgery. 2006;58:365-372
Szentirmai O, Baker CH, Bullain SS, Lin N, Takahashi M, Folkman J, Mulligan RC, Carter BS. Successful
inhibition of intracranial human glioblastoma multiforme xenograft growth via systemic adenoviral delivery of
soluble endostatin and soluble vascular endothelial growth factor receptor-2: Laboratory investigation. Journal
of Neurosurgery. 2008;108:979-988
Tabibiazar R, Cheung L, Han J, Swanson J, Beilhack A, An A, Dadras SS, Rockson N, Joshi S, Wagner R, Rockson
SG. Inflammatory manifestations of experimental lymphatic insufficiency. PLoS Med. 2006;3
Tafreshi N, Sadeghizadeh M, Emamzadeh R, Ranjbar B, Naderi-Manesh H, Hosseinkhani S. Site-directed
mutagenesis of firefly luciferase: Implication of conserved residue(s) in bioluminescence emission spectra
among firefly luciferases. Biochem J. 2008;412:27-33
Tai CJ, Wu AT, Chiou JF, Jan HJ, Wei HJ, Hsu CH, Lin CT, Chiu WT, Wu CW, Lee HM, Deng WP. The investigation
of mitogen-activated protein kinase phosphatase-1 as a potential pharmacological target in non-small cell lung
carcinomas, assisted by non-invasive molecular imaging. BMC Cancer. 2010;10:95
Takahashi K, Onodera S, Tohyama H, Kwon HJ, Honma K, Yasuda K. In vivo imaging of particle-induced
inflammation and osteolysis in the calvariae of nfκb/luciferase transgenic mice. J Biomed Biotechnol. 2011;2011
Takahashi M, Kido K, Aoi A, Furukawa H, Ono M, Kodama T. Spinal gene transfer using ultrasound and
microbubbles. Journal of Controlled Release. 2007;117:267-272
Takahashi Y, Tsuji O, Kumagai G, Hara CM, Okano HJ, Miyawaki A, Toyama Y, Okano H, Nakamura M.
Comparative study of methods for administering neural stem/progenitor cells to treat spinal cord injury in mice.
Cell transplantation. 2011
Takakura H, Kojima R, Urano Y, Terai T, Hanaoka K, Nagano T. Aminoluciferins as functional bioluminogenic
substrates of firefly luciferase. Chemistry, an Asian journal. 2011;6:1800-1810
Takaoka M, Kim S, Okawa T, Michaylira C, Stairs D, Johnstone C, Andl C, Rhoades B, Lee J, Klein-Szanto A.
Igfbp-3 regulates esophageal tumor growth through igf-dependent and independent mechanisms. Cancer
Biology and Therapy. 2007;6:534
Takeshita F, Hokaiwado N, Honma K, Banas A, Ochiya T. Local and systemic delivery of sirnas for
oligonucleotide therapy. Methods Mol Biol. 2009;487:83-92
Takeshita F, Kodama M, Yamamoto H, Ikarashi Y, Ueda S, Teratani T, Yamamoto Y, Tamatani T, Kanegasaki S,
Ochiya T, Quinn G. Streptozotocin-induced partial beta cell depletion in nude mice without hyperglycaemia
induces pancreatic morphogenesis in transplanted embryonic stem cells. Diabetologia. 2006;49:2948-2958
Takeshita F, Minakuchi Y, Nagahara S, Honma K, Sasaki H, Hirai K, Teratani T, Namatame N, Yamamoto Y, Hanai
2469.
2470.
2471.
2472.
2473.
2474.
2475.
2476.
2477.
2478.
2479.
2480.
2481.
2482.
2483.
2484.
2485.
2486.
2487.
2488.
2489.
2490.
2491.
2492.
2493.
K, Kato T, Sano A, Ochiya T. Efficient delivery of small interfering rna to bone-metastatic tumors by using
atelocollagen in vivo. Proceedings of the National Academy of Sciences of the United States of America.
2005;102:12177-12182
Takeuchi M, Kimura S, Kuroda J, Ashihara E, Kawatani M, Osada H, Umezawa K, Yasui E, Imoto M, Tsuruo T,
Yokota A, Tanaka R, Nagao R, Nakahata T, Fujiyama Y, Maekawa T. Glyoxalase-i is a novel target against bcr-abl
(+) leukemic cells acquiring stem-like characteristics in a hypoxic environment. Cell Death Differ. 2010
Takeuchi Y, Yahagi N, Izumida Y, Nishi M, Kubota M, Teraoka Y, Yamamoto T, Matsuzaka T, Nakagawa Y, Sekiya
M, Iizuka Y, Ohashi K, Osuga JI, Gotoda T, Ishibashi S, Itaka K, Kataoka K, Nagai R, Yamada N, Kadowaki T,
Shimano H. Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1
through proteolytic processing and autoloop regulatory circuit. J Biol Chem. 2010
Talbot LJ, Mi Z, Bhattacharya SD, Kim V, Guo H, Kuo PC. Pharmacokinetic characterization of an rna aptamer
against osteopontin and demonstration of in vivo efficacy in reversing growth of human breast cancer cells.
Surgery. 2011;150:224-230
Tamguney G, Francis KP, Giles K, Lemus A, Dearmond SJ, Prusiner SB. Measuring prions by bioluminescence
imaging. Proc Natl Acad Sci U S A. 2009
Tan YF, Chandrasekharan P, Maity D, Yong CX, Chuang KH, Zhao Y, Wang S, Ding J, Feng SS. Multimodal tumor
imaging by iron oxides and quantum dots formulated in poly (lactic acid)-d-alpha-tocopheryl polyethylene
glycol 1000 succinate nanoparticles. Biomaterials. 2011;32:2969-2978
Tanaka M, Swijnenburg R-J, Gunawan F, Cao Y-A, Yang Y, Caffarelli AD, de Bruin JL, Contag CH, Robbins RC. In
vivo visualization of cardiac allograft rejection and trafficking passenger leukocytes using bioluminescence
imaging. Circulation. 2005;112:I-105-110
Tang CH, Lee JW, Galvez MG, Robillard L, Mole SE, Chapman HA. Murine cathepsin f deficiency causes neuronal
lipofuscinosis and late-onset neurological disease‡. Molecular and Cellular Biology. 2006;26:2309-2316
Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R. In vivo assessment of ras-dependent maintenance of
tumor angiogenesis by real-time magnetic resonance imaging. Cancer Res. 2005;65:8324-8330
Tang Z, Du R, Jiang S, Wu C, Barkauskas DS, Richey J, Molter J, Lam M, Flask C, Gerson S, Dowlati A, Liu L, Lee
Z, Halmos B, Wang Y, Kern JA, Ma PC. Dual met–egfr combinatorial inhibition against t790m-egfr-mediated
erlotinib-resistant lung cancer. British Journal of Cancer. 2008;99:911-922
Tanisaka H, Kizaka-Kondoh S, Makino A, Tanaka S, Hiraoka M, Kimura S. Near-infrared fluorescent labeled
peptosome for application to cancer imaging. Bioconjugate Chemistry. 2007;19:109-117
Tannehill Gregg S, Levine A, Rosol T. Feline head and neck squamous cell carcinoma: A natural model for the
human disease and development of a mouse model. Veterinary and Comparative Oncology. 2006;4:84-97
Tannehill-Gregg S, Levine A, Nadella M, Iguchi H, Rosol T. The effect of zoledronic acid and osteoprotegerin on
growth of human lung cancer in the tibias of nude mice. Clinical and Experimental Metastasis. 2006;23:19-31
Tannous BA. Gaussia luciferase reporter assay for monitoring of biological processes in culture and in vivo. Nat
Protoc. 2009;4:582-591
Tao K, Fang M, Alroy J, Sahagian GG. Imagable 4t1 model for the study of late stage breast cancer. BMC Cancer.
2008;8:228
Tarantal A, Lee C, Jimenez D, Gambhir S, Kohn D, Rossi J, Cherry S. Lentiviral vector gene transfer in monkeys: In
vivo. Detection of gene expression longitudinally using micropet and optical imaging. Molecular Therapy.
2005;11:S288
Tarantal AF, Lee C. Long-term luciferase expression monitored by bioluminescence imaging after aav-mediated
fetal gene delivery in rhesus monkeys (macaca mulatta). Hum Gene Ther. 2009
Tarantal AF, Lee CC, Jimenez DF, Cherry SR. Fetal gene transfer using lentiviral vectors: In vivo detection of
gene expression by micropet and optical imaging in fetal and infant monkeys. Hum Gene Ther. 2006
Tarantal AF, Lee CCI, Itkin-Ansari P. Real-time bioluminescence imaging of macroencapsulated fibroblasts
reveals allograft protection in rhesus monkeys (macaca mulatta). Transplantation. 2009;88:38-41
Taratula O, Garbuzenko O, Savla R, Wang YA, He H, Minko T. Multifunctional nanomedicine platform for cancer
specific delivery of sirna by superparamagnetic iron oxide nanoparticles-dendrimer complexes. Current drug
delivery. 2011;8:59-69
Tarner IH, Slavin AJ, McBride J, Levicnik A, Smith R, Nolan GP, Contag CH, Fathman CG. Treatment of
autoimmune disease by adoptive cellular gene therapy. Ann N Y Acad Sci. 2003;998:512-519
Taubes G. Firefly gene lights up lab animals from inside out. Science. 1997;276:1993
Taylor PA, Ehrhardt MJ, Lees CJ, Tolar J, Weigel BJ, Panoskaltsis-Mortari A, Serody JS, Brinkmann V, Blazar BR.
Insights into the mechanism of fty720 and compatibility with regulatory t cells for the inhibition of graftversus-host disease (gvhd). Blood. 2007;110:3480-3488
Taymans JM, Vandenberghe LH, Haute CV, Thiry I, Deroose CM, Mortelmans L, Wilson JM, Debyser Z,
Baekelandt V. Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain.
Hum Gene Ther. 2007;18:195-206
Tchorsh-Yutsis D, Zlotnikov Klionsky Y, Bachar-Lustig E, Aronovich A, Feine I, Shezen E, Rosen C, Bitcover R,
Eventov-Friedman S, Katchman H, Zangi L, Tal O, Cohen S, Reisner Y. Embryonic pig pancreatic tissue for the
treatment of diabetes: Potential role of immune suppression with "off-the-shelf" third-party regulatory t cells.
Transplantation. 2011;91:398-405
Teitz T, Stanke JJ, Federico S, Bradley CL, Brennan R, Zhang J, Johnson MD, Sedlacik J, Inoue M, Zhang ZM,
2494.
2495.
2496.
2497.
2498.
2499.
2500.
2501.
2502.
2503.
2504.
2505.
2506.
2507.
2508.
2509.
2510.
2511.
2512.
2513.
2514.
2515.
2516.
2517.
2518.
Frase S, Rehg JE, Hillenbrand CM, Finkelstein D, Calabrese C, Dyer MA, Lahti JM. Preclinical models for
neuroblastoma: Establishing a baseline for treatment. PloS one. 2011;6:e19133
Teratani T, Yamamoto H, Aoyagi K, Sasaki H, Asari A, Quinn G, Terada M, Ochiya T. Direct hepatic fate
specification from mouse embryonic stem cells. Hepatology. 2005;41:836-846
Terwey TH, Kim TD, Kochman AA, Hubbard VM, Lu S, Zakrzewski JL, Ramirez-Montagut T, Eng JM, Muriglan SJ,
Heller G, Murphy GF, Liu C, Budak-Alpdogan T, Alpdogan O, van den Brink MRM. Ccr2 is required for cd8induced graft-versus-host disease. Blood. 2005;106:3322-3330
Texier I, Josser V. In vivo imaging of quantum dots. Micro and nano technologies in bioanalysis.
2009:393-406.
Thalhofer CJ, Chen Y, Sudan B, Love-Homan L, Wilson ME. Leukocytes infiltrate the skin and draining lymph
nodes in response to the protozoan leishmania infantum chagasi. Infection and immunity. 2011;79:108-117
Thalhofer CJ, Graff JW, Love-Homan L, Hickerson SM, Craft N, Beverley SM, Wilson ME. In vivo imaging of
transgenic leishmania parasites in a live host. J Vis Exp. 2010:e1980
Thorne S, Tam B, Kirn D, Contag C, Kuo C. Selective intratumoral amplification of an antiangiogenic vector by an
oncolytic virus produces enhanced antivascular and anti-tumor efficacy. Molecular Therapy. 2006;13:938-946
Thorne SH, Barak Y, Liang W, Bachmann MH, Rao J, Contag CH, Matin A. Cnob/chrr6, a new prodrug enzyme
cancer chemotherapy. Mol Cancer Ther. 2009;8:333-341
Thorne SH, Contag CH. Integrating the biological characteristics of oncolytic viruses and immune cells can
optimize therapeutic benefits of cell-based delivery. Gene Ther. 2008
Thorne SH, Hwang THH, O’Gorman WE, Bartlett DL, Sei S, Kanji F, Brown C, Werier J, Cho JH, Lee DE, Wang Y,
Bell J, Kirn DH. Rational strain selection and engineering creates a broad-spectrum, systemically effective
oncolytic poxvirus, jx-963. Journal of Clinical Investigation. 2007;117:3350-3358
Thorne SH, Negrin RS, Contag CH. Synergistic antitumor effects of immune cell-viral biotherapy. Science.
2006;311:1780-1784
Thudi NK, Martin CK, Nadella MV, Fernandez SA, Werbeck JL, Pinzone JJ, Rosol TJ. Zoledronic acid decreased
osteolysis but not bone metastasis in a nude mouse model of canine prostate cancer with mixed bone lesions.
Prostate. 2008;68:1116-1125
Thudi NK, Shu ST, Martin CK, Lanigan LG, Nadella MV, Van Bokhoven A, Werbeck JL, Simmons JK, Murahari S,
Kisseberth WC, Breen M, Williams C, Chen CS, McCauley LK, Keller ET, Rosol TJ. Development of a brain
metastatic canine prostate cancer cell line. Prostate. 2011;71:1251-1263
Tian X, Hexum MK, Penchev VR, Taylor RJ, Shultz LD, Kaufman DS. Bioluminescent imaging demonstrates
transplanted human embryonic stem cell-derived cd34+ cells preferentially develop into endothelial cells. Stem
Cells. 2009;27:2675-2685
Tian X, Woll PS, Morris JK, Linehan JL, Kaufman DS. Hematopoietic engraftment of human embryonic stem cellderived cells is regulated by recipient innate immunity. Stem Cells. 2006:2005-0340
Tiede BJ, Owens LA, Li F, DeCoste C, Kang Y. A novel mouse model for non-invasive single marker tracking of
mammary stem cells in vivo reveals stem cell dynamics throughout pregnancy. PLoS One. 2009;4
Tietge UJF, Maugeais C, Lund-Katz S, Grass D, DeBeer FC, Rader DJ. Human secretory phospholipase a2 mediates
decreased plasma levels of hdl cholesterol and apoa-i in response to inflammation in human apoa-i transgenic
mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:1213-1218
Tiffen JC, Bailey CG, Ng C, Rasko JE, Holst J. Luciferase expression and bioluminescence does not affect tumor
cell growth in vitro or in vivo. Mol Cancer. 2010;9:299
Tillmanns J, Carlsen H, Blomhoff R, Valen G, Calvillo L, Ertl G, Bauersachs J, Frantz S. Caught in the act: In vivo
molecular imaging of the transcription factor nf-kappab after myocardial infarction. Biochem Biophys Res
Commun. 2006;342:773-774
Tirona R, Lee W, Leake B, Lan L, Cline C, Lamba V, Parviz F, Duncan S, Inoue Y, Gonzalez F. The orphan nuclear
receptor hnf4 determines pxr-and car-mediated xenobiotic induction of cyp3a4. Nature Medicine.
2003;9:220-224
Tivnan A, Foley NH, Tracey L, Davidoff AM, Stallings RL. Microrna-184-mediated inhibition of tumour growth
in an orthotopic murine model of neuroblastoma. Anticancer Res. 2010;30:4391-4395
Tivnan A, Tracey L, Buckley PG, Alcock LC, Davidoff AM, Stallings RL. Microrna-34a is a potent tumor
suppressor molecule in vivo in neuroblastoma. BMC cancer. 2011;11:33
Toegel F, Yang Y, Zhang P, Hu Z, Westenfelder C. Bioluminescence imaging to monitor the in vivo distribution
of administered mesenchymal stem cells in acute kidney injury. Am J Physiol Renal Physiol. 2008
Toelen J, Deroose CM, Gijsbers R, Reumers V, Sbragia LN, Vets S, Chitneni SK, Bormans G, Mortelmans L,
Deprest JA, Debyser Z. Fetal gene transfer with lentiviral vectors: Long-term in vivo follow-up evaluation in a rat
model. Am J Obstet Gynecol. 2007;196:352 e351-356
Toffanin S, Hoshida Y, Lachenmayer A, Villanueva A, Cabellos L, Minguez B, Savic R, Ward SC, Thung S, Chiang
DY, Alsinet C, Tovar V, Roayaie S, Schwartz M, Bruix J, Waxman S, Friedman SL, Golub T, Mazzaferro V, Llovet
JM. Microrna-based classification of hepatocellular carcinoma and oncogenic role of mir-517a.
Gastroenterology. 2011;140:1618-1628 e1616
Tolar J, Nauta AJ, Osborn MJ, Panoskaltsis Mortari A, McElmurry RT, Bell S, Xia L, Zhou N, Riddle M, Schroeder
TM, Westendorf JJ, McIvor RS, Hogendoorn PC, Szuhai K, Oseth L, Hirsch B, Yant SR, Kay MA, Peister A,
Prockop DJ, Fibbe WE, Blazar BR. Sarcoma derived from cultured mesenchymal stem cells. Stem Cells.
2519.
2520.
2521.
2522.
2523.
2524.
2525.
2526.
2527.
2528.
2529.
2530.
2531.
2532.
2533.
2534.
2535.
2536.
2537.
2538.
2539.
2540.
2541.
2007;25:371-379
Tolar J, O'Shaughnessy MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Riddle M, McIvor RS, Yant SR, Kay
MA, Krause D, Verfaillie CM, Blazar BR. Host factors that impact the biodistribution and persistence of
multipotent adult progenitor cells. Blood. 2006;107:4182-4188
Tolar J, Osborn M, Bell S, McElmurry R, Xia L, Riddle M, Panoskaltsis-Mortari A, Jiang Y, McIvor RS, Contag
CH. Real-time in vivo imaging of stem cells following transgenesis by transposition. Molecular Therapy.
