here - Campus Biotech

November 4th, 2014
Contact: benoit.dubuis@fcbg.ch
04/11/2014
FCBG
Dr. B. Dubuis
1
Swiss Center for Affective
Sciences
Campus Biotech
Université de Genève
CENTRE INTERFACULTAIRE
EN SCIENCES AFFECTIVES
Who
 The Swiss Center for Affective Sciences hosts
one of Switzerland’s 27 National Centers of
Competence in Research (NCCRs)
 First interdisciplinary research center
dedicated to the study of emotions and their
effects on individual behavior and society
 Host institution: UNIGE
 Launched September 1st, 2005
 14 research teams (120 collaborators)
 6 Universities
SWISS CENTER FOR
AFFECTIVE SCIENCES
Mission
3 overarching research topics
 How are emotions elicited and expressed?
 How are emotions regulated?
 How do emotions modulate life in society?
3 objectives
 Scientific research
 Application of research findings in public and private sectors
 Training a new generation of interdisciplinary researchers
SWISS CENTER FOR
AFFECTIVE SCIENCES
Why at Campus Biotech
Research
 Integrate new approaches and domains in order to conduct
interdisciplinary research on emotion, and on its links with,
for instance, health and well-being
 Collaborating on new projects using state-of-the-art
facilities
Links with society
 Connect with other partners in the Campus Biotech in order
to interact with society at large with respect to applied
research and knowledge transfer
SWISS CENTER FOR
AFFECTIVE SCIENCES
Forecast
Development of the CISA
 The Centre Interfacultaire en Sciences Affectives (CISA) will
be particularly developed in the coming years; being part of
the Campus Biotech will bring new possibilities
Development of new areas of application
 We will develop links with several domains of society (e.g.,
health, work, family, peace building and conflict resolution,
energy efficiency, law, finance, and the arts)
SWISS CENTER FOR
AFFECTIVE SCIENCES
Neurosciences humaines et neuroimagerie
Neurosciences humaines et neuroimagerie
• Département de Neurosciences Fondamentales (CMU)
• Département de Neurosciences Cliniques (HUG)
• 5 groupes:
–
–
–
–
–
Anne-Lise Giraud
Narly Golestani
Christoph Michel
Sophie Schwartz
Patrik Vuilleumier
• Chaque groupe 10-25 collaborateurs (doctorants, postdocs)
Neurosciences
Faculté de Médecine
Circuits cérébraux normaux et pathologiques
fonctions
anomalies
anatomie
Développements et
applications de méthodes de
neuroimagerie de pointe
pour explorer :
IRM structurelle
IRM par diffusion
Neurosciences
Faculté de Médecine
rééducation
IRM fonctionnelle
EEG
MEG
Circuits cérébraux normaux et pathologiques
Neuroimagerie multi-modale des processus sensorimoteurs, cognitifs,
et émotionnels:
 comprendre, mesurer, prédire, et traiter
 fondamental, clinique, et applications translationnelles
IRM structurelle
IRM par diffusion
Neurosciences
Faculté de Médecine
IRM fonctionnelle
EEG
MEG
Neurologie du Comportement et Imagerie Cognitive
Prof. Patrik Vuilleumier
Mécanismes cérébraux des
fonctions cognitives,
connections, et réseaux
Impact fonctionnel de lésions
(e.g. accident vasculaire, SEP)
Régulation émotionnelle et
dysrégulation en psychiatrie
(e.g. dépression, anxiété)
Imagerie en temps réel
de l’activité et/ou connectivité
de régions cérébrales et
modulation par neurofeedback
Laboratoire de Cartographie Cérébrale
Prof. Christoph Michel

Développement de méthodes d’analyses de l’EEG de haute résolution

Combinaison de l’imagerie électrique avec l’imagerie hémodynamique.

Etudes des processus sensoriels et cognitifs chez l’homme.

Développement de méthodes non-invasives permettant de localiser des
foyers épileptiques.

Etudes des perturbations et récupérations fonctionnelles après des
lésions cérébrales.

Etudes sur des bio-marqueurs précoce en EEG des patients à risque
de troubles psychiatriques (schizophrénie, autisme, bipolaires).

