lIFE SCIEnCE TECHnoloGICAl CoRE FACIlITIES

Transcription

lIFE SCIEnCE TECHnoloGICAl CoRE FACIlITIES
2012
1
ShareBiotech is a European project aimed at
strengthening the development of a knowledgebased bioeconomy in several Atlantic Area regions
where life sciences and biotechnology are a
promising sector for regional development.
Crédit photo : DNAmicroarrays-Biocant
This booklet gathers high-profile technological core
facilities*(TCF) located in Ireland, France, Spain and
Portugal and open to external users. The objective of
ShareBiotech is to improve and promote access to such
facilities in order to support research and innovation in
life sciences and biotechnology.
There is currently a movement within the European
Union towards an improved organization of life science
research facilities and infrastructures (ESFRI Roadmap,
FP7, Horizon 2020), which today tend to be fragmented
and multisited. The challenge is to ensure cohesion and
integration to attain a critical mass.
ShareBiotech gathers 10
partners from 7 regions
from Ireland, France, Spain
and Portugal.
This 3-year project was
launched in early 2010
and is co-financed with the
support of the European
Union ERDF –
Atlantic Area programme.
Given its dimension, if R&D in the Atlantic Area is
to become competitive and a driver for economic
development, accessibility to and networking of
existing mid-size technological core facilities, as well
as infrastructure sharing, need to be a priority. The
ShareBiotech project has strived to meet this challenge
by the creation of a network of TCF accessible to
researchers from both the public and the private
sectors.
We invite you to discover now the technology
resources available in the seven regions involved in the
ShareBiotech project!
The ShareBiotech partners
* Technological Core Facilities are defined as a set of equipment and associated
expertise, which operating capacity is available to public or private organizations,
with a view to offering access to high-level technologies for R&D.
ARRonAX
oTHER
BIoInFoRmATICS
nAnoBIoTECHnoloGy
PRoCESS BIoTECHnoloGy
TECHnIQUES
ImAGInG
BIoloGICAl RESoURCES
AnD ASSoCIATED FACIlITIES
GEnE AnD RnA vECToRS
CEll/TISSUE CUlTURE
AnD EnGInEERInG
PRoTEInS AnD oTHER
molECUlES
TECHnoloGICAl CoRE FACIlITIES
DnA/RnA
TECHnoloGIES
Pages
9
BIBS
10
BIoDImAR
11
BIoGEnoUEST GEnomICS
12
THERASSAy
13
CoRSAIRE
14
H2P2
15
ImPACCEll
16
ImPACT
17
mICRoPICEll
18
molECUlAR CyToGEnETICS PlATFoRm
19
mRIC
20
nEURInFo
21
onIS
22
PRISm
23
PRoDIABIo
24
BIoGEnoUEST PRoTEomICS
25
RAT TRAnSGEnESIS FACIlITy
26
REnABI-Go
27
SynnAnovECT
28
vIRAl vECToRS AnD GEnE TRAnSFER FACIlITy
29
XEnoPUS TRAnSGEnESIS FACIlITy
30
AGRIvAl
31
AGRoBIo
32
AlGEnICS
33
ATlAnCHIm PHARmA
34
ATlAnTIC BonE SCREEn
35
BIoFoRTIS SAS
36
BIoPREDIC InTERnATIonAl
37
BIoTRIAl
38
C.RIS PHARmA
39
CARlInA TECHnoloGIES
40
CEvA
41
ClEAn CEllS
42
HITEX
43
HPC PHARmA
44
ID.mER
45
In-CEll-ART
46
myElomAX
47
PolymARIS BIoTECHnoloGy
48
vEGEnov
49
vIvAlIS SA
50
PRoTEomICS AnD mASS SPECTRomETRy
CoRE FACIlITy
52
EXPRESSIon FACToRy FACIlITy
53
ConWAy mASS SPECTRomETRy RESoURCE &
PRoTEInS SEPARATIonS lABoRAToRy
54
oTHER
BIoInFoRmATICS
nAnoBIoTECHnoloGy
TECHnIQUES
ImAGInG
CEll/TISSUE CUlTURE
AnD EnGInEERInG
PRoTEInS AnD oTHER
molECUlES
DnA/RnA
TECHnoloGIES
Pages
PHoTonICS RESEARCH lABoRAToRy, CRAnn
55
BIoloGICAl nUClEAR mAGnETIC RESonAnCE
56
mETABolomICS FACIlITy, UCD InSTITUTE oF
FooD AnD HEAlTH
57
mR ComPATIBlE ElECTRoEnCEPHAloGRAPHy SySTEm lABoRAToRy
58
PEPTIDE SynTHESIS lABoRAToRy, RCSI
59
ConFoCAl mICRoSCoPy FACIlITy, TRInITy
CollEGE InSTITUTE oF nEURoSCIEnCE
60
mASS SPECTRomETRy RESoURCE AnD PRoTEInS SEPARATIonS lABoRAToRy
61
TRInITy CEnTRE FoR HIGH PERFoRmAnCE
ComPUTInG
62
ComPUTATIonAl mATERIAlS DESIGn, TynDAll nATIonAl InSTITUTE
63
TRInITy GEnomE SEQUEnCInG lABoRAToRy,
InSTITUTE oF molECUlAR mEDICInE,
64
mICRoARRAy PRoFIlInG CoRE FACIlITy, nICB
65
IllUmInA GEnomE AnAlyZER SEQUEnCInG
PlATFoRm, ConWAy InSTITUTE
66
GEnoTyPInG lABoRAToRy
67
AFFymETRIX GEnECHIP TECHnoloGy PlATFoRm, ConWAy InSTITUTE
68
InSTITUTE oF molECUlAR mEDICInE FloW
CyTomETRy FACIlITy
69
FloW CyTomETRy CoRE TECHnoloGy
70
CEll CHARACTERISATIon FACIlITy, nCIB
71
nATIonAl ComPUTATIonAl DRUG DESIGn
72
mATHEmATICS APPlICATIonS ConSoRTIUm
FoR SCIEnCE AnD InDUSTRy
73
ZEBRAFISH FACIlITy
74
UCD CEnTRE FoR lIvE CEll ImAGInG
75
TWo-PHoTon AnD ConvEnTIonAl ConFoCAl ImAGInG lABoRAToRy
76
nATIonAl BIoPHoTonICS AnD ImAGInG
PlATFoRm
77
nAnoSCAlE FUnCTIon GRoUP ATomIC
FoRCE mICRoSCoPy lABoRAToRy
78
HIGH RESolUTIon ElECTRon mICRoSCoPy
CEnTRE
79
HIGH ConTEnT SCREEnInG FACIlITy
CRAnn mICRoSCoPy CEnTRE, UnIT 27, TRInITy EnTERPRISE AnD InnovATIon CEnTRE,
80
81
ConFoCAl lASER SCAnnInG mICRoSCoPy
FACIlITy
82
APERIo DIGITAl SlIDE SCAnnInG FACIlITy
83
ADvAnCED mICRoSCoPy RESEARCH
FACIlITy
84
BIonAno lABoRAToRy, CRAnn
85
BIoInFoRmATICS CoRE FACIlITy
86
CEnTRE FoR RESEARCH on ADAPTIvE nAnoSTRUCTURES AnD nAnoDEvICES
87
nATIonAl InSTITUTE FoR CEllUlAR BIoTECHnoloGy
88
ConWAy InSTITUTE oF BIomolECUlAR
AnD BIomEDICAl RESEARCH
89
nATIonAl InSTITUTE FoR BIoPRoCESSInG
RESEARCH & TRAInInG
CEnTRE FoR BIoPolymER & BIomolECUlAR RESEARCH
CEnTRE FoR ADvAnCED mEDICAl ImAGInG,
ST. JAmES
TynDAll nATIonAl InSTITUTE
AlImEnTARy PHARmABIoTIC CEnTRE
mARInE BIoTECHnoloGy CEnTRE
AlImEnTARy GlyCoSCIEnCE RESEARCH Cl.
molECUlAR DIAGnoSTICS RESEARCH
GRoUP, nUIG
nATIonAl CEnTRE FoR BIomEDICAl EnGInEERInG SCIEnCE
nETWoRK oF EXCEllEnCE FoR FUnCTIonAl BIomATERIAlS, nUIG
CEnTRE FoR CEll mAnUFACTURInG, nUIG
SHAnnon APPlIED BIoTECH. CEnTRE
mICRoARRAyS
BIoInFoRmATICS
molECUlAR BIoTECHnoloGy
mASS SPECTRomETRy / PRoTEomICS
CEll CUlTURE
DnA GEnoTyPInG
ADvAnCED SEQUEnCInG SERvICE
ElISA & mUlTIPlEX
FooD SCIEnCE AnD BIoCHEmISTRy
lABoRAToRy FoR HIGH-RESolUTIon CEll
BIo-ImAGInG
STRUCTURAl AnD ComPUTATIonAl BIoloGy lABoRAToRy
BlUEWoRKS
ImAR
CIEnGIS - SISTEmAS DE ConTRolo AvAnçADo, SA
lABoRAToRy FoR ADvAnCED ComPUTInG
oF THE UnIvERSITy oF CoImBRA
lABoRAToRy FoR BIoSTATISTICS AnD mEDICAl InFoRmATICS
SICGEn AnTIBoDIES
CCmAR
CIImAR
CBmE/UAlG AnImAl FACIlITy
CEBAl
RESEARCH CEnTRE FoR FooD TECHno-CITA
SAnITARy EnGInEERInG lABoRAToRy
FIDEnA
mUCoSAl DRUG/AnTIGEn DElIvERy - UnAv
CnTA
CEnER
ESTnA
GERmPlASm BAnK SERvICE. IDEn BIo.
DAIRy InSTITUTE, Ill
PRoTEo., GEno. AnD BIoInFoRmATICS-CImA
BIoFIlTR. FoR oDoUR REmovAl, FIDImA
FloW CITomETRy, nAvARRABIomED
GEnomICS UnIT, nAvARRABIomED
PRoTEomICS UnIT, nAvARRABIomED
BIoBAnK, nAvARRABIomED
ToXIColoGy UnIT, CIFA-UnAv
nASERTIC lABoRAToRy UnIT
oTHER
BIoInFoRmATICS
nAnoBIoTECHnoloGy
TECHnIQUES
ImAGInG
CEll/TISSUE CUlTURE
AnD EnGInEERInG
PRoTEInS AnD oTHER
molECUlES
DnA/RnA
TECHnoloGIES
Pages
90
91
92
93
94
95
96
97
98
99
100
101
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120 -121
122
123
124
125
126
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
Key technologies
(adapted from oECD categories) :
market Applications
These icons represent the different business
sectors
DNA/RNA
GEnomICS, PHARmACoGEnomICS, GEnE PRoBES, GEnETIC
EnGInEERInG, DnA/RnA SEQUEnCInG/SynTHESIS/AmPlIFICATIon,
GEnE EXPRESSIon PRoFIlInG, AnD USE oF AnTISEnSE TECHnoloGy.
Human health
PROTEINS AND OTHER MOLECULES
SEQUEnCInG/SynTHESIS/EnGInEERInG oF PRoTEInS AnD PEPTIDES
(InClUDInG lARGE molECUlE HoRmonES); ImPRovED DElIvERy
mETHoDS FoR lARGE molECUlE DRUGS; PRoTEomICS, PRoTEIn
ISolATIon AnD PURIFICATIon, SIGnAlInG, IDEnTIFICATIon oF CEll.
CELL/TISSUE CULTURE AND ENGINEERING
Animal health
CEll/TISSUE CUlTURE, TISSUE EnGInEERInG (InClUDInG TISSUE
SCAFFolDS AnD BIomEDICAl EnGInEERInG), CEllUlAR FUSIon,
vACCInE/ImmUnE STImUlAnTS, EmBRyo mAnIPUlATIon.
GENE AND RNA VECTORS
GEnE THERAPy, vIRAl AnD SynTHETIC vECToRS,
AnImAl AnD vEGETAl TRAnSGEnESIS.
Cosmetics
BIOLOGICAL RESOURCES AND ASSOCIATED
FACILITIES
AnImAl moDElS, PlAnT moDElS, mICRo-oRGAnISmS moDElS,
HoUSInG AnD FACIlITIES FoR AnImAl EXPERImEnTATIon, HoUSInG
AnD FACIlITIES FoR PlAnT EXPERImEnTATIon, GREEnHoUSES,
ETC.), AnImAl BREEDInG, PlAnT BREEDInG, BIoloGICAl RESoURCES
CEnTRES, BAnKS, CollECTIonS, EXPERImEnTAl FARmS.
IMAGING
mAGnETIC RESonAnCE ImAGInG, ComPUTED TomoGRAPHy,
PoSITRon EmISSIon TomoGRAPHy (PET), SPECT : SInGlE
PHoTon EmISSIon, ComPUTED TomoGRAPHy, oPTICAl ImAGInG:
BIolUmInESCEnCE, oPTICAl ImAGInG: FlUoRESCEnCE, oPTICAl
ImAGInG: ConFoCAl ImAGInG, oPTICAl ImAGInG : (mUlTI)PHoTonIC
ImAGInG, ElECTRonIC mICRoSCoPy, UlTRASoUnDS, RADIoGRAPHy,
InFRA-RED ImAGInG.
PROCESS BIOTECHNOLOGY TECHNIQUES
FERmEnTATIon USInG BIoREACToRS, BIoPRoCESSInG,
BIolEACHInG, BIoPUlPInG, BIoBlEACHInG, BIoDESUlPHURISATIon,
BIoREmEDIATIon, BIoFIlTRATIon AnD PHyToREmEDIATIon.
Agriculture, animal
breeding, plant
science
Agri-food industry,
nutrition
NANOBIOTECHNOLOGY
APPlIES THE ToolS AnD PRoCESSES oF nAno/mICRoFABRICATIon
To BUIlD DEvICES FoR STUDyInG BIoSySTEmS AnD APPlICATIonS
In DRUG DElIvERy, DIAGnoSTICS.
BIOINFORMATICS and BIOSTATISTICS
ConSTRUCTIon oF DATABASES on GEnomES, PRoTEIn SEQUEnCES;
moDEllInG ComPlEX BIoloGICAl PRoCESSES,
InClUDInG SySTEmS BIoloGy
Environment
Energy
FRAnCE
ARRONAX
ARRONAX
ACCELERATOR FOR RESEARCH IN
RADIOCHEMISTRY AND ONCOLOGY AT
NANTES ATLANTIC
(BIOGENOUEST)
location
nAnTES, FRAnCE
Key words
RADIoCHEmISTRy, RADIoISoToPE,
CyCloTRon, PARTIClE ACCElERAToR,
RADIonUClIDE, RADIoBIoloGy, nUClEAR
mEDICInE, nUClEAR PHySICS
DOMAINS OF EXPERTISE AND SERVICES OFFERED
ARRonAX aims at producing innovative radionuclides for research in nuclear medicine and at performing research in radiochemistry on radiolysis.
In the field of life science, and particularly for research in nuclear medicine,
the main domain of application is diagnostic (PET imaging) and therapeutic
oncology (radionuclide therapy).
ARRonAX is unique through the association of several characteristics:
A 70 mev energy whereas the energy of the majority of biomedical
cyclotrons does not exceed 30 mev
A maximal intensity of 750 µA (2 X 375 µA) whereas the intensity of the
majority of biomedical cyclotrons does not exceed 100 µA
The possibility to accelerate protons, deutons and alpha particles whereas the majority of biomedical cyclotrons accelerates only protons.
Associated to Biogenouest, the life science technological core facilities
network in Bretagne and Pays de la loire (France), Arronax answers the
researchers’ and clinicians’ needs in nuclear physics, radiochemistry,
biology and medicine.
TECHNIQUES AND EXAMPLES OF APPLICATION
ARRonAX is located at Saint-Herblain, in the outskirts of nantes, on the
campus of the René et Guillaume laënnec university hospital and of the
René Gauducheau cancer centre.
The platform was developed in order to produce radionuclides for research in nuclear medicine:
Diagnostic: 82Sr/82Rb, 68Ge/68Ga, 64Cu, 44Sc
Dosimetry: 64Cu, 44Sc, possibly 124I, 86y
Therapy: 67Cu, 47Sc, 211At (alpha), 117mSn
moreover, a few alpha-emitting radionuclides are available, including astatine-211, lead-212/bismuth-212 and actinium-225/bismuth-213 for
nuclear physics, radiochemistry and radiobiology.
Installed over 4000 m2, ARRonAX is equipped with six beam lines ending
in six casemates, one of which is especially conceived for research experiments thanks to a vertical beam that allow numerous assays and the
production of various isotopes.
near the cyclotron, laboratories and equipment allow the conduction of
experiments in radiochemistry, radiobiology and radiolysis.
Address
CYCLOTRON ARRONAX
1, rue Arronax - CS 10112
44817 SAInT-HERBlAIn Cedex
FRAnCE
Contact detail
Renaud DEvIlDER
ACCESS PolICy
ARRonAX is built thanks to a joint initiative of Subatech laboratory (CnRS, Ecole
des mines, University of nantes) and Research Center of oncology in nantes
(Inserm, Université of nantes) for which it is a major research equipment.
But it is also open to projects originating from any interested academic research
laboratories in Europe and also, under conditions to be defined, to industrial partners. All projects will be evaluated by an international scientific committee which
will propose the priorities.
Tel. +33 (0)2 28 21 21 21
devilder@arronax-nantes.fr
www.cyclotron-nantes.fr
9
BIBS
BIOPOLYMERS, STRUCTURAL BIOLOGY
FACILITY
(BIOGENOUEST)
location
nAnTES, FRAnCE
Key words
BIoPolymERS, PolySACCHARIDES, InTERACTIonS, STRUCTURE, mASS SPECTRomETRy, nmR, mICRoSCoPy, PHEnoTyPInG,
CHEmoTyPInG, PRoCESS EnGInEERInG oF
AGRICUlTURAl PRoDUCTS
The specificity of the BIBS platform lies in the combined use of several
analytical techniques to characterize the fine structure, the organization,
the interactions and the localization of biopolymers at different scales,
from the nanometer up to the millimeter scale.
The questions addressed concern the relationship between structures
and resulting properties (nutritional, biological, technical) of the systems
formed by these biopolymers. The available equipment also enables to
evaluate the structural and composition variability of biopolymers in large
collections of samples.
Analyses can be performed on a variety of substrates and objects arising
from biological or structured, food and non-food systems resources, in
the fields of agronomy and marine research (and field of health for certain
techniques).
The BIBS platform is located on the InRA (French national institute for
agriculture research) Centre of nantes, and is part of the BIA research
unit (Biopolymers – Interactions – Assembly) and the CEPIA department
(Science and Process Engineering of Agricultural Products). It was granted
the IBiSA national label in 2010 and is part of the Biogenouest facility
network.
Techniques:
Address
INRA UNITÉ BIA
Plate-forme BIBS
Rue de la Géraudière - B.P. 71627
44316 nAnTES
FRAnCE
Contact detail
Hélène RoGnIAUX
Tel. +33 (0)2 40 67 50 34
helene.rogniaux@nantes.inra.fr
mass spectrometry
microscopies
nuclear magnetic Resonance
Phenotyping/Chemotyping
main applications on biopolymers (polysaccharides and proteins):
multi-scale observations (from molecular to µm level), localization
medium throughput profiling of proteins and polysaccharides
(proteomics of sequenced and non-sequenced organisms,
polysaccharidomics)
Fine structure elucidation
Surface states, local arrangement, mobility at the nanometric scale
Interactions, supramolecular assemblies
Hydration properties
monitoring of transformation (industrial processes, heating, cooling,
etc.)
mobility/diffusion of small molecules in situ
Screening of structural and compositional variability
ACCESS PolICy
The platform is available to scientists from academic laboratories or from
private companies, whose scopes of interest are in the field of biopolymers, their
structure and their organization.
Available service includes: analytical service, training of users, collaborative work
A request form is downloadable from the facility website
All analyses are charged
www.bibs.inra.fr
10
BIODIMAR®/UBO
location
BREST, FRAnCE
Key words
BIomolECUlES, EXTRACTIon, PURIFICATIon, SAmPlE PREPARATIon, AnAlySIS,
TITRATIon, BIoloGICAl SCREEnInG
Biodimar® has developed an expertise in the extraction, purification and
analysis of biomolecules:
Collection of samples or organisms and supply of biomass or extracts
Compound purification
Screening for biological activities
lyophilisation, grinding/shredding, extraction and concentration
Physical chemistry analyses
Antioxidant activity assays
Anti-aging activity assays
our client sectors include pharmaceuticals, cosmetics, blue (marinesourced) and red biotechnologies as well as agrifood.
The main technological offers of the platform are:
Sample on-field characterization, gathering and preparation
(fractionation and purification).
Freeze-drying and grinding large capacity.
Accelerated Solvent Extraction (ASE), from 40 to 200°C, all solvent
types (organic and aqueous).
Evaporation/concentration and samples conditioning (96 wellplates...).
Analytical development adapted to fractionation and purification of
marine natural products.
Solid Phase Extraction chromatography (10-50mg).
Flash chromatography with Uv detector (20mg-2g).
High Performance liquid Chromatography analytic and preparative with
DAD and ElSD detectors (10-100mg).
molecule identification, structural analysis and quantification (nmR,
mass spectrometry…).
Biochemical quantifications (sugars, phenolic compounds, protein…).
Screening and biological testing
Antioxidant capacity (oRAC, DPPH, FRAP…).
Enzyme inhibition activities (amylase, glucosidase, lipase, tyrosinase,
elastase…).
Tests can be developed upon request.
Address
UNIVERSITÉ DE BRETAGNE OCCIDENTALE
UFR Sciences Techniques - Batiment A
6 avenue de Gorgeu
29238 BREST
FRAnCE
ACCESS PolICy
The platform is located on the scientific campus UFR Sciences and Techniques of
University of Brittany (UBo), Brest, France.
Contact detail
Elise PETIT RoDAT
Tel. +33 (0)2 98 01 66 50
biodimar@univ-brest.fr
www.univ-brest.fr/BIoDImAR
11
BIOGENOUEST
GENOMICS
location
nAnTES, REnnES AnD RoSCoFF
FRAnCE
Key words:
DnA mICRoARRAyS, SEQUEnCInG, GEnoTyPInG, nEXT GEnERATIon SEQUEnCInG
(nGS), GEnETICS, FUnCTIonAl AnD InTEGRATIvE GEnomICS
Biogenouest Genomics provides equipment and technical support to
projects in genomics (sequencing, genotyping, transcriptomics) in the
fields of human health, marine biology, agriculture/food-processing, and
environment. The facility designs and develops coherent methods and
tools in functional and integrative genomics (dedicated, high-throughput
approaches).
Services include
Genomics : sequencing, gene copy number changes and/or genotyping)
Transcriptomics: mRnA expression profiling on microarrays,
microRnA/qPCR assays , RnA-Seq, meta RnA-seq
Amplicons mass-sequencing
Epigenetics: CpG Island microarrays, bisulfite pyrosequencing and
qPCR assays
Statistical and bioinformatic analyses of microarray data
The technologies currently available include:
Sequencing and genotyping using ABI capillary sequencers
nextGen sequencing on Roche/454 GS FlX, Illumina HiSeq, Illumina
miSeq
microarray analysis on Affymetrix GeneTitan mC, Illumina iScan and
Agilent scanner
Real-time PCR applications on Roche lighCycler and ABI7900 machines
Address
GENOMICS CORE FACILITY
CnRS UmR 6553 EcoBio - oSU de Rennes
263 Avenue du General leclerc
CS 74205
35042 REnnES Cedex - FRAnCE
GENOMIC PLATFORM OF NANTES
l’institut du thorax/Inserm UmR 1087
IRT-Un - 8, quai moncousu
BP70721
44007 nAnTES Cedex 1- FRAnCE
Contact detail
Philippe vAnDEnKooRnHUySE
Tel. +33 (0)2 23 23 50 07
Philippe.vandenkoornhuyse@univ-rennes1.fr
Richard REDon
Tel. +33 (0)2 28 08 01 41
Richard.Redon@univ-nantes.fr
www.biogenouest.org
12
THERASSAY
FUNCTIONAL EXPLORATION FOR SMALL
ANIMALS IN THE FIELD OF CARDIOVASCULAR, METABOLIC, RESPIRATORY, DIGESTIVE, MOTOR AND CANCER PATHOLOGIES
(BIOGENOUEST)
location
nAnTES, FRAnCE
Key words
FUnCTIonAl AnAlySIS, AnImAl moDElS,
GlP, ElECTRoPHySIoloGy CARDIovASCUlAR FUnCTIon, mETABolIC FUnCTIon, RESPIRAToRy FUnCTIon, DIGESTIvE FUnCTIon,
moToR FUnCTIon, CAnCER
DOMAINS OF EXPERTISE AND SERVICES OFFERED :
THERASSAy is a functional exploration facility aiming to supply biopharmaceutical companies and academic research groups with a large panel of
technological tools and scientific expertise to ensure a successful route
to new therapeutics. It is an open platform that offers a unique service,
ranging from the generation of animal models to highly specialized functional analyses, for complete cardiovascular, metabolic, respiratory, digestive
and motor functions exploration.
located in the nantes University Hospital, the facility is composed of
animal housing facilities, cell culture laboratories, molecular and cellular
biology laboratories, histopathology and microscopy laboratories and
areas dedicated to in vivo assays. Since June 2009, the THERASSAy
platform occupies a surface of 300 m² in the new research institute IRTUn (Institute of Therapeutic Research of University). It received the IBiSA
French national label and is a member of Biogenouest, the life science and
environment core facility network in Western France.
TECHNIQUES AND EXAMPLES OF APPLICATION :
The THERASSAy platform is organised around 7 scientific modules (metabolic, cardiac, vascular, pulmonary, motor, digestives functions evaluation
and cancerogenesis).
our services include the development of new animal models of human diseases by gene extinction/targeted silencing RnA technology or gene surexpression by DnA vectorization. All are associated and allow us to offer
a relatively complete phenotyping service. We can characterize diabetes,
dyslipidemia, hypertension, asthma, arrhythmia, myopathy…
The generation of somatic mutations in mouse coupled to appropriate
phenotyping platforms, represents a powerful tool to exploit the physiological and biochemical pathways of this given gene. In addition, the same
phenotyping platforms can be used to determine the efficacy of pharmacological or nutritional compounds.
ACCESS PolICy
Address
THERASSAY
IRT-Un
l’institut du thorax - UmR 1087
8 quai moncousu
BP 70721
44007 nAnTES Cedex 1
FRAnCE
Demands can be submitted by contacting directly the platform and are subject
to approval by the Platform Scientific Committee. The platform can accept to
perform projects as services or collaborations.
In addition, THERASSAy also offers access to equipment which includes technical
support and training by our engineers.
Contact detail
maud CHETIvEAUX
www.therassay.com
www.cardiex.univ-nantes.fr
maud.chetiveaux@univ-nantes.fr
13
CORSAIRE
(BIOGENOUEST)
location
BREST, nAnTES, REnnES, RoSCoFF,
FRAnCE
Key words
mETABolomICS, lIPIDomICS, nUTRACEUTICAlS, ACTIvE ComPoUnDS, PlAnT HEAlTH,
AGRo-FooD, HUmAn AnD AnImAl HEAlTH
CoRSAIRE is a metabolomics platform of Biogenouest, the life science and
environment core facility network in Western France. The platform activities, which aim at analyzing metabolic profiles, rely on nuclear magnetic
resonance (nmR) and various associated techniques of chromatography
and mass spectrometry (mS).
The platform is located in 4 different cities (nantes, Rennes, Brest and Roscoff) and 9
sites and is supported by Higher Education and Research centres such as Agrocampus
ouest, IRSTEA, CnRS, InRA, InSERm, onIRIS, University of Brest, University of nantes and
University of Rennes 1.
Each of those sites masters a specificity resulting from instrumentation, techniques, know
how or scientific domains:
metabolomics applied to agronomy, environmental sciences, marine sciences,
and food sciences
metabolomics, lipidomics and structural analyses in the field of Health
Aliments security
Plants and product quality
Environment, etc.
Analytical competences developed in each site of CoRSAIRE allow the conduction of qualitative and quantitative analyses on a broad range of metabolites families extracted from
numerous sorts of biological matrixes.
Besides, the platform can answer both to targeted analyses of biological molecules and to
broad analyses (i.e. metabolism profiles with statistical analyses) as well as to integrated
metabolomics studies.
The CoRSAIRE platform, thanks to the complementarity of its sites, prometabolomics approach
poses the following services:
Structural characterization of metaboTargeted analysis of metabolites
metabolite profile
metabolite footprints
lites, etc.
The main analyzed metabolites families that can be extracted from various
biological matrixes are:
Address
CORSAIRE – BIOGENOUEST
Centre InRA
Domaine de la motte
BP 35327
35653 lE RHEU Cedex
FRAnCE
Contact detail
laurent RIvET
Tel. +33 (0)2 23 48 52 15
laurent.rivet@rennes.inra.fr
volatile organic compounds (voCs)
Halogenated voCs
Fatty acids
Aldehydes
Amines and Polyamines
Alkaloids
organic acids
Terpenes
Endocrine disruptors
Primary metabolites
Sugars
Alcohols and polyalcohols
Phenols and polyphenols
Amino acids
Dioxins
Polycyclic aromatic hydrocarbons (PAHs)
Polychlorinated biphenyl (PCBs)
lipids
Secondary metabolites, etc.
Importantly, CoRSAIRE proposes a biostatistics analysis of results, which
is necessary to highlight discrete perturbations of metabolic pathways.
Equipment of the platform encompasses:
HPlC , lC-mS (maldi, ESI, orbitrap, Q-Tof), lC-mS/mS, lC-mSn-HRmS, GC-mS, GC-mS/mS,
GC/mS isotopic,- GC-FID, GC-IRmS, GC-HRmS, GC-C-IRmS, nmR 300 mHz, 400 mHz and
500 mHz with cryoprobe, HRmAS, 1H1, 13C, 31P, …etc.
ACCESS PolICy
Each project has to be presented to the manager of the platform. Then, the
project is submitted to a committee of users for acceptance. Both academics and
companies projects can be performed.
www.biogenouest.org
14
H2P2
HISPATOLOGY
HIGH-PRECISION CORE FACILITY
(BIOGENOUEST)
location
REnnES, FRAnCE
Key words
lASER CAPTURE mICRoDISSECTIon, TISSUE
mICRo ARRAyS, vIRTUAl SlIDES, BIomARKER, PHARmACoToXIColoGy, ImmUnoHISToCHEmISTRy, nUClEIC ACID EXTRACTIon
AnD AmPlIFICATIon
The facility offers standard histology lab services plus custom laser capture microdissection. The facility is ISo 9001 certified.
The main applications are:
Diagnostics/screening (toxicity, mode of action) at the tissue level
Understanding of physiological and physiopathological mechanisms
Drug target discovery
Analysis of bioactive molecules
Pharmacology, toxicology, pathology
Tissue genomics
Following equipment and/or techniques are available:
A microtome to realize thin tissue sections of paraffin embedded tissue
A cryostat for thin sections of frozen tissue
Specific staining techniques (emphasis in fibrosis, steatosis, glycogen
content ...)
Image analysis (nuclear staining count, fibrosis quantification, steatosis
quantification, emphysema,…)
In situ hybridization and immunohistochemistry revealed by enzyme or
fluorochrome.
A laser Capture microdissector (veritas ARCTURUS), that enables to
specifically and accurately isolate defined cells within a complex tissue.
Protocols have been developed to capture specific cells present in different tissues: human, animals (mouse, zebrafish) or plants (rapeseed,
brown algae) and in culture cells.
Following cell capture, nucleic acids are recovered using micromethod.
Address
UNIVERSITÉ DE RENNES 1
2 avenue du Pr léon Bernard
CS 34317
35043 REnnES Cedex
FRAnCE
Contact detail
Alain FAUTREl
Tel. +33 (0)2 23 23 47 95
Fax: +33 (0)2 23 23 49 29
alain.fautrel@univ-rennes1.fr
http://histopathologie.univ-rennes1.fr
15
IMPACCELL
HIGH CONTENT SCREENING CORE
FACILITY (BIOGENOUEST)
location
REnnES, FRAnCE
Key words
ToXIColoGy, PHARmAColoGy, HEAlTHCARE, CAnCER, nUTRITIon, EnvIRonmEnT
ImPACcell offers its skills, expertise and analytical resources in large-scale
biological screening assays based on automatized high content image
analysis:
Toxicity and activity assays for drugs, chemicals, environmental pollutants and toxins, etc.
Specific liver toxicity assays
Gene expression analysis by multiparametric fluorescent tests
Pre-clinical validation of bioactive molecules: screening and search for
mechanistic targets
Advice on cell culture and models
ImPACcell core facility has particular expertise in the following areas:
IC50 determination of compounds on different cancer cells
Qualitative and quantitative tests related to cell growth, ageing, death
and motility…
Qualitative and quantitative analyze of Cell signaling pathway activation
Cell culture in microsystems supporting imaging and high-content
screening
ACCESS PolICy
Contact the core facility director who will help you to define the experimental process. The core facility staff operates the cell culture, treatment with the molecules
and the biological tests. The image capture and analysis are carried out by the
engineers, as well as data mining. Training will be provided upon request.
Address
IMPACCELL CORE FACILITY
SFR BIoSIT, Bât. 8
Université de Rennes 1
35043 REnnES Cedex
FRAnCE
Contact detail
Anne CoRlU/Rémy lE GUévEl
Tel. +33 (0)2 23 23 48 10
Fax: +33 (0)2 23 23 45 62
anne.corlu@inserm.fr
remy.leguevel@univ-rennes1.fr
http://imagerie-puces-a-cellules.univ-rennes1.fr
16
IMPACT
MOLECULAR INTERACTIONS
PROTEINS MICROARRAYS ACTIVITIES
(BIOGENOUEST)
location
nAnTES, FRAnCE
Key words
molECUlAR InTERACTIonS DETERmInATIon, CHARACTERISATIon AnD
moDUlATIon oF PRoTEIn InTERACTIon
– PRoTEIn PRoFIlInG AnD InTERACTAnT
SCREEnInG
In proteomics, analysis of biomolecular interactions is of great interest to understand protein interaction networks (proteins-proteins, proteins-DnA, etc.).
The ImPACT core facility offers a set of cutting-edge technologies to study
molecular interactions, from high throughput screening to structural and functional characterization of interactions using biophysical tools. The privileged
field of expertise of the platform is the characterization of protein interactions
with biopolymers (polysaccharides, proteins, fatty acid, nucleic acids) or small
ligands as well as their identifications and their modulations.
Impact provides access to four sets of analytical techniques: protein arrays,
Surface Plasmon resonance, calorimetry and spectroscopy. By grouping
together all these technologies, the ImPACT platform offers a wide range of
investigation, from the biomolecular partners level up to the high-throughput
scale (multi target or multi prays range) in an integrative approach to reach
protein networks.
This core facility, set up in February 2009, collaborates with other core facilities of Biogenouest, the life science and environment core facility network in
Western France.
TECHNIQUES AND EXAMPLES APPLICATION
The platform is located on the scientific campus (FRE-CnRS n°3478 Fonctionnalité et Ingénierie des Protéines-UFIP) and in the Institute of therapeutic research (UmR InSERm 892) of nantes.
The main technological offers of the platform are:
Discover a new set of protein interactions from cellular, tissular extracts …. to
analyse differential proteins expression, post-translational modifications …..
Highthroughput screening: protein arrays, small molecule arrays, SPR ImAGInG and HTRF-BRET
validate interactions at the structural and functional level.
Biophysical approaches: SPR, microcalorimetry, circular dichroism, fluorescence
modulate interactions involved in signalling pathways, functionality in different
cellular types or tissues using new screening procedures.
Address
IMPACT
FRE-CnRS n°3478
Fonctionnalité et Ingénierie des Protéines
(UFIP)
Faculté des sciences et techniques
2 rue de la Houssinière
44322 nAnTES Cedex 3 - FRAnCE
Contact detail
Cathy CHARlIER
Tel. +33 (0)2 51 12 56 21
Fax: +33 (0)2 51 12 56 37
cathy.charlier@univ-nantes.fr
mike mAIllASSon
Tel. +33 (0)2 40 08 47 44
mike.maillasson@univ-nantes.fr
Equipment:
For proteins microarrays design and screening: Affymetrix Spotter, PerkinElmer
and li-Cor Scanners, PerkinElmer protein array workstation, Agilent Bioanalyzer, Qiagen Biorobot, Berthold mithras.
For biophysical analyses: GE Healthcare BIAcore and SPRi, Qiagen Tissuelyser,
Jasco Spectropolarimeter, Jasco Spectrofluorimeters, Jasco Spectrophotometer, Jasco Fluorescence polarization Photometer and microCal microcalorimeter.
For data analysis: Genepix pro v4, vigentech microvigen, PerkinElmer ScanArray microarray Analysis system, StatEl, GE Healthcare BIAeval 4.1
ACCESS PolICy
To access ImPACT services, please contact the platform staff in order to specify
the experimental strategy and to book equipment. For this purpose, a project form
is downloadable on the ImPACT website.
once the project is approved, experimental specifications are established.
www.impact-plateforme.com
17
MICROPICELL
CELLULAR AND TISSULAR IMAGING
CORE FACILITY OF NANTES
UNIVERSITY
(BIOGENOUEST)
location
nAnTES, FRAnCE
Key words
CEll AnD TISSUE ImAGInG, CEllUlAR
moRPHoloGy, ImmUnoCyToCHEmISTRy,
HISToloGy, mICRoDISSECTIon, ConFoCAl
AnD FlUoRESCEnCE mICRoSCoPy
The Cellular and tissular imaging core facility of nantes University (microPICell) encompasses two technical departments:
PICell (for cell imaging)
micromorph (for cellular morphology)
The microPICell platform proposes a regulated access to imaging systems