2005;12:42-48
Tolar J, Osborn M, Bell S, Xia L, Riddle M, Panoskaltsis-Mortari A, McIvor S, Stephen YR, Kay MA, Contag CH,
Verfaillie CM, Blazar BR. Transgenesis of multipotent adult progenitor cells (mapc) with sleeping beauty
transposons to determine mapc homing and persistence in real-time in vivo. Blood. 2004;104:577A-578A
Tolar J, Wang X, Braunlin E, McElmurry RT, Nakamura Y, Bell S, Xia L, Zhang J, Hu Q, Panoskaltsis-Mortari A,
Zhang J, Blazar BR. The host immune response is essential for the beneficial effect of adult stem cells after
myocardial ischemia. Exp Hematol. 2007;35:682-690
Tong Z, Kunnumakkara AB, Wang H, Matsuo Y, Diagaradjane P, Harikumar KB, Ramachandran V, Sung B,
Chakraborty A, Bresalier RS, Logsdon C, Aggarwal BB, Krishnan S, Guha S. Neutrophil gelatinase-associated
lipocalin: A novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res.
2008;68:6100-6108
Torres-Arzayus M, Yuan J, DellaGatta J, Lane H, Kung A, Brown M. Targeting the aib1 oncogene through
mammalian target of rapamycin inhibition in the mammary gland. Cancer Res. 2006;66:11381
Toyoshima M, Tanaka Y, Matumoto M, Yamazaki M, Nagase S, Sugamura K, Yaegashi N. Generation of a
syngeneic mouse model to study the intraperitoneal dissemination of ovarian cancer with in vivo luciferase
imaging. Luminescence. 2009
Tr ek J, Berschl K, Trülzsch K. In vivo analysis of yersinia enterocolitica infection using luxcdabe. FEMS
Microbiology Letters. 2010;307:201-206
Trageser D, Iacobucci I, Nahar R, Duy C, von Levetzow G, Klemm L, Park E, Schuh W, Gruber T, Herzog S, Kim Y,
Hofmann WK, Li A, Storlazzi CT, Jäck HM, Groffen J, Martinelli G, Heisterkamp N, Jumaa H, Müschen M. Pre–b
cell receptor–mediated cell cycle arrest in philadelphia chromosome–positive acute lymphoblastic leukemia
requires ikaros function. Journal of Experimental Medicine. 2009;206:1739-1753
Trang P, Wiggins JF, Daige CL, Cho C, Omotola M, Brown D, Weidhaas JB, Bader AG, Slack FJ. Systemic delivery
of tumor suppressor microrna mimics using a neutral lipid emulsion inhibits lung tumors in mice. Molecular
therapy : the journal of the American Society of Gene Therapy. 2011;19:1116-1122
Traykova-Brauch M, Schonig K, Greiner O, Miloud T, Jauch A, Bode M, Felsher DW, Glick AB, Kwiatkowski DJ,
Bujard H, Horst J, von Knebel Doeberitz M, Niggli FK, Kriz W, Grone HJ, Koesters R. An efficient and versatile
system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med.
2008;14:979-984
Trembley JH, Wang G, Unger G, Slaton J, Ahmed K. Protein kinase ck2 in health and disease: Ck2: A key player in
cancer biology. Cell Mol Life Sci. 2009;66:1858-1867
Troy T, Jekic-McMullen D, Sambucetti L, Rice B. Quantitative comparison of the sensitivity of detection of
fluorescent and bioluminescent reporters in animal models. Molecular imaging : official journal of the Society
for Molecular Imaging. 2004;3:9-23
Truksa J, Lee P, Peng H, Flanagan J, Beutler E. The distal location of the iron responsive region of the hepcidin
promoter. Blood. 2007;110:3436-3437
Tsai S, Leukel HC, Morita C, Heikens MJ, Cao TM. Functional characterization ofa continuous natural miter cell
line, kil, in vitro and in adoptive immunotherapy. Blood. 2006;108:1055A
Tsen SWD, Wu CY, Meneshian A, Pai SI, Hung CF, Wu TC. Femtosecond laser treatment enhances DNA
transfection efficiency in vivo. Journal of Biomedical Science. 2009;16:36
Tseng C, Trimble C, Zeng Q, Monie A, Alvarez RD, Huh WK, Hoory T, Wang MC, Hung CF, Wu TC. Low-dose
radiation enhances therapeutic hpv DNA vaccination in tumor-bearing hosts. Cancer Immunology,
Immunotherapy. 2009;58:737-748
Tseng CL, Wang TW, Dong GC, Yueh-Hsiu Wu S, Young TH, Shieh MJ, Lou PJ, Lin FH. Development of gelatin
nanoparticles with biotinylated egf conjugation for lung cancer targeting. Biomaterials. 2007;28:3996-4005
Tseng CL, Wu SY, Wang WH, Peng CL, Lin FH, Lin CC, Young TH, Shieh MJ. Targeting efficiency and
biodistribution of biotinylated-egf-conjugated gelatin nanoparticles administered via aerosol delivery in nude
mice with lung cancer. Biomaterials. 2008;29:3014-3022
Tseng CW, Hung CF, Alvarez RD, Trimble C, Huh WK, Kim D, Chuang CM, Lin CT, Tsai YC, He L, Monie A, Wu
TC. Pretreatment with cisplatin enhances e7-specific cd8+ t-cell-mediated antitumor immunity induced by DNA
vaccination. Clin Cancer Res. 2008;14:3185-3192
Tseng CW, Monie A, Wu CY, Huang B, Wang MC, Hung CF, Wu TC. Treatment with proteasome inhibitor
bortezomib enhances antigen-specific cd8+ t cell-mediated antitumor immunity induced by DNA vaccination.
Journal of Molecular Medicine. 2008;86:899-908
Tseng CW, Trimble C, Monie A, Alvarez RD, Huh WK, Buchsbaum DJ, Straughn JM, Wang MC, Yagita H, Hung
CF, Wu TC. Combination of treatment with death receptor 5-specific antibody with therapeutic hpv DNA
vaccination generates enhanced therapeutic antitumor effects. Vaccine. 2008;26:4314-4319
Tseng J, Zanzonico P, Levin B, Finn R, Larson S, Meruelo D. Tumor-specific in vivo transfection with hsv-1
2542.
2543.
2544.
2545.
2546.
2547.
2548.
2549.
2550.
2551.
2552.
2553.
2554.
2555.
2556.
2557.
2558.
2559.
2560.
2561.
2562.
2563.
2564.
2565.
thymidine kinase gene using a sindbis viral vector as a basis for prodrug ganciclovir activation and pet. Journal
of Nuclear Medicine. 2006;47:1136
Tseng JC, Hurtado A, Yee H, Levin B, Boivin C, Benet M, Blank SV, Pellicer A, Meruelo D. Using sindbis viral
vectors for specific detection and suppression of advanced ovarian cancer in animal models. Cancer Res.
2004;64:6684-6692
Tseng JC, Levin B, Hurtado A, Yee H, Perez de Castro I, Jimenez M, Shamamian P, Jin R, Novick RP, Pellicer A,
Meruelo D. Systemic tumor targeting and killing by sindbis viral vectors. Nat Biotechnol. 2004;22:70-77
Tseng JC, Zheng Y, Yee H, Levy DE, Meruelo D. Restricted tissue tropism and acquired resistance to sindbis viral
vector expression in the absence of innate and adaptive immunity. Gene Ther. 2007;14:1166-1174
Tsui LV, Kelly M, Zayek N, Rojas V, Ho K, Ge Y, Moskalenko M, Mondesire J, Davis J, Roey MV, Dull T,
McArthur JG. Production of human clotting factor ix without toxicity in mice after vascular delivery of a
lentiviral vector. Nat Biotechnol. 2002;20:53-57
Tsuji O, Miura K, Okada Y, Fujiyoshi K, Mukaino M, Nagoshi N, Kitamura K, Kumagai G, Nishino M, Tomisato S,
Higashi H, Nagai T, Katoh H, Kohda K, Matsuzaki Y, Yuzaki M, Ikeda E, Toyama Y, Nakamura M, Yamanaka S,
Okano H. Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord
injury. Proc Natl Acad Sci U S A. 2010;107:12704-12709
Tsunooka N, Hirayama S, Medin JA, Liles WC, Keshavjee S, Waddell TK. A novel tissue-engineered approach to
problems of the postpneumonectomy space. The Annals of thoracic surgery. 2011;91:880-886
Tsutsumi S, Scroggins B, Koga F, Lee MJ, Trepel J, Felts S, Carreras C, Neckers L. A small molecule cellimpermeant hsp90 antagonist inhibits tumor cell motility and invasion. Oncogene. 2008;27:2478-2487
Tu Q, Zhang J, Dong LQ, Saunders E, Luo E, Tang J, Chen J. Adiponectin inhibits osteoclastogenesis and bone
res o rp t i o n v i a ap p l 1 -med i at ed s u p p res s i o n o f ak t 1 . Th e Jo u r n a l o f b i o l o g i ca l ch emi s t r y.
2011;286:12542-12553
Tu Q, Zhang J, Fix A, Brewer E, Li YP, Zhang Z, Chen J. Targeted overexpression of bsp in osteoclasts promotes
bone metastasis of breast cancer cells. Journal of Cellular Physiology. 2009;218:135-145
Tuomanen E. Attachment and invasion of the respiratory tract. The pneumococcus. 2004:221
Turk AN, Byer SJ, Zinn KR, Carroll SL. Orthotopic xenografting of human luciferase-tagged malignant peripheral
nerve sheath tumor cells for in vivo testing of candidate therapeutic agents. J Vis Exp. 2011:e2558
Tysome JR, Briat A, Alusi G, Cao F, Gao D, Yu J, Wang P, Yang S, Dong Z, Wang S, Deng L, Francis J, Timiryasova
T, Fodor I, Lemoine NR, Wang Y. Lister strain of vaccinia virus armed with endostatin-angiostatin fusion gene as
a novel therapeutic agent for human pancreatic cancer. Gene Ther. 2009
Tzuman YC, Sapoznik S, Granot D, Nevo N, Neeman M. Peritoneal adhesion and angiogenesis in ovarian
carcinoma are inversely regulated by hyaluronan: The role of gonadotropins. Neoplasia. 2010;12:51-60
Uchibori R, Okada T, Ito T, Urabe M, Mizukami H, Kume A, Ozawa K. Retroviral vector-producing mesenchymal
stem cells for targeted suicide cancer gene therapy. J Gene Med. 2009;11:373-381
Uchida S, Itaka K, Chen Q, Osada K, Miyata K, Ishii T, Harada-Shiba M, Kataoka K. Combination of chondroitin
sulfate and polyplex micelles from poly(ethylene glycol)-poly{n'-[n-(2-aminoethyl)-2-aminoethyl]aspartamide}
block copolymer for prolonged in vivo gene transfection with reduced toxicity. Journal of controlled release :
official journal of the Controlled Release Society. 2011
Uddin MJ, Crews BC, Blobaum AL, Kingsley PJ, Gorden DL, McIntyre JO, Matrisian LM, Subbaramaiah K,
Dannenberg AJ, Piston DW, Marnett LJ. Selective visualization of cyclooxygenase-2 in inflammation and cancer
by targeted fluorescent imaging agents. Cancer Res. 2010;70:3618-3627
Ueda J, Li Y, Goh M, Maruyama Y, Sugar J, Yue B. Reporter gene construct containing 1.4 kb 1 proteinase
inhibitor promoter confers expression in the cornea of transgenic mice. The Anatomical Record. 2002;266:5-9
Uhrbom L, Nerio E, Holland EC. Dissecting tumor maintenance requirements using bioluminescence imaging of
cell proliferation in a mouse glioma model. Nat Med. 2004;10:1257-1260
Uliczka F, Pisano F, Kochut A, Opitz W, Herbst K, Stolz T, Dersch P. Monitoring of gene expression in bacteria
during infections using an adaptable set of bioluminescent, fluorescent and colorigenic fusion vectors. PloS one.
2011;6:e20425
Uluçkan Ö, Eagleton MC, Floyd DH, Morgan EA, Hirbe AC, Kramer M, Dowland N, Prior JL, Piwnica-Worms D,
Jeong SS, Chen R, Weilbaecher K. Apt102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in
mice. Journal of Cellular Biochemistry. 2008;104:1311-1323
Unciti-Broceta A, Moggio L, Dhaliwal K, Pidgeon L, Finlayson K, Haslett C, Bradley M. Safe and efficient in vitro
and in vivo gene delivery: Tripodal cationic lipids with programmed biodegradability. Journal of Materials
Chemistry. 2011;21:2154-2158
Ushiki T, Kizaka-Kondoh S, Ashihara E, Tanaka S, Masuko M, Hirai H, Kimura S, Aizawa Y, Maekawa T, Hiraoka
M. Noninvasive tracking of donor cell homing by near-infrared fluorescence imaging shortly after bone marrow
transplantation. PLoS One. 2010;5
Vallera DA, Chen H, Sicheneder AR, Panoskaltsis-Mortari A, Taras EP. Genetic alteration of a bispecific ligand
directed toxin targeting human cd19 and cd22 receptors resulting in improved efficacy against systemic b cell
malignancy. Leukemia Research. 2009;33:1233-1242
Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Zaborin A, Drabik K, Katdare M, Mauceri
H, Weichselbaum R, Firestone MA, Lee KY, Chang EB, Matthews J, Alverdy JC. Oral peg 15-20 protects the
intestine against radiation: Role of lipid rafts. Am J Physiol Gastrointest Liver Physiol. 2009;297:G1041-1052
2566.
2567.
2568.
2569.
2570.
2571.
2572.
2573.
2574.
2575.
2576.
2577.
2578.
2579.
2580.
2581.
2582.
2583.
2584.
2585.
2586.
2587.
2588.
van Beek ER, Lowik CW, van Wijngaarden J, Ebetino FH, Papapoulos SE. Synergistic effect of bisphosphonate
and docetaxel on the growth of bone metastasis in an animal model of established metastatic bone disease.
Breast Cancer Res Treat. 2009;118:307-313
van den Berg J, Hennink W, Storm G, Beijnen J, Haanen J, Schumacher T, Nuijen B. Lipopolysaccharide
contamination in intradermal DNA vaccination: Toxicimpurity or adjuvant? FORMULATION AND DELIVERY OF
DERMAL DNA VACCINES, Chapter 4. 2009:121
van den Berg JH, Nuijen B, Beijnen JH, Vincent A, van Tinteren H, Kluge J, Woerdeman LA, Hennink WE, Storm G,
Schumacher TN, Haanen JB. Optimization of intradermal vaccination by DNA tattooing in human skin. Human
Gene Therapy. 2009;20:181-189
van den Berg JH, Oosterhuis K, Hennink WE, Storm G, van der Aa LJ, Engbersen JF, Haanen JB, Beijnen JH,
Schumacher TN, Nuijen B. Shielding the cationic charge of nanoparticle-formulated dermal DNA vaccines is
essential for antigen expression and immunogenicity. J Control Release. 2010;141:234-240
van der Bogt KE, Schrepfer S, Yu J, Sheikh AY, Hoyt G, Govaert JA, Velotta JB, Contag CH, Robbins RC, Wu JC.
Comparison of transplantation of adipose tissue- and bone marrow- derived mesenchymal stem cells in the
infarcted heart. Transplantation. 2009;87:642-652
van der Bogt KE, Sheikh AY, Schrepfer S, Hoyt G, Cao F, Ransohoff KJ, Swijnenburg RJ, Pearl J, Lee A, Fischbein
M, Contag CH, Robbins RC, Wu JC. Comparison of different adult stem cell types for treatment of myocardial
ischemia. Circulation. 2008;118:S121-129
van der Poel HG, Buckle T, Brouwer OR, Valdes Olmos RA, van Leeuwen FW. Intraoperative laparoscopic
fluorescence guidance to the sentinel lymph node in prostate cancer patients: Clinical proof of concept of an
integrated functional imaging approach using a multimodal tracer. European urology. 2011
van Leeuwen AC, Buckle T, Bendle G, Vermeeren L, Valdes Olmos R, van de Poel HG, van Leeuwen FW. Tracercocktail injections for combined pre- and intraoperative multimodal imaging of lymph nodes in a spontaneous
mouse prostate tumor model. Journal of biomedical optics. 2011;16:016004
van Pijkeren JP, Morrissey D, Monk IR, Cronin M, Rajendran S, O'Sullivan GC, Gahan CG, Tangney M. A novel
listeria monocytogenes-based DNA delivery system for cancer gene therapy. Hum Gene Ther. 2010;21:405-416
VanHandel M, Alizadeh D, Zhang L, Kateb B, Bronikowski M, Manohara H, Badie B. Selective uptake of multiwalled carbon nanotubes by tumor macrophages in a murine glioma model. J Neuroimmunol. 2009;208:3-9
Varol C, Landsman L, Fogg DK, Greenshtein L, Gildor B, Margalit R, Kalchenko V, Geissmann F, Jung S.
Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. Journal of Experimental
Medicine. 2007;204:171-180
Vassileva V, Moriyama EH, De Souza R, Grant J, Allen CJ, Wilson BC, Piquette-Miller M. Efficacy assessment of
sustained intraperitoneal paclitaxel therapy in a murine model of ovarian cancer using bioluminescent imaging.
British Journal of Cancer. 2008;99:2037-2043
Veiseh M, Gabikian P, Bahrami SB, Veiseh O, Zhang M, Hackman RC, Ravanpay AC, Stroud MR, Kusuma Y,
Hansen SJ, Kwok D, Munoz NM, Sze RW, Grady WM, Greenberg NM, Ellenbogen RG, Olson JM. Tumor paint: A
chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci. Cancer Res. 2007;67:6882-6888
Veiseh O, Sun C, Fang C, Bhattarai N, Gunn J, Kievit F, Du K, Pullar B, Lee D, Ellenbogen RG, Olson J, Zhang M.
Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain
barrier. Cancer Res. 2009;69:6200-6207
Venisnik K, Olafsen T, Gambhir S, Wu A. Fusion of gaussia luciferase to an engineered anti-carcinoembryonic
antigen (cea) antibody for in vivo optical imaging. Molecular Imaging and Biology. 2007;9:267-277
Venisnik KM, Olafsen T, Loening AM, Iyer M, Gambhir SS, Wu AM. Bifunctional antibody-renilla luciferase
fusion protein for in vivo optical detection of tumors. Protein Engineering, Design and Selection.