Combinaisons avec la stimulation magnétique transcrânienne (TMS)

Etude des modèles animaux des réseaux cérébraux fonctionnelles
avec de l’EEG multicanaux chez des souris et rats.
Laboratoire Langage & Cerveau
Prof. Narly Golestani
Recherche sur le langage et le cerveau:
•
•
•
Mécanismes de production et perception de la parole, l’apprentissage du langage, le
bilinguisme, l’expertise, et la plasticité cérébrale
Différents niveaux de fonctionnement: processus auditifs, linguistiques, ainsi que des
fonctions qui vont au-delà du langage (ex. fonctions exécutives)
Différentes méthodes d’imagerie, principalement l’imagerie par résonance magnétique
fonctionnelle (IRMf) et structurelle (VBM, DTI)
Laboratoire Audition & Langage
Prof. Anne-Lise GIRAUD
implant cochléaire
surdité
enregistrement
des neurones
activité
du cerveau
(IRM, EEG, MEG)
anomalies
du cortex
dyslexie
bégaiement
communication parlée
et ses pathologies
autisme
modélisation
Neuroimagerie du sommeil et de la cognition
Prof. Sophie Schwartz
Apprentissage
Sommeil, émotions, et
troubles de l’humeur
Réactivation en sommeil
Média et sommeil chez les
adolescents
Décoder les rêves
Pourquoi rêve-t-on?
 Mécanismes et régulation de la plasticité cérébrale et des apprentissages
Synergies sur le Campus Biotech
• Comprendre l’architecture cérébrale, de la perception et du
mouvement à la cognition et aux émotions; comprendre leurs
dysfonctions lors de maladies neurologiques et psychiatriques
 CISA et HUG
• Mesurer et décoder les signaux neuronaux et le fonctionnement
des réseaux cérébraux
 interfaces cerveau-machine, neuro-prothèses: CNP EPFL
• Développer et valider de nouvelles méthodes d’enregistrement et
de modulation/stimulation de l’activité cérébrale
 implants et électrodes, hardware et software: Institut Wyss
• Modélisation et simulation de réseaux cérébraux
 Human Brain Project
• Ouvertures vers la gestion de “big data” et applications en politique
de la santé
 Institut de Santé Globale (UNIGE et HUG)
Human neuroscience and neuroimaging
cluster
Merci pour votre attention!
Neurosciences
Faculté de Médecine
•
Questions?
The Economist, 2010
Healthomics
Campus Biotech, Genève
Des données intelligentes pour une
meilleure santé
• Maîtriser le déluge des données qui inonde le domaine
de la recherche biomédicale, des soins et de la santé
• Innover en synergie dans la «Health Valley» lémanique
• Impliquer sérieusement les citoyens
• Implémenter des solutions concrètes et en démontrer
l’impact réel
Pourquoi Campus Biotech
• Au centre de gravité de l’Arc Lémanique
• A proximité de l’EPFL et des organisations
internationales et ONGs
• Des collaborations avec l’Institut de Santé Globale,
l’Institut Suisse de Bioinformatique
• De nouvelles dynamiques: science citoyenne, sciences
affectives…
HI5Lab
Health Informatics for
Innovation, Integration,
Implementation and Impact
Prof. Antoine Geissbühler
Kids-e-transplant
Healthy Together
RAFT
Human Brain Project
unifying our understanding of the human brain
Prof. Dr. Felix Schürmann
Ecole Polytechnique Fédérale de Lausanne
The Human Brain Project
A European Flagship Project with 112
international partners coordinated by
EPFL
Mission
Future Applications
Neuroscience
Medicine
Computing
• Build an integrated ICT
infrastructure enabling a
– global collaborative effort
– towards understanding the
human brain,
– its diseases, and ultimately
– to emulate its computational
capabilities
Integration
ICT Platforms
Data,
Knowledge,
Technologies…
fragmented
Campus Biotech and Geneva
a perfect environment for the Human Brain Project
• Home for Human Brain Project headquarters
• Home for EPFL scientists, engineers and students
involved in the Human Brain Project
• Co-location with other scientific endeavors at the
Campus Biotech such as Wyss Institute, Center for
Neuroprosthetics, UNIGE, etc.
• Central location in Europe
• Proximity with other stakeholders in world health such
as WHO, UN and others
Outlook
• Remote Collaboration: Modern communication and
visualization facilities boost our abilities to co-ordinate and
collaborate locally and remotely
• A vibrant hub for team work: The layout of the B1 building