and services in histology.
The expertise of the platform allow technical and scientific assistance for
the development, the realisation and the analysis of research projects and
specific experiments. moreover, microPICell organizes various training
sessions to microscopy techniques through the InSERm (French national
institute of health and medical research) training program.
The techniques mastered by microPICell include:
Epifluorescence
microinjection
videomicroscopy
Confocal microscopy
FlIm (Fluorescence lifetime Imaging microscopy)
Confocal spectral separation
High throughput confocal acquisition
Intracellular ionic measurement
Histology techniques
Tissue micro-Array (TmA)
laser microdissection, etc.
The main equipment of microPICell is:
PICell: confocal leica (SP1), confocal nikon (A1-R-S), Zeiss time-lapse
equipment with apotome (Axiovert200), leica time-lapse system
(DmI6000B) with metamorph and metafluor, leica microinjection
system, 3 routine fluorescence microscopes, Image analysis platform
(metamorph, Huygens deconvolution, Amira 3D), Co2 incubators
micromorph: 2 cryostats (leica), 1 Bond- max menarini robot, 2 microtomes, TmA (tissue microarrayer, Imstar), laser microdissection (Arcturus Pixcell II)
Address
MICROPICELL
IRT-Un
8, quai moncousu
BP 70721
44007 nAnTES Cedex
Contact detail
myriam RoBARD
ACCESS PolICy
The microPICell platform is open to both academic and private sectors.
Access is strictly regulated:
1. Contact with the platform manager (evaluation of user needs, information
about costs and equipment reservation)
2. Writing of specifications
3. The password allowing online reservation of equipment is granted after a user
training
Tel. 06 75 61 81 71
myriam.robard@univ-nantes.fr
www.micropicell.univ-nantes.fr
18
MOLECULAR
CYTOGENETICS
PCMV
(BIOGENOUEST)
location
lE RHEU, FRAnCE
Key words
CHRomoSomES, STRUCTURE, mIToSIS,
mEIoSIS, GISH, BAC-FISH
The aim of the molecular Cytogenetics Platform is to pool technical
resources, investment and skills. This platform located at the InRA (the
French national Institute for Agricultural Research)-UmR1349 of Rennes
must answer to the local teams but also to all teams belonging to different
other InRA laboratories. The molecular Cytogenetics Platform provides an
infrastructure to support research projects that develop molecular cytogenetic technologies on different plants species (Brassica, Wheat, Tomato,
Cotton, Grapevine, lolium, lupinus…) for:
Cytogenetic characterization of interspecific hybrids or polyploids
species,
Understanding the genomes structure in polyploids species,
Fine physical maps around locus of interest
Techniques developed:
localisation of repeated sequences on chromosomes by Fluorescent In
Situ Hybridization (FISH),
Genomic In Situ Hybridization (GISH) to characterize the parental genome in the interspecific hybrids or polyploids species,
Physical mapping of BAC clones on mitotic or meiotic chromosomes,
BAC-FISH on nuclear fiber to identify sequence rearrangements or gaps
in sequencing projects (BAC Fiber-FISH)
ACCESS PolICy
Acceptance and feasibility of projects are evaluated by the core facility managers
in accordance with the scientific committee.
Address
INSTITUT DE GÉNÉTIQUE
ENVIRONNEMENT ET PROTECTION DES
PLANTES (IGEPP)
UmR1349
Bât. 301
InRA Centre de Rennes
BP 35327
35653 lE RHEU Cedex
FRAnCE
Contact detail
olivier CoRITon
Tel. +33 (0)2 23 48 51 49
olivier.coriton@rennes.inra.fr
www.rennes.inra.fr
19
MRIC
MICROSCOPY RENNES IMAGING
CENTER (BIOGENOUEST)
location
REnnES, FRAnCE
Key words
ConFoCAl, mUlTIPHoTon mICRoSCoPy,
ElECTRon mICRoSCoPy, CRyomICRoSCoPy, TomoGRAPHy, nAnoSImS, vIDEomICRoSCoPy
The microscopy Rennes imaging center (mRic) offers access to imaging
systems, scientific and technical support in experimental and project design and training in microscopy techniques.
The core facility has special expertise in:
Rapid, real-time in vitro cell imaging
Structural analysis
molecular and atomic imaging
Protein-protein interactions (FRET and FlIm)
In vitro enzyme assays
Correlation fluo-TEm and Fluo-nanoSImS
The microscopy Rennes imaging center has received a national label in
2009.
The microscopy Rennes imaging center (mRic) comprises:
mRic-FlUo: fluorescence microscopy
mRic-TEm: transmission electron microscopy
mRic-nAno: nanoSImS (high-resolution secondary ion mass spectrometry)
ACCESS PolICy
Anybody who wants to use the core facility must first contact the technical staff,
register as a user and accept the rule of the platform. In any case users must be
trained to use the machines.
Some complex machines are not in free access such nanoSImS and TEm, the use
of these machines is conditioned by the presence of the technical staff.
Address
MICROSCOPY RENNES
IMAGING CENTER (MRIC)
Faculté de médecine
35043 REnnES
FRAnCE
Contact detail
Claude PRIGEnT
Tel. +33 (0)2 23 23 47 31
Fax: +33 (0)2 23 23 44 78
claude.prigent@univ-rennes1.fr
http://microscopie.univ-rennes1.fr
20
NEURINFO
IMAGING AND NEUROINFORMATICS
CORE FACILITY
(BIOGENOUEST)
location
REnnES, FRAnCE
Key words
mEDICAl ImAGInG, BRAIn ImAGInG,
RADIoloGy, nEURoSCIEnCES,
nEURoInFoRmATICS, mRI, ImAGE
PRoCESSInG, DATA mAnAGEmEnT,
SoFTWARE DEvEloPmEnT, ClInICAl
RESEARCH
neurinfo offers resources for image acquisition, handling and processing
in clinical, methodological and technological R&D.
This facility covers in vivo human imaging and neuroinformatics, notably in
the setting of nervous system disease. neurinfo’s goal is to contribute to a
better understanding of the healthy and diseased human brain.
neurinfo strives to integrate clinical research projects from the image to
the patient and perform technology transfer of image processing methods
to the clinic.
neurinfo is currently equipped with a 3T mRI system located at Rennes
University Hospital. It is operated by dedicated technical staff with expertise in the field of mRI physics and image processing, in collaboration with
staff from the University Hospital’s Radiology Service.
ACCESS PolICy
The neurinfo core facility promotes networking between the various stakeholders
in medical imaging. It is open to a broad community of medical and scientific users
on the regional, national and international levels.
Address
NEURINFO
SERVICE DE RADIOLOGIE, IRM RDC
Hôpital Pontchaillou
2 rue Henri le Guilloux
35033 REnnES Cedex 9
FRAnCE
Contact detail
Christian BARIlloT
Tel.+33 (0)2 99 28 99 07
contact@neurinfo.org
www.neurinfo.org
21
ONIS
ONIS
NATIONAL OBSERVATORY FOR
SCIENTIFIC IMAGING
location
REnnES, FRAnCE
Key words
AnAlyTICAl ImAGInG, SPECTRoSCoPy,
SPECTRomETRy, nAnoSImS AnD RAmAn,
FlUoRESCEnCE ImAGInG, 2D/3D ImAGInG,
TEm, mICRomETER AnD nAnomETER
TECHnIQUES
onIS («observatoire national d’imagerie scientifique») is a high-performance, multi-scale analytical imaging core facility.
Its equipment can visualise the chemical composition point by point in a
tissue, a polymer, a soil sample, an insect, a plant or a lichen, etc., from the
millimeter scale down to the nanometer scale.
The facility offers imaging and elemental analysis services, personalized
customer support services and protocol design, testing and image analysis and processing.
onIS also offers face-to-face training or e-training. It is a member of the
Europia network.
Raman imaging system: confocal and fiber for long distance analysis.
nanoSims: imaging at 50 nanometers spatial resolution of any element
or isotope of the periodic table
2D imaging of complex samples: detection of spots after separation
using Uv, Fluorescence, mass,…
Address
ONIS
Campus de Beaulieu
263 avenue du Général leclerc
CS 74205
35042 REnnES Cedex
FRAnCE
Contact detail
olivier lAvASTRE
Tel. +33 (0)2 23 23 56 30
olivier.lavastre@univ-rennes1.fr
22
PRISM
FUNCTIONAL IMAGING CORE FACILITY
(BIOGENOUEST)
location
REnnES, FRAnCE
Key words
ImAGInG, SPECTRoSCoPy, mRI, nmR,
TomoGRAPHy, SCAnnER
PRISm is a research platform located in Rennes under the responsibility
of the University of Rennes 1, InRA and IRSTEA. PRISm has the national
label IBiSA “national network of Infrastructures in Biology, Health and
Agronomy“
The activities covered by the core facility include:
multimodality imaging of pig
mRI and SRm of small animals and clinical application
mRI and nmR for agronomy and food chain (this component is ISo
9001 certified)
nmR spectroscopy of biological materials
PRISm is supported by four research teams. They provide tools compatible with their own scientific expertises. Each of them contributes to the
leading position of PRISm in France.
Indeed, the multidisciplinary expertise of the staff (14 scientists and 17
engineers and technicians) allows demands coming from scientists from
the biomedical, biology, food science and food engineering sectors to be
answered, which is unique in France and in Europe.
The functional imaging core facility PRISm offers a range of outstanding,
well-matched methodological skills (imaging, spectroscopy, mRI, nmR
and CT) for the investigation of experimental models on the molecular
scale (proteins, lipids, etc.), the cell level (bacteria, membranes, etc.), the
tissue level (muscle, tumours, etc.), in the small animal (mice, rats, fishes
and rabbits) and in larger animals (chickens, sheep and pigs).
Address
PRISM
IRSTEA
17 avenue de Cucillé
CS 64427
35044 REnnES Cedex
FRAnCE
Contact detail
François mARIETTE
PRISm has specific expertise in the following areas:
The biomedical sector: morphological and functional typing of transgenic animals, dynamic studies of drug activity, digestive impact of food
product formulations and neurofunctional satiety studies
Biology and agronomy: quantification of tissue distribution in animal and
plant systems, membrane system studies, etc.
Food science: ingredient and food product processability, water retention properties and storage stability testing
Process engineering: mass and heat transfer analysis for bioproducts.
ACCESS PolICy
Acceptance and feasibility of projects proposed by the user teams are evaluated
by the core facility managers in accordance with the scientific committee. PRISm
offers scientific collaborations and service for fee to private and public organizations.
Tel. +33 (0)2 23 48 21 78
Fax: +33 (0)2 23 48 21 15
françois.mariette@irstea.fr
http://prism.univ-rennes1.fr
23
PRODIABIO
location
PonTIvy, FRAnCE
Key words
BIoPRoCESS, EnvIRonmEnTAl DIAGnoSIS,
BIoRESoURCES
The ProDiaBio facility (for PRocess, DIAgnostics, BIoresources; accredited
by AFnoR since 2005) is located at the center of the Breton food-feed
production area. It aims at helping small to medium-size companies
enhancing their competitiveness by supplying comprehensive transfer
protocols and advice.
It has significant skills in waste and effluent treatment and valorization of
industrial co-products (methanization, biodigestion, a.s.o.). Cooking trials
and food product formulation can be performed in the agrifood process
hall and its associated sensorial analysis unit. ProDiaBio’s expertise in
liquid and solid biofuels (boilers, stoves, a.s.o.), mechanical engineering,
automation and maintenance enables it to meet the needs of industrial
business, territorial authorities and farm managers. The facility may host
customer’s preindustrial pilots. Confidentiality is the rule for all attendants.
The core facility offers, as delivery or hosting, various services to
companies to help them in shortening development times.
The use of comprehensive bioprocessing equipments supports the quick
establishment of valid bioprocesses, and facilitates easy and reliable scaleup from lab to production plant. Diagnostics, prototyping, setup or process
optimization, physicochemical and microbiological analyses are some of
the services that the platform may be yours due to the skill of its scientific
and technical team that make the facility both appropriate and reactive.
Some projects achieved:
Development of a concentrating and drying process for a waste
treatment company,
Screening of innovative entrants as fuel for farm methanization units,
optimization and validation of a green Cleaning In Place process with
high levels of cleaning solutions recycling for dairies,
Forensics to investigate co-products innovative valorization pathways,
valorization of fat effluents of a sausage factory which allows energy
autonomy and environmental impact reduction,
monitoring and mastering positive biofilms for a pig liquid feed
fermentation process to fulfill European guidelines.
Address
PRODIABIO
Centre Universitaire
de Pontivy
Allée des Pommiers
56300 PonTIvy
FRAnCE
ACCESS PolICy
Servane RoZE
PRoDIABIo is designed to be reactive towards small or medium size companies
which cannot develop R&D on their own, towards project managers who plan
process innovation or optimization in, or out, an entrepreneurship context
for bioprocesses related to agro food-feed industries, chemistry, bio-industry,
pharmaceutical, cosmetology and environment fields. Confidential and targeted
dating along with rapid quotation are keys that confer us the reactivity that fits our
customers demand.
Tel. +33(0) 297 279 768
servane.roze@univ-ubs.fr
www.pft-prodiabio.com
Contact detail
24
BIOGENOUEST
PROTEOMICS
CORE FACILITY
location
REnnES, FRAnCE
Key words
PRoTEomICS, mASS SPECTRomETRy,
PEPTIDES, PRoTEInS, BIomARKERS,
IDEnTIFICATIon
The Biogenouest Proteomics Core Facility offers timely and affordable
tools, from basic protein identification to large-scale proteomics programs
using state-of-the-art technologies.
The core facility is staffed with highly specialized engineers, involved in
optimization and validation of cutting-edge technologies in two fields of
proteomics: extensive proteome characterization of complex samples and
imaging mass spectrometry for toxicology and clinics. It is also developing
integrative genomics approaches for extraction of biological information
from large-scale proteomics datasets.
The Proteomics core facility was granted the IBiSA national label in 2008
and is ISo 9001 certified.
To help you achieve your research projects and advise you as best as
possible in your proteomics approach, we propose to answer biological
questions through a wide range of complementary technologies specific to
proteomics.
main techniques:
Biochemistry: protein fractionation, proteins separation and purification,
enzymatic digestion
Systematic functional proteomics: 2D electrophoresis and protein
identification by mass spectrometry mAlDI-ToF/ToF (mS and mS / mS
fully automated), 1D electrophoresis and protein identification by mass
spectrometry lC-mS/mS type (also used for the detection and identification of protein partners)
Differential proteomics: (1) relative quantification using 2D-DIGE technology, or protein chips (ProteinChip ® technology), or mass spectrometry
(ICPl technology), and (2) absolute quantification of biomarkers using
the AQUA peptidesTm technology
In situ proteomics: imaging mAlDI on cryo-tissue sections.
ACCESS PolICy
Address
PLATE-FORME PROTÉOMIQUE
BIOGENOUEST
Campus de Beaulieu - Bât. 24
Avenue du Général leclerc
35042 REnnES Cedex
FRAnCE
Contact detail
Charles PInEAU
Access to the Biogenouest proteomics core facility is by two ways:
- Scientific collaboration for projects using advanced technology requiring platform team investment
- Self-service, following training, for protein identification into gel pieces or data
analysis (imaging, spectrum…).
The core facility doesn’t work on a fee-for-service basis.
The first step is to fill in an account application on the facility website, then to
download the project document to complete and send to
proteome@univ-rennes1.fr. Finally, a meeting with the platform staff is planned to
expose us your problematic and the biological asking questions.
Tel. +33 (2) 23 23 52 83
Fax: +33 (2) 23 23 52 82
proteome@univ-rennes1.fr
www.proteome.univ-rennes1.fr
25
RAT TRANSGENESIS
FACILITY
(BIOGENOUEST)
location
nAnTES, FRAnCE
Key words
RAT TRAnSGEnESIS, KnoCK-oUT RATS,ZInCFInGER nUClEASES, TAlE nUClEASES,
ImmUnoPHEnoTyPInG
The rat transgenesis facility is a functional exploration facility for the in vivo
functional studies of novel genes.
The main activities are:
generation of transgenic rats by microinjection of DnA or lentiviral
vectors, generation of targeted Knock-out (Ko) rats using Zinc-finger or
TAlE nucleases, genotyping of genetically modified rats, identification of
transgene insertion loci in the genome, immunophenotyping & analysis
of immune response of genetically modified rats, freezing of transgenic
embryos, technical support, training, technology transfer to industry.
The Biogenouest rat transgenesis core facility is the only academic
structure that produces genetically modified rats in France, and the only
academic facility in Europe to provide external users with transgenic and
Ko rats.
The Rat transgenesis core facility is located in the InSERm (French
national institute of health and medical research) unit 1064, which is
situated in the nantes University Hospital.
The work of the rat transgenesis facility is performed in the InSERm Unit
animal facility which includes an isolated microinjection room, laboratory
space and breeding rooms exclusively for the transgenic/Ko rats. The
molecular biology, cell culture and protein biochemistry work is done in the
laboratories of the InSERm Unit 1064.
main techniques:
microinjection using small or large fragments of DnA
microinjection using lentiviral vectors
microinjection using zinc-finger or TAlE nucleases
Genotyping is performed by classical PCR, Southern-blot, Taq-man
(determination of homozygous status), genome walking (determination
of the insertion site of the transgene within the genome)
Cryopreservation: preservation of lines by freezing of embryos.
Availability of transgenic rats that have already been generated (on-line
list)
Address
INSERM UMR 1064
30, boulevard Jean monnet
44093 nAnTES
FRAnCE
Contact detail
Ignacio AnEGon
Ignacio.Anegon@univ-nantes.fr
Séverine Rémy
Severine.Remy@univ-nantes.fr
www.tgr.nantes.inserm.fr
26
RENABI-GO
BIOINFORMATICS FACILITY
(BIOGENOUEST)
location
nAnTES, REnnES, RoSCoFF,
FRAnCE
Key words
BIo-InFoRmATICS, GEnomICS,
TRAnSCRIPTomICS, DATA AnAlySIS,HIGH
PERFoRmAnCE ComPUTInG, nEXTGEnERATIon SEQUEnCInG, SoFTWARE
DEvEloPmEnT, DATABASES
RenaBi-Go provides a complete infrastructure dedicated to scientific
computing (clusters, storage facilities, data and tools), bio-analysis services
and a strong expertise in information systems development (databases,
interoperability, etc.).
RenaBi-Go provides consultancy and support in bioinformatics. A
complete cursus of bioinformatics training is offered: tools, methodologies,
programming languages. Custom developments can be carried out.
RenaBi-Go has received the IBiSA national label and two of its members
are ISo 9001 certified. It is a member of Biogenouest, the life science
and environment core facility network of Western France. It is part of
the national network RenaBi (Réseau national des plates-formes BioInformatiques).
RenaBi-Go offers a complete set of services in bioinformatics, public
databanks (updated with our BiomAJ tool) to support research and data
analysis.
more precisely, services provided are:
Bioinformatics infrastructure: this includes computing power (approx. 900
cores available as traditional cluster or cloud), storage (350 Tb) but also a
comprehensive list of software and databanks dedicated to biological data
analysis.
Advice and support in data analysis (genomics, transcriptomics,
metagenomics, annotation, etc.)
Software development. RenaBi-Go engineers conduct many developments
in different fields: interface development for new tools, databases, design
and development of information systems for processing and analysing data,
etc. They participate in different national or international software projects
(Debian-med, opal Toolkit, BiomAJ, etc.) .
Hosting. Through a partnership with different teams (national Research
Centres such as CnRS, InRA, InSERm, and University), RenaBi-Go
manages and hosts databases and web sites of interest for the scientific
community.
Technological transfer. RenaBi-Go transfers many research prototypes to
the community (for example: Protomata, logol, etc.)
Training activities (e.g. sequence analysis, pattern discovery, phylogenetics,
programming).
Address
Several locations among which
IRISA-INRIA
Campus de Beaulieu
35042 REnnES Cedex
FRAnCE
Contact detail
olivier CollIn
ACCESS PolICy
The platform is a public/educational facility providing services to the
bioinformatics community towards research progress. These resources are
accessible through web applications, web services and authenticated connexion to
a cluster for computationally intensive treatments.
As a ISo 9001entity, a strong emphasis is placed on the traceability of the
projects and on the relationship with customers and end-users.
For non-academic clients, the use of the facility resources or services is under
contract.
www.biogenouest.org
olivier.Collin@irisa.fr
27
SYNNANOVECT
location
BREST AnD REnnES, FRAnCE
The core facility offers several products and services:
DEVELOPMENT AND PRODUCTION
OF DRUG AND GENE SYNTHETIC
NANOVECTORS (BIOGENOUEST)
The Synnanovect core facility develops, optimizes and tests synthetic
nanocarriers for the delivery of nucleic acids (DnA and siRnA) and
biomolecules of interest.
Design and development of synthetic nanocarriers
Key words
BIoTHERAPy, GEnE AnD DRUG DElIvERy,
SynTHETIC vECToRS, In vIvo ImAGInG
ASSAyS, FoRmUlATIon, PHySICoCHEmICAl
CHARACTERIZATIon
nanocarrier formulation
Physical-chemical characterization
Delivery efficiency measurements
Pre-clinical safety testing
Electroporation
The Synnanovect Core Facility was granted the IBiSA national label in
2008 and it was renewed in 2011. ISo 9001 certification is in progress.
The core facility offers several products and services. The facility’s
chemistry lab specializes in vector synthesis and characterization.
The biology lab offers a wide range of in vitro and in vivo models and
various items of equipment for the in vivo assessment of nanocarrier
efficacy as well as their behavior, toxicity and inflammation parameters.
Electroporation facilities are also available in Rennes.
ACCESS PolICy
The applications and projects are to be sent to the core facility and are then
evaluated by the scientific coordination committee.
Address
SYNNANOVECT
Unité Inserm 1078 - Bât. 2bis
Hôpital morvan - CHU de Brest
5 avenue du maréchal Foch
29200 BREST
FRAnCE
Contact detail
Tristan monTIER
Tel. +33 (0)2 98 01 80 80
Fax: +33 (0)2 98 46 79 10
tristan.montier@univ-brest.fr
www.synnanovect.ueb.eu
28
VIRAL VECTORS AND
GENE TRANSFER
FACILITY
(BIOGENOUEST)
location
nAnTES, FRAnCE
Key words
vIRAl vECToRS, ADEno-ASSoCIATED
vIRUSES, GmP, PREClInICAl AnD ClInICAl
STUDIES
The viral vectors and gene transfer facility is a functional exploration
facility for the production of recombinant viral vectors at preclinical stages
for both the public and the private scientific communities. The main
activities are: i) development of new processes for the production and
characterization of viral vectors in accordance with good manufacturing
processes (GmP), ii) proof of concept, iii) production of recombinant
adenoviruses, adeno-associated viruses and lentiviruses, iv) construction
of plasmids (from above mentioned viruses) and v) the immortalization of
primary cells.
The viral vectors and gene transfer core facility particularly focuses its
R&D activities on adeno-associated viruses (AAv). Indeed, they have an
important therapeutic potential and they are more and more studied in
clinical trials.
In 2010, the development of quality insurance protocols by the
technological core facility in order to characterize viral vectors at
preclinical and clinical stages led to new collaborations with the Genosafe,
Afssaps and Généthon laboratories. moreover, the facility participated in
the ClInIGEn European excellence network.
This allowed the characterization of the AAv2RSS standard, and
currently to the characterization of AAv8RSS standard produced both at
Universitat Autonoma de Barcelona and our facility.
The viral vectors and gene transfer core facility is located in the InSERm
unit 1089, which is situated in the nantes University Therapeutic
Research Institute (IRT-Un).
The facility equipment encompasses:
Containment laboratories (l3 and l2)
Cell culture equipments
Ultracentrifuges (x4)
Digital refractometers (x2)
A fluorescence microscope
Chromatography lines (x4)
High-pressure homogenizer
Address
INSERM UMR1089 IRT 1
Université de nantes
8 quai moncousu BP 70721
44007 nAnTES Cedex 1 - FRAnCE
Contact detail
ACCESS PolICy
Services are accessible for any academic and private projects (estimate on
demand)
Services are realized according to validated client specifications
Real-time follow-up
Sample delivery by accredited transporter (paid by the client)
véronique BloUIn
Tel. +33 (0)2 28 08 04 33
ltg.production@univ-nantes.fr
www.vectors.nantes.inserm.fr
29
XENOPUS
TRANSGENESIS
FACILITY
(BIOGENOUEST)
location
REnnES, FRAnCE
The Xenopus biological resource center offers access to its expertise in
Xenopus breeding, production and transgenesis:
Sale and supply of Xenopus frogs and Xenopus oocytes expressing proteins of interest
Use of the Xenopus model in research
Creation of transgenic Xenopus carrying a promoter linked to a fluores-
Key words
EmBRyoloGy, DEvEloPmEnTAl BIoloGy,
CEll BIoloGy, PHARmAColoGy, ECoToXIColoGy, TRAnSGEnESIS, XEnoPUS
cent protein or another protein of interest
Testing of homologous or heterologous promoters
Gene-trap mutagenesis and the supply of mutants of interest
Training in Xenopus breeding and in vitro fertilization techniques
The Xenopus transgenesis core facility received the IBiSA national label in
2008 and is ISo 9001 certified.
The core facility is also a part of the national network CEPHElDIA (Création, Elevage, Phénotypage, Distribution et Archivage de modèles animaux
vertébrés) who wishes to federate animal models in basic and preclinical
research including: xenopus, fishes, rodents and primates.
The Xenopus Biological Resource Centre has two main objectives:
1) Provide animals, embryos and derivatives (oocytes, spawn, DnA etc.)
from two species of interest (Xenopus laevis and Xenopus tropicalis)
for the entire scientific community, both from the public and the private
sectors.It covers both wild animals and transgenic lines produced and
characterized in Rennes.
2) Allow teams willing to use the Xenopus model to meet their research
question without having to develop the infrastructure necessary for the
maintenance and use of animals.
It also provides training for animal keepers and for anyone interested in
using this model.
ACCESS PolICy
The demands are submitted to the contact persons by e-mail or via the website.
Then the strategy is defined and the experiments are conducted according to the
required specifications. The fee depends on the services provided.
Contact detail
Christophe HElIGon
Tel. +33(0)2 23 23 50 30
Fax: +33(0)2 23 23 67 82
christophe.heligon@univ-rennes1.fr
http://xenopus.univ-rennes1.fr
30
AGRIVAL
location
PloUénAn, FRAnCE
Key words
nUTRACEUTICAlS, DIETETICS, CoSmETICS,
AQUEoUS AnD SolvEnT-FREE EXTRACTIon,
nATURAl, oRGAnIC
Agrival is a specialist in the exploitation of plant-derived co-products as
food ingredients and active compounds in human health, e.g. glucosinolates from cauliflower, polyphenols from artichoke, sulforaphane from
broccoli, quercetin from onion, lentinane from shiitake mushrooms, lycopene from tomato, etc.
We can also offer custom extraction of other plants (seaweeds, fruits,
cereals, aromatic herbs, etc.) to our customers.
The laboratory transforms the raw materials into water-soluble powders
for use in the pharmaceutical, cosmetics and food supplement industries.
organic water of several vegetables & fruits are produced by distillation.
Agrival is able to remove the volatile organic compounds to satisfy cosmetic applications (e.g. organic chicory water). In these organic waters,
Agrival can add conservatives (or not) according to the specificity of the
customers.
Agrival produces Shiitake powder, registered as feed materials, enriched in lentinane and eritadenine, and also a higher quality for food
application.
Agrival is developing an aqueous extraction of polyphenols from artichoke. In this case, all parts of the vegetable are used: artichoke heart
in food application, the by-products (leaves) for polyphenol extraction in
nutraceutical application and then the fibers (residue of extraction) for
absorbent properties.
Agrival offers tailor made solutions, according to our equipment, in solvent-free (aqueous) extraction and purification.
young company in progress, AGRIvAl uses a complete extraction process
on 1500m2. our production unit, flexible and efficient, has been designed
in order to satisfy your needs. our team and its know-how are at your service to help you in innovations.
Address
AGRIVAL
Route de mespaul
29420 PloUénAn
FRAnCE
natural is our philosophy: WATER is our unique solvent. our raw materials
are by-products of vegetables and fruits, mainly from northern Finistère.
AGRIvAl has entered into an ecological valorization of local agriculture. vegetables and fruits are purchased from farms, all labeled “Agri-Confiance”.
This certification demonstrates SICA, from Saint Pol-de-léon, controls the
quality and the environment of agricultural production (traceability, good
practice of culture, water management...). That’s the way AGRIvAl can ensure you an optimal traceability and a lowered impact on the environment.
Contact detail
Fabien DAnET
Tel. +33 (0)2 98 15 84 95
contact@agrival-extract.com
www.agrival-extract.com
31
AGROBIO
location
vEZIn lE CoQUET, FRAnCE
Key words
CoSmETICS, nUTRACEUTICAlS, EFFICIEnCy
TESTInG, oRAC vAlUE, STABIlITy STUDIES,
GlyCEmIC InDEX, monAColIn K, STEvIA,
PACS, vITAmInS
FIELDS OF EXPERTISE AND SERVICES OFFERED
From research to the consumer, Agrobio supports you in each step. With
more than 25 years of experience, the laboratory brings you its knowledge
and its expertise in nutrition, food supplements and ingredients.
We possess a high experience in the knowledge of natural products, and in
preparation and extraction processes as well as in the field of the analysis
of nutritionally valuable compounds. We perform the tests and analyses
required and we are able to develop your own analysis procedure.
moreover, laboratories Agrobio can propose a complete service with microbiological, physical and chemical analyses. We provide reliable results
and our laboratory is in compliance with current industry standards (accreditation CoFRAC n°1-1982, ISo 17025). our team is a real technical
backing to offer an adapted solution for the R&D departments, the quality
control and the marketing of the food-processing, pharmaceutical and
cosmetic companies.
Carotenoids : the only CoFRAC accreditation laboratory for lycopen
analysis
Polyphenols and antioxidants: the only CoFRAC accreditation laboratory
for catechin and proanthocyanidines analyses.
vitamins
Antioxidant capacity, oRAC value
monacolinK
Stevia (rebaudiosid A)
Coenzym Q10
B glucans
In vitro glymenic index
Stability studies (according to the ICH guidelines)
Address
AGROBIO
ZAC des 3 marches
3 impasse de la Jonchée
35132 vEZIn lE CoQUET
FRAnCE
Contact detail
Christian nIo
Tel. +33 (0)2 99 14 70 50
Fax : +33 (0)2 99 14 70 51
nio.c@laboratoiresagrobio.fr
www.agrobio-rennes.com
32
ALGENICS
location
SAInT-HERBlAIn, FRAnCE
Key words
mICRoAlGAE, BIoTHERAPEUTICS,
REComBInAnT PRoTEInS, GlyCoSylATIon,
monoClonAl AnTIBoDIES, vACCInES
AlGEnICS is a privately-held biotechnology company focusing on innovative