2006;19:453-460
Venkataraman T, Valdes M, Elsby R, Kakuta S, Caceres G, Saijo S, Iwakura Y, Barber G. Loss of dexd/h box rna
helicase lgp2 manifests disparate antiviral responses. The Journal of Immunology. 2007;178:6444
Vera J, Savoldo B, Vigouroux S, Biagi E, Pule M, Rossig C, Wu J, Heslop HE, Rooney CM, Brenner MK, Dotti G. T
lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature b
lymphocyte-derived malignant cells. Blood. 2006;108:3890-3897
Vera JF, Hoyos V, Savoldo B, Quintarelli C, Giordano Attianese GM, Leen AM, Liu H, Foster AE, Heslop HE,
Rooney CM, Brenner MK, Dotti G. Genetic manipulation of tumor-specific cytotoxic t lymphocytes to restore
responsiveness to il-7. Mol Ther. 2009;17:880-888
Vera M, Sobrevals L, Zaratiegui M, Martinez L, Palencia B, Rodriguez CM, Prieto J, Fortes P. Liver transduction
with a simian virus 40 vector encoding insulin-like growth factor i reduces hepatic damage and the development
of liver cirrhosis. Gene Ther. 2007;14:203-210
Verbrugge I, Wissink EH, Rooswinkel RW, Jongsma J, Beltraminelli N, Dupuis M, Borst J, Verheij M. Combining
radiotherapy with apo010 in cancer treatment. Clin Cancer Res. 2009;15:2031-2038
Verheul HM, Hammers H, van Erp K, Wei Y, Sanni T, Salumbides B, Qian DZ, Yancopoulos GD, Pili R. Vascular
endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic
murine renal cell cancer model. Clin Cancer Res. 2007;13:4201-4208
Verheul HM, Salumbides B, Van Erp K, Hammers H, Qian DZ, Sanni T, Atadja P, Pili R. Combination strategy
targeting the hypoxia inducible factor-1 alpha with mammalian target of rapamycin and histone deacetylase
2589.
2590.
2591.
2592.
2593.
2594.
2595.
2596.
2597.
2598.
2599.
2600.
2601.
2602.
2603.
2604.
2605.
2606.
2607.
2608.
2609.
2610.
2611.
2612.
2613.
inhibitors. Clin Cancer Res. 2008;14:3589-3597
Verma A, Guha S, Diagaradjane P, Kunnumakkara AB, Sanguino AM, Lopez-Berestein G, Sood AK, Aggarwal BB,
Krishnan S, Gelovani JG, Mehta K. Therapeutic significance of elevated tissue transglutaminase expression in
pancreatic cancer. Clin Cancer Res. 2008;14:2476-2483
Verneris MR, Arshi A, Edinger M, Kornacker M, Natkunam Y, Karami M, Cao Y-a, Marina N, Contag CH, Negrin
RS. Low levels of her2/neu expressed by ewing's family tumor cell lines can redirect cytokine-induced killer
cells. Clin Cancer Res. 2005;11:4561-4570
Verra NC, Jorritsma A, Weijer K, Ruizendaal JJ, Voordouw A, Weder P, Hooijberg E, Schumacher TN, Haanen JB,
Spits H, Luiten RM. Human telomerase reverse transcriptase-transduced human cytotoxic t cells suppress the
growth of human melanoma in immunodeficient mice. Cancer Res. 2004;64:2153-2161
Versteeg HH, Schaffner F, Kerver M, Petersen HH, Ahamed J, Felding-Habermann B, Takada Y, Mueller BM, Ruf W.
Inhibition of tissue factor signaling suppresses tumor growth. Blood. 2008;111:190-199
Vi JGT, Cheuk AT, Tsang PS, Chung JY, Song YK, Desai K, Yu Y, Chen QR, Shah K, Youngblood V, Fang J, Kim
SY, Yeung C, Helman LJ, Mendoza A, Ngo V, Staudt LM, Wei JS, Khanna C, Catchpoole D, Qualman SJ, Hewitt
SM, Merlino G, Chanock SJ, Khan J. Identification of fgfr4-activating mutations in human rhabdomyosarcomas
that promote metastasis in xenotransplanted models. Journal of Clinical Investigation. 2009;119:3395-3407
Vigil A, Park MS, Martinez O, Chua MA, Xiao S, Cros JF, Martinez-Sobrido L, Woo SL, Garcia-Sastre A. Use of
reverse genetics to enhance the oncolytic properties of newcastle disease virus. Cancer Res. 2007;67:8285-8292
Vij N, Min T, Marasigan R, Belcher CN, Mazur S, Ding H, Yong KT, Roy I. Development of pegylated plga
nanoparticle for controlled and sustained drug delivery in cystic fibrosis. J Nanobiotechnology. 2010;8:22
Vijayakumar S, Liu G, Rus IA, Yao S, Chen Y, Akiri G, Grumolato L, Aaronson SA. High-frequency canonical wnt
activation in multiple sarcoma subtypes drives proliferation through a tcf/beta-catenin target gene, cdc25a.
Cancer cell. 2011;19:601-612
Vikis HG, Jackson EN, Krupnick AS, Franklin A, Gelman AE, Chen Q, Piwnica-Worms D, You M. Strain-specific
susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice. Cancer Res. 2010;70:4859-4867
Villalobos V, Naik S, Piwnica-Worms D. Current state of imaging protein-protein interactions in vivo with
genetically encoded reporters. Annu Rev Biomed Eng. 2007
Villalobos V, Naik S, Piwnica-Worms D. Detection of protein-protein interactions in live cells and animals with
split firefly luciferase protein fragment complementation. Methods Mol Biol. 2008;439:339-352
Viola RJ, Provenzale JM, Li F, Li CY, Yuan H, Tashjian J, Dewhirst MW. In vivo bioluminescence imaging
monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy. AJR
Am J Roentgenol. 2008;191:1779-1784
Virk M, Conduah A, Park S, Liu N, Sugiyama O, Cuomo A, Kang C, Lieberman J. Influence of short-term
adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the
quality of bone repair in a rat femoral defect model. Bone. 2008;42:921-931
Virostko J, Powers AC, Jansen ED. Validation of luminescent source reconstruction using single-view spectrally
resolved bioluminescence images. Appl Opt. 2007;46:2540-2547
Virostko J, Radhika A, Poffenberger G, Chen Z, Brissova M, Gilchrist J, Coleman B, Gannon M, Jansen ED, Powers
AC. Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet
transplantation. Mol Imaging Biol. 2009
Virostko JM, Powers AC, Jansen ED. Validation of luminescent source reconstruction using spectrally resolved
bioluminescence images. In: Raghavachari R, Liang R, eds. Design and quality for biomedical technologies.
Bellingham: Spie-Int Soc Optical Engineering; 2008:U104-U108.
Vishwanath RP, Brown CE, Wagner JR, Meechoovet HB, Naranjo A, Wright CL, Olivares S, Qian D, Cooper LJ,
Jensen MC. A quantitative high-throughput chemotaxis assay using bioluminescent reporter cells. J Immunol
Methods. 2005;302:78-89
Viviani VR, Prado RA, Arnoldi FC, Abdalla FC. An ancestral luciferase in the malpighi tubules of a nonbioluminescent beetle! Photochem Photobiol Sci. 2009;8:57-61
Vodnala SK, Ferella M, Lunden-Miguel H, Betha E, van Reet N, Amin DN, Oberg B, Andersson B, Kristensson K,
Wigzell H, Rottenberg ME. Preclinical assessment of the treatment of second-stage african trypanosomiasis with
cordycepin and deoxycoformycin. PLoS Negl Trop Dis. 2009;3:e495
von Degenfeld G, Wehrman TS, Hammer MM, Blau HM. A universal technology for monitoring g-protein-coupled
receptor activation in vitro and noninvasively in live animals. Faseb J. 2007;21:3819-3826
von Kockritz-Blickwede M, Goldmann O, Thulin P, Heinemann K, Norrby-Teglund A, Rohde M, Medina E.
Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation. Blood.
2008;111:3070-3080
von Kockritz-Blickwede M, Rohde M, Oehmcke S, Miller LS, Cheung AL, Herwald H, Foster S, Medina E.
Immunological mechanisms underlying the genetic predisposition to severe staphylococcus aureus infection in
the mouse model. Am J Pathol. 2008;173:1657-1668
von Maltzahn G, Park JH, Lin KY, Singh N, Schwoppe C, Mesters R, Berdel WE, Ruoslahti E, Sailor MJ, Bhatia SN.
Nanoparticles that communicate in vivo to amplify tumour targeting. Nature materials. 2011;10:545-552
Vooijs M, Jonkers J, Lyons S, Berns A. Noninvasive imaging of spontaneous retinoblastoma pathway-dependent
tumors in mice. Cancer Res. 2002;62:1862-1867
Vuong C, Kocianova S, Yu J, Kadurugamuwa JL, Otto M. Development of real-time in vivo imaging of device-
2614.
2615.
2616.
2617.
2618.
2619.
2620.
2621.
2622.
2623.
2624.
2625.
2626.
2627.
2628.
2629.
2630.
2631.
2632.
2633.
2634.
2635.
2636.
2637.
related staphylococcus epidermidis infection in mice and influence of animal immune status on susceptibility to
infection. Journal of Infectious Diseases. 2008;198:258-261
Vyas A, Kim SK, Giacomini N, Boothroyd JC, Sapolsky RM. Behavioral changes induced by toxoplasma
infection of rodents are highly specific to aversion of cat odors. Proceedings of the National Academy of
Sciences of the United States of America. 2007;104:6442-6447
Vykhovanets EV, Shukla S, Maclennan GT, Resnick MI, Carlsen H, Blomhoff R, Gupta S. Molecular imaging of
nf-kappab in prostate tissue after systemic administration of il-1beta. Prostate. 2008;68:34-41
Wada M, Watanabe S, Chung UI, Higo N, Taniguchi T, Kitazawa S. Noninvasive bioluminescence imaging of c-fos
expression in the mouse barrel cortex. Behav Brain Res. 2009
Waddington SN, Parker AL, Havenga M, Nicklin SA, Buckley SMK, McVey JH, Baker AH. Targeting of adenovirus
serotype 5 (ad5) and 5/47 pseudotyped vectors in vivo: Fundamental involvement of coagulation factors and
redundancy of car binding by ad5▿. J Virol. 2007;81:9568-9571
Wajapeyee N, Kapoor V, Mahalingam M, Green MR. Efficacy of igfbp7 for treatment of metastatic melanoma and
other cancers in mouse models and human cell lines. Mol Cancer Ther. 2009;8:3009-3014
Waldman E, Lu SX, Hubbard VM, Kochman AA, Eng JM, Terwey TH, Muriglan SJ, Kim TD, Heller G, Murphy GF,
Liu C, Alpdogan O, van den Brink MRM. Absence of β7 integrin results in less graft-versus-host disease because
of decreased homing of alloreactive t cells to intestine. Blood. 2006;107:1703-1711
Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, Becker C, Weigmann B, Vieth M, Rose-John S,
Neurath MF. Vegf receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp
Med. 2010;207:2855-2868
Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ.
Activation of apoptosis in vivo by a hydrocarbon-stapled bh3 helix. Science. 2004;305:1466-1470
Wallace K, Cowie DE, Konstantinou DK, Hill SJ, Tjelle TE, Axon A, Koruth M, White SA, Carlsen H, Mann DA,
Wright MC. The pxr is a drug target for chronic inflammatory liver disease☆. Journal of Steroid Biochemistry
and Molecular Biology. 2010;120:137-148
Wallis de Vries BMJ-LH, Gooitzen M. van Dam, René A. Tio, Johannes S. de Jong, Riemer H.J.A. Slart, and Clark J.
Zeebregts, N M. Multispectral near-infrared fluorescence molecular imaging of matrix metalloproteinases in a
human carotid plaque using a matrix-degrading metalloproteinase–sensitive activatable fluorescent probe
Circulation. 2009;119:534-536
Walls ZF, Puttaraju M, Temple GF, Gambhir SS. A generalizable strategy for imaging pre-mrna levels in living
subjects using spliceosome-mediated rna trans-splicing. J Nucl Med. 2008;49:1146-1154
Walsh M, Tangney M, O'Neill M, Larkin J, Soden D, McKenna S, Darcy R, O'sullivan G, O'Driscoll C. Evaluation
of cellular uptake and gene transfer efficiency of pegylated poly-l-lysine compacted DNA: Implications for
cancer gene therapy. Mol. Pharm. 2006;3:644-653
Walton CB, Anderson CD, Boulay R, Shohet RV. Introduction to the ultrasound targeted microbubble
destruction technique. J Vis Exp. 2011:e2963
Wan X, Kim SY, Guenther LM, Mendoza A, Briggs J, Yeung C, Currier D, Zhang H, Mackall C, Li WJ, Tuan RS,
Deyrup AT, Khanna C, Helman L. Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin.
Oncogene. 2009;28:3401-3411
Wan YY, Flavell RA. Regulatory t-cell functions are subverted and converted owing to attenuated foxp3
expression. Nature. 2007
Wang C, Li F, Yang Y, Guo H, Wu C, Wang S. Recombinant baculovirus containing the diphtheria toxin a gene for
malignant glioma therapy. Cancer Res. 2006;66:5798
Wang C, Wu C, Popescu DC, Zhu J, Macklin WB, Miller RH, Wang Y. Longitudinal near-infrared imaging of
myelination. J Neurosci. 2011;31:2382-2390
Wang D, Jensen R, Williams K, Pallavicini M. Differential protein expression in mcf7 breast cancer cells
transfected with erbb2, neomycin resistance and luciferase plus yellow fluorescent protein. Proteomics.
2004;4:2175-2183
Wang DB, Dayton RD, Henning PP, Cain CD, Zhao LR, Schrott LM, Orchard EA, Knight DS, Klein RL. Expansive
gene transfer in the rat cns rapidly produces amyotrophic lateral sclerosis relevant sequelae when tdp-43 is
overexpressed. Mol Ther. 2010;18:2064-2074
Wang F, Dennis JE, Awadallah A, Solchaga LA, Molter J, Kuang Y, Salem N, Lin Y, Tian H, Kolthammer JA, Kim Y,
Love ZB, Gerson SL, Lee Z. Transcriptional profiling of human mesenchymal stem cells transduced with reporter
genes for imaging. Physiol Genomics. 2009;37:23-34
Wang G, Shen H, Liu Y, Cong A, Cong W, Wang Y, Dubey P. Digital spectral separation methods and systems for
bioluminescence imaging. imaging. 2006;24:339-343
Wang H, Cao F, De A, Cao Y, Contag C, Gambhir SS, Wu JC, Chen X. Trafficking mesenchymal stem cell
engraftment and differentiation in tumor-bearing mice by bioluminescence imaging. Stem Cells.
2009;27:1548-1558
Wang H, Yan H, Fu A, Han M, Hallahan D, Han Z. Tip-1 translocation onto the cell plasma membrane is a
molecular biomarker of tumor response to ionizing radiation. PLoS One. 2010;5
Wang HW, Liou KT, Wang YH, Lu CK, Lin YL, Lee IJ, Huang ST, Tsai YH, Cheng YC, Lin HJ, Shen YC. Deciphering
the neuroprotective mechanisms of bu-yang huan-wu decoction by an integrative neurofunctional and genomic
approach in ischemic stroke mice. Journal of ethnopharmacology. 2011
2638.
2639.
2640.
2641.
2642.
2643.
2644.
2645.
2646.
2647.
2648.
2649.
2650.
2651.
2652.
2653.
2654.
2655.
2656.
2657.
2658.
2659.
2660.
2661.
Wang J, Barke RA, Charboneau R, Schwendener R, Roy S. Morphine induces defects in early response of alveolar
macrophages to streptococcus pneumoniae by modulating tlr9-nf-kappa b signaling. J Immunol.
2008;180:3594-3600
Wang J, Cai Y, Yu W, Ren C, Spencer DM, Ittmann M. Pleiotropic biological activities of alternatively spliced
tmprss2/erg fusion gene transcripts. Cancer Res. 2008;68:8516-8524
Wang J, Dai J, Jung Y, Wei C, Wang Y, Havens A, Hogg P, Keller E, Pienta K. A glycolytic mechanism regulating
an angiogenic switch in prostate cancer. Cancer Res. 2007;67:149
Wang J, Mahmud S, Nguyen J, Slungaard A. Thiocyanate-dependent induction of endothelial cell adhesion
molecule expression by phagocyte peroxidases: A novel hoscn-specific oxidant mechanism to amplify
inflammation. The Journal of Immunology. 2006;177:8714
Wang J, Ying G, Wang J, Jung Y, Lu J, Zhu J, Pienta KJ, Taichman RS. Characterization of phosphoglycerate
kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer progression.
Cancer Res. 2010;70:471-480
Wang K, Ruan J, Qian Q, Song H, Bao C, Zhang X, Kong Y, Zhang C, Hu G, Ni J, Cui D. Brcaa1 monoclonal
antibody conjugated fluorescent magnetic nanoparticles for in vivo targeted magnetofluorescent imaging of
gastric cancer. Journal of nanobiotechnology. 2011;9:23
Wang L, Fu Q, Dong Y, Zhou Y, Jia S, Du J, Zhao F, Wang Y, Wang X, Peng J, Yang S, Zhan L. Bioluminescence
imaging of hepatitis c virus ns3/4a serine protease activity in cells and living animals. Antiviral Res.
2010;87:50-56
Wang L, Heidt DG, Lee CJ, Yang H, Logsdon CD, Zhang L, Fearon ER, Ljungman M, Simeone DM. Oncogenic
function of atdc in pancreatic cancer through wnt pathway activation and β-catenin stabilization. Cancer Cell.
2009;15:207-219
Wang L, Martin DR, Baker HJ, Zinn KR, Kappes JC, Ding H, Gentry AS, Harper S, Snyder EY, Cox NR. Neural
progenitor cell transplantation and imaging in a large animal model. Neurosci Res. 2007;59:327-340
Wang N, Fallavollita L, Nguyen L, Burnier J, Rafei M, Galipeau J, Yakar S, Brodt P. Autologous bone marrow
stromal cells genetically engineered to secrete an igf-i receptor decoy prevent the growth of liver metastases. Mol
Ther. 2009;17:1241-1249
Wang Q, Contag CH, Ilves H, Johnston BH, Kaspar RL. Small hairpin rnas efficiently inhibit hepatitis c iresmediated gene expression in human tissue culture cells and a mouse model. Molecular Therapy. 2005;In Press,
Corrected Proof
Wang Q, Dolyle T, Cao Y, Contag C. A dual bioluminescent reporter transgenic mouse strain for noninvasive
bioluminescent imaging of cells that have undergone cre-mediated recombination-a useful model for
development research. Proceedings of the American Association for Cancer Research. 2006;2006:231
Wang Q, Ilves H, Chu P, Contag CH, Leake D, Johnston BH, Kaspar RL. Delivery and inhibition of reporter genes
by small interfering rnas in a mouse skin model. J Invest Dermatol. 2007
Wang Q, Luan W, Goz V, Burakoff SJ, Hiotis SP. Non-invasive in vivo imaging for liver tumour progression
using an orthotopic hepatocellular carcinoma model in immunocompetent mice. Liver international : official
journal of the International Association for the Study of the Liver. 2011
Wang S, El-Deiry W. Inducible silencing of killer/dr5 in vivo promotes bioluminescent colon tumor xenograft
growth and confers resistance to chemotherapeutic agent 5-fluorouracil. Cancer Res. 2004;64:6666
Wang S, El-Deiry WS. Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand
t h erap y . Pr o ceed i n g s o f t h e Na t i o n a l Aca d emy o f S ci en ces o f t h e Un i t ed S t a t es o f Amer i ca .