boots our ability to host external collaborators and teams for
short and extended periods of time
• Home for future growth: The size of the B1 building has
capacity to absorb our future growth with additional
scientists and research topics aligned with the HBP
• Outreach: Progressively, outreach capabilities will be
added to HBP’s presence in the Campus Biotech for an
interested public to see first hand the accomplishments of
the project
Thank You!
The Human Brain Project Consortium
http://www.humanbrainproject.eu
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Dr. B. Dubuis
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Wyss Center
11/10/2014
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The Wyss Center is a unique research
organization funded by a donation of
CHF 100 million from the entrepreneur
Hansjoerg Wyss. The Center, which will
be one of several groups located within
the campus, aims to accelerate science
and engineering research by providing
the skills and resources needed to create
innovative neurotechnology for human
benefit.
Dr. B. Dubuis
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Wyss Center
Board of the
Foundation
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Dr. B. Dubuis
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Wyss Center
Management
PROF. JOHN DONOGHUE
PH.D
Director
Dr. Benoît Dubuis
PH.D
Director of Development
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Wyss Center as an Accelerator: from idea to product
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Wyss Center
platforms
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Find the slides on:
www.campusbiotech.ch
Dr. Benoit Dubuis
benoit.dubuis@fcbg.ch
11/10/2014
FCBG
Dr. B. Dubuis
39
EPFL Center for Neuroprosthetics
Neuroprosthetics
Discover the brain’s engineering,
computational, and neuroscience
principles for sensorimotor and
cognitive processing.
Exploit these insights to create
neurotechnological materials and
devices to revolutionize healthcare in
neurological and psychiatric disease
and the design of new technologies.
EPFL Center for Neuroprosthetics
Brain Mind Institute, Institute of Bioengineering,
Institute of Microengineering
School of Life Sciences, School of Engineering
Medical Image
Processing
Laboratory
Defitech Foundation
Chair in vision
restoration
Dimitri Van de Ville
Diego Ghezzi
7 research groups
120 full-time researchers/technical staff/PhD students
EPFL Center for Neuroprosthetics
EPFL Center for Neuroprosthetics
Our medical network in Western Switzerland
EPFL Center for Neuroprosthetics
Four dreams …
-
Walk Again (Spinal Cord Injury)
Rehabilitation of motor and cognitive deficits (Stroke)
Artificial Arm (Amputation)
Cogniceuticals (Chronic Pain & Neuropsychiatric disease)
EPFL Center for Neuroprosthetics
Walk Again
(Spinal Cord Injury)
Courtine group
Motor rehabilitation stroke
Robotics
Millan group
Brain-Computer
Interface
Real-time
Brain Imaging
Stroke
EPFL Center for Neuroprosthetics
Lacour group
Electronic Skin & Soft Neural Interfaces
• Circuitry designed to undergo large deformations
• Embedded information processing
• Relay to the nervous system
Electronic Skins
Neural interfaces
stretchable
conductors
touch sensors
elastic thin-film
transistors
APL 2003, 2009
Transducers’11
APL 2011
soft neural regenerative
nerve
electrodes
implants
JNE 2012
2011
EPFL Center for Neuroprosthetics
Artificial Arm & Skin (Amputation)
Neuroengineering to control movement and touch (pain) of the robot arm
Micera group
Neural implant
Bionic Arm
Towards electroceutical treatments in amputation, stroke,
spinal cord injury …
EPFL Center for Neuroprosthetics
Virtual & Augmented Reality
Neuroscience &
Cognition
Cogniceuticals
Mobile, wearable, and
integrated
neuroprosthetic
technologies for
neuropsychiatric disease
Robotics, Smart Textiles & artificial skin
Artificial skin
Pharmaco-electrical neuroprosthesis
Brain Imaging
Vestibular prosthesis and processing
Electromyography
Soft flexible electrodes
Modeling
Brain-computer interface Physiology
Cochlear implants and brainstem implants
Decoding
Pharmacology
Spinal cord repair