uses of microalgae to produce recombinant biotherapeutics.
our proprietary platform Algebiosys™ encompasses tools and
technologies specifically developed to ensure high expression level of
recombinant proteins in our PTA microalgal cell line.
our technology offers key competitive advantages :
Enable production of complex proteins, including glycoproteins
Proprietary system for production of biotherapeutics bearing naturally
low fucose glycans
Proprietary system for production of biotherapeutics with terminal
mannose glycans
High quality and homogeneity of n-glycosylation to improve batch-tobatch consistency
Biotherapeutics products in-process can be secreted into the culture
broth or stored within the PTA cells to achieve high amount of
encapsulated product.
The Algebiosys™ technology is available as a platform for the production
of recombinant proteins. We also leverage our technology to identify and
produce biotherapeutics that benefit from our microalgal’s capabilites.
Current targets include monoclonal antibodies and viral envelope
immunogens.
ACCESS PolICy
Algebiosys™ is available through licensing agreement.
Address
ALGENICS
Pôle Bio-ouest
Rue du moulin de la Rousselière
44800 SAInT-HERBlAIn
FRAnCE
Contact detail
www.algenics.com
Alexandre lEJEUnE
33
ATLANCHIM
PHARMA
location
nAnTES, FRAnCE
Key words
CHEmICAl SynTHESIS
CUSTom-mADE FInE CHEmICAlS
SITE-SPECIFIC STABlE ISoToPE lABElInG
French CRo expert in chemical synthesis of complex molecules from
milligram scale to hundred grams, ATlAnCHIm PHARmA Company, your
Reliable Research Partner, provides customized services in the field of fine
organic chemistry.
Depending on your needs, several types of services are available:
Research collaboration,
Custom-made fine chemicals,
Site-specific stable isotope labeling,
medicinal chemistry,
Biological evaluation of the synthesized molecules.
our specificities are the following:
Heterocycle synthesis
Carbohydrate chemistry
Total synthesis of natural products
Peptide synthesis (short chains)
Synthesis of chiral molecules
Synthesis of amino acids, nucleic acids, steroids, alkaloids
our PhD laboratory serves your research with a highly skilled team and the
special support of a senior scientific management.
Hit identification to lead optimization
metabolites Isolation, purification and synthesis of impurities, analytical
standards, reference compounds, intermediates
Representative syntheses:
Synthesis of a library of 40 molecules in 3 to 9 steps
Synthesis of 1g of compound in 20 steps
Address
ATLANCHIM PHARMA
1 rue Gaston veil
FRAnCE
Synthesis of 1g of labeled compound, (13C4 ) in 9 steps
Synthesis of 4.5g of labeled compound, (D11) in 7 steps
ISo 9001 accreditation covering all our activities.
Eligible for Research Tax Credit (CIR)
Contact detail
nolwenn DAUBIn
Tél. +33 (0)2 40 41 29 61
Fax. +33 (0)2 40 41 28 35
Cel. +33 (0)6 29 44 26 10
nolwenn.daubin@atlanchimpharma.com
www.atlanchimpharma.com
34
ATLANTIC BONE
SCREEN
location
nAnTES, FRAnCE
Key words
PREClInICAl SERvICES, BonE, JoInT,
SCREEnInG, In vITRo, In vIvo, HISToloGy,
ImAGERy
HIGH-QUAlITy EXPERTISE In THE FIElD oF BonE AnD JoInT DISEASES
ATlAnTIC BonE SCREEn is a French CRo focusing on bone and joint
diseases and on bone diseases from tumor origin. our company puts at
its customers’ disposal a unique preclinical platform with a wide range
of competitive in vitro and in vivo assays as well as histology and imaging
services.
oUR mISSIon: oPTImIZE AnD ACCElERATE THE DEvEloPmEnT oF
yoUR ComPoUnDS
Atlantic Bone Screen aims to optimize and accelerate the development of
your compounds, allowing you to identify and characterize the therapeutic
potential of your drug candidates, nutraceuticals and biomaterials.
TAIloR-mADE PREClInICAl STUDIES
Atlantic Bone Screen is committed to providing you with tailor-made solutions for your preclinical studies.
We are ISo 9001v2008 certified.
A UnIQUE PREClInICAl PlATFoRm
In vitro Assays – our specialty: Bone and joint cells
We carry out in vitro assays on osteoarticular cells and on tumoral cells
from animal and human origin.
In vivo Assays – Reliable animal models reproducing human bone pathologies.
our company provides you with a broad range of original and relevant
experimental models that reproduce human bone pathologies (osteoporosis, osteoarthritis, rheumatoid arthritis, osteosarcoma, bone metastases,
etc…).
Histology – High Quality Expertise in hard and soft tissues
In addition to in vivo & in vitro assays, we may also provide you with tailormade ex vivo analyses in histology and imaging.
Imaging Services – outstanding equipments for qualitative and quantitative
analyses.
Address
ATLANTIC BONE SCREEN
1 rue Gaston veil
44200 nAnTES
FRAnCE
APPlICATIonS: drug candidates, nutraceuticals, biomaterials, marine
natural products, formulations … for health care, food and cosmetic industries.
Contact detail
Elisabeth PoRCHER
+33 (0)2 40 41 11 25
elisabeth.porcher@atlantic-bone-screen.com
www.atlantic-bone-screen.com
35
BIOFORTIS SAS
A MÉRIEUX NUTRISCIENCES
COMPANY
location
nAnTES, FRAnCE
Key words
Biofortis is CRo specialized in innovation for nutrition:
Expert clinicians and scientists dedicated to nutritional health;
Powerful recruitment capabilities and an integrated central lab with a
focus on probiotics and microbiota analysis.
ClInICAl TRIAl, nUTRITIon, BIoloGICAl
AnAlySIS, mICRoBIoTA, PRoBIoTIC,
GEnoTyPInG
Clinical study: multi-parameter technical facilities (Biochemistry,
immunology, hematology, HPlC...) targeting biomarkers in the field of
bones mineralization, cardiometabolism, inflammation, satiety...
microbiota analysis: QPCR, Fingerprinting (DHPlC)
microorganisms genotyping: RAPD, Rep-PCR, Delta-PCR
ACCESS PolICy
BIoFoRTIS, as a private company, keeps the possibility of modulating the access
according to the demand or to the applicant.
Address
BIOFORTIS SAS
3 route de la Chatterie
44800 SAInT HERBlAIn
FRAnCE
Contact detail
Anne-laure CARDoU
www.merieuxnutrisciences.com
anne-laure.cardou@mxns.com
36
BIOPREDIC
INTERNATIONAL
BIOPREDIC
INTERNATIONAL
location
REnnES, FRAnCE
Biopredic International is a worldwide supplier of human and animal
primary cells, cell lines and tissues for research, drug discovery, drug
development, pharmacology and toxicology. Biopredic was established in
1993 and has worldwide operations.
Key words
HEPARG CEllS, HEPAToCyTES, HUmAn
SKIn, RESEARCH REAGEnTS, ToXIColoGy,
TISSUES, FlUIDS, DRUG ASSAyS
Cryopreserved HepaRG cells and human hepatocytes for metabolism,
transporters, in vitro toxicology and genotoxicity studies. Plasma and
human fluids for bioanalysis and biomarker studies. Customized tissue
acquisitions.
ACCESS PolICy
Any request can be e-mailed via our website or by email directly at the sales
department
Customers: industry and academics
Address
BIOPREDIC
8-18 rue Jean Pecker
35000 REnnES
FRAnCE
Contact detail
Christophe CHESnE
Tel. +33 (0)2 99 14 36 14
Christophe.chesne@biopredic.com
www.biopredic.com
37
BIOTRIAL
location
REnnES (HQ), nAnTES, PARIS, FRAnCE
lonDon, UK
BRUSSElS, BElGIUm
nEWARK, nJ. USA
Key words
non ClInICAl & ClInICAl STUDIES,
onColoGy, PATIEnTS, CoRE lAB, EARly
DEvEloPmEnT, PHASE I TRIAlS, PHASE II-Iv
STUDIES, DATA mAnAGEmEnT, BIoSTATISTICS, mEDICAl WRITInG
Biotrial is a leading full-service provider specialized in Early Development
with a large range of services from non-Clinical Pharmacology to Proof of
concept studies.
our services include:
non-clinical in vivo pharmacology (Safety & Discovery models)
Phase I clinical pharmacology trials
Data management, Biostatistics and medical Writing
management Conduct of phase II-III trials and oncology studies
Core lab services: centralized ECG reading, Imaging, cognitive
assessments, central lab, EEG, PSG.
Regulatory Affaires & QA
Access to highly specialised equipment, pathology experts, patient
population, healthy volunteers, etc as we have a close collaboration with
hospitals (all Biotrial units are based inside hospital areas).
ACCESS PolICy
Requests can be sent by e-mail to contact@biotrial.com. They will be automatically
received by the Business Development Department, who will respond accordingly.
Address
BIOTRIAL
7-9 rue Jean louis Bertrand
Technopole Atalante villejean
35000 REnnES
FRAnCE
Contact detail
Julie REmy
Tel. +33 (0)2 99 59 91 91
Julie.remy@biotrial.com
www.biotrial.com
38
C.RIS PHARMA
location
SAInT-mAlo, FRAnCE
Key words
PREClInICAl DEvEloPmEnT, In vIvo,
In vITRo
C.RIS Pharma is a GlP and ISo 9001certified independent biotechnology
company.
We have developed strong partnerships within the pharmaceutical,
cosmetic and food industries.
our scientific expertise in the setting up and surveillance of a range of
services in the domain of health and safety enables us to offer support
for the development of your active principles and ensure their efficiency
as well as their innocuity. We have expertise in the fields of cancer,
neurodegenerative disease, metabolic and genetic diseases, agrifood and
cosmetics.
our studies are performed in compliance with the national and
international guidelines and the principles of Good laboratory Practice.
Efficacy assays (in vitro and in vivo models; cancer, diabetes, obesity,
inflammation, Alzheimer,…)
Pharmacology and regulatory toxicology
Bioanalytical analyses
Address
C.RIS PHARMA
Parc Technopolitain
Atalante Saint-malo
35400 SAInT-mAlo
FRAnCE
Contact detail
Pierrick AUvRAy
Tel. +33 (0)2 99 19 69 70
contact@c-rispharma.com
www.c-rispharma.com
39
CARLINA
TECHNOLOGIES
location
AnGERS, FRAnCE
Key words
DRUG DElIvERy, EnCAPSUlATIon,
nAnomEDICInES, mICRomEDICInES, DRUG
TARGETInG, PRoTEIn DElIvERy, SUSTAInED
RElEASE, BIoTHERAPEUTICS ConTRollED
DElIvERy
CARlInA Technologies is a biopharmaceutical company specialized in the
development of micro and nanomedicines utilizing innovative drug delivery
technologies.
The company develops improved pharmaceutical versions of first
generation drugs, or drug candidates under development, in order to
increase their efficacy and safety.
CARlInA Technologies provides both formulation development services
and product development partnerships with out-licensing opportunities to
the pharmaceutical, veterinary and biotechnology industries.
CARlInA Technologies develops innovative micro and nanomedicines
using its proprietary technologies Soludots and Peptidots, two
encapsulation technologies for poorly water-soluble drugs and
biotherapeutics, respectively.
Additionally, CARlInA can provide R&D formulation services using lipidots,
a CEA’s (French Alternative Energies and Atomic Energy Commission)
proprietary DDS platform.
Address
CARLINA TECHNOLOGIES
22 rue Roger Amsler
49100 AnGERS
FRAnCE
Contact detail
olivier mEyER
www.carlinatech.com
omeyer@carlinatech.com
40
CEVA
location
PlEUBIAn, FRAnCE
Key words
AlGAE, SEAWEED, mICRoAlGAE,
HAloPHyTIC PlAnTS, mARInE
PHAnERoGAmES, mARInE BIoTECHnoloGy,
EXTRACTIon, PURIFICATIon,
CHARACTERIZATIon, ACTIvE ComPoUnD,
InGREDIEnT, AlGAl CUlTIvATIon,
AQUACUlTURE
CEvA is the only technical center of its kind in Europe. It supplies services
to companies designing and developing industrial products based on marine ingredients (seaweeds, microalgae, marine plants, sea water) and to
local authorities confronted with the massive growth or drifts of seaweed
and marine plants.
Combining high level knowledge in ecology, biology and chemistry, CEvA
is a unique place to design cross technology projects using algae as raw
material. For instance specific algae culture can be set to produce high
value molecules extracted with precise chemical process and a clear view
on environmental interactions.
one example of this skill is the IDEAlG project constructed with the CnRS
(the French national Centre for Scientific Research). It has had a budget
of 45 m€, mostly public funds, over several years to develop algae applications.
Another example is a 700 K€ totally private project to develop new active
ingredients.
yet another example is a biotechnology made oligo-saccharide integrated
as cosmetic active ingredient since almost 10 years with >10 m€ market
value for our partner. Beside our internal capabilities, we also activate our
broad network related to algae business when necessary.
ACCESS PolICy
CEvA can work worldwide in any location interested by marine algae and seaweed.
As a private company, we provide contracted research directly to companies. We
can also be integrated as partner or leader in collaborative R&D supported by
public funds or private consortium.
Address
CEVA
Presqu’île de Pen lan
BP 3
22610 PlEUBIAn
FRAnCE
Contact detail
marc DAnJon
Tel. +33 (0)2 96 22 93 50
algue@ceva.fr
www.ceva.fr
41
CLEAN CELLS
S.A.S.
location
BoUFFéRé, FRAnCE
Key words
GlP/GmP QUAlITy ConTRol lABoRAToRy
FoR BIoPHARmACEUTICAl PRoDUCTS
(AnTIBoDy, REComBInAnT PRoTEIn, CEll
AnD GEnE THERAPy…)
Clean Cells is an international company, expert in biosafety testing and the
characterization of biological products. our GlP certification and a deep
knowledge of the latest regulatory requirements (FDA, European Pharmacopoeia …) enable us to be a reliable partner for all actors of the biotech
industries to whom we offer a large range of innovative services from
research to clinical GmP biomanufacturing.
We work in conformity with GlP and have been recently audited and successfully certified for GmP activities. We are certified ISo 9001.
our global integration of services allows us to benefit from a high reactivity for custom assay development (less than 3 months) and an overall
operational efficiency thanks to our project managers well-versed in innovative technologies.
our main field of business are:
GlP and GmP testing and characterisation of cell banks, in process
products and final products
GlP and GmP viral clearance study
GmP cell banking and storage
Potency assays (bioassays, interferon)
Transfer and/or development of customised cell based or molecular
biology
Assay validation according to ICH guidelines.
We mainly work for the following areas:
Gene therapy,
Cell therapies,
Therapeutics bioproducts ( mab and recombinant protein),
Stem cell therapies.
Address
CLEAN CELLS SAS
Parc d’Activité vendée Sud loire 1
Rue marie Curie
85600 BoUFFéRé
FRAnCE
Contact detail
olivier BoISTEAU
Tel. +33 (0)2 51 09 27 57
oboisteau@clean-cells.com
www.clean-cells.com
42
HITEX
location
vAnnES, FRAnCE
Key words
FUll-SERvICE In EXTRACTIon,
FRACTIonATIon, PURIFICATIon,
SUPERCRITICAl Co2, SUBCRITICAl WATER,
ETHAnol EXTRACTIon, DEvEloPmEnT,
PRoDUCTIon
As your industrial partner, Hitex offers its expertise and know-how in
clean extraction technologies permitting your projects to become market
successes.
our expertise in all supercritical Co2 and processes : extraction,
fractionation, separation, purification, impregnation and formulation enable
us to provide effective support throughout your project:
In R&D: the development of new products and processes, starting from
liquid or solid materials.
Scale-up and production: cost effective solutions by using supercritical
Co2 , subcritical water, avoiding the use of organic solvents
Technical support: improvement of processes, including problem-solving
in purification, decoloration.
our business sectors include perfumes/ aromas, cosmetics,
nutraceuticals, the biomedical industry, pharmaceuticals, phytotherapy
and chemistry.
Customer projects are managed under confidentiality.
We manage the projects more than only the extraction itself.
our expertise in concentrated on technologies but also on the other
aspects of the project: operations before the extraction (grinding, milling),
wastes management, operations on the extracts: filtration, decoloration,
drying, formulation, packaging, quality control, certification, analysis (HPlC,
GC)
Projects include more and more added value through specific
combinations of technologies, multiple step processes done in Hitex. It
allows to reduce costs (full service), simplify project management and
speed up developments.
Address
HITEX
Rue louis lefèvre Utile
Pentaparc
BP 33601
56036 vAnnES - FRAnCE
Ultimate equipment investments concern liquid extraction by supercritical
Co2, subcritical water extraction and added capacity in water and ethanol
extraction.
Contact detail
Irène lAmoUR
Tel. +33 (0)2 97 68 88 88
contact@hitex-co2.com
www.hitex-co2.com
43
HPC PHARMA
location
REnnES, FRAnCE
Key words
oRGAnIC CHEmISTRy, HIGHly PoTEnT
ComPoUnDS, CUSTom SynTHESIS,
FEASIBIlITy STUDIES, DEvEloPmEnT
SUPPoRT, APIS SynTHESIS &
DEvEloPmEnT
HPC Pharma (Highly Potent Custom Pharmaceuticals) is a business unit
specialized in the custom synthesis of active pharmaceutical and cosmetic
ingredients.
HPC Pharma offers services in:
Production of highly potent organic molecules (100mg to 100g)
Feasibility studies
Development support
Production, characterization, purification and identification of impurities
and reference compounds.
HPC Pharma has several years of experience in handling highly active
compounds (we have the appropriate facilities and equipment) and
collaborates closely with academia.
Cytotoxic drugs, innovative APIs, Generics, oncological molecules…
ACCESS PolICy
open to all pharma companies, biotech companies, fine chemicals companies,
Cmo, CRo.
Academic labs that require specific highly potent chemicals.
Address
ENSCR
Avenue du Général leclerc
CS 50837
35708 REnnES Cedex 7
FRAnCE
Contact detail
yazan El SAFADI
Tel. +33 (0)2 23 23 81 21
yazan.elsafadi@hpc-pharma.com
www.hpc-pharma.com
44
ID.MER
location
loRIEnT, FRAnCE
Key words
DEvEloPmEnT, mAnUFACTURInG,
ConSUlTAnCy, SEA PRoDUCTS,
FISHERy By-PRoDUCTS, EXPloITATIon,
BIoTECHnoloGy
ID.mer contributes to the development and promotion of the sea product
industry:
Coordination of cooperation between scientific and technical research
and the sea product industry
Pilot trials for optimizing sea products processing techniques: design,
innovation, development
Information, dissemination, technology watch, transfer of knowledge,
consultancy
Exploitation of marine by-products in the human and animal health and
nutrition sectors.
Development of finished products: smoked products, marinated fish,
ready-to-eat meals, canned food, frozen foods, delicatessen etc.
Industrial pre-runs.
Fishery by-products value upgrading.
Development of Intermediary Food Products, ingredients for cosmetics
and nutraceutics industries.
Design of new factories or extension of existing factories.
ACCESS PolICy
membership, request for price quote
Address
ID.MER
2 rue Batelière
56100 loRIEnT
FRAnCE
Contact detail
Pascal lARnAUD
Tel. +33 (0)2 97 83 86 83
contact@idmer.com
www.idmer.com
45
IN-CELL-ART
location
nAnTES, FRAnCE
Key words
AnTIBoDy, vACCInE, ImmUnIZATIon,
InFECTIoUS DISEASE, PRoTEIn, REAGEnT,
TRAnSFECTIon, DRUG DISCovERy
Antibody generation: our Research team including a nobel laureate
has designed a technology of nanocarriers that allows the most
efficient antibody generation. We have designed more than 200
antibodies in less than 2 years for major pharmaceutical companies
and academic reseachers (Sanofi, merial, Geneuro, Inserm...). Without
the recombinant antigen and simply starting from your in silico DnA
sequence we provide the most ambitious antibodies with the best
affinity.
vaccine Development: our know-how at the nano scale and our
technology of adjuvants are real breakthrough for DnA and subunit
vaccines. These adjuvants are currently being tested by major vaccine
companies. They offer unique efficient and industrial features as well as
excellent safety profile.
Transfection reagents: We manufacture new classes of Transfection
reagents, ICAFectin. They are becoming the reagents of choice for DnA
and siRnA. They provide the best protein expression or gene silencing
level in almost any cell lines even hard to transfect cells such as primary
and embryonic stem cells.
Antibody generation: In-Cell-Art technology allows functional antibodies
generation against any natively expressed nuclear, cytoplasmic, secreted
or membrane proteins. Customer only provides the access number of the
antigen.
Address
IN-CELL-ART
1 place Alexis Ricordeau
FRAnCE
Contact detail
Benoit BARTEAU
Tel. +33 (0)2 40 71 67 17
Fax: +33 (0)2 28 08 00 36
benoit.barteau@incellart.com
Examples of application:
nuclear: Transcription factors from Drosophila, Saccharomyces, Homo
sapiens...
Intracellular: GAG from retrovirus, Galactosidase from bacteria...
membrane Human CD20 and CD22, Ionic Channel from rat, leucocyte
Antigen from Swine, HA from influenza virus, Hormone receptors
(GPCR) from mouse...
Secreted: Human metabolism related protein, EPo from dog, Pituitary
hormone...
vaccine development: In-Cell-Art nanocarriers have been tested
successfully on mice having an induced-Hepatocellular Carcinoma
(HCC). This is the first DnA vaccine effective against HCC.
Transfection Reagents: many studies are published in high impact
factor journals: Journal of Biological Chemestry, nucleic Acids
Research, PloS onE, Human Gene Therapy, PloS Pathogen, Journal of
neurochemistry...
ACCESS PolICy
In-Cell-Art sells transfection reagents, works as fee of service and also grants
licence to its nanocarriers and obtain upfront payment and royalties payment on
net sales.
www.incellart.com
46
MYELOMAX
location
nAnTES, FRAnCE
Key words
mUlTIPlE myElomA, DRUG EFFICIEnCy,
myElomA CEll lInES, In vITRo STUDy
our mission is to assist our clients in the evaluation of drug efficiency,
mechanism, identification of biomarkers in multiple myeloma, a cancer
that allows introduction of new types of therapeutic molecules for
treatment of cancers (proteasome inhibitors, immunomodulators).
We offer to pharmaceutical industry and biotechnology companies
studies that are mainly conducted in vitro, thus are low cost and no time
consuming using our collection of Human multiple myeloma Cell lines
representative of multiple myeloma heterogeneity.
multiple myeloma has a molecular heterogeneity which impacts the
response to treatments and overall survival.
our well characterized collection provides a unique tool to study drug
efficiency with respect to multiple myeloma heterogeneity and allows
identification of biomarkers linked to drug responses.
myelomax offers to pharmaceutical industry and biotechnology companies
studies that are mainly conducted in vitro, thus are low cost and no time
consuming.
Evaluation of therapeutic potential of (new) agents in multiple myeloma
Expertise anti-tumoral activity of agents
Define either the IC50 or the lD50
Compare the efficiency to the one of approved drugs
Define efficiency with respect to multiple myeloma biodiversity
Define efficiency in clonogenic growth assay
Define efficiency in tumorogenic growth in immunocompromised mice
Dissection of cellular mechanisms induced by therapeutic agents
Signalling pathways (mAPK, AKT…)
Characterization of cell death (apoptosis, Bcl2 family molecules)
Address
IRT-UN
8 quai moncousu
FRAnCE
Contact detail
Emmanuel mEnoRET
www.myelomax.com
e.menoret@myelomax.com
47
POLYMARIS
BIOTECHNOLOGY
location
moRlAIX, FRAnCE
Key words
BlUE BIoTECHnoloGy, mARInE BIomolECUlES, mICRo-oRGAnISmS, EXoPolySACCHARIDES, BIoFERmEnTATIon
Polymaris Biotechnology is a specialist in the discovery, characterization
and exploitation of novel marine biomolecules.
our focus is on exopolysaccharides produced by bacteria from the
company’s private collection of marine micro-organisms (which currently
contains over 800 strains).
Polymaris is now leveraging these strains to develop over ten entirely
novel, pure, fully-characterized biomolecules. It also offers custom
hemisynthesis involving these compounds.
The target markets for industrial application of these biodegradable,
natural compounds are nutraceuticals, fine chemicals, environment,
agrifood, cosmetics, dermocosmetics and healthcare.
Discovery of new biomolecules by innovative microbiology techniques.
Production by fermentation processes: 500 ml to 30 000 l.
Purification of natural biopolymers.
Chemical characterization: Gaz chromatography, HPlC, HPsec…
marine exopolysaccharides as innovative active ingredients for cosmetic
applications.
ACCESS PolICy
Industrial collaborations.
Address
POLYMARIS
Aéropôle Centre
29600 moRlAIX
FRAnCE
Contact detail
Anthony CoURToIS
Tel. +33 (0)2 98 88 04 57
contact@polymaris.com
www.polymaris.com
48
VEGENOV
location
SAInT Pol DE lEon, FRAnCE
Key words
BIoTECHnoloGy, PlAnT DISEASES,
BREEDInG, nEW PlAnT CUlTIvARS,
QUAlITy, SEnSoRy EvAlUATIon, EXPERT
AnAlySIS, TRAInInG, ConSUlTAnCy
vegenov offers more than 20 years of experience on plant research and
development and is particularly specialized in plant biotechnology and
pathology, as well as sensory and nutritional quality.
vegenov proposes a full range of services for plant breeders, seed
companies, agrochemists, growers and distributors.
our main fields of expertise are:
Plant breeding: evaluation of genetic diversity of collections, markerassisted selection, tissue culture techniques, screening for disease
resistances and sensory quality criteria.
Crop protection: evaluation of phytosanitary products (plant elicitors,
disinfectants for greenhouses and tools, pesticides,…), alternative crop
protection approaches, pathogen detection.
Plant product quality: evaluation of sensory and nutritional quality of
plant products, DnA fingerprinting (quality control, fraud detection,
litigation resolution,…).
Project support: expert market and technology analysis, project set-up
and coordination, training.
The technologies currently available in vegenov are:
molecular biology techniques: isolation of DnA and RnA from various
samples (robotic workstations), PCR, quantitative RT-PCR, High
Resolution melting (HRm) analysis.
Cell biology and tissue culture techniques: haplomethods, embryo
rescue, micropropagation, somatic embryogenesis, somatic
hybridization.
Plant pathology techniques: inoculum production, pathogen inoculation,
pathogenicity test, phenotyping and scoring scales. vegenov has
a specific new laboratory for quarantine pathogens (including two
climatized growth chambers).
Sensory and nutritional quality analyses: discrimination and descriptive
(profile) tests with specific trained panels on vegetables, CG-mS and
HPlC analyses of various compounds including glucosinolates, inulin, …
ACCESS PolICy
Address
VEGENOV
Penn Ar Prat
29250 SAInT Pol DE lEon
FRAnCE
As not-for-profit organization, vegenov provides customized and confidential
projects for worldwide companies interested in plant research and development.
As a coordinator or a partner, we are also involved in numerous collaborative
R&D projects bringing together private companies and public research
organizations.
Contact detail
Serge mABEAU
Tel. +33 (0)2 98 29 06 44
contact@vegenov.com
www.vegenov.com
49
VIVALIS SA
location
nAnTES, lyon - FRAnCE
ToyAmA - JAPAn
Key words
FUlly HUmAn AnTIBoDy DISCovERy
PlATFoRm, EB66® CEll lInE, vACCInES,
ADCC
vIvAlIS is a biopharmaceutical company that provides innovative cellbased solutions to the pharmaceutical industry for the manufacture
of vaccines and proteins, and develops drugs for the prevention and
treatment of unmet medical needs.
vivalis provides discovery and development solutions for biopharmaceutical
programs. our leading platforms that include the vIvA|Screen™ human
monoclonal antibody discovery platform and the EB66® cell line are the
subject of multiple partnerships throughout the world.
our contract manufacturing group provides GmP manufacturing services
for vaccines, monoclonal antibodies, and recombinant proteins from
preclinical to Phase II requirements from cell banks to 500 l fermentation.
vIvAlIS has established nearly 30 licenses issued to date with world
leaders, such as Sanofi Pasteur, GlaxoSmithKline, Pfizer, Kaketsuken,
merial, Intervet, SAFC Biosciences.
The vIvA|Screen™ discovery platform for the identification and isolation of
fully-human mAbs via a High-Throughput Screening to isolate and identify
native human B-cells that express mAbs of interest and clone them from
single cells.
Under partnership agreements, vivalis can also provide complementary
services for stable cell line development up through Phase II GmP
manufacturing.
The EB66® cell line is a duck-derived, embryonic stem cell that can be
used for the production of both human and animal vaccines. Today, 2
products manufactured in EB66 are in clinical development (Phase I in
US and Phase II in Japan respectively).
The EB66® cells can be used for the production of monoclonal
antibodies (mAbs). A natural property of the cell line is its ability to
defucosylate antibodies, thereby enhancing the ADCC. Their doubling
time of less than 13 hours and their ability to grow to high cell densities
(up to 5 x 107 cells/ml), make EB66® cells an attractive alternative to
traditional production technologies.
ACCESS PolICy
Address
VIVALIS SA
Campus Bio-ouest
6 rue Alain-Bombard
44821 SAInT-HERBlAIn Cedex, nAnTES
FRAnCE
vIvA|Screen™: vivalis offers an access to its platform for the discovery of fully
human mAbs under both non-exclusive and exclusive license agreements for
commercial use or under partnership agreements with a full integrated services
from the discovery to the mAb release through stable cell line development under
GmP manufacturing.
EB66® : vivalis offers EB66® cells under both non-exclusive and exclusive license
agreements for research or commercial use.
Contact detail
Franck GRImAUD
www.vivalis.com
franckgrimaud@vivalis.com
50
IRElAnD
PROTEOMICS
AND MASS
SPECTROMETRY
NICB
(DUBLIN CITY UNIVERSITY)
The national Institute for Cellular Biotechnology (nICB), located at DCU,
houses a state-of-the-art Proteomics and mass Spectrometry Core Facility
that provides support to many research programmes within the nICB, and
non-nICB programmes in DCU and externally.
Sample preparation from various biological materials (e.g. cell lines,
location
DUBlIn, IRElAnD
Key words
SPECTRomETRy, PRoTEomICS,
BIoTECHnoloGy, oRoTEIn
CHARACTERIZATIon, 2D GEl
ElECTRoPHoRESIS
conditioned media, serum, plasma, vitreous fluid, urine).
2D Difference Gel Electrophoresis
Quantitative lC-mS proteomics (including label (e.g. SIlAC) and labelfree)
mAlDI ToF mS for peptide mass fingerprinting
lC-mS/mS using lTQ-ETD and lTQ-orbitrap (high mass accuracy)
Protein characterisation (e.g. phosphorylation)
Equipment for protein separation using 2D gel electrophoresis (IPGphor,
Ettan Dalt 6 and 12 units)
Typhoon 9400 fluorescent imager
Robotics for sample picking and digestion from gels (Ettan Picker, Ettan
Digestor and Ettan mAlDI Spotter robots)
2D differential analysis software (Decyder, Progenesis SameSpots)
Protein identification (mASCoT, SEQUEST/Proteome Discoverer,
PEAKS)
lC-mS label-free analysis software (nonlinear Dynamics)
Address
NATIONAL INSTITUTE
FOR CELLULAR BIOTECHNOLOGY
Dublin City University
DUBlIn
IRElAnD
Akta Prime system (GE Healthcare)
lTQ ion trap equipped with ETD (Thermo Fisher Scientific)
lTQ-orbitrap Xl (Thermo Fisher Scientific)
4800 Plus mAlDI-ToF ToF (AB Sciex)
Ettan Pro mAlDI ToF (GE Healthcare)
Contact detail
nATIonAl InSTITUTE FoR CEll
BIoTECHnoloGy
Glasnevin
DUBlIn 9
IRElAnD
SElDI ToF PBSIIc
Ultimate 3000 nano lC (Dionex)
ACCESS PolICy
Access is available internally, through collaborations with external institutions, and
provision of external services. Booking system in operation.
Paula mElEADy
Tel. +353-1-7005910
Fax: +353-1-7005484
paula.meleady@dcu.ie
www.dcu.ie
52
EXPRESSION
FACTORY
VECTOR CONSTRUCTION,
PRIMERS & TEMPLATES
(UNIVERSITY COLLEGE DUBLIN)
location
DUBlIn, IRElAnD
Key words
The Expression Factory (EF) Facility provides a parallel solution to the
problems associated with protein expression. With a unique combination
of biology, software and instrumentation, the system fully automates and
integrates the processes involved. vector construction, protein expression