2003;100:15095-15100
Wang S, El-Deiry WS. P73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints.
Cancer Res. 2006;66:6982-6989
Wang S, Hu C, Zhu J. Transcriptional silencing of a novel htert reporter locus during in vitro differentiation of
mouse embryonic stem cells. Molecular Biology of the Cell. 2007;18:669-677
Wang T, Shah YM, Matsubara T, Zhen Y, Tanabe T, Nagano T, Fotso S, Krausz KW, Zabriskie TM, Idle JR, Gonzalez
FJ. Control of steroid 21-oic acid synthesis by peroxisome proliferator-activated receptor {alpha} and role of the
hypothalamic-pituitary-adrenal axis. J Biol Chem. 2010;285:7670-7685
Wang W, El-Deiry WS. Bioluminescent molecular imaging of endogenous and exogenous p53-mediated
transcription in vitro and in vivo using an hct116 human colon carcinoma xenograft model. Cancer Biol Ther.
2003;2:196-202
Wang W, Kim SH, El-Deiry WS. Small-molecule modulators of p53 family signaling and antitumor effects in p53deficient human colon tumor xenografts. Proceedings of the National Academy of Sciences of the United States
of America. 2006;103:11003-11008
Wang X, Jiang J, Warram J, Baumann G, Gan Y, Menon RK, Denson LA, Zinn KR, Frank SJ. Endotoxin-induced
proteolytic reduction in hepatic growth hormone receptor: A novel mechanism for gh insensitivity. Mol
Endocrinol. 2008
Wang X, Jiang J, Warram J, Baumann G, Gan Y, Menon RK, Denson LA, Zinn KR, Frank SJ. Endotoxin-induced
proteolytic reduction in hepatic growth hormone (gh) receptor: A novel mechanism for gh insensitivity.
Molecular Endocrinology. 2008;22:1427-1437
Wang X, Kohn M, Crooks G. Dynamic tracking of human hematopoietic stem cell engraftment using in vivo
bioluminescence imaging. Blood. 2003;102:3478-3482
2662.
2663.
2664.
2665.
2666.
2667.
2668.
2669.
2670.
2671.
2672.
2673.
2674.
2675.
2676.
2677.
2678.
2679.
2680.
2681.
2682.
2683.
2684.
2685.
2686.
2687.
Wang X, Rosol M, Ge S, Petersen D, Kohn DB, Nelson MD, Crooks GM. Vivo bioluminescence imaging reveals
the kinetics of human hematopoietic stem cell engraftment. Blood. 2003;102:939a
Wang X, Xu R, Wu X, Gillespie D, Jensen R, Lu Z. Targeted systemic delivery of a therapeutic sirna with a
multifunctional carrier controls tumor proliferation in mice. Molecular Pharmaceutics. 2009;6:738-746
Wang X, Xu W, Mohapatra S, Kong X, Li X, Lockey RF, Mohapatra SS. Prevention of airway inflammation with
topical cream containing imiquimod and small interfering rna for natriuretic peptide receptor. Genet Vaccines
Ther. 2008;6:7
Wang Y, Gangeswaran R, Zhao X, Wang P, Tysome J, Bhakta V, Yuan M, Chikkanna-Gowda C, Jiang G, Gao D, Cao
F, Francis J, Yu J, Liu K, Yang H, Zhang Y, Zang W, Chelala C, Dong Z, Lemoine N. Ceacam6 attenuates adenovirus
infection by antagonizing viral trafficking in cancer cells. Journal of Clinical Investigation.
2009;119:1604-1615
Wang Y, Hu J, Krol A, Li Y, Li C, Yuan F. Systemic dissemination of viral vectors during intratumoral injection.
Mol Cancer Ther. 2003;2:1233
Wang Y, Inoue H, Ravnskjaer K, Viste K, Miller N, Liu Y, Hedrick S, Vera L, Montminy M. Targeted disruption of
the creb coactivator crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A. 2010;107:3087-3092
Wang Y, Iyer M, Annala A, Wu L, Carey M, Gambhir S. Noninvasive indirect imaging of vascular endothelial
growth factor gene expression using bioluminescence imaging in living transgenic mice. Physiological
genomics. 2006;24:173
Wang Y, Iyer M, Annala AJ, Chappell S, Mauro V, Gambhir SS. Noninvasive monitoring of target gene expression
by imaging reporter gene expression in living animals using improved bicistronic vectors. J Nucl Med.
2005;46:667-674
Wang Y, Liu S, Li C, Yuan F. A novel method for viral gene delivery in solid tumors. Cancer Res. 2005;65:7541
WANG Y, MANDAL D, WANG S, HUGHES D, POLLOCK R, LEV D, KLEINERMAN E, HAYES-JORDAN A.
Inhibiting platelet-derived growth factor reduces ewing's sarcoma growth and metastasis in a novel orthotopic
human xenograft model. In Vivo. 2009;23:903
Wang Y, Saad M, Pakunlu RI, Khandare JJ, Garbuzenko OB, Vetcher AA, Soldatenkov VA, Pozharov VP, Minko T.
Nonviral nanoscale-based delivery of antisense oligonucleotides targeted to hypoxia-inducible factor 1 alpha
enhances the efficacy of chemotherapy in drug-resistant tumor. Clin Cancer Res. 2008;14:3607-3616
Wang Y, Sun Z, Peng J, Zhan L. Bioluminescent imaging of hepatocellular carcinoma in live mice. Biotechnol
Lett. 2007;29:1665-1670
Wang Y, Vera L, Fischer WH, Montminy M. The creb coactivator crtc2 links hepatic er stress and fasting
gluconeogenesis. Nature. 2009;460:534-537
Wang Y, Wang H, Li C, Yuan F. Effects of rate, volume, and dose of intratumoral infusion on virus dissemination
in local gene delivery. Mol Cancer Ther. 2006;5:362
Wang Y, Yang Z, Liu S, Kon T, Krol A, Li CY, Yuan F. Characterisation of systemic dissemination of
nonreplicating adenoviral vectors from tumours in local gene delivery. Br J Cancer. 2005;92:1414-1420
Wang Y, Yuan F. Delivery of viral vectors to tumor cells: Extracellular transport, systemic distribution, and
strategies for improvement. Annals of Biomedical Engineering. 2006;34:114-127
Wang Y, Zhang H, Chen Y, Sun Y, Yang F, Yu W, Liang J, Sun L, Yang X, Shi L, Li R, Li Y, Zhang Y, Li Q, Yi X,
Shang Y. Lsd1 is a subunit of the nurd complex and targets the metastasis programs in breast cancer. Cell.
2009;138:660-672
Wang Z, Maravelias C, Sibley E. Lactase gene promoter fragments mediate differential spatial and temporal
expression patterns in transgenic mice. DNA and Cell Biology. 2006;25:215-222
Wangensteen K, Wilber A, Zeng G, Frandsen J, McIvor R, Ekker S, Wang X. Luciferase as an in vivo reporter for
selective liver repopulation in adult fah-/-mice. Molecular Therapy. 2005;11:S411-S412
Wangensteen KJ, Wilber A, Keng VW, He Z, Matise I, Wangensteen L, Carson CM, Chen Y, Steer CJ, McIvor RS,
Largaespada DA, Wang X, Ekker SC. A facile method for somatic, lifelong manipulation of multiple genes in the
mouse liver. Hepatology. 2008;47:1714-1724
Warner KA, Miyazawa M, Cordeiro MM, Love WJ, Pinsky MS, Neiva KG, Spalding AC, Nor JE. Endothelial cells
enhance tumor cell invasion through a crosstalk mediated by cxc chemokine signaling. Neoplasia.
2008;10:131-139
Warner KA, Miyazawa M, Cordeiro MMR, Love WJ, Pinsky MS, Neiva KG, Spalding AC, Nör JE. Endothelial cells
enhance tumor cell invasion through a crosstalk mediated by cxc chemokine signaling1. Neoplasia.
2008;10:131-139
Wasungu L, Scarzello M, van Dam G, Molema G, Wagenaar A, Engberts J, Hoekstra D. Transfection mediated by
ph-sensitive sugar-based gemini surfactants; potential for in vivo gene therapy applications. Journal of
Molecular Medicine. 2006;84:774-784
Watanabe H, Ochiya T, Ueda S, Kominami Y, Gon R, Nishiki M, Hayashi M, Sasaki A, Shiraishi M, Kashimoto N.
Differentiation of a hepatic phenotype after heterotropic transplantation of heart, kidney, brain, and skin tissues
into liver in f344 rats. Biochemical and Biophysical Research Communications. 2007;354:841-845
Watanabe Y, Aoi A, Horie S, Tomita N, Mori S, Morikawa H, Matsumura Y, Vassaux G, Kodama T. Low-intensity
ultrasound and microbubbles enhance the antitumor effect of cisplatin. Cancer Sci. 2008;99:2525-2531
Watson D, Sleator RD, Casey PG, Hill C, Gahan CG. Specific osmolyte transporters mediate bile tolerance in
listeria monocytogenes. Infect Immun. 2009;77:4895-4904
2688.
2689.
2690.
2691.
2692.
2693.
2694.
2695.
2696.
2697.
2698.
2699.
2700.
2701.
2702.
2703.
2704.
2705.
2706.
2707.
2708.
2709.
2710.
2711.
2712.
Watson D, Sleator RD, Hill C, Gahan CG. Enhancing bile tolerance improves survival and persistence of
bifidobacterium and lactococcus in the murine gastrointestinal tract. BMC Microbiol. 2008;8:176
Watts JC, Giles K, Grillo SK, Lemus A, DeArmond SJ, Prusiner SB. Bioluminescence imaging of abeta deposition
in bigenic mouse models of alzheimer's disease. Proc Natl Acad Sci U S A. 2011;108:2528-2533
Wayman C, Baxter D, Hayward M, Burslem F. Oxytocin receptor gene deleted mice display disrupted sexual
function-increased ejaculatory latency in males, and abolishment of lordosis in females. Journal of Sexual
Medicine. 2009;6:55
Webb AB, Angelo N, Huettner JE, Herzog ED. Intrinsic, nondeterministic circadian rhythm generation in
identified mammalian neurons. Proceedings of the National Academy of Sciences of the United States of
America. 2009;106:16493-16498
Webber M, Tongers J, Renault M, Roncalli J, Losordo D, Stupp S. Development of bioactive peptide amphiphiles
for therapeutic cell delivery. Acta Biomaterialia. 2010;6:3-11
Wehrman T, von Degenfeld G, Krutzik P, Nolan G, Blau H. Luminescent imaging of -galactosidase activity in
living subjects using sequential reporter-enzyme luminescence. Nature Methods. 2006;3:295-301
Wei BR, Hoover SB, Ross MM, Zhou W, Meani F, Edwards JB, Spehalski EI, Risinger JI, Alvord WG, Quiñones
OA, Belluco C, Martella L, Campagnutta E, Ravaggi A, Dai RM, Goldsmith PK, Woolard KD, Pecorelli S, Liotta LA,
Petricoin EF, Simpson RM. Serum s100a6 concentration predicts peritoneal tumor burden in mice with epithelial
ovarian cancer and is associated with advanced stage in patients. PLoS One. 2009;4
Wei J, Jones J, Kang J, Card A, Krimm M, Hancock P, Pei Y, Ason B, Payson E, Dubinina N, Cancilla M, Stroh M,
Burchard J, Sachs AB, Hochman JH, Flanagan WM, Kuklin NA. Rna-induced silencing complex-bound small
interfering rna is a determinant of rna interference-mediated gene silencing in mice. Molecular pharmacology.
2011;79:953-963
Weidenfeld-Baranboim K, Bitton-Worms K, Aronheim A. Tre-dependent transcription activation by jdp2-chop10
association. Nucleic Acids Res. 2008;36:3608-3619
Weir LR, Schenck E, Meakin J, McClure F, Driver R, Walker S, Lynch AM. Biophotonic imaging in ho-1.Luc
transgenic mice: Real-time demonstration of gender-specific chloroform induced renal toxicity. Mutat Res.
2005;574:67-75
Weisberg E, Kung AL, Wright RD, Moreno D, Catley L, Ray A, Zawel L, Tran M, Cools J, Gilliland G, Mitsiades C,
McMillin DW, Jiang J, Hall-Meyers E, Griffin JD. Potentiation of antileukemic therapies by smac mimetic,
lbw242: Effects on mutant flt3-expressing cells. Mol Cancer Ther. 2007;6:1951-1961
Weisberg E, Manley PW, Breitenstein W, Bruggen J, Cowan-Jacob SW, Ray A, Huntly B, Fabbro D, Fendrich G,
Hall-Meyers E. Characterization of amn107, a selective inhibitor of native and mutant bcr-abl. Cancer Cell.
2005;7:129-141
Weiser-Evans MC, Wang XQ, Amin J, Van Putten V, Choudhary R, Winn RA, Scheinman R, Simpson P, Geraci
MW, Nemenoff RA. Depletion of cytosolic phospholipase a2 in bone marrow-derived macrophages protects
against lung cancer progression and metastasis. Cancer Res. 2009;69:1733-1738
Weisheng Z, Min C, West DB, Purchio AF. Visualizing drug efficacy in vivo. Mol Imaging. 2005;4:88-90
Weiss EM, Schmidt A, Vobis D, Garbi N, Lahl K, Mayer CT, Sparwasser T, Ludwig A, Suri-Payer E, Oberle N,
Krammer PH. Foxp3-mediated suppression of cd95l expression confers resistance to activation-induced cell
death in regulatory t cells. Journal of immunology. 2011;187:1684-1691
Weiss MS, Bernabé BP, Bellis AD, Broadbelt LJ, Jeruss JS, Shea L. Dynamic, large-scale profiling of transcription
factor activity from live cells in 3d culture. PLoS ONE. 2010
Weljie AM, Bondareva A, Zang P, Jirik FR. (1)h nmr metabolomics identification of markers of hypoxia-induced
metabolic shifts in a breast cancer model system. Journal of biomolecular NMR. 2011;49:185-193
Weller A, Leguisamo AC, Towns L, Ramboz S, Bagiella E, Hofer M, Hen R, Brunner D. Maternal effects in infant
and adult phenotypes of 5ht1a and 5ht1b receptor knockout mice. Developmental Psychobiology.
2003;42:194-205
Wen J, Feng Y, Bjorklund CC, Wang M, Orlowski RZ, Shi ZZ, Liao B, O'Hare J, Zu Y, Schally AV, Chang CC.
Luteinizing hormone-releasing hormone (lhrh)-i antagonist cetrorelix inhibits myeloma cell growth in vitro and
in vivo. Mol Cancer Ther. 2011;10:148-158
Wender PA, Goun EA, Jones LR, Pillow TH, Rothbard JB, Shinde R, Contag CH. Real-time analysis of uptake and
bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice. Proceedings of the
National Academy of Sciences of the United States of America. 2007;104:10340-10345
Wendt MK, Cooper AN, Dwinell MB. Epigenetic silencing of cxcl12 increases the metastatic potential of
mammary carcinoma cells. Oncogene. 2007
Wendt MK, Drury LJ, Vongsa RA, Dwinell MB. Constitutive cxcl12 expression induces anoikis in colorectal
carcinoma cells. Gastroenterology. 2008
Wendt MK, Drury LJ, Vongsa RA, Dwinell MB. Gastro-d-01631r1 constitutive cxcl12 expression induces anoikis
in colorectal carcinoma cells. Gastroenterology. 2008;135:508-517
Wendt MK, Schiemann WP. Therapeutic targeting of the focal adhesion complex prevents oncogenic tgf-β
signaling and metastasis. Breast Cancer Res. 2009;11:R68
Wendt MK, Smith JA, Schiemann WP. Transforming growth factor-beta-induced epithelial-mesenchymal
t ran s i t i o n faci l i t at es ep i d ermal g ro wt h fact o r-d ep en d en t b reas t can cer p ro g res s i o n . On co g en e.
2010;29:6485-6498
2713.
2714.
2715.
2716.
2717.
2718.
2719.
2720.
2721.
2722.
2723.
2724.
2725.
2726.
2727.
2728.
2729.
2730.
2731.
2732.
2733.
2734.
2735.
2736.
2737.
2738.
Werbeck JL, Thudi NK, Ostrowski MC, Rosol TJ. Gene expression in the metastatic microenvironment is
injection site dependent in the mmtv pymt breast cancer model. Proceedings of the American Association for
Cancer Research Annual Meeting. 2009;50:1204
Wessels JT, Busse AC, Mahrt J, Dullin C, Grabbe E, Mueller GA. In vivo imaging in experimental preclinical
tumor research--a review. Cytometry A. 2007;71:542-549
Westrich J, Yaeger P, He C, Stewart J, Chen R, Seleznik G, Larson S, Wentworth B, O'Callaghan M, Wadsworth S,
Akita G, Molnar G. Factors affecting residence time of mesenchymal stromal cells (msc) injected into the
myocardium. Cell Transplantation. 2010;19:937-948
White AG, Fu N, Leevy WM, Lee JJ, Blasco MA, Smith BD. Optical imaging of bacterial infection in living mice
using deep-red fluorescent squaraine rotaxane probes. Bioconjug Chem. 2010;21:1297-1304
White AP, Gibson DL, Grassl GA, Kay WW, Finlay BB, Vallance BA, Surette MG. Aggregation via the red, dry, and
rough morphotype is not a virulence adaptation in salmonella enterica serovar typhimurium. Infect Immun.
2008;76:1048-1058
White B, Wu L. Characterizing the effects of ezh2-overexpression in prostate cancer progression using in vivo
optical imaging. Proceedings of the American Association for Cancer Research. 2005;2005:1333
White B, Wu L. Regulated ezh2 over expression is necessary to produce a phenotype in prostate cancer.
Proceedings of the American Association for Cancer Research. 2006;2006:1210
Wiesner SM, Decker SA, Larson JD, Ericson K, Forster C, Gallardo JL, Long C, Demorest ZL, Zamora EA, Low WC,
SantaCruz K, Largaespada DA, Ohlfest JR. De novo induction of genetically engineered brain tumors in mice
using plasmid DNA. Cancer Res. 2009;69:431-439
Wilber A, Frandsen JL, Geurts JL, Largaespada DA, Hackett PB, McIvor RS. Rna as a source of transposase for
sleeping beauty-mediated gene insertion and expression in somatic cells and tissues. Molecular Therapy.
