phamaceutical and analytical evaluation of talsindura rasa

Transcription

ISBN 978-93-5173-179-3
ISSN 2320-7329
http://www.ayurlog.com
Vol. 3
Issue- 1st Jan- Mar 2015
Ayurlog: National Journal of Research in Ayurved Science
A Web based quarterly online published Open Access peer reviewed National E-journal of Ayurved
PHAMACEUTICAL AND ANALYTICAL EVALUATION OF
TALSINDURA RASA
___________________________________________________________________________
Pendse vandana khushalrao*1
___________________________________________________________________________
1. Professor ,post graduate department of Rasashastra and B.K.
Ashvin rural A yurved college. Manchi -Hills ; Sangamner , Tal. Sangamaner Dist.
Ahemadnagar.(M.S.)
* Corresponding Author: Email:Pendse_vandana@rediffmail.com. Mobile No. 9096487911
___________________________________________________________________________
mentioned varies parameters to evaluate
the kupipkwa rasayana..some
ABSTRACT:
modern
analytical tools can also adopted to asses
Rasashastra is a science of minerals and
these method. Here an attempt is made to
these mineral products are toxic in nature1.
evaluate and prepare talsindura – rasa by
These are
traditional method and do analytical study
subjected to process to
shodhana, marana, jarana, murchchna,
of obtained sample.
kajjali, kupipakwa rasayana to convert into
KEYWORDS:
nontoxic and absorbable. In Rasashastra
Kupipkwa , murchchna , shodhana ,jarana
various methods are available to convert
, kajjali. Marana.
mercury in the form of which is beneficial
INTRODUCTION:
to our body for
curing the diseases in
Ayurveda has interacted with various
certain dose . Talsindura-rasa is Herbo-
medical systems from time to time and this
1
mineral preparation, It is important to
interactions2 along with updated research
mention that sindura group of kalpas are
has facilitated its growth . The importance
named on the basis of their red colour like
of
that of sindura. Prepared by Kupipkwa
emphasizing towards chikitsa in which all
method.
unique,
principles is laid down in acute condition
efficacious, potent, difficult and gandhak
for better and quicker results.1 These
jarana plays an important role in it. The
preparations are suppose to be harmful to
ancient scholars of Rasashastra have
our body as per western medicine, but in
This
method
is
1
herbo-mineral-metal
preparations
ISBN 978-93-5173-179-3
ISSN 2320-7329
Vol. 3
Rasashastra text the adverse effects are
also ensure safety limits and accuracy of
mentioned
has
drug7. In the present era in order to
played a major role in popularizing
establish the safety concern the prepared
Ayurveda
drug should be understood well
already.
in
Rasa-shastra
masses.
Ayurvedic
and
physicians are of the view that various
interpreted with the help of modern
pharmaceutical processes in ayurveda like
technology and must be supported by
shodhana
proper
(purification),
scientific
validation.8
Physio-
marana(inceineration), murchchna, jarana,
chemically talsindura-rasa is HgS and
kupipkwarasayana etc. converts metallic
AS2O3 but after doing XRD test(X-Ray
preparations into non-toxic. In current
diffraction). Iron (Fe2O3) found in the
kinetic era rasaushadhies have given
upper part of medicine in trace amount8.
Ayurveda a complete novel health care
Aims and Objectives:

look1.
Talasindura-rasa
is
a
haerbominaral
which is made in

valukayantra. In
haritala
Shuddha
and
Pharmaceutical
study
of
bhaishajya manimala.