Brain stimulation
Spinal
Epilepsy Amputation Stretchable conductors
Haptics
Sensorimotor processing
Virtual reality
Touch
Locomotion
Cortico-cortical neuroprosthesis Cognition
Magnetic resonance imaging
Exoskeleton-wearable robotics
tDCS
Stroke
Cord Injury
Regenerative nerve implants
Thank you!
Signal analysis
Neurorobotics
Institut de Santé Globale
strategie et développement
http://goo.gl/gkSmZ6
Ecole Romande de Santé
Publique
Santé Globale
Recherche/Formation
(« Implementation science»)
Institut de Santé Globale
• Trois divisions
– Cancer et Prévention (C Bouchardy, JF
Etter, B Borisch)
– Santé Mentale Publique et Vieillissement
(E Albanese et A Stuckelberger)
– Droits Humains (E Kabengele)
• Unité Relations Internationales
– B Stoll, B Borisch
• Lab. Big Data en Santé (A Flahault)
• 35 collaborateurs (dont 10 RGT), 6
professeurs
• PhD in Global Health (EN)
• Master of Global Health (EN)
• Formation Continue
– MAS santé publique ; CAS promotion de
la santé ; CAS santé mentale publique
Master of Global Health
of the University of Geneva (2015)
Ecole Romande de Santé
Publique
PhD in Global Health
http://goo.gl/gkSmZ6
MOOC “Ebola : vaincre ensemble !”
• 60 vidéos
• 30 intervenants
• Co-production franco-suisse
MOOC “global health: an
interdisciplinary overview”
“I am very interested if
UNIGE is planning to
prepare a Master´s course
in Global health. I am
finishing my Bc. studies in
summer and would like to
continue with Master in
Global health or some other
similar program in distant or
specific form of studying. If
UNIGE will provide this kind
of program I would like to
apply for it.”
• 45 videos
– (34 UNIGE + 11 external)
Week 1:
Week 2:
Week 3:
Week 4:
Week 5:
Week 6:
Week 7:
Week 8:
Introduction to Global Health concepts
Emerging trends in global health: Infectious diseases
Emerging trends in global health: Non-communicable diseases and disability
Governance for global health, health systems and financing
Foreign policy, trade and health
Research, development, innovation and technology for global health
The environment, sustainable development and health
Overview and Assessment
GHF 2016
L’innovation pour l’hôpital périphérique (de district)
Ecole Romande
de Santé Publique
Assemblée Mondiale de la Santé
« policy & technical briefs »
• Délégations techniques de 194 pays
– Agenda chargé, technicité, manque d’expertise
– Besoin d’une expertise académique indépendante et neutre en deux
axes : policy brief et technical brief
• Partenariat UNIGE-IHEID
– En collaboration avec WFAIGH, OFSP, OMS
4 November 2014
SIB Swiss Institute of Bioinformatics 2014
• 52 groups
• 650 scientists
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SIB missions
To provide worldclass core bioinformatics
resources to the life
science research
community
• To provide core databases,
software and services
• To provide key competencies and
research support
To lead and
coordinate the field
of bioinformatics in
Switzerland
• To federate Swiss bioinformatics
researchers
• To train first-rate researchers
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SIB at Campus Biotech
Personalized health, transforming medicine
The patient,
coming to the
consultation
«Big Data»
generated by
modern
technologies
e.g. genetic
sequencing
Data management
Analysis and
interpretation
Integration of
information from
specialized
databases
Consolidated report
to support diagnosis
and treatment
decisions
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SIB at Campus Biotech
Swiss-Prot
Manually annotated, cross-referenced,
documented protein sequence knowledge
resource >542,000 proteins
Vital-IT
Bioinformatics competence center supporting and
collaborating with life scientists
Multi-disciplinary team providing expertise and
training, and maintaining a high-performance
computing (HPC) and storage infrastructure, so as
to help develop, maintain and extend life science
and medical research.
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Forecast
Cost of sequencing vs. bioinformatics
Sboner et al. Genome Biology 2011, 12:125
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Thank you