2006;13:625-630
Wilber A, Frandsen JL, Wangensteen KJ, Ekker SC, Wang X, McIvor RS. Dynamic gene expression after systemic
delivery of plasmid DNA as determined by in vivo bioluminescence imaging. Human Gene Therapy.
2005;16:1325-1332
Wilber A, Linehan JL, Tian X, Woll PS, Morris JK, Belur LR, McIvor RS, Kaufman DS. Efficient and stable
transgene expression in human embryonic stem cells using transposon-mediated gene transfer. Stem Cells.
2007;25:2919-2927
Wilber A, Wangensteen KJ, Chen Y, Zhuo L, Frandsen JL, Bell JB, Chen ZJ, Ekker SC, McIvor RS, Wang X.
Messenger rna as a source of transposase for sleeping beauty transposon-mediated correction of hereditary
tyrosinemia type i. Mol Ther. 2007
Wiles S, Crepin V, Childs G, Frankel G, Kerton A. Use of biophotonic imaging as a training aid for administration
of substances in laboratory rodents. Laboratory Animals. 2007;41:321
Wiles S, Dougan G, Frankel G. Emergence of a ‘hyperinfectious’ bacterial state after passage of citrobacter
rodentium through the host gastrointestinal tract. Cellular Microbiology. 2005;7:1163-1172
Wiles S, Pickard KM, Peng K, MacDonald TT, Frankel G. In vivo bioluminescence imaging of the murine
pathogen citrobacter rodentium. Infection and Immunity. 2006;74:5391-5396
Wiles S, Robertson BD, Frankel G, Kerton A. Bioluminescent monitoring of in vivo colonization and clearance
dynamics by light-emitting bacteria. Bioluminescence. 2009:137-153.
Wilkie S, Picco G, Foster J, Davies DM, Julien S, Cooper L, Arif S, Mather SJ, Taylor-Papadimitriou J, Burchell
JM, Maher J. Retargeting of human t cells to tumor-associated muc1: The evolution of a chimeric antigen
receptor. J Immunol. 2008;180:4901-4909
Williams R, Lee D, Elzey B, Anderson M, Hostager B, Lee J. Preclinical models of hpv+ and hpv- hnscc in mice:
An immune clearance of hpv+ hnscc. Head and Neck. 2009;31:911-918
Williamson M, Blank J, Bruzzese F, Cao Y, Daniels J, Dick L, Labutti J, Mazzola A, Patil A, Reimer C. Comparison
of biochemical and biological effects of ml858 (salinosporamide a) and bortezomib. Mol Cancer Ther.
2006;5:3052
Willis R. Bringing life to center stage. Modern drug discovery. 2004;7:28-32
Willmann JK, van Bruggen N, Dinkelborg LM, Gambhir SS. Molecular imaging in drug development. Nat Rev
Drug Discov. 2008;7:591-607
Wilmink GJ, Carter T, Davidson JM, Jansen ED. Laser thermal preconditioning enhances dermal wound repair art. No. 684200. In: Kollias N, Choi B, Zeng H, Malek RS, Wong BJF, Ilgner JFR, Gregory KW, Tearney GJ,
Hirschberg H, Madsen SJ, eds. Photonic therapeutics and diagnostics iv. Bellingham: Spie-Int Soc Optical
Engineering; 2008:84200-84200.
Wilmink GJ, Opalenik SR, Beckham JT, Davidson JM, Jansen ED. Assessing laser-tissue damage with
bioluminescent imaging. J Biomed Opt. 2006;11:041114
Wilmink GJ, Opalenik SR, Beckham JT, Mackanos MA, Nanney LB, Contag CH, Davidson JM, Jansen ED. In-vivo
optical imaging of hsp70 expression to assess collateral tissue damage associated with infrared laser ablation of
skin. J Biomed Opt. 2008;13:054066
Wilson AA, Murphy GJ, Hamakawa H, Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, Kotton
DN. Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar
macrophages. J Clin Invest. 2010;120:379-389
Wilson K, Yu J, Lee A, Wu JC. In vitro and in vivo bioluminescence reporter gene imaging of human embryonic
2739.
2740.
2741.
2742.
2743.
2744.
2745.
2746.
2747.
2748.
2749.
2750.
2751.
2752.
2753.
2754.
2755.
2756.
2757.
2758.
2759.
2760.
2761.
2762.
2763.
2764.
stem cells. J Vis Exp. 2008
Wilson KD, Huang M, Wu JC. Bioluminescence reporter gene imaging of human embryonic stem cell survival,
proliferation, and fate. Methods Mol Biol. 2009;574:87-103
Wingender G, Garbi N, Schumak B, Jüngerkes F, Endl E, von Bubnoff D, Steitz J, Striegler J, Moldenhauer G,
Tüting T. Systemic application of cpg rich DNA suppresses adaptive t cell immunity via induction of ido.
European Journal of Immunology. 2006;36:12-20
Winkeler A, Sena-Esteves M, Paulis LE, Li H, Waerzeggers Y, Ruckriem B, Himmelreich U, Klein M, Monfared P,
Rueger MA, Heneka M, Vollmar S, Hoehn M, Fraefel C, Graf R, Wienhard K, Heiss WD, Jacobs AH. Switching on
the lights for gene therapy. PLoS ONE. 2007;2:e528
Winkler DG, Sutherland MK, Geoghegan JC, Yu C, Hayes T, Skonier JE, Shpektor D, Jonas M, Kovacevich BR,
Staehling-Hampton K, Appleby M, Brunkow ME, Latham JA. Osteocyte control of bone formation via sclerostin,
a novel bmp antagonist. EMBO Journal. 2003;22:6267-6276
Winnard PT, Jr., Kluth JB, Raman V. Noninvasive optical tracking of red fluorescent protein-expressing cancer
cells in a model of metastatic breast cancer. Neoplasia. 2006;8:796-806
Winnard PT, Jr., Pathak AP, Dhara S, Cho SY, Raman V, Pomper MG. Molecular imaging of metastatic potential. J
Nucl Med. 2008;49 Suppl 2:96S-112S
Woelfle MA, Xu Y, Qin X, Johnson CH. Circadian rhythms of superhelical status of DNA in cyanobacteria.
Proceedings of the National Academy of Sciences of the United States of America. 2007;104:18819-18824
Wohler JE, Smith SS, Zinn KR, Bullard DC, Barnum SR. Γδ t cells in experimental autoimmune
encephalomyelitis: Early trafficking events and cytokine requirements. European Journal of Immunology.
2009;39:1516-1526
Wolbank S, Peterbauer A, Wassermann E, Hennerbichler S, Voglauer R, van Griensven M, Duba HC, Gabriel C,
Redl H. Labelling of human adipose-derived stem cells for non-invasive in vivo cell tracking. Cell and Tissue
Banking. 2007;8:163-177
Woldemichael G, Vasselli J, Gardella R, Mckee T, Linehan W, McMahon J. Development of a cell-based reporter
assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression. Journal of
Biomolecular Screening. 2006;11:678
Wolf AM, Eller K, Zeiser R, Durr C, Gerlach UV, Sixt M, Markut L, Gastl G, Rosenkranz AR, Wolf D. The
sphingosine 1-phosphate receptor agonist fty720 potently inhibits regulatory t cell proliferation in vitro and in
vivo. J Immunol. 2009;183:3751-3760
Wolfson M. Novel applications & perfluorochemical-associated drug delivery. ASAIO Journal. 2006;52:490
Woll PS, Grzywacz B, Tian X, Marcus RK, Knorr DA, Verneris MR, Kaufman DS. Human embryonic stem cells
differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity. Blood.
2009;113:6094-6101
Wong CC, Wong CM, Tung EK, Man K, Ng IO. Rho-kinase 2 is frequently overexpressed in hepatocellular
carcinoma and involved in tumor invasion. Hepatology. 2009;49:1583-1594
Wong D, Potter W, Brasic J. Proof of concept: Functional models for drug development in humans.
Neuropsychopharmacology: The Fifth Generation of Progress. Baltimore, MD: The American College of
Neuropsychopharmacology and Lippincott Williams & Wilkins. 2002:457–473
Wong G, Contag I, Stevenson D. The effectiveness of oral tin mesoporphyrin prophylaxis in reducing bilirubin
production after an oral heme load in a transgenic mouse model. Biology of the Neonate. 2006;89:139-146
Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E. Antivascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosisrelated tumors. Cancer Res. 2010;70:3483-3493
Wong JW, Artemov D, Tryggestad E, Winnard P. Combining x-ray and optical 3d imaging to guide focal
irradiation of molecular targets in mice. International Journal of Radiation Oncology Biology Physics.
2009;75:S42-S43
Wong S, Argyros O, Coutelle C, Harbottle R. Non-viral s/mar vectors replicate episomally in vivo when provided
with a selective advantage. Gene Therapy. 2010
Wong WW, Doyle TC, Cheung P, Olson TM, Reisler E. Functional studies of yeast actin mutants corresponding to
human cardiomyopathy mutations. Journal of Muscle Research and Cell Motility. 2001;22:665-674
Woodard LE, Keravala A, Jung WE, Wapinski OL, Yang Q, Felsher DW, Calos MP. Impact of hydrodynamic
injection and phic31 integrase on tumor latency in a mouse model of myc-induced hepatocellular carcinoma.
PLoS ONE. 2010
Woodrow KA, Cu Y, Booth CJ, Saucier-Sawyer JK, Wood MJ, Saltzman WM. Intravaginal gene silencing using
biodegradable polymer nanoparticles densely loaded with small-interfering rna. Nat Mater. 2009;8:526-533
Woodruff ML, Olshevskaya EV, Savchenko AB, Peshenko IV, Barrett R, Bush RA, Sieving PA, Fain GL, Dizhoor
AM. Constitutive excitation by gly90asp rhodopsin rescues rods from degeneration caused by elevated
production of cgmp in the dark. Journal of Neuroscience. 2007;27:8805-8815
Woods NT, Yamaguchi H, Lee FY, Bhalla KN, Wang HG. Anoikis, initiated by mcl-1 degradation and bim
induction, is deregulated during oncogenesis. Cancer Res. 2007;67:10744-10752
Woolfenden S, Zhu H, Charest A. A cre/loxp conditional luciferase reporter transgenic mouse for
bioluminescence monitoring of tumorigenesis. Genesis. 2009
Wright CJ, Zhuang T, La P, Yang G, Dennery PA. Hyperoxia-induced nf-κb activation occurs via a maturationally
2765.
2766.
2767.
2768.
2769.
2770.
2771.
2772.
2773.
2774.
2775.
2776.
2777.
2778.
2779.
2780.
2781.
2782.
2783.
2784.
2785.
2786.
2787.
2788.
2789.
2790.
sensitive atypical pathway. Am J Physiol Lung Cell Mol Physiol. 2009;296:L296-306
Wright JS, Jin R, Novick RP. Transient interference with staphylococcal quorum sensing blocks abscess
formation. Proceedings of the National Academy of Sciences of the United States of America.
2005;102:1691-1696
Wright JS, Traber KE, Corrigan R, Benson SA, Musser JM, Novick RP. The agr radiation: An early event in the
evolution of staphylococci†. Journal of Bacteriology. 2005;187:5585-5594
Wruck CJ, Fragoulis A, Gurzynski A, Brandenburg LO, Kan YW, Chan K, Hassenpflug J, Freitag-Wolf S, Varoga D,
Lippross S, Pufe T. Role of oxidative stress in rheumatoid arthritis: Insights from the nrf2-knockout mice.
Annals of the rheumatic diseases. 2011;70:844-850
Wu A, Oh S, Gharagozlou S, Vedi R, Ericson K, Low W, Chen W, Ohlfest J. In vivo vaccination with tumor cell
lysate plus cpg oligodeoxynucleotides eradicates murine glioblastoma. Journal of Immunotherapy.
2007;30:789
Wu CC, Lin EH, Lee YC, Tai CJ, Kuo TH, Wang HE, Luo TY, Fu YK, Chen HJ, Sun MD, Wu CH, Wu CW, Leu SJ,
Deng WP. Identification of a new peptide for fibrosarcoma tumor targeting and imaging in vivo. Journal of
biomedicine & biotechnology. 2010;2010:167045
Wu CH, van Riggelen J, Yetil A, Fan AC, Bachireddy P, Felsher DW. Cellular senescence is an important
mechanism of tumor regression upon c-myc inactivation. Proceedings of the National Academy of Sciences of
the United States of America. 2007;104:13028-13033
Wu J, Cao F, Dutta S, Xie X, Kim A, Chungfat N, Gambhir S, Mathewson S, Connolly A, Brown M, Wang E.
Proteomic analysis of reporter genes for molecular imaging of transplanted embryonic stem cells. PROTEOMICS.
2006;9999:NA
Wu J, Chen I, Sundaresan G, Min J, De A, Qiao J, Fishbein M, Gambhir S. Molecular imaging of cardiac cell
transplantation in living animals using optical bioluminescence and positron emission tomography.
Circulation. 2003;108:1302
Wu J, Spin J, Cao F, Lin S, Xie X, Gheysens O, Chen I, Sheikh A, Robbins R, Tsalenko A. Transcriptional profiling
of reporter genes used for molecular imaging of embryonic stem cell transplantation. Physiological genomics.
2006;25:29
Wu JC, Inubushi M, Sundaresan G, Schelbert HR, Gambhir SS. Optical imaging of cardiac reporter gene
expression in living rats. Circulation. 2002;105:1631-1634
Wu JC, Li Z, Xu L, Giffard RG, Wu J, Cooke JP. Transplantation of embryonic stem cell derived endothelial cells
promote functional recovery after cerebral ischemia. Circulation. 2006;114:627
Wu JC, Sundaresan G, Iyer M, Gambhir SS. Noninvasive optical imaging of firefly luciferase reporter gene
expression in skeletal muscles of living mice. Mol Ther. 2001;4:297-306
Wu KD, Cho YS, Katz J, Ponomarev V, Chen-Kiang S, Danishefsky SJ, Moore MAS. Investigation of antitumor
effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo. Proceedings of the
National Academy of Sciences of the United States of America. 2005;102:10640-10645
Wu KD, Zhou L, Burtrum D, Ludwig DL, Moore MA. Antibody targeting of the insulin-like growth factor i
receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor
proliferation and angiogenesis. Cancer Immunol Immunother. 2007;56:343-357
Wu L, Johnson M, Sato M. Transcriptionally targeted gene therapy to detect and treat cancer. Trends Mol Med.
2003;9:421
Wu SL, Chen JC, Li CC, Lo HY, Ho TY, Hsiang CY. Vanillin improves and prevents trinitrobenzene sulfonic acidinduced colitis in mice. J Pharmacol Exp Ther. 2009;330:370-376
Wu W, Lockhart SR, Pujol C, Srikantha T, Soll DR. Heterozygosity of genes on the sex chromosome regulates
candida albicans virulence. Mol Microbiol. 2007;64:1587-1604
Wu Y, Cai W, Chen X. Near-infrared fluorescence imaging of tumor integrin alpha(v)beta (3) expression with cy7labeled rgd multimers. Mol Imaging Biol. 2006
Wu Y, Ino Y, Todo T. The use of third generation oncolytic hsv-1 expressing luciferase for demonstration of realtime biodistribution and dynamics. Molecular Therapy. 2010;18:S323-S324
Wu Y, McRoberts K, Berr SS, Frierson HF, Jr., Conaway M, Theodorescu D. Neuromedin u is regulated by the
metastasis suppressor rhogdi2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia.
Oncogene. 2007;26:765-773
Wurdak H, Zhu S, Romero A, Lorger M, Watson J, Chiang CY, Zhang J, Natu VS, Lairson LL, Walker JR, Trussell
CM, Harsh GR, Vogel H, Felding-Habermann B, Orth AP, Miraglia LJ, Rines DR, Skirboll SL, Schultz PG. An rnai
screen identifies trrap as a regulator of brain tumor-initiating cell differentiation. Cell stem cell. 2010;6:37-47
Xia M, Hull L, Thomas C, Gabra B, Li N, Li P, Dewey W. Dynamic in vivo imaging of nadph oxidase gene
expression to monitor its involvement in morphine’s actions. The FASEB Journal. 2008;22:1125.1113
Xia W, Labrinidis A, Evdokiou A, Holmes MD, Reynolds PN. Fgk45 immune-based treatment may cure
mesothelioma in mice with or without combination with viral therapy. Respirology. 2010;15:A75
Xiao K, Luo J, Fowler WL, Li Y, Lee JS, Xing L, Cheng RH, Wang L, Lam KS. A self-assembling nanoparticle for
paclitaxel delivery in ovarian cancer. Biomaterials. 2009;30:6006-6016
Xiao L, Zhang Y, Liu Z, Yang M, Pu L, Pan D. Synthesis of the cyanine 7 labeled neutrophil-specific agents for
noninvasive near infrared fluorescence imaging. Bioorg Med Chem Lett. 2010;20:3515-3517
Xie D, Gore C, Liu J, Pong RC, Mason R, Hao G, Long M, Kabbani W, Yu L, Zhang H, Chen H, Sun X, Boothman
2791.
2792.
2793.
2794.
2795.
2796.
2797.
2798.
2799.
2800.
2801.
2802.
2803.
2804.
2805.
2806.
2807.
2808.
2809.
2810.
2811.
2812.
2813.
2814.
2815.
2816.
DA, Min W, Hsieh JT. Role of dab2ip in modulating epithelial-to-mesenchymal transition and prostate cancer
metastasis. Proc Natl Acad Sci U S A. 2010;107:2485-2490
Xie X, Cao F, Sheikh AY, Li Z, Connolly AJ, Pei X, Li RK, Robbins RC, Wu JC. Genetic modification of embryonic
stem cells with vegf enhances cell survival and improves cardiac function. Cloning Stem Cells. 2007;9:549-563
Xie X, Chan KS, Cao F, Huang M, Li Z, Lee A, Weissman IL, Wu JC. Imaging of stat3 signaling pathway during
mouse embryonic stem cell differentiation. Stem Cells Dev. 2009;18:205-214
Xie X, Deng W, Yang M, Tang J, Wang X, Wei W, Xie Z, Xiao X, Liu P, Lang J, Hung MC. "Visa" nanoparticles to
breast cancer. Cancer Res. 2009;69:818S
Xie X, Hsu JL, Choi MG, Xia W, Yamaguchi H, Chen CT, Trinh BQ, Lu Z, Ueno NT, Wolf JK, Bast RC, Hung MC. A
novel htert promoter-driven e1a therapeutic for ovarian cancer. Mol Cancer Ther. 2009;8:2375-2382
Xie X, Luo Z, Slawin KM, Spencer DM. The ezc-prostate model: Noninvasive prostate imaging in living mice. Mol
Endocrinol. 2004;18:722-732
Xie X, Xia W, Li Z, Kuo H, Liu Y, Ding Q, Zhang S, Spohn B, Yang Y. Targeted expression of bikdd eradicates
pancreatic tumors in noninvasive imaging models. Cancer Cell. 2007;12:52-65
Xie Y, Yin T, Wiegraebe W, He XC, Miller D, Stark D, Perko K, Alexander R, Schwartz J, Grindley JC, Park J, Haug
JS, Wunderlich JP, Li H, Zhang S, Johnson T, Feldman RA, Li L. Detection of functional haematopoietic stem cell
niche using real-time imaging. Nature. 2009;457:97-101
Xin K, Jounai N, Someya K, Honma K, Mizuguchi H, Naganawa S, Kitamura K, Hayakawa T, Saha S, Takeshita F.
Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces
protective immunity against hiv. Gene Therapy. 2005;12:1769-1777
Xin L, Lawson DA, Witte ON. The sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation
that can initiate prostate tumorigenesis. Proceedings of the National Academy of Sciences of the United States of
America. 2005;102:6942-6947
Xin X, Abrams TJ, Hollenbach PW, Rendahl KG, Tang Y, Oei YA, Embry MG, Swinarski DE, Garrett EN, Pryer NK,
Trudel S, Jallal B, Mendel DB, Heise CC. Chir-258 is efficacious in a newly developed fibroblast growth factor
receptor 3-expressing orthotopic multiple myeloma model in mice. Clin Cancer Res. 2006;12:4908-4915
Xing Y, Lu X, Pua EC, Zhong P. The effect of high intensity focused ultrasound treatment on metastases in a
murine melanoma model. Biochemical and Biophysical Research Communications. 2008;375:645-650
Xing Y, Pua EC, Lu X, Zhong P. Low-amplitude ultrasound enhances hydrodynamic-based gene delivery to rat
kidney. Biochemical and Biophysical Research Communications. 2009;386:217-222
Xing Y, So MK, Koh AL, Sinclair R, Rao J. Improved qd-bret conjugates for detection and imaging. Biochem
Biophys Res Commun. 2008
Xiong YQ, Willard J, Kadurugamuwa JL, Yu J, Francis KP, Bayer AS. Real-time in vivo bioluminescent imaging
for evaluating the efficacy of antibiotics in a rat staphylococcus aureus endocarditis model. Antimicrobial
Agents and Chemotherapy. 2005;49:380-387
Xiong Z, Gharagozlou S, Vengco I, Chen W, Ohlfest JR. Effective cpg immunotherapy of breast carcinoma
prevents but fails to eradicate established brain metastasis. Clin Cancer Res. 2008;14:5484-5493
Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, Tamaki A, Matsunaga J, Takahashi RU, Takata T, Shimamoto A,
Ochiya T, Tahara H. Mir-22 represses cancer progression by inducing cellular senescence. The Journal of cell
biology. 2011;193:409-424
Xu H, Rice BW. In-vivo fluorescence imaging with a multivariate curve resolution spectral unmixing technique. J
Biomed Opt. 2009;14:064011
Xu RX, Povoski SP. Diffuse optical imaging and spectroscopy for cancer. Expert Review of Medical Devices.
2007;4:83-95
Xu X, Miller SA, Baysal-Gurel F, Gartemann KH, Eichenlaub R, Rajashekara G. Bioluminescence imaging of
clavibacter michiganensis subsp. Michiganensis infection of tomato seeds and plants. Appl Environ Microbiol.
2010;76:3978-3988
Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW. Senescence
and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 2007
Yaghoubi S, Creusot R, Ray P, Fathman C, Gambhir S. Multimodality imaging of t-cell hybridoma trafficking in
collagen-induced arthritic mice: Image-based estimation of the number of cells accumulating in mouse paws.
Journal of biomedical optics. 2007;12:064025
Yagi N, Manabe I, Tottori T, Ishihara A, Ogata F, Kim JH, Nishimura S, Fujiu K, Oishi Y, Itaka K, Kato Y, Yamauchi
M, Nagai R. A nanoparticle system specifically designed to deliver short interfering rna inhibits tumor growth in
vivo. Cancer Res. 2009;69:6531-6538
Yamada M, Gurney P, Chung J, Kundu P, Drukker M, Smith A, Weissman I, Nishimura D, Robbins R, Yang P.
Manganese guided cellular mri of human embryonic stem cell and human bone marrow stromal cell viability.
Magnetic Resonance in Medicine. 2009;62:1047-1054
Yamaguchi A, Murakami T, Takahashi M, Kobayashi E, Sugawara Y. Luminescence imaging of regenerating free
bone graft in rats. Plastic and reconstructive surgery. 2011;127:78-87
Yamaguchi S, Iikubo E, Hirose N, Kitajima T, Katagiri S, Kawamori A, Fujii-Taira I, Matsushima T, Homma KJ.
Bioluminescence imaging of c-fos gene expression accompanying filial imprinting in the newly hatched chick
brain. Neurosci Res. 2010
Yamashita K, Yoshioka Y, Higashisaka K, Mimura K, Morishita Y, Nozaki M, Yoshida T, Ogura T, Nabeshi H,
2817.
2818.
2819.
2820.
2821.
2822.
2823.
2824.
2825.
2826.
2827.
2828.
2829.
2830.
2831.
2832.
2833.
2834.
2835.
2836.
2837.
2838.
2839.
2840.
Nagano K, Abe Y, Kamada H, Monobe Y, Imazawa T, Aoshima H, Shishido K, Kawai Y, Mayumi T, Tsunoda S, Itoh
N, Yoshikawa T, Yanagihara I, Saito S, Tsutsumi Y. Silica and titanium dioxide nanoparticles cause pregnancy
complications in mice. Nature nanotechnology. 2011;6:321-328
Yan E, Fu Y, Wang X, Ding Y, Qian H, Wang C-H, Hu Y, Jiang X. Hollow chitosan-silica nanospheres for
doxorubicin delivery to cancer cells with enhanced antitumor effect in vivo. Journal of Materials Chemistry.
2011;21:3147-3155
Yan W, Xiao D, Yao K. Combined bioluminescence and fluorescence imaging visualizing orthotopic lung
adenocarcinoma xenograft in vivo. Acta biochimica et biophysica Sinica. 2011;43:595-600
Yanagihara K, Takigahira M, Takeshita F, Komatsu T, Nishio K, Hasegawa F, Ochiya T. A photon counting
technique for quantitatively evaluating progression of peritoneal tumor dissemination. Cancer Res.
2006;66:7532
Yanagisawa S, Kadouchi I, Yokomori K, Hirose M, Hakozaki M, Hojo H, Maeda K, Kobayashi E, Murakami T.
Identification and metastatic potential of tumor-initiating cells in malignant rhabdoid tumor of the kidney. Clin
Cancer Res. 2009;15:3014-3022
Yang E, Boire A, Agarwal A, Nguyen N, O'Callaghan K, Tu P, Kuliopulos A, Covic L. Blockade of par1 signaling
with cell-penetrating pepducins inhibits akt-survival pathways in breast cancer cells and suppresses tumor
survival and metastasis. Cancer Res. 2009;69:6223-6231
Yang G, Abate A, George AG, Weng YH, Dennery PA. Maturational differences in lung nf-kappab activation and
their role in tolerance to hyperoxia. J Clin Invest. 2004;114:669-678
Yang H, Joo KI, Ziegler L, Wang P. Cell type-specific targeting with surface-engineered lentiviral vectors codisplaying okt3 antibody and fusogenic molecule. Pharmaceutical Research. 2009;26:1432-1445
Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, Zhang X, Zhang L, Kim WY, Olumi AF, Kaelin WG. Pvhl
acts as an adapter to promote the inhibitory phosphorylation of the nf-κb agonist card9 by ck2. Molecular Cell.
2007;28:15-27
Yang H, Zeigler L, Joo KI, Cho T, Lei Y, Wang P. Gamma-retroviral vectors enveloped with an antibody and an
engineered fusogenic protein achieved antigen-specific targeting. Biotechnology and Bioengineering.
2008;101:357-368
Yang J, Bielenberg DR, Rodig SJ, Doiron R, Clifton MC, Kung AL, Strong RK, Zurakowski D, Moses MA.
Lipocalin 2 promotes breast cancer progression. Proceedings of the National Academy of Sciences of the United
States of America. 2009;106:3913-3918
Yang J, Pan WH, Clawson GA, Richmond A. Systemic targeting inhibitor of κb kinase inhibits melanoma tumor
growth. Cancer Res. 2007;67:3127-3134
Yang J, Richmond AJ. Monitoring nf-kappab mediated chemokine transcription in tumorigenesis. Methods
Enzymol. 2009;460:347-355
Yang J, Zaja-Milatovic S, Thu YM, Lee F, Smykla R, Richmond A. Molecular determinants of melanoma
malignancy: Selecting targets for improved efficacy of chemotherapy. Mol Cancer Ther. 2009;8:636-647
Yang K, Tang Y, Habermehl GK, Iczkowski KA. Stable alterations of cd44 isoform expression in prostate cancer
cells decrease invasion and growth and alter ligand binding and chemosensitivity. BMC Cancer. 2010;10:16
Yang KS, Ilagan MX, Piwnica-Worms D, Pike LJ. Luciferase fragment complementation imaging of
conformational changes in the epidermal growth factor receptor. J Biol Chem. 2009;284:7474-7482
Yang L, Clarke MJ, Carlson BL, Mladek AC, Schroeder MA, Decker P, Wu W, Kitange GJ, Grogan PT, Goble JM,
Uhm J, Galanis E, Giannini C, Lane HA, James CD, Sarkaria JN. Pten loss does not predict for response to rad001
(everolimus) in a glioblastoma orthotopic xenograft test panel. Clin Cancer Res. 2008;14:3993-4001
Yang L, Jackson E, Woerner B, Perry A, Piwnica-Worms D, Rubin J. Blocking cxcr4-mediated cyclic amp
suppression inhibits brain tumor growth in vivo. Cancer Res. 2007;67:651
Yang L, Peng XH, Wang YA, Wang X, Cao Z, Ni C, Karna P, Zhang X, Wood WC, Gao X, Nie S, Mao H. Receptortargeted nanoparticles for in vivo imaging of breast cancer. Clinical Cancer Research. 2009;15:4722-4732
Yang SH, Hong YK, Jeun SS, Kim IS, Hong JT, Sung JH, Son BC, Lee SW, Kim MC, Lee KS. Assessment of
cetuximab efficacy by bioluminescence monitoring of intracranial glioblastoma xenograft in mouse. J
Neurooncol. 2009;95:23-28
Yang W, Rozan L, McDonald E, Navaraj A, Liu J, Matthew E, Wang W, Dicker D, El-Deiry W. Carps are ubiquitin
ligases that promote mdm2-independent p53 and phospho-p53ser20 degradation. Journal of Biological
Chemistry. 2007;282:3273
Yang X, Peterson L, Thieringer R, Deignan JL, Wang X, Zhu J, Wang S, Zhong H, Stepaniants S, Beaulaurier J,
Wang IM, Rosa R, Cumiskey AM, Luo JMJ, Luo Q, Shah K, Xiao J, Nickle D, Plump A, Schadt EE, Lusis AJ, Lum
PY. Identification and validation of genes affecting aortic lesions in mice. Journal of Clinical Investigation.
2010;120:2414-2422
Yang X-Z, Dou S, Sun T-M, Mao C-Q, Wang H-X, Wang J. Systemic delivery of sirna with cationic lipid assisted
peg-pla nanoparticles for cancer therapy. Journal of Controlled Release.In Press, Uncorrected Proof
Yang Y, Contag CH, Felsher D, Shachaf CM, Cao Y, Herzenberg LA, Tung JW. The e47 transcription factor
negatively regulates cd5 expression during thymocyte development. Proceedings of the National Academy of
Sciences of the United States of America. 2004;101:3898-3902
Yang Z, Leon J, Martin M, Harder JW, Zhang R, Liang D, Lu W, Tian M, Gelovani JG, Qiao A, Li C.
Pharmacokinetics and biodistribution of near-infrared fluorescence polymeric nanoparticles. Nanotechnology.
2841.
2842.
2843.
2844.
2845.
2846.
2847.
2848.
2849.
2850.
2851.
2852.
2853.
2854.
2855.
2856.
2857.
2858.
2859.
2860.
2861.
2862.
2863.
2864.
2009;20:165101
Yang Z, Zheng S, Harrison WJ, Harder J, Wen X, Gelovani JG, Qiao A, Li C. Long-circulating near-infrared
fluorescence core-crosslinked polymeric micelles: Synthesis, characterization, and dual nuclear/optical imaging.
Biomacromolecules. 2007;8:3422-3428
Yano A, Tsutsumi S, Soga S, Lee MJ, Trepel J, Osada H, Neckers L. Inhibition of hsp90 activates osteoclast c-src
signaling and promotes growth of prostate carcinoma cells in bone. Proceedings of the National Academy of
Sciences of the United States of America. 2008;105:15541-15546
Yao H, Ng SS, Tucker WO, Tsang YK, Man K, Wang XM, Chow BK, Kung HF, Tang GP, Lin MC. The gene
transfection efficiency of a folate-pei600-cyclodextrin nanopolymer. Biomaterials. 2009;30:5793-5803
Yates M, Tauchi M, Katsuoka F, Flanders K, Liby K, Honda T, Gribble G, Johnson D, Johnson J, Burton N.
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of nrf2regulated genes. Mol Cancer Ther. 2007;6:154
Yazici C, Yanoso L, Xie C, Reynolds DG, Samulski RJ, Samulski J, Yannariello-Brown J, Gertzman AA, Zhang X,
Awad HA, Schwarz EM. The effect of surface demineralization of cortical bone allograft on the properties of
recombinant adeno-associated virus coatings. Biomaterials. 2008;29:3882-3887
Ye F, Zhou F, Bedolla RG, Jones T, Lei X, Kang T, Guadalupe M, Gao SJ. Reactive oxygen species hydrogen
peroxide mediates kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS pathogens.
2011;7:e1002054
Ye X, Han SJ, Tsai SY, DeMayo FJ, Xu J, Tsai MJ, O'Malley BW. Roles of steroid receptor coactivator (src)-1 and
transcriptional intermediary factor (tif) 2 in androgen receptor activity in mice. Proceedings of the National
Academy of Sciences of the United States of America. 2005;102:9487-9492
Yegutkin GG, Marttila-Ichihara F, Karikoski M, Niemela J, Laurila JP, Elima K, Jalkanen S, Salmi M. Altered
purinergic signaling in cd73-deficient mice inhibits tumor progression. European journal of immunology.
2011;41:1231-1241
Yeh SP, Lo WJ, Chang YC, Tsai WJ, Lin CL, Liao YM. Tumor homing activity of bone marrow-derived
mesenchymal stem cell is highly various among different tumors on syngeneic mouse model using real-time in
vivo imaging technique. Blood. 2009;114
Yen L, Stockwell BR, Mulligan RC. A mammalian cell-based assay for screening inhibitors of rna cleavage.
Riboswitches. 2009:335-347.
Yen L, Svendsen J, Lee J, Gray J, Magnier M, Baba T, D'Amato R, Mulligan R. Exogenous control of mammalian
gene expression through modulation of rna self-cleavage. Nature. 2004;431:471-476
Yeom CJ, Chung JK, Kang JH, Jeon YH, Kim KI, Jin YN, Lee YM, Jeong JM, Lee DS. Visualization of hypoxiainducible factor-1 transcriptional activation in c6 glioma using luciferase and sodium iodide symporter genes. J
Nucl Med. 2008;49:1489-1497
Yi C, Troutman S, Fera D, Stemmer-Rachamimov A, Avila JL, Christian N, Persson NL, Shimono A, Speicher DW,
Marmorstein R, Holmgren L, Kissil JL. A tight junction-associated merlin-angiomotin complex mediates merlin's
regulation of mitogenic signaling and tumor suppressive functions. Cancer cell. 2011;19:527-540
Yi F, Xia M, Li N, Zhang C, Tang L, Li PL. Contribution of guanine nucleotide exchange factor vav2 to
hyperhomocysteinemic glomerulosclerosis in rats. Hypertension. 2009;53:90-96
Yin D, Ong JM, Hu J, Desmond JC, Kawamata N, Konda BM, Black KL, Koeffler HP. Suberoylanilide hydroxamic
acid, a histone deacetylase inhibitor: Effects on gene expression and growth of glioma cells in vitro and in vivo.
Clin Cancer Res. 2007;13:1045-1052
Yin J, Pollock C, Tracy K, Chock M, Martin P, Oberst M, Kelly K. Activation of the ralgef/ral pathway promotes
prostate cancer metastasis to bone▿‡. Molecular and Cellular Biology. 2007;27:7538-7550
Yong RL, Shinojima N, Fueyo J, Gumin J, Vecil GG, Marini FC, Bogler O, Andreeff M, Lang FF. Human bone
marrow-derived mesenchymal stem cells for intravascular delivery of oncolytic adenovirus delta24-rgd to human
gliomas. Cancer Res. 2009;69:8932-8940
Yoon YS, Ryu D, Lee MW, Hong S, Koo SH. Adiponectin and thiazolidinedione targets crtc2 to regulate hepatic
gluconeogenesis. Experimental and Molecular Medicine. 2009;41:577-583
Yori JL, Seachrist DD, Johnson E, Lozada KL, Abdul-Karim FW, Chodosh LA, Schiemann WP, Keri RA. Kruppellike factor 4 inhibits tumorigenic progression and metastasis in a mouse model of breast cancer. Neoplasia.
2011;13:601-610
Yoshikawa D, Ojima H, Kokubu A, Ochiya T, Kasai S, Hirohashi S, Shibata T. Vandetanib (zd6474), an inhibitor of
vegfr and egfr signalling, as a novel molecular-targeted therapy against cholangiocarcinoma. British Journal of
Cancer. 2009;100:1257-1266
Yoshimitsu M, Sato T, Tao K, Walia JS, Rasaiah VI, Sleep GT, Murray GJ, Poeppl AG, Underwood J, West L, Brady
RO, Medin JA. Bioluminescent imaging of a marking transgene and correction of fabry mice by neonatal
injection of recombinant lentiviral vectors. Proceedings of the National Academy of Sciences of the United
States of America. 2004;101:16909-16914
Youn J, Won N, Kim S, Choi J. Near-infrared quantum dots imaging in the mouse brain. Biomedical Optics
(BIOMED). 2008
Young DD, Lusic H, Lively MO, Yoder JA, Deiters A. Gene silencing in mammalian cells with light-activated
antisense agents. Chembiochem. 2008;9:2937-2940
Yu J, Bryant AP, Marra A, Lonetto MA, Ingraham KA, Chalker AF, Holmes DJ, Holden D, Rosenberg M, McDevitt
2865.
2866.
2867.
2868.
2869.
2870.