and purification are performed within a single platform.
The EF has a capacity of a maximum of 384 reactions per run (different
process chains have different limitations). It can take up to 19 input plates
(e.g. PCR - 19 plates containing Primers & templates).
SUBClonInG, EXPRESSIon vECToRS,
mUTAGEnESIS
CRS robotic arm
Sias Xantas liquid handling system comprising of 8 channel pipettes
Automated plate handling
Four plate positon thermocyclers
Cytomat for cell growth and monitoring
Sias two plate centrifuge system
Filtration station
‘Smart Trough’ system for purification and recovery
ACCESS PolICy
The EF is open to academic and industry projects in Ireland as well as worldwide.
Address
EXPRESSION FACTORY FACILITY, UCD
Conway Institute, University College Dublin
Belfield
DUBlIn 4
IRElAnD
Contact detail
Alejandro mERIno
Tel. +353 1 716-6983
alejandro.merino@ucd.ie
www.ucd.ie
53
MSR
CONWAY MASS SPECTROMETRY
RESOURCE AND PROTEINS
SEPARATIONS LABORATORY
location
DUBlIn, IRElAnD
Key words
SPECTRomETRy, PRoTEomE RESEARCH
CEnTRE, BIoInFoRmATICS, PRoTEIn
SEPARATIonS, SAmPlE PREPARATIon,
nAnoToXIColoGy
The mass Spectrometry Resource (mSR) and Protein Separations
laboratory is a state-of-the-art facility which was established in 2004 and
supports the proteomics research carried out at the Proteome Research
Centre within the UCD Conway Institute, with the aim of identifying proteins
and their modifications that play important roles in fundamental biology in
health and disease.
The facility is however open to users worldwide and provides the
necessary expertise for planning appropriate experimental strategies,
correct sample preparation and timely execution of analytical workflows.
Complex projects and innovative approaches are also considered on a
collaborative basis.
Planning appropriate experimental strategies
Correct sample preparation
Timely execution of analytical workflows
A proteomic bioinformatics pipeline allows the rapid extraction of
biologically meaningful data from the remarkable amount of data
generated
Two Thermo Fisher lTQ ion traps,
Thermo Fisher lTQ-orbitrap,
Agilent 6520 Quadrupole-ToF and Agilent 6460 Triple Quadrupole
ABI 4800 Plus mAlDI/ToF-ToF
Bruker HCTultra ETD Ion Trap mass spectrometers
Equipment for 1-D and 2-D gel electrophoresis
Image scanners, including a three colour laser fluorescence scanner
(Typhoon).
Address
CONWAY MASS SPECTROMETRY
RESOURCE
& Proteins Separation laboratory
University College Dublin
Belfield
DUBlIn 4
IRElAnD
ACCESS PolICy
Access is available internationally, collaboration projects encouraged, provision of
external services, and online booking is offered.
Contact detail
Giuliano ElIA
Tel. +353 1 7166968
giuliano.Elia@ucd.ie
http://msr.ucd.ie
54
PHOTONICS
RESEARCH
LABORATORY
CRANN
(TRINITY COLLEGE DUBLIN)
location
DUBlIn, IRElAnD
Key words
nonlInEAR oPTICS, UlTRAFAST oPTICS,
nEAR-FIElD oPTICS, RAmAn, DUAl
WAvElEnGTH PUmP-PRoBE SySTEm,
TRAnSIEnT ABSoRPTIon SPECTRoSCoPE,
lASER ABlATIon & DEPoSITIon
nonlinear optics
Ultrafast optics
near-field optics
Raman
The Photonics Research laboratory supports research projects in dual
wavelength pump-probe system, transient absorption spectroscope, laser
ablation & deposition, reflection anisotropy spectroscopy, optical limiting,
Z-scan, resonant Plasmon field enhancement, carbon nanotube analysis
and graphene analysis by Raman Spectroscopy and Raman/Fluorescence
imaging on QD.
This technology platform also contributes to the nanophotonics Research
Strand of the InSPIRE (Integrated nanoscience Platform for Ireland)
consortium.
ACCESS PolICy
Internal access, access through external collaborations, and for service provision
externally.
Address
CENTRE FOR RESEARCH ON ADAPTIVE
NANOSTRUCTURES AND NANODEVICES
Trinity College Dublin
DUBlIn 2
IRElAnD
Contact detail
Jing Jing WAnG
Tel. +353 1 8964617
jjwang@tcd.ie
www.crann.tcd.ie
55
NMR
BIOLOGICAL NUCLEAR MAGNETIC
RESONANCE
location
DUBlIn, IRElAnD
Expertise for collaborative research in biological nuclear magnetic
Resonance is provided as appropriate. This laboratory does not determine
protein structures however proteins are studied by a range of procedures
Key words
nmR, PHoSPHoRylATED PRoTEInS,
mETABolomICS, 3D STRUCTURE
varian 600mHz nmR
Bruker Avance III 500 mHz nmR
Bruker 300 mHz nmR
ACCESS PolICy
Internal access, access through external collaborations, no service provision
externally.
Address
UNIVERSITY COLLEGE DUBLIN
Belfield
DUBlIn 4
IRElAnD
Contact detail
J.p.g mAlTHoUSE
Tel +353 1 7166872
j.paul.g.malthouse@ucd.ie
www.ucd.ie
56
METABOLOMICS
FACILITY
UCD INSTITUTE OF FOOD AND
HEALTH
location
DUBlIn, IRElAnD
The metabolomics facility has considerable expertise in acquiring, analysing and interpreting metabolomics data.
Current research focuses on the use and development of metabolomics
in nutritional research. The group have successfully developed a method
to identify metabotypes which show positive responses to dietary interventions and will develop this further in the context of personalised health.
Identification of biomarkers of health and food intake is also a major focus
of research.
Key words
mETABolomICS, FooD AnD HEAlTH,
mETABoTyPES, mETABolomICS In
nUTRITIonAl RESEARCH, PERSonAlISED
HEAlTH, IDEnTIFICATIon oF BIomARKERS
600 mHz varian nmR machine
Agilent GC-mS
nmR processing software: in house and commercially available
multivariate data analysis software
ACCESS PolICy
externally.
Address
UCD RESEARCH
Belfield
DUBlIn 4
IRElAnD
Contact detail
lorraine BREnnAn
Tel. +353 1 7616759
lorraine.brennan@ucd.ie
www.ucd.ie
57
MR COMPATIBLE
EEG LABORATORY
TCIN
location
DUBlIn, IRElAnD
Key words
ElECTRoEnCEPHAloGRAPHy,
nEURoloGy/nEURoSCIEnCE, CoGnITIvE
DEClInE
The mR compatible Electroencephalography (EEG) Facility has a particular
interest in collaborative translational research opportunities with clinicians
in the area of neurology/neuroscience.
BrainAmp mR 32 PlUS Channel System
Brain vision Recorder First license
Brain vision Analyzer First license
Analyzer Additional license
BrainCapmR 32
SyncBox for Scanner
Power Pack (Rechargeable battery pack)
CmS20EP Digitizer + ElGuide Software + Floor Stand Electrode
placement measuring system
laptop computer (from Brain vision UK)
Consumables starter kit
Current Research Portfolio
ACCESS PolICy
externally.
Address
TCIN, LLOYD INSTITUTE
Trinity College
DUBlIn 2
IRElAnD
Contact detail
Ian RoBERTSon
Tel +353 1 8968935
neuroscience@tcd.ie
neuroscience.tcd.ie
58
PEPTIDE SYNTHESIS
LABORATORY
(RCSI)
location
DUBlIn, IRElAnD
The RCSI Peptide Synthesis laboratory is dedicated to the synthesis,
modification and labelling of peptides and peptidomimetics. The objectives
of this facility are to provide an expertise in peptide chemistry and to
support projects requiring the synthesis of peptides and their modification.
Key words
PEPTIDE SynTHESIS, PEPTIDE-DRUG
ConJUGATES, mIToCHonDRIAl APoPToTIC
PATHWAy, PRoDRUG DElIvERy
The facility is equipped with 3 automated (solid phase) peptide
synthesisers (2 Applied Biosystems 433A and 1 parallel synthesiser
Advanced ChemTech 396), 3 automated HPlC systems using reversephase and size-exclusion chromatography, on analytical and semipreparative scales and 3 freeze-dryers.
ACCESS PolICy
Internal access, access through external collaborations, and for service provision
externally.
Address
PEPTIDE SYNTHESIS LABORATORY
Royal College of Surgeons in Ireland,
123 St Stephens Green
DUBlIn 2
IRElAnD
Contact detail
marc DEvoCEllE
Tel +353 1 402 2176
mdevocelle@rcsi.ie
www.ucd.ie
59
CONFOCAL
MICROSCOPY
FACILITY
The Confocal microscopy Facility supports projects which focus on the
analysis of neuronal cell function (Prof veronica Campbell, Prof marina
lynch and Prof Kumlesh Dev at TCIn).
TRINITY COLLEGE INSTITUTE OF
NEUROSCIENCE, (TCD)
location
DUBlIn, IRElAnD
Zeiss 510 mETA laser scanning confocal microscope
neurodegeneration, neuroprotection & neurorepair
Key words
ConFoCAl mICRoSCoPy, lASER
SCAnnInG, nEURoDEGEnERATIon,
PSyCHIATRIC DISEASES,
PlASTICITyCoGnITIon
Brain aging
Psychiatric diseases & drug abuse
learning, memory & cognition
neural development & plasticity
ACCESS PolICy
externally.
Address
TRINITY COLLEGE DUBLIN
CollEGE GREEn
DUBlIn 2
IRElAnD
Contact detail
veronica CAmPBEll
Tel. +353 1 8961192
vacmpbll@tcd.ie
www.tcd.ie/neuroscience/research
60
ABCRF
MASS SPECTROMETRY RESOURCE
(UNIVERSITY COLLEGE CORK)
location
CoRK, IRElAnD
Key words
mASS SPECTRomETRy, PREP-HPlC,
QUAlIFICATIon, QUAnTIFICATIon
The ABCRF mass Spectrometry laboratory supports a broad range of
research including the characterisation of novel compounds; identification
of unknowns in a known matrix; impurity profiling of a process or mixture;
collection of significant quantities of new impurities for further analysis
Waters micromass Quattro micro triple quadrupole mass
spectrometer
Waters 2695 HPlC separations module with 996 PDA detector x 2
Waters micromass lCT Premier mass Spectrometer
Waters Prep HPlC pump, dual absorbance detector and fraction
collector
An automated Prep-HPlC collector
ACCESS PolICy
externally.
Address
ANALYTICAL & BIOLOGICAL CHEMISTRY
RESEARCH FACILITY
Cavanagh Pharmacy Building
U.C.C. College Road
CoRK
IRElAnD
Contact detail
Florence mCCARTHy
Tel +353 21 4901695
f.mccarthy@ucc.ie
chemweb.ucc.ie
61
TCHPC
HIGH PERFORMANCE COMPUTING
The TCHPC has expertise in specifications capture; infrastructure and systems design; bespoke software development; procurement; user interface
design; management of regulatory requirements (e.g. data protection);
location
DUBlIn, IRElAnD
quality assurance testing; genetic analysis packages (e.g. PlInK); customisation; infrastructure deployment and ongoing maintenance; server
facilities for processing the high volume of experimental data generated by
genetic sequencing and GWAS (e.g. Illumina Genome Analyser); storage
capacity in the order of 20Tb for storage of high volumes of raw data;
visualisation.
Key words
HIGH PERFoRmAnCE ComPUTInG,
DATA mAnAGEmEnT, omICS, QUAlITy
ASSURAnCE TESTInG, GEnETIC AnAlySIS
PACKAGES, vISUAlISATIon
The Centre currently provides compute, storage/data management,
visualisation, and software development services for over twenty research
projects.
Biobank Information management System (BImS)
> 3,000 compute cores for advanced computation and data processing
Data storage and data management.
ACCESS PolICy
externally.
Address
TRINITY CENTRE FOR HIGH PERFORMANCE
COMPUTING
TCD College Green
DUBlIn 2
IRElAnD
Contact detail
Geoff BRADlEy
Tel +353 1 896 3429
geoff.bradley@tchpc.tcd.ie
www.tchpc.tcd.ie
62
COMPUTATIONAL
MATERIALS DESIGN
TYNDALL
(UNIVERSITY COLLEGE CORK)
location
CoRK, IRElAnD
Key words
ComPUTATIonAl mATERIAlS DESIGn,
nAnoPARTIClES, DRUG DElIvERy, mEDICAl
DEvICE PRoToTyPES
Computer-aided drug design and protein re-engineering for
therapeutics
Design of functionalised nanoparticles for diagnostics and drug
delivery
Design of nano-structured materials for medical devices and lab-on-achip applications
Design of electronics/materials interfaces for the development of
medical device prototypes
Several in-house computer clusters provided by SFI/HEA
The national ICHEC supercomputing facilities
European computing facilities through PRACE/DEISA initiatives
IBm’s deep computing facilities in new york, USA
Commercial and free software including CHARmm, nAmD, vASP,
Turbomole and Gaussian and for visualisation/analysis, materials
Studio, vmD and mathematica
ACCESS PolICy
externally.
Address
TYNDALL NATIONAL INSTITUTE
University College, Cork
CoRK
IRElAnD
Contact detail
Damien THomPSon
Tel +353 21 490 4327
damien.thompson@tyndall.ie
www.tyndall.ie
63
INSTITUTE OF
MOLECULAR
MEDICINE
As a core facility, the Trinity Genome Sequencing laboratory provides the
following assistance to researchers interested in undertaking a project
using the Illumina Genome Analyzer:
Advice on study design and costs
location
DUBlIn, IRElAnD
Key words
GEnomE SEQUEnCInG, molECUlAR
mEDICInE, DnA SEQUEnCInG, TRAnSCRIPTomE AnAlySIS, GEnE REGUlATIon AnD
ConTRol
Advice and guidance on sample preparation
library preparation, cluster generation, sequencing and primary data
analysis
Advice and guidance on secondary data analysis
Illumina Genome Analyzer II (GAII)
The range of genetics applications available includes
(i) DnA Sequencing,
(ii) Transcriptome Analysis
(iii) Studies of Gene Regulation and Control. This core facility is
supported by full-time research staff and is available to all academic
and industry-based researchers in Ireland.
ACCESS PolICy
Internal access, access through external collaborations, service provision
externally.
Address
TRINITY GENOME SEQUENCING
LABORATORY
College Green
DUBlIn 2
IRElAnD
Contact detail
Derek moRRIS
Tel. +353 1 8962424
morrisdw@tcd.ie
www.medicine.tcd.ie
64
MICROARRAY
PROFILING
NICB
(DCU)
location
DUBlIn, IRElAnD
Key words
ARRAy PRoFIlInG, RnA, CAnCER, HIv,
ISolATIon oF RnA FRom CUlTURE,
TISSUES,
Experimental design (use of triplicate biological replicate samples,
etc.)
Isolation of RnA from culture, tissues, etc. (typically Qiagen Rneasy
RnA isolation kit)
Assessment of RnA quality (RnA/cRnA QC assayed using the
Agilent RnA 6000 nAno KIT 1/Agilent Bioanalyser and the Thermo
Scientific nanoDrop 1000 Spectrophotometer)
RnA processing to labelled cRnA/ssDnA probes as per
manufacturer’s instructions, with sample tracking
Sample hybridization, fluidics protocols and chip scanning of
appropriate Affymetrix GeneChips® (e.g. Human Gene 1.0 ST arrays)
according to manufacturer’s instructions
Expression Console®-generated QC metrics monitored for individual
chips and for batch variation in accordance with good experimental
practice
Affymetrix Genechip system
Applied Biosystems 7500 and 7900HT Real Time PCR platforms
ACCESS PolICy
externally
Address
NICB
Ballymun
DUBlIn 11
IRElAnD
Contact detail
Padraig DoolAn
Tel. +353 1 7005624
padraig.doolan@dcu.ie
www.nicb.dcu.ie
65
ILLUMINA
SEQUENCING
GENOME
SEQUENCING
PLATFORM
CONWAY INSTITUTE
(UCD)
location
DUBlIn, IRElAnD
The Illumina Sequencing Platform or next generation sequencing platform
is used for a variety of genomics/transcriptomics and epigenomics
studies. The platform was established in Jan 2008 and provides for the
generation of massive quantities of sequence data to answer a variety of
biologically relevant questions.
Users include genomic research centers, pharmaceutical companies,
academic institutions, clinical research organizations and biotechnology
companies. Its tools provide researchers with the capability to perform
genetic tests needed to extract medical information from advances in
genomics and proteomics.
Key words
IllUmInA SEQUEnCInG PlATFoRm,
TRAnSCRIPTomICS, EPIGEnomICS
Illumina Genome Analyzer II (GAII)
Illumina Genome Analyzer II (GAIIx) (modified machine which allows
for an extra 20% of data to be generated from each flowcell and the
ability to do paired end sequencing).
This Facility supports the research programmes of a number of PIs within
UCD and at collaborating institutions, including TCD, Ul, RCSI, Teagasc,
mRC Edinburgh along with industry collaboration such as Pfizer.
ACCESS PolICy
externally.
Address
Belfield, Dublin 4
IRElAnD
Contact detail
Brendan loFTUS
Tel. +353 1 7166718
brendan.loftus@ucd.ie
www.ucd.ie
66
GENOTYPING
LABORATORY
location
DUBlIn, IRElAnD
Key words
GEnoTyPInG, HyBRIDIZATIon,
EXPRESSIon, AUTISm, GolDEnGATE
GEnoTyPInG
The Genotyping laboratory was established in 2008 and has an Illumina
BeadStation 500GX which is a system for genetic analysis applications
including GoldenGate Genotyping and Direct Hybridization Gene Expression
applications.
Advice on experiment design
laboratory protocols explained and carried out
Analysis of results
GoldenGate Genotyping and Infinium Automation (Post-Amp)
Infinium option Standard Throughput Package (Single and multiSample)
Autoloader - Single Scanner
Extended Warranties
Data Storage facilities
Tecan Robot
microarray 1m- duo beadchips
ACCESS PolICy
externally.
Address
Belfield
DUBlIn 4
IRElAnD
Contact detail
Sean EnnIS
Tel +353 1 7166685
Sean.ennis@ucd.ie
www.ucd.ie
67
AFFYMETRIX
GENECHIP
TECHNOLOGY
UCD
location
DUBlIn, IRElAnD
Key words
AFFymETRIX GEnECHIP,
mICRoARRAyS, DnA, CRnA,
ImmUnoPRECIPITATIon
Initial meeting to discuss experimental design and strategy
Advice on sample preparation and provision of protocols
optional sample preparation and labelling service
Quality assessment of total RnA and cRnA using the Agilent
Bioanalyser
Array hybridisation, washing, staining and scanning
Assessment and monitoring of array quality
Primary data analysis with AGCC Software and provision of QC report
and all data files
GeneChip 3000 7G scanner
Automated Fluidics 450 station
Hybridisation oven
GeneChip workstation with AGCC Software
Agilent Bioanalyser
ACCESS PolICy
externally.
Address
Belfield
DUBlIn 4
IRElAnD
Contact detail
Alison mURPHy
Tel +353 1 716 6955
alison.murphy@ucd.ie
www.ucc.ie
68
IMM-FCF
INSTITUTE OF MOLECULAR MEDICINE
(TCD)
location
DUBlIn, IRElAnD
Key words
molECUlAR mEDICInE, FloW
CyTomETRy, FISH, RnA, PCR, CAnCER,
nAnoTECHnoloGy
Imm-FCF is an open-access multi-user facility which was established in
2008. Flow cytometry plays an integral role in the understanding of many
biological processes, due to its ability to simultaneously analyze multiple
parameters on individual cells.
This technology enables specific subpopulations of cells to be
characterized and, if required, isolated for further investigation e.g. for
colony assays, cell lines, RnA analysis, FISH, microarrays, PCR and cell
micromanipulation. The facility enables studies e.g. into stem cell research,
immunology, vaccine research, cancer research and nanotechnology.
2 x Beckman Coulter 9-colour Cyans
Becton Dickinson FacsCalibur
Beckman Coulter moFlo Cell sorter
Green laser for mCherry and enhanced PE labels
Automacs for rapid enrichment of cell populations
ACCESS PolICy
externally.
Address
College Green
DUBlIn 2
IRElAnD
Contact detail
Ann ATZBERGER
Tel +353 1 8963055
atzberga@tcd.ie or facs@tcd.ie
www.tcd.ie
69
FLOW CYTOMETRY
CORE
CONWAY INSTITUTE
(UCD)
location
DUBlIn, IRElAnD
Key words
FloW CyTomETRy, CAnCER, STEm CEllS,
APoPToSIS, vIABIlITy, CEll CyClE,
The UCD Flow Cytometry Core was established in 2004.
Flow Cytometers are systems for the qualitative and quantitative
measurement of biological and physical properties of cells and other
particles. These properties are measured when these events pass
through a laser beam in a single-file.
2 days training course
Instrumentation technical expertise and software for flow cytometric
analyses. Trained users prepare their own samples in advance and
run them on one of the flow cytometers.
Coulter Xl-mCl
Coulter FC500
Cyan ADP (Blue, red and violet laser)
Cyan ADP (Blue, red and Uv laser)
Accuri C6
BD FACSAria cell sorter
The UCD Flow Cytometry Core has provided service to more than 150
users for 54 research groups within UCD Schools, non UCD institutions,
hospitals and private companies.
The facility supports research projects in the areas of cancer, stem cells,
apoptosis, viability, cell cycle, calcium flux, transfection, bionanoparticles
and immunology.
ACCESS PolICy
externally.
Address
Belfield
DUBlIn 4
IRElAnD
Contact detail
Alfonso BlAnCo
Tel. +353 1 7166836/6947
alfonso.blanco@ucd.ie
www.ucd.ie
70
CELL
CHARACTERISATION
FACILITY
NICB
(DCU)
location
DUBlIn, IRElAnD
Key words
Tissue Processing and Sectioning
Automated Slide Staining
Wide-field microscopy
Confocal microscopy
laser Capture micro-Dissection
Flow Cytometry (Analysis & Sorting)
metamorph Image Analysis software
CEll CHARACTERISATIon, TISSUE
PRoCESSInG, SlIDE STAInInG
The Cell Characterisation Facility at the nICB is equipped with a wide range
of specialised equipment to study the internal processes within cells and
their interactions with each other, including a time-lapse nikon Eclipse Tie
fluorescent inverted microscope.
The Facility is equipped with a leica SP2 AoBS Confocal microscope,
which is capable of spectral scanning and un-mixing and is suitable for
FRAP, FlIP and FRET. Specific cell populations can be micro dissected
from tissue sections and cell cultures by using the PAlm lCmD. The Facility also has flow cytometry capability.
ACCESS PolICy
externally.
Address
DUBLIN CITY UNIVERSITY
Ballymun Avenue
DUBlIn 11
IRElAnD
Contact detail
Finbarr o SUllIvAn
Tel. +353 1 7005726
finbarr.osullivan@dcu.ie
www.nicb.dcu.ie
71
MDG
NATIONAL COMPUTATIONAL
DRUG DESIGN
(TCD)
location
DUBlIn, IRElAnD
Key words
DRUG DESIGn, EnDoCRInE, onColoGy,
lIGAnD-BASED
The molecular Design Group (mDG) utilise Structure-Based and
ligand-Based Drug Design computational technologies together with
virtual screening approaches to rationally tailor small molecules for
the modulation of therapeutically relevant biological macromolecules
- enzymes and receptors. All design are validated through chemical
purchase/synthesis and biological assay.
The mDG has a significant focus on endocrine and oncology targets,
working on the nuclear hormone receptor super-family and apoptosis
related targets but this approach can be applied to a multitude of protein
targets.
Two computer clusters/multiple PCs/SGI workstations
Software/provider
moE
Pipeline Pilot
openEye
Accelrys
ChemAxon
molecular networks
ACCESS PolICy
externally.
Address
College Green
DUBlIn 2
IRElAnD
Contact detail
Darren FAynE
Tel +353 1 8962904
fayned@tcd.ie
www.tcd.ie
72
MASCI
MATHEMATICS APPLICATIONS
CONSORTIUM
FOR SCIENCE & INDUSTRY
(UNIVERSITY OF LIMERICK)
location
lImERICK, IRElAnD
Key words
mATHEmATICS, mUlTIPHySICS,
oSmolAlITy, CoPolymERS, ComPUTER
AlGEBRA SySTEmS
mASCI’s expertise lies in the area of developing mathematical models.
To do this we formulate problems as mathematical questions, derive a
model from fundamental equations, reduce the model by analysis of the
relative importance of each of the terms and then solve the reduced
model.
This approach emphasis is insight over complexity and is complementary
to other modelling approaches based on statistical analysis and intensive
numerical simulations.
mACSI researchers use a number of computational tools including: the
multiphysics finite element package ComSol; numerical problem solving
environments (mATlAB, R, octave); computer algebra systems, (maple,
maxima); high and low level programming languages (python, C++, C,
FoRTRAn).
mACSI supports a broad range of the mathematical modelling projects.
ACCESS PolICy
externally.
Address
M.A.S.C.I.
University of limerick
Co. lImERICK
IRElAnD
Contact detail
martina o’SUllIvAn
Tel. +353 612 02293
martina.osullivan@ul.ie
www.macsi.ul.ie
73
ZEBRAFISH FACILITY
(UCD)
location
DUBlIn, IRElAnD
Key words
ZEBRAFISH, TRAnSGEnIC, DRUG
DISCovERy, In-SITU HyBRIDIZATIon,
EmBRyo mICRoInJECTIon, FlUoRESCEnT
mICRoSCoPy
The Zebrafish Facility is the largest in Ireland with a current capacity of
~25,000 fish, enabling the performance of genetic and pharmacological
screens. This Facility is equipped with the infrastructure to perform
microinjections and microscopy. Techniques such as PCR amplification,
cloning, DnA sequencing, in-situ hybridization, Immunohistochemistry,
embryo microinjection (transgenics) and fluorescent microscopy are fully
operational within the Facility.
Confocal microscopy & Digital Imaging
Electroporation in/ex vivo
Electroretinography equipment
Embryo microinjections equipment
Fluorescent microscopy
Flow Cytometry
Histology & Digital Imaging
ACCESS PolICy
The Zebrafish Facility enjoys access to an extensive range of facilities and
equipment, and has access through external collaborations.
Address
ZEBRAFISH FACILITY
UCD
Belfield
DUBlIn 4
IRElAnD
Contact detail
Breandan KEnnEDy
Tel. +353 1 716 6740
www.ucd.ie/sbbs
brendan.kennedy@ucd.ie
74
CENTRE FOR LIVE
CELL IMAGING
CONWAY INSTITUTE
(UCD)
location
DUBlIn, IRElAnD
Key words
The goal of the imaging core facility is to provide state-of-the-art
microscopy and in vivo imaging technologies to researchers within the
Conway Institute, UCD and the wider Irish scientific community.
Through the expertise of its personnel, the Centre strives to maximize
direct engagement with researchers in order to enhance imaging-based
experimentation strategies, optimize future imaging investments, and
facilitate collaborative links between academic staff, industry and other
core technologies.
lIvE CEll ImAGInG, mICRoSCoPy,
mUlTI-DImEnSIonAl, FlUoRESCEnT,
TRAnSmISSIon
The inverted fully motorized nikon Eclipse Ti-E microscope is equipped
with 5 lasers for 445nm, 488nm, 515nm, 560nm and 595nm excitation
for the life cell imaging can be used in laser Confocal, TIRF or FRAP PA
mode and most sensitive Andor camera; a spinning disc, a motorized
Piezo Z250 stage for multi-dimensional imaging both in fluorescent and
transmission light.
The microscope is operated by the Andor IQ software.
olympus IX81 microscope ; Zeiss Axiovert 200 m epi-fluorescent
microscope ; Zeiss Axiovert 200 m / Zeiss Axioobserver microscopes
ACCESS PolICy
externally.
Address
Belfield
DUBlIn 4
IRElAnD
Contact detail
Dimitri SCHolZ
Tel +353-1 716 6736
dimitri.scholz@ucd.ie
www.moleculardevices.com
75
TCIN
TWO-PHOTON & CONVENTIONAL
CONFOCAL
IMAGING LABORATORY
(TCD)
The Two-photon and Conventional Confocal Imaging laboratory supports
projects in a broad range of research areas including neurogenesis, preand post-synaptic labelling and live cell imaging.
location
DUBlIn, IRElAnD
Key words
TWo-PHoTon, ConFoCAl, SynAPTIC
lABEllInG, nEURoGEnESIS
Zeiss 510 meta nlo system on an upright microscope with standard and
coherent chameleon lasers and accessories for Fluorescence lifetime
Imaging (Becker-Hickl)
ACCESS PolICy
externally.
Address
College Green
DUBlIn 2
IRElAnD
Contact detail
mani RAmASWAmI
Tel +353 1 8968400
mani.ramaswami@tcd.ie
www.tcd.ie
76
NBIP
BIOPHOTONICS & IMAGING
PLATFORM
(RSCI)
location
DUBlIn, IRElAnD
Key words
BIoPHoTonICS, BIoSTRUCTURE, HUmAn
RESEARCH ImAGInG, PHySICAl AnD lIFE
SCIEnCES
Bridge the Physical and life Sciences interface and through
partnership with Industry, to enhance technology developments in
Biophotonics and Imaging
Provide a national access to Core Facilities in molecular, Cellular,
Small Animal and Human Research Imaging
Provide the infrastructure for Ireland’s participation in large-scale
international research programmes underpinned by Biophotonics and
Imaging
A complete list of nBIP Ireland equipment and booking instructions is
available via the nBIP Ireland moodle site: www.nbipireland.ie/moodle.
ACCESS PolICy
All researchers interested in using an equipment item should contact the nBIP
Ireland Facility Director/Research Engineer/Technician responsible for the
equipment item to apply for access and/or schedule training. The appropriate
contact person is listed under each equipment item on the nBIP Ireland moodle
site. The platform is deeply committed to providing access to nBIP Ireland
equipment to all platform members, especially where access is intended to lead
to collaborations and joint outputs such as co-authored publications, joint IP filings
and grant applications. Access on a «service» basis is subject to availability of
instrument time and support staff.
Address
NBIP IRELAND
Research office
121 St Stephens Green
DUBlIn 2
IRElAnD
Contact detail
Eadaoin mC KIERnAn
Tel. +353 1 4022374
eadaoinmckiernan@rcsi.ie
www.nbipireland.ie
77
NANOSCALE
FUNCTION GROUP
CONWAY INSTITUTE
(UCD)
location
DUBlIn, IRElAnD
Key words
nAnoSCAlE FUnCTIon, ATomIC FoRCE
mICRoSCoPy, DATA AnAlySIS
The nanoscale Function Group is a research group specialising in the
development of high performance Atomic Force microscopy (AFm)
techniques and the application of these techniques to biological and
biomedical systems for imaging applications as well as mechanical
characterisation on the nano and micro scale.
The group provides access to two of its state of the art AFm’s which are
combined with advanced optical microscopes. The group also offers expert
advice and training on instrument use and data analysis.
JPK nanowizard AFm combined with nikon Ti/E epi-fluorescence
microscope. Equiped with temperature controlled fluid cell. optical
microscope includes phase contrast and epi-fluorescence imaging.
Asylum mFP3D AFm combined with nikon Ti/E A1R confocal+TIRF
microscope. Equipped with temperature controlled fluid cell. Confocal
microscope has laser lines from 405 - 637 nm, resonant scanner,
vAAS detector and Andor Ixon+ EmCCD camera for sensitive TIRF
imaging.
ACCESS PolICy
externally.
Address
CONWAY INSTITUTE
University College Dublin Belfield
DUBlIn 4
IRElAnD
Contact detail
maarten vAn ES
Tel. +353 1 7166762
maarten.vanes@ucd.ie
www.nanofunction.org
78
MSSI
MATERIALS & SURFACE SCIENCE
INSTITUTE
(UNIVERSITY OF LIMERICK)
location
lImERICK, IRElAnD
SURFACE SCIEnCE
Key words
HIGH RESolUTIon, ElECTRon mICRoSCoPy
mSSI employs a team of PhD-trained research staff to support
researchers using these facilities who combine research expertise in
chemistry, physics, engineering, materials science and nanotechnology
with the technical skills required to perform cutting edge research.
Training on all instrumentation in the facility
Pore size surface area analysis
mechanical testing facilities (scratch testing, tensile testing)
molecular imaging and modeling
Particle size analyser & zeta potential
mechanical testing facilities (scratch testing, high-speed tensile
testing, digital image correlation)
Extensive sample preparation facilities
Sessile drop contact angle analysé with controlled environment
sample chamber
High-resolution electron microscopy
Jeol 2100F & 2010 TEm with STEm, EDX, HAADF, SEI/BSE
detector, tomography
Hitachi SU70 field emission SEm with BSE detector, EDS, WDX &
EBSD
Jeol JSm 5600 & Jeol Carryscope SEm for high-throughput sample
screening
FIB200 Focussed Ion Beam/Secondary Ion mass Spectrometry
workstation
ACCESS PolICy
externally.
Address
MSSI BUILDING
University of limerick
Castletroy
lImERICK
IRElAnD
Contact detail
Gordon ARmSTRonG
Tel. +353 61 213127
Tel. +353 61 234765
mssi@ul.ie and inspire@ul.ie
www.ul.ie/mssi
79
HIGH CONTENT
SCREENING FACILITY
(TCD)
location
DUBlIn, IRElAnD
Key words
HIGH ConTEnT SCREEnInG, SAmPlE
PREPARATIon, FlUoRESCEnT lABElInG
This facility is capable of genome wide scale screening or library screening
as well as small scale assays.
The HCS has a core competence in assay development, imaging and
image analysis
Assay development
High resolution and high throughput cellular and tissue imaging.
Cellular and tissue image analysis
High throughput screening
Target identification
Target validation
Toxicity and efficacy studies.
2 GE Incell 1000 high Content imaging systems
Cellomics (Thermo) High Content Imaging System
Deerac high Throughput nano-dispenser
matrix Well mate reagent and cell dispenser
matrix hydra with 96 well head and 4 position stage
Kinedix SCARA plate handling robot with 90 plate stacking system
Affymetrix array scanner for low density custom micro arrays and
tissue micro-arrays
Zeiss meta 510 Con-focal microscope
Perkin Elmer Ultra-view Spinning Disc con-focal microscope
ACCESS PolICy
externally.
Address
College Green
DUBlIn 2
IRElAnD
Contact detail
Anthony mITCHEll DAvIES
Tel +353 86 322 7692
amitche@mail.tcd.ie
www.tcd.ie
80
MICROSCOPY
CENTRE
CRANN
(TCD)
location
DUBlIn, IRElAnD
Key words
mICRoSCoPy, nAnoFABRICATIon,
ElECTRon BEAm lITHoGRAPHy
The centres offers custom designed ultra-high specification microscope
operating environments, dedicated wet and dry sample preparation
labs and a high specification electron beam lithography capability with a
dedicated clean-room and resist processing facilities on-site.
The centre serves the internal CRAnn client community and Principal
Investigator base, the wider academic community at home and in