gandhaka,shuddha
shuddha
by
talsindura rasa according to siddha
talsindura-rasa kajjali prepared of shuddha
parada,
prepare Talsindura-rasa
kupipkwa rasayana vidhi.
preparation prepared by kupipkwa method
3
To
To Evaluate the ancient
gouripashana.
modern
Gandhak jarana plays an important role in
studies.
parameter in
and
analytical
enhancing the potency of mercury and
MATERIAL AND METHODS :
arsenic. This jarana process claimed many
Materials :
pharmacological and therapeutic properties
in mercury. So dhatu
rasayana
has
its
Rasabhaga rasata :.
yukta kupipkwaimportance
punraikaikstalmallagandhakta:
in
Kupyam
Rasashastra.
paripchetpwankaffuw hanti talsindura
A standard operative procedure in the
: // - r.yog .s . & s.b.m.m.
preparation of talsindura-rasa, along with
Shuddha parada(H g),
certain analytical methods helps to reveal
out
the
chemical
composition
dwayham
Shuddha gandhaka (S)
of
Shuddha haritala ( AS2 S3),
formulation with there concentration and
2
ISBN 978-93-5173-179-3
ISSN 2320-7329
Vol. 3
Shuddha gauripashana (AS2 O3)
etc .―shodhana is done as per reference
.
text.1
Method:
Selection and collection of raw material
Preparation of Talsindura rasa
drugs as per grahya lakshnas
as per
2 1
Ref : siddha bhaishajya manimala
reference text.
Materials :
Parada shodhana was carried out by doing
shuddha parada – 600 gm
trituration in khalwa yantra. with( lime,
shuddha gandhaka – 100 gm
rason kalka ,saindhav lavana ).
Shuddha haritala -100 gm
days.then it is washed to get back 9.
shuddha gauripashana-100 gm
Gandhaka shodhana was done in
Methods ; kupipkwa rasayana
gogruita and dissolved gandhak liquid is
Equipments:
poured into godugha.we get solid slab of
Valuka yantra, prepared kanchkupi, cork,
sulphur. Then washed with hot water.
shalakas, copper coins, torch, bhatti ,
Dried and powered.procedure is repeated 3
thermometer etc.
times13.
Procedure :
Haritala shodhana was carried out by
The whole procedure was divided into 3
doing swedana with the help of dola yantra
phases15.
in
I) purva karma
kushmand
For
7
heating
swarasa.(benincasa
hispida)14
ii) pradhan karma
iii) paschat karma .
Gauripashana
Purva karma:
karavellak
Collection
(momordica charantia) by doing swedana
of necessary equipments :
shodhana
swarasa
is
done
with
bitter
guard
Mortar and pestle, Kanchkupi – (A Glass
with the helpof dolayantra.14
of bottle which is wrapped with rag and
Preparation of Kajjli.
mud of 7 layers and dried .) the thickness
were weighted accurately.
of rag and mud sealing is quoted to be of
Mixed
0.75 inch.
and trituration was started till the kajjali
Valuka
vessel filled with
yantra ( earthen
sand
upto 8‖ –9 thickness.
at the bottom
become
Shuddha dravyas
together in stony khalwa yantra
black
,
slakshnatwa
,and
Bhatti ( for fire
completely nishchandra . bhasma pariksha
) Thermometer ( to moniter the amount
done .the kajjali powder is then filled into
of heat )―― Cork,
a bottle(1/3 part) which is covered seven
Iron shalakas ,torch
3
ISBN 978-93-5173-179-3
ISSN 2320-7329
Vol. 3
times with
kapda mitti.after drying,the
black in colour. kanthastha and Talashta
kachkupi bottle is kept in valuka yantra
talsindur rasa shiny blakish red parpati
and sand is filledupto the neck of bottle.
rupa and was collected and weighted ..
Pradhan karma :
RESULTS :
In the pradhan karma gradual heating
Analytical evaluation ;
schedule is kramgni
This evaluation devided into two parts.
for 24 hours/ temp
recorded.10
1 . Ancient method
Mrudu agni : Room temp to 2000C (8
2 . Moder n method .
0
hrs)
Madhyam agni; 200-400
C (8
hrs)
Teevragni ; 450 -650 0C(8 hrs) is
Ancient Method :
A) Analytical
parameters for physical
1
given in valuka yantra . shalaka sanchalana
characters ;
–(the mouth of bottle is kept open with
1 . Varna (colour) - - Redish black shiny.
heilp of a red hot iron strirer) and
2. Nishchandratwa – (lusterless ) – present
observation of fumes and flames. Copper
3. varitaratwa - (flotness) - present
coin test done . appearencre of redness at
4.Unam test – properly present (excellent)
the bottom. Adherence
of mercury
5.Rekhapurnatwa