2871.
2872.
2873.
2874.
2875.
2876.
2877.
2878.
2879.
2880.
2881.
2882.
2883.
2884.
2885.
2886.
D. Characterization of the streptococcus pneumoniae nadh oxidase that is required for infection. Microbiology.
2001;147:431-438
Yu J, Huang NF, Wilson KD, Velotta JB, Huang M, Li Z, Lee A, Robbins RC, Cooke JP, Wu JC. Nachrs mediate
human embryonic stem cell-derived endothelial cells: Proliferation, apoptosis, and angiogenesis. PLoS One.
2009;4
Yu J, Kadurugamuwa J, Kimura R, Sin L, Tomkiel D, Francis K. Real time detection and comparison of different
bioluminescent biofilm-forming bacteria in an experimental murine model. Abstracts of the General Meeting of
the American Society for Microbiology. 2003;103:D-169
Yu J, Lee H, Hur K, Kwak M, Han T, Kim W, Song S, Yanagihara K, Yang H. The antitumor effect of a
thermosensitive polymeric hydrogel containing paclitaxel in a peritoneal carcinomatosis model. Investigational
New Drugs. 2010:1-7
Yu J, Wu J, Francis KP, Purchio TF, Kadurugamuwa JL. Monitoring in vivo fitness of rifampicin-resistant
staphylococcus aureus mutants in a mouse biofilm infection model. Journal of Antimicrobial Chemotherapy.
2005;55:528-534
Yu JJ, Robb VA, Morrison TA, Ariazi EA, Karbowniczek M, Astrinidis A, Wang C, Hernandez-Cuebas L, Seeholzer
LF, Nicolas E, Hensley H, Jordan VC, Walker CL, Henske EP. Estrogen promotes the survival and pulmonary
metastasis of tuberin-null cells. Proceedings of the National Academy of Sciences of the United States of
America. 2009;106:2635-2640
Yu XZ, Valenzuela J, Iclozan C, Hossain M, Hopewell E, Bronk C, Wang J, Celis E, Engelman R, Waller EK, Blazar
BR, Beg A. Targeting pkctheta inhibits alloreactivity and graft-versus-host disease while preserving graftversus-leukemia and anti-infection activities. Blood. 2009;114
Yu Z, Li S, Brader P, Chen N, Yu YA, Zhang Q, Szalay AA, Fong Y, Wong RJ. Oncolytic vaccinia therapy of
squamous cell carcinoma. Mol Cancer. 2009;8:45
Yuan L, Siegel M, Choi K, Khosla C, Miller CR, Jackson EN, Piwnica-Worms D, Rich KM. Transglutaminase 2
inhibitor, kcc009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic
glioblastomas to chemotherapy. Oncogene. 2006
Yuasa T, Nogawa M, Kimura S, Yokota A, Sato K, Segawa H, Kuroda J, Maekawa T. A third-generation
bisphosphonate, minodronic acid (ym529), augments the interferon alpha/beta-mediated inhibition of renal cell
cancer cell growth both in vitro and in vivo. Clin Cancer Res. 2005;11:853-859
Yui Y, Yoshioka K, Itoh K. Topoisomerase i inhibitors suppress metastasis of osteosarcoma by reducing
migration. Clinical and Experimental Metastasis. 2009;26:919
Yurek DM, Fletcher AM, Smith GM, Seroogy KB, Ziady AG, Molter J, Kowalczyk TH, Padegimas L, Cooper MJ.
Long-term transgene expression in the central nervous system using DNA nanoparticles. Mol Ther.
2009;17:641-650
Yvon E, Vecchio MD, Savoldo B, Hoyos V, Dutour A, Anichini A, Dotti G, Brenner MK. Immunotherapy of
metastatic melanoma using genetically engineered gd2-specific t cells. Clinical Cancer Research.
2009;15:5852-5860
Zabala M, Alzuguren P, Benavides C, Crettaz J, Gonzalez-Aseguinolaza G, Ortiz de Solorzano C, GonzalezAparicio M, Kramer MG, Prieto J, Hernandez-Alcoceba R. Evaluation of bioluminescent imaging for noninvasive
monitoring of colorectal cancer progression in the liver and its response to immunogene therapy. Mol Cancer.
2009;8:2
Zachos T, Bertone A, Wassenaar P, Weisbrode S. Rodent models for the study of articular fracture healing.
Investigative Surgery. 2007;20:87-95
Zachos T, Diggs A, Weisbrode S, Bartlett J, Bertone A. Mesenchymal stem cell-mediated gene delivery of bone
morphogenetic protein-2 in an articular fracture model. Mol Ther. 2007;15:1543-1550
Zachos T, Shields K, Bertone A. Gene mediated osteogenic differentiation of stem cells by bone morphogenetic
proteins 2 or 6. Journal of Orthopaedic Research. 2006;24:1279-1291
Zaharoff DA, Rogers CJ, Hance KW, Schlom J, Greiner JW. Chitosan solution enhances both humoral and cellmediated immune responses to subcutaneous vaccination. Vaccine. 2007;25:2085-2094
Zaharoff DA, Rogers CJ, Hance KW, Schlom J, Greiner JW. Chitosan solution enhances the immunoadjuvant
properties of gm-csf. Vaccine. 2007;25:8673-8686
Zahid M, Phillips BE, Albers SM, Giannoukakis N, Watkins SC, Robbins PD. Identification of a cardiac specific
protein transduction domain by in vivo biopanning using a m13 phage peptide display library in mice. PLoS
One. 2010;5
Zaitseva M, Kapnick SM, Scott J, King LR, Manischewitz J, Sirota L, Kodihalli S, Golding H. Application of
bioluminescence imaging to the prediction of lethality in vaccinia virus-infected mice. J Virol.
2009;83:10437-10447
Zakrzewski JL, Kochman AA, Lu SX, Terwey TH, Kim TD, Hubbard VM, Muriglan SJ, Suh D, Smith OM, Grubin J,
Patel N, Chow A, Cabrera-Perez J, Radhakrishnan R, Diab A, Perales MA, Rizzuto G, Menet E, Pamer EG, Heller G,
Zuniga-Pflucker JC, Alpdogan O, van den Brink MR. Adoptive transfer of t-cell precursors enhances t-cell
reconstitution after allogeneic hematopoietic stem cell transplantation. Nat Med. 2006;12:1039-1047
Zakrzewski JL, Suh D, Markley JC, Smith OM, King C, Goldberg GL, Jenq R, Holland AM, Grubin J, Cabrera-Perez
J, Brentjens RJ, Lu SX, Rizzuto G, Sant’Angelo DB, Riviere I, Sadelain M, Heller G, Zúñiga-Pflücker JC, Lu C, van
den Brink MRM. Tumor immunotherapy across mhc barriers using allogeneic t-cell precursors. Nature
2887.
2888.
2889.
2890.
2891.
2892.
2893.
2894.
2895.
2896.
2897.
2898.
2899.
2900.
2901.
2902.
2903.
2904.
2905.
2906.
2907.
2908.
2909.
2910.
2911.
Biotechnology. 2008;26:453-461
Zangani M, Carlsen H, Kielland A, Os A, Hauglin H, Blomhoff R, Munthe LA, Bogen B. Tracking early
autoimmune disease by bioluminescent imaging of nf-kappab activation reveals pathology in multiple organ
systems. Am J Pathol. 2009;174:1358-1367
Zarovni N, Vago R, Fabbrini MS. Saporin suicide gene therapy. Gene therapy of cancer. 2009:261-283.
Zeamari S, Rumping G, Floot B, Lyons S, Stewart FA. In vivo bioluminescence imaging of locally disseminated
colon carcinoma in rats. British Journal of Cancer. 2004;90:1259-1264
Zeiser R, Leveson-Gower DB, Zambricki EA, Kambham N, Beilhack A, Loh J, Hou JZ, Negrin RS. Differential
impact of mammalian target of rapamycin inhibition on cd4+cd25+foxp3+ regulatory t cells compared with
conventional cd4+ t cells. Blood. 2008;111:453-462
Zeiser R, Nguyen VH, Beilhack A, Buess M, Schulz S, Baker J, Contag CH, Negrin RS. Inhibition of cd4+cd25+
regulatory t-cell function by calcineurin-dependent interleukin-2 production. Blood. 2006;108:390-399
Zeiser R, Nguyen VH, Hou JZ, Beilhack A, Zambricki E, Buess M, Contag CH, Negrin RS. Early cd30 signaling is
critical for adoptively transferred cd4+cd25+ regulatory t cells in prevention of acute graft-versus-host disease.
Blood. 2007;109:2225-2233
Zeiser R, Youssef S, Baker J, Kambham N, Steinman L, Negrin RS. Preemptive hmg-coa reductase inhibition
provides graft-versus-host disease protection by th-2 polarization while sparing graft-versus-leukemia activity.
Blood. 2007;110:4588-4598
Zeiser R, Zambricki EA, Leveson-Gower D, Kambham N, Beilhack A, Negrin RS. Host-derived interleukin-18
differentially impacts regulatory and conventional t cell expansion during acute graft-versus-host disease. Biol
Blood Marrow Transplant. 2007;13:1427-1438
Zeiser R, Zambricki EA, Leveson-Gower D, Kambham N, Beilhack A, Negrin RS. Host derived interleukin-18
differentially impacts regulatory and conventional t cell expansion during acute graft-versus-host disease.
Biology of Blood and Marrow Transplantation. 2007;13:1427-1438
Zeng L, Kizaka Kondoh S, Itasaka S, Xie X, Inoue M, Tanimoto K, Shibuya K, Hiraoka M. Hypoxia inducible factor
1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions. Cancer
science. 2007;98:1394-1401
Zeng L, Ou G, Itasaka S, Harada H, Xie X, Shibuya K, Kizaka-Kondoh S, Morinibu A, Shinomiya K, Hiraoka M.
Ts-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation
and inducing endothelial cell apoptosis. Cancer Sci. 2008;99:2327-2335
Zeng L, Zou C, Xie X, Kizaka-Kondoh S, Hiraoka M, Guo G. Effects of paclitaxel on human lung cancer cell lines
in vitro and in vivo. 7th Asian-Pacific Conference on Medical and Biological Engineering. 2008:518-523
Zeng Z, Xi Shi Y, Samudio IJ, Wang RY, Ling X, Frolova O, Levis M, Rubin JB, Negrin RR, Estey EH, Konoplev S,
Andreeff M, Konopleva M. Targeting the leukemia microenvironment by cxcr4 inhibition overcomes resistance
to kinase inhibitors and chemotherapy in aml. Blood. 2009;113:6215-6224
Zepp M, Armbruster FP, Berger MR. Treatment with a rat monoclonal antibody against the sibling protein bone
sialoprotein ii is effective against osteolytic lesions in nude rats caused by mda-mb-231 breast cancer cells.
Proceedings of the American Association for Cancer Research Annual Meeting. 2009;50:299
Zhang B, Halder SK, Zhang S, Datta PK. Targeting transforming growth factor-β signaling in liver metastasis of
colon cancer. Cancer Letters. 2009;277:114-120
Zhang C, Gao S, Jiang W, Lin S, Du F, Li Z, Huang W. Targeted minicircle DNA delivery using folate-poly
(ethylene glycol)-polyethylenimine as non-viral carrier. Biomaterials. 2010;31:6075-6086
Zhang C, Lou J, Li N, Todorov I, Lin C, Cao Y, Contag C, Kandeel F, Forman S, Zeng D. Donor cd8+ t cells mediate
graft-versus-leukemia activity without clinical signs of graft-versus-host disease in recipients conditioned with
anti-cd3 monoclonal antibody. The Journal of Immunology. 2007;178:838
Zhang C, Yan Z, Arango ME, Painter CL, Anderes K. Advancing bioluminescence imaging technology for the
evaluation of anticancer agents in the mda-mb-435-hal-luc mammary fat pad and subrenal capsule tumor models.
Clin Cancer Res. 2009;15:238-246
Zhang D, LaFortune TA, Krishnamurthy S, Esteva FJ, Cristofanilli M, Liu P, Lucci A, Singh B, Hung MC,
Hortobagyi GN, Ueno NT. Egfr tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and
inhibits metastasis in inflammatory breast cancer. Clinical Cancer Research. 2009;15:6639-6648
Zhang G, Williams Jr D, Bednar B, Chen T, Hargreaves R, Sur C. Evaluation of antitumor activity of anti-cancer
drugs with bioluminescent imaging of hollow fibers. Proceedings of the American Association for Cancer
Research. 2006;2006:233
Zhang GJ, Chen TB, Bednar B, Connolly BM, Hargreaves R, Sur C, Williams DL. Optical imaging of tumor cells in
hollow fibers: Evaluation of the antitumor activities of anticancer drugs and target validation. Neoplasia.
2007;9:652-661
Zhang GJ, Chen TB, Hargreaves R, Sur C, Williams DL, Jr. Bioluminescence imaging of hollow fibers in living
animals: Its application in monitoring molecular pathways. Nat Protoc. 2008;3:891-899
Zhang GJ, Kaelin WGJ. Bioluminescent imaging of ubiquitin ligase activity: Measuring cdk2 activity in vivo
through changes in p27 turnover. Methods in Enzymology. 2005;399:530-549
Zhang GJ, Safran M, Wei W, Sorensen E, Lassota P, Zhelev N, Neuberg DS, Shapiro G, Kaelin WG, Jr.
Bioluminescent imaging of cdk2 inhibition in vivo. Nat Med. 2004;10:643-648
Zhang H, Fagan DH, Zeng X, Freeman KT, Sachdev D, Yee D. Inhibition of cancer cell proliferation and metastasis
2912.
2913.
2914.
2915.
2916.
2917.
2918.
2919.
2920.
2921.
2922.
2923.
2924.
2925.
2926.
2927.
2928.
2929.
2930.
2931.
2932.
2933.
2934.
2935.
2936.
by insulin receptor downregulation. Oncogene. 2010
ZHANG H, KALKERI G, MANI N, GROSSMAN T. Development and validation of a multi-dose neutropenic rat
thigh infection model using real-time monitoring of staphylococcus aureus growth in vivo. In Vivo.
2008;22:667
Zhang H, Morgan D, Cecil G, Burkholder A, Ramocki N, Scull B, Lund PK. Biochromoendoscopy: Molecular
imaging with capsule endoscopy for detection of adenomas of the gi tract. Gastrointest Endosc. 2008
Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza
GL. Digoxin and other cardiac glycosides inhibit hif-1α synthesis and block tumor growth. Proceedings of the
National Academy of Sciences of the United States of America. 2008;105:19579-19586
Zhang H, Qiao H, Bakken A, Gao F, Huang B, Liu YY, El-Deiry W, Ferrari VA, Zhou R. Utility of dual-modality
bioluminescence and mri in monitoring stem cell survival and impact on post myocardial infarct remodeling.
Academic radiology. 2011;18:3-12
Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP. Regulation of cellular growth by the drosophila target of
rapamycin dtor. Genes and Development. 2000;14:2712-2724
Zhang H, Wu X, Wang H, Mikheev AM, Mao Q, Unadkat JD. Effect of pregnancy on cytochrome p450 3a and pglycoprotein expression and activity in the mouse: Mechanisms, tissue specificity, and time course. Molecular
Pharmacology. 2008;74:714-723
Zhang HY, Man JH, Liang B, Zhou T, Wang CH, Li T, Li HY, Li WH, Jin BF, Zhang PJ, Zhao J, Pan X, He K, Gong
WL, Zhang XM, Li AL. Tumor-targeted delivery of biologically active trail protein. Cancer Gene Ther. 2010
Zhang J, Adrian FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, Sim T, Powers J, Dierks C, Sun F, Guo GR, Ding
Q, Okram B, Choi Y, Wojciechowski A, Deng X, Liu G, Fendrich G, Strauss A, Vajpai N, Grzesiek S, Tuntland T, Liu
Y, Bursulaya B, Azam M, Manley PW, Engen JR, Daley GQ, Warmuth M, Gray NS. Targeting bcr-abl by combining
allosteric with atp-binding-site inhibitors. Nature. 2010;463:501-506
Zhang J, Dai J, Lu Y, Yao Z, O'Brien CA, Murtha JM, Qi W, Hall DE, Manolagas SC, Ershler WB, Keller ET. In vivo
visualization of aging-associated gene transcription: Evidence for free radical theory of aging. Exp Gerontol.
2004;39:239-247
Zhang J, He J, Chen YM, Wang JH, Ma YY. Morphine and propranolol co-administration impair consolidation of
y-maze spatial recognition memory. Brain Res. 2008
Zhang J, Lu Y, Dai J, Yao Z, Kitazawa R, Kitazawa S, Zhao X, Hall DE, Pienta KJ, Keller ET. In vivo real-time
imaging of tgf-beta-induced transcriptional activation of the rank ligand gene promoter in intraosseous prostate
cancer. Prostate. 2004;59:360-369
Zhang J, Rubio V, Lieberman MW, Shi ZZ. Ola1, an obg-like atpase, suppresses antioxidant response via
nontranscriptional mechanisms. Proceedings of the National Academy of Sciences of the United States of
America. 2009;106:15356-15361
Zhang J, Rubio V, Zheng S, Shi Z. Knockdown of ola1, a regulator of oxidative stress response, inhibits motility
and invasion of breast cancer cells*. J Zhejiang Univ Sci B. 2009;10:796-804
Zhang J, Tu Q, Chen J. Applications of transgenics in studies of bone sialoprotein. Journal of Cellular
Physiology. 2009;220:30-34
Zhang J, Wang C, Ke N, Bliesath J, Chionis J, He QS, Li Q, Chatterton JE, Wong-staal F, Zhou D. A more efficient
rnai inducible system for tight regulation of gene expression in mammalian cells and xenograft animals. RNA.
2007;13:1375-1383
Zhang J, Zhao D, Park HK, Wang H, Dyer RB, Liu W, Klee GG, McNiven MA, Tindall DJ, Molina JR, Fei P. Favl
elevation in human tumors disrupts fanconi anemia pathway signaling and promotes genomic instability and
tumor growth. Journal of Clinical Investigation. 2010;120:1524-1534
Zhang KX, Moussavi M, Kim C, Chow E, Chen IS, Fazli L, Jia W, Rennie PS. Lentiviruses with trastuzumab bound
to their envelopes can target and kill prostate cancer cells. Cancer Gene Ther. 2009
Zhang L, Alizadeh D, Van Handel M, Kortylewski M, Yu H, Badie B. Stat3 inhibition activates tumor macrophages
and abrogates glioma growth in mice. Glia. 2009;57:1458-1467
Zhang L, Bhojani MS, Ross BD, Rehemtulla A. Enhancing akt imaging through targeted reporter expression. Mol
Imaging. 2008;7:168-174
Zhang L, Bibee K, Zhang H, Chen J, Allen J, Lanza GM, Wickline SA. Quantitative molecular imaging of
atherosclerotic aortic endothelial dysfunction with perfluorocarbon (f-19) nanoparticle magnetic resonance
imaging and spectroscopy. Circulation. 2009;120:S366
Zhang L, Johnson M, Le KH, Sato M, Ilagan R, Iyer M, Gambhir SS, Wu L, Carey M. Interrogating androgen
receptor function in recurrent prostate cancer. Cancer Res. 2003;63:4552-4560
Zhang L, Virani S, Zhang Y, Bhojani MS, Burgess TL, Coxon A, Galban CJ, Ross BD, Rehemtulla A. Molecular
imaging of c-met tyrosine kinase activity. Analytical biochemistry. 2011;412:1-8
Zhang N, Ahsan MH, Purchio AF, West DB. Serum amyloid a-luciferase transgenic mice: Response to sepsis, acute
arthritis, and contact hypersensitivity and the effects of proteasome inhibition. Journal of Immunology.