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Development of Bio-electronic Interfaces for
chronic monitoring of 3D tissues derived from
human Stem Cells
Luc Stoppini – Neurobiologist
Prof. of Bio-Engineering
hepia, University of Applied Sciences
Geneva
Research Projects
« Mini-Brains » in a Dish: In vitro monitoring of 2D
and 3D human neural networks to study neuroregenerative processes as well as for
neurotoxicology testing
2D and 3D neural cultures derived from human Stem
cells (ESCs and iPS cells)
Technologies
• Fast prototyping:
Manufacturing of BioChips
• Electrophysiology Systems:
Muti-Electrode Arrays
• 3D Printers
• 3D Bio-Printers
Why are we coming to the Campus Biotech?
• Development of a Tissue Engineering Platform
• Collaboration with the different groups working
on “Brain Interface Computer and Technologies”
• In vitro validation of new developed neuroprobes
before their in vivo implantation
• Participation to the development of the Medical
device Research group of the CB
Forecast
• Development of a new generation of hybrid
neuroprobes that will combine electrode arrays
with human encapsulated neural networks
derived from the patient before their
implantation.
• The connections with the host brain will be
realized through the biological encapsulated
neural networks grown onto the electrode arrays.
Acknowledgments/collaborations
Other faculty members involved from
hepia:
Laboratory of
Tissue Engineering
Prof. Luc stoppini
Igor Charvet
Laetitia Nikles
Antonin Sandoz
Alessandra Gastaldello
Adrien Roux
Sébastien Rosset
Romain Germanier
François Duval
Gregory Fischler
Mathurin Baquié
Prof.Philippe Passeraub: Design and
miniaturization of new sensors and
transducers
Prof. Valérie Duay  computing,
image and signal processing
Prof. Stéphane Bourquin  applied
photonics, optoelectronics, bioinstrumentation, optical coherence
tomography
Dpt of Pathology
and Immunology
Prof. Karl-Heinz Krause
Michel Dubois-Dauphin
Olivier Preynat-Seauve
Stéphanie Julien
Prof. C. De Geyter
A.C. Feutz
Prof. Dr. Martin Wilks (Director)
Florianne Tschudi-Monnet
Jenny Sandstrom
Marie-Grabrielle Zurich
Funding:
Prof.Denis Hoschstrasser
Nicolas Toni
Find the slides on:
www.fcbg.ch
Dr. Benoit Dubuis
Benoit.dubuis@fcbg.ch
04/11/2014
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Project History and Milestones
• Concept
Dec. 2000
• Final Building Permit
Dec. 2002
• Land Required
March 2003
• Demolition of Existing Site
May 2003
• Detailed Design
2003-2004
• Start with General Contractor
April 2004
• Admin Move Start
Nov. 2006
• Labs Move Start
Jan. 2007
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Key Partners
Architects: Murphy/Jahn, Mackay
Partners, Oxalis
Engineers and consultants: Werner
Sobek (WSI), L-Plan, Lerch Bates,
AAB,
General Contractor: Karl Steiner
S.A.
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Current Situation
Key features:
40’000 m2
Gross Area
Facades/Atrium/Forum/Open Roof 24’383 m2
4’270 m2
Landscaping
+ 200 trees
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Building Presentation
• The phase 1A includes the buildings B1, B2
and B3 (new buildings) and H4, H8 and G6
(old buildings).
H ALL 46 0 S EATS
• Buildings B1, B2, H4, G6 & H8 are all
destined to an administrative type work
environment. These buildings consist of
offices, meeting points and conference
rooms (exception is the ground floor of G6
where the day care is located).
H8
PARKI NG
68 SPACES
G6
K ITC HEN
B3
FORUM
H4
B2
S HOP /
TRAVEL
A GENCY
G IA 1137.3 m ² - NIA 863.6 m²
B1
• Building B3 is the laboratory building, and it
houses all the laboratories with associated
offices and support functions.
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Key Features
Gross Area
Workspaces
# of parking
# of meeting rooms
Cafeteria Restaurant
Facades/Atrium/Forum/Open Roof
Auditorium
Security
Day-care
Fitness
Data Centre
Landscaping
Lake Water Concept
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Dr. B. Dubuis
40’000 m2
1’300
330
55
460 seats
24’383 m2
300 Seats
148 CCTV
520 m2, 52 places
550 m2
600 m2
4’270 m2 + 200 trees
Sustainable Development
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