particles . then closing of the bottle mouth
present(genuine )
should be done when extra sulphur is burn
6.Slakshanatwam—present.
completely. The fumes stop coming out of
7 .sukshmatwa (fineness) – Present.
the mouth of the bottle . the joints of the
8.anjana
cork and the mouth should be seald
present.9.physical state- churna powder
properly with molasses and lime powder
form.
made into paste with water , after this
B.) Analytical parameters for chemical
Teevr agni applied .
characters ;8
Pashchat karma :
changes as compound formation. Etc. the
The swangasheeta bottle(after cooling on
below mentioned parameters are to be
its own)
considered.
was broken
tactfully
and
(furrow filling ness)-
sannibha
(softness)-
To assess the chemical
sublimate deposited Talsindur rasa at the
1. Gatarasatwa (Tasteless) –present
neck
2.
and
(kanthstha /
bottom of kanch kupi.
talastha) .talsindura rasa
Apunarbhavatwa
(irreversibility)
present
3 .Nirutthatwa – present.
.while taking out,it looks redish yellow
4
-
ISBN 978-93-5173-179-3
ISSN 2320-7329
Vol. 3
( specially done for haratala mixed
at different stages of kupipkwq rasayanas
bhasma – no melting or fumes).
process..
Modern Methods:
Analysis of Talsindura –rasa
1.) XRD – X –ray diffraction studies 8
The
.X –ray diffraction methods are based on
Organoleptic and physico- chemical are
the scattering of x –rays by crystals. It is
suggestive of sample is
helpful to check product
sparsha , redish black crystals in rupa, .
Qualitatively.
data
(Table-1)
pertaining
to
corrosive on
And Identify a given sample. Evaluate
the sample of parada
different compounds with same chemical
churna was analysed for the total mercury
formula but different structure
and it was found 78 .90%. the sample of
.
For
determine the arrangements of atoms in
residue
minerals and metals. Talsindura rasa
mercury. The result of analysis
sample on 100-800 at the scattering rate
negative .It indicates there is absence of
40/mm of 6kw energy.xrd pattern is
parada in residue sample obtained from
mercuric sulphide
and AS2o3 . And fe2o3
kupi . so it may be inferred that mercury
is in trace . this elements is either by raw
totally was converted in arsenic form and
material ,mortar
sublimated completely .along with trace
or the plant extracts
added during trituration.8
2)Atomic
Absorption
was analyzed for estimation of
was
elements .
Speetro
scopy
Black red shiny in varna ,Ash value can
(AAS)3 It can identify the trace elements
be calculated
present in
kupipkwa rasayana bhasmas
mercury ,14.31% ofsulphur and 13.28 %
qualitatively .it is the best Analytical
of haritala ,3.28% of gauripashana(malla), 1
method to evaluate
Talsindur - rasa is shown to contain
the presence of
Arsenic and Iron3.
3)
Differentiol
in sample78.90% of
mercuric sulphide (Hg S)associated with
Thermal
AS2S3 several organic micro molecules
Analysis
(DTA)6
derived from
It provides information on the chemical
during
reaction , phase transformation ; structural
Fe2O3 is found in this sample is in trace
changes etc, occurs in a sample during
amount.
heat up and cool down cycle. Helpful in
DISCUSSION:
the probable chemical reaction that occurs
5
the
the plant
extract
processing. Of
used
the drug.
ISBN 978-93-5173-179-3
ISSN 2320-7329
Vol. 3
Kupipkwa method is very unique, and is
For
best
tituration do not use metal khalwa
example of murchchna. Talsindur
murchchna of kajjali
mixture
use
rasa is prepared by kupipkwa rasayana
stone or porcelain khalwa to prevent the
method satisfied the required criteria of
loss of kalpa.
traditional
analytical
techniques
.Talsindur rasa should be considered as
REFERENCES:
Mercuric
1) Rasashastra , dr, Damodar Joshi ..
sulphide as major constituent
along with arsenic and
iron as trace
edited
by
dr,shreekumari
Amma.,
elements The results conformed the
Publication Division Ayurveda College
presence of heavy metals as Fe , Ar and,
Trivendrum, 1985 pages 320 -321.
S , and Hg .in the prescribed
2)Rasayogasagar
pharmo
,
pt,
Hariprapannaji
copeial limits. Shodhana is necessary for
Sharma ,vol -1 talsindura rasa yog 154 /