a European context, and a growing roster of industrial clients and
collaborators.
A mandate of the centre is to facilitate and underpin research excellence
that is cross-disciplinary in nature.
Imaging by Helium Ion microscope
Analytics by Helium Ion microscope
HRSEm imaging
SEm material analytics
microscopy sample prep and sample coating
FIB TEm sample prep
FIB nanofabrication
FEI Strata 235 Focused Ion Beam
Zeiss Ultra Plus Scanning Electron microscope
Zeiss Supra 40Electron Beam lithography SEm
Zeiss Evo 50Electron Beam lithography SEm
ACCESS PolICy
externally.
Address
UNIT 27-29
Trinity Enterprise Centre
Grand Canal Quay
DUBlIn 2
IRElAnD
Contact detail
Hong Zhou ZHAnG
Tel +353 1 896 4655
hongzhou.zhang@tcd.ie
www.trinityenterprisenetwork.ie
81
CONFOCAL LASER
SCANNING
MICROSCOPY
CONWAY INSTITUTE
(UCD)
location
DUBlIn, IRElAnD
Key words
ConFoCAl lASER, EmISSIon
FInGERPRInTInG, Ion ImAGInG
The lSm 510mETA detector facilitates ‘Emission Fingerprinting’, a
technique for the detection, spectral separation and visualization of
multiple fluorescent labels including fluorophores with overlapping
emission spectra such as CFP, GFP and yFP which cannot be separated
using conventional methods.
The system can also be used for other techniques such as FRET, FRAP etc
and Ion Imaging
Provision of a two day introductory training course on the use and
application of the Zeiss confocal lSm 510 UvmETA system.
Provision of one-to-one assisted sessions for infrequent instrument
users or researchers who require images for publication.
Provision of training on off-lineimage analysis software.
Through the Director of Biological Imaging, advice on experimental
design, application, appropriate equipment usage and training
The system is the Carl Zeiss lSm 510 UvmETA confocal laser scanning
microscope mounted on an;
Axiovert 200m inverted computer controlled microscope.
Condensor for conventional transmitted light brightfield, and DIC
objectives: Plan neofluor x10/0.3nA, x20/0.5nA, x40/1.3nA oil
DIC, Plan Apochromat x63/1.4nA oil DIC
Conventional fluorescence illuminator with HBo 100 light source
Transmitted light illuminator with HAl 100 light source
Argon ion laser emitting 458/477/488/514nm lines
ACCESS PolICy
externally.
Address
CONWAY INSTITUTE OF BIOMOLECULAR
& BIOMEDICAL RESEARCH
DUBlIn
IRElAnD
Contact detail
Anne CUllEn
Tel +353 1 716 6741
anne.cullen@ucd.ie
www.ucd.ie
82
APERIO DIGITAL
SLIDE SCANNING
CONWAY INSTITUTE
(UCD)
location
DUBlIn, IRElAnD
Key words
CAnCER, CARDIovASCUlAR, DIABETES,
REnAl DISEASES, ImmUno/HISToCHEmICAl, DRUG DISCovERy, CAnCER RESEARCH,
TElEPATHoloGy
The Aperio Digital Slide Scanning Facility was established in 2004 and
comprises a microscope slide scanner, which digitises entire slides at high
quality resolution, whether they are full-face sections, cell pellet arrays or
tissue microarrays.
The system comes with a host of software applications that enable you to
scan, compress, view and analyse your digital slides. This powerful system
allows you to experience fast, high-capacity digital scanning.
The digital slides can be managed through a comprehensive, webbased digital pathology information management software suite. This
was developed for digital slide viewing and conferencing, data archival,
intelligent retrieval and image analysis. Its high-throughput of superior
images renders its application fundamental in drug discovery, cancer
research and telepathology to name just a few.
Aperio ScanScope XT system with 120-slide capacity controlled
by ScanScope Console software with 20x and 40x magnification
choices
ImageScope software, allows viewing and sharing of slides. Provides
features such as: instant zoom and pan of images, annotation and
analysis of digital sides
Spectrum, a web-based software that facilitates the management of
digital slides
Access to various algorithms for image analysis for
immunohistochemical staining etc., in conjunction with ImageScope
through Spectrum
Data storage is via a server system, which in addition hosts
Spectrum software
ACCESS PolICy
externally.
Address
UCD CONWAY INSTITUTE OF
BIOMOLECULAR
& BIOMEDICAL RESEARCH
University College Dublin, Belfield
DUBlIn 4
IRElAnD
Contact detail
Janet mCCoRmACK
Tel +353 1 716 6956
janet.mccormack@ucd.ie
www.ucd.ie
83
AMRF
ADVANCED MICROSCOPY RESEARCH
FACILITY
(UCC)
location
CoRK, IRElAnD
Key words
TRAnSmISSIon ElECTRon mICRoSCoPy,
nAnoPARTIClES, TWo PHoTon
mICRoSCoPy, Em FACIlITy
The Em Facility has the capacity to undertake a limited amount of work, as
well as offering assistance or advice in the following areas:
Transmission Electron microscopy
Scanning Electron microscopy
TEm sample preparation
SEm sample preparation
Services provided by the Em Facility staff can be tailored to the needs of
the investigator. The examination of a broad range of specimens from
cultured cells to polymers, and from nanoparticles to botanical samples
can be carried out in the Em Facility.
The Em Facility houses a Scanning Electron microscope (JEol 5510) and
a Transmission Electron microscope (JEol 2000FXII). The Jeol 5510
SEm is equipped with an Energy Dispersive X-ray microanalysis Detector
(oxford Instruments). Both microscopes are capable of digital imaging.
ACCESS PolICy
externally.
Address
ADVANCED MICROSCOPY RESEARCH
FACILITY (AMRF)
Room G.08, BioSciences Institute
UnIvERSITy CollEGE CoRK
CoRK
IRElAnD
Contact detail
myriam CoTTER
Tel +353 21 4901391
m.cotter@ucc.ie
www.ucc.ie
84
BIONANO
LABORATORY
CRANN
(TCD)
location
DUBlIn, IRElAnD
Key words
BIonAno, nAnoSTRUCTURES, BIoHAZARD
FACIlITy
The Bionano laboratory was established in 2008 at the Centre for
Research on Adaptive nanostructures and nanodevices (CRAnn) at TCD
and is dedicated to research at the interface between the physical and life
sciences.
It is a type 2 Biohazard Facility with cell culturing capability.
Advance microscopy
Cellular preparation
Customised solution for single-cell experimental work
Single molecule manipulation
Differential cantilever array diagnostic
Ink-jet spotting
Rapid prototyping
Upright fluorescent olympus BX51m microscope equipped with a
Xm10 camera
Inverted fluorescent olympus CKX41 microscope equipped with a
Q-imaging micropublisher camera
Class II cell culture flow hoods
Ultrasound standing wave systems - manipulation of cells in
suspension using various ultrasound wave fields for the formation of
2 and 3-D cell aggregates
Static magnetic fields of various strengths for cell manipulation
narishige micromanipulator - 3D micromanipulator for single cell
handling
ACCESS PolICy
externally.
Address
CENTRE FOR RESEARCH ON ADAPTIVE
NANOSTRUCTURES AND NANODEVICES,
DUBlIn 2
IRElAnD
Contact detail
martin HEGnER
Tel +353 1 8962285 and 1 8964632
martin.hegner@tcd.ie
www.crann.tcd.ie
85
BIOINFORMATICS
CORE FACILITY
NICB
(DCU)
location
DUBlIn, IRElAnD
Key words
BIoInFoRmATICS, DCHIP/GEnESPRInG
AnAlySIS, GEnE onToloGy,
The Bioinformatics Core Facility at the nICB undertakes bioinformatics
analysis using the dChip/genespring analysis of datasets, together with
Gene ontology (Go) and literature/pathway mining analysis (i.e. Pathway
Studio).
Additional research includes the development of novel data analysis
routines using R and Bioconductor and the application of multivariate
statistics and machine learning approaches (incl. Principal components
analysis, Partial least squares, artificial neural networks and Support
vector machines).
Research is also carried out on robust methods of gene selection using
techniques such as recursive feature elimination and jack-knife variance
estimation. The Bioinformatics Core Facility also has access to the Stokes
HPC at the Irish Centre for High End Computing (ICHEC).
dChip/genespring analysis of datasets
Gene ontology (Go) and literature/pathway mining analysis, i.e.
Pathway Studio
ACCESS PolICy
externally.
Address
DUBLIN CITY UNIVERSITY
Glasnevin,
DUBlIn 9
IRElAnD
Contact detail
Padraig DoolAn
Tel +353 17005624
padraig.doolan@dcu.ie
www.nicb.dcu.ie
86
CRANN
CENTRE FOR RESEARCH ON
ADAPTIVE NANOSTRUCTURES AND
NANODEVICES
location
DUBlIn, IRElAnD
Key words
PHySICS, CHEmISTRy, mEDICInE,
EnGInEERInG AnD PHARmAColoGy,
nAnoSTRUCTURES AnD nAnoDEvICES
CRAnn was established in 2003 by Principal Investigators (PIs) from
the Schools of Physics and Chemistry at Trinity College Dublin (TCD) in
partnership with University College Cork (UCC).
Since then, CRAnn has developed from that small cluster of PIs into a
national leading and internationally competitive research institute with
17 PIs based across multiple disciplines including Physics, Chemistry,
medicine, Engineering and Pharmacology, and a total of 250 researchers.
CRAnn was funded predominately by Science Foundation Ireland (SFI), in
partnership with the universities and industry, and was formed to harness
the cross disciplinary nanoscience research of individual PIs to deliver
world leading research outputs and to enable CRAnn researchers to
address key industry challenges.
The 22,000 square foot CRAnn Central Equipment Facility [CEF], is an
integrated infrastructure, equipment, and human capital platform offering
a core of key facilities and techniques to the CRAnn client base.
Facilities such as cleanroom, microscopy centre, nano bio facility, femtosecond laser laboratory, and scanning probe microscopes are managed
by technical specialists and accessed by researchers from a wide variety
of research backgrounds.
ACCESS PolICy
CRAnn has technologies available in the following key areas for commercial
exploitation; medical Devices / Pharmaceutical Bio Sensing Semiconductors
optics Energy. CRAnn wishes to engage with all enterprises from Start-ups
to multinational businesses. We operate a comprehensive engagement model,
scalable to each organization’s requirements.
Address
College Green
DUBlIn 2
IRElAnD
Contact detail
Diarmuid o’BRIEn
diarmuid.obrien@tcd.ie
Tel +353 (0) 896-3089
Tel +353 (0) 896-3030
www.crann.tcd.ie
87
NICB
NATIONAL INSTITUTE FOR CELLULAR
BIOTECHNOLOGY
(DCU)
location
DUBlIn, IRElAnD
Key words
CEllUlAR BIoTECHnoloGy, BIoloGICAl
CHEmISTRy, oCUlAR DISEASES, CHEmISTS
AnD ComPUTER SCIEnTISTS, InTERDISCIPlInARy SCIEnCE, CAnCER, mICRoBIAl
DISEASES, DIABETES
The nICB is a multidisciplinary centre of research in fundamental and
applied Cellular Biotechnology, molecular Cell Biology, ocular diseases and
Biological Chemistry.
It includes a multidisciplinary team of Cell and molecular Biologists,
Biotechnologists. Chemists and Computer scientists. The institute draws
from the established expertise of researchers in Dublin City University,
IT Tallaght and nUI maynooth with the aim to be a Centre of world-class
expertise, in Cellular and molecular Biotechnology, a diverse and expanding
interdisciplinary science.
The nICB has combined the variety of expertise of its researchers
to develop targeted research programmes in key areas relating to
identification of new therapeutic targets and diagnostic methods for
disease (in particular for cancer, microbial diseases and diabetes) and
understanding of basic biological processes including regulation of gene
expression during cell differentiation and their translational to industrial
and medical applications.
Proteomics, microarrays and Bioinformatics & Biostatistics
Advanced microscopy, Culture Collection, Cancer Drug Quantitation
monoclonal Antibodies to Study Cancer, Cell & molecular Biology
Underlying Cellular Systems for Biopharmaceutical Production
ACCESS PolICy
DCU is committed to providing open access to its research infrastructure to
support research excellence and strategic collaborations underpinning national
policy objectives.
Address
NATIONAL INSTITUTE FOR CELLULAR
BIOTECHNOLOGY
Glasnevin
DUBlIn 9
IRElAnD
Contact detail
martin ClynES
Tel. +353 1 7005720
martin.clynes@dcu.ie
www.nicb.dcu.ie
88
INSTITUTE OF
BIOMOLECULAR
& BIOMEDICAL
RESEARCH
CONWAY INSTITUTE
(UCD)
location
DUBlIn, IRElAnD
Key words
BIomolECUlAR AnD BIomEDICAl
RESEARCH
UCD Conway Institute of Biomolecular and Biomedical Research is a
multidisciplinary centre for research funded by an initiative of the Irish
Higher Education Authority; the Programme for Research in Third level
Institutions (PRTlI).
located on the 300-acre Belfield campus of University College Dublin
(UCD), the largest university in Ireland, UCD Conway Institute brings
together over 550 research staff from all over the University and its
associated teaching hospitals.
UCD Conway Institute is a community of biomedical researchers
exploring cell and systems biology for creative solutions in human
disease.
UCD Conway Institute will be a global leader in biomedical research
and through partnership will translate this knowledge to benefit
patients. Through interdisciplinary programmes, the close
collaboration of scientists with clinicians and industry partners
underpins the translational nature of this research.
The research activity of the Institute can also be described in terms of
the biological problem or type of disease being studied. There are four
major areas of focus; cancer biology, vascular biology, neuroscience and
infection, immunity and inflammation.
Strong links with a number of major academic teaching hospitals have
been developed to underpin this activity. Scientists and clinicians working
in UCD Conway Institute and affiliated hospitals are making important
contributions to our understanding of the causes and consequences of
diabetes, arthritis, Alzheimer’s disease, cardiovascular and lung disorders
as well as breast and prostate cancer.
Address
UCD CONWAY INSTITUTE OF
BIOMOLECULAR
AND BIOMEDICAL RESEARCH
Belfield
DUBlIn 4
IRElAnD
The lower ground of the hub provides a lecture / conference theatre for
128 people and specialist research laboratories including a transgenic
facility and a number of core technologies such as high-field nuclear
magnetic resonance and protein crystallography.
ACCESS PolICy
externally.
Contact detail
Walter KolCH
Tel. +353 1 7166700
walter.kolch@ucd.ie
www.ucd.ie
89
NIBRT
NATIONAL INSTITUTE FOR
BIOPROCESSING
RESEARCH & TRAINING
(UCD)
location
DUBlIn, IRElAnD
Key words
BIoPRoCESSInG RESEARCH, PRoTEIn
EnGInEERInG, GlyCAn AnAlyTICAl
TECHnIQUES, GEnE REGUlATIon,
RADIoACTIvE ASSAyS
The national Institute of Bioprocessing Research and Training (nIBRT)
is an innovative collaboration between University College Dublin, Trinity
College Dublin, Dublin City University and the Institute of Technology Sligo.
Part funded by the IDA, nIBRT establishes a national resource for Ireland’s
rapidly expanding bioprocessing industry. nIBRT have commenced
occupation of new state-of-the art facilities in Belfield Innovation Park,
located off Fosters Avenue.
With world class research in key areas of bioprocessing, the new Institute
building will provide a critical mass of multi-purpose bioprocessing facilities
while supporting training for highly skilled personnel. Facilities include a
pilot plant to support scale up operations and to enable students to get
real time experience in an industrial environment.
Protein engineering by directed evolution.
Glycan analytical techniques including nP-HPlC, mass Spectrometry,
anion exchange.
Gene regulation by real-time PCR
In vivo activity analysis of selected glycosyltransferases by radioactive
assays
ACCESS PolICy
externally.
Address
NIBRT
Fosters Avenue
mount merrion
Blackrock
Co. DUBlIn
IRElAnD
Contact detail
Killian o’DRISColl
Tel. +353 01 215 8100
killian.odriscoll@nibrt.ie
www.nibrt.ie
90
CBBR
CENTRE FOR BIOPOLYMER &
BIOMOLECULAR RESEARCH
(AIT)
location
ATHlonE , IRElAnD
Key words
CEll CUlTURE, BIoREACToRS, ToXIColoGy,
mATERIAlS, BIoPRoCESSInG, PolymER
PRoCESSInG, mICRoBIoloGy, SynTHESIS,
AnAlyTICAl CHEmISTRy, BIoAnAlySIS
The CBBR has a capacity to undertake research in areas of :
cell line development & characterisation, gene expression, in vitro
toxicology (cell & molecular), reporter systems, ecotoxicology,
microbiology screening, chemical synthesis, analytical chemistry
& bioanalysis, protein purification, hydrogel development, polymer
processing, encapsulation, drug delivery, nanomaterials
industry services offered in analytical chemistry, physical testing,
microbiology
microscopy – bright field, fluorescence, confocal, raman, AFm, SEmEDX – applied to living and non living materials with image processing
Cell culture – 2D, 3D bioreactors, micro to larger scale
Electrophoresis – all major forms including 2D and associated
scanning
Protein purification – FPlC
Analysis – many technologies, including HPlC, GC, GC-mS-ToF, GPC,
TA, DSC, multilabel plate readers, impedance spectrometry
microbiology – microbial bioreactor
Toxicology – SCGE, xCelligence, mutation analysis
ACCESS PolICy
Collaborations exist with HEIs and industry. All agreements are negotiable.
Address
CBBR, AIT, RESEARCH HUB
East Campus
ATHlonE, Co. WESTmEATH
IRElAnD
Contact detail
neill RoWAn
Tel. +353 9064 71838
nrowan@ait.ie
www.ait.ie
91
MRI
CENTRE FOR ADVANCED MEDICAL
IMAGING
(ST. JAMES’S HOSPITAL)
location
DUBlIn, IRElAnD
Key words
mAGnETIC RESonAnCE ImAGInG, onColoGy, mUlTIPlE SClERoSIS, DIFFUSIon
TEnSoR ImAGInG, FIBRETRAK, DIFFUSIon/
PERFUSIon ImAGInG
magnetic Resonance Imaging, including the design and implementation of
mRI scan protocols for a given research purpose
mR System: Philips Achieva 3T mRI System
RF Coils: 16-channel neurovascular coil, SEnSE cardiac coil, SEnSE
head coil, T/R head coil, SEnSE torso coils, SEnSE cardiac coil,
SEnSE breast Coil, SEnSE flex coils, Shoulder/knee/wrist coils.
Capabilities/software: magnetic Resonance Angiography, functional
magnetic Resonance Imaging (fmRI), Diffusion Tensor Imaging,
fibreTrak, diffusion/perfusion imaging, DWIBS, spectroscopy,
cardiac/coronary specialist packages, pulse programming software.
ACCESS PolICy
externally.
Address
CENTRE FOR ADVANCED MEDICAL
IMAGING
St. James’s Hospital
DUBlIn 8
IRElAnD
Contact detail
Gerard BoylE
+353 1 4162769
gboyle@stjames.ie
www.3tcentre.com
92
TYNDALL
NATIONAL INSTITUTE
location
CoRK, IRElAnD
Key words
mICRo/nAnoElECTRonICS, PHoTonICS,
mICRoSySTEmS, CEnTRAl FABRICATIon
FACIlITy, THEoRy, moDEllInG AnD DESIGn,
The strengths of the institute at the present time lie in the area of
photonics, electronics, materials and nanotechnologies and their
applications for life sciences, communications, power electronics and
other industries.
Research programmes range from theoretical modelling and design
to novel material, nanotechnology, device processing and fabrication,
packaging and integration; and novel systems incorporating these new
devices.
Tyndall’s mission will be delivered through the focusing of our ICT research
activities into three strongly inter-related technical areas, identified as
critical for Ireland in the future, namely:
micro/nanoelectronics;
Photonics and microsystems.
In each of these areas, there will be a drive to develop appropriate high
quality output “from atoms to systems”, with the aim of adding significant
intellectual value to potential future products.
The drive to develop systems will be soundly based-upon leading research
in materials (especially nanomaterials), electronic and photonic devices
and advanced packaging/sub-systems integration.
It will be supported by strong activities in Theory, modelling and Design,
and a high quality Central Fabrication Facility (CFF) for materials and
devices.
ACCESS PolICy
The Tyndall national Institute in Cork provides access for researchers to state-ofthe-art research facilities & equipment, funded by Science Foundation Ireland, with
consequent benefits for research quality, innovation & economic competitiveness.
This programme is open on an all-island basis to all research staff and post
graduate students of academic institutions, providing eligible researchers with
access to Tyndall Institute facilities and expertise.
Address
TYNDALL NATIONAL INSTITUTE
lee maltings
Dyke Parade
CoRK
IRElAnD
Contact detail
Roger WHATmoRE
Tel +353 (0) 21 490 4171
roger.whatmore@tyndall.ie
www.tyndall.ie
93
ALIMENTARY
PHARMABIOTIC
CENTRE
- IMAGING AND FLOW CYTOMETRY
PLATFORM
- NEXT GEN SEQUENCING AND BIOIT
PLATFORM
location
CoRK, IRElAnD
Key Words
mICRoSCoPy, FloW CyTomETRy, CEll
CUlTURE, GEnomICS, TRAnSCRIPTomICS,
mETAGEnomICS, PyRoSEQUEnCInG
The Imaging and Flow cytometry Platform provides imaging and flow
cytometry support to investigate the cellular and molecular basis of hostmicrobe interactions in the context of normal gut physiology, inflammation
and infectious disease for biotech, pharma and functional foods
applications.
Areas of Expertise/Techniques:
microscopy – in vivo imaging, light microscopy
Flow Cytometry (Analysis and sorting)
Cell culture (Reporter assays)
Biomarkers
In vivo labelling, siRnA, signalling pathways
Bacterial genome sequences provide definitive information for
investigating biological properties and understanding the role of the
microbiota in health and disease.
The next–Gen sequencing and BioIT platforms provide expertise in
sequencing genomes, annotation of genomes, genomics, transcriptomics
and metagenomics, as well as the interpretation of associated data sets
and identification of relevant biological processes.
AREAS OF EXPERTISE/TECHNIQUES
GS Titanium next-Gen sequencing Platform from Roche- de novo
sequencing & re-sequencing of whole genomes and target DnA
regions, ultra-deep sequencing, and RnA analysis
various ‘omics’ analyses & associated bioinformatics of bacterial
species
Global gene transcriptomics, microarrays
Genome sequencing
Address
(1) ALIMENTARY PHARMABIOTIC CENTRE
Biosciences Institute
University College Cork
CoRK
IRElAnD.
ACCESS PolICy
Collaborations are welcomed and services are offered by the APC to external
parties, such as food, biotech and pharma industries, on a contract or
collaborative basis.
(2) ALIMENTARY PHARMABIOTIC CENTRE
moorepark Food Research Centre
Teagasc
Fermoy
CoRK
IRElAnD
Contact detail
Sally CUDmoRE
Tel +353 021 4901320
s.cudmore@ucc.ie
www.apc.ucc.ie
94
MARINE
BIOTECHNOLOGY
CENTRE,
ENVIRONMENTAL RESEARCH
INSTITUTE, UCC
location
CoRK, IRElAnD
Key Words
mARInE GEnomICS/GEnETICS,
mETAGEnomICS, EnvIRonmEnTAl
mICRoBIAl GEnomICS, mARInE
BIoTECHnoloGy
The marine Biotechnology Centre is based in the Environmental Research
Institute (ERI) of University College Cork. The research is based both on
culture dependent and culture independent (metagenomic) strategies,
with the aim to identify microorganisms or metagenomic clones from
marine associated microbial ecosystems, which produce bioactive compounds with potential antimicrobial, antiviral, anticancer, antifungal and
anti-biofouling activities.
The marine Biotechnology Centre activity focuses primarily on the marine
sponge ecosystems, as these are known to produce many novel bioactive
compounds, including polyketides. High throughput screening platforms
are being employed together with novel prokaryotic and eukaryotic heterologous expression systems. These novel heterologous expression systems
represent a “core capability”, which can facilitate the high throughput
screening of other metagenomic libraries, generated from different types
of starting materials. novel enzymes, which are used by the Irish food and
pharmaceutical industry, such as proteases and many carbohydrate metabolising enzymes (glucanases, xylanases, amylases, chitinases), together
with other enzymes such lipases and esterases, can then be isolated, identified and characterised. The marine Biotechnology Centre is a key partner
in Ireland’s marine Biodiscovery Research Programme.
Areas of Expertise:
Environmental microbial Genomics
marine Biodiversity/Genetics
marine Biotechnology.
Functional metagenomics
Address
MARINE BIOTECHNOLOGY CENTRE
ENVIRONMENTAL RESEARCH INSTITUTE
University College Cork
lee Rd.
CoRK
IRElAnD
Contact detail
Alan DoBSon
Tel +353 021 4901946
a.dobson@ucc.ie
The marine Biotechnology centre has access to the following equipment- Protein, DnA, and pulsed field gel electrophoresis; Standard
and Real-time PCR, Protein analysis [HPlC, FPlC chromatography],
Proteomics [mAlDI-ToF Proteomics workstation, molecular Imager
for 2-D scanning, Phoretix Software], Genomics [mWG and Affymetrix
gene array systems Gene Director Software].
The following imaging equipment is available- Zeiss Axiophot Fluorescent microscope, Zeiss lSm510 Confocal imaging system and a Xenogen in vivo imaging system. Finally the centre has a Genetix QPIX2
XT robotic system for clonal libraries, an mWG Theonyx liquid handling robot; a multi-label plate reader and a Cytomat plate incubator.
The last major upgrade of the ERI was the QPix2 XT colony picking
robot which can pick 3000 colonies per hour and array into 96 and
384 well plate.
ACCESS PolICy
The access policy is on a case by case basis. Contact can be made via phone or
email for facilities enquiries. There is no pricelist available for the services/facilities provided by the ERI. Currently, there are two research groups using the TCF
from outside the host organisation.
www.ucc.ie
95
ALIMENTARY
GLYCOSCIENCE
RESEARCH CLUSTER
(AGRC)
location
GAlWAy, IRElAnD.
Key Words
GlyCoSCIEnCE, GlyCo-TECHnoloGy
DEvEloPmEnT, GlyCoAnAlySIS, GlyCo
mEDICInE.
The focus of the Alimentary Glycoscience Research Cluster is to develop platform
technologies to allow fundamental understanding of the interaction of complex
sugar structures with other molecules to develop novel diagnostic, therapeutic
and functional food solutions in the field of gut biology.
The Glycoscience Group at nUI Galway have significant interactions with
academics and industries worldwide on a range of glycoscience projects (cancer,
regenerative medicine, neuroscience, biomaterials) enabling it to bring a glyco
dimension to traditional areas of research with a wide variety of clinical and
industrial applications.
The targeted users for our technologies include biopharma, functional food
industries, clinical, veterinary and basic fundamental research. The group also
offers a discovery platform identifying novel glyco-biomimics allowing more specific
and tailored analysis of glycan interactions
The group is a multi-disciplinary team consisting of chemists, biochemists,
molecular biologists, microbiologists and clinicians.
Area of Expertise:
High throughput Glycoanalysis
Glyco-tool development
Glycosignature development
Glycogene transcriptomic analysis
Structure-function evaluation of natural and synthetic sugars and polymers
Functional assays for microbes to human cell lines
The Glycoscience Group provides start of the art glycoanalytical facilities and
research expertise. our platform technologies are focussed on being able to
offer high-throughput analysis of research, clinical and industrial samples. Glycan
analysis is carried out using a suite of chromatographic separation technologies
(Waters and Agilent HPlCs, Dionex HPAE-PAD, FPlC) and also by glycan
microarray. We prepare and scan our own arrays within our facility, and these
can be highly customised. We can also offer a standard set of microarrays
(lectin, Glycan, mucin and neoglycoconjugate). our discovery platform which
utilises phage display and SElEX are constantly adding to the diversity of our array
platforms, and also allow for discovery of novel biomarkers. The glycoscience
group can offer full bioinformatics support for our technologies.
Address
ALIMENTARY GLYCOSCIENCE RESEARCH
CLUSTER
national Centre for Biomedical
Engineering Science
national University of Ireland, Galway
University Road
GAlWAy
IRElAnD
ACCESS PolICy
We offer the following facilities:HPlC (Waters and Agilent)
FPlC (Akta Purifier, Akta Explorer)
Glycan Analysis (Dionex HPAEC-PAD, nmR)
Protein and Glycan microarray
Biomarker Discovery
High throughput analysis of clinical and industrial samples
Contact detail
lokesh JoSHI
Tel +353 (0)91 495768
lokesh.joshi@nuigalway.ie
Due to the nature of the highly-specialised equipment used it is not possible to
offer an open door policy for access to our equipment. Access to the facilities will
be through collaborative or service arrangements.
www.agrc.ie
96
MOLECULAR
DIAGNOSTICS
RESEARCH GROUP
NATIONAL CENTRE FOR BIOMEDICAL
ENGINEERING SCIENCE
location
Co. GAlWAy, IRElAnD
Key Words
molECUlAR DIAGnoSTIC TARGET
DISCovERy, nUClEIC ACID BASED TEST
DESIGn, nUClEIC ACID TEST PlATFoRm
TECHnoloGIES DEvEloPmEnT
The molecular Diagnostics Research Group (mDRG) has 20 years
experience and an international track record of achievement in the
development and application of molecular diagnostics tests for microbial
species identification. The mDRG has developed a suite of platform
technologies, based on proprietary nucleic acid sequence targets, for the
detection and identification of bacteria and fungi.
The mDRG has worked successfully with a number of commercial
partners to develop molecular diagnostic products for infectious diseases
based on these platform technologies.
Area of Expertise:
molecular diagnostic target discovery
nucleic acid based test design
nucleic acid test platform technologies development
Collaborative or contract R+D with industry
nucleic acid based diagnostic test design, development and validation.
Use of molecular diagnostics to analyse DnA and/or RnA in samples has
entered mainstream clinical diagnostics. Emerging markets include food,
environmental, veterinary and industrial testing. mDRG research focuses
on three application areas.
The discovery of novel molecular diagnostics targets
The design of nucleic acid diagnostics assays based on these targets
Implementation of these assays on various nucleic acid based
detection platforms.
Address
MOLECULAR DIAGNOSTICS
RESEARCH GROUP
Engineering Science
national University of Ireland - Galway
IDA Business Park
Dangan
GAlWAy
IRElAnD
Contact detail
Thomas BARRy
The mDRG has developed 3 target technologies for microbial ID which have
been commercialised through licensing agreements and collaborations
with international diagnostics companies. Examples of areas where mDRG
technologies have been applied include tests for bacterial pathogens such as
Group B Streptococcus (GBS), S. pneumoniae, S. aureus, and food pathogens
including listeria monocytogenes and Salmonella. The group has also developed
real-time PCR tests for harmful algal bloom species (HAB) that occur in Irish
waters.
mDRG has broad expertise in the integration of molecular tests on various
detection systems. These have included in vitro amplification based methods such
as PCR as well as alternative test platforms for molecular diagnostics. These nextgeneration detection platforms include novel components such as nano-particles
and quantum dots which when combined with high-copy-number RnA targets will
permit rapid «direct» detection of target organisms without in vitro amplification.
ACCESS PolICy
Services and facilities are offered on a ‘pay for use’ basis. Training is provided on
the instrumentation available at the molecular Diagnostics Facility. mDRG also
welcomes the opportunity of collaboration, academic or industry. A connection
can be made by contacting the person named below.
Tel +353 (0)91 493189
thomas.barry@nuigalway.ie
www.nuigalway.ie/mdrg
97
NATIONAL CENTRE
FOR BIOMEDICAL
ENGINEERING
SCIENCE
location
Co. GAlWAy, IRElAnD.
Key Words
mICRoSCoPy, SPECTRomETRy,
BIomECHAnICS, HIGH-THRoUGHPUT
SCREEnInG, FloW CyTomETRy,
FUnCTIonAl GEnomICS, SUPERComPUTInG
SUITES.
Establishment in 1999, the mission of the nCBES is to develop innovative
diagnostic and therapeutic solutions to biomedical challenges through
interdisciplinary and strategic research activities.
The Centre is an interdisciplinary centre of research excellence, which
brings together scientists, engineers, information technologists and
clinicians in a team-based, problem-centred approach to research.
The Centre has four major research themes.
Areas of Expertise:
Biomedical Engineering
Cancer
neuroscience
Regenerative medicine.
A particular strength of the nCBES lies in the combined skills and creativity
of a wide range of scientific, engineering and clinical disciplines working
side by side on challenging research programmes and interdisciplinary
education and training programmes. The evolution and growth of nCBES
research clusters has led to a critical mass of expertise being developed in
key areas.
The nCBES provides state of the art research facilities, expertise, and an
intellectual climate that fosters, encourages and supports interdisciplinary
research activities in Biomedical Engineering Science. The Centre’s
research facilities include microscopy, spectrometry, biomechanics and
supercomputing suites.
microscopy facilities provide some of the highest-level research equipment
available and include Confocal microscopes, a multiphoton microscope
a Scanning Electron microscope with EDX, a Transmission Electron
microscope and a Scanning Probe / Atomic Force microscope.
Address
ENGINEERING SCIENCE
national University of Ireland - Galway
University Rd.
GAlWAy
IRElAnD
Contact detail
Frank BARRy
The Biomechanics range of equipment includes Axial / Torsion Servo
hydraulic Testing System, mechanical Thermal Analyser, Fatigue and
Impact tester and Rapid Prototyping System.
The Centre has fully equipped cell culture suites in addition to flow
cytometry, , histology, high-throughput screening and functional
genomics suites. Uniquely, the nCBES incorporates the Centre for Cell
manufacturing Ireland (CCmI), which facilitates the manufacture of clinical
grade cell products.
ACCESS PolICy
If people make contact about services/facilities, nCBES would have to provide
training before external people are allowed to use it. People in industry would
either receive services or training to use the facility themselves.
Tel +353 091 495108
frank.barry@nuigalway.ie
http://ncbes.eurhost.net
98
NFB
NETWORK OF EXCELLENCE FOR
FUNCTIONAL BIOMATERIALS (NCBES)
location
GAlWAy, IRElAnD
Key Words
PolymER CHEmISTRy AnD SynTHESIS,
TREATmEnT SySTEmS, DRUG DElIvERy,
CoATInGS FoR mEDICAl DEvICES, TISSUE
REPAIR SCAFFolDS.
nFB is part of the nCBES which also includes the Regenerative medicine Institute
(REmEDI) and provides state-of-the-art research facilities to support interdisciplinary research activities in Biomedical Engineering Science.
The network of Excellence for Functional Biomaterials (nFB) produces and
develops a wide range of biomaterial platforms for use in biomedical applications
including those from natural, synthetic, ceramic, metal or combinations of all of
these. The structures may range from nano to micro and macro scale and may
be formed into fibres, sponges, gels and spheres. Functionality is added to these
forms using one custom chemistry which facilitate the attachment of surface
tethered or encapsulated therapeutic factors including drugs and genes.
The overall objective of the network of Excellence for Functional Biomaterials
(nFB) is to bring a critical mass of expertise together on a single platform to develop the next generation of biomaterials and to translate these technologies into
clinical applications.
Areas of Expertise:
Development and provision of biomaterial platforms – structural and functional
Be-spoke Biomaterials Synthesis (natural polymers, peptide mimics, chemical synthesis – responsive polymers, tissue-based biomaterials, porous
metals)
nano and microscale Structures (particles, sponges, conduits, hollow capsules, injectable hydrogels, films)
Biofunctionalisation (coatings, linking systems for cell targeting, biodelivery)
Biomaterials and Biodelivery Characterisation (biophysical – SEm, TEm; chemical – CD, nmR,mS; GPC, Zetasizer, AFm; delivery, tracking strategies;
toxicity, efficacy – cell culture, disease models)
In vivo models for Clinical Translation (nerve regeneration – peripheral and
spinal cord models; wound healing; adhesion; Parkinson’s; limb ischemia;
myocardial infarction; Huntington’s; joint and lung inflammation models)
Address
NFB
national Centre for Biomedical
Engineering Science
nUI Galway
IDA Business Park
Dangan
GAlWAy
IRElAnD
Contact detail
Abhay PAnDIT
Tel. +353 091 492758
abhay.pandit@nuigalway.ie
The nFB laboratory supports a broad range of research projects in clinical area
such as orthopaedic, cardiovascular, respiratory, soft tissue repair, neural regeneration, musculoskeletal and ophthalmic. The functionalised biomaterial based
platforms are also used in the delivery of drug and gene to affected cells.
nFB is continually developing new technologies to deliver therapeutic genes and
other biomolecules to specific target sites within the body. These include coatings
for medical devices, tissue repair scaffolds as well as programmable nanospheres which carry therapeutic agents to a specific location via the bloodstream.
These technological platforms have applications linked to cardiovascular disease,
intervertebral disc degeneration, spinal cord and peripheral nerve damage,
epidermolysis bullosa, osteochondral defects, wound healing, hernia and thoracic
wall defects, tendon regeneration, neuroinflammatory disease, pain control, lung
disease, staple line reinforcement and adipose tissue regeneration.
ACCESS PolICy
If people make contact about services/facilities, nFB would have to provide
training before external people are allowed to use them. People in industry would
receive either services or training to use the facility themselves. Charges apply to
all customers, but rates differ according to user.
www.nfb.ie
99
CCMI
CENTRE FOR CELL MANUFACTURING
IRELAND
location
GAlWAy, IRElAnD
Key Words
ADvAnCED THERAPEUTIC mEDICInAl
PRoDUCTS, ATmP, REGUlAToRy
AFFAIRS, ClEAn Room oPERATIonS,
GooD mAnUFACTURInG PRACTICE, CEll
mAnUFACTURInG.
The Centre for Cell manufacturing Ireland, established in 2003 is dedicated to producing medicinal grade human stem cells as Advanced Therapy
medicinal Products (ATmPs) for clinical trials.
The CCmI is managed by the Regenerative medicine Institute (REmEDI)
www.remedi.ie which is a biomedical research centre with a primary goal
of studying stem cell biology and translating these findings to new regenerative therapies for human disease.
The facility contains two separate production suites, allowing for the parallel manufacture of investigational medicinal products. The facility employs
personnel under the following functional areas – Quality, Facilities, and
Production.
Area of Expertise:
GmP-grade Advanced Therapeutic medicinal Products
Clean room operations
Quality management (QmS, documentation, audit, quality assurance,
quality control)
Regulatory affairs
GmP training, validation and qualification
The CCmI currently supports REmEDI’s translational research programme
with particular focus in the areas of orthobiologics (osteoarthritis, cartilage repair), diabetes and vascular disease, through the development of
GmP-grade stem cell manufacturing protocols and also the provision of
cells for clinical trials.
Current manufacturing protocols are focused on the mesenchymal stem
cell (mSC), procured from adult donors.
ACCESS PolICy
Address
Presently, the facility is used for internal research activities, or for research
collaborations with other institutes or companies. Please contact us for external
access.
CENTRE FOR CELL MANUFACTURING
IRELAND
ORBSEN BUILDING
national University of Ireland, Galway
University Rd.
GAlWAy
IRElAnD
Contact detail
Timothy o’BRIEn
Tel +353 (0)91 495166
timothy.obrien@nuigalway.ie
www.nuigalway.ie/remedi
100
SHANNON ABC
SHANNON APPLIED BIOTECHNOLOGY
CENTRE
location
lImERICK & TRAlEE, IRElAnD
Key Words
WASTE STREAmS, SCREEnInG, BIo-AnAlySIS, EXTRACTIon, DRyInG, EnRICHmEnT,
EnCAPSUlATIon, CUlTURInG, PHEnoTyPE
mICRoARRAy AnAlySIS
Shannon ABC is based in the South-West Region of Ireland and operates
from two Institutes of Technology, one based in limerick and the other in
Tralee, Co. Kerry. Shannon ABC is ideally located within the Atlantic Corridor encompassing a wide variety of Biotechnological, Food, Agricultural,
Drug and Biopharmaceutical Industries.
The key aim of Shannon ABC is to assist in the continued prosperity of
industry by offering access to wide ranging expertise and know-how, state
of the art equipment and facilities and access to a wide variety of national
and international funding programs. All collaborations respond to an industry need.
Shannon ABC offers expertise in Biotechnology, Fermentation, Purification and Identification of biologically active molecules, mammalian and
microbial Cell Culturing and testing, micro-Algae, macro-Algae, Phenotype
microArray Analysis, molecular Biology, Fungal Enzymology, Biochemistry,
Immunology, Bio-Assays, High-Throughput Screening, Extraction, Fractionation, Enrichment, Shelf life studies, Sensory Analysis, Supercritical fluid
extraction, virology, in addition to lC-mS-mS, GC-mS and Anti-oxidant, Antimicrobial and Immunomodulatory analyses.
Techniques and services offered by Shannon ABC are as follows:
Address
(1) SHANNON ABC LIMERICK
HARTNETT ENTERPRISE ACCELERATION
CENTRE
limerick IT
moylish Park
lImERICK
IRElAnD
(2) SHANNON ABC TRALEE
South Campus IT Tralee
Clash
TRAlEE
Co. KERRy - IRElAnD
Development or enhancement of biotechnological processes
Enrichment, purification and identification of natural bioactive compounds.
Generation of added value products from natural sources (eg waste
stream)
High-throughput screening
Bio-analysis
Development of extraction, drying, enrichment and encapsulation
processes
mammalian, bacterial, micro-algal and fungal culturing
Phenotype microarray analysis
ACCESS PolICy
Shannon ABC welcomes confidential collaboration with industry, academia,
research centres and researchers based nationally and internationally. We work
with our clients on a range of levels, from providing access to pieces of equipment
on a per diem basis to full collaboration on commercially directed research projects. Policies and procedures for interactions with industry and research groups
are in place. Pricelist is made available on contact with Shannon ABC.
Contact detail
Tim yEomAnS
Tel + 353 (0)61 448 545
Tel + 353 (0)66 714 4217
tim.yeomans@staff.ittralee.ie
www.shannonabc.ie
101
PoRTUGAl
MICROARRAYS
location
CAnTAnHEDE, PoRTUGAl
Key words
mICRoARRAyS, DnA, RnA, ARRAy CGH, PCR
The microarrays facility is a functional exploration facility to develop DnA
microarrays studies which can be used to monitor DnA copy number
variation and RnA expression. It is an open platform with skilled human
resources, equipped with state of the art robotized technologies for high
throughput analysis and specialized in microarrays for gene expression,
Chromosome stability (Array CGH) and microarray printing.
This TCF is aiming to supply research groups and hospital services
and offers professional services in: RnA/DnA quality analysis using
Bioanalyzer; Printing of microarrays; cDnA production; DnA extraction;
microarray scanning; labeling DnA with fluorophores; Hybridization of
microarrays; Analysis of results and Confirmation using real-time PCR.
located in Biocant, Cantanhede, since 2006, occupies a surface of 150
m2 in the research center of Biocant.
The microarrays platform services include gene expression studies;
analysis of genetic viability within populations; chromosome stability studies
and microarrays data analysis.
In order to deliver service excellence, this TCF has made some upgrades,
the latest was the acquisition of the bioanalyzer equipment which further
increased the sensitivity and the resolution (allows analyzing smaller
amounts of DnA and smaller fragments) and the upgrade of the Real-Time
PCR for 7500-Fast (Applied Biosystems).
This unit has confidentialy agreement with all its collaborators which can
also be expended, when needed, to the external users.
ACCESS PolICy
There is an initial contact with responsible person for the unit where the
experimental design is discussed and the access conditions are defined. Service is
provided on a fee per service basis.
This unit has confidentiality agreements with all its collaborators which can also
be extended, when needed, to the external users.
Address
BIOCANT
Parque Tecnológico de Cantanhede,
núcleo 04, lote 3
3060-197 CAnTAnHEDE
PoRTUGAl
Contact detail
Ana Catarina GomES
Tel. (+ 351) 231 419 040
acgomes@biocant.pt
www.biocant.pt
103
BIOINFORMATICS
location
Key words
BIoInFoRmATICS, DATA AnAlySIS,
BIoSTATISTICS, SoFTWARE DEvEloPmEnT
The Bioinformatic Platform works at the interface between computer
science and biomedical science. This Unit joins computer science
engineers with experienced in biomedical problems with expertise in the
development and usage of software.
The Bioinformatics Platform services include the development of custom
scientific computing tools, consultation, data analysis and training and
hosts a suite of scientific computing resources such as algorithms,
programs, databases and websites.
located at the Biocant and operating since 2005, this applied
bioinformatics platform aims establishing solid collaborations with private
and public institutions operating in biological or health fields.
The developed work involves the analysis of de novo sequencing and resequencing, sequence analysis and its annotation, SnPs, transcriptomes,
metagenomes, plus the analysis of large amounts of information,
database design and specific software to the scientific area covered by
bioinformatics.
Its latest update, in terms of equipment, was the acquisition of a cluster
computer.
ACCESS PolICy
An initial contact may be required to get access to services provided by the unit.
The prices will be adjusted to the project presented.
This unit has confidentiality contracts with all its collaborators which can also be
extended, when needed, to the external users.
Address
BIOCANT
Parque Tecnológico de Cantanhede
núcleo 04, lote 3
3060-197 CAnTAnHEDE
PoRTUGAl
Contact detail
miguel PInHEIRo
Tel. (+ 351) 231 419 040
monsanto@biocant.pt
www.biocant.pt
104
MOLECULAR
BIOTECHNOLOGY
location
Key words
molECUlAR BIoTECHnoloGy,
HETERoloGoUS PRoTEIn
EXPRESSIon,yEAST, E. Col, PCR,
REComBInAnT DnA, PRoTEASES, PRoTEIn
CHARACTERIZATIon
molecular Biotechnology is directed towards the discovery and production
of proteins with biotechnological interest with application in the biomedical
area or in the food and agriculture industry.
located in Biocant, this unit joins a research team with accumulated
know-how in the field of molecular biotechnology and protein expression
and purification processes.
The platform is based in molecular biology and recombinant DnA
technology, as well as enzymology and protein chemistry techniques for
expression, purification and characterization of recombinant proteins or
purification and characterization of proteins from natural sources.
This unit aims establishing partnerships with public or private
organizations in order to develop new protein/peptide products for new or
improved biotechnological applications.
The molecular Biotechnology Unit is equipped with modern equipment.
Its services include: heterologous production (in E. coli and also in GRAS
organisms), purification and characterization of recombinant proteins;
protein labeling for structural studies; random and directed mutagenesis;
production and screening of genomic and cDnA libraries; purification and
characterization of proteins from natural sources.
The services can be applied in the amplification of genes or specific coding
sequences; in protein engineering studies of point mutations, deletions or
insertions of specific nucleotide sequences; to modify synthetic vectors
by cloning and mutagenesis approaches; in the expression, purification
and characterization of recombinant proteins using E. coli and yeast as
heterologous expression systems; in the characterization of new enzyme
activities.
ACCESS PolICy
Address
BIOCANT
núcleo 04, lote 3
3060-197 CAnTAnHEDE
PoRTUGAl
All equipment can be used by other research units of Biocant, by private
companies installed in the Biocant Park and by research groups according to the
established general rules of the Institute. Companies have to pay the established
fees for each equipment. The use by any external user has to be submitted to
prior approval.
This unit has confidentiality agreements with all its collaborators, which can also
be extended when required to external users and clients.
Contact detail
Isaura SImÕES
Tel. (+ 351) 231 419 040
isimoes@biocant.pt
www.biocant.pt
105
MASS
SPECTROMETRY
/ PROTEOMICS
location
Key words
PRoTEInS, mETABolITES, PRoTEomICS,
mETABolomICS, mASS SPECTRomETRy
mass Spectrometry / Proteomics unit is specialized in the identification
and quantification of proteins from complex samples, identification of posttranslational modifications, and identification and quantification of drugs
and metabolites.
We also work on biomarker identification through proteomic and
metabolomic techniques with the purpose of developing new prognosis
and diagnosis methods. It has one of the most sensitive equipment
operating in Portugal. It is member of Portuguese national mass
Spectrometry network.
The mass Spectrometry / Proteomics unit offer access to techniques
such as identification of proteins and peptides and proteomics that can be
used to study the modification of proteins and metabolites as a result of
using different drugs.
our team has also been involved in masters and PhD courses with
the Chemistry department–University of Coimbra(UC), and CnC-UC,
respectively.
ACCESS PolICy
Access to this technology platform is done through the provision of services and
collaborations.
All information is available via web site including a service request form (http://
cnc.cj.uc.pt/~proteome/Services_and_RnEm.htm ). This TCF has confidentiality
procedures, all collaborators have a confidentiality agreement extensible to
external users.
Address
BIOCANT
núcleo 04, lote 3
3060-197 CAnTAnHEDE
PoRTUGAl
Contact detail
Bruno mAnADAS
Tel. (+ 351) 231 419 040
bmanadas@gmail.com
http://cnc.cj.uc.pt/~proteome
106
CELL CULTURE
location
Key words
CEll CUlTURE, STEm CEllS,
mESEnCHymAl STEm CEllS (mSCS);
TISSUE CUlTURE
The Cell Culture facility is specialized in cell culture in general, isolation
of stem cells from the umbilical cord, cell viability assays and cellular
characterization.
Its mains advantages are the flexibility relative to new applications and
development of custom cell-based solutions to answer specific questions.
This platform offers cell culture, permanent genetic manipulation of cells,
cell toxicity studies for new drugs; tissue sensitivity to new drugs, studies
on cell survival factors and others, enabling the understanding of the
mechanisms of action of new drugs in human or animal cells.
This represents good opportunities for new developments in medicine and
pharmaceutical sciences.
located in Biocant, Cantanhede, this facility has tissue culture rooms and
cutting edge equipments.
The main expertise of the Cell Culture facility is the isolation and culture
of stem cells from human umbilical cord. other related techniques, like
fluorescence microscopy are also available. Its latest upgrade was a flow
cytometer that allow cell characterization by flow cytometry.
ACCESS PolICy
The access to this platform may be direct or through service provision. All
interested should contact the unit and each request will be analyzed individually.
The access is done under variable rates.
The flow cytometer and the fluorescence microscope may be used directly by
experienced users under fee payment. The remaining techniques, namely cell
culture, are available as a service developed by in house scientist. This unit has
confidentiality agreements with all its collaborators which can also be extended,
when needed, to the external users.
Address
BIOCANT
núcleo 04, lote 3
3060-197 CAnTAnHEDE
PoRTUGAl
Contact detail
mário GRãoS
Tel. (+ 351) 231 419 040
mgraos@biocant.pt
www.biocant.pt
107
DNA GENOTYPING
location
Key words
DnA, GEnoTyPInG, GEnE EXPRESSIon,
SEQUEnCInG
DnA Genotyping facility aims to supply large scale services to public
organizations and companies and is specialized in the determination DnA
modifications. It is a platform that offers services in large-scale DnA sequencing using next generation sequencing, SnP detection, gene expression and bioinformatics.
located in Biocant, is distinguished by the expertise of its team, by the use
of different state of the art technologies to detect DnA modifications at
individual level or in populations and by aggregating several equipments
with high level of responsiveness and data processing.
The DnA genotyping is based in molecular biology techniques like PCR and
RT-PCR, next generation DnA sequencing, SnP detection through classical techniques or Taqman detection.
Its last major upgrade was the introduction of new equipment, a Taqman
- openArray - Genotyping Instrument Platform (Applied Biosystems), and
the implementation of bioinformatics applications to guide the selection of
relevant and informative SnPs.
ACCESS PolICy
External users don’t have direct access to the equipment but can use them
through service provision or collaboration.
Demands can be submitted by e-mail, by phone or in person. Requests are
analysed and the programmed approach discussed with the client to adjust the
experience design with the costumer objectives.
There are confidentiality procedures, all collaborators have confidentiality agreements with the Institution which can also be established with the external users.
Address
BIOCANT
núcleo 04, lote 3
3060-197 CAnTAnHEDE
PoRTUGAl
Contact detail
Conceição EGAS
Tel. (+ 351) 231 419 040
genoinseq@biocant.pt
www.genoinseq.com
108
ADVANCED
SEQUENCING
SERVICE
location
Key words
DnA SEQUEnCInG, GEnomES,
TRAnSCRIPTomE, mETAGEnomE
The Advanced Sequencing Services unit is specialized in the area of DnA
sequencing of next generation and is focused in applications in a wide
range of fields: de novo sequencing or resequencing of genomes through
whole genome shotgun sequencing, transcriptome sequencing, ultra-deep
sequencing of tumour or viral samples, resequencing of genes/exons,
metagenomics and biodiversity studies; gene regulation studies by small
non-coding RnA or CHIP-sequencing and epigenetics.
This facility is located in Biocant and its main advantages are the team
with accumulated know-how and experience in several areas of intervention; the high capacity to provide consulting services, embracing projects,
planning experience and data processing and analysis.
The services are based in the Genome Sequencer FlX, by Roche-454 life
Sciences and SolID 5500xl, by life Technologies. We also offer access to
data analysis and biostatistics and sequence analysis, providing access to
large scale data interpretation.
ACCESS PolICy
Sequencing Advanced Services offers access to next generation sequencing to
companies and public organizations on a fee-per-service basis. Demands can be
submitted by e-mail, by phone or in person. Requests are analysed and the programmed approach discussed with the client to adjust the experience design with
the costumer objectives.
There are confidentiality procedures, all collaborators have confidentiality agreements with the Institution which can also be established with the external users.
Address
BIOCANT
núcleo 04, lote 3,
3060-197 CAnTAnHEDE
PoRTUGAl
Contact detail
Conceição EGAS
Tel. (+ 351) 231 419 040
genoinseq@biocant.pt
www.genoinseq.com
109
ELISA & MULTIPLEX
location
Key words
ElISA, mUlTIPlEX, BIomARKERS
The ElISA & multiplex facility is specialized in the quantification of biomarkers, especially proteins in tissues and fluids.
The main advantage of the ElISA system includes high sensitivity and
broad wavelength detection range (200 to 999nm) and all ancillary equipment for plate processing. The multiplex xmAP technology (Bio-PlexTm/
luminex®) presents superior sensitivity (fluorescence-based technology)
and allows the simultaneous identification of multiple analytes in samples
with reduced volume.
The ElISA platform allows the utilization of virtually all commercial kits in
the market, due to the broad wavelength range of the equipment. The multiplex xmAP technology is currently being developed by distinct partners,
enlarging the analytes portfolio every year, ranging from cytokines detection, disease specific markers or signaling proteins. Kits are available for
human, mouse and rat samples applications.
ACCESS PolICy
The access to the ElISA platform may be direct or thought service provision.
The multiplex xmAP techniques offered are available as a service by in house
scientists. All interested should contact the unit and each request will be analyzed
individually. The access is done under variable rates. This unit has confidentiality
agreements with all its collaborators which can also be extended, when needed, to
the external users.
Address
BIOCANT
núcleo 04, lote 3
3060-197 CAnTAnHEDE
PoRTUGAl
Contact detail
mário GRãoS
Tel. (+ 351) 231 419 040
mgraos@biocant.pt
www.biocant.pt
110
FOOD SCIENCE AND
BIOCHEMISTRY
location
AvEIRo, PoRTUGAl
Key words
AGRIFooD, EnZymES, PolySACCHARIDES;
BIomolECUlES, HIGH PRESSURE,
InSTRUmEnTAl TECHnIQUES
Food science and biochemistry facility specialized in: i) characterization
of polysaccharides, proteins, enzymes and volatile compounds; ii)
characterization of bioactive components from sub-products and nonfood sources; iii) instrumental analysis: FTIR, nIR, GC-mS, GC × GC-ToFmS, and electronic aroma detection for analysis and characterization of
food products, and iv) high pressure for non-thermal pasteurization and
modification of food products, enzymatic activity and biopolymers; owing a
“Technological Research Platform in High Pressure” with 3 equipments, 2
at laboratory scale and a third with controlled temperature at pilot scale.
Aims to supply services to companies and public organizations through its ability
of using advanced instrumental techniques to characterize biomolecules, and
monitor changes during biological or technological processes. The Technological
Platform in High Pressure is devoted to research and development with the
industry
located in the University of Aveiro, this facility occupies a surface of 250m2 and is
member of InTEGRAlAR Association - excellence intervention program in Agrifood.
Address
DEPARTAMENTO DE QUÍMICA
Campus Universitário de Santiago
3810-193 AvEIRo
PoRTUGAl
Contact detail
Ivonne DElGADIllo
The services offered by this platform include:
Structural analysis of biomolecules with emphasis in polysaccharides
and other bioactive molecules to be used as nutraceutical or new
ingredients, from raw products or their by-products.
Application of the instrumental techniques mentioned above to monitor
the biochemical or physical-chemical modifications of food components
due to biological maturation, food processing and/or storage. The
information acquired may also be used for developing quality control
methodologies.
Analysis of volatiles of fresh and processed products: fruits, wine,
coffee, etc. The latest major up-grade was the acquisition of GC x GC Tof-mS equipment which allow the analysis of very ultra-low quantities
of natural components and contaminants.
Development of edible films and nanoencapsulation of bioactive
products
Data treatment by means of development of software for multivariate
analysis of instrumental data.
Application of high pressure for cold pasteurization, control of
enzymatic activity, modification of texture properties from food
products, polysaccharides and proteins.
Use of high pressure equipment for research and development.
ACCESS PolICy
Demands can be submitted by e-mail, by phone or in person.
There are confidentiality protocols.
Tel. (+ 351) 234 370 718
ivonne@ua.pt
www.ua.pt/dq/PageText.aspx?id=5241
111
LABORATORY FOR
HIGH-RESOLUTION
CELL BIO-IMAGING
location
CoImBRA, PoRTUGAl
Key words
ConFoCAl mICRoSCoPy, FlUoRESCEnCE
mICRoSCoPy, lIvE CEll ImAGInG,
TRAnSmISSIon ElECTRon mICRoSCoPy,
TISSUE SECTIonInG
The laboratory for High-Resolution Cell Bio-Imaging aims to develop
scientific research but is also able to provide support to companies and
research groups in its R&D projects.
This lab offers access to cutting edge techniques and equipments, including a confocal microscope, a fluorescence microscope (both allowing live
cell imaging), a transmission electron microscope (TEm), a cryostat for
sectioning of biological samples in oCT and a ultramicrotome with a cryogenic unit for sectioning of frozen samples.
The team has accumulated vast know-how and expertise on the area and
can provide consulting services. located in the University of Coimbra, this
laboratory is part of the national network of Electron microscopy.
The laboratory for High-Resolution Cell Bio-Imaging offers access to
techniques such as: (i) fluorescence, confocal and electron microscopy
that can be applied in experiments of co-localization of proteins by immunofluorescence, experiments of live cell imaging and in vivo protein trafficking
(i.e. by the use of fluorescent tags like GFP, mCherry, yFP), fluorescence
recovery after photobleaching (FRAP), 3D reconstruction (Z Stacks) of cellular structures/tissues, immunoEm and conventional Em; crio-sectioning
and oCT sectioning.
ACCESS PolICy
The microscope systems are available to all researchers. Service fees can be
found at http://www.uc.pt/fmuc/plataformastecnologicas/labBCAR.
Interested users should contact the lab before planning experiments.
Adequate training in the handling of the equipments is provided. Scheduling follows
the rules described in the lab website.
Address
PÓLO III – PÓLO DAS CIÊNCIAS DA SAÚDE
IBIlI, Azinhaga de Santa Comba, Celas
3004-535 CoImBRA
PoRTUGAl
Contact detail
Henrique GIRão
Tel. (+ 351) 239 480 221
hmgirao@fmed.uc.pt
www.uc.pt/fmuc/plataformastecnologicas/labBCAR
112
STRUCTURAL AND
COMPUTATIONAL
BIOLOGY
LABORATORY
location
CoImBRA, PoRTUGAl
Keywords
nUClEAR mAGnETIC RESonAnCE,
CIRCUlAR DICHRoISm, STRUCTURAl
ComPUTATIonAl BIoloGy, DISTRIBUTED
ComPUTInG
The Structural and Computational Biology laboratory is formed by biochemists, chemists, molecular biophysicists and bioinformaticians, and
has a track record in the fields of nmR (nuclear magnetic resonance),
CD (circular dichroism), fluorescence and computer simulations to study
protein structure, stability, folding and aggregation, and protein-ligand
interactions.
It is strategically focused on the use of experimental and computational
methodologies to study the molecular basis of amyloid diseases, with a
significant effort being made in the area of virtual screening and rational
design of inhibitors of amyloidosis with the goal of developing new therapeutic agents.
The group is also working on the structural modeling of viral proteins with
the goal of developing new anti-viral agents.
This laboratory is a member of Partnership for Advanced Computing in
Europe (PRACE); Instruct: An Integrated Structural Biology Infrastructure
for Europe; and Ibercivis: A volunteer computing platform.
The Structural and Computational Biology laboratory offers access to
cutting edge equipments for the structural characterization of proteins
and peptides:
nuclear magnetic Resonance: Bruker Avance III 400 mHz nmR spectrometer equipped with a UltraShield Plus magnet, 3 radio-frequency
channels, field gradients in zz, auto-sampler, 5 mm broad band
(BBFo) probe, and 5mm triple resonance (TXI) probe.
Circular Dichroism: olIS DSm-20 CD spectropolarimeter operating
in the Uv-visible spectral region, equipped with a Peltier temperature
control unit allowing programming of heating and cooling ramps.