2005;174:8125-8134
Zhang N, Ahsan MH, Zhu L, Sambucetti LC, Purchio AF, West DB. Nf-kappab and not the mapk signaling pathway
regulates gadd45beta expression during acute inflammation. Journal of Biological Chemistry.
2005;280:21400-21408
Zhang N, Ahsan MH, Zhu L, Sambucetti LC, Purchio AF, West DB. Regulation of ikappabalpha expression
2937.
2938.
2939.
2940.
2941.
2942.
2943.
2944.
2945.
2946.
2947.
2948.
2949.
2950.
2951.
2952.
2953.
2954.
2955.
2956.
2957.
2958.
2959.
2960.
2961.
involves both nf-kappab and the map kinase signaling pathways. J Inflamm (Lond). 2005;2:10
Zhang N, Fang Z, Contag PR, Purchio AF, West DB. Tracking angiogenesis induced by skin wounding and
contact hypersensitivity using a vegfr2-luciferase transgenic mouse. Blood. 2004;103:617-626
Zhang N, Li BH, Weber A, Sambucetti LC, Purchio T. In vivo monitoring of vegf expression in primary and
metastatic tumors with ivistm (in vivo imaging system). Proceedings of the American Association for Cancer
Research Annual Meeting. 2001;42:721-722
Zhang N, Lyons S, Lim E, Lassota P. A spontaneous acinar cell carcinoma model for monitoring progression of
pancreatic lesions and response to treatment through noninvasive bioluminescence imaging. Clin Cancer Res.
2009;15:4915-4924
Zhang N, Weber A, Li B, Lyons R, Contag PR, Purchio AF, West DB. An inducible nitric oxide synthase-luciferase
reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice. Journal of Immunology.
2003;170:6307-6319
Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M,
Richardson AL, Hahn WC, Kaelin WG, Bommi-Reddy A. Control of cyclin d1 and breast tumorigenesis by the
egln2 prolyl hydroxylase. Cancer Cell. 2009;16:413-424
Zhang S, Liu G, Liu X, He J, Rusckowski M, Hnatowich D. Initial in vitro and mouse in vivo studies of
fluorescence resonance energy transfer and optical imaging by oligomer hybridization. J Nucl Med.
2006;47:516P
Zhang S, Liu G, Liu X, Yin D, Dou S, He J, Rusckowski M, Hnatowich DJ. Comparison of several linear
fluorophore- and quencher-conjugated oligomer duplexes for stability, fluorescence quenching, and kinetics in
vitro and in vivo in mice. Bioconjug Chem. 2007;18:1170-1175
Zhang W, Contag PR, Hardy J, Zhao H, Vreman HJ, Hajdena-Dawson M, Wong RJ, Stevenson DK, Contag CH.
Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-1.
Journal of Molecular Medicine. 2002;80:655-664
Zhang W, Contag PR, Madan A, Stevenson DK, Contag CH. Bioluminescence for biological sensing in living
mammals. Adv Exp Med Biol. 1999;471:775-784
Zhang W, Feng JQ, Harris SE, Contag PR, Stevenson DK, Contag CH. Rapid in vivo functional analysis of
transgenes in mice using whole body imaging of luciferase expression. Transgenic Research. 2001;10:423-434
Zhang W, Konopleva M, Shi YX, McQueen T, Harris D, Ling X, Estrov Z, Quintas-Cardama A, Small D, Cortes J,
Andreeff M. Mutant flt3: A direct target of sorafenib in acute myelogenous leukemia. J Natl Cancer Inst.
2008;100:184-198
Zhang W, Moorthy B, Chen M, Muthiah K, Coffee R, Purchio AF, West DB. A cyp1a2-luciferase transgenic cd-1
mouse model: Responses to aryl hydrocarbons similar to the humanized ahr mice. Toxicological Sciences.
2004;82:297-307
Zhang W, Purchio A, Chen K, Burns SM, Contag CH, Contag PR. In vivo activation of the human cyp3a4
promoter in mouse liver and regulation by pregnane x receptors. Biochemical Pharmacology.
2003;65:1889-1896
Zhang W, Purchio AF, Chen K, Wu J, Lu L, Coffee R, Contag PR, West DB. A transgenic mouse model with a
luciferase reporter for studying in vivo transcriptional regulation of the human cyp3a4 gene. Drug Metabolism
and Disposition: The Biological Fate of Chemicals. 2003;31:1054-1064
Zhang W, Purchio AF, Coffee R, West DB. Differential regulation of the human cyp3a4 promoter in transgenic
mice and rats. Drug Metabolism and Disposition: The Biological Fate of Chemicals. 2004;32:163-167
Zhang X, Peault B, Chen W, Li W, Corselli M, James AW, Lee M, Siu RK, Shen P, Zheng Z, Shen J, Kwak J, Zara JN,
Chen F, Zhang H, Yin Z, Wu B, Ting K, Soo C. The nell-1 growth factor stimulates bone formation by purified
human perivascular cells. Tissue engineering. Part A. 2011
Zhang Y, Bradshaw Pierce E, DeLille A, Gustafson D, Anchordoquy T. In vivo comparative study of lipid/DNA
complexes with different in vitro serum stability: Effects on biodistribution and tumor accumulation. Journal of
Pharmaceutical Sciences. 2008;97:237-250
Zhang Y, Bressler J, Neal J, Lal B, Bhang H, Laterra J, Pomper M. Abcg2/bcrp expression modulates d-luciferin–
based bioluminescence imaging. Cancer Res. 2007;67:9389
Zhang Y, Byun Y, Ren YR, Liu JO, Laterra J, Pomper MG. Identification of inhibitors of abcg2 by a
bioluminescence imaging-based high-throughput assay. Cancer Res. 2009;69:5867-5875
Zhang Y, Laterra J, Pomper MG. Hedgehog pathway inhibitor hhantag691 is a potent inhibitor of abcg2/bcrp and
abcb1/pgp1. Neoplasia. 2009;11:96-101
Zhang Y, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, Hexner E, Frank DM,
Emerson SG, Pear WS, Maillard I. Notch signaling is a critical regulator of allogeneic cd4+ t-cell responses
mediating graft-versus-host disease. Blood. 2011;117:299-308
Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, Wang L. Nuclear receptor shp, a death receptor that
targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol. 2010;30:1341-1356
Zhang YQ, Tsai YC, Monie A, Wu TC, Hung CF. Enhancing the therapeutic effect against ovarian cancer through a
combination of viral oncolysis and antigen-specific immunotherapy. Mol Ther. 2010
Zhang Z, Chen X, Lu Y, Xiu J, Kaufman D, Fryer J. Effect of nf-kb activtion in the altered small bowel epethelial
permeability following ischemia/reperfusion injury. Transplantation. 2006;82:367
Zhang Z, Huang Y, Zhu H. A highly efficient protocol of generating and analyzing vzv orf deletion mutants based
2962.
2963.
2964.
2965.
2966.
2967.
2968.
2969.
2970.
2971.
2972.
2973.
2974.
2975.
2976.
2977.
2978.
2979.
2980.
2981.
2982.
2983.
2984.
2985.
2986.
on a newly developed luciferase vzv bac system. Journal of Virological Methods. 2008;148:197-204
Zhang Z, Huang Y, Zhu H. An efficient protocol for vzv bac-based mutagenesis. In vitro mutagenesis protocols.
2010:75-86.
Zhang Z, Rowe J, Wang W, Sommer M, Arvin A, Moffat J, Zhu H. Genetic analysis of varicella-zoster virus orf0 to
orf4 by use of a novel luciferase bacterial artificial chromosome system. J Virol. 2007;81:9024-9033
Zhang Z, Winborn C, Marquez de Prado B, Russo A. Sensitization of calcitonin gene-related peptide receptors by
receptor activity-modifying protein-1 in the trigeminal ganglion. Journal of Neuroscience. 2007;27:2693
Zhang ZJ, Chen X, Lu Y, Chen K, Xu J, Clayburgh DR, Turner JR, Kaufman D, Barrett T, Fryer JP. Role of nf kappa
b activation in altered small bowel epithelial permeability following ischemia/reperfusion injury.
Gastroenterology. 2007;132:A565
Zhao D, Alizadeh D, Zhang L, Liu W, Farrukh O, Manuel E, Diamond DJ, Badie B. Carbon nanotubes enhance cpg
uptake and potentiate antiglioma immunity. Clinical cancer research : an official journal of the American
Association for Cancer Research. 2011;17:771-782
Zhao D, Najbauer J, Garcia E, Metz MZ, Glackin CA, Kim SU, Aboody KS. Novel neural stem cell-mediated tumor
selective gene therapy for breast cancer metastases. Molecular Therapy. 2009;17:S137
Zhao H, Doyle T, Coquoz O, Kalish F, Rice B, Contag C. Emission spectra of bioluminescent reporters and
interaction with mammalian tissue determine the sensitivity of detection in vivo. Journal of biomedical optics.
2005;10:041210
Zhao H, Doyle TC, Wong RJ, Cao Y, Stevenson DK, Piwnica-Worms D, Contag CH. Characterization of
coelenterazine analogs for measurements of renilla luciferase activity in live cells and living animals. Mol
Imaging. 2004;3:43-54
Zhao H, Tang C, Cui K, Ang BT, Wong ST. A screening platform for glioma growth and invasion using
bioluminescence imaging. J Neurosurg. 2009
ZHAO H, WONG R, NGUYEN X, KALISH F, MIZOBUCHI M, VREMAN H, STEVENSON D, CONTAG C. Expression
and regulation of heme oxygenase isozymes in the developing mouse cortex. Pediatric Research. 2006;60:518
Zhao H, Zhu J, Cui K, Xu X, O'Brien M, Wong KK, Kesari S, Xia W, Wong ST. Bioluminescence imaging reveals
inhibition of tumor cell proliferation by alzheimer's amyloid beta protein. Cancer Cell Int. 2009;9:15
Zhao X, Kim J, Cezar CA, Huebsch N, Lee K, Bouhadir K, Mooney DJ. Active scaffolds for on-demand drug and
cell delivery. Proceedings of the National Academy of Sciences of the United States of America. 2011;108:67-72
Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, Delgado-Vargas M, Ponpuak M, Green KG,
Schmidt RE, Mizushima N, Deretic V, Sibley LD, Virgin HW. Atg5 is essential for cellular immunity in vivo and
recruitment of a p47 gtpase to the toxoplasma gondii parasitophorous vacuole in macrophages. Cell Host
Microbe. 2008;4:458-469
Zhaoa S, Stevensona D, Contaga C. The potential salmonella aroa–vaccine strain is safe and effective in young
balb/c mice. Neonatology. 2007;91:114-120
Zhen Zhang, Selariu A, Warden C, Huang G, Huang Y, Zaccheus O, Cheng T, Xia N, Zhu H. Genome-wide
mutagenesis reveals that orf7 is a novel vzv skin-tropic factor. PLoS Pathogens. 2010
Zheng C, Shinomiya T, Goldsmith C, Di Pasquale G, Baum B. Convenient and reproducible in vivo gene transfer
to mouse parotid glands. Oral Diseases. 2010
Zheng G, Chen J, Stefflova K, Jarvi M, Li H, Wilson BC. Photodynamic molecular beacon as an activatable
photosensitizer based on protease-controlled singlet oxygen quenching and activation. Proceedings of the
National Academy of Sciences of the United States of America. 2007;104:8989-8994
Zheng J, Xu L, Zhou H, Zhang W, Chen Z. Quantitative analysis of cell tracing by in vivo imaging system.
Journal of Huazhong University of Science and Technology--Medical Sciences--. 2010;30:541-545
Zheng W, Watts L, Holstein D, Prajapati S, Keller C, Grass E, Walter C, Lechleiter J. Purinergic receptor
stimulation reduces cytotoxic edema and brain infarcts in mouse induced by photothrombosis by energizing
glial mitochondria PLoS ONE. 2010
Zhou H, Luby-Phelps K, Mickey BE, Habib AA, Mason RP, Zhao D. Dynamic near-infrared optical imaging of 2deoxyglucose uptake by intracranial glioma of athymic mice. PLoS One. 2009;4
Zhou P, Lessa N, Estrada DC, Severson EB, Lingala S, Zern MA, Nolta JA, Wu J. Decellularized liver matrix as a
carrier for the transplantation of human fetal and primary hepatocytes in mice. Liver transplantation : official
publication of the American Association for the Study of Liver Diseases and the International Liver
Transplantation Society. 2011;17:418-427
Zhou Q, Bucher C, Munger ME, Highfill SL, Tolar J, Munn DH, Levine BL, Riddle M, June CH, Vallera DA, Weigel
BJ, Blazar BR. Depletion of endogenous tumor-associated regulatory t cells improves the efficacy of adoptive
cytotoxic t-cell immunotherapy in murine acute myeloid leukemia. Blood. 2009;114:3793-3802
Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC,
Kuchroo VK, Blazar BR. Coexpression of tim-3 and pd-1 identifies a cd8+ t-cell exhaustion phenotype in mice
with disseminated acute myelogenous leukemia. Blood. 2011;117:4501-4510
Zhu H, Woolfenden S, Bronson R, Jaffer Z, Barluenga S, Winssinger N, Rubenstein A, Chen R, Charest A. The
novel hsp90 inhibitor nxd30001 induces tumor regression in a genetically engineered mouse model of
glioblastoma multiforme. Mol Cancer Ther. 2010;9:2618
Zhu Q, Oei Y, Mendel DB, Garrett EN, Patawaran MB, Hollenbach PW, Aukerman SL, Weiner AJ. Novel robust
hepatitis c virus mouse efficacy model. Antimicrobial Agents and Chemotherapy. 2006;50:3260-3268
2987.
2988.
2989.
2990.
2991.
2992.
2993.
2994.
2995.
2996.
2997.
2998.
2999.
3000.
3001.
3002.
Zhu Q, Weiner AJ. A hepatitis c virus xenograft mouse efficacy model. Inflammation and cancer. 2008:323-331.
Ziegler DS, Wright RD, Kesari S, Lemieux ME, Tran MA, Jain M, Zawel L, Kung AL. Resistance of human
glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis
proteins. Journal of Clinical Investigation. 2008;118:3109-3122
Ziegler L, Yang L, Joo K, Yang H, Baltimore D, Wang P. Targeting lentiviral vectors to antigen-specific
immunoglobulins. Human Gene Therapy. 2008;19:861-872
Ziegler SA, Nuckols J, McGee CE, Huang YJ, Vanlandingham DL, Tesh RB, Higgs S. In vivo imaging of
chikungunya virus in mice and aedes mosquitoes using a renilla luciferase clone. Vector Borne Zoonotic Dis.
2011
Zincarelli C, Soltys S, Rengo G, Rabinowitz JE. Analysis of aav serotypes 1-9 mediated gene expression and
tropism in mice after systemic injection. Mol Ther. 2008;16:1073-1080
Zinn K, Wu H, Stargel A, Adams A, Chaudhuri T. A genetic strategy to inhibit complement activation arising from
adenoviral vectors. Molecular Therapy. 2005;11:S173-S174
Zinn KR, Chaudhuri TR, Szafran AA, O’Quinn D, Weaver C, Dugger K, Lamar D, Kesterson RA, Wang X, Frank SJ.
Noninvasive bioluminescence imaging in small animals. ILAR J. 2008;49:103-115
Zinn KR, Szalai AJ, Stargel A, Krasnykh V, Chaudhuri TR. Bioluminescence imaging reveals a significant role for
complement in liver transduction following intravenous delivery of adenovirus. Gene Ther. 2004;11:1482-1486
Zinonos I, Labrinidis A, Lee M, Liapis V, Hay S, Ponomarev V, Diamond P, Findlay DM, Zannettino AC, Evdokiou
A. Anticancer efficacy of apo2l/trail is retained in the presence of high and biologically active concentrations of
osteoprotegerin in vivo. Journal of bone and mineral research : the official journal of the American Society for
Bone and Mineral Research. 2011;26:630-643
Zinonos I, Labrinidis A, Lee M, Liapis V, Hay S, Ponomarev V, Diamond P, Zannettino AC, Findlay DM, Evdokiou
A. Apomab, a fully human agonistic antibody to dr5, exhibits potent antitumor activity against primary and
metastatic breast cancer. Mol Cancer Ther. 2009;8:2969-2980
Zisch AH, Ehrbar M, Hubbell J, Raeber G, Schnell C, Walpoth B. Biomimetic materials for injectable tissue
engineering: Studies of acute, lasting and unexpected angiogenesis response. FASEB Journal. 2006;20:A20-A21
Zolochevska O, Figueiredo ML. Expression of cell cycle regulator cdk2ap1 suppresses tumor cell phenotype by
non-cell autonomous mechanisms. Oral Oncology. 2009;45:e106-112
Zou P, Xu S, Wang A, Povoski S, Johnson M, Martin E, Subramaniam V, Schlom J, Xu R, Sun D. Near-infrared
fluorescence labeled anti-tag-72 monoclonal antibodies for tumor imaging in colorectal cancer xenograft mice.
Mol Pharm. 2009
Zoubeidi A, Zardan A, Beraldi E, Fazli L, Sowery R, Rennie P, Nelson C, Gleave M. Cooperative interactions
between androgen receptor (ar) and heat-shock protein 27 facilitate ar transcriptional activity. Cancer Res.
2007;67:10455
Zugates G, Peng W, Zumbuehl A, Jhunjhunwala S, Huang Y, Langer R, Sawicki J, Anderson D. Rapid optimization
of gene delivery by parallel end-modification of poly ( -amino ester) s. Molecular Therapy. 2007;15:1306-1312
Zukerberg LR, DeBernardo RL, Kirley SD, D'Apuzzo M, Lynch MP, Littell RD, Duska LR, Boring L, Rueda BR.
Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial
hyperplasia and endometrial cancer. Cancer Res. 2004;64:202-208