materials .because of proven
695. Published by krishnadas academy
effects and
into
converts these
toxicity
Varanasi 2nd edition 1982 , page 585.
preparation
non –toxic and digestible and
absorbable.
In classical
kupipkwa method
importance for
.3)
literature
,Bhatt R, kaladhar.
has given more
gandhak
. Siddha bhaishajya manimala ,shri
published
pancham guchch /37
by choukhamba
crishnadas
academy ,Varanasi 3rdedition 2003 ,page
jarana, it
depends upon the quality of gandhaka and
364,
types of agni i.e. kramagni .in valuka
4) . Parameters on quality assessment of
yantra on
ayurveda & siddha drugs –part
bhatti.(specialized
heating
pattern –indirect constant heat )
CCRAS , New delhi .
During
5 )Parada Vigyaniyam ,
preparation of nirgandha kajjali
A .
vasudev m.d.
there was a loss of 5%.it may be due to
Sharma Ayurveda Mandir ,Datia 1997 -
process or human error. During talsidura
277.
rasa preparation
6)Instrumental
350 gm of kanthastha
methods of chemical
st
part was obtained out of 900 gm of kajjali
analysis , DR.B .K. Sharma 21
. and talastha part was obtained 500 gm
,Goel publishing house 2002 p- 352 -357.
of kajjali. Weight of parada is not
7)Shri Gopalcrishna Bhatt. Rasendra sar
increased .
sangraha , motilal Banarasdas prakashan
6
edition
ISBN 978-93-5173-179-3
ISSN 2320-7329
Vol. 3
4th edition ,Varanasi . rasayana chapter
12) Ayurved
65 -70 . p 627 -629.
rasayana
8)Anonyms
for
pharmacopoeial
Ayurvedic
council for
standards
research
in ayurveda and
Ayurved Bhavan ,limited
216.
13) Bhartiya
9)Bhashajya ratnavali, pandit lalchand raji
Vaidya
vaidya 1924
,1928,
Hindi ,publishers motilal
Rasashastra
Yadavji
Aushadh Gunadharma
Trikamaji
edition 1924 , Sanskrit
part -4 ,Vd.Panchanan Gune
Aacharya
Vaidya Yadavaji
Trikamji Acharya . Mumbai ,India. 2 -21 -
Gangadharshastri , published by vaidyak
24.
grantha bhandar ,pune edition 1998 page
15) Rasartnasamuchchaya,
91.
Dudhgaonkar ,Kulkarni .1
11)Rasa Tarangini
Marathi
14 ) Ayurved Prakash -Shrimadhav 1st
banarsidas , delhi ,India.
Shastra
kupipkwa
Nagpur, edition Sept 2009 , page 211 -
siddha , new delhi 1987
10)Ayurvediya
,
prakashana , published by shri
Baidyanath
formulations , central
sarsangraha
Pt, Kashinathshastri,
shashtha tarang , published by
.Marathi ,
Motilal
Vagbhata ,
st
edtion 1972
Shivaji UNIVERSITY ,
Kolhapur .India. 3 -70 , 125
th
Banarasidas , Delhi ,4 edition 1979
reprint 1994 ,page 140 -146 .
Table -1 : Observation and Results of Analytical Tests
Sr.
Parameters
Kajjali
No.
Talsindura-rasa
(in percentage)
1
Loss of Ignition
2
Loss of drying at 110 0c
3
Ash value
4
Acid insoluble ash
5
Water soluble ash
6
( in percentage)
0.72
0.45
2.12
2.12
2.50
5.25
0.05
0.27
0.30
0.25
Mercury as Hg
53.65
78.90
7
Sulphur as S
38.70
14.31
8
Harital as AS2S3
24.11
13.28
9
Gauripashana as AS2O3
18.02
3.28
w/w
w/w
w/w
w/w
7
ISBN 978-93-5173-179-3
ISSN 2320-7329
Vol. 3
10
Iron as Fe2O3
-------
Table- 2 Observation and Results of Analytical
Sr.
parameters
1
Varna ( colour)
Tests
0.72
( Ancient method )
Talsindura rasa
Redish black shiny
2
Nishchandratwa(lusterless)
present
3
Varitaratva (flotness)
present
4
Unam test
Properly present (excellent)
5
Rekhapurnatva(furrow filling ness)
Present (genuine)
6
Slakshanatwam
present
7
Sukshmatwa (fineness)
present
8
Anjana Sannibha (softness)
present
6
4
Series 1
2
Series 2
0
A
B
C
D
E
100
80
60
40
20
0
Series 1
Series 2
A
B
C
D
E
Bar Diagram 1 Analytical Evaluation of Kajjali and Talsindura-rasa
Bar Diagram 2 Analytical evaluation of Kajjali and
Talsindura-rasa
A – Loss of ignition B- loss on drying at 110 0C C – Total ash value
A – Mercury as Hg B – Sulphur as S C- Harital AS2S3
D- Gauripashan
D- Acid insoluble ash E – water soluble ash %
as AS 2O3 E – Iron as Fe2O3 %
8
ISBN 978-93-5173-179-3
ISSN 2320-7329
Vol. 3
Cite this article:
PHAMACEUTICAL AND ANALYTICAL EVALUATION OF
TALSINDURA RASA
Pendse vandana khushalrao
Ayurlog: National Journal of Research in Ayurved Science-2014; 3(1): 1-9
9

phamaceutical and analytical evaluation of talsindura rasa

Transcription

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