Software for CD spectra analysis, including determination of relative
composition in secondary structure of a protein sample. optical cells
with pathlengths ranging from 0.2 to 10 mm are available.
The laboratory also offers expertise in structural bioinformatics namely in
virtual high throughput screening (vHTS), protein docking, protein modeling and database management and construction.
Address
DEPARTAMENTO DE QUIMICA
Universidade de Coimbra
Rua larga
3004-535 CoImBRA
PoRTUGAl
ACCESS PolICy
Requests should be submitted by e-mail (rbrito@ci.uc.pt) and each request will
be analyzed individually. All information is available via web site including a service
request form (http://www.uc.pt/fctuc/dquimica/rbritolab/resources/).
Contact detail
Rui BRITo
Tel. (+ 351) 239 854 451
rbrito@ci.uc.pt
www.uc.pt
113
BLUEWORKS
location
CoImBRA, PoRTUGAl
Key words
SoFTWARE DEvEloPmEnT, DATA AnAlySIS,
SySTEm InTEGRATIon, oPHTHAlmoloGy
BlueWorks - medical Expert Diagnosis is a technological start-up devoted
to the development of engineering solutions to support clinical practice
and research.
our services are related to custom-development of ICT for Health,
including interfaces for clinical records, interoperability with
complementary diagnosis exams, and image & signal processing.
our software is able to automate data collecting procedures for devices
with limited communication capabilities.
We are certified within the scope of good practices for Research,
Development and Innovation (nP 4457:2007 - Portuguese norm for
the Research, Development and Innovation) and is a member of DHmS Regional dynamization of actors in area of HealthCare & medical Solutions.
We use different approaches to capture equipment output,
either from low-level ones (serial ports, s-video, RCA) or high-level
(connection to database, interpretation of proprietary-format files,
standard formats such Xml, Hl7, DICom, etc.).
Additionally, for given image outputs that depict textual information,
we are able to recognize and retrieve this textual and numerical
information, storing it into organized tables and data-sets.
ACCESS PolICy
Demands should be submitted by e-mail, and the discussions might be held within
the scope of a nDA.
Address
BLUEWORKS
Rua D. manuel I, 92
3030-320 CoImBRA
PoRTUGAl
Contact detail
Paulo BARBEIRo
Tel. (+ 351) 239 791 090
pbarbeiro@blueworks.pt
www.blueworks.pt
114
IMAR
INSTITUTO DO MAR - INSTITUTE OF
MARINE RESEARCH
location
CoImBRA, PoRTUGAl
Key words
mARInE SCIEnCE, EnvIRonmEnT
ImAR is structured as a network of resarch centers, aiming to contribute
to the scientific basis of policy support, to establish and promote key areas
of scientific research on a multi-year scale. It is speclized in environmental
quality assessment, maritime economy, ecosystem services, risk analysis,
optimization, hydraulics and water resources and environment, european
marine strategy.
This platform is located in University of Coimbra, University of évora and
new University of lisbon offer services such as environmental quality
analysis. Its team gathers specialized researchers belonging to institutions
from all over the country, and covers the majority of research areas in
marine Science and Technology.
The ImAR facility offers access to bioinformatics techniques like data
storage, data analysis and biostatistics, system modelling (biological
processes, ecosystems,etc.), and other techniques such as color analysis
of water quality parameters, chromatography ( gas, ionic, of liquid phase),
carbon and total nitrogen, ergosterol extraction, and water-resources
optimization.
With cutting edge equipments, the latest upgrade of this facility was the
acquisition of an analyzer isotropic and a multiparameter analyser of water
quality.
ACCESS PolICy
Demands should be submitted according the procedures on-line indicated.
If requested there are confidential agreements available.
Address
IMAR
Instituto do mar
c/o Department of life Sciences
University of Coimbra
3004-517 CoImBRA
PoRTUGAl
Contact detail
João Carlos mARQUES
Tel. (+ 351) 239 836 386
jcmimar@ci.uc.pt
www.imar.pt
115
CIENGIS
SISTEMAS DE CONTROLO
AVANÇADO, SA
location
CoImBRA, PoRTUGAl
Key words
PRoCESS SImUlATIon, ConTRol AnD
oPTImIZATIon, BIoDIESEl, BIomASS,
BIoEnERGIES, SoFTWARE DEvEloPmEnT
Ciengis is an award-winning high-tech company that provides advanced
process control and monitoring.
This platform offer services of implementation of advanced control
systems and dynamic optimization. Based in custom-tailored solutions
that services can be applied to a vast number of process industries,
namely chemicals and petrochemicals, polymers, food and beverage, pulp
and paper and bioenergies. Its team with accumulated know-how and
experience has high capacity to provide consulting services.
Ciengis’ products are: Plantegrity - a nonlinear model predictive control
system, Plantstreamer Portal - a process data historian system with
analysis, visualization and reporting capabilities.
Ciengis’ services include the data storage its analysis and reporting ,
system modelling of process systems, deployment of advanced process
control and optimization systems, process systems engineering,
customized software development, for instance of biodiesel production
sites.
ACCESS PolICy
Demands can be submitted by e-mail, by phone or in person. Requests are
analysed and the programmed approach discussed with the customer to adjust
the experience design with the costumer objectives.
There is confidentiality procedures, all collaborators have confidentiality
agreements with the organization which may also be established with the
external users. This platform complies with industrial ownership rules.
Address
CIENGIS
IPn, Rua Pedro nunes
3030-199 CoImBRA
PoRTUGAl
Contact detail
Andrey RomAnEnKo
Tel. (+ 351) 239 700 353
andrey.romanenko@ciengis.com
www.ciengis.com
116
LABORATORY
FOR ADVANCED
COMPUTING
OF THE UNIVERSITY OF COIMBRA
location
CoImBRA, PoRTUGAl
Key words
DATA SToRAGE, ComPUTInG PoWER,
SoFTWARE DEvEloPmEnT
The laboratory for Advanced Computing of the University of Coimbra
(UC-lCA) aims to provide advanced computing resources for research
in physics, chemistry, applied mathematics, engineering and biological
sciences to research groups and companies.
This laboratory is specialized in advanced computing, configuration,
installation and management of advanced computer systems and
implementation of software applications in a computer cluster
environment.
It has experience in providing computer resources allocation through open
calls for scientific projects and organizes advanced computer workshops.
In particular there is experience in deploying and using parallel computer
codes used in simulations of biological molecules like nAmD, GRomACS
and AmBER.
located in the Physics Department of University of Coimbra, the laboratory
has supported scientists from 9 Portuguese Universities and 2 research
laboratories. It is a member of the European Research Infrastructure
PRACE (Partnership for Advanced Computing in Europe).
UC-lCA computer systems include the 520-core Computer cluster
milipeia and the recent 128-core computer cluster Centaurus, which
includes 7 high-performance Graphics Processing Units .
The simulations run on these clusters include structural analysis,
molecular modelling, and system modelling of biological processes. In
particular, the application software installed and the computer power
available has allowed the scientists who use the clusters to study protein
folding/unfolding, molecules with pharmaceutical interest, carry out
simulations of some biological processes like angiogenesis, study biological
markers and perform computer simulations of neutron and proton
radiobiology treatments.
ACCESS PolICy
Address
LABORATORY FOR ADVANCED
COMPUTING
Physics Department
of the University of Coimbra
3004-516 CoImBRA
PoRTUGAl
Access to the computer cluster milipeia is granted through national calls for
scientific projects that use advanced computer resources. There is at least one
call per year.
The accepted projects are allocated a number of core hours depending on the
merit and past usage. Each year are allocated around 4.5 million core hours.
Contact detail
Pedro AlBERTo
Tel. (+ 351) 239 410 116
pedro@fis.uc.pt
www.lca.uc.pt
117
LABORATORY FOR
BIOSTATISTICS
AND MEDICAL
INFORMATICS
location
CoImBRA, PoRTUGAl
Key words
DATA AnAlySIS SoFTWARE
DEvEloPmEnT, BIoSTATISTICS
The laboratory for Biostatistics and medical Informatics offers
consultancy in statistical analyses and development of scientific
computing tools for biomedical problems, namely those related to
pharmacoepidemiology, genomics, bioinformatics and imaging. Additional
services include research, education and training.
The laboratory is a part of IBIlI, a research Institution of the Faculty of
medicine of the University of Coimbra, which relies on excellent clinical
and laboratory facilities as well as on a highly skilled and multidisciplinary
scientific staff. IBIlI is an internationally recognized centre of excellence for
research in health sciences.
Examples of application : consultancy in biostatistics, design of clinical
trials, epidemiological studies, farmacoeconomy studies, clinical services
organisation, courses in biostatistics and biomedical computing.
ACCESS PolICy
Contact by e-mail.
Address
LABORATORY FOR BIOSTATISTICS AND
MEDICAL INFORMATICS
Azinhaga Santa Comba, Celas
3000-548 CoImBRA
PoRTUGAl
Contact detail
Claudia CARIDADE
Tel. (+351) 239 480 240
acaridade@fmed.uc.pt
www.uc.pt
118
SICGEN
ANTIBODIES
location
CoImBRA, PoRTUGAl
Key words
PolyClonAl AnTIBoDIES
SICGEn taking advantage of cutting-edge technologies is committed
to developing itself to the world’s provider of polyclonal antibodies and
antibody related products and services with the best quality and the most
competitive-edge prices.
As a customer service we offer the production of polyclonal antibodies
from goat to the scientific community. It is both a product and a service
company and its primary line of business is the discovery and marketing
of new for research and scientific purposes. SICGEn has been producing
custom polyclonal antibodies for major national and International
Universities, Research Institutions and pharmaceutical manufacturers
worldwide.
The facility includes a licenced animal house (goats) and a laboratory
facility for serum preparation and storage.
ACCESS PolICy
Services are accessible for any academic and private projects. The demands are
submitted to the core facility director by e-mail. Then the strategy is defined and
the experiments are conducted according to the required specifications. The fee
depends on the services provided.
Address
SICGEN
Estrada do Pombalinho
Rabacal
3230-544 PEnElA
PoRTUGAl
Contact detail
José RAmAlHo
Tel. (+351) 919145219
jramalho@sicgen.pt
www.sicgen.pt
119
CCMAR TCF
CENTRO DE CIENCIAS DO MAR
DO ALGARVE
location
FARo, PoRTUGAl
Key words
AQUACUlTURE PIloT STATIon;
ElECTRoPHySIoloGy; EnvIRonmEnT
monIToRInG AnD DISRUPToRS;
ImmUnoASSAyS; molECUlAR BIoloGy
AnAlySIS; BIoEnERGy; mICRoBIoloGy;
PRoTEomICS
CCmAR technologies and services can provide custom made solutions
covering a range of domains: marine Sciences; Blue Biotechnology;
Biological and Environmental Sciences; Ecology and Biodiversity. Services
include Techniques and Analysis, Scientific Diving and Consultancy and
R&D Services. Consultancy and R&D Services are available upon request
and a multidisciplinary team can be assembled to respond to specific
technical problems.
End-users include marine biologists, in-house staff, researchers from other
scientific domains from universities, government and nGo agencies, SmEs
and industry.
The TCF is staffed by technical experts who focus entirely on service
provision; there is a multidisciplinary team that supplies a highly specialized
set of services with the primary aim of satisfying the needs of TCF users.
Specialised services are run by a Head of the Facility with responsibility for
daily operations and quality assurance. Primary objectives are; i) quality of
services; ii) fast reaction times to user demands; iii) an affordable price;
and iv) when possible an integrated solution.
Organizational Structure
The TCF is segmented according to the available infrastructures and
capabilities.
CCmAR R&D facilities consist of equipped laboratories, Technological
Platforms that provide access to equipment and analytical services, an
experimental marine station, Ramalhete, Boats and a Scientific Diving
Centre.
The Ramalhete Experimental marine Station is equipped with aquarium
facilities and marine biological models and all the technical expertise for
running trials or experiment.
In order to undertake outdoor and on site experimental actions, the
TCF provides access to the Ria Formosa and adjacent Coastal Area
Ecosystems. There are boats available for R&D activities and a Scientific
Diving Centre to support underwater experimentation and collection of
organisms.
Consultancy and R&D Services are also available in a wide range of
expertise provided by multidisciplinary teams.
Address
CCMAR
Centre of marine Sciences
University of Algarve, building 7
8005-139 FARo
PoRTUGAl
Contact detail
liliane lEmAn
Routine Analysis and Techniques
Quantification of Herpes virus in Seed oysters Using PCR technique
DnA Sequencing
Identification of plant or animal species used for the confection of
processed foods, such as cod pastries.
lleman@ualg.pt
120
DnA Fragment Analysis
Widely used method in studies of population genetics and these methods are also used in
paternity testing.
Elemental Analysis (C, H, n)
a) Identification of sources of nutrients, natural or anthropogenic, that exists in riverine
ecosystems, estuarine, and coastal
b) monitoring the uptake of different sources of nutrients for primary producers (plants
and algae)
c) Quantification of Protein and Biomass in biological material
Gas Chromatography – mass Spectrometry (GC/mS)
Environmental analysis, food analysis, flavour and aroma applications, industrial
measurements, advanced diagnostic methods.
High-Performance liquid Chromatography (HPlC)
Environmental tests, chemical, pharmaceutical and food industries, among others, for the
separation, quantification and detection of compounds (eg. Drugs)
Proteomics
Study the pattern of accumulation of a specific protein at the cell level.
Bacteria Identification
Food industry, environment or healthcare.
Hormonal Immunoassays – RIA, ElISA, Western blot
Extraction of analytes from tissue or fluid, fresh or frozen samples.
Isolation and identification of steroids by thin layer chromatography and mass
spectrophotometry.
Development of custom immunoassay, development of specific radiotracers, and
quantification of analytes in plasma, urine, tissue extracts and environmental water.
ACCESS PolICy
Access is granted to internal users and users from other R&D institutions, nGo, Government institutions
and also companies. Access is available for Technological Platforms, Ramalhete Experimental Station,
model organisms and Boats and on specific requests to R&D laboratories.
Services are available through several mechanisms: Requisition, Service supply contract, Collaborative
agreement or Access to infrastructures agreement.
www.ccmar.ualg.pt
121
CIIMAR
CENTRO INTERDISCIPLINAR
DE INVESTIGAÇÃO MARINHA E
AMBIENTAL
location
PoRTo, PoRTUGAl
Key words
EColoGy, EnvIRonmEnT, ECoToXIColoGy,
CoASTAl AREAS, RESEARCH, GEnomICS,
BIoInFoRmATICS, BIoCHEmISTRy, AQUATIC
RESoURCES
CIImAR has as main purpose the research and technological development
that contributes to the comprehension of the biological, chemical and
physical processes that are occurring in the ocean and in the environment.
many of the techniques used in the services are developed in CIImAR
so we are able to offer up to date applications our the most modern
metodologies. Services include physical oceanographic stuidies and
GIS, environmental impact assessement, monitoring and management
plans of inland and costal ecossystems, environmental risk analysis
of xenobiotics and natural toxins, evaluation of welfare and sanitation
of aquacultural systems, enhancement of production in aquaculture;
ecological and ecotoxicological studies in freshwater, estauarine and
marine environments.
The main users are Water and Wasterwater Treatment Plants, ministry
of Environement, ministry of Health, Water Institute, Fish Food industry,
municipalities, Public Health Centres, Pharmaceutical and Chemical
Industry, other research centres.
Prediction of currents, temperature, salinity and waves formation
in the oceanic and costal areas, characterization of fauna and flora
of a costal areas in order to define locations for industrial activities,
recreational sites or foshing areas; ecotoxicological evaluation of new
pharmaceuticals or agricultural products;
evaluation of the efficiency of a WTP in order to remove phytoplankton
and toxins from cyanobacteria;
analysis of fish parasites in aquaculture species or in wild caught
animals;
formulation of new fish diets that enhance production and decrease
environmental impact.
ACCESS PolICy
Services may be arranged by direct contact with the laboratories in charge of the
techniques in question or by contact to the CIImAR secretariate.
Address
CIIMAR
Rua dos Bragas, 289
4050-123 PoRTo
PoRTUGAl
Contact detail
João CoImBRA
www.ciimar.up.pt
joao.coimbra@ciimar.up.pt
122
CBME/UALG
ANIMAL FACILITY
location
FARo, PoRTUGAl
Keywords
AnImAl moDElS, AnImAl
EXPERImEnTATIon, STUDIES
This TCF is a conventional facility for the housing of laboratory mouse
strains under “Specific Pathogen Free” (SPF) conditions and consists of 4
units:
Two independent rooms for the housing of the animals (5.000);
one experimental room, equipped for small surgeries and dissections;
one support room, for cleaning, washing and sterilization of cages,
food and bedding;
Technical support for animal health and welfare (mDv, as by line d) of
nº37 Portuguese Portaria 1005/92).
As services, the CBmE/UAlg Animal Facility may provide Breeding
small numbers of mouse “inbred” strains, namely C57/B6 and 129/
Sv;
Breeding and housing of genetically modified mouse strains;
Technical and scientific advice to investigators planning to design
genetic manipulation experiments using mouse models;
Biomedical, pharmacological, toxicity, etc. studies for external entities
upon request and contract.
The techniques used are animal models and infrastructure for animal
experiments. CBmE/UAlG Animal Facility also use imaging techniques in
particular ultrasound.
ACCESS PolICy
The access to this platform is allowed through the following procedures:
Submission of Cv and presentation of the project by the researcher concerned.
Then this information is examined by the Ethics Committee of the CBmE/UAlG
Animal Facility and if the evaluation is favorable, the person responsible proceeds
to form to veterinary Authority.
Address
UNIVERSITY OF ALGARVE
FCT Bld. 8
Campus de Gambelas
8005-139 FARo
PoRTUGAl
Contact detail
Sara mARQUES
Tel. (+ 351) 289 800028
slmarques@ualg.pt or cbme@ualg.pt
www.cbme.ualg.pt/bioterio_cbme.html
123
CEBAL
CENTRO DE BIOTECNOLOGIA
AGRÍCOLA
E AGRO-ALIMENTAR
DO BAIXO ALENTEJO E LITORAL
location
BEJA, PoRTUGAl
Keywords
AGRICUlTURAl BIoTECHnoloGy, AGRoFooD BIoTECHnoloGy, RECovERy oF
BIomASS
CEBAl has focused in the recovery of biomass from different species and
agro-forestry products well adapted to the Alentejo region. The TCF have a
large capacity of internal interaction between different research groups in
creating cross chains of biomass recovery from the perspective of natural
bioactive extracts production.
These chains comprise three distinct areas: i) Reverse Genetics - selection
of plants that naturally produce large quantities of certain compounds; ii)
Functional Biology - assessing the potential of natural extracts in terms
of anti-oxidant, anti-inflammatory, anti-microbial and anti-tumour activity
and cytotoxic potential; and iii) Engineering Processes - extraction and
fractionation involving ultrafiltration, nanofiltration and reverse osmosis,
and a step of drying and formulation of the final product.
As a result of the regional context in which the CEBAl is inserted and as
a result of facilitated contacts with companies and producers, CEBAl has
focused on the study and valorisation of biomass from different species
and agro-forestry products well adapted to the Alentejo.
The last major up-grade of CEBAl was in methods: membrane systems
(reverse osmosis, micro and ultra-filtration). Regarding equipments CEBAl
has a Real Time PCR, Cryopreservation System, nanofiltration unit, HPlC
e GC and nanodrop.
ACCESS PolICy
The CEBAl has focused in proximity interactions with its associates, promoting
meetings and technical visits, which allows easier access to a wide network of
regional contacts, and to the most significant issues. Consequently, CEBAl is
already seen as a promoter and/or a partner of regional funding programs,
not only as the provider of R&D services, but mainly as a reference scientifictechnological partner.
Address
CENTRO DE BIOTECNOLOGIA AGRÍCOLA
E AGRO-ALIMENTAR
Rua Pedro Soares, Apartado 6158
7801-908 BEJA
PoRTUGAl
Contact detail
Jorge PUlIDo vAlEnTE
Tel. (+351) 284 311 800
jorge.valente@cebal.pt
www.cebal.pt
124
CITA
RESEARCH CENTRE OF FOOD
TECHNOLOGY
location
FARo, PoRTUGAl
Key words
oPTImIZATIon, DEvEloPmEnT oF
FooD PRoCESSES AnD PRoDUCTS,
ESTABlISHmEnT oF PRoDUCT SHElF lIFE.
CITA offers services to companies interested in commercializing new
products or improve production efficiency of existing ones, using the
facilities of the laboratories: Processing and new Product Development,
Rheology and Packaging, Functional Food / nutraceuticals, Food Security
and Enology in the following areas:
Development of products from pilot scale to industrial scale for
commercial application;
Determining the assessment of a product by consumers through
sensory analysis;
«Scale-up” of regional recipes for commercial application;
Development of packaging to maximize shelf life and aesthetics of
products;
Determination of time for food shelf.
The main competitive advantage is the existence of specialized human
resources in this areas and the existence of well equipped labs.
In the category of Biological Resources and Associated Infrastructures
CITA use the biological resources centres, banks, collections (for
collections of microorganisms.
In the category of Biotechnological Processes CITA uses fermentation
to produce food or drinks (traditional brew), fermentation for enzyme
production and fermentation for production of active compounds (for study
arbutus brandy, application of enzymes to break chemical bonds in the
production of juices).
In the category of Bioinformatics use data warehousing, construction
and management of databases, data analysis and biostatistics, modelling
systems (biotechnological processes, ecosystems, etc.) and computational
power (for analysis of experimental data).
The main equipment provided by the platform is:
Address
CITA
University of Algarve
Institute of Engineering, CITA
Campus da Penha
8005-139 FARo
PoRTUGAl
Contact detail
margarida vIEIRA
Tel. (+351) 289 800 535
mvieira@ualg.pt
Pilot scale equipment for processing and food processing
Chemical analysis (GC´s, HPlC’s)
Enology Equipment
microbiology and molecular Biology Equipment
The last major upgrade was the improvement of the Food Technology
laboratory, the creation of the laboratory of new products development
and sensory analysis.
ACCESS PolICy
The customer makes the contact and then the CITA provides the budget.
After this procedure is initiated the contracting (services are provided through
establishment of a protocol).
http://ise.ualg.pt
125
SANITARY
ENGINEERING
LABORATORY
location
FARo, PoRTUGAl
Key words
WATER AnAlySIS, PHyToREmEDIATIon,
APPlIED RESEARCH.
The Sanitary Engineering laboratory has the main aim to provide services
and applied research. Its main areas of expertise are the physico-chemical
and microbiological tests on all types of water and the soil, sediment, plant
material and residues, evaluation of the impact of forest fires in Riversides,
evaluation of metals and butiestanhos in sediments of saltmarshes and
Phytoremediation of pollutants in aquatic ecosystems.
The main competitive advantage is the accreditation of tests they carry
out and the capacity for innovator technology transfer, particularly at
the level of phytoremediation. In coming years the main objectives are to
contribute to compliance with the Water Framework Directive, provide a
platform of support services that serve the needs of regional companies
and its technological development.
This laboratory is associated in RElACRE - Association of Portuguese
Accredited laboratories which represents the Portuguese laboratories in
EURolAB.
The last major upgrade was in the microwave assisted digestion and
atomic absorption. In the category of Biological Resources and Associated
Infrastructures are used phytoremediation tests to remove pollutants in
aquatic ecosystems.
ACCESS PolICy
The services are provided to public and private clients. The visits to the laboratory
are conducted occasionally, as long as assembled the requirements of confidentiality. The users of equipment are the laboratory technicians, according to the
stipulations in the standard 17025.
Address
UNIVERSITY OF ALGARVE
laboratory of Sanitary Engineering
Campus da Penha
8005-139 FARo
PoRTUGAl
Contact detail
manuela moREIRA DA SIlvA
Tel. (+351) 289 800 175
msanti@ualg.pt or les@ualg.pt
http://ise.ualg.pt/index.php
126
nAvARRA,
SPAIn
FIDENA
(FOUNDATION FOR R&D IN
NANOTECHNOLOGY)
location
PAmPlonA, nAvARRA, SPAIn
Key words
nAnoTECHnoloGy, nAnoPARTIClES,
nAnoSTRUCTURES, BIomolECUlES,
AnTIBoDIES, BIo-FUnCTIonAlIZATIon,
BIoSEnSoR, THERAPy, DRUG DElIvERy.
Recent projects:
SABioD: Self assembled Bio-Active device: The main goal of the project is the
development of novel nanobiohybrid systems, mainly composed by biomolecules
and nanostructures (nanoparticles and nanopatterned surfaces) to create a
wide variety of products with novel properties, functions and applications in the
field of biotechnology, health and agrifood. At the moment the area specializes
on optical nanobio-sensors and functionalized nanoparticles as nanobio-probes
and nanobio-carriers.
Service, Technology and applications
Services
Physical and chemical characterization:
FE-SEm (Field emission scanning electron microscope): Size, morphology,
material composition…
Dynamic light scattering: Size, morphology, ζ-potential, polydispersity…
FTIR: Chemical composition.
Spectrophotometer Uv-vIS-nIR: Size, morphology…
Technology
nanoparticles: Synthesis of organic and inorganic nanoparticles in different
shapes, size and materials, tailoring their physical and chemical properties
towards bio-sensing and nano-carries applications.
Biofunctionalization: Surface chemical modification, including bioconjugation
with peptides, proteins, antibodies, nucleic acids and drugs. Functionalization
of inorganic and organic nanoparticles, nanopatterned surfaces and
biomedical implants with novel and specific functionality.
Biosensor: Development of lSPR (localized Surface Plasmon Resonance)
biosensors using nanoparticles or nanopatterned surfaces, applicable to
the determination of different compounds. The efforts are focused on the
development of fast, sensitive, low-cost and easy-to-use systems.
The main applications are related to BIoSEnSInG and THERAPy. I.e.:
Address
FIDENA
Centro de I+D “Jerónimo de Ayanz”
Campus de Arrosadía, C/Tajonar s/n
31006 PAmPlonA, nAvARRA
SPAIn
Detection of different analytes and biomarkers (proteins, cancer markers,
small molecules –histamine, lactose, antibiotics…- ).
nanobio-probes for signal amplification (enhanced ElISA, enhanced SPR).
nanobio-carriers for smart delivery of proteins, nucleic acids, drugs etc.
nanoparticles enabled hyperthermia to kill targeted cells or bacteria.
ACCESS PolICy
Reservations for the use of the equipment can be made sending an email or by
phone (at least a week before).
Contact detail
Ernesto BRAvo
Tel. +34 948 166 177
info@fidena.es
www.fidena.es
128
MUCOSAL DRUG/
ANTIGEN DELIVERY
UNIVERSITY OF NAVARRA
location
Key words
nAnomEDICInE, nAnoPARTIClES,
mICEllES, DRUG DElIvERy, AnTIGEn,
AllERGEn, vACCInE, TARGETInG,
ConTRollED RElEASE
In this proposal UnAv is represented by the research group “mucosal
Drug/Antigen Delivery”, ascribed to the Department of Pharmacy and
Pharmaceutical Technology of the School of Pharmacy. The group focuses
its research on (i) the delivery of drugs through biological barriers,
and (ii) the development of new mucosal adjuvants for vaccination
and immunotherapy. The group collaborates with public and private
academic and research institutions as well as technological centers and
pharmaceutical companies.
Concerning research facilities, the Department of Pharmacy and
Pharmaceutical Technology possesses apparatus for the formulation and
physico-chemical and biopharmaceutical characterization of dispersed
systems including colloids in general and, particularly, nanoparticles,
microparticles and lipid vehicles. In addition, these facilities include a
laboratory for the formulation of anticancer formulations and production of
adenoviral vectors for gene therapy. Similarly, the research group has also
facilities for cultured cells and animal studies (under GlP conditions).
Finally, it is also interesting to note the internal collaborations with
other groups of the University for the radiolabelling, biodistribution
(Radiopharmacy Unit) and toxicity studies (Toxicological Department).
Formulation of nano- and microparticles. nano- and microencapsulation
of drugs, antigens and allergens. Characterization of nano- and
microparticles, Bioavailability and pharmacokinetic studies
ACCESS PolICy
Access is studied case by case.
Address
DEP. FARMACIA
Y TECNOLOGÍA FARMACÉUTICA
University of navarra
C/Irunlarrea, 1
SPAIn
Contact detail
Juan m. IRACHE
jmirache@unav.es
Alex HAnSEn
Tel. +34 948 425 649
ahansen@unav.es
www.unav.es
129
DEVELOPMENT OF
FERMENTATION
STARTERS AND
PROBIOTICS
(CNTA)
location
SAn ADRIAn, nAvARRA, SPAIn
Key words
PRoBIoTICS, BIo-PRoCESSInG,
FERmEnTATIon STARTERS, mICRoEnCAPSUlATIon
DOMAIN OF EXPERTISE AND SERVICES OFFERED
Development of novel healthier or functional biobased foods/ingredients (fermentation and downstream processing), GRAS extraction
technologies (e.g. SFE).
micro/nanoencapsulation of bioactive compounds (BACs) or living
bacteria.
Bioprocesses: optimisation of fermentative processes, development
of starter cultures, biotechnological production of molecules of interest (e.g. BACs, biopolymers…).
new food processing technologies (HPP, PEF, RF…) as alternative
food preservation methods: improved nutritional and sensory foods.
modelling of product shelf life
Cell culture: testing of probiotics and bioactive compounds.
Tiny animal model (C. elegans): testing of probiotics and bioactive
compounds in vivo (Septembre 2012).
Fermentation technologies: selection and optimisation of starters
(e.g. for food production), development of bioprocesses for production of biobased food ingredients/additives and biopolymers/monomers (up to 60 liters).
microencapsulation of bioactive compounds and living bacteria
(food, nutraceutical, pharma, cosmetics): increased stability,
changes in physic-chemical properties, gastrointestinal resistance.
Address
CNTA
Ctra. nA-134 km 53
31570-SAn ADRIAn, nAvARRA
SPAIn
Contact detail
Carlos J. González nAvARRo
Tel. +34 948 670 159
cgnavarro@cnta.es
http://www.cnta.es
130
SECOND
GENERATION
BIOFUELS CENTRE
(CENER)
location
Key words
BIoFUElS, BIomASS, lIGnoCEllUloSES,
EnZymATIC HyDRolySIS, FERmEnTATIon,
BIoETHAnol
The general objective of the 2nd Generation Biofuel Centre of navarra is to
constitute a Process Development Unit (PDU) to produce 2nd generation
biofuels on a pilot scale level as an intermediate step towards the
industrial scale-up of these technologies and as a biorefinery test platform.
The PDU considers a complete range of alternatives, which permit the
integration of both conversion routes (thermochemical and biochemical)
and the development of biorefinery concepts aimed at an integral use of
the biomass and by-products generated in each one of the processes.
Expert knowledge includes:
Biomass (wood & herbaceous) handling and physical pretreatment
Advanced thermo-chemical pretreatment (Torrefaction)
vegetable cell wall deconstruction technologies
Enzymatic Hydrolysis
Aerobic & anaerobic fermentation
Product fractionation
Distinguishing feature:
Integral development of 2nd generation biofuels production
processes by both Thermo-chemical & Biochemical routes.
The possibility of processing all types of biomasses.
A wide range of 2nd generation biofuels of interest.
The constitution of a test platform for biorefinery processes.
Biomass and biofuels characterization
Bioenergy (2nd generation biofuels: cellulose based bio ethanol):
lignocellulosic biomass pre-treatments, enzymatic hydrolysis,
fermentation, separation & fractionation techniques… Able to
produce other oxygenated biofuels.
Fermentation for bio-based building blocks production (succinic acid,
lactic acid, butanol…)
other Bioenergy conversion routes: Biomass thermo-chemical
conversion processes
ACCESS PolICy
Address
CENER
C/ Ciudad de la Innovación, 7
31621 SARRIGUREn, nAvARRA
SPAIn)
The 2nd generation Biofuels Centre has a clear vocation to be open and at the
disposal of the scientific and enterprise community, proposing a high availability
for this access to both public and private organizations.
CEnER has a Business Development Department in charge of offering services
and installations to interested 3rd parties. In case of interest in any of the services
and/or techniques, each case would be analyzed and quoted separately.
Contact detail
Inés ECHEvERRIA
Tel. +34 948 252 800
iecheverria@cener.com
www.cener.com
131
ESTNA
ESCUELA SANITARIA TÉCNICO
PROFESIONAL DE NAVARRA
location
Key words
RADIoloGy, TECHnICIAn SCHool,
DIAGnoSTIC, mAmmoGRAPHy, DIGITAl
ImAGInG, TRAInInG, oRTHoPAnTomoGRAm
over 20 years of professional experience teaching Diagnostic Radiology.
ESTnA is a national Reference Centre for training technicians in different
heath technologies.
Training in diagnosis techniques and use of radiologic equipment
(mammography, digital imaging, radiology protection, nuclear
medicine, etc)
Collaborative experience with departments and services within
Government of navarra, professional associations, Spanish
ministries, autonomous organizations, trade unions, hospitals and
education centres.
The institution is a Public Technological Education Centre unique in Spain
due to its conventional radiography facilities, similar to any hospital
services, including real ionizing radiation use.
our equipment includes:
2 conventional diagnostic radiography equipments integrated in a
reception and processing DCR equipment
1 mammography unit
1 orthopantomogram unit
A laboratory equipped with a Conventional digitalized radiography
equipment,
A mammography unit and specific training in radiologic equipment
use with room for 8 students.
A laboratory equipped with a Conventional digitalized radiography
equipment, an orthopantomogram unit and specific training in
radiologic equipment use with room for 8 students.
ACCESS PolICy
Facilities and services are opened to training courses as well as diagnostic use
(excluding humans) for any interested entity.
Address
It will be mandatory for rental users groups and individuals to carry liability
insurance when renting a facility. It will be included in the billing price.
ESTNA
C/Irunlarrea 3
(Complejo Hospitalario de navarra–
Sector A : Hospital de navarra)
SPAIn
Applications should be sent to the centre´s administration.
Price of the service to be agreed individually
Contact detail
Conchita AnTon
Tel. : +34 948 198 698
escuela.sanitaria@educacion.navarra.es
http://centros.educacion.navarra.es
132
GERMPLASM BANK
SERVICE
(IDEN BIOTECHNOLOGY)
loCATIon
KEy WoRDS
GERmPlASm BAnK, TISSUE BAnK,
EXPlAnT, In vITRo CUlTURE, PlAnT
BIoTECHnoloGy, BIoCHEmICAl AnAlySIS
Iden runs a germplasm bank for the maintenance of vegetable material
stocks in the form of seeds and/or explants belonging to different species.
our infrastructures are available for the creation and maintenance of
third-partner´s collections that need to preserve the genetic diversity of
both commercial varieties and transgenic organisms of interest.
Iden has a strong know-how on plant and microbe molecular biology and
holds a well trained staff for an optimal service.
The germplasm bank equipment includes controlled environment
chambers for plant growth, ultra-low freezer and laminar flow cabinets,
among others.
The laboratory has typical molecular biology laboratory equipment.
other related services of the company are biochemical and enzymatic
analysis, metabolites analysis using chromatographic equipment and
fermentative analysis with plant material as substrate.
Germplasm bank
metabolic and enzymatic analysis of vegetable material and bacteria
molecular biology
Plant genetics
Recombinant protein production
Specific techniques: (PCR, northern and Western blots, vegetal cell
culture, vegetal and microorganisms transgenesis, plant models,
housing and facilities for plant experimentation, vegetal germplasm
bank, bioenergy processes)
ACCESS PolICy
To be defined for each type of service.
Address
GERMPLASM BANK SERVICE
Iden Biotechnology
Polig. mocholi, Plaza CEIn 1- of 8
31110 noAIn, nAvARRA
SPAIn
Contact detail
Xana BElASTEGUI
Tel. : +34 948 152 122
xana.belastequi@idenbiotechnology.com
www.idenbiotechnology.com
133
DAIRY INSTITUTE. ILL
location
lEKUmBERRI , nAvARRA, SPAIn
Key words
DAIRy, mIlK AnAlySIS, PCR, mIlK mICRoBIoloGy, QUAlITy ConTRol
Analysis of ex-farm milk and dairy products.
Services to the dairy sector.
The institute is specialized in milk and dairy products analysis including:
Quality and hygienic control of raw milk from dairy cattle, sheep and
goat in navarra and near provinces.
Analysis of dairy products and other food matrixes from industry,
Designation of origin Control Boards and Quality Certifying entities.
Control and calibration of equipment in production lines including
quality control samples and proficiency-testing programs
organization.
Regarding R&D, the Institute develops projects of general interest for the
sector, as well as specific projects in collaboration with private companies
aiming to improve techniques, industrial processes and product quality.
The organization collaborates with other technology centres, universities,
Designation of origin Control Boards and associated companies.
Technique improvement is a major issue in order to fulfill industry
demands.
Analytic techniques certified under ISo/IEC 17025 standard.
microbiologic analysis for product quality control: Salmonella, listeria
monocytogenes, Enterobacteriaceae, Staphyllococcus, mould and
yeast, Bacillus cereus, etc.
PCR technology for identification of mastitis pathogens and
microorganism; (mycoplasma agalactiae ovis, P. zopfii and P.
wickerhamii, BolA gene, etc (in development).
Residue and pollutant quantitative identification by HPlC/mS/mS.
Physico-chemical quality of milk (fat, protein, lactose content).
Quality management systems establishment and implementation
consultancy.
Address
DAIRY INSTITUTE. ILL
Plazaola, 23
31870 lEKUnBERRI, nAvARRA
SPAIn
Contact detail
nere BEREZIARTUA
Tel. : +34 948 507 215
imasd@illekunberri.com
Standard sample preparation for analysis, equipment verification
and control.
Disease testing.
IR Fatty acid profiling in milk (in development, innovative process
which main advantage is cost efficiency compared to traditional
chromatographic methods).
ACCESS PolICy
To be defined for each type of service.
134
www.illekunberri.com
PROTEOMICS,
GENOMICS AND
BIOINFORMATICS
(CIMA)
location
Key words
PRoTEomICS, GEnomICS, BIoInFoRmATICS
Disease mechanism definition and biomarker detection are the main activities of
the unit.
Proteomics:
Global proteome analysis is offered, based on the following specific services:
Consultancy on proteomics research
Protein identification (mAlDI-ToF or sequencing (ESI/mS/mS))
Post-translational modifications identification (ESI/mS/mS).
Small molecule analysis by mS.
Two-dimensional gels
Comparative proteome analysis by Differential in Gel Electrophoresis (DIGE).
Training practical courses recognized by the national Proteomics Institute
(ProteoRed), the Spanish Proteomics Society and the Spanish Biochemistry
Society
The laboratory takes part in the following projects:
Human Proteome organization:
Human Proteome Project. Chromosome 19.
national Proteomics Institute (ProteoRed)
Technological innovation, standardization and quality control in proteome
analysis.
Participation in contests promoted by the Association of Biomolecular Resource
Facilities (ABRF) consisting of resolving proteomic quests.
Genomics and Bioinformatics
Genome wide gene expression profiling.
Cytogenetic studies (CGH).
Genotyping.
Genotyping
Transcriptomics
DnA/RnA microarray (Affymetrix microarrays)
Differential proteomics
Peptide and protein identification and characterization (sequencing)
Bioinformatics: Data analysis and biostatistics, integration and interpretation, integrative biology
ACCESS PolICy
Address
CIMA
Avenida Pío XII, 55
SPAIn
An initial interview is mandatory to decide the best workflow fitting the
requirements of the project.
Service demands should be made through ProteoRed webpage (http://www.
proteored.org/), where prices are available.
External services to public national organizations represent 25% of the total
activities. The Unit is open to external collaborations.
Contact detail
Fernando CoRRAlES
Tel. : +34 948 194 700
fjcorrales@unav.es
http://www.cima.es
135
BIOFILTRATION FOR
ODOUR REMOVAL
(FIDIMA)
location
ESTEllA, nAvARRA, SPAIn
Key words
BIoFIlTRATIon, oDoUR REmovAl, H2S, nH3
Biofiltration is a versatile odour and gas treatment technology. They can
effectively remove odours and voCs from diluted air streams at relatively
low cost as compared with other alternatives.
In air treatment biofilters odours gases are forced through a filter bed
material that serves as support for microorganisms that metabolise the
compounds in the gas phase.
The main advantage of this biofilter against other biofiltration systems
is the high odour removal efficiency. The TCF has developed a substrate
which eliminates higher levels of H2S when compared with other organic
substrates, and at a low cost.
Another interesting characteristic is that the TCF includes a pilot modular
mobile biofilter, that can be located at any emission source to favor the
adaptation the microorganism to the specific pollutants. It can also be
used in industries that want to realize test in situ with a biofilter, before
the installation of the entire infrastructure, to study its efficiency and the
profitability of the inversion.
Additionally, this technology is environmentally friendly owing to the valorization of waste products.
Biofiltration for odour removal
Pilot modular mobile biofilter to make tests in situ in companies with
odour problems.
Sale of the organic substrate for biofiltration.
ACCESS PolICy
At the moment, the TCF is concluding the R&D phase and starting the patent but
the approximate prices are: Biofilter: 8000€ and Substrate: 44€/an.
Confidentiality contracts are signed by all the staff of the organization, company
and project partners and with other enterprises if it is required.
Address
FIDIMA
Centro Tecnologico miguel de Eguia
C/ Zaparuz, 1.
31200 ESTEllA, nAvARRA
SPAIn
Contact detail
Esteban mUEl
Tel. +34 948 111 201
e.muel@idima.es
www.idima.es
136
FLOW
CYTOMETRY UNIT
(NAVARRABIOMED)
location
Key words
FloW CyTomETRy, CEllUlAR SElECTIon,
CEllUlAR monIToRInG
Phenotypic and functional characterization of tumoral or immunological
subpopulations, especially in peripheral blood, bone marrow, lymphatic
node and apheresis products, are the most important issues for the
diagnostic and monitoring of immunodeficiencies and haematological
diseases.
The main advantage of the polycromatic flow cytometry is the
simultaneous analysis of multiple cellular antigenic markers. The
combination of cellular selection methods with the flow cytometry
optimizes the analysis of minor immunological subpopulations.
The Flow Cytometry Unit is equipped with a BD FACSCanto II Flow
Cytometer (Red, Blue and violet laser) that allows the analysis of 8 colors
or ten-parameters to elucidate complex antigenic expression or functional
activity (apoptosis, proliferation, cytokine production, cellular cycle, antigenspecific activation) of leukocyte populations or tumor-/virus-specific T-cell
subpopulations (Tetarmers, Pentamers and Streptamers).
Positive selection or depletion from biological samples by using ClinimACS
(miltenyi Biotec) -available from January 2013- and AutomACS (miltenyi
Biotec) automatic cell selectors can be performed of target cellular
subpopulations.
The facility also has tumoral monitoring capability, CellSearch System
equipment allows it. Epithelial and endothelial tumoral cells can be
quantificated and selected with this System for the later cellular or
molecular analysis.
ACCESS PolICy
Service demands or collaboration proposals should be made sending an e-mail to
nramireh@cfnavarra.es
Address
NAVARRABIOMED
Irunlarrea, 3
SPAIn
Contact detail
natalia RAmÍREZ
Tel. +34 848 422865
nramireh@cfnavarra.es
137
GENOMICS UNIT
(NAVARRABIOMED)
location
Key words
EPIGEnETICS, GEnomICS, BIoInFoRmATICS
our experience is based on the analysis of molecular alterations and gene
expression in cancer, related to survival and response to treatment, in
tumour samples and in vitro cell lines.
Genomics, Epigenetics and Bioinformatics
Pharmacogenetics
Epigenetic analysis
Sequencing and CGH-arrays: from January 2013
Pyrosequencing: from January 2013
methylation arrays : from January 2013
Data analysis and functional clustering: from January 2013
DnA modification and methylation-specific PCR
Individual gene and microRnA expression
Gene and microRnA expression using array-based technology: from
January 2013
DnA Sequencing by capillary electrophoresis: : from January 2013
CGH and Copy number variation studies: from January 2013
Immunofluorescence
ACCESS PolICy
dguerres@navarra.es
Address
NAVARRABIOMED
Irunlarrea, 3
SPAIn
Contact detail
David GUERRERo
Tel. +34 848 422 607
dguerres@navarra.es
138
PROTEOMICS UNIT
(NAVARRABIOMED)
location
Keywords
PRoTEomICS, BIoInFoRmATICS
Pathological and molecular mechanisms definition and biomarker
detection/identification in cancer and neurodegenerative diseases are the
main activities of the Unit
Proteomics:
The Unit offers global proteome analysis based on the following specific
services:
Consultancy on proteomic workflows
Experimental design
Different peptide fractionation methods
Protein identification by lC-mS/mS
Comparative proteome analysis by isobaric tagging of peptides or
label-free approaches (available during the first quarter of 2013).
The Proteomics Unit participates actively in Accredited Training Technical
Courses based on Clinical Proteomics recognized by the Spanish
laboratory Technicians Society (AETEl)
The proteomics lab takes part in the following projects:
Proteomic expression profiles of different breast cancer subtypes
molecular characterization of specific pharmacological resistance in
colon cancer
High-throughput proteomic/peptidomic analysis of specific human
brain subproteomes
Differential proteomics (available during the first quarter of 2013)
Protein/peptide characterization (sequencing)
Bioinformatics: Data analysis, integration and biological interpretation
ACCESS PolICy
Address
NAVARRABIOMED
Irunlarrea, 3
SPAIn
esantamma@navarra.es or jfernani@navarra.es
Contact detail
Enrique SAnTAmARÍA
esantamma@navarra.es
Joaquín FERnÁnDEZ-IRIGoyEn
Tel. +34 848 422 607
jfernani@navarra.es
139
BIOBANK
NAVARRABIOMED
location
Key words
HUmAn SAmPlES, BIomEDICAl RESEARCH
navarra Public Health Service Biobank is a service platform, with the aim
of improving the scientific knowledge in biomedical research providing
high quality human samples and their associated data to the scientific
community according to a precise ethical and legal setting that assures
the donor rights.
It is part of the Spanish national Biobank network, an initiative of the
Carlos III Health InstituteThe Biobank facilities are able to provide human samples for the study
of the prevention, diagnosis and treatment of a wide range of serious
and life-threatening illnesses – including, but not exclusive, cancer,
neurodegenerative diseases or genetic disorders.
Brain Bank: nervous system tissue and cerebrospinal fluid of various
neuropathological disorders and healthy donors.
Tumour Bank: Tumour and normal tissue, serum and DnA of various
kinds of malignancies and healthy donors.
other tissue and biological samples.
obtaining, handling, processing and storing human tissue and
biological samples for research. obtain, classify, preserve and
distribute human nervous system tissue.
Registration (including clinical data), preparation and preservation of
tissue and related samples.
Preservation of the anonymity and traceability of the samples.
Brain extraction and processing.
Processing for biochemical studies: frozen material.
neuropathological diagnoses.
management legal and ethical aspects.
Cession of samples for research.
Address
NAVARRABIOMED
Irunlarrea, 3
SPAIn
ACCESS PolICy
Any request of collaboration or material transfer agreement can be e-mailed to
isabel.gil.aldea@navarra.es or
For material transfer agreements, a material Request Application Form is
requested.
All interested should contact us and each request will be analyzed individually.
Contact detail
Isabel GIl-AlDEA
Tel. +34 848 422 607
isabel.gil.aldea@navarra.es
140
TOXICOLOGY UNIT.
CIFA.
UNIVERSITY OF NAVARRA
location
Key words
ToXIColoGy, In vIvo, In vITRo, CEll
CUlTURE, CyToToXICITy ASSAyS,
GEnoToXICITy, GlP CERTIFICATIon
The Toxicology Unit at CIFA offers diverse services related to preclinical
toxicity testing.
Studies can be carried out according to regulatory guidelines and Good
laboratory Practices (GlP). In addition to regulatory compliant versions,
versatile toxicity assays for basic research or for early stages of drug
development are offered.
The main domains of expertise of the Toxicology Unit are:
novel drug development (chemical and biotechnological drugs)
In vitro and in vivo toxicity of nanoparticles
Food toxicology (mycotoxins)
The Toxicology Unit also collaborates with the Instrumental Techniques
Unit which is certified for drug stability assays and the determination of
drugs in biological samples.
The Toxicology Unit is equipped with all the facilities needed for :
Biochemical and hematological analysis
Rodent/non- rodent studies
- Administration routes: oral, intravenous, subcutaneous,
intramuscular, dermal
- Study types: acute, repeated dose, maximum tolerated dose,
toxicokinetics, local tolerance, skin irritation/corrosion, ocular
irritation, germline studies
Cytotoxicity testing
- mTT reduction, neutral Red uptake, ATP content, lDH release,
cell proliferation, clonogenic assays, Propidium Iodide uptake, RoS
production (dichlorofluorescein assay)
Address
TOXICOLOGY UNIT
Centro de Investigación en Farmacobiología
Aplicada (C.I.F.A.)
Universidad de navarra
Irunlarrea, 1
SPAIn
Genotoxicity
- In vitro: Bacterial reverse mutation assay (Ames test), in vitro
micronucleus test, Comet assay, chromosome aberration test
- In vivo: micronucleus test, Comet assay
ACCESS PolICy
The demands can be submitted via e-mail. The experiments are conducted
according to the required specifications.
Customers/collaborations: industry and academia
Contact detail
Adela lóPEZ DE CERAIn
Tel. +34 948 425653
acerain@unav.es, cifa@unav.es
www.unav.es
141
NASERTIC
LABORATORY UNIT
location
vIllAvA, nAvARRA, SPAIn
Key words
DnA, GEnETIC, FEED, FooD, SoIl, WATER,
TRACEABIlITy, QUAlITy ConTRol,
RESIDUES
nASERTIC laboratory was established in 1994 and is dedicated to supply
environmental, agro food, toxicological and molecular biology analysis. We
are accredited by EnAC under ISo 17025 Standar for most of performed
analysis.
We are expert in analytical chemistry and molecular biology, offering
analysis on a variety of samples and analytes.
Entity designated by the navarra Regional Government to support
analytical navarra Regional Police and legal medicine Institute
We are licensed by the national Commission for the forensic use of DnA
analyzes for legal purposes.
Genetic analyzer (EC), PCR, RT-PCR. Sequencing, genotyping and STR
analysis in human and animal items:
Identification
Population studies
Traceability
Filiation
Genetic susceptibility
UPlC/mS, HPlC/mS, GC/mS, ICP/mS.veterinary Residues, pesticides,
metals, drugs and toxics in biological matrix.
Drugs of Abuse and alcohol in human blood, urine andoral fluid.
Identification of drugs in seized material.
Pesticides in food, water, soils, vegetals and feeds.
mycotoxins.
Antibiotics.
Hormones.
Tiriostatics.
Tranquilizers.
Toxics metals in food, feed, water and soil.
Elemental Analysis, ICP-oES, AAS, TGA, nIR. Physico-chemical and
microbiology analysis of food, feed, soil, water and plants. Elemental
Analysis, ICP-oES, AAS, TGA, nIR
nutricional analysis in food and feeds.
Soils properties studies.
Chemical composition of waters and microbiology.
Address
NASERTIC
Avenida Serapio Huici 20
31610 vIllAvA, nAvARRA
SPAIn
ElISA, Sero-neutralization, microscopy. Animal diseases.
TSE dissease control. BSE and Scrapie.
Equine viral arteritis.
Equine Rhinopneumonitis.
Equine Babesiosis.
Contact detail
Jesus lACAllE
Tel. +34 948007980
jlacallv@nasertic.es
ACCESS PolICy
Requests and consults should be submitted by email or phone. Each request will
be analyzed individually.
www.nasertic.es
142
PARTnERS
InDEX
ACKnoWlEDGEmEnTS
SHAREBIOTECH PARTNERS
SHAREBIOTECH PARTNERS
Bretagne Développement Innovation
(France) - Lead partner, administrative and financial
coordination, communication
Bretagne Développement Innovation is the regional, notfor-profit organisation for the promotion and support of
economic development and innovation for the Brittany region
in Western France.
Contact: Brian Monks – b.monks@bdi.fr
Jenny Giboire - j.giboire@bdi.fr
www.bdi.fr
Critt Santé Bretagne
(France) – Technical coordination
Critt Santé Bretagne is a not-for-profit organisation that
promotes co-operation between research units and
companies involved in R&D of health-related technologies in
Brittany. It is also involved in the coordination of Biogenouest,
the life science and environment technological core facility
network in Western France.
Contact: Céline Quéron – celine.queron@biogenouest.org
www.critt-sante.fr
Université de Nantes
cellule de valorisation de la recherche
(France)
The technology transfer department of Nantes University
aims at stimulating research valorisation actions within the
laboratories:
technology transfer, intellectual property, entrepreneurship/
start-up, research commercialisation capacity, technological
core facility valorisation etc.
Contact: Charlotte Lepère-Douard
charlotte.lepere-douard@univ-nantes.fr
www.univ-nantes.fr
Athlone Institute of Technology, Midlands
innovation and research centre, MIRC
Biocant
Associação de Transferência de Tecnologia
(Portugal)
Biocant is exclusively devoted to Biotechnology promoting the
creation of a cluster of companies and R&D institutions of
excellence in the centre region of Portugal.
Contact: Mariana Brandão - mbrandao@biocant.pt
www.biocant.pt
Centro de Ciências do Mar do Algarve, CCMAR
(Portugal)
CCMAR is an interdisciplinary centre for marine and
environmental science in Southern Portugal that is dedicated
to research and development, training and dissemination.
Contact: Deborah Power - dpower@ualg.pt
www.ccmar.ualg.pt
Centro Interdisciplinar de Investigação
Marinha e Ambiental, CIIMAR
(Portugal)
CIIMAR is a research centre focused on marine and
environmental sciences in Northern Portugal. CIIMAR is
dedicated to research and to the dissemination and transfer
of technology in the area of marine and environmental
sciences.
Contact: Agostinho Antunes - aantunes@ciimar.up.pt
www.ciimar.up.pt
Universidade do Algarve
Divisão de Empreendedorismo e
Transferência de Tecnologia, CRIA
(Portugal)
CRIA is the University of Algarve interface organism, aiming at
increasing the technology and knowledge transfer generated
in the university.
Contact: Ana Isabel Gonçalves - aigoncalves@ualg.pt
www.ualg.pt
(Ireland)
Athlone Institute of Technology is a higher education and
research centre that encompasses MIRC, a converging hub
for innovation,
research and enterprise in the Midlands, as well as various
technological core facilities in human health and environment
domains.
Contact: Paul Tomkins - ptomkins@ait.ie
Michael Lonergan – mlonergan@ait.ie
www.ait.ie
National University of Ireland, Galway
(Ireland)
NUI Galway is a research-led University with internationally
recognised expertise in translational stem cell and gene
therapy research, and home to a marine biodiscovery
research programme. NUI Galway is currently Ireland’s top
university in the creation of spin out companies, licenses and
patents.
Contact: Ilaria Nardello - inardello@marine.ie
www.nuigalway.ie
Gobierno de Navarra, Departamento de Innovación, Empresa y Empleo
(Spain)
The Department of Innovation, Enterprise and Employment
of Navarra government aims at stimulating technological
innovation within its local enterprises, through the continuous
definition and implementation of pro-active regional innovation
policies.
Contact: Begoña Sesma - sesmavea@navarra.es
Maria José Fernandez - mjfernandez@cein.es
www.navarra.es
Index
A
agriculture 7
agrifood 7, 111, 128
agronomy 23
algebra systems 73
alzheimer 39, 89
animal breeding 7
animal health 7, 14, 57, 123
animal models 13
antibiotics 142
antibody 46, 50, 88, 128
aquaculture 41, 120
aqueous 31
Atlantic Area 3
autism 67
chromatography 115, 121
chromosomes 19
clean room 100
clinical research 21
computer 27, 73, 88, 113, 117
cosmetics 7, 32, 43, 44, 48
cosmetics cryomicroscopy 20
cryopreservation 124
cyclotron 9
B
bioanalysis 91
biodiversity 109
bioenergies 116, 120, 131
biofiltration 136
biofuels 131
bioinformatics 27, 54, 86, 104, 122,
D
databases 27
diabete 39, 83, 88, 100
digestive function 13
disinfectant 49
distillation 31
DnA 12, 46, 49, 64, 68, 103, 108, 109,
G
gene
12, 28, 29, 42, 46, 49, 62,
64, 86, 90, 95, 105, 108
genome
12, 26, 27, 36, 64, 66,
94, 95, 109, 122, 135, 138
genotyping 67, 108, 135
glycoanalysis 96
glycoscience 96
GmP 29
H
healthcare 16, 48, 121
HIv 65
human health 7, 14, 57, 128
121, 135, 140, 142
drug
28, 37, 40, 46, 47, 59, 63, 72, 74,
83, 99, 106, 128, 129
125, 135, 138, 139
biomarkers 25, 110
biomass 116
biomedical 23, 123
biomolecular11, 111, 89
biopharmaceutical 42
biopolymers 10
bioprocess 24, 130
bioresources 24
biostatistics 38, 104
biotechnology 3, 45, 48, 49, 52, 88,
95, 101, 124
biotherapeutics breeding
28, 33,
40, 49
breeding
123
C
cancer 13, 16, 39, 65, 70, 83, 88, 98
cardiovascular 13, 83
cell 18, 26, 29, 30, 37, 42, 46, 49,
50, 70, 71, 75, 80, 84, 85, 88, 91, 94,
107,112,, 130, 137
characterization
44
E
ecotoxicology 30
electroencephalography 58
electrophoresis 52
electrophysiology 13
electroretinography 74
embryology 30
energy 7
environment 7, 16, 24, 115, 121, 122
environment enzyme 72
epigenetics 138
epigenomics 66
ethanol 43
F
finger nucleases 26
flow cytometry 70, 71, 74, 94
fluorescence 18, 19, 22, 55, 71, 74, 75,
80, 110, 112, 113, 138
I
imaging
18, 20, 21, 22, 23, 25,
28, 35, 75, 77, 82, 92, 112, 132
immunocytochemistry 18
immunophenotyping 26
industry 7
in vitro 20, 35, 39, 47 133, 141
in vivo 28, 35, 39, 74, 90, 141
isotope 34
L
laser 15, 55, 60,
lipidomics 14
82
M
marine (biotechnology,
products) 35, 41, 45, 48, 95, mass
spectrometry 10, 25, 61, 106, 121
mathematics 73
metabolomics 14, 57
microalgae/ algae 33, 41
microbiota 36
microdissection 18
microscopy 10, 18, 20, 60, 74, 75,
78, 79, 84, 94, 98, 112
microscopy milk microbiology
134
mitosis 19
molecular 17, 19, 23, 26, 34
47, 49, 64, 69, 72, 79, 88, 97, 105, 108,
117, 120, 128, 133, 139, 142
morphology 18
multiphoton microscopy
multiphysics 73
mutagenesis 53
20
O
obesity 39
oncology 9, 38, 72, 92
ophthalmology 114
optics 55
P
peptide 25, 34, 59, 128, 135, 139
pharmabiotic 94
pharmaceutical 16, 30, 39, 40, 43, 44,
skin 37
software development 114, 116
solvent-free 31
spectrometry 22, 52, 54, 98
spectrophotometry 121
spectroscopy 22, 23, 55
stevia 32
subcloning 53
supercomputing 98
synthesis 44
122, 129
pharmacology 87
pharmacotoxicology 15
phenotype (ing) 10, 30, 101
physicochemical 28
physics 87
phytoremediation 126
plant (health, product) 7, 14, 49, 124,
133
polymer 91, 99
polyphenols 31
polysaccharides 10
probiotic 36, 130
protein 17, 25, 26, 33, 40, 42, 46, 50,
T
tale nucleases 26
telepathology 83
therapy/therapeutics 9, 42, 100
tissue 18, 37, 65, 71, 99, 107, 112,
140
tissue bank 133
tissues tomography 20, 23
toxicity 80, 107, 123, 141
toxicology 16, 37, 39, 54, 91, 122,
traceability 142
transgenesis 30
two photon 76, 84
54, 56, 90, 105, 106, 133, 135
proteomics
N
nanoelectronics 93
nanoencapsulation 130
nanomedicine 40
nanoparticle 63
nanoSImS 22
nanostructure 85
nanotechnology 93, 128
neurodegenerative 39, 140
neurogenesis 76
neuroinformatics 21
neurology 58
neuropathological 140
neuroscience 21, 56, 98, 113
nuclear 9, 46
nucleic acid 97
nutraceuticals 31, 32
nutrition 7, 16, 36
25, 52, 66, 88, 106, 135,
139
purification
U
umbilical cord
43
R
radioactive assays 90
radiochemistr 9
radioisotope, 9
radiology 132
rat transgenesis 26
regenerative medicine
S
scanner 23
screening 72, 80, 98
sequencing 12
107
V
vaccine 46, 50, 129
vegetable 31, 49
veterinary 40
virtual slides 15
virus 29
vitamins 32
98
crédit photo : BDI-Emmanuel Pain
ACKnoWlEDGEmEnTS
Jenny Giboire, Caroline Jousset and Brian monks
(Bretagne Développement Innovation, France),
Céline Quéron and Jocelyne le Seyec
(CRITT Santé Bretagne, France),
Christelle Hays
(Biogenouest, France)
Charlotte lepère-Douard
(University of nantes, France),
Begoña Sesma vea
(Gobierno de navarra, Spain) and
maría José Fernández
(CEIn, Spain),
Ana Frade and mariana Brandão
(Biocant, Portugal),
Deborah Power and margarida Rossi
(CCmAR Centre of marine Science, Portugal),
Ana Isabel Gonçalves
(University of the Algarve, Portugal),
Agostinho Antunes
(CIImAR Interdisciplinary Centre of marine and Environmental Research, Portugal),
Ilaria nardello and Rebecca Corless
(national University of Ireland, Galway, Ireland),
vincent Walsh and Paul Tomkins
(Athlone Institute of Technology, Ireland)
Sharing life science infrastructures and skills
to benefit the Atlantic Area biotechnology sector
Creation
Design
Agence Conseil en Communication
www.comunik.fr
Investing in our commun future

lIFE SCIEnCE TECHnoloGICAl CoRE FACIlITIES

Transcription

Similar documents

Make MS matter in Election 2016

Travel Brochure - Post Insurance

I have lived one of the best years of my life

Tony Kenny - CMI Entertainment

A stroll through historic Kilmainham

Over 50s Funeral Plan

Foinse project - Quakers and Business Group

EC-YP one page flyer

Nursing and Residential Staffing Solutions

Inlandsbanan A3